Product References
Viral vector gene delivery of the novel chaperone protein SRCP1 to modify insoluble protein in in vitro and in vivo models of ALS.
Gene therapy
Luecke IW,Lin G,Santarriaga S,Scaglione KM,Ebert AD
Thu Jun 01 00:00:00 UTC 2023
Deficiency of Perry syndrome-associated p150Glued in midbrain dopaminergic neurons leads to progressive neurodegeneration and endoplasmic reticulum abnormalities.
NPJ Parkinson's disease
Yu J,Yang X,Zheng J,Sgobio C,Sun L,Cai H
Tue Mar 07 00:00:00 UTC 2023
Endogenous retroviruses and TDP-43 proteinopathy form a sustaining feedback driving intercellular spread of Drosophila neurodegeneration.
Nature communications
Chang YH,Dubnau J
Tue Feb 21 00:00:00 UTC 2023
Amyotrophic lateral sclerosis with TDP-43 abnormalities exhibiting globular glial tau inclusions in frontotemporal lobes and pallido-nigral system.
Neuropathology : official journal of the Japanese Society of Neuropathology
Yagita K,Sasagasako N,Koyama S,Noguchi H,Honda H
Wed Feb 01 00:00:00 UTC 2023
Tuberous sclerosis complex is associated with a novel human tauopathy.
Acta neuropathologica
Hwang JL,Perloff OS,Gaus SE,Benitez C,Alquezar C,Cosme CQ,Nana AL,Vatsavayai SC,Ramos EM,Geschwind DH,Miller BL,Kao AW,Seeley WW
Sun Jan 01 00:00:00 UTC 2023
TDP-43 pathology and functional deficits in wild-type and ALS/FTD mutant cyclin F mouse models.
Neuropathology and applied neurobiology
van Hummel A,Sabale M,Przybyla M,van der Hoven J,Chan G,Feiten AF,Chung RS,Ittner LM,Ke YD
Sat Apr 01 00:00:00 UTC 2023
Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice.
Molecular therapy. Nucleic acids
Takeuchi T,Maeta K,Ding X,Oe Y,Takeda A,Inoue M,Nagano S,Fujihara T,Matsuda S,Ishigaki S,Sahashi K,Minakawa EN,Mochizuki H,Neya M,Sobue G,Nagai Y
Tue Mar 14 00:00:00 UTC 2023
Study of Ubiquitin Pathway Genes in a French Population with Amyotrophic Lateral Sclerosis: Focus on HECW1 Encoding the E3 Ligase NEDL1.
International journal of molecular sciences
Haouari S,Andres CR,Lanznaster D,Marouillat S,Brulard C,Dangoumau A,Ung D,Veyrat-Durebex C,Laumonnier F,Blasco H,Couratier P,Corcia P,Vourc'h P
Mon Jan 09 00:00:00 UTC 2023
Study of Ubiquitin Pathway Genes in a French Population with Amyotrophic Lateral Sclerosis: Focus on HECW1 Encoding the E3 Ligase NEDL1.
International journal of molecular sciences
Haouari S,Andres CR,Lanznaster D,Marouillat S,Brulard C,Dangoumau A,Ung D,Veyrat-Durebex C,Laumonnier F,Blasco H,Couratier P,Corcia P,Vourc'h P
Mon Jan 09 00:00:00 UTC 2023
Elevated nuclear TDP-43 induces constitutive exon skipping.
bioRxiv : the preprint server for biology
Carmen-Orozco RP,Tsao W,Ye Y,Sinha IR,Chang K,Trinh V,Chung W,Bowden K,Troncoso JC,Blackshaw S,Hayes LR,Sun S,Wong PC,Ling JP
Fri May 12 00:00:00 UTC 2023
Elevated nuclear TDP-43 induces constitutive exon skipping.
bioRxiv : the preprint server for biology
Carmen-Orozco RP,Tsao W,Ye Y,Sinha IR,Chang K,Trinh V,Chung W,Bowden K,Troncoso JC,Blackshaw S,Hayes LR,Sun S,Wong PC,Ling JP
Fri May 12 00:00:00 UTC 2023
Elevated nuclear TDP-43 induces constitutive exon skipping.
bioRxiv : the preprint server for biology
Carmen-Orozco RP,Tsao W,Ye Y,Sinha IR,Chang K,Trinh V,Chung W,Bowden K,Troncoso JC,Blackshaw S,Hayes LR,Sun S,Wong PC,Ling JP
Fri May 12 00:00:00 UTC 2023
Elevated nuclear TDP-43 induces constitutive exon skipping.
bioRxiv : the preprint server for biology
Carmen-Orozco RP,Tsao W,Ye Y,Sinha IR,Chang K,Trinh V,Chung W,Bowden K,Troncoso JC,Blackshaw S,Hayes LR,Sun S,Wong PC,Ling JP
Fri May 12 00:00:00 UTC 2023
Increased oligomeric TDP-43 in the plasma of Korean frontotemporal dementia patients with semantic dementia.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Jamerlan AM,Shim KH,Youn YC,Teunissen C,An SSA,Scheltens P,Kim S
Fri Sep 01 00:00:00 UTC 2023
Looking for answers far away from the soma-the (un)known axonal functions of TDP-43, and their contribution to early NMJ disruption in ALS.
Molecular neurodegeneration
Ionescu A,Altman T,Perlson E
Wed May 31 00:00:00 UTC 2023
Sedimentation Assays to Assess the Impact of Posttranslational Modifications on Phase Separation of RNA-Binding Proteins In Vitro and In Cells.
Methods in molecular biology (Clifton, N.J.)
Gruijs da Silva LA,Dormann D
Mon Oct 17 00:00:00 UTC 2022
Argyrophilic grain disease is common in older adults and may be a risk factor for suicide: a study of Japanese forensic autopsy cases.
Translational neurodegeneration
Yoshida K,Hata Y,Ichimata S,Okada K,Nishida N
Sat Apr 01 00:00:00 UTC 2023
Distinctive chaperonopathy in skeletal muscle associated with the dominant variant in DNAJB4.
Acta neuropathologica
Inoue M,Noguchi S,Inoue YU,Iida A,Ogawa M,Bengoechea R,Pittman SK,Hayashi S,Watanabe K,Hosoi Y,Sano T,Takao M,Oya Y,Takahashi Y,Miyajima H,Weihl CC,Inoue T,Nishino I
Wed Feb 01 00:00:00 UTC 2023
Rapid nuclear deadenylation of mammalian messenger RNA.
iScience
Alles J,Legnini I,Pacelli M,Rajewsky N
Fri Jan 20 00:00:00 UTC 2023
Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines.
Science advances
Licht-Murava A,Meadows SM,Palaguachi F,Song SC,Jackvony S,Bram Y,Zhou C,Schwartz RE,Froemke RC,Orr AL,Orr AG
Fri Apr 21 00:00:00 UTC 2023
Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines.
Science advances
Licht-Murava A,Meadows SM,Palaguachi F,Song SC,Jackvony S,Bram Y,Zhou C,Schwartz RE,Froemke RC,Orr AL,Orr AG
Fri Apr 21 00:00:00 UTC 2023
Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines.
Science advances
Licht-Murava A,Meadows SM,Palaguachi F,Song SC,Jackvony S,Bram Y,Zhou C,Schwartz RE,Froemke RC,Orr AL,Orr AG
Fri Apr 21 00:00:00 UTC 2023
Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines.
Science advances
Licht-Murava A,Meadows SM,Palaguachi F,Song SC,Jackvony S,Bram Y,Zhou C,Schwartz RE,Froemke RC,Orr AL,Orr AG
Fri Apr 21 00:00:00 UTC 2023
Loss of C9orf72 perturbs the Ran-GTPase gradient and nucleocytoplasmic transport, generating compositionally diverse Importin β-1 granules.
Cell reports
McGoldrick P,Lau A,You Z,Durcan TM,Robertson J
Tue Mar 28 00:00:00 UTC 2023
A fluid biomarker reveals loss of TDP-43 splicing repression in pre-symptomatic ALS.
bioRxiv : the preprint server for biology
Irwin KE,Jasin P,Braunstein KE,Sinha I,Bowden KD,Moghekar A,Oh ES,Raitcheva D,Bartlett D,Berry JD,Traynor B,Ling JP,Wong PC
Tue Jan 24 00:00:00 UTC 2023
Hyperphosphorylated Tau in Mesial Temporal Lobe Epilepsy: a Neuropathological and Cognitive Study.
Molecular neurobiology
Toscano ECB,Vieira ÉLM,Grinberg LT,Rocha NP,Brant JAS,Paradela RS,Giannetti AV,Suemoto CK,Leite REP,Nitrini R,Rachid MA,Teixeira AL
Sat Apr 01 00:00:00 UTC 2023
The influence of age and sex on the absolute cell numbers of the human brain cerebral cortex.
Cerebral cortex (New York, N.Y. : 1991)
Castro-Fonseca E,Morais V,da Silva CG,Wollner J,Freitas J,Mello-Neto AF,Oliveira LE,de Oliveira VC,Leite REP,Alho AT,Rodriguez RD,Ferretti-Rebustini REL,Suemoto CK,Jacob-Filho W,Nitrini R,Pasqualucci CA,Grinberg LT,Tovar-Moll F,Lent R
Tue Jun 20 00:00:00 UTC 2023
Macroglossia in rapidly progressive inclusion body myositis.
Neuropathology : official journal of the Japanese Society of Neuropathology
Yamasaki Y,Mukaino A,Yamashita S,Takeuchi Y,Tawara N,Yoshida R,Honda Y,Yamashita T,Kakimoto A,Ueyama H,Ando Y
Thu Jun 01 00:00:00 UTC 2023
ILF3 prion-like domain regulates gene expression and fear memory under chronic stress.
iScience
Yamashita A,Shichino Y,Fujii K,Koshidaka Y,Adachi M,Sasagawa E,Mito M,Nakagawa S,Iwasaki S,Takao K,Shiina N
Fri Mar 17 00:00:00 UTC 2023
Codon-optimized TDP-43 mediates neurodegeneration in a Drosophila model of ALS/FTLD.
Frontiers in genetics
Yusuff T,Chang YC,Sang TK,Jackson GR,Chatterjee S
Tue Mar 28 00:00:00 UTC 2023
Codon-optimized TDP-43 mediates neurodegeneration in a Drosophila model of ALS/FTLD.
Frontiers in genetics
Yusuff T,Chang YC,Sang TK,Jackson GR,Chatterjee S
Tue Mar 28 00:00:00 UTC 2023
Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD.
Molecular psychiatry
Luan W,Wright AL,Brown-Wright H,Le S,San Gil R,Madrid San Martin L,Ling K,Jafar-Nejad P,Rigo F,Walker AK
Thu Jun 01 00:00:00 UTC 2023
Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD.
Molecular psychiatry
Luan W,Wright AL,Brown-Wright H,Le S,San Gil R,Madrid San Martin L,Ling K,Jafar-Nejad P,Rigo F,Walker AK
Thu Jun 01 00:00:00 UTC 2023
Preclinical investigation in FAAH inhibition as a neuroprotective therapy for frontotemporal dementia using TDP-43 transgenic male mice.
Journal of neuroinflammation
Santos-García I,Rodríguez-Cueto C,Villegas P,Piscitelli F,Lauritano A,Shen CJ,Di Marzo V,Fernández-Ruiz J,de Lago E
Sat May 06 00:00:00 UTC 2023
Disruption of ER ion homeostasis maintained by an ER anion channel CLCC1 contributes to ALS-like pathologies.
Cell research
Guo L,Mao Q,He J,Liu X,Piao X,Luo L,Hao X,Yu H,Song Q,Xiao B,Fan D,Gao Z,Jia Y
Sat Jul 01 00:00:00 UTC 2023
VCP-related myopathy: a case series and a review of literature.
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology
Iannibelli E,Gibertini S,Cheli M,Blasevich F,Cavaliere A,Riolo G,Ruggieri A,Maggi L
Tue Apr 25 00:00:00 UTC 2023
Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage.
Nature neuroscience
Kumar ST,Nazarov S,Porta S,Maharjan N,Cendrowska U,Kabani M,Finamore F,Xu Y,Lee VM,Lashuel HA
Thu Jun 01 00:00:00 UTC 2023
Psychotic symptoms in frontotemporal dementia with TDP-43 tend to be associated with type B pathology.
Neuropathology and applied neurobiology
Hirsch-Reinshagen V,Hercher C,Vila-Rodriguez F,Neumann M,Rademakers R,Honer WG,Hsiung GR,Mackenzie IR
Tue Aug 01 00:00:00 UTC 2023
Accumulation of TMEM106B C-terminal fragments in neurodegenerative disease and aging.
Acta neuropathologica
Perneel J,Neumann M,Heeman B,Cheung S,Van den Broeck M,Wynants S,Baker M,Vicente CT,Faura J,Rademakers R,Mackenzie IRA
Wed Mar 01 00:00:00 UTC 2023
Progranulin Deficiency Induces Mitochondrial Dysfunction in Frontotemporal Lobar Degeneration with TDP-43 Inclusions.
Antioxidants (Basel, Switzerland)
Rodríguez-Periñán G,de la Encarnación A,Moreno F,López de Munain A,Martínez A,Martín-Requero Á,Alquézar C,Bartolomé F
Sat Feb 25 00:00:00 UTC 2023
Severe cerebrovascular pathology of the first supercentenarian to be autopsied in the world.
Neuropathology : official journal of the Japanese Society of Neuropathology
Iwase T,Yoshida M,Hashizume Y,Inagaki T,Iwasaki Y
Sat Apr 01 00:00:00 UTC 2023
A New Mouse Model of Giant Axonal Neuropathy with Overt Phenotypes and Neurodegeneration Driven by Neurofilament Disorganization.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Nath B,Julien JP
Wed May 31 00:00:00 UTC 2023
Ataxin-2 polyglutamine expansions aberrantly sequester TDP-43, drive ribonucleoprotein condensate transport dysfunction and suppress local translation.
bioRxiv : the preprint server for biology
Wijegunawardana D,Vishal SS,Venkatesh N,Gopal PP
Wed Feb 15 00:00:00 UTC 2023
SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers.
Nature cancer
Shi L,Shen W,Davis MI,Kong K,Vu P,Saha SK,Adil R,Kreuzer J,Egan R,Lee TD,Greninger P,Shrimp JH,Zhao W,Wei TY,Zhou M,Eccleston J,Sussman J,Manocha U,Weerasekara V,Kondo H,Vijay V,Wu MJ,Kearney SE,Ho J,McClanaghan J,Murchie E,Crowther GS,Patnaik S,Boxer MB,Shen M,Ting DT,Kim WY,Stanger BZ,Deshpande V,Ferrone CR,Benes CH,Haas W,Hall MD,Bardeesy N
Wed Mar 01 00:00:00 UTC 2023
SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers.
Nature cancer
Shi L,Shen W,Davis MI,Kong K,Vu P,Saha SK,Adil R,Kreuzer J,Egan R,Lee TD,Greninger P,Shrimp JH,Zhao W,Wei TY,Zhou M,Eccleston J,Sussman J,Manocha U,Weerasekara V,Kondo H,Vijay V,Wu MJ,Kearney SE,Ho J,McClanaghan J,Murchie E,Crowther GS,Patnaik S,Boxer MB,Shen M,Ting DT,Kim WY,Stanger BZ,Deshpande V,Ferrone CR,Benes CH,Haas W,Hall MD,Bardeesy N
Wed Mar 01 00:00:00 UTC 2023
Suppression of TDP-43 aggregation by artificial peptide binder targeting to its low complexity domain.
Biochemical and biophysical research communications
Kamagata K,Kanbayashi S,Koda S,Kadotani A,Ubukata O,Tashima T
Sun Jun 25 00:00:00 UTC 2023
MicroRNA-183-5p regulates TAR DNA-binding protein 43 neurotoxicity via SQSTM1/p62 in amyotrophic lateral sclerosis.
Journal of neurochemistry
Kim HC,Zhang Y,King PH,Lu L
Wed Mar 01 00:00:00 UTC 2023
Tandem detergent-extraction and immunoprecipitation of proteinopathy: Scalable enrichment of ALS-associated TDP-43 aggregates.
iScience
Evangelista BA,Cahalan SR,Ragusa JV,Mordant A,Necarsulmer JC,Perna RJ,Ajit T,White K,Barker NK,Tian X,Cohen S,Meeker R,Herring LE,Cohen TJ
Fri May 19 00:00:00 UTC 2023
Tandem detergent-extraction and immunoprecipitation of proteinopathy: Scalable enrichment of ALS-associated TDP-43 aggregates.
iScience
Evangelista BA,Cahalan SR,Ragusa JV,Mordant A,Necarsulmer JC,Perna RJ,Ajit T,White K,Barker NK,Tian X,Cohen S,Meeker R,Herring LE,Cohen TJ
Fri May 19 00:00:00 UTC 2023
N protein of PEDV plays chess game with host proteins by selective autophagy.
Autophagy
Zhai X,Kong N,Zhang Y,Song Y,Qin W,Yang X,Ye C,Ye M,Tong W,Liu C,Zheng H,Yu H,Zhang W,Yang X,Zhang G,Tong G,Shan T
Tue Aug 01 00:00:00 UTC 2023
Autophagic vacuolar myopathy involving the phenotype of spinocerebellar ataxia type 3.
Neuropathology : official journal of the Japanese Society of Neuropathology
Li J,Peng Y,Tang J,Li M,Zhu M,Zhou M,Fang P,Hong D
Sat Apr 01 00:00:00 UTC 2023
CircTmeff1 Promotes Muscle Atrophy by Interacting with TDP-43 and Encoding A Novel TMEFF1-339aa Protein.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Chen R,Yang T,Jin B,Xu W,Yan Y,Wood N,Lehmann HI,Wang S,Zhu X,Yuan W,Chen H,Liu Z,Li G,Bowen TS,Li J,Xiao J
Thu Jun 01 00:00:00 UTC 2023
CircTmeff1 Promotes Muscle Atrophy by Interacting with TDP-43 and Encoding A Novel TMEFF1-339aa Protein.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Chen R,Yang T,Jin B,Xu W,Yan Y,Wood N,Lehmann HI,Wang S,Zhu X,Yuan W,Chen H,Liu Z,Li G,Bowen TS,Li J,Xiao J
Thu Jun 01 00:00:00 UTC 2023
SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS.
Cell stem cell
Linares GR,Li Y,Chang WH,Rubin-Sigler J,Mendonca S,Hong S,Eoh Y,Guo W,Huang YH,Chang J,Tu S,Dorjsuren N,Santana M,Hung ST,Yu J,Perez J,Chickering M,Cheng TY,Huang CC,Lee SJ,Deng HJ,Bach KT,Gray K,Subramanyam V,Rosenfeld J,Alworth SV,Goodarzi H,Ichida JK
Thu Feb 02 00:00:00 UTC 2023
TDP-43 knockdown in mouse model of ALS leads to dsRNA deposition, gliosis, and neurodegeneration in the spinal cord.
Cerebral cortex (New York, N.Y. : 1991)
Milstead RA,Link CD,Xu Z,Hoeffer CA
Tue May 09 00:00:00 UTC 2023
Quantitative proteomics of tau and Aβ in detergent fractions from Alzheimer's disease brains.
Journal of neurochemistry
Mukherjee S,Dubois C,Perez K,Varghese S,Birchall IE,Leckey M,Davydova N,McLean C,Nisbet RM,Roberts BR,Li QX,Masters CL,Streltsov VA
Wed Feb 01 00:00:00 UTC 2023
Development of FRET and Stress Granule Dual-Based System to Screen for Viral 3C Protease Inhibitors.
