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Invitrogen
TCIRG1 Polyclonal Antibody
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Product Details
PA5-90425
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
2.22 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MGSMFRSEEV ALVQLFLPTA AAYTCVSRLG ELGLVEFRDL NASVSAFQRR FVVDVRRCEE LEKTFTFLQE EVRRAGLVLP PPKGRLPAPP PRDLLRIQEE TERLAQELRD VRGNQQALRA QLHQLQLHAA; Positive Samples: U2OS, A-549, BxPC-3, U-937, HL-60, Mouse thymus, Mouse skeletal muscle, Rat thymus, Rat skeletal muscle; Cellular Location: Membrane, Multi-pass membrane protein
Target Information
The T-cell immune regulator 1 (TCIRG1) is the a3 subunit of the vacuolar-type proton transporting ATPase (V-ATPase), a proton pump in late endosomes and lysosomes that functions in the luminal acidification of these organelles. Genetic defects in the gene encoding this protein a responsible for a severe form of autosomal recessive osteopetrosis, a condition that leads to increased bone density, decreased bone strength, and inflammation in bone tissues. TCIRG1 is also required for the normal secretion of insulin and the bacteria-killing function of macrophages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATPase, H+ transporting, 116kD; ATPase, H+ transporting, lysosomal I; ATPase, H+ transporting, lysosomal V0 protein a; OC-116 kDa; osteoclastic proton pump; Osteoclastic proton pump 116 kDa subunit; osteosclerotic; specific 116-kDa vacuolar proton pump subunit; T cell immune response cDNA7 protein; T-cell immune regulator 1; T-cell immune response cDNA 7; T-cell immune response cDNA7 protein; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3; TIRC7; V-ATPase 116 kDa subunit a 3; V-ATPase 116-kDa; V-ATPase a3; v-H+ATPase subunit a3; V-type proton ATPase 116 kDa subunit a; V-type proton ATPase 116 kDa subunit a 3; V-type proton ATPase 116 kDa subunit a isoform 3; vacuolar proton translocating ATPase 116 kDa subunit A; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3
Gene Aliases: a3; ATP6a3; Atp6i; ATP6N1C; ATP6V0A3; oc; OC-116; OC-116kDa; OC116; OPTB1; Stv1; TCIRG1; TIRC7; Vph1
UniProt ID: (Human) Q13488
Entrez Gene ID: (Human) 10312, (Rat) 293650, (Mouse) 27060
cellular defense response
vacuolar acidification
protein catabolic process in the vacuole
positive regulation of cell proliferation
insulin receptor signaling pathway
ATP synthesis coupled proton transport
ATP hydrolysis coupled proton transport
proton transport
macroautophagy
transferrin transport
ion transmembrane transport
vacuolar proton-transporting V-type ATPase complex assembly
phagosome acidification
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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