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Proteintech
TCIRG1 Polyclonal Antibody
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Product Details
12649-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TCIRG1 Fusion Protein Ag3378 (25-395 aa encoded by BC018133)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Amount
28.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: CVSRLGELG LVEFRDLNAS VSAFQRRFVV DVRRCEELEK TFTFLQEEVR RAGLVLPPPK GRLPAPPPRD LLRIQEETER LAQELRDVRG NQQALRAQLH QLQLHAAVLR QGHEPQLAAA HTDGASERTP LLQAPGGPHQ DLRVNFVAGA VEPHKAPALE RLLWRACRGF LIASFRELEQ PLEHPVTGEP ATWMTFLISY WGEQIGQKIR KITDCFHCHV FPFLQQEEAR LGALQQLQQQ SQELQEVLGE TERFLSQVLG RVLQLLPPGQ VQVHKMKAVY LALNQCSVST THKCLIAEAW CSVRDLPALQ EALRDSSMEE GVSAVAHRIP CRDMPPTLIR TNRFTASFQG IVDAYGVGRY QEVNPAPYTI IT (25-395 aa encoded by BC018133)
Target Information
The T-cell immune regulator 1 (TCIRG1) is the a3 subunit of the vacuolar-type proton transporting ATPase (V-ATPase), a proton pump in late endosomes and lysosomes that functions in the luminal acidification of these organelles. Genetic defects in the gene encoding this protein a responsible for a severe form of autosomal recessive osteopetrosis, a condition that leads to increased bone density, decreased bone strength, and inflammation in bone tissues. TCIRG1 is also required for the normal secretion of insulin and the bacteria-killing function of macrophages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATPase, H+ transporting, 116kD; OC-116 kDa; Osteoclastic proton pump 116 kDa subunit; specific 116-kDa vacuolar proton pump subunit; T-cell immune regulator 1; T-cell immune response cDNA 7; T-cell immune response cDNA7 protein; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3; TIRC7; transmembrane protein; V-ATPase 116 kDa subunit a 3; V-ATPase 116 kDa subunit a3; V-ATPase 116-kDa; V-ATPase subunit a3; V-type proton ATPase 116 kDa subunit a; V-type proton ATPase 116 kDa subunit a 3; V-type proton ATPase 116 kDa subunit a3; vacuolar proton translocating ATPase 116 kDa subunit A; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3
Gene Aliases: a3; Atp6i; ATP6N1C; ATP6V0A3; OC-116kDa; OC116; OPTB1; Stv1; TCIRG1; TIRC7; Vph1
UniProt ID: (Human) Q13488
Entrez Gene ID: (Human) 10312
autophagosome assembly
ossification
osteoclast proliferation
ion transport
cellular calcium ion homeostasis
autophagy
apoptotic process
inflammatory response
cellular defense response
vacuolar acidification
protein catabolic process in the vacuole
lysosomal lumen acidification
positive regulation of cell proliferation
regulation of proton transport
response to silver ion
gene expression
regulation of gene expression
immunoglobulin mediated immune response
macroautophagy
optic nerve development
establishment of cell polarity
myeloid cell differentiation
B cell differentiation
T cell differentiation
osteoclast differentiation
ruffle organization
protein localization to organelle
memory T cell activation
T-helper 1 cell activation
odontogenesis
T cell homeostasis
tooth eruption
bone resorption
regulation of osteoblast differentiation
pH reduction
homeostasis of number of cells
regulation of insulin secretion
intracellular pH reduction
establishment of vesicle localization
retina development in camera-type eye
hematopoietic stem cell homeostasis
enamel mineralization
cellular response to cytokine stimulus
phagosome acidification
dentin mineralization
hydrogen ion transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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