Molecules (Basel, Switzerland)
Zhang J,Jiang Y,Wu C,Zhou D,Gong J,Zhao T,Jin Z
Tue Mar 28 00:00:00 UTC 2023
Ballooned neurons in semi-recent severe traumatic brain injury.
Acta neuropathologica communications
Michaud J,Plu I,Parai J,Bourgault A,Tanguay C,Seilhean D,Woulfe J
Fri Mar 10 00:00:00 UTC 2023
Exosomal TAR DNA binding protein 43 profile in canine model of amyotrophic lateral sclerosis: a preliminary study in developing blood-based biomarker for neurodegenerative diseases.
Annals of medicine
Pfeiffer P,Coates JR,Esqueda YM,Kennedy A,Getchell K,McLenon M,Kosa E,Agbas A
Fri Dec 01 00:00:00 UTC 2023
Loss of TDP-43 function underlies hippocampal and cortical synaptic deficits in TDP-43 proteinopathies.
Molecular psychiatry
Ni J,Ren Y,Su T,Zhou J,Fu C,Lu Y,Li D,Zhao J,Li Y,Zhang Y,Fang Y,Liu N,Geng Y,Chen Y
Wed Feb 01 00:00:00 UTC 2023
Loss of TDP-43 function underlies hippocampal and cortical synaptic deficits in TDP-43 proteinopathies.
Molecular psychiatry
Ni J,Ren Y,Su T,Zhou J,Fu C,Lu Y,Li D,Zhao J,Li Y,Zhang Y,Fang Y,Liu N,Geng Y,Chen Y
Wed Feb 01 00:00:00 UTC 2023
Loss of TDP-43 function underlies hippocampal and cortical synaptic deficits in TDP-43 proteinopathies.
Molecular psychiatry
Ni J,Ren Y,Su T,Zhou J,Fu C,Lu Y,Li D,Zhao J,Li Y,Zhang Y,Fang Y,Liu N,Geng Y,Chen Y
Wed Feb 01 00:00:00 UTC 2023
Loss of TDP-43 function underlies hippocampal and cortical synaptic deficits in TDP-43 proteinopathies.
Molecular psychiatry
Ni J,Ren Y,Su T,Zhou J,Fu C,Lu Y,Li D,Zhao J,Li Y,Zhang Y,Fang Y,Liu N,Geng Y,Chen Y
Wed Feb 01 00:00:00 UTC 2023
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS.
Cell
Hung ST,Linares GR,Chang WH,Eoh Y,Krishnan G,Mendonca S,Hong S,Shi Y,Santana M,Kueth C,Macklin-Isquierdo S,Perry S,Duhaime S,Maios C,Chang J,Perez J,Couto A,Lai J,Li Y,Alworth SV,Hendricks E,Wang Y,Zlokovic BV,Dickman DK,Parker JA,Zarnescu DC,Gao FB,Ichida JK
Thu Feb 16 00:00:00 UTC 2023
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS.
Cell
Hung ST,Linares GR,Chang WH,Eoh Y,Krishnan G,Mendonca S,Hong S,Shi Y,Santana M,Kueth C,Macklin-Isquierdo S,Perry S,Duhaime S,Maios C,Chang J,Perez J,Couto A,Lai J,Li Y,Alworth SV,Hendricks E,Wang Y,Zlokovic BV,Dickman DK,Parker JA,Zarnescu DC,Gao FB,Ichida JK
Thu Feb 16 00:00:00 UTC 2023
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS.
Cell
Hung ST,Linares GR,Chang WH,Eoh Y,Krishnan G,Mendonca S,Hong S,Shi Y,Santana M,Kueth C,Macklin-Isquierdo S,Perry S,Duhaime S,Maios C,Chang J,Perez J,Couto A,Lai J,Li Y,Alworth SV,Hendricks E,Wang Y,Zlokovic BV,Dickman DK,Parker JA,Zarnescu DC,Gao FB,Ichida JK
Thu Feb 16 00:00:00 UTC 2023
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS.
Cell
Hung ST,Linares GR,Chang WH,Eoh Y,Krishnan G,Mendonca S,Hong S,Shi Y,Santana M,Kueth C,Macklin-Isquierdo S,Perry S,Duhaime S,Maios C,Chang J,Perez J,Couto A,Lai J,Li Y,Alworth SV,Hendricks E,Wang Y,Zlokovic BV,Dickman DK,Parker JA,Zarnescu DC,Gao FB,Ichida JK
Thu Feb 16 00:00:00 UTC 2023
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS.
Cell
Hung ST,Linares GR,Chang WH,Eoh Y,Krishnan G,Mendonca S,Hong S,Shi Y,Santana M,Kueth C,Macklin-Isquierdo S,Perry S,Duhaime S,Maios C,Chang J,Perez J,Couto A,Lai J,Li Y,Alworth SV,Hendricks E,Wang Y,Zlokovic BV,Dickman DK,Parker JA,Zarnescu DC,Gao FB,Ichida JK
Thu Feb 16 00:00:00 UTC 2023
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS.
Cell
Hung ST,Linares GR,Chang WH,Eoh Y,Krishnan G,Mendonca S,Hong S,Shi Y,Santana M,Kueth C,Macklin-Isquierdo S,Perry S,Duhaime S,Maios C,Chang J,Perez J,Couto A,Lai J,Li Y,Alworth SV,Hendricks E,Wang Y,Zlokovic BV,Dickman DK,Parker JA,Zarnescu DC,Gao FB,Ichida JK
Thu Feb 16 00:00:00 UTC 2023
Protocol for the Systematic Fixation, Circuit-Based Sampling, and Qualitative and Quantitative Neuropathological Analysis of Human Brain Tissue.
Methods in molecular biology (Clifton, N.J.)
Latimer CS,Melief EJ,Ariza-Torres J,Howard K,Keen AR,Keene LM,Schantz AM,Sytsma TM,Wilson AM,Grabowski TJ,Darvas M,O'Connor KD,Nolan AL,Edlow BL,Mac Donald CL,Keene CD
Tue Nov 22 00:00:00 UTC 2022
Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis.
Scientific reports
Bashore FM,Marquez AB,Chaikuad A,Howell S,Dunn AS,Beltran AA,Smith JL,Drewry DH,Beltran AS,Axtman AD
Fri Apr 14 00:00:00 UTC 2023
Neuronal activity regulates Matrin 3 abundance and function in a calcium-dependent manner through calpain-mediated cleavage and calmodulin binding.
Proceedings of the National Academy of Sciences of the United States of America
Malik AM,Wu JJ,Gillies CA,Doctrove QA,Li X,Huang H,Tank EHM,Shakkottai VG,Barmada S
Tue Apr 11 00:00:00 UTC 2023
Functional Characterization of a Familial ALS-Associated Missense TBK1 (p-Arg573Gly) Mutation in Patient-Derived Lymphoblasts.
International journal of molecular sciences
Porras G,Ruiz S,Maestro I,Borrego-Hernández D,Redondo AG,Martínez A,Martín-Requero Á
Thu Feb 02 00:00:00 UTC 2023
Atypical TDP-43 protein expression in an ALS pedigree carrying a p.Y374X truncation mutation in TARDBP.
Brain pathology (Zurich, Switzerland)
Cooper-Knock J,Julian TH,Feneberg E,Highley JR,Sidra M,Turner MR,Talbot K,Ansorge O,Allen SP,Moll T,Shelkovnikova T,Castelli L,Hautbergue GM,Hewitt C,Kirby J,Wharton SB,Mead RJ,Shaw PJ
Sun Jan 01 00:00:00 UTC 2023
Atypical TDP-43 protein expression in an ALS pedigree carrying a p.Y374X truncation mutation in TARDBP.
Brain pathology (Zurich, Switzerland)
Cooper-Knock J,Julian TH,Feneberg E,Highley JR,Sidra M,Turner MR,Talbot K,Ansorge O,Allen SP,Moll T,Shelkovnikova T,Castelli L,Hautbergue GM,Hewitt C,Kirby J,Wharton SB,Mead RJ,Shaw PJ
Sun Jan 01 00:00:00 UTC 2023
Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43.
Cellular and molecular life sciences : CMLS
Keating SS,Bademosi AT,San Gil R,Walker AK
Fri Mar 17 00:00:00 UTC 2023
Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43.
Cellular and molecular life sciences : CMLS
Keating SS,Bademosi AT,San Gil R,Walker AK
Fri Mar 17 00:00:00 UTC 2023
RNA methylation influences TDP43 binding and disease pathogenesis in models of amyotrophic lateral sclerosis and frontotemporal dementia.
Molecular cell
McMillan M,Gomez N,Hsieh C,Bekier M,Li X,Miguez R,Tank EMH,Barmada SJ
Thu Jan 19 00:00:00 UTC 2023
Neuropathology of central nervous system involvement in TTR amyloidosis.
Acta neuropathologica
Taipa R,Sousa L,Pinto M,Reis I,Rodrigues A,Oliveira P,Melo-Pires M,Coelho T
Sun Jan 01 00:00:00 UTC 2023
Stress granule assembly in vivo is deficient in the CNS of mutant TDP-43 ALS mice.
Human molecular genetics
Dubinski A,Gagné M,Peyrard S,Gordon D,Talbot K,Vande Velde C
Fri Jan 06 00:00:00 UTC 2023
Stress granule assembly in vivo is deficient in the CNS of mutant TDP-43 ALS mice.
Human molecular genetics
Dubinski A,Gagné M,Peyrard S,Gordon D,Talbot K,Vande Velde C
Fri Jan 06 00:00:00 UTC 2023
Aberrant neural activity in prefrontal pyramidal neurons lacking TDP-43 precedes neuron loss.
Progress in neurobiology
Liang B,Thapa R,Zhang G,Moffitt C,Zhang Y,Zhang L,Johnston A,Ruby HP,Barbera G,Wong PC,Zhang Z,Chen R,Lin DT,Li Y
Mon Aug 01 00:00:00 UTC 2022
An autopsy case of amyotrophic lateral sclerosis with striatonigral and pallidoluysian degeneration and cat's-eye-shaped neuronal nuclear inclusions.
Neuropathology : official journal of the Japanese Society of Neuropathology
Kon T,Mori F,Kinoshita I,Nakamura T,Nishijima H,Suzuki C,Goto S,Kijima H,Tomiyama M,Wakabayashi K
Mon Aug 01 00:00:00 UTC 2022
Importance of the Q/N-rich segment for protein stability of endogenous mouse TDP-43.
Scientific reports
Sato T,Oda K,Sakai S,Kato R,Yamamori S,Itakura M,Kodera Y,Nishizawa M,Sasaoka T,Onodera O,Yokoyama M
Fri Sep 02 00:00:00 UTC 2022
Importance of the Q/N-rich segment for protein stability of endogenous mouse TDP-43.
Scientific reports
Sato T,Oda K,Sakai S,Kato R,Yamamori S,Itakura M,Kodera Y,Nishizawa M,Sasaoka T,Onodera O,Yokoyama M
Fri Sep 02 00:00:00 UTC 2022
Importance of the Q/N-rich segment for protein stability of endogenous mouse TDP-43.
Scientific reports
Sato T,Oda K,Sakai S,Kato R,Yamamori S,Itakura M,Kodera Y,Nishizawa M,Sasaoka T,Onodera O,Yokoyama M
Fri Sep 02 00:00:00 UTC 2022
Therapeutic Effect of Rapamycin on TDP-43-Related Pathogenesis in Ischemic Stroke.
International journal of molecular sciences
Tsou YS,Lai JH,Chen KY,Chang CF,Huang CC
Fri Dec 30 00:00:00 UTC 2022
Parallel Appearance of Polyglutamine and Transactivation-Responsive DNA-Binding Protein 43 and Their Complementary Subcellular Localization in Brains of Patients With Spinocerebellar Ataxia Type 2.
Journal of neuropathology and experimental neurology
Koyano S,Yagishita S,Tada M,Doi H,Uchihara T,Tanaka F
Mon Jun 20 00:00:00 UTC 2022
Parallel Appearance of Polyglutamine and Transactivation-Responsive DNA-Binding Protein 43 and Their Complementary Subcellular Localization in Brains of Patients With Spinocerebellar Ataxia Type 2.
Journal of neuropathology and experimental neurology
Koyano S,Yagishita S,Tada M,Doi H,Uchihara T,Tanaka F
Mon Jun 20 00:00:00 UTC 2022
miR-23a suppression accelerates functional decline in the rNLS8 mouse model of TDP-43 proteinopathy.
Neurobiology of disease
Tsitkanou S,Della Gatta PA,Abbott G,Wallace MA,Lindsay A,Gerlinger-Romero F,Walker AK,Foletta VC,Russell AP
Sat Jan 01 00:00:00 UTC 2022
miR-23a suppression accelerates functional decline in the rNLS8 mouse model of TDP-43 proteinopathy.
Neurobiology of disease
Tsitkanou S,Della Gatta PA,Abbott G,Wallace MA,Lindsay A,Gerlinger-Romero F,Walker AK,Foletta VC,Russell AP
Sat Jan 01 00:00:00 UTC 2022
Feeder-supported in vitro exercise model using human satellite cells from patients with sporadic inclusion body myositis.
Scientific reports
Li Y,Chen W,Ogawa K,Koide M,Takahashi T,Hagiwara Y,Itoi E,Aizawa T,Tsuchiya M,Izumi R,Suzuki N,Aoki M,Kanzaki M
Thu Jan 20 00:00:00 UTC 2022
Plasma biomarkers for Alzheimer's Disease in relation to neuropathology and cognitive change.
Acta neuropathologica
Smirnov DS,Ashton NJ,Blennow K,Zetterberg H,Simrén J,Lantero-Rodriguez J,Karikari TK,Hiniker A,Rissman RA,Salmon DP,Galasko D
Fri Apr 01 00:00:00 UTC 2022
ATP-binding cassette transporter expression is widely dysregulated in frontotemporal dementia with TDP-43 inclusions.
Frontiers in molecular neuroscience
Katzeff JS,Lok HC,Bhatia S,Fu Y,Halliday GM,Kim WS
Fri Nov 18 00:00:00 UTC 2022
ATP-binding cassette transporter expression is widely dysregulated in frontotemporal dementia with TDP-43 inclusions.
Frontiers in molecular neuroscience
Katzeff JS,Lok HC,Bhatia S,Fu Y,Halliday GM,Kim WS
Fri Nov 18 00:00:00 UTC 2022
TDP-43 Oligomerization and Phase Separation Properties Are Necessary for Autoregulation.
Frontiers in neuroscience
Koehler LC,Grese ZR,Bastos ACS,Mamede LD,Heyduk T,Ayala YM
Sat Dec 10 00:00:00 UTC 2022
TDP-43 Pathology Exacerbates Cognitive Decline in Primary Age-Related Tauopathy.
Annals of neurology
Smirnov DS,Salmon DP,Galasko D,Edland SD,Pizzo DP,Goodwill V,Hiniker A
Thu Sep 01 00:00:00 UTC 2022
TARDBP Inhibits Porcine Epidemic Diarrhea Virus Replication through Degrading Viral Nucleocapsid Protein and Activating Type I Interferon Signaling.
Journal of virology
Dong S,Kong N,Zhang Y,Li Y,Sun D,Qin W,Zhai H,Zhai X,Yang X,Ye C,Ye M,Liu C,Yu L,Zheng H,Tong W,Yu H,Zhang W,Tong G,Shan T
Wed May 25 00:00:00 UTC 2022
TARDBP Inhibits Porcine Epidemic Diarrhea Virus Replication through Degrading Viral Nucleocapsid Protein and Activating Type I Interferon Signaling.
Journal of virology
Dong S,Kong N,Zhang Y,Li Y,Sun D,Qin W,Zhai H,Zhai X,Yang X,Ye C,Ye M,Liu C,Yu L,Zheng H,Tong W,Yu H,Zhang W,Tong G,Shan T
Wed May 25 00:00:00 UTC 2022
TARDBP Inhibits Porcine Epidemic Diarrhea Virus Replication through Degrading Viral Nucleocapsid Protein and Activating Type I Interferon Signaling.
Journal of virology
Dong S,Kong N,Zhang Y,Li Y,Sun D,Qin W,Zhai H,Zhai X,Yang X,Ye C,Ye M,Liu C,Yu L,Zheng H,Tong W,Yu H,Zhang W,Tong G,Shan T
Wed May 25 00:00:00 UTC 2022
TARDBP Inhibits Porcine Epidemic Diarrhea Virus Replication through Degrading Viral Nucleocapsid Protein and Activating Type I Interferon Signaling.
Journal of virology
Dong S,Kong N,Zhang Y,Li Y,Sun D,Qin W,Zhai H,Zhai X,Yang X,Ye C,Ye M,Liu C,Yu L,Zheng H,Tong W,Yu H,Zhang W,Tong G,Shan T
Wed May 25 00:00:00 UTC 2022
Unraveling the toxic effects mediated by the neurodegenerative disease-associated S375G mutation of TDP-43 and its S375E phosphomimetic variant.
The Journal of biological chemistry
Paron F,Barattucci S,Cappelli S,Romano M,Berlingieri C,Stuani C,Laurents D,Mompeán M,Buratti E
Mon Aug 01 00:00:00 UTC 2022
Unraveling the toxic effects mediated by the neurodegenerative disease-associated S375G mutation of TDP-43 and its S375E phosphomimetic variant.
The Journal of biological chemistry
Paron F,Barattucci S,Cappelli S,Romano M,Berlingieri C,Stuani C,Laurents D,Mompeán M,Buratti E
Mon Aug 01 00:00:00 UTC 2022
TDP-43 represses cryptic exon inclusion in the FTD-ALS gene UNC13A.
Nature
Ma XR,Prudencio M,Koike Y,Vatsavayai SC,Kim G,Harbinski F,Briner A,Rodriguez CM,Guo C,Akiyama T,Schmidt HB,Cummings BB,Wyatt DW,Kurylo K,Miller G,Mekhoubad S,Sallee N,Mekonnen G,Ganser L,Rubien JD,Jansen-West K,Cook CN,Pickles S,Oskarsson B,Graff-Radford NR,Boeve BF,Knopman DS,Petersen RC,Dickson DW,Shorter J,Myong S,Green EM,Seeley WW,Petrucelli L,Gitler AD
Tue Mar 01 00:00:00 UTC 2022
TDP-43 Pathology and Prionic Behavior in Human Cellular Models of Alzheimer's Disease Patients.
Biomedicines
Cuevas EP,Rodríguez-Fernández A,Palomo V,Martínez A,Martín-Requero Á
Sat Feb 05 00:00:00 UTC 2022
Sublethal enteroviral infection exacerbates disease progression in an ALS mouse model.
Journal of neuroinflammation
Xue YC,Liu H,Mohamud Y,Bahreyni A,Zhang J,Cashman NR,Luo H
Wed Jan 12 00:00:00 UTC 2022
Insulin-like growth factor 5 associates with human Aß plaques and promotes cognitive impairment.
Acta neuropathologica communications
Rauskolb S,Andreska T,Fries S,von Collenberg CR,Blum R,Monoranu CM,Villmann C,Sendtner M
Thu May 05 00:00:00 UTC 2022
Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins.
Science translational medicine
Gao J,Mewborne QT,Girdhar A,Sheth U,Coyne AN,Punathil R,Kang BG,Dasovich M,Veire A,DeJesus Hernandez M,Liu S,Shi Z,Dafinca R,Fouquerel E,Talbot K,Kam TI,Zhang YJ,Dickson D,Petrucelli L,van Blitterswijk M,Guo L,Dawson TM,Dawson VL,Leung AKL,Lloyd TE,Gendron TF,Rothstein JD,Zhang K
Wed Sep 14 00:00:00 UTC 2022
Therapeutic modulation of GSTO activity rescues FUS-associated neurotoxicity via deglutathionylation in ALS disease models.
