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Invitrogen
TDO2 Polyclonal Antibody
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Product Details
PA5-116558
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic Peptide
Conjugate
Form
Liquid
Concentration
3.08 mg/mL
Amount
308 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: LO2, U-87MG, Mouse uterus, Rat liver
Immunogen sequence: VLQNMRVPYN RRHYRDNF
Target Information
Tryptophan 2,3-dioxygenase (TDO2) is an enzyme encoded by the TDO2 gene, predominantly expressed in the liver and playing a crucial role in tryptophan metabolism through the kynurenine pathway. TDO2 catalyzes the first and rate-limiting step of this pathway, converting tryptophan into N-formylkynurenine. This metabolic process is vital for maintaining systemic tryptophan homeostasis and regulating its availability for protein synthesis and serotonin production. Beyond its metabolic function, TDO2 is involved in modulating immune responses. It contributes to immune tolerance by depleting tryptophan, thereby inhibiting T cell proliferation and promoting regulatory T cell development. Recent research has identified TDO2's role in cancer, particularly in shaping the tumor microenvironment and facilitating immune escape mechanisms through tryptophan catabolism. Its expression is upregulated in several cancers, including gliomas, correlating with tumor severity and patient prognosis. TDO2 and its associated pathways have become therapeutic targets in cancer immunotherapy due to their influence on immune system modulation and metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: TDO; tdo variant1; tdo variant2; TDO {ECO:0000255|HAMAP-Rule:MF_03020}; TO; TO {ECO:0000255|HAMAP-Rule:MF_03020}; TRPO; TRPO {ECO:0000255|HAMAP-Rule:MF_03020}; Tryptamin 2,3-dioxygenase; tryptamin 2,3-dioxygenase {ECO:0000255|HAMAP-Rule:MF_03020}; Tryptophan 2,3-dioxygenase; tryptophan 2,3-dioxygenase A; tryptophan 2,3-dioxygenase {ECO:0000255|HAMAP-Rule:MF_03020}; Tryptophan oxygenase; tryptophan oxygenase {ECO:0000255|HAMAP-Rule:MF_03020}; Tryptophan pyrrolase; tryptophan pyrrolase {ECO:0000255|HAMAP-Rule:MF_03020}; tryptophan-2,3-dioxygenase; tryptophan-23-dioxygenase; Tryptophanase; tryptophanase {ECO:0000255|HAMAP-Rule:MF_03020}; unnamed protein product
Gene Aliases: AA407491; chky; HYPTRP; TDO; TDO2; TO; TPH2; TRPO
UniProt ID: (Human) P48775, (Mouse) P48776, (Rat) P21643
Entrez Gene ID: (Human) 6999, (Mouse) 56720, (Rat) 64206
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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