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Immunogen sequence: MRHLGAFLF LLGVLGALTE MCEIPEMDSH LVEKLGQHLL PWMDRLSLEH LNPSIYVGLR LSSLQAGTKE DLYLHSLKLG YQQCLLGSAF SEDDGDCQGK PSMGQLALYL LALRANWHDH KGHPHTSYYQ YGLGILALCL HQKRVHDSVV DKLLYAVEPF HQGHHSVDTA AMAGLAFTCL KRSNFNPGRR QRITMAIRTV REEILKAQTP EGHFGNVYST PLALQFLMTS PMRGAELGTA CLKARVALLA SLQDGAFQNA LMISQLLPVL NHKTYIDLIF PDCLAPRVML EPAAETIPQT QEIISVTLQV LSLLPPYRQS ISVLAGSTVE DVLKKAHELG GFTYETQASL SGPYLTSVMG KAAGEREFWQ LLRDPNTPLL QGIADYRPKD GETIELRLVS W (1-400 aa encoded by BC011239)
This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.
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Protein Aliases: macrocytic anemia; TC II; TC TC D22S676; TC-2; TCII; Transcobalamin II; transcobalamin II; macrocytic anemia; Transcobalamin-2; vitamin B12-binding protein 2
Gene Aliases: AW208754; D22S676; D22S750; II; TC; TC II; TC-2; TC2; TCII; Tcn-2; TCN2; Tcn2p
UniProt ID: (Human) P20062, (Mouse) O88968
Entrez Gene ID: (Human) 6948, (Mouse) 21452, (Rat) 64365
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