Developmental cell
Cha SJ,Lee S,Choi HJ,Han YJ,Jeon YM,Jo M,Lee S,Nahm M,Lim SM,Kim SH,Kim HJ,Kim K
Mon Mar 28 00:00:00 UTC 2022
Loss of TDP-43 function and rimmed vacuoles persist after T cell depletion in a xenograft model of sporadic inclusion body myositis.
Science translational medicine
Britson KA,Ling JP,Braunstein KE,Montagne JM,Kastenschmidt JM,Wilson A,Ikenaga C,Tsao W,Pinal-Fernandez I,Russell KA,Reed N,Mozaffar T,Wagner KR,Ostrow LW,Corse AM,Mammen AL,Villalta SA,Larman HB,Wong PC,Lloyd TE
Wed Jan 19 00:00:00 UTC 2022
Loss of TDP-43 function and rimmed vacuoles persist after T cell depletion in a xenograft model of sporadic inclusion body myositis.
Science translational medicine
Britson KA,Ling JP,Braunstein KE,Montagne JM,Kastenschmidt JM,Wilson A,Ikenaga C,Tsao W,Pinal-Fernandez I,Russell KA,Reed N,Mozaffar T,Wagner KR,Ostrow LW,Corse AM,Mammen AL,Villalta SA,Larman HB,Wong PC,Lloyd TE
Wed Jan 19 00:00:00 UTC 2022
Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2.
Cell reports
Kim G,Nakayama L,Blum JA,Akiyama T,Boeynaems S,Chakraborty M,Couthouis J,Tassoni-Tsuchida E,Rodriguez CM,Bassik MC,Gitler AD
Tue Oct 25 00:00:00 UTC 2022
Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2.
Cell reports
Kim G,Nakayama L,Blum JA,Akiyama T,Boeynaems S,Chakraborty M,Couthouis J,Tassoni-Tsuchida E,Rodriguez CM,Bassik MC,Gitler AD
Tue Oct 25 00:00:00 UTC 2022
Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2.
Cell reports
Kim G,Nakayama L,Blum JA,Akiyama T,Boeynaems S,Chakraborty M,Couthouis J,Tassoni-Tsuchida E,Rodriguez CM,Bassik MC,Gitler AD
Tue Oct 25 00:00:00 UTC 2022
Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2.
Cell reports
Kim G,Nakayama L,Blum JA,Akiyama T,Boeynaems S,Chakraborty M,Couthouis J,Tassoni-Tsuchida E,Rodriguez CM,Bassik MC,Gitler AD
Tue Oct 25 00:00:00 UTC 2022
Ubiquitin-positive astrogliopathy clinically mimicking Parkinson's disease.
Acta neuropathologica communications
Morris M,Moghekar A,Guo H,Pletnikova O,Redding-Ochoa J,Albert M,Resnick SM,Chen L
Mon Nov 14 00:00:00 UTC 2022
Sigma-1 receptor agonist PRE-084 confers protection against TAR DNA-binding protein-43 toxicity through NRF2 signalling.
Redox biology
Lasbleiz C,Peyrel A,Tarot P,Sarniguet J,Crouzier L,Cubedo N,Delprat B,Rossel M,Maurice T,Liévens JC
Thu Dec 01 00:00:00 UTC 2022
Heterozygous frameshift variants in HNRNPA2B1 cause early-onset oculopharyngeal muscular dystrophy.
Nature communications
Kim HJ,Mohassel P,Donkervoort S,Guo L,O'Donovan K,Coughlin M,Lornage X,Foulds N,Hammans SR,Foley AR,Fare CM,Ford AF,Ogasawara M,Sato A,Iida A,Munot P,Ambegaonkar G,Phadke R,O'Donovan DG,Buchert R,Grimmel M,Töpf A,Zaharieva IT,Brady L,Hu Y,Lloyd TE,Klein A,Steinlin M,Kuster A,Mercier S,Marcorelles P,Péréon Y,Fleurence E,Manzur A,Ennis S,Upstill-Goddard R,Bello L,Bertolin C,Pegoraro E,Salviati L,French CE,Shatillo A,Raymond FL,Haack TB,Quijano-Roy S,Böhm J,Nelson I,Stojkovic T,Evangelista T,Straub V,Romero NB,Laporte J,Muntoni F,Nishino I,Tarnopolsky MA,Shorter J,Bönnemann CG,Taylor JP
Thu Apr 28 00:00:00 UTC 2022
DNA damage stress-induced translocation of mutant FUS proteins into cytosolic granules and screening for translocation inhibitors.
Frontiers in molecular neuroscience
Nogami M,Sano O,Adachi-Tominari K,Hayakawa-Yano Y,Furukawa T,Iwata H,Ogi K,Okano H,Yano M
Wed Jan 11 00:00:00 UTC 2023
DNA damage stress-induced translocation of mutant FUS proteins into cytosolic granules and screening for translocation inhibitors.
Frontiers in molecular neuroscience
Nogami M,Sano O,Adachi-Tominari K,Hayakawa-Yano Y,Furukawa T,Iwata H,Ogi K,Okano H,Yano M
Wed Jan 11 00:00:00 UTC 2023
Developmental deficits and staging of dynamics of age associated Alzheimer's disease neurodegeneration and neuronal loss in subjects with Down syndrome.
Acta neuropathologica communications
Wegiel J,Flory M,Kuchna I,Nowicki K,Wegiel J,Ma SY,Zhong N,Bobrowicz TW,de Leon M,Lai F,Silverman WP,Wisniewski T
Tue Jan 04 00:00:00 UTC 2022
An open source toolkit for repurposing Illumina sequencing systems as versatile fluidics and imaging platforms.
Scientific reports
Pandit K,Petrescu J,Cuevas M,Stephenson W,Smibert P,Phatnani H,Maniatis S
Thu Mar 24 00:00:00 UTC 2022
TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration.
Nature neuroscience
Xie M,Liu YU,Zhao S,Zhang L,Bosco DB,Pang YP,Zhong J,Sheth U,Martens YA,Zhao N,Liu CC,Zhuang Y,Wang L,Dickson DW,Mattson MP,Bu G,Wu LJ
Sat Jan 01 00:00:00 UTC 2022
TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration.
Nature neuroscience
Xie M,Liu YU,Zhao S,Zhang L,Bosco DB,Pang YP,Zhong J,Sheth U,Martens YA,Zhao N,Liu CC,Zhuang Y,Wang L,Dickson DW,Mattson MP,Bu G,Wu LJ
Sat Jan 01 00:00:00 UTC 2022
CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1.
The Journal of cell biology
Deng X,Sun X,Yue W,Duan Y,Hu R,Zhang K,Ni J,Cui J,Wang Q,Chen Y,Li A,Fang Y
Mon Jan 03 00:00:00 UTC 2022
Effects of intracellular calcium accumulation on proteins encoded by the major genes underlying amyotrophic lateral sclerosis.
Scientific reports
De Marco G,Lomartire A,Manera U,Canosa A,Grassano M,Casale F,Fuda G,Salamone P,Rinaudo MT,Colombatto S,Moglia C,Chiò A,Calvo A
Mon Jan 10 00:00:00 UTC 2022
NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility.
Nature communications
Gleixner AM,Verdone BM,Otte CG,Anderson EN,Ramesh N,Shapiro OR,Gale JR,Mauna JC,Mann JR,Copley KE,Daley EL,Ortega JA,Cicardi ME,Kiskinis E,Kofler J,Pandey UB,Trotti D,Donnelly CJ
Mon Jun 13 00:00:00 UTC 2022
NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility.
Nature communications
Gleixner AM,Verdone BM,Otte CG,Anderson EN,Ramesh N,Shapiro OR,Gale JR,Mauna JC,Mann JR,Copley KE,Daley EL,Ortega JA,Cicardi ME,Kiskinis E,Kofler J,Pandey UB,Trotti D,Donnelly CJ
Mon Jun 13 00:00:00 UTC 2022
NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility.
Nature communications
Gleixner AM,Verdone BM,Otte CG,Anderson EN,Ramesh N,Shapiro OR,Gale JR,Mauna JC,Mann JR,Copley KE,Daley EL,Ortega JA,Cicardi ME,Kiskinis E,Kofler J,Pandey UB,Trotti D,Donnelly CJ
Mon Jun 13 00:00:00 UTC 2022
TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A.
Nature
Brown AL,Wilkins OG,Keuss MJ,Hill SE,Zanovello M,Lee WC,Bampton A,Lee FCY,Masino L,Qi YA,Bryce-Smith S,Gatt A,Hallegger M,Fagegaltier D,Phatnani H,Newcombe J,Gustavsson EK,Seddighi S,Reyes JF,Coon SL,Ramos D,Schiavo G,Fisher EMC,Raj T,Secrier M,Lashley T,Ule J,Buratti E,Humphrey J,Ward ME,Fratta P
Tue Mar 01 00:00:00 UTC 2022
Entorhinal Subfield Vulnerability to Neurofibrillary Tangles in Aging and the Preclinical Stage of Alzheimer's Disease.
Journal of Alzheimer's disease : JAD
Llamas-Rodríguez J,Oltmer J,Greve DN,Williams E,Slepneva N,Wang R,Champion S,Lang-Orsini M,Fischl B,Frosch MP,van der Kouwe AJW,Augustinack JC
Wed Jun 08 00:00:00 UTC 2022
Analysis of the Biomarkers for Neurodegenerative Diseases in Aged Progranulin Deficient Mice.
International journal of molecular sciences
Zhao X,Hasan S,Liou B,Lin Y,Sun Y,Liu C
Thu Jan 06 00:00:00 UTC 2022
Analysis of the Biomarkers for Neurodegenerative Diseases in Aged Progranulin Deficient Mice.
International journal of molecular sciences
Zhao X,Hasan S,Liou B,Lin Y,Sun Y,Liu C
Thu Jan 06 00:00:00 UTC 2022
Association of Neurofibrillary Tangle Distribution With Age at Onset-Related Clinical Heterogeneity in Alzheimer Disease: An Autopsy Study.
Neurology
Smirnov DS,Salmon DP,Galasko D,Goodwill VS,Hansen LA,Zhao Y,Edland SD,Léger GC,Peavy GM,Jacobs DM,Rissman R,Pizzo DP,Hiniker A
Tue Feb 01 00:00:00 UTC 2022
Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export.
Cell reports
Duan L,Zaepfel BL,Aksenova V,Dasso M,Rothstein JD,Kalab P,Hayes LR
Tue Jul 19 00:00:00 UTC 2022
Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export.
Cell reports
Duan L,Zaepfel BL,Aksenova V,Dasso M,Rothstein JD,Kalab P,Hayes LR
Tue Jul 19 00:00:00 UTC 2022
Hyperphosphorylation-Mimetic TDP-43 Drives Amyloid Formation and Possesses Neuronal Toxicity at the Oligomeric Stage.
ACS chemical neuroscience
Chiang WC,Fang YS,Lye YS,Weng TY,Ganesan K,Huang SH,Chang LY,Chou SC,Chen YR
Wed Sep 07 00:00:00 UTC 2022
Long-standing multiple system atrophy-Parkinsonism with limbic and FTLD-type α-synuclein pathology.
Neuropathology and applied neurobiology
Coughlin DG,Dryden I,Goodwill VS,Pizzo DP,Wright B,Lessig S,Galasko D,MacKenzie IR,Hiniker A
Fri Apr 01 00:00:00 UTC 2022
Allele-specific silencing as therapy for familial amyotrophic lateral sclerosis caused by the p.G376D TARDBP mutation.
Brain communications
Romano R,De Luca M,Del Fiore VS,Pecoraro M,Lattante S,Sabatelli M,La Bella V,Bucci C
Thu Feb 09 00:00:00 UTC 2023
Allele-specific silencing as therapy for familial amyotrophic lateral sclerosis caused by the p.G376D TARDBP mutation.
Brain communications
Romano R,De Luca M,Del Fiore VS,Pecoraro M,Lattante S,Sabatelli M,La Bella V,Bucci C
Thu Feb 09 00:00:00 UTC 2023
Allele-specific silencing as therapy for familial amyotrophic lateral sclerosis caused by the p.G376D TARDBP mutation.
Brain communications
Romano R,De Luca M,Del Fiore VS,Pecoraro M,Lattante S,Sabatelli M,La Bella V,Bucci C
Thu Feb 09 00:00:00 UTC 2023
Allele-specific silencing as therapy for familial amyotrophic lateral sclerosis caused by the p.G376D TARDBP mutation.
Brain communications
Romano R,De Luca M,Del Fiore VS,Pecoraro M,Lattante S,Sabatelli M,La Bella V,Bucci C
Thu Feb 09 00:00:00 UTC 2023
Structure-Based Analysis of Protein Cluster Size for Super-Resolution Microscopy in the Nervous System.
Biomedicines
Wong CE,Chu YP,Tsai KJ
Thu Jan 27 00:00:00 UTC 2022
Robust Generation of Ready-to-Use Cryopreserved Motor Neurons from Human Pluripotent Stem Cells for Disease Modeling.
International journal of molecular sciences
Ting HC,Su HL,Chen MF,Harn HJ,Lin SZ,Chiou TW,Chang CY
Thu Nov 03 00:00:00 UTC 2022
Optineurin Deficiency and Insufficiency Lead to Higher Microglial TDP-43 Protein Levels.
International journal of molecular sciences
Prtenjaca N,Rob M,Alam MS,Markovinovic A,Stuani C,Buratti E,Munitic I
Sun Jun 19 00:00:00 UTC 2022
Optineurin Deficiency and Insufficiency Lead to Higher Microglial TDP-43 Protein Levels.
International journal of molecular sciences
Prtenjaca N,Rob M,Alam MS,Markovinovic A,Stuani C,Buratti E,Munitic I
Sun Jun 19 00:00:00 UTC 2022
ALS-linked KIF5A ΔExon27 mutant causes neuronal toxicity through gain-of-function.
EMBO reports
Pant DC,Parameswaran J,Rao L,Loss I,Chilukuri G,Parlato R,Shi L,Glass JD,Bassell GJ,Koch P,Yilmaz R,Weishaupt JH,Gennerich A,Jiang J
Wed Aug 03 00:00:00 UTC 2022
Testing of the therapeutic efficacy and safety of AMPA receptor RNA aptamers in an ALS mouse model.
Life science alliance
Akamatsu M,Yamashita T,Teramoto S,Huang Z,Lynch J,Toda T,Niu L,Kwak S
Fri Apr 01 00:00:00 UTC 2022
Testing of the therapeutic efficacy and safety of AMPA receptor RNA aptamers in an ALS mouse model.
Life science alliance
Akamatsu M,Yamashita T,Teramoto S,Huang Z,Lynch J,Toda T,Niu L,Kwak S
Fri Apr 01 00:00:00 UTC 2022
TDP43 promotes stemness of breast cancer stem cells through CD44 variant splicing isoforms.
Cell death & disease
Guo L,Ke H,Zhang H,Zou L,Yang Q,Lu X,Zhao L,Jiao B
Tue May 03 00:00:00 UTC 2022
TDP43 promotes stemness of breast cancer stem cells through CD44 variant splicing isoforms.
Cell death & disease
Guo L,Ke H,Zhang H,Zou L,Yang Q,Lu X,Zhao L,Jiao B
Tue May 03 00:00:00 UTC 2022
A postzygotic de novo NCDN mutation identified in a sporadic FTLD patient results in neurochondrin haploinsufficiency and altered FUS granule dynamics.
Acta neuropathologica communications
Nicolas G,Sévigny M,Lecoquierre F,Marguet F,Deschênes A,Del Pelaez MC,Feuillette S,Audebrand A,Lecourtois M,Rousseau S,Richard AC,Cassinari K,Deramecourt V,Duyckaerts C,Boland A,Deleuze JF,Meyer V,Clarimon Echavarria J,Gelpi E,Akiyama H,Hasegawa M,Kawakami I,Wong TH,Van Rooij JGJ,Van Swieten JC,Campion D,Dutchak PA,Wallon D,Lavoie-Cardinal F,Laquerrière A,Rovelet-Lecrux A,Sephton CF
Sat Feb 12 00:00:00 UTC 2022
Nuclear RNA transcript levels modulate nucleocytoplasmic distribution of ALS/FTD-associated protein FUS.
Scientific reports
Tsai YL,Mu YC,Manley JL
Tue May 17 00:00:00 UTC 2022
Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology.
Scientific reports
François-Moutal L,Scott DD,Ambrose AJ,Zerio CJ,Rodriguez-Sanchez M,Dissanayake K,May DG,Carlson JM,Barbieri E,Moutal A,Roux KJ,Shorter J,Khanna R,Barmada SJ,McGurk L,Khanna M
Tue May 17 00:00:00 UTC 2022
Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation.
The EMBO journal
Gruijs da Silva LA,Simonetti F,Hutten S,Riemenschneider H,Sternburg EL,Pietrek LM,Gebel J,Dötsch V,Edbauer D,Hummer G,Stelzl LS,Dormann D
Tue Apr 19 00:00:00 UTC 2022
Perception of Fragmented Letters by Patients With Pathologically Confirmed Dementia With Lewy Bodies or Alzheimer Disease.
Neurology
Salmon DP,Smirnov DS,Coughlin DG,Hamilton JM,Landy KM,Filoteo JV,Hiniker A,Hansen LA,Galasko D
Tue Nov 01 00:00:00 UTC 2022
Hyperosmotic-stress-induced liquid-liquid phase separation of ALS-related proteins in the nucleus.
Cell reports
Gao C,Gu J,Zhang H,Jiang K,Tang L,Liu R,Zhang L,Zhang P,Liu C,Dai B,Song J
Tue Jul 19 00:00:00 UTC 2022
Integrated stress response is involved in the 24(S)-hydroxycholesterol-induced unconventional cell death mechanism.
Cell death discovery
Urano Y,Osaki S,Chiba R,Noguchi N
Tue Oct 04 00:00:00 UTC 2022
Pathogenic Mutation of TDP-43 Impairs RNA Processing in a Cell Type-Specific Manner: Implications for the Pathogenesis of ALS/FTLD.
eNeuro
Imaizumi K,Ideno H,Sato T,Morimoto S,Okano H
Fri Jun 10 00:00:00 UTC 2022
Sequestration of TDP-43216-414 Aggregates by Cytoplasmic Expression of the proSAAS Chaperone.
ACS chemical neuroscience
Peinado JR,Chaplot K,Jarvela TS,Barbieri EM,Shorter J,Lindberg I
Wed Jun 01 00:00:00 UTC 2022
Physiological tissue-specific and age-related reduction of mouse TDP-43 levels is regulated by epigenetic modifications.
Disease models & mechanisms
Pacetti M,De Conti L,Marasco LE,Romano M,Rashid MM,Nubiè M,Baralle FE,Baralle M
Fri Apr 01 00:00:00 UTC 2022
ADARs act as potent regulators of circular transcriptome in cancer.
Nature communications
Shen H,An O,Ren X,Song Y,Tang SJ,Ke XY,Han J,Tay DJT,Ng VHE,Molias FB,Pitcheshwar P,Leong KW,Tan KK,Yang H,Chen L
Mon Mar 21 00:00:00 UTC 2022
Impaired disassembly of the axon initial segment restricts mitochondrial entry into damaged axons.
