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Proteintech
TDO2 Polyclonal Antibody
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Product Details
15880-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TDO2 Fusion Protein Ag8642 (55-406 aa encoded by BC005355)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: QELQSETKG NKIHDEHLFI ITHQAYELWF KQILWELDSV REIFQNGHVR DERNMLKVVS RMHRVSVILK LLVQQFSILE TMTALDFNDF REYLSPASGF QSLQFRLLEN KIGVLQNMRV PYNRRHYRDN FKGEENELLL KSEQEKTLLE LVEAWLERTP GLEPHGFNFW GKLEKNITRG LEEEFIRIQA KEESEEKEEQ VAEFQKQKEV LLSLFDEKRH EHLLSKGERR LSYRALQGAL MIYFYREEPR FQVPFQLLTS LMDIDSLMTK WRYNHVCMVH RMLGSKAGTG GSSGYHYLRS TVSDRYKVFV DLFNLSTYLI PRHWIPKMNP TIHKFLYTAE YCDSSYFSSD ESD (55-406 aa encoded by BC005355)
Target Information
Tryptophan 2,3-dioxygenase (TDO2) is an enzyme encoded by the TDO2 gene, predominantly expressed in the liver and playing a crucial role in tryptophan metabolism through the kynurenine pathway. TDO2 catalyzes the first and rate-limiting step of this pathway, converting tryptophan into N-formylkynurenine. This metabolic process is vital for maintaining systemic tryptophan homeostasis and regulating its availability for protein synthesis and serotonin production. Beyond its metabolic function, TDO2 is involved in modulating immune responses. It contributes to immune tolerance by depleting tryptophan, thereby inhibiting T cell proliferation and promoting regulatory T cell development. Recent research has identified TDO2's role in cancer, particularly in shaping the tumor microenvironment and facilitating immune escape mechanisms through tryptophan catabolism. Its expression is upregulated in several cancers, including gliomas, correlating with tumor severity and patient prognosis. TDO2 and its associated pathways have become therapeutic targets in cancer immunotherapy due to their influence on immune system modulation and metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: TDO; tdo variant1; tdo variant2; TDO {ECO:0000255|HAMAP-Rule:MF_03020}; TDO2; TO; TO {ECO:0000255|HAMAP-Rule:MF_03020}; TRPO; TRPO {ECO:0000255|HAMAP-Rule:MF_03020}; Tryptamin 2,3-dioxygenase; tryptamin 2,3-dioxygenase {ECO:0000255|HAMAP-Rule:MF_03020}; Tryptophan 2,3-dioxygenase; tryptophan 2,3-dioxygenase A; tryptophan 2,3-dioxygenase {ECO:0000255|HAMAP-Rule:MF_03020}; Tryptophan oxygenase; tryptophan oxygenase {ECO:0000255|HAMAP-Rule:MF_03020}; Tryptophan pyrrolase; tryptophan pyrrolase {ECO:0000255|HAMAP-Rule:MF_03020}; tryptophan-2,3-dioxygenase; tryptophan-23-dioxygenase; Tryptophanase; tryptophanase {ECO:0000255|HAMAP-Rule:MF_03020}
Gene Aliases: AA407491; chky; TDO; TDO2; TO; TPH2; TRPO
UniProt ID: (Human) P48775, (Mouse) P48776, (Rat) P21643
Entrez Gene ID: (Human) 6999, (Mouse) 56720, (Rat) 64206
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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