This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.
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Protein Aliases: macrocytic anemia; TC II; TC-2; Transcobalamin II; transcobalamin II; macrocytic anemia; Transcobalamin-2; vitamin B12-binding protein 2
Gene Aliases: D22S676; D22S750; II; TC; TC II; TC-2; TC2; TCII; TCN2
UniProt ID: (Human) P20062
Entrez Gene ID: (Human) 6948