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Proteintech
TCTN2 Polyclonal Antibody
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Product Details
17053-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TCTN2 Fusion Protein Ag10725 (351-697 aa encoded by BC009112)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Amount
34.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: VIYEEATDL DKFITNTETP LNNGSTPRIV NVEEHYIFKW NNNTISEINV KIFRAEINAH QKGIMTQRFV VKFLSYNSGN EEELSGNPGY QLGKPVRALN INRMNNVTTL HLWQSAGRGL CTSATFKPIL FGENVLSGCL LEVGINENCT QLRENAVERL DSLIQATHVA MRGNSDYADL SDGWLEIIRV DAPDPGADPL ASSVNGMCLD IPAHLSIRIL ISDAGAVEGI TQQEILGVET RFSSVNWQYQ CGLTCEHKAD LLPISASVQF IKIPAQLPHP LTRFQINYTE YDCNRNEVCW PQLLYPWTQY YQGELHSQCV AKGLLLLLFL TLALFLSNPW TRICKAYS (351-697 aa encoded by BC009112)
Target Information
TCTN2 is a member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. While the expression pattern and function of TCTN2 is not known, it is 49% similar to TCTN1. TCTN1 is expressed during embryonic development in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13. 5 and E16. 5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: tectonic 2; Tectonic-2; transmembrane protein; unnamed protein product
Gene Aliases: 4432405B04Rik; C12orf38; JBTS24; MKS8; TCTN2; TECT2
UniProt ID: (Human) Q96GX1, (Rat) Q3B7D3, (Mouse) Q2MV57
Entrez Gene ID: (Human) 79867, (Rat) 689779, (Mouse) 67978
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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