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TCF7L1/TCF7L2 Monoclonal Antibody (2B2D12), CoraLite® Plus 488

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TCF7L1/TCF7L2 Monoclonal Antibody (2B2D12), CoraLite® Plus 488

Product Details

CL488-67652

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

0.4 µg/1x10^6 cell suspension
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

2B2D12

Immunogen

Recombinant protein
3D Epitope / Immunogen

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Purification

Protein A

Storage buffer

PBS with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: MPQLGGGGGG GGGSGGGGGS SAGAAGGGDD LGANDELIPF QDEGGEEQEP SSDSASAQRD LDEVKSSLVN ESENQSSSSD SEAERRPQPV RDTFQKPRDY FAEVRRPQDS AFFKGPPYPG YPFLMIPDLS SPYLSNGPLS PGGARTYLQM KWPLLDVPSS ATVKDTRSPS PAHLSNKVPV VQHPHHMHPL TPLITYSNDH

Target Information

TCF7L1 is one of TCF/LEF transcription factors that are mediators of the Wnt signaling pathway and are antagonized by the TGF-beta signaling pathway. It binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. It's necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. This antibody raised against 1-200aa of human TCF7L1 can also react with TCF7L2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: contains exons 1, 2, 3, 4, 5, 6, 7L, 8, 9L, 10, 11, 12, 13, 17; contains exons 1, 2, 3, 4, 5, 6, 7L, 8, 9L, 10, 11, 12, 15, 17; contains exons 1, 2, 3, 4, 5, 6, 7L, 8, 9L, 10, 11, 12, 17; contains exons 1, 2, 3, 4, 5, 6, 7L, 8, 9S, 10, 11, 12, 13, 14, 17; contains exons 1, 2, 3, 4, 5, 6, 7L, 8, 9S, 10, 11, 12, 13, 17; contains exons 1, 2, 3, 4, 5, 6, 7L, 8, 9S, 10, 11, 12, 17; contains exons 1, 2, 3, 4, 5, 6, 7S, 8, 9S, 10, 11, 12, 17; contains exons 1, 2, 3, 5, 6, 7L, 8, 9L, 10, 11, 12, 15, 17; contains exons 1, 2, 3, 5, 6, 7L, 8, 9L, 10, 11, 12, 17; contains exons 1, 2, 3, 5, 6, 7L, 8, 9S, 10, 11, 12, 13, 14, 17; contains exons 1, 2, 3, 5, 6, 7L, 8, 9S, 10, 11, 12, 15, 17; contains exons 1, 2, 3, 5, 6, 7L, 8, 9S, 10, 11, 12, 17; contains exons 1, 2, 3, 5, 6, 7S, 8, 9S, 10, 11, 12, 17; contains exons 8, 9L, 10, 11, 12, 13, 14, 17; HMG box transcription factor 3; HMG box transcription factor 4; hTCF-4; mTCF-4; T-cell factor 3; T-cell factor 4; T-cell-specific transcription factor 4; TCF-3; TCF7L1/2; TCF7L2; transcription factor; transcription factor 3; Transcription factor 7-like 1; transcription factor 7-like 1 (T-cell specific, HMG box); transcription factor 7-like 1 (T-cell specific, HMG-box); Transcription factor 7-like 2; transcription factor 7-like 2 (T-cell specific, HMG box); transcription factor 7-like 2 (T-cell specific, HMG-box); transcription factor 7-like 2, T-cell specific, HMG-box; unnamed protein product

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Gene Aliases: bHLHb21; mTcf-4B; mTcf-4E; TCF-3; TCF-4; TCF3; TCF4; TCF4B; TCF4E; TCF7L1; TCF7L2

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UniProt ID: (Human) Q9HCS4, (Human) Q9NQB0, (Mouse) Q9Z1J1, (Mouse) Q924A0

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Entrez Gene ID: (Human) 83439, (Human) 6934, (Mouse) 21415, (Mouse) 21416

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding sequence-specific double-stranded DNA binding transcription regulatory region sequence-specific DNA binding transcription corepressor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding beta-catenin binding ligand-dependent nuclear receptor binding protein kinase binding sequence-specific DNA binding gamma-catenin binding RNA polymerase II sequence-specific DNA binding transcription factor binding armadillo repeat domain binding promoter-specific chromatin binding chromatin binding transcription regulatory region DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II repressing transcription factor binding transcription factor binding nuclear hormone receptor binding DNA-binding transcription factor
Process(es)
chromatin organization regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter Wnt signaling pathway regulation of Wnt signaling pathway canonical Wnt signaling pathway negative regulation of transcription from RNA polymerase II promoter blood vessel development response to glucose positive regulation of epithelial to mesenchymal transition positive regulation of heparan sulfate proteoglycan biosynthetic process pancreas development positive regulation of insulin secretion regulation of hormone metabolic process glucose homeostasis maintenance of DNA repeat elements fat cell differentiation negative regulation of gluconeogenesis negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter myoblast fate commitment regulation of smooth muscle cell proliferation positive regulation of epithelial cell proliferation positive regulation of protein kinase B signaling negative regulation of androgen receptor signaling pathway negative regulation of canonical Wnt signaling pathway positive regulation of protein localization to nucleus negative regulation of type B pancreatic cell apoptotic process negative regulation of extrinsic apoptotic signaling pathway transcription, DNA-templated anterior/posterior axis specification, embryo somatic stem cell population maintenance skin development positive regulation of transcription from RNA polymerase II promoter during mitosis axial mesoderm morphogenesis generation of neurons stem cell differentiation regulation of stem cell population maintenance cellular glucose homeostasis glycogen metabolic process glucose metabolic process transcription from RNA polymerase II promoter cell cycle arrest cell proliferation cellular response to starvation post-embryonic development positive regulation of triglyceride biosynthetic process oligodendrocyte development neural tube development pituitary gland development bone mineralization negative regulation of BMP signaling pathway embryonic genitalia morphogenesis regulation of myelination positive regulation of protein binding secretory granule localization multicellular organism growth catenin import into nucleus regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter negative regulation of fibroblast growth factor receptor signaling pathway odontogenesis of dentin-containing tooth positive regulation of apoptotic process negative regulation of sequence-specific DNA binding transcription factor activity canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition negative regulation of fat cell differentiation positive regulation of gluconeogenesis positive regulation of transcription, DNA-templated negative regulation of organ growth positive regulation of protein export from nucleus positive regulation of lipid biosynthetic process embryonic digestive tract morphogenesis embryonic hindgut morphogenesis regulation of skeletal muscle tissue development regulation of oligodendrocyte differentiation face morphogenesis regulation of insulin secretion involved in cellular response to glucose stimulus insulin metabolic process
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