Transcobalamin I (TCI) and Transcobalamin II (TCII) are secreted proteins belonging to the eukaryotic cobalamin transport proteins family and also to the vitamin B12-binding protein family. The genes encoding these proteins map to chromosome 11q11-q12 and 22q12.2, respectively. Transcobalamin I is a constituent of secondary granules in neutrophils, while Transcobalamin II binds cobalamin and mediates its transport into cells. These plasma proteins are expressed in various tissues and secretions.
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Protein Aliases: haptocorin; Haptocorrin; HC; Protein R; TC I; TC-1; Transcobalamin I; transcobalamin I (vitamin B12 binding protein, R binder family); Transcobalamin-1
Gene Aliases: HC; TC-1; TC1; TCI; TCN1
UniProt ID: (Human) P20061
Entrez Gene ID: (Human) 6947