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Invitrogen
TCF7L1 Polyclonal Antibody
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FIGURE: 1 / 2
TCF7L1 Antibody (PA5-106757) in ICC/IF
Immunocytochemistry analysis of TCF7L1 in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with TCF7L1 polyclonal antibody (Product # PA5-106757) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Product Details
PA5-106757
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TCF7L1(Accession Q9HCS4), corresponding to amino acid residues P321-K371.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total TCF7L1.
Target Information
This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HMG box transcription factor 3; T-cell factor 3; TCF-3; transcription factor 3; Transcription factor 7-like 1; transcription factor 7-like 1 (T-cell specific, HMG box); transcription factor 7-like 1 (T-cell specific, HMG-box); transcription factor 7-like 2 (T-cell specific, HMG box)
Gene Aliases: bHLHb21; TCF-3; TCF3; TCF7L1
UniProt ID: (Human) Q9HCS4, (Mouse) Q9Z1J1
Entrez Gene ID: (Human) 83439, (Rat) 312451, (Mouse) 21415
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific double-stranded DNA binding
molecular_function
chromatin binding
beta-catenin binding
sequence-specific DNA binding
transcription regulatory region DNA binding
DNA-binding transcription factor
chromatin organization
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
Wnt signaling pathway
regulation of Wnt signaling pathway
canonical Wnt signaling pathway
biological_process
anterior/posterior axis specification, embryo
somatic stem cell population maintenance
skin development
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter during mitosis
axial mesoderm morphogenesis
stem cell differentiation
regulation of stem cell population maintenance
transcription, DNA-templated
generation of neurons
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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