Recommended positive controls: HepG2.
Predicted reactivity: Rhesus Monkey (97%), Chimpanzee (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
TDE1, tumor differentially expressed protein 1, is a multi-pass membrane protein also known as serine incorporator 3. Also found on the membranes of the Golgi apparatus within cells, TDE1 is highly expressed in neuronal populations but is also found in thymus, kidney, liver and testis. Expression levels of TDE1 in tumors can be as much as tenfold the amount found in normal tissue of the same type. This increased expression implicates TDE1 as being involved in the cellular transformation from normal to malignant tissue. It is believed TDE1 contributes to oncogenesis by partially protecting cells from serum starvation and etoposide-induced apoptosis. The mechanism through which TDE1 protects cells is poorly understood, but may involve aberrant methylation of TDE1 complexes.
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Protein Aliases: Serine incorporator 3; Tumor differentially expressed protein 1
Gene Aliases: AIGP1; DIFF33; SBBI99; SERINC3; TDE; TDE1; TMS-1
UniProt ID: (Human) Q13530
Entrez Gene ID: (Human) 10955
Molecular Function: protein-binding activity modulator