The EMBO journal
Kiryu-Seo S,Matsushita R,Tashiro Y,Yoshimura T,Iguchi Y,Katsuno M,Takahashi R,Kiyama H
Mon Oct 17 00:00:00 UTC 2022
Chemically induced senescence in human stem cell-derived neurons promotes phenotypic presentation of neurodegeneration.
Aging cell
Fathi A,Mathivanan S,Kong L,Petersen AJ,Harder CRK,Block J,Miller JM,Bhattacharyya A,Wang D,Zhang SC
Sat Jan 01 00:00:00 UTC 2022
TDP-43 regulates cholesterol biosynthesis by inhibiting sterol regulatory element-binding protein 2.
Scientific reports
Egawa N,Izumi Y,Suzuki H,Tsuge I,Fujita K,Shimano H,Izumikawa K,Takahashi N,Tsukita K,Enami T,Nakamura M,Watanabe A,Naitoh M,Suzuki S,Seki T,Kobayashi K,Toda T,Kaji R,Takahashi R,Inoue H
Sat May 14 00:00:00 UTC 2022
Stress induced TDP-43 mobility loss independent of stress granules.
Nature communications
Streit L,Kuhn T,Vomhof T,Bopp V,Ludolph AC,Weishaupt JH,Gebhardt JCM,Michaelis J,Danzer KM
Mon Sep 19 00:00:00 UTC 2022
Stress induced TDP-43 mobility loss independent of stress granules.
Nature communications
Streit L,Kuhn T,Vomhof T,Bopp V,Ludolph AC,Weishaupt JH,Gebhardt JCM,Michaelis J,Danzer KM
Mon Sep 19 00:00:00 UTC 2022
Prolyl Isomerase Pin1 Expression in the Spinal Motor Neurons of Patients With Sporadic Amyotrophic Lateral Sclerosis.
Journal of clinical neurology (Seoul, Korea)
Kato H,Naito M,Saito T,Hideyama T,Suzuki Y,Kimura T,Kwak S,Aizawa H
Fri Jul 01 00:00:00 UTC 2022
Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43.
Nature communications
Garcia Morato J,Hans F,von Zweydorf F,Feederle R,Elsässer SJ,Skodras AA,Gloeckner CJ,Buratti E,Neumann M,Kahle PJ
Wed Mar 09 00:00:00 UTC 2022
Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43.
Nature communications
Garcia Morato J,Hans F,von Zweydorf F,Feederle R,Elsässer SJ,Skodras AA,Gloeckner CJ,Buratti E,Neumann M,Kahle PJ
Wed Mar 09 00:00:00 UTC 2022
Intracellular energy controls dynamics of stress-induced ribonucleoprotein granules.
Nature communications
Wang T,Tian X,Kim HB,Jang Y,Huang Z,Na CH,Wang J
Fri Sep 23 00:00:00 UTC 2022
Understanding In Vitro Pathways to Drug Discovery for TDP-43 Proteinopathies.
International journal of molecular sciences
Cheng HWA,Callis TB,Montgomery AP,Danon JJ,Jorgensen WT,Ke YD,Ittner LM,Werry EL,Kassiou M
Fri Nov 25 00:00:00 UTC 2022
Understanding In Vitro Pathways to Drug Discovery for TDP-43 Proteinopathies.
International journal of molecular sciences
Cheng HWA,Callis TB,Montgomery AP,Danon JJ,Jorgensen WT,Ke YD,Ittner LM,Werry EL,Kassiou M
Fri Nov 25 00:00:00 UTC 2022
RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control.
Cellular and molecular life sciences : CMLS
Mohan HM,Trzeciakiewicz H,Pithadia A,Crowley EV,Pacitto R,Safren N,Trotter B,Zhang C,Zhou X,Zhang Y,Basrur V,Paulson HL,Sharkey LM
Sat Mar 05 00:00:00 UTC 2022
Characterizing Lewy Pathology in 231 Essential Tremor Brains From the Essential Tremor Centralized Brain Repository.
Journal of neuropathology and experimental neurology
Louis ED,Iglesias-Hernandez D,Hernandez NC,Flowers X,Kuo SH,Vonsattel JPG,Faust PL
Mon Sep 19 00:00:00 UTC 2022
A quantitative biology approach correlates neuronal toxicity with the largest inclusions of TDP-43.
Science advances
Cascella R,Bigi A,Riffert DG,Gagliani MC,Ermini E,Moretti M,Cortese K,Cecchi C,Chiti F
Fri Jul 29 00:00:00 UTC 2022
Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases.
Cell
Chang A,Xiang X,Wang J,Lee C,Arakhamia T,Simjanoska M,Wang C,Carlomagno Y,Zhang G,Dhingra S,Thierry M,Perneel J,Heeman B,Forgrave LM,DeTure M,DeMarco ML,Cook CN,Rademakers R,Dickson DW,Petrucelli L,Stowell MHB,Mackenzie IRA,Fitzpatrick AWP
Thu Apr 14 00:00:00 UTC 2022
Pathological 25 kDa C-Terminal Fragments of TDP-43 Are Present in Lymphoblastoid Cell Lines and Extracellular Vesicles from Patients Affected by Frontotemporal Lobar Degeneration and Neuronal Ceroidolipofuscinosis Carrying a GRN Mutation.
International journal of molecular sciences
Cimini S,Bellini S,Saraceno C,Benussi L,Ghidoni R,Giliani SC,Puoti G,Canafoglia L,Giaccone G,Rossi G
Wed Nov 09 00:00:00 UTC 2022
Nuclear pore destruction and loss of nuclear TDP-43 in FUS mutation-related amyotrophic lateral sclerosis motor neurons.
Journal of the neurological sciences
Aizawa H,Teramoto S,Hideyama T,Kato H,Terashi H,Suzuki Y,Kimura T,Kwak S
Sun May 15 00:00:00 UTC 2022
C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2α.
Theranostics
Zheng W,Wang K,Wu Y,Yan G,Zhang C,Li Z,Wang L,Chen S
Thu Dec 08 00:00:00 UTC 2022
TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury.
Nature neuroscience
Zambusi A,Novoselc KT,Hutten S,Kalpazidou S,Koupourtidou C,Schieweck R,Aschenbroich S,Silva L,Yazgili AS,van Bebber F,Schmid B,Möller G,Tritscher C,Stigloher C,Delbridge C,Sirko S,Günes ZI,Liebscher S,Schlegel J,Aliee H,Theis F,Meiners S,Kiebler M,Dormann D,Ninkovic J
Thu Dec 01 00:00:00 UTC 2022
TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury.
Nature neuroscience
Zambusi A,Novoselc KT,Hutten S,Kalpazidou S,Koupourtidou C,Schieweck R,Aschenbroich S,Silva L,Yazgili AS,van Bebber F,Schmid B,Möller G,Tritscher C,Stigloher C,Delbridge C,Sirko S,Günes ZI,Liebscher S,Schlegel J,Aliee H,Theis F,Meiners S,Kiebler M,Dormann D,Ninkovic J
Thu Dec 01 00:00:00 UTC 2022
TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury.
Nature neuroscience
Zambusi A,Novoselc KT,Hutten S,Kalpazidou S,Koupourtidou C,Schieweck R,Aschenbroich S,Silva L,Yazgili AS,van Bebber F,Schmid B,Möller G,Tritscher C,Stigloher C,Delbridge C,Sirko S,Günes ZI,Liebscher S,Schlegel J,Aliee H,Theis F,Meiners S,Kiebler M,Dormann D,Ninkovic J
Thu Dec 01 00:00:00 UTC 2022
TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury.
Nature neuroscience
Zambusi A,Novoselc KT,Hutten S,Kalpazidou S,Koupourtidou C,Schieweck R,Aschenbroich S,Silva L,Yazgili AS,van Bebber F,Schmid B,Möller G,Tritscher C,Stigloher C,Delbridge C,Sirko S,Günes ZI,Liebscher S,Schlegel J,Aliee H,Theis F,Meiners S,Kiebler M,Dormann D,Ninkovic J
Thu Dec 01 00:00:00 UTC 2022
Accumulation of Nonfibrillar TDP-43 in the Rough Endoplasmic Reticulum Is the Early-Stage Pathology in Amyotrophic Lateral Sclerosis.
Journal of neuropathology and experimental neurology
Kon T,Mori F,Tanji K,Miki Y,Nishijima H,Nakamura T,Kinoshita I,Suzuki C,Kurotaki H,Tomiyama M,Wakabayashi K
Tue Mar 29 00:00:00 UTC 2022
Diverse limbic comorbidities cause limbic and temporal atrophy in lewy body disease.
Parkinsonism & related disorders
Sakurai K,Kaneda D,Morimoto S,Uchida Y,Inui S,Kimura Y,Cai C,Kato T,Ito K,Hashizume Y
Thu Dec 01 00:00:00 UTC 2022
A motor neuron disease mouse model reveals a non-canonical profile of senescence biomarkers.
Disease models & mechanisms
Torres P,Anerillas C,Ramírez-Núñez O,Fernàndez A,Encinas M,Povedano M,Andrés-Benito P,Ferrer I,Ayala V,Pamplona R,Portero-Otín M
Mon Aug 01 00:00:00 UTC 2022
Vulnerable exons, like ACADM exon 5, are highly dependent on maintaining a correct balance between splicing enhancers and silencers.
Human mutation
Holm LL,Doktor TK,Hansen MB,Petersen USS,Andresen BS
Tue Feb 01 00:00:00 UTC 2022
UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates behavioral defects in the C9ORF72 animal model.
Neuron
Zhang K,Wang A,Zhong K,Qi S,Wei C,Shu X,Tu WY,Xu W,Xia C,Xiao Y,Chen A,Bai L,Zhang J,Luo B,Wang W,Shen C
Wed Jun 16 00:00:00 UTC 2021
The FUS gene is dual-coding with both proteins contributing to FUS-mediated toxicity.
EMBO reports
Brunet MA,Jacques JF,Nassari S,Tyzack GE,McGoldrick P,Zinman L,Jean S,Robertson J,Patani R,Roucou X
Thu Jan 07 00:00:00 UTC 2021
TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination.
The Journal of cell biology
Ho WY,Chang JC,Lim K,Cazenave-Gassiot A,Nguyen AT,Foo JC,Muralidharan S,Viera-Ortiz A,Ong SJM,Hor JH,Agrawal I,Hoon S,Arogundade OA,Rodriguez MJ,Lim SM,Kim SH,Ravits J,Ng SY,Wenk MR,Lee EB,Tucker-Kellogg G,Ling SC
Mon Sep 06 00:00:00 UTC 2021
Clinicopathological Staging of Dynamics of Neurodegeneration and Neuronal Loss in Alzheimer Disease.
Journal of neuropathology and experimental neurology
Wegiel J,Flory M,Kuchna I,Nowicki K,Ma SY,Wegiel J,Badmaev E,Leon M,Wisniewski T,Reisberg B
Fri Jan 01 00:00:00 UTC 2021
Impact of a frequent nearsplice SOD1 variant in amyotrophic lateral sclerosis: optimising SOD1 genetic screening for gene therapy opportunities.
Journal of neurology, neurosurgery, and psychiatry
Muratet F,Teyssou E,Chiot A,Boillée S,Lobsiger CS,Bohl D,Gyorgy B,Guegan J,Marie Y,Amador MDM,Salachas F,Meininger V,Bernard E,Antoine JC,Camdessanché JP,Camu W,Cazeneuve C,Fauret-Amsellem AL,Leguern E,Mouzat K,Guissart C,Lumbroso S,Corcia P,Vourc'h P,Grapperon AM,Attarian S,Verschueren A,Seilhean D,Millecamps S
Wed Sep 01 00:00:00 UTC 2021
TMEM106B modifies TDP-43 pathology in human ALS brain and cell-based models of TDP-43 proteinopathy.
Acta neuropathologica
Mao F,Robinson JL,Unger T,Posavi M,Amado DA,Elman L,Grossman M,Wolk DA,Lee EB,Van Deerlin VM,Porta S,Lee VMY,Trojanowski JQ,Chen-Plotkin AS
Fri Oct 01 00:00:00 UTC 2021
Staufen1 in Human Neurodegeneration.
Annals of neurology
Paul S,Dansithong W,Figueroa KP,Gandelman M,Scoles DR,Pulst SM
Tue Jun 01 00:00:00 UTC 2021
Circ-Hdgfrp3 shuttles along neurites and is trapped in aggregates formed by ALS-associated mutant FUS.
iScience
D'Ambra E,Santini T,Vitiello E,D'Uva S,Silenzi V,Morlando M,Bozzoni I
Fri Dec 17 00:00:00 UTC 2021
Neuronal VPS35 deletion induces spinal cord motor neuron degeneration and early post-natal lethality.
Brain communications
Sargent D,Cunningham LA,Dues DJ,Ma Y,Kordich JJ,Mercado G,Brundin P,Cowell RM,Moore DJ
Tue Dec 14 00:00:00 UTC 2021
Characterization of the upstream and intron promoters of the gene encoding TAR DNA-binding protein.
Scientific reports
Hasegawa-Ogawa M,Okano HJ
Thu Apr 22 00:00:00 UTC 2021
Characterization of the upstream and intron promoters of the gene encoding TAR DNA-binding protein.
Scientific reports
Hasegawa-Ogawa M,Okano HJ
Thu Apr 22 00:00:00 UTC 2021
Mislocalisation of TDP-43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex.
Journal of neurochemistry
Dyer MS,Reale LA,Lewis KE,Walker AK,Dickson TC,Woodhouse A,Blizzard CA
Sat May 01 00:00:00 UTC 2021
Mislocalisation of TDP-43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex.
Journal of neurochemistry
Dyer MS,Reale LA,Lewis KE,Walker AK,Dickson TC,Woodhouse A,Blizzard CA
Sat May 01 00:00:00 UTC 2021
Effects of TDP-43 overexpression on neuron proteome and morphology in vitro.
Molecular and cellular neurosciences
Atkinson RAK,Fair HL,Wilson R,Vickers JC,King AE
Thu Jul 01 00:00:00 UTC 2021
Effects of TDP-43 overexpression on neuron proteome and morphology in vitro.
Molecular and cellular neurosciences
Atkinson RAK,Fair HL,Wilson R,Vickers JC,King AE
Thu Jul 01 00:00:00 UTC 2021
Behavioral Deficits in Mice with Postnatal Disruption of Ndel1 in Forebrain Excitatory Neurons: Implications for Epilepsy and Neuropsychiatric Disorders.
Cerebral cortex communications
Gavrilovici C,Jiang Y,Kiroski I,Sterley TL,Vandal M,Bains J,Park SK,Rho JM,Teskey GC,Nguyen MD
Tue Feb 23 00:00:00 UTC 2021
FUS/TLS Suppresses Enterovirus Replication and Promotes Antiviral Innate Immune Responses.
Journal of virology
Xue YC,Ng CS,Mohamud Y,Fung G,Liu H,Bahreyni A,Zhang J,Luo H
Mon May 24 00:00:00 UTC 2021
TDP-43 condensation properties specify its RNA-binding and regulatory repertoire.
Cell
Hallegger M,Chakrabarti AM,Lee FCY,Lee BL,Amalietti AG,Odeh HM,Copley KE,Rubien JD,Portz B,Kuret K,Huppertz I,Rau F,Patani R,Fawzi NL,Shorter J,Luscombe NM,Ule J
Thu Sep 02 00:00:00 UTC 2021
Phosphorylation regulates arginine-rich RNA-binding protein solubility and oligomerization.
The Journal of biological chemistry
Kundinger SR,Dammer EB,Yin L,Hurst C,Shapley S,Ping L,Khoshnevis S,Ghalei H,Duong DM,Seyfried NT
Mon Nov 01 00:00:00 UTC 2021
Pathological manifestation of human endogenous retrovirus K in frontotemporal dementia.
Communications medicine
Phan K,He Y,Fu Y,Dzamko N,Bhatia S,Gold J,Rowe D,Ke YD,Ittner LM,Hodges JR,Piguet O,Kiernan MC,Halliday GM,Kim WS
Tue Aug 01 00:00:00 UTC 2023
Multiple system aging-related tau astrogliopathy with complex proteinopathy in an oligosymptomatic octogenarian.
Neuropathology : official journal of the Japanese Society of Neuropathology
Klotz S,Fischer P,Hinterberger M,Ricken G,Hönigschnabl S,Gelpi E,Kovacs GG
Mon Feb 01 00:00:00 UTC 2021
Establishment of chemically oligomerizable TAR DNA-binding protein-43 which mimics amyotrophic lateral sclerosis pathology in mammalian cells.
Laboratory investigation; a journal of technical methods and pathology
Yamanaka Y,Miyagi T,Harada Y,Kuroda M,Kanekura K
Fri Oct 01 00:00:00 UTC 2021
Targeting TDP-43 Pathology Alleviates Cognitive and Motor Deficits Caused by Chronic Cerebral Hypoperfusion.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Thammisetty SS,Renaud L,Picher-Martel V,Weng YC,Calon F,Saikali S,Julien JP,Kriz J
Thu Apr 01 00:00:00 UTC 2021
Targeting TDP-43 Pathology Alleviates Cognitive and Motor Deficits Caused by Chronic Cerebral Hypoperfusion.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Thammisetty SS,Renaud L,Picher-Martel V,Weng YC,Calon F,Saikali S,Julien JP,Kriz J
Thu Apr 01 00:00:00 UTC 2021
Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.
Neuron
Dewan R,Chia R,Ding J,Hickman RA,Stein TD,Abramzon Y,Ahmed S,Sabir MS,Portley MK,Tucci A,Ibáñez K,Shankaracharya FNU,Keagle P,Rossi G,Caroppo P,Tagliavini F,Waldo ML,Johansson PM,Nilsson CF,Rowe JB,Benussi L,Binetti G,Ghidoni R,Jabbari E,Viollet C,Glass JD,Singleton AB,Silani V,Ross OA,Ryten M,Torkamani A,Tanaka T,Ferrucci L,Resnick SM,Pickering-Brown S,Brady CB,Kowal N,Hardy JA,Van Deerlin V,Vonsattel JP,Harms MB,Morris HR,Ferrari R,Landers JE,Chiò A,Gibbs JR,Dalgard CL,Scholz SW,Traynor BJ
Wed Feb 03 00:00:00 UTC 2021
hnRNP A1B, a Splice Variant of HNRNPA1, Is Spatially and Temporally Regulated.
Frontiers in neuroscience
Gagné M,Deshaies JE,Sidibé H,Benchaar Y,Arbour D,Dubinski A,Litt G,Peyrard S,Robitaille R,Sephton CF,Vande Velde C
Tue Oct 12 00:00:00 UTC 2021
Amyloid β and tau pathology in brains of aged pinniped species (sea lion, seal, and walrus).
Acta neuropathologica communications
Takaichi Y,Chambers JK,Takahashi K,Soeda Y,Koike R,Katsumata E,Kita C,Matsuda F,Haritani M,Takashima A,Nakayama H,Uchida K
Thu Jan 07 00:00:00 UTC 2021
Expression of C9orf72 hexanucleotide repeat expansion leads to formation of RNA foci and dipeptide repeat proteins but does not influence autophagy or proteasomal function in neuronal cells.
Biochimica et biophysica acta. Molecular cell research
Leskelä S,Huber N,Hoffmann D,Rostalski H,Remes AM,Takalo M,Hiltunen M,Haapasalo A
Tue Jun 01 00:00:00 UTC 2021
CellFIE: CRISPR- and Cell Fusion-based Two-hybrid Interaction Mapping of Endogenous Proteins.
