Proteintech

TCTN2 Polyclonal Antibody

TCTN2 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 5

TCTN2 Antibody (17053-1-AP) in ICC/IF

IF result from Dr. Corbit, Kevin. anti-TCTN2 (17053-1-AP) mark the transition zone of Human hTERT-RPE1 cells.

TCTN2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

TCTN2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

17053-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 5 publications 5 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TCTN2 Fusion Protein Ag10725 (351-697 aa encoded by BC009112)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: VIYEEATDL DKFITNTETP LNNGSTPRIV NVEEHYIFKW NNNTISEINV KIFRAEINAH QKGIMTQRFV VKFLSYNSGN EEELSGNPGY QLGKPVRALN INRMNNVTTL HLWQSAGRGL CTSATFKPIL FGENVLSGCL LEVGINENCT QLRENAVERL DSLIQATHVA MRGNSDYADL SDGWLEIIRV DAPDPGADPL ASSVNGMCLD IPAHLSIRIL ISDAGAVEGI TQQEILGVET RFSSVNWQYQ CGLTCEHKAD LLPISASVQF IKIPAQLPHP LTRFQINYTE YDCNRNEVCW PQLLYPWTQY YQGELHSQCV AKGLLLLLFL TLALFLSNPW TRICKAYS (351-697 aa encoded by BC009112)

Target Information

TCTN2 is a member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. While the expression pattern and function of TCTN2 is not known, it is 49% similar to TCTN1. TCTN1 is expressed during embryonic development in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13. 5 and E16. 5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Comparison of Ciliary Targeting of Two Rhodopsin-Like GPCRs: Role of C-Terminal Localization Sequences in Relation to Cilium Type.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Chadha A,Paniagua AE,Williams DS

Wed Sep 08 00:00:00 UTC 2021

Phosphorylation of CEP83 by TTBK2 is necessary for cilia initiation.

The Journal of cell biology

Lo CH,Lin IH,Yang TT,Huang YC,Tanos BE,Chou PC,Chang CW,Tsay YG,Liao JC,Wang WJ

Mon Oct 07 00:00:00 UTC 2019

Cell type-specific regulation of ciliary transition zone assembly in vertebrates.

The EMBO journal

Wiegering A,Dildrop R,Kalfhues L,Spychala A,Kuschel S,Lier JM,Zobel T,Dahmen S,Leu T,Struchtrup A,Legendre F,Vesque C,Schneider-Maunoury S,Saunier S,Rüther U,Gerhardt C

Tue May 15 00:00:00 UTC 2018

Cell type-specific regulation of ciliary transition zone assembly in vertebrates.

The EMBO journal

Wiegering A,Dildrop R,Kalfhues L,Spychala A,Kuschel S,Lier JM,Zobel T,Dahmen S,Leu T,Struchtrup A,Legendre F,Vesque C,Schneider-Maunoury S,Saunier S,Rüther U,Gerhardt C

Tue May 15 00:00:00 UTC 2018

Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis.

Nature communications

Tu HQ,Qin XH,Liu ZB,Song ZQ,Hu HB,Zhang YC,Chang Y,Wu M,Huang Y,Bai YF,Wang G,Han QY,Li AL,Zhou T,Liu F,Zhang XM,Li HY

Tue Dec 11 00:00:00 UTC 2018

CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base.

Nature cell biology

Wang WJ,Tay HG,Soni R,Perumal GS,Goll MG,Macaluso FP,Asara JM,Amack JD,Tsou MF

Sat Jun 01 00:00:00 UTC 2013

CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base.

Nature cell biology

Wang WJ,Tay HG,Soni R,Perumal GS,Goll MG,Macaluso FP,Asara JM,Amack JD,Tsou MF

Sat Jun 01 00:00:00 UTC 2013

CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base.

Nature cell biology

Wang WJ,Tay HG,Soni R,Perumal GS,Goll MG,Macaluso FP,Asara JM,Amack JD,Tsou MF

Sat Jun 01 00:00:00 UTC 2013

CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base.

Nature cell biology

Wang WJ,Tay HG,Soni R,Perumal GS,Goll MG,Macaluso FP,Asara JM,Amack JD,Tsou MF

Sat Jun 01 00:00:00 UTC 2013

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

Cell

Sang L,Miller JJ,Corbit KC,Giles RH,Brauer MJ,Otto EA,Baye LM,Wen X,Scales SJ,Kwong M,Huntzicker EG,Sfakianos MK,Sandoval W,Bazan JF,Kulkarni P,Garcia-Gonzalo FR,Seol AD,O'Toole JF,Held S,Reutter HM,Lane WS,Rafiq MA,Noor A,Ansar M,Devi AR,Sheffield VC,Slusarski DC,Vincent JB,Doherty DA,Hildebrandt F,Reiter JF,Jackson PK

Fri May 13 00:00:00 UTC 2011

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

Cell

Fri May 13 00:00:00 UTC 2011

A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.

Nature genetics

Garcia-Gonzalo FR,Corbit KC,Sirerol-Piquer MS,Ramaswami G,Otto EA,Noriega TR,Seol AD,Robinson JF,Bennett CL,Josifova DJ,García-Verdugo JM,Katsanis N,Hildebrandt F,Reiter JF

Sun Jul 03 00:00:00 UTC 2011

A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.

Nature genetics

Garcia-Gonzalo FR,Corbit KC,Sirerol-Piquer MS,Ramaswami G,Otto EA,Noriega TR,Seol AD,Robinson JF,Bennett CL,Josifova DJ,García-Verdugo JM,Katsanis N,Hildebrandt F,Reiter JF

Sun Jul 03 00:00:00 UTC 2011

A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.

Nature genetics

Garcia-Gonzalo FR,Corbit KC,Sirerol-Piquer MS,Ramaswami G,Otto EA,Noriega TR,Seol AD,Robinson JF,Bennett CL,Josifova DJ,García-Verdugo JM,Katsanis N,Hildebrandt F,Reiter JF

Sun Jul 03 00:00:00 UTC 2011

A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.

Nature genetics

Garcia-Gonzalo FR,Corbit KC,Sirerol-Piquer MS,Ramaswami G,Otto EA,Noriega TR,Seol AD,Robinson JF,Bennett CL,Josifova DJ,García-Verdugo JM,Katsanis N,Hildebrandt F,Reiter JF

Sun Jul 03 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: tectonic 2; Tectonic-2

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Gene Aliases: 4432405B04Rik; C12orf38; JBTS24; MKS8; TCTN2; TECT2

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UniProt ID: (Human) Q96GX1, (Rat) Q3B7D3, (Mouse) Q2MV57

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Entrez Gene ID: (Human) 79867, (Rat) 689779, (Mouse) 67978

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Function(s)

hydrogen ion transmembrane transporter activity protein binding

Process(es)

smoothened signaling pathway ATP hydrolysis coupled proton transport cilium assembly cilium morphogenesis cell projection organization

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TCTN2 Polyclonal Antibody

TCTN2 Antibody (17053-1-AP) in ICC/IF

Product Details

17053-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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