Journal of molecular biology
Secker C,Kostova S,Niederlechner H,Beetz S,Wendland I,Liebich MJ,Polzer O,Groh M,Schnoegl S,Trepte P,Wanker EE
Fri Dec 03 00:00:00 UTC 2021
Fast Progression in Amyotrophic Lateral Sclerosis Is Associated With Greater TDP-43 Burden in Spinal Cord.
Journal of neuropathology and experimental neurology
Cathcart SJ,Appel SH,Peterson LE,Greene EP,Powell SZ,Arumanayagam AS,Rivera AL,Cykowski MD
Fri Sep 10 00:00:00 UTC 2021
Genetic screening of ANXA11 revealed novel mutations linked to amyotrophic lateral sclerosis.
Neurobiology of aging
Teyssou E,Muratet F,Amador MD,Ferrien M,Lautrette G,Machat S,Boillée S,Larmonier T,Saker S,Leguern E,Cazeneuve C,Marie Y,Guegan J,Gyorgy B,Cintas P,Meininger V,Le Forestier N,Salachas F,Couratier P,Camu W,Seilhean D,Millecamps S
Mon Mar 01 00:00:00 UTC 2021
Genetic screening of ANXA11 revealed novel mutations linked to amyotrophic lateral sclerosis.
Neurobiology of aging
Teyssou E,Muratet F,Amador MD,Ferrien M,Lautrette G,Machat S,Boillée S,Larmonier T,Saker S,Leguern E,Cazeneuve C,Marie Y,Guegan J,Gyorgy B,Cintas P,Meininger V,Le Forestier N,Salachas F,Couratier P,Camu W,Seilhean D,Millecamps S
Mon Mar 01 00:00:00 UTC 2021
Transmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate.
Acta neuropathologica communications
Lam S,Petit F,Hérard AS,Boluda S,Eddarkaoui S,Guillermier M,Buée L,Duyckaerts C,Haïk S,Picq JL,Dhenain M
Tue Oct 12 00:00:00 UTC 2021
Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral sclerosis.
European journal of medicinal chemistry
Rojas-Prats E,Martinez-Gonzalez L,Gonzalo-Consuegra C,Liachko NF,Perez C,Ramírez D,Kraemer BC,Martin-Requero Á,Perez DI,Gil C,de Lago E,Martinez A
Fri Jan 15 00:00:00 UTC 2021
Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral sclerosis.
European journal of medicinal chemistry
Rojas-Prats E,Martinez-Gonzalez L,Gonzalo-Consuegra C,Liachko NF,Perez C,Ramírez D,Kraemer BC,Martin-Requero Á,Perez DI,Gil C,de Lago E,Martinez A
Fri Jan 15 00:00:00 UTC 2021
Identification of Genetic Modifiers of TDP-43: Inflammatory Activation of Astrocytes for Neuroinflammation.
Cells
Kim JH,Rahman MH,Park D,Jo M,Kim HJ,Suk K
Thu Mar 18 00:00:00 UTC 2021
The E50K optineurin mutation impacts autophagy-mediated degradation of TDP-43 and leads to RGC apoptosis in vivo and in vitro.
Cell death discovery
Zhang S,Shao Z,Liu X,Hou M,Cheng F,Lei D,Yuan H
Mon Mar 15 00:00:00 UTC 2021
TDP-43 stabilizes G3BP1 mRNA: relevance to amyotrophic lateral sclerosis/frontotemporal dementia.
Brain : a journal of neurology
Sidibé H,Khalfallah Y,Xiao S,Gómez NB,Fakim H,Tank EMH,Di Tomasso G,Bareke E,Aulas A,McKeever PM,Melamed Z,Destroimaisons L,Deshaies JE,Zinman L,Parker JA,Legault P,Tétreault M,Barmada SJ,Robertson J,Vande Velde C
Thu Dec 16 00:00:00 UTC 2021
TDP-43 stabilizes G3BP1 mRNA: relevance to amyotrophic lateral sclerosis/frontotemporal dementia.
Brain : a journal of neurology
Sidibé H,Khalfallah Y,Xiao S,Gómez NB,Fakim H,Tank EMH,Di Tomasso G,Bareke E,Aulas A,McKeever PM,Melamed Z,Destroimaisons L,Deshaies JE,Zinman L,Parker JA,Legault P,Tétreault M,Barmada SJ,Robertson J,Vande Velde C
Thu Dec 16 00:00:00 UTC 2021
TDP-43 stabilizes G3BP1 mRNA: relevance to amyotrophic lateral sclerosis/frontotemporal dementia.
Brain : a journal of neurology
Sidibé H,Khalfallah Y,Xiao S,Gómez NB,Fakim H,Tank EMH,Di Tomasso G,Bareke E,Aulas A,McKeever PM,Melamed Z,Destroimaisons L,Deshaies JE,Zinman L,Parker JA,Legault P,Tétreault M,Barmada SJ,Robertson J,Vande Velde C
Thu Dec 16 00:00:00 UTC 2021
Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology.
eLife
Anderson EN,Morera AA,Kour S,Cherry JD,Ramesh N,Gleixner A,Schwartz JC,Ebmeier C,Old W,Donnelly CJ,Cheng JP,Kline AE,Kofler J,Stein TD,Pandey UB
Wed May 26 00:00:00 UTC 2021
Repetitive Traumatic Brain Injury Is Associated With TDP-43 Alterations, Neurodegeneration, and Glial Activation in Mice.
Journal of neuropathology and experimental neurology
Rajič Bumber J,Pilipović K,Janković T,Dolenec P,Gržeta N,Križ J,Župan G
Fri Jan 01 00:00:00 UTC 2021
Optineurin defects cause TDP43-pathology with autophagic vacuolar formation.
Neurobiology of disease
Kurashige T,Kuramochi M,Ohsawa R,Yamashita Y,Shioi G,Morino H,Kamada M,Ayaki T,Ito H,Sotomaru Y,Maruyama H,Kawakami H
Fri Jan 01 00:00:00 UTC 2021
MATR3 F115C knock-in mice do not exhibit motor defects or neuropathological features of ALS.
Biochemical and biophysical research communications
van Bruggen R,Maksimovic K,You J,Tran DD,Lee HJ,Khan M,Kao CS,Kim JR,Cho W,Chen XXL,Park J
Fri Sep 03 00:00:00 UTC 2021
Therapeutic potential of novel Cell Division Cycle Kinase 7 inhibitors on TDP-43-related pathogenesis such as Frontotemporal Lobar Degeneration (FTLD) and amyotrophic lateral sclerosis (ALS).
Journal of neurochemistry
Vaca G,Martinez-Gonzalez L,Fernandez A,Rojas-Prats E,Porras G,Cuevas EP,Gil C,Martinez A,Martin-Requero Á
Mon Feb 01 00:00:00 UTC 2021
Therapeutic potential of novel Cell Division Cycle Kinase 7 inhibitors on TDP-43-related pathogenesis such as Frontotemporal Lobar Degeneration (FTLD) and amyotrophic lateral sclerosis (ALS).
Journal of neurochemistry
Vaca G,Martinez-Gonzalez L,Fernandez A,Rojas-Prats E,Porras G,Cuevas EP,Gil C,Martinez A,Martin-Requero Á
Mon Feb 01 00:00:00 UTC 2021
Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature.
Acta neuropathologica communications
Kahriman A,Bouley J,Smith TW,Bosco DA,Woerman AL,Henninger N
Tue Jun 29 00:00:00 UTC 2021
Pontine Arteriolosclerosis and Locus Coeruleus Oxidative Stress Differentiate Resilience from Mild Cognitive Impairment in a Clinical Pathologic Cohort.
Journal of neuropathology and experimental neurology
Kelly SC,Nelson PT,Counts SE
Mon Mar 22 00:00:00 UTC 2021
PCBP2 Is Downregulated in Degenerating Neurons and Rarely Observed in TDP-43-Positive Inclusions in Sporadic Amyotrophic Lateral Sclerosis.
Journal of neuropathology and experimental neurology
Yoshimura M,Honda H,Sasagasako N,Mori S,Hamasaki H,Suzuki SO,Ishii T,Ninomiya T,Kira JI,Iwaki T
Mon Feb 22 00:00:00 UTC 2021
TDP-43 prevents endogenous RNAs from triggering a lethal RIG-I-dependent interferon response.
Cell reports
Dunker W,Ye X,Zhao Y,Liu L,Richardson A,Karijolich J
Tue Apr 13 00:00:00 UTC 2021
TDP-43 prevents endogenous RNAs from triggering a lethal RIG-I-dependent interferon response.
Cell reports
Dunker W,Ye X,Zhao Y,Liu L,Richardson A,Karijolich J
Tue Apr 13 00:00:00 UTC 2021
Defective cyclophilin A induces TDP-43 proteinopathy: implications for amyotrophic lateral sclerosis and frontotemporal dementia.
Brain : a journal of neurology
Pasetto L,Grassano M,Pozzi S,Luotti S,Sammali E,Migazzi A,Basso M,Spagnolli G,Biasini E,Micotti E,Cerovic M,Carli M,Forloni G,De Marco G,Manera U,Moglia C,Mora G,Traynor BJ,Chiò A,Calvo A,Bonetto V
Fri Dec 31 00:00:00 UTC 2021
Defective cyclophilin A induces TDP-43 proteinopathy: implications for amyotrophic lateral sclerosis and frontotemporal dementia.
Brain : a journal of neurology
Pasetto L,Grassano M,Pozzi S,Luotti S,Sammali E,Migazzi A,Basso M,Spagnolli G,Biasini E,Micotti E,Cerovic M,Carli M,Forloni G,De Marco G,Manera U,Moglia C,Mora G,Traynor BJ,Chiò A,Calvo A,Bonetto V
Fri Dec 31 00:00:00 UTC 2021
Defective cyclophilin A induces TDP-43 proteinopathy: implications for amyotrophic lateral sclerosis and frontotemporal dementia.
Brain : a journal of neurology
Pasetto L,Grassano M,Pozzi S,Luotti S,Sammali E,Migazzi A,Basso M,Spagnolli G,Biasini E,Micotti E,Cerovic M,Carli M,Forloni G,De Marco G,Manera U,Moglia C,Mora G,Traynor BJ,Chiò A,Calvo A,Bonetto V
Fri Dec 31 00:00:00 UTC 2021
Defective cyclophilin A induces TDP-43 proteinopathy: implications for amyotrophic lateral sclerosis and frontotemporal dementia.
Brain : a journal of neurology
Pasetto L,Grassano M,Pozzi S,Luotti S,Sammali E,Migazzi A,Basso M,Spagnolli G,Biasini E,Micotti E,Cerovic M,Carli M,Forloni G,De Marco G,Manera U,Moglia C,Mora G,Traynor BJ,Chiò A,Calvo A,Bonetto V
Fri Dec 31 00:00:00 UTC 2021
Defective cyclophilin A induces TDP-43 proteinopathy: implications for amyotrophic lateral sclerosis and frontotemporal dementia.
Brain : a journal of neurology
Pasetto L,Grassano M,Pozzi S,Luotti S,Sammali E,Migazzi A,Basso M,Spagnolli G,Biasini E,Micotti E,Cerovic M,Carli M,Forloni G,De Marco G,Manera U,Moglia C,Mora G,Traynor BJ,Chiò A,Calvo A,Bonetto V
Fri Dec 31 00:00:00 UTC 2021
Defective cyclophilin A induces TDP-43 proteinopathy: implications for amyotrophic lateral sclerosis and frontotemporal dementia.
Brain : a journal of neurology
Pasetto L,Grassano M,Pozzi S,Luotti S,Sammali E,Migazzi A,Basso M,Spagnolli G,Biasini E,Micotti E,Cerovic M,Carli M,Forloni G,De Marco G,Manera U,Moglia C,Mora G,Traynor BJ,Chiò A,Calvo A,Bonetto V
Fri Dec 31 00:00:00 UTC 2021
Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis.
Molecular neurodegeneration
Pasetto L,Callegaro S,Corbelli A,Fiordaliso F,Ferrara D,Brunelli L,Sestito G,Pastorelli R,Bianchi E,Cretich M,Chiari M,Potrich C,Moglia C,Corbo M,Sorarù G,Lunetta C,Calvo A,Chiò A,Mora G,Pennuto M,Quattrone A,Rinaldi F,D'Agostino VG,Basso M,Bonetto V
Tue Aug 10 00:00:00 UTC 2021
NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis.
Cell metabolism
Park MK,Zhang L,Min KW,Cho JH,Yeh CC,Moon H,Hormaechea-Agulla D,Mun H,Ko S,Lee JW,Jathar S,Smith AS,Yao Y,Giang NT,Vu HH,Yan VC,Bridges MC,Kourtidis A,Muller F,Chang JH,Song SJ,Nakagawa S,Hirose T,Yoon JH,Song MS
Tue Dec 07 00:00:00 UTC 2021
TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS.
Nature structural & molecular biology
Zuo X,Zhou J,Li Y,Wu K,Chen Z,Luo Z,Zhang X,Liang Y,Esteban MA,Zhou Y,Fu XD
Mon Feb 01 00:00:00 UTC 2021
TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS.
Nature structural & molecular biology
Zuo X,Zhou J,Li Y,Wu K,Chen Z,Luo Z,Zhang X,Liang Y,Esteban MA,Zhou Y,Fu XD
Mon Feb 01 00:00:00 UTC 2021
Hippocampal Sclerosis in Frontotemporal Dementia: When Vascular Pathology Meets Neurodegeneration.
Journal of neuropathology and experimental neurology
Sieben A,Van Langenhove T,Vermeiren Y,Gossye H,Praet M,Vanhauwaert D,Cousaert C,Engelborghs S,Raedt R,Boon P,Santens P,De Deyn PP,Bracke KR,De Meulemeester K,Van Broeckhoven C,Martin JJ,Bjerke M
Mon Mar 22 00:00:00 UTC 2021
Riluzole does not ameliorate disease caused by cytoplasmic TDP-43 in a mouse model of amyotrophic lateral sclerosis.
The European journal of neuroscience
Wright AL,Della Gatta PA,Le S,Berning BA,Mehta P,Jacobs KR,Gul H,San Gil R,Hedl TJ,Riddell WR,Watson O,Keating SS,Venturato J,Chung RS,Atkin JD,Lee A,Shi B,Blizzard CA,Morsch M,Walker AK
Wed Sep 01 00:00:00 UTC 2021
Identification of hub molecules of FUS-ALS by Bayesian gene regulatory network analysis of iPSC model: iBRN.
Neurobiology of disease
Nogami M,Ishikawa M,Doi A,Sano O,Sone T,Akiyama T,Aoki M,Nakanishi A,Ogi K,Yano M,Okano H
Thu Jul 01 00:00:00 UTC 2021
Identification of hub molecules of FUS-ALS by Bayesian gene regulatory network analysis of iPSC model: iBRN.
Neurobiology of disease
Nogami M,Ishikawa M,Doi A,Sano O,Sone T,Akiyama T,Aoki M,Nakanishi A,Ogi K,Yano M,Okano H
Thu Jul 01 00:00:00 UTC 2021
Patterns of neuronal Rhes as a novel hallmark of tauopathies.
Acta neuropathologica
Ehrenberg AJ,Leng K,Letourneau KN,Hernandez I,Lew C,Seeley WW,Spina S,Miller B,Heinsen H,Kampmann M,Kosik KS,Grinberg LT
Sat May 01 00:00:00 UTC 2021
Neuropathological and behavioral characterization of aged Grn R493X progranulin-deficient frontotemporal dementia knockin mice.
Acta neuropathologica communications
Frew J,Nygaard HB
Thu Apr 01 00:00:00 UTC 2021
Neuropathological and behavioral characterization of aged Grn R493X progranulin-deficient frontotemporal dementia knockin mice.
Acta neuropathologica communications
Frew J,Nygaard HB
Thu Apr 01 00:00:00 UTC 2021
CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases.
Disease models & mechanisms
Wall JM,Basu A,Zunica ERM,Dubuisson OS,Pergola K,Broussard JP,Kirwan JP,Axelrod CL,Johnson AE
Thu Jul 01 00:00:00 UTC 2021
CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases.
Disease models & mechanisms
Wall JM,Basu A,Zunica ERM,Dubuisson OS,Pergola K,Broussard JP,Kirwan JP,Axelrod CL,Johnson AE
Thu Jul 01 00:00:00 UTC 2021
Deferoxamine mesylate improves splicing and GAA activity of the common c.-32-13T>G allele in late-onset PD patient fibroblasts.
Molecular therapy. Methods & clinical development
Buratti E,Peruzzo P,Braga L,Zanin I,Stuani C,Goina E,Romano M,Giacca M,Dardis A
Fri Mar 12 00:00:00 UTC 2021
Tau-tubulin kinase 1 phosphorylates TDP-43 at disease-relevant sites and exacerbates TDP-43 pathology.
Neurobiology of disease
Tian Y,Wang Y,Jablonski AM,Hu Y,Sugam JA,Koglin M,Stachel SJ,Zhou H,Uslaner JM,Parmentier-Batteur S
Wed Dec 01 00:00:00 UTC 2021
Tau-tubulin kinase 1 phosphorylates TDP-43 at disease-relevant sites and exacerbates TDP-43 pathology.
Neurobiology of disease
Tian Y,Wang Y,Jablonski AM,Hu Y,Sugam JA,Koglin M,Stachel SJ,Zhou H,Uslaner JM,Parmentier-Batteur S
Wed Dec 01 00:00:00 UTC 2021
Mid to late-life scores of depression in the cognitively healthy are associated with cognitive status and Alzheimer's disease pathology at death.
International journal of geriatric psychiatry
Robinson AC,Roncaroli F,Davidson YS,Minshull J,Heal C,Montaldi D,Payton A,Horan MA,Pendleton N,Mann DMA
Sat May 01 00:00:00 UTC 2021
Haploinsufficiency of the TDP43 ubiquitin E3 ligase RNF220 leads to ALS-like motor neuron defects in the mouse.
Journal of molecular cell biology
Ma P,Li Y,Wang H,Mao B
Wed Aug 18 00:00:00 UTC 2021
Haploinsufficiency of the TDP43 ubiquitin E3 ligase RNF220 leads to ALS-like motor neuron defects in the mouse.
Journal of molecular cell biology
Ma P,Li Y,Wang H,Mao B
Wed Aug 18 00:00:00 UTC 2021
Haploinsufficiency of the TDP43 ubiquitin E3 ligase RNF220 leads to ALS-like motor neuron defects in the mouse.
Journal of molecular cell biology
Ma P,Li Y,Wang H,Mao B
Wed Aug 18 00:00:00 UTC 2021
Haploinsufficiency of the TDP43 ubiquitin E3 ligase RNF220 leads to ALS-like motor neuron defects in the mouse.
Journal of molecular cell biology
Ma P,Li Y,Wang H,Mao B
Wed Aug 18 00:00:00 UTC 2021
Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model.
Nature communications
Shibata T,Nagano K,Ueyama M,Ninomiya K,Hirose T,Nagai Y,Ishikawa K,Kawai G,Nakatani K
Mon Jan 11 00:00:00 UTC 2021
Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model.
Nature communications
Shibata T,Nagano K,Ueyama M,Ninomiya K,Hirose T,Nagai Y,Ishikawa K,Kawai G,Nakatani K
Mon Jan 11 00:00:00 UTC 2021
Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice.
Experimental neurology
Sieverding K,Ulmer J,Bruno C,Satoh T,Tsao W,Freischmidt A,Akira S,Wong PC,Ludolph AC,Danzer KM,Lobsiger CS,Brenner D,Weishaupt JH
Fri Jan 01 00:00:00 UTC 2021
Long non-coding RNA NEAT1_1 ameliorates TDP-43 toxicity in in vivo models of TDP-43 proteinopathy.
RNA biology
Matsukawa K,Kukharsky MS,Park SK,Park S,Watanabe N,Iwatsubo T,Hashimoto T,Liebman SW,Shelkovnikova TA
Mon Nov 01 00:00:00 UTC 2021
Clinical and neuropathological diversity of tauopathy in MAPT duplication carriers.
Acta neuropathologica
Wallon D,Boluda S,Rovelet-Lecrux A,Thierry M,Lagarde J,Miguel L,Lecourtois M,Bonnevalle A,Sarazin M,Bottlaender M,Mula M,Marty S,Nakamura N,Schramm C,Sellal F,Jonveaux T,Heitz C,Le Ber I,Epelbaum S,Magnin E,Zarea A,Rousseau S,Quenez O,Hannequin D,Clavaguera F,Campion D,Duyckaerts C,Nicolas G
Sun Aug 01 00:00:00 UTC 2021
ATG14 and RB1CC1 play essential roles in maintaining muscle homeostasis.
Autophagy
Li D,Vogel P,Li-Harms X,Wang B,Kundu M
Wed Sep 01 00:00:00 UTC 2021
ATG14 and RB1CC1 play essential roles in maintaining muscle homeostasis.
Autophagy
Li D,Vogel P,Li-Harms X,Wang B,Kundu M
Wed Sep 01 00:00:00 UTC 2021
O-GlcNAcylation of TDP-43 suppresses proteinopathies and promotes TDP-43's mRNA splicing activity.
EMBO reports
Zhao MJ,Yao X,Wei P,Zhao C,Cheng M,Zhang D,Xue W,He WT,Xue W,Zuo X,Jiang LL,Luo Z,Song J,Shu WJ,Yuan HY,Liang Y,Sun H,Zhou Y,Zhou Y,Zheng L,Hu HY,Wang J,Du HN
Fri Jun 04 00:00:00 UTC 2021
O-GlcNAcylation of TDP-43 suppresses proteinopathies and promotes TDP-43's mRNA splicing activity.
EMBO reports
Zhao MJ,Yao X,Wei P,Zhao C,Cheng M,Zhang D,Xue W,He WT,Xue W,Zuo X,Jiang LL,Luo Z,Song J,Shu WJ,Yuan HY,Liang Y,Sun H,Zhou Y,Zhou Y,Zheng L,Hu HY,Wang J,Du HN
Fri Jun 04 00:00:00 UTC 2021
Drivers of Hsp104 potentiation revealed by scanning mutagenesis of the middle domain.
Protein science : a publication of the Protein Society
Ryan JJ,Bao A,Bell B,Ling C,Jackrel ME
Sun Aug 01 00:00:00 UTC 2021
Rapid in vitro quantification of TDP-43 and FUS mislocalisation for screening of gene variants implicated in frontotemporal dementia and amyotrophic lateral sclerosis.
Scientific reports
Oyston LJ,Ubiparipovic S,Fitzpatrick L,Hallupp M,Boccanfuso LM,Kwok JB,Dobson-Stone C
Wed Jul 21 00:00:00 UTC 2021
Rapid in vitro quantification of TDP-43 and FUS mislocalisation for screening of gene variants implicated in frontotemporal dementia and amyotrophic lateral sclerosis.
Scientific reports
Oyston LJ,Ubiparipovic S,Fitzpatrick L,Hallupp M,Boccanfuso LM,Kwok JB,Dobson-Stone C
Wed Jul 21 00:00:00 UTC 2021
Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis.
Acta neuropathologica
Diaz-Garcia S,Ko VI,Vazquez-Sanchez S,Chia R,Arogundade OA,Rodriguez MJ,Traynor BJ,Cleveland D,Ravits J
Wed Dec 01 00:00:00 UTC 2021
MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration.
Nature
Simone R,Javad F,Emmett W,Wilkins OG,Almeida FL,Barahona-Torres N,Zareba-Paslawska J,Ehteramyan M,Zuccotti P,Modelska A,Siva K,Virdi GS,Mitchell JS,Harley J,Kay VA,Hondhamuni G,Trabzuni D,Ryten M,Wray S,Preza E,Kia DA,Pittman A,Ferrari R,Manzoni C,Lees A,Hardy JA,Denti MA,Quattrone A,Patani R,Svenningsson P,Warner TT,Plagnol V,Ule J,de Silva R
Tue Jun 01 00:00:00 UTC 2021
TDP-43 proteinopathy impairs mRNP granule mediated postsynaptic translation and mRNA metabolism.
Theranostics
Wong CE,Jin LW,Chu YP,Wei WY,Ho PC,Tsai KJ
Thu Aug 05 00:00:00 UTC 2021
TDP-43 proteinopathy impairs mRNP granule mediated postsynaptic translation and mRNA metabolism.
Theranostics
Wong CE,Jin LW,Chu YP,Wei WY,Ho PC,Tsai KJ
Thu Aug 05 00:00:00 UTC 2021
TDP-43 proteinopathy impairs mRNP granule mediated postsynaptic translation and mRNA metabolism.
Theranostics
Wong CE,Jin LW,Chu YP,Wei WY,Ho PC,Tsai KJ
Thu Aug 05 00:00:00 UTC 2021
TDP-43 proteinopathy impairs mRNP granule mediated postsynaptic translation and mRNA metabolism.
Theranostics
Wong CE,Jin LW,Chu YP,Wei WY,Ho PC,Tsai KJ
Thu Aug 05 00:00:00 UTC 2021
TDP-43 proteinopathy impairs mRNP granule mediated postsynaptic translation and mRNA metabolism.
Theranostics
Wong CE,Jin LW,Chu YP,Wei WY,Ho PC,Tsai KJ
Thu Aug 05 00:00:00 UTC 2021
TDP-43 proteinopathy impairs mRNP granule mediated postsynaptic translation and mRNA metabolism.
Theranostics
Wong CE,Jin LW,Chu YP,Wei WY,Ho PC,Tsai KJ
Thu Aug 05 00:00:00 UTC 2021
Targeted Quantification of Detergent-Insoluble RNA-Binding Proteins in Human Brain Reveals Stage and Disease Specific Co-aggregation in Alzheimer's Disease.
Frontiers in molecular neuroscience
Guo Q,Dammer EB,Zhou M,Kundinger SR,Gearing M,Lah JJ,Levey AI,Shulman JM,Seyfried NT
Wed Apr 07 00:00:00 UTC 2021
FTLD Patient-Derived Fibroblasts Show Defective Mitochondrial Function and Accumulation of p62.
Molecular neurobiology
Leskelä S,Hoffmann D,Rostalski H,Huber N,Wittrahm R,Hartikainen P,Korhonen V,Leinonen V,Hiltunen M,Solje E,Remes AM,Haapasalo A
Mon Nov 01 00:00:00 UTC 2021
Globular glial tauopathy with a mutation in MAPT and unusual TDP-43 proteinopathy in a patient with behavioural-variant frontotemporal dementia.
Acta neuropathologica
Forrest SL,Shepherd CE,McCann H,Kwok JB,Halliday GM,Kril JJ
Sat May 01 00:00:00 UTC 2021
Globular glial tauopathy with a mutation in MAPT and unusual TDP-43 proteinopathy in a patient with behavioural-variant frontotemporal dementia.
Acta neuropathologica
Forrest SL,Shepherd CE,McCann H,Kwok JB,Halliday GM,Kril JJ
Sat May 01 00:00:00 UTC 2021
Multiple Sclerosis-Associated hnRNPA1 Mutations Alter hnRNPA1 Dynamics and Influence Stress Granule Formation.
International journal of molecular sciences
Clarke JWE,Thibault PA,Salapa HE,Kim DE,Hutchinson C,Levin MC
Fri Mar 12 00:00:00 UTC 2021
Neuronal VCP loss of function recapitulates FTLD-TDP pathology.
Cell reports
Wani A,Zhu J,Ulrich JD,Eteleeb A,Sauerbeck AD,Reitz SJ,Arhzaouy K,Ikenaga C,Yuede CM,Pittman SK,Wang F,Li S,Benitez BA,Cruchaga C,Kummer TT,Harari O,Chou TF,Schröder R,Clemen CS,Weihl CC
Tue Jul 20 00:00:00 UTC 2021
Neuronal VCP loss of function recapitulates FTLD-TDP pathology.
Cell reports
Wani A,Zhu J,Ulrich JD,Eteleeb A,Sauerbeck AD,Reitz SJ,Arhzaouy K,Ikenaga C,Yuede CM,Pittman SK,Wang F,Li S,Benitez BA,Cruchaga C,Kummer TT,Harari O,Chou TF,Schröder R,Clemen CS,Weihl CC
Tue Jul 20 00:00:00 UTC 2021
A novel temporal-predominant neuro-astroglial tauopathy associated with TMEM106B gene polymorphism in FTLD/ALS-TDP.
Brain pathology (Zurich, Switzerland)
Llibre-Guerra JJ,Lee SE,Suemoto CK,Ehrenberg AJ,Kovacs GG,Karydas A,Staffaroni A,Franca Resende EP,Kim EJ,Hwang JH,Ramos EM,Wojta KJ,Pasquini L,Pang SY,Spina S,Allen IE,Kramer J,Miller BL,Seeley WW,Grinberg LT
Mon Mar 01 00:00:00 UTC 2021
Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo ALS models.
Science translational medicine
Bush JA,Aikawa H,Fuerst R,Li Y,Ursu A,Meyer SM,Benhamou RI,Chen JL,Khan T,Wagner-Griffin S,Van Meter MJ,Tong Y,Olafson H,McKee KK,Childs-Disney JL,Gendron TF,Zhang Y,Coyne AN,Wang ET,Yildirim I,Wang KW,Petrucelli L,Rothstein JD,Disney MD
Wed Oct 27 00:00:00 UTC 2021
Enhanced detection of expanded repeat mRNA foci with hybridization chain reaction.
Acta neuropathologica communications
Glineburg MR,Zhang Y,Krans A,Tank EM,Barmada SJ,Todd PK
Fri Apr 23 00:00:00 UTC 2021
A novel recessive mutation affecting DNAJB6a causes myofibrillar myopathy.
Acta neuropathologica communications
Qian FY,Guo YD,Zu J,Zhang JH,Zheng YM,Abdoulaye IA,Pan ZH,Xie CM,Gao HC,Zhang ZJ
Mon Feb 08 00:00:00 UTC 2021
A novel recessive mutation affecting DNAJB6a causes myofibrillar myopathy.
Acta neuropathologica communications
Qian FY,Guo YD,Zu J,Zhang JH,Zheng YM,Abdoulaye IA,Pan ZH,Xie CM,Gao HC,Zhang ZJ
Mon Feb 08 00:00:00 UTC 2021
A novel recessive mutation affecting DNAJB6a causes myofibrillar myopathy.
Acta neuropathologica communications
Qian FY,Guo YD,Zu J,Zhang JH,Zheng YM,Abdoulaye IA,Pan ZH,Xie CM,Gao HC,Zhang ZJ
Mon Feb 08 00:00:00 UTC 2021
A novel recessive mutation affecting DNAJB6a causes myofibrillar myopathy.
Acta neuropathologica communications
Qian FY,Guo YD,Zu J,Zhang JH,Zheng YM,Abdoulaye IA,Pan ZH,Xie CM,Gao HC,Zhang ZJ
Mon Feb 08 00:00:00 UTC 2021
Axonal TDP-43 condensates drive neuromuscular junction disruption through inhibition of local synthesis of nuclear encoded mitochondrial proteins.
Nature communications
Altman T,Ionescu A,Ibraheem A,Priesmann D,Gradus-Pery T,Farberov L,Alexandra G,Shelestovich N,Dafinca R,Shomron N,Rage F,Talbot K,Ward ME,Dori A,Krüger M,Perlson E
Thu Nov 25 00:00:00 UTC 2021
Axonal TDP-43 condensates drive neuromuscular junction disruption through inhibition of local synthesis of nuclear encoded mitochondrial proteins.
Nature communications
Altman T,Ionescu A,Ibraheem A,Priesmann D,Gradus-Pery T,Farberov L,Alexandra G,Shelestovich N,Dafinca R,Shomron N,Rage F,Talbot K,Ward ME,Dori A,Krüger M,Perlson E
Thu Nov 25 00:00:00 UTC 2021
Characterization of the human TARDBP gene promoter.
Scientific reports
Baralle M,Romano M
Mon May 17 00:00:00 UTC 2021
Thioridazine reverts the phenotype in cellular and Drosophila models of amyotrophic lateral sclerosis by enhancing TDP-43 aggregate clearance.
Neurobiology of disease
Cragnaz L,Spinelli G,De Conti L,Bureau EA,Brownlees J,Feiguin F,Romano V,Skoko N,Klima R,Kettleborough CA,Baralle FE,Baralle M
Wed Dec 01 00:00:00 UTC 2021
Thioridazine reverts the phenotype in cellular and Drosophila models of amyotrophic lateral sclerosis by enhancing TDP-43 aggregate clearance.
Neurobiology of disease
Cragnaz L,Spinelli G,De Conti L,Bureau EA,Brownlees J,Feiguin F,Romano V,Skoko N,Klima R,Kettleborough CA,Baralle FE,Baralle M
Wed Dec 01 00:00:00 UTC 2021
Active lifestyle enhances protein expression profile in subjects with Lewy body pathology.
Dementia & neuropsychologia
Real CC,Suemoto CK,Binda KH,Grinberg LT,Pasqualucci CA,Jacob W,Ferretti-Rebustini REL,Nitrini R,Leite REP,de Britto LR
Fri Apr 22 00:00:00 UTC 2022
18F-AV-1451 positron emission tomography in neuropathological substrates of corticobasal syndrome.
Brain : a journal of neurology
Goodheart AE,Locascio JJ,Samore WR,Collins JA,Brickhouse M,Schultz A,Touroutoglou A,Johnson KA,Frosch MP,Growdon JH,Dickerson BC,Gomperts SN
Fri Feb 12 00:00:00 UTC 2021
Repeated Low-Level Blast Acutely Alters Brain Cytokines, Neurovascular Proteins, Mechanotransduction, and Neurodegenerative Markers in a Rat Model.
Frontiers in cellular neuroscience
Heyburn L,Abutarboush R,Goodrich S,Urioste R,Batuure A,Wheel J,Wilder DM,Arun P,Ahlers ST,Long JB,Sajja VS
Wed Mar 10 00:00:00 UTC 2021
TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells.
eLife
Chang KJ,Agrawal I,Vainshtein A,Ho WY,Xin W,Tucker-Kellogg G,Susuki K,Peles E,Ling SC,Chan JR
Wed Mar 10 00:00:00 UTC 2021
A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis.
Nature communications
Pradella D,Deflorian G,Pezzotta A,Di Matteo A,Belloni E,Campolungo D,Paradisi A,Bugatti M,Vermi W,Campioni M,Chiapparino A,Scietti L,Forneris F,Giampietro C,Volf N,Rehman M,Zacchigna S,Paronetto MP,Pistocchi A,Eichmann A,Mehlen P,Ghigna C
Wed Aug 11 00:00:00 UTC 2021
Identification of SRSF10 as a regulator of SMN2 ISS-N1.
Human mutation
Frederiksen SB,Holm LL,Larsen MR,Doktor TK,Andersen HS,Hastings ML,Hua Y,Krainer AR,Andresen BS
Mon Mar 01 00:00:00 UTC 2021
Polyadenylated RNA and RNA-Binding Proteins Exhibit Unique Response to Hyperosmotic Stress.
Frontiers in cell and developmental biology
Zaepfel BL,Rothstein JD
Wed Nov 08 00:00:00 UTC 2023
Phosphorylation of trans-active response DNA-binding protein-of 43 kDa promotes its cytoplasmic aggregation and modulates its function in tau mRNA stability and exon 10 alternative splicing.
Journal of neurochemistry
Wu R,Zhou D,Shen X,Chen F,Liu F,Gu J
Sun Aug 01 00:00:00 UTC 2021
Novel tankyrase inhibitors suppress TDP-43 aggregate formation.
Biochemical and biophysical research communications
Tanji K,Mori F,Shirai F,Fukami T,Seimiya H,Utsumi J,Kakita A,Wakabayashi K
Fri Jan 22 00:00:00 UTC 2021
Novel tankyrase inhibitors suppress TDP-43 aggregate formation.
Biochemical and biophysical research communications
Tanji K,Mori F,Shirai F,Fukami T,Seimiya H,Utsumi J,Kakita A,Wakabayashi K
Fri Jan 22 00:00:00 UTC 2021
Novel chemical inhibitor against SOD1 misfolding and aggregation protects neuron-loss and ameliorates disease symptoms in ALS mouse model.
Communications biology
Woo TG,Yoon MH,Kang SM,Park S,Cho JH,Hwang YJ,Ahn J,Jang H,Shin YJ,Jung EM,Ha NC,Kim BH,Kwon Y,Park BJ
Wed Dec 15 00:00:00 UTC 2021
Novel chemical inhibitor against SOD1 misfolding and aggregation protects neuron-loss and ameliorates disease symptoms in ALS mouse model.
Communications biology
Woo TG,Yoon MH,Kang SM,Park S,Cho JH,Hwang YJ,Ahn J,Jang H,Shin YJ,Jung EM,Ha NC,Kim BH,Kwon Y,Park BJ
Wed Dec 15 00:00:00 UTC 2021
The Periodontium Damage Induces Neuronal Cell Death in the Trigeminal Mesencephalic Nucleus and Neurodegeneration in the Trigeminal Motor Nucleus in C57BL/6J Mice.
Acta histochemica et cytochemica
Dhar A,Kuramoto E,Fukushima M,Iwai H,Yamanaka A,Goto T
Thu Feb 25 00:00:00 UTC 2021
Tideglusib, a Non-ATP Competitive Inhibitor of GSK-3β as a Drug Candidate for the Treatment of Amyotrophic Lateral Sclerosis.
International journal of molecular sciences
Martínez-González L,Gonzalo-Consuegra C,Gómez-Almería M,Porras G,de Lago E,Martín-Requero Á,Martínez A
Fri Aug 20 00:00:00 UTC 2021
A microfluidic approach to rescue ALS motor neuron degeneration using rapamycin.
Scientific reports
Chennampally P,Sayed-Zahid A,Soundararajan P,Sharp J,Cox GA,Collins SD,Smith RL
Mon Sep 13 00:00:00 UTC 2021
Stimulation of mTOR-independent autophagy and mitophagy by rilmenidine exacerbates the phenotype of transgenic TDP-43 mice.
Neurobiology of disease
Perera ND,Tomas D,Wanniarachchillage N,Cuic B,Luikinga SJ,Rytova V,Turner BJ
Thu Jul 01 00:00:00 UTC 2021
Stimulation of mTOR-independent autophagy and mitophagy by rilmenidine exacerbates the phenotype of transgenic TDP-43 mice.
Neurobiology of disease
Perera ND,Tomas D,Wanniarachchillage N,Cuic B,Luikinga SJ,Rytova V,Turner BJ
Thu Jul 01 00:00:00 UTC 2021
Extensive phenotypic characterisation of a human TDP-43Q331K transgenic mouse model of amyotrophic lateral sclerosis (ALS).
Scientific reports
Watkins JA,Alix JJP,Shaw PJ,Mead RJ
Tue Aug 17 00:00:00 UTC 2021
TDP-43 proteinopathy occurs independently of autophagic substrate accumulation and underlies nuclear defects in Niemann-Pick C disease.
Neuropathology and applied neurobiology
Liu EA,Mori E,Hamasaki F,Lieberman AP
Wed Dec 01 00:00:00 UTC 2021
Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency.
Nature
Zhang J,Velmeshev D,Hashimoto K,Huang YH,Hofmann JW,Shi X,Chen J,Leidal AM,Dishart JG,Cahill MK,Kelley KW,Liddelow SA,Seeley WW,Miller BL,Walther TC,Farese RV,Taylor JP,Ullian EM,Huang B,Debnath J,Wittmann T,Kriegstein AR,Huang EJ
Tue Dec 01 00:00:00 UTC 2020
The SINEB1 element in the long non-coding RNA Malat1 is necessary for TDP-43 proteostasis.
Nucleic acids research
Nguyen TM,Kabotyanski EB,Reineke LC,Shao J,Xiong F,Lee JH,Dubrulle J,Johnson H,Stossi F,Tsoi PS,Choi KJ,Ellis AG,Zhao N,Cao J,Adewunmi O,Ferreon JC,Ferreon ACM,Neilson JR,Mancini MA,Chen X,Kim J,Ma L,Li W,Rosen JM
Wed Mar 18 00:00:00 UTC 2020
Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36.
Neuron
McEachin ZT,Gendron TF,Raj N,García-Murias M,Banerjee A,Purcell RH,Ward PJ,Todd TW,Merritt-Garza ME,Jansen-West K,Hales CM,García-Sobrino T,Quintáns B,Holler CJ,Taylor G,San Millán B,Teijeira S,Yamashita T,Ohkubo R,Boulis NM,Xu C,Wen Z,Streichenberger N,Fogel BL,Kukar T,Abe K,Dickson DW,Arias M,Glass JD,Jiang J,Tansey MG,Sobrido MJ,Petrucelli L,Rossoll W,Bassell GJ
Wed Jul 22 00:00:00 UTC 2020
Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36.
Neuron
McEachin ZT,Gendron TF,Raj N,García-Murias M,Banerjee A,Purcell RH,Ward PJ,Todd TW,Merritt-Garza ME,Jansen-West K,Hales CM,García-Sobrino T,Quintáns B,Holler CJ,Taylor G,San Millán B,Teijeira S,Yamashita T,Ohkubo R,Boulis NM,Xu C,Wen Z,Streichenberger N,Fogel BL,Kukar T,Abe K,Dickson DW,Arias M,Glass JD,Jiang J,Tansey MG,Sobrido MJ,Petrucelli L,Rossoll W,Bassell GJ
Wed Jul 22 00:00:00 UTC 2020
G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD.
Neuron
Coyne AN,Zaepfel BL,Hayes L,Fitchman B,Salzberg Y,Luo EC,Bowen K,Trost H,Aigner S,Rigo F,Yeo GW,Harel A,Svendsen CN,Sareen D,Rothstein JD
Wed Sep 23 00:00:00 UTC 2020
CYLD is a causative gene for frontotemporal dementia - amyotrophic lateral sclerosis.
Brain : a journal of neurology
Dobson-Stone C,Hallupp M,Shahheydari H,Ragagnin AMG,Chatterton Z,Carew-Jones F,Shepherd CE,Stefen H,Paric E,Fath T,Thompson EM,Blumbergs P,Short CL,Field CD,Panegyres PK,Hecker J,Nicholson G,Shaw AD,Fullerton JM,Luty AA,Schofield PR,Brooks WS,Rajan N,Bennett MF,Bahlo M,Landers JE,Piguet O,Hodges JR,Halliday GM,Topp SD,Smith BN,Shaw CE,McCann E,Fifita JA,Williams KL,Atkin JD,Blair IP,Kwok JB
Sun Mar 01 00:00:00 UTC 2020
HDAC1 dysregulation induces aberrant cell cycle and DNA damage in progress of TDP-43 proteinopathies.
EMBO molecular medicine
Wu CC,Jin LW,Wang IF,Wei WY,Ho PC,Liu YC,Tsai KJ
Mon Jun 08 00:00:00 UTC 2020
HDAC1 dysregulation induces aberrant cell cycle and DNA damage in progress of TDP-43 proteinopathies.
EMBO molecular medicine
Wu CC,Jin LW,Wang IF,Wei WY,Ho PC,Liu YC,Tsai KJ
Mon Jun 08 00:00:00 UTC 2020
Cell-to-cell transmission of C9orf72 poly-(Gly-Ala) triggers key features of ALS/FTD.
The EMBO journal
Khosravi B,LaClair KD,Riemenschneider H,Zhou Q,Frottin F,Mareljic N,Czuppa M,Farny D,Hartmann H,Michaelsen M,Arzberger T,Hartl FU,Hipp MS,Edbauer D
Wed Apr 15 00:00:00 UTC 2020
Upregulation of ATG7 attenuates motor neuron dysfunction associated with depletion of TARDBP/TDP-43.
Autophagy
Donde A,Sun M,Jeong YH,Wen X,Ling J,Lin S,Braunstein K,Nie S,Wang S,Chen L,Wong PC
Wed Apr 01 00:00:00 UTC 2020
Upregulation of ATG7 attenuates motor neuron dysfunction associated with depletion of TARDBP/TDP-43.
Autophagy
Donde A,Sun M,Jeong YH,Wen X,Ling J,Lin S,Braunstein K,Nie S,Wang S,Chen L,Wong PC
Wed Apr 01 00:00:00 UTC 2020
Mutant C9orf72 human iPSC-derived astrocytes cause non-cell autonomous motor neuron pathophysiology.
Glia
Zhao C,Devlin AC,Chouhan AK,Selvaraj BT,Stavrou M,Burr K,Brivio V,He X,Mehta AR,Story D,Shaw CE,Dando O,Hardingham GE,Miles GB,Chandran S
Fri May 01 00:00:00 UTC 2020
An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress.
Neurobiology of disease
Feneberg E,Gordon D,Thompson AG,Finelli MJ,Dafinca R,Candalija A,Charles PD,Mäger I,Wood MJ,Fischer R,Kessler BM,Gray E,Turner MR,Talbot K
Thu Oct 01 00:00:00 UTC 2020
Reprogramming fibroblasts and peripheral blood cells from a C9ORF72 patient: A proof-of-principle study.
Journal of cellular and molecular medicine
Bardelli D,Sassone F,Colombrita C,Volpe C,Gumina V,Peverelli S,Catusi I,Ratti A,Silani V,Bossolasco P
Wed Apr 01 00:00:00 UTC 2020
TDP-43, a protein central to amyotrophic lateral sclerosis, is destabilized by tankyrase-1 and -2.
Journal of cell science
McGurk L,Rifai OM,Bonini NM
Tue Jun 23 00:00:00 UTC 2020
TDP-43, a protein central to amyotrophic lateral sclerosis, is destabilized by tankyrase-1 and -2.
Journal of cell science
McGurk L,Rifai OM,Bonini NM
Tue Jun 23 00:00:00 UTC 2020
TDP-43, a protein central to amyotrophic lateral sclerosis, is destabilized by tankyrase-1 and -2.
Journal of cell science
McGurk L,Rifai OM,Bonini NM
Tue Jun 23 00:00:00 UTC 2020
TDP-43, a protein central to amyotrophic lateral sclerosis, is destabilized by tankyrase-1 and -2.
Journal of cell science
McGurk L,Rifai OM,Bonini NM
Tue Jun 23 00:00:00 UTC 2020
Cdc48/VCP and Endocytosis Regulate TDP-43 and FUS Toxicity and Turnover.
Molecular and cellular biology
Liu G,Byrd A,Warner AN,Pei F,Basha E,Buchanan A,Buchan JR
Thu Jan 30 00:00:00 UTC 2020
BV-2 Microglial Cells Overexpressing C9orf72 Hexanucleotide Repeat Expansion Produce DPR Proteins and Show Normal Functionality but No RNA Foci.
Frontiers in neurology
Rostalski H,Hietanen T,Leskelä S,Behánová A,Abdollahzadeh A,Wittrahm R,Mäkinen P,Huber N,Hoffmann D,Solje E,Remes AM,Natunen T,Takalo M,Tohka J,Hiltunen M,Haapasalo A
Sat Oct 31 00:00:00 UTC 2020
BV-2 Microglial Cells Overexpressing C9orf72 Hexanucleotide Repeat Expansion Produce DPR Proteins and Show Normal Functionality but No RNA Foci.
Frontiers in neurology
Rostalski H,Hietanen T,Leskelä S,Behánová A,Abdollahzadeh A,Wittrahm R,Mäkinen P,Huber N,Hoffmann D,Solje E,Remes AM,Natunen T,Takalo M,Tohka J,Hiltunen M,Haapasalo A
Sat Oct 31 00:00:00 UTC 2020
The cellular expression and proteolytic processing of the amyloid precursor protein is independent of TDP-43.
Bioscience reports
Hicks DA,Jones AC,Pickering-Brown SM,Hooper NM
Thu Apr 30 00:00:00 UTC 2020
The cellular expression and proteolytic processing of the amyloid precursor protein is independent of TDP-43.
Bioscience reports
Hicks DA,Jones AC,Pickering-Brown SM,Hooper NM
Thu Apr 30 00:00:00 UTC 2020
Spinal Cord and Motor Neuron TDP-43 Pathology in a Sporadic Inclusion Body Myositis Patient.
Journal of neuropathology and experimental neurology
Cathcart SJ,Greene EP,Powell SZ,Arumanayagam AS,Rivera AL,Tawil R,Appel SH,Cykowski MD
Thu Oct 01 00:00:00 UTC 2020
Chronic stress induces formation of stress granules and pathological TDP-43 aggregates in human ALS fibroblasts and iPSC-motoneurons.
Neurobiology of disease
Ratti A,Gumina V,Lenzi P,Bossolasco P,Fulceri F,Volpe C,Bardelli D,Pregnolato F,Maraschi A,Fornai F,Silani V,Colombrita C
Sun Nov 01 00:00:00 UTC 2020
LSM12-EPAC1 defines a neuroprotective pathway that sustains the nucleocytoplasmic RAN gradient.
PLoS biology
Lee J,Park J,Kim JH,Lee G,Park TE,Yoon KJ,Kim YK,Lim C
Tue Dec 01 00:00:00 UTC 2020
TDP-43 transports ribosomal protein mRNA to regulate axonal local translation in neuronal axons.
Acta neuropathologica
Nagano S,Jinno J,Abdelhamid RF,Jin Y,Shibata M,Watanabe S,Hirokawa S,Nishizawa M,Sakimura K,Onodera O,Okada H,Okada T,Saito Y,Takahashi-Fujigasaki J,Murayama S,Wakatsuki S,Mochizuki H,Araki T
Sun Nov 01 00:00:00 UTC 2020
TDP-43 transports ribosomal protein mRNA to regulate axonal local translation in neuronal axons.
Acta neuropathologica
Nagano S,Jinno J,Abdelhamid RF,Jin Y,Shibata M,Watanabe S,Hirokawa S,Nishizawa M,Sakimura K,Onodera O,Okada H,Okada T,Saito Y,Takahashi-Fujigasaki J,Murayama S,Wakatsuki S,Mochizuki H,Araki T
Sun Nov 01 00:00:00 UTC 2020
Cytosolic calcium regulates cytoplasmic accumulation of TDP-43 through Calpain-A and Importin α3.
eLife
Park JH,Chung CG,Park SS,Lee D,Kim KM,Jeong Y,Kim ES,Cho JH,Jeon YM,Shen CJ,Kim HJ,Hwang D,Lee SB
Fri Dec 11 00:00:00 UTC 2020
Loss of TDP-43 in astrocytes leads to motor deficits by triggering A1-like reactive phenotype and triglial dysfunction.
Proceedings of the National Academy of Sciences of the United States of America
Peng AYT,Agrawal I,Ho WY,Yen YC,Pinter AJ,Liu J,Phua QXC,Koh KB,Chang JC,Sanford E,Man JHK,Wong P,Gutmann DH,Tucker-Kellogg G,Ling SC
Tue Nov 17 00:00:00 UTC 2020
Subcortical TDP-43 pathology patterns validate cortical FTLD-TDP subtypes and demonstrate unique aspects of C9orf72 mutation cases.
Acta neuropathologica
Mackenzie IR,Neumann M
Wed Jan 01 00:00:00 UTC 2020
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Cell reports
Haenig C,Atias N,Taylor AK,Mazza A,Schaefer MH,Russ J,Riechers SP,Jain S,Coughlin M,Fontaine JF,Freibaum BD,Brusendorf L,Zenkner M,Porras P,Stroedicke M,Schnoegl S,Arnsburg K,Boeddrich A,Pigazzini L,Heutink P,Taylor JP,Kirstein J,Andrade-Navarro MA,Sharan R,Wanker EE
Tue Aug 18 00:00:00 UTC 2020
Conditioned Medium from Cells Overexpressing TDP-43 Alters the Metabolome of Recipient Cells.
Cells
Hergesheimer R,Lanznaster D,Bourgeais J,Hérault O,Vourc'h P,Andres CR,Corcia P,Blasco H
Tue Sep 29 00:00:00 UTC 2020
Skeletal Muscle-Restricted Expression of Human SOD1 in Transgenic Mice Causes a Fatal ALS-Like Syndrome.
Frontiers in neurology
Martin LJ,Wong M
Fri Jan 01 00:00:00 UTC 2021
The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease.
Molecular therapy : the journal of the American Society of Gene Therapy
Monaco A,Maffia V,Sorrentino NC,Sambri I,Ezhova Y,Giuliano T,Cacace V,Nusco E,De Risi M,De Leonibus E,Schrader T,Klärner FG,Bitan G,Fraldi A
Wed Apr 08 00:00:00 UTC 2020
Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS.
Acta neuropathologica
LaClair KD,Zhou Q,Michaelsen M,Wefers B,Brill MS,Janjic A,Rathkolb B,Farny D,Cygan M,de Angelis MH,Wurst W,Neumann M,Enard W,Misgeld T,Arzberger T,Edbauer D
Sat Aug 01 00:00:00 UTC 2020
Influence of APOE genotype in primary age-related tauopathy.
Acta neuropathologica communications
Robinson AC,Davidson YS,Roncaroli F,Minshull J,Tinkler P,Horan MA,Payton A,Pendleton N,Mann DMA
Mon Dec 07 00:00:00 UTC 2020
Extracellular Vesicles Isolated from Human Induced Pluripotent Stem Cell-Derived Neurons Contain a Transcriptional Network.
Neurochemical research
Hicks DA,Jones AC,Corbett NJ,Fisher K,Pickering-Brown SM,Ashe MP,Hooper NM
Wed Jul 01 00:00:00 UTC 2020
Neurodegeneration-Associated Proteins in Human Olfactory Neurons Collected by Nasal Brushing.
Frontiers in neuroscience
Brozzetti L,Sacchetto L,Cecchini MP,Avesani A,Perra D,Bongianni M,Portioli C,Scupoli M,Ghetti B,Monaco S,Buffelli M,Zanusso G
Mon Sep 28 00:00:00 UTC 2020
The overexpression of TDP-43 in astrocytes causes neurodegeneration via a PTP1B-mediated inflammatory response.
Journal of neuroinflammation
Lee S,Kim S,Kang HY,Lim HR,Kwon Y,Jo M,Jeon YM,Kim SR,Kim K,Ha CM,Lee S,Kim HJ
Wed Oct 14 00:00:00 UTC 2020
Evidence of A Negative Feedback Network Between TDP-43 and miRNAs Dependent on TDP-43 Nuclear Localization.
Journal of molecular biology
Hawley ZCE,Campos-Melo D,Strong MJ
Fri Dec 04 00:00:00 UTC 2020
Evidence of A Negative Feedback Network Between TDP-43 and miRNAs Dependent on TDP-43 Nuclear Localization.
Journal of molecular biology
Hawley ZCE,Campos-Melo D,Strong MJ
Fri Dec 04 00:00:00 UTC 2020
The Impact of ALS-Associated Genes hnRNPA1, MATR3, VCP and UBQLN2 on the Severity of TDP-43 Aggregation.
Cells
Bajc Česnik A,Motaln H,Rogelj B
Tue Jul 28 00:00:00 UTC 2020
Mutant TDP-43 Expression Triggers TDP-43 Pathology and Cell Autonomous Effects on Primary Astrocytes: Implications for Non-cell Autonomous Pathology in ALS.
Neurochemical research
Barton SK,Lau CL,Chiam MDF,Tomas D,Muyderman H,Beart PM,Turner BJ
Mon Jun 01 00:00:00 UTC 2020
Mutant TDP-43 Expression Triggers TDP-43 Pathology and Cell Autonomous Effects on Primary Astrocytes: Implications for Non-cell Autonomous Pathology in ALS.
Neurochemical research
Barton SK,Lau CL,Chiam MDF,Tomas D,Muyderman H,Beart PM,Turner BJ
Mon Jun 01 00:00:00 UTC 2020
Revealing the Proteome of Motor Cortex Derived Extracellular Vesicles Isolated from Amyotrophic Lateral Sclerosis Human Postmortem Tissues.
Cells
Vassileff N,Vella LJ,Rajapaksha H,Shambrook M,Kenari AN,McLean C,Hill AF,Cheng L
Thu Jul 16 00:00:00 UTC 2020
TDP-43 proteinopathies: a new wave of neurodegenerative diseases.
Journal of neurology, neurosurgery, and psychiatry
de Boer EMJ,Orie VK,Williams T,Baker MR,De Oliveira HM,Polvikoski T,Silsby M,Menon P,van den Bos M,Halliday GM,van den Berg LH,Van Den Bosch L,van Damme P,Kiernan MC,van Es MA,Vucic S
Wed Nov 11 00:00:00 UTC 2020
Multiple system atrophy pathology is associated with primary Sjögren's syndrome.
JCI insight
Conway KS,Camelo-Piragua S,Fisher-Hubbard A,Perry WR,Shakkottai VG,Venneti S
Thu Aug 06 00:00:00 UTC 2020
ALS-derived fibroblasts exhibit reduced proliferation rate, cytoplasmic TDP-43 aggregation and a higher susceptibility to DNA damage.
Journal of neurology
Riancho J,Castanedo-Vázquez D,Gil-Bea F,Tapia O,Arozamena J,Durán-Vían C,Sedano MJ,Berciano MT,Lopez de Munain A,Lafarga M
Fri May 01 00:00:00 UTC 2020
Therapeutic genetic variation revealed in diverse Hsp104 homologs.
eLife
March ZM,Sweeney K,Kim H,Yan X,Castellano LM,Jackrel ME,Lin J,Chuang E,Gomes E,Willicott CW,Michalska K,Jedrzejczak RP,Joachimiak A,Caldwell KA,Caldwell GA,Shalem O,Shorter J
Tue Dec 15 00:00:00 UTC 2020
DeepCLIP: predicting the effect of mutations on protein-RNA binding with deep learning.
Nucleic acids research
Grønning AGB,Doktor TK,Larsen SJ,Petersen USS,Holm LL,Bruun GH,Hansen MB,Hartung AM,Baumbach J,Andresen BS
Mon Jul 27 00:00:00 UTC 2020
The Contribution of Vascular Pathology Toward Cognitive Impairment in Older Individuals with Intermediate Braak Stage Tau Pathology.
Journal of Alzheimer's disease : JAD
Robinson AC,Roncaroli F,Chew-Graham S,Davidson YS,Minshull J,Horan MA,Payton A,Pendleton N,Mann DMA
Thu Sep 09 00:00:00 UTC 2021
Motor neuron preservation and decrease of in vivo TDP-43 phosphorylation by protein CK-1δ kinase inhibitor treatment.
Scientific reports
Martínez-González L,Rodríguez-Cueto C,Cabezudo D,Bartolomé F,Andrés-Benito P,Ferrer I,Gil C,Martín-Requero Á,Fernández-Ruiz J,Martínez A,de Lago E
Tue Mar 10 00:00:00 UTC 2020
RNA-binding protein altered expression and mislocalization in MS.
Neurology(R) neuroimmunology & neuroinflammation
Masaki K,Sonobe Y,Ghadge G,Pytel P,Lépine P,Pernin F,Cui QL,Antel JP,Zandee S,Prat A,Roos RP
Fri May 01 00:00:00 UTC 2020
RNA-binding protein altered expression and mislocalization in MS.
Neurology(R) neuroimmunology & neuroinflammation
Masaki K,Sonobe Y,Ghadge G,Pytel P,Lépine P,Pernin F,Cui QL,Antel JP,Zandee S,Prat A,Roos RP
Fri May 01 00:00:00 UTC 2020
TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer's disease.
Nature communications
Shih YH,Tu LH,Chang TY,Ganesan K,Chang WW,Chang PS,Fang YS,Lin YT,Jin LW,Chen YR
Mon Nov 23 00:00:00 UTC 2020
Multiplexed chemogenetics in astrocytes and motoneurons restore blood-spinal cord barrier in ALS.
Life science alliance
Ouali Alami N,Tang L,Wiesner D,Commisso B,Bayer D,Weishaupt J,Dupuis L,Wong P,Baumann B,Wirth T,Boeckers TM,Yilmazer-Hanke D,Ludolph A,Roselli F
Sun Nov 01 00:00:00 UTC 2020
Optogenetic TDP-43 nucleation induces persistent insoluble species and progressive motor dysfunction in vivo.
Neurobiology of disease
Otte CG,Fortuna TR,Mann JR,Gleixner AM,Ramesh N,Pyles NJ,Pandey UB,Donnelly CJ
Tue Dec 01 00:00:00 UTC 2020
Optogenetic TDP-43 nucleation induces persistent insoluble species and progressive motor dysfunction in vivo.
Neurobiology of disease
Otte CG,Fortuna TR,Mann JR,Gleixner AM,Ramesh N,Pyles NJ,Pandey UB,Donnelly CJ
Tue Dec 01 00:00:00 UTC 2020
PTK2/FAK regulates UPS impairment via SQSTM1/p62 phosphorylation in TARDBP/TDP-43 proteinopathies.
Autophagy
Lee S,Jeon YM,Cha SJ,Kim S,Kwon Y,Jo M,Jang YN,Lee S,Kim J,Kim SR,Lee KJ,Lee SB,Kim K,Kim HJ
Sat Aug 01 00:00:00 UTC 2020
TDP-43 Related Neuropathologies and Phosphorylation State: Associations with Age and Clinical Dementia in the Cambridge City over-75s Cohort.
Journal of Alzheimer's disease : JAD
Hunter S,Hokkanen SRK,Keage HAD,Fleming J,Minett T,Polvikoski T,Allinson K,Brayne C
Mon May 10 00:00:00 UTC 2021
A role for SUMOylation in the Formation and Cellular Localization of TDP-43 Aggregates in Amyotrophic Lateral Sclerosis.
Molecular neurobiology
Maurel C,Chami AA,Thépault RA,Marouillat S,Blasco H,Corcia P,Andres CR,Vourc'h P
Sun Mar 01 00:00:00 UTC 2020
Analysis of ALS-related proteins during herpes simplex virus-2 latent infection.
Journal of neuroinflammation
Cabrera JR,Rodríguez-Izquierdo I,Jiménez JL,Muñoz-Fernández MÁ
Mon Dec 07 00:00:00 UTC 2020
Analysis of ALS-related proteins during herpes simplex virus-2 latent infection.
Journal of neuroinflammation
Cabrera JR,Rodríguez-Izquierdo I,Jiménez JL,Muñoz-Fernández MÁ
Mon Dec 07 00:00:00 UTC 2020
Elevation of casein kinase 1ε associated with TDP-43 and tau pathologies in Alzheimer's disease.
Brain pathology (Zurich, Switzerland)
Gu J,Hu W,Tan X,Qu S,Chu D,Gong CX,Iqbal K,Liu F
Sun Mar 01 00:00:00 UTC 2020
Elevation of casein kinase 1ε associated with TDP-43 and tau pathologies in Alzheimer's disease.
Brain pathology (Zurich, Switzerland)
Gu J,Hu W,Tan X,Qu S,Chu D,Gong CX,Iqbal K,Liu F
Sun Mar 01 00:00:00 UTC 2020
Accumulation of phosphorylated TDP-43 in the cytoplasm of Schwann cells in a case of sporadic amyotrophic lateral sclerosis.
Neuropathology : official journal of the Japanese Society of Neuropathology
Nakamura-Shindo K,Sakai K,Shimizu A,Ishida C,Yamada M
Tue Dec 01 00:00:00 UTC 2020
Novel monoclonal antibodies targeting the RRM2 domain of human TDP-43 protein.
Neuroscience letters
Trejo-Lopez JA,Sorrentino ZA,Riffe CJ,Lloyd GM,Labuzan SA,Dickson DW,Yachnis AT,Prokop S,Giasson BI
Sun Nov 01 00:00:00 UTC 2020
Novel monoclonal antibodies targeting the RRM2 domain of human TDP-43 protein.
Neuroscience letters
Trejo-Lopez JA,Sorrentino ZA,Riffe CJ,Lloyd GM,Labuzan SA,Dickson DW,Yachnis AT,Prokop S,Giasson BI
Sun Nov 01 00:00:00 UTC 2020
Novel monoclonal antibodies targeting the RRM2 domain of human TDP-43 protein.
Neuroscience letters
Trejo-Lopez JA,Sorrentino ZA,Riffe CJ,Lloyd GM,Labuzan SA,Dickson DW,Yachnis AT,Prokop S,Giasson BI
Sun Nov 01 00:00:00 UTC 2020
Novel monoclonal antibodies targeting the RRM2 domain of human TDP-43 protein.
Neuroscience letters
Trejo-Lopez JA,Sorrentino ZA,Riffe CJ,Lloyd GM,Labuzan SA,Dickson DW,Yachnis AT,Prokop S,Giasson BI
Sun Nov 01 00:00:00 UTC 2020
The Role of HDAC6 in TDP-43-Induced Neurotoxicity and UPS Impairment.
Frontiers in cell and developmental biology
Lee S,Kwon Y,Kim S,Jo M,Jeon YM,Cheon M,Lee S,Kim SR,Kim K,Kim HJ
Tue Dec 08 00:00:00 UTC 2020
TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh.
Nature communications
Zhao L,Ke H,Xu H,Wang GD,Zhang H,Zou L,Xiang S,Li M,Peng L,Zhou M,Li L,Ao L,Yang Q,Shen CJ,Yi P,Wang L,Jiao B
Fri Jan 17 00:00:00 UTC 2020
RBM45 associates with nuclear stress bodies and forms nuclear inclusions during chronic cellular stress and in neurodegenerative diseases.
Acta neuropathologica communications
Collins M,Li Y,Bowser R
Fri Jun 26 00:00:00 UTC 2020
Inhibition of DNAJ-HSP70 interaction improves strength in muscular dystrophy.
The Journal of clinical investigation
Bengoechea R,Findlay AR,Bhadra AK,Shao H,Stein KC,Pittman SK,Daw JA,Gestwicki JE,True HL,Weihl CC
Mon Aug 03 00:00:00 UTC 2020
Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions.
Cell reports
Hutten S,Usluer S,Bourgeois B,Simonetti F,Odeh HM,Fare CM,Czuppa M,Hruska-Plochan M,Hofweber M,Polymenidou M,Shorter J,Edbauer D,Madl T,Dormann D
Tue Dec 22 00:00:00 UTC 2020
Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions.
Cell reports
Hutten S,Usluer S,Bourgeois B,Simonetti F,Odeh HM,Fare CM,Czuppa M,Hruska-Plochan M,Hofweber M,Polymenidou M,Shorter J,Edbauer D,Madl T,Dormann D
Tue Dec 22 00:00:00 UTC 2020
Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase Separation.
Molecular cell
Wang C,Duan Y,Duan G,Wang Q,Zhang K,Deng X,Qian B,Gu J,Ma Z,Zhang S,Guo L,Liu C,Fang Y
Thu Aug 06 00:00:00 UTC 2020
Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase Separation.
Molecular cell
Wang C,Duan Y,Duan G,Wang Q,Zhang K,Deng X,Qian B,Gu J,Ma Z,Zhang S,Guo L,Liu C,Fang Y
Thu Aug 06 00:00:00 UTC 2020
An Experimental Model of Neurodegenerative Disease Based on Porcine Hemagglutinating Encephalomyelitis Virus-Related Lysosomal Abnormalities.
Molecular neurobiology
Lan Y,Li Z,Wang Z,Wang X,Wang G,Zhang J,Hu S,Zhao K,Xu B,Gao F,He W
Tue Dec 01 00:00:00 UTC 2020
An Experimental Model of Neurodegenerative Disease Based on Porcine Hemagglutinating Encephalomyelitis Virus-Related Lysosomal Abnormalities.
Molecular neurobiology
Lan Y,Li Z,Wang Z,Wang X,Wang G,Zhang J,Hu S,Zhao K,Xu B,Gao F,He W
Tue Dec 01 00:00:00 UTC 2020
Use of Capillary Electrophoresis Immunoassay to Search for Potential Biomarkers of Amyotrophic Lateral Sclerosis in Human Platelets.
Journal of visualized experiments : JoVE
Sage JM,Hall L,McVey A,Barohn RJ,Statland JM,Jawdat O,Dimachkie MM,Agbas A
Mon Feb 10 00:00:00 UTC 2020
Expanding the Phenotype of Frontotemporal Lobar Degeneration With FUS-Positive Pathology (FTLD-FUS).
Journal of neuropathology and experimental neurology
Chornenka K,Hirsch-Reinshagen V,Perez-Rosendahl M,Feldman H,Segal-Gidan F,Vinters HV,Mackenzie IR
Wed Jul 01 00:00:00 UTC 2020
Impaired NHEJ repair in amyotrophic lateral sclerosis is associated with TDP-43 mutations.
Molecular neurodegeneration
Konopka A,Whelan DR,Jamali MS,Perri E,Shahheydari H,Toth RP,Parakh S,Robinson T,Cheong A,Mehta P,Vidal M,Ragagnin AMG,Khizhnyak I,Jagaraj CJ,Galper J,Grima N,Deva A,Shadfar S,Nicholson GA,Yang S,Cutts SM,Horejsi Z,Bell TDM,Walker AK,Blair IP,Atkin JD
Wed Sep 09 00:00:00 UTC 2020
Human subiculo-fornico-mamillary system in Alzheimer's disease: Tau seeding by the pillar of the fornix.
Acta neuropathologica
Thierry M,Boluda S,Delatour B,Marty S,Seilhean D,Potier MC,Duyckaerts C
Sun Mar 01 00:00:00 UTC 2020
The effect and mechanism of 19S proteasome PSMD11/Rpn6 subunit in D-Galactose induced mimetic aging models.
Experimental cell research
Wu H,Sun H,He Z,Chen X,Li Y,Zhao X,Kong W,Kong W
Tue Sep 01 00:00:00 UTC 2020
Active poly-GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model.
EMBO molecular medicine
Zhou Q,Mareljic N,Michaelsen M,Parhizkar S,Heindl S,Nuscher B,Farny D,Czuppa M,Schludi C,Graf A,Krebs S,Blum H,Feederle R,Roth S,Haass C,Arzberger T,Liesz A,Edbauer D
Fri Feb 07 00:00:00 UTC 2020
All-Trans Retinoic Acid Exerts Neuroprotective Effects in Amyotrophic Lateral Sclerosis-Like Tg (SOD1*G93A)1Gur Mice.
Molecular neurobiology
Zhu Y,Liu Y,Yang F,Chen W,Jiang J,He P,Jiang S,Li M,Xu R
Sat Aug 01 00:00:00 UTC 2020
Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function.
Acta neuropathologica communications
Briese M,Saal-Bauernschubert L,Lüningschrör P,Moradi M,Dombert B,Surrey V,Appenzeller S,Deng C,Jablonka S,Sendtner M
Fri Jul 24 00:00:00 UTC 2020
Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function.
Acta neuropathologica communications
Briese M,Saal-Bauernschubert L,Lüningschrör P,Moradi M,Dombert B,Surrey V,Appenzeller S,Deng C,Jablonka S,Sendtner M
Fri Jul 24 00:00:00 UTC 2020
HDAC1 inhibition ameliorates TDP-43-induced cell death in vitro and in vivo.
Cell death & disease
Sanna S,Esposito S,Masala A,Sini P,Nieddu G,Galioto M,Fais M,Iaccarino C,Cestra G,Crosio C
Thu May 14 00:00:00 UTC 2020
HDAC1 inhibition ameliorates TDP-43-induced cell death in vitro and in vivo.
Cell death & disease
Sanna S,Esposito S,Masala A,Sini P,Nieddu G,Galioto M,Fais M,Iaccarino C,Cestra G,Crosio C
Thu May 14 00:00:00 UTC 2020
HDAC1 inhibition ameliorates TDP-43-induced cell death in vitro and in vivo.
Cell death & disease
Sanna S,Esposito S,Masala A,Sini P,Nieddu G,Galioto M,Fais M,Iaccarino C,Cestra G,Crosio C
Thu May 14 00:00:00 UTC 2020
HDAC1 inhibition ameliorates TDP-43-induced cell death in vitro and in vivo.
Cell death & disease
Sanna S,Esposito S,Masala A,Sini P,Nieddu G,Galioto M,Fais M,Iaccarino C,Cestra G,Crosio C
Thu May 14 00:00:00 UTC 2020
HDAC1 inhibition ameliorates TDP-43-induced cell death in vitro and in vivo.
Cell death & disease
Sanna S,Esposito S,Masala A,Sini P,Nieddu G,Galioto M,Fais M,Iaccarino C,Cestra G,Crosio C
Thu May 14 00:00:00 UTC 2020
HDAC1 inhibition ameliorates TDP-43-induced cell death in vitro and in vivo.
Cell death & disease
Sanna S,Esposito S,Masala A,Sini P,Nieddu G,Galioto M,Fais M,Iaccarino C,Cestra G,Crosio C
Thu May 14 00:00:00 UTC 2020
Sequestosome-1 (p62) expression reveals chaperone-assisted selective autophagy in immune-mediated necrotizing myopathies.
Brain pathology (Zurich, Switzerland)
Fischer N,Preuße C,Radke J,Pehl D,Allenbach Y,Schneider U,Feist E,von Casteleyn V,Hahn K,Ruck T,Meuth SG,Goebel HH,Graf R,Mammen A,Benveniste O,Stenzel W
Sun Mar 01 00:00:00 UTC 2020
Structural and mechanistic insights into Hsp104 function revealed by synchrotron X-ray footprinting.
The Journal of biological chemistry
Sweeny EA,Tariq A,Gurpinar E,Go MS,Sochor MA,Kan ZY,Mayne L,Englander SW,Shorter J
Fri Feb 07 00:00:00 UTC 2020
TDP-43 mediated blood-brain barrier permeability and leukocyte infiltration promote neurodegeneration in a low-grade systemic inflammation mouse model.
Journal of neuroinflammation
Zamudio F,Loon AR,Smeltzer S,Benyamine K,Navalpur Shanmugam NK,Stewart NJF,Lee DC,Nash K,Selenica MB
Sat Sep 26 00:00:00 UTC 2020
TDP-43 mediated blood-brain barrier permeability and leukocyte infiltration promote neurodegeneration in a low-grade systemic inflammation mouse model.
Journal of neuroinflammation
Zamudio F,Loon AR,Smeltzer S,Benyamine K,Navalpur Shanmugam NK,Stewart NJF,Lee DC,Nash K,Selenica MB
Sat Sep 26 00:00:00 UTC 2020
Overexpression of human wtTDP-43 causes impairment in hippocampal plasticity and behavioral deficits in CAMKII-tTa transgenic mouse model.
Molecular and cellular neurosciences
Quadri Z,Johnson N,Zamudio F,Miller A,Peters M,Smeltzer S,Hunt JB,Housley SB,Brown B,Kraner S,Norris CM,Nash K,Weeber E,Lee DC,Selenica MB
Wed Jan 01 00:00:00 UTC 2020
TDP-43 pathology in primary lateral sclerosis.
Amyotrophic lateral sclerosis & frontotemporal degeneration
Mackenzie IRA,Briemberg H
Sun Nov 01 00:00:00 UTC 2020
Stress Granule Assembly Can Facilitate but Is Not Required for TDP-43 Cytoplasmic Aggregation.
Biomolecules
Fernandes N,Nero L,Lyons SM,Ivanov P,Mittelmeier TM,Bolger TA,Buchan JR
Fri Sep 25 00:00:00 UTC 2020
Stress Granule Assembly Can Facilitate but Is Not Required for TDP-43 Cytoplasmic Aggregation.
Biomolecules
Fernandes N,Nero L,Lyons SM,Ivanov P,Mittelmeier TM,Bolger TA,Buchan JR
Fri Sep 25 00:00:00 UTC 2020
Amyotrophic Lateral Sclerosis Modifiers in Drosophila Reveal the Phospholipase D Pathway as a Potential Therapeutic Target.
Genetics
Kankel MW,Sen A,Lu L,Theodorou M,Dimlich DN,McCampbell A,Henderson CE,Shneider NA,Artavanis-Tsakonas S
Wed Jul 01 00:00:00 UTC 2020
Cytoplasmic localization of amyotrophic lateral sclerosis-related TDP-43 proteins modulates stress granule formation.
The European journal of neuroscience
Besnard-Guérin C
Thu Oct 01 00:00:00 UTC 2020
Cytoplasmic localization of amyotrophic lateral sclerosis-related TDP-43 proteins modulates stress granule formation.
The European journal of neuroscience
Besnard-Guérin C
Thu Oct 01 00:00:00 UTC 2020
Glutathione S-Transferase Rescues Motor Neuronal Toxicity in Fly Model of Amyotrophic Lateral Sclerosis.
Antioxidants (Basel, Switzerland)
Cha SJ,Han YJ,Choi HJ,Kim HJ,Kim K
Tue Jul 14 00:00:00 UTC 2020
Fabry Disease With Concomitant Lewy Body Disease.
Journal of neuropathology and experimental neurology
Del Tredici K,Ludolph AC,Feldengut S,Jacob C,Reichmann H,Bohl JR,Braak H
Wed Apr 01 00:00:00 UTC 2020
The vulnerability of motor and frontal cortex-dependent behaviors in mice expressing ALS-linked mutation in TDP-43.
Neurobiology of aging
Wong P,Ho WY,Yen YC,Sanford E,Ling SC
Sat Aug 01 00:00:00 UTC 2020
The vulnerability of motor and frontal cortex-dependent behaviors in mice expressing ALS-linked mutation in TDP-43.
Neurobiology of aging
Wong P,Ho WY,Yen YC,Sanford E,Ling SC
Sat Aug 01 00:00:00 UTC 2020
SOD1 p.D12Y variant is associated with amyotrophic lateral sclerosis/distal myopathy spectrum.
European journal of neurology
Tasca G,Lattante S,Marangi G,Conte A,Bernardo D,Bisogni G,Mandich P,Zollino M,Ragozzino E,Udd B,Sabatelli M
Wed Jul 01 00:00:00 UTC 2020
A Comparative Study of Pathological Outcomes in The University of Manchester Longitudinal Study of Cognition in Normal Healthy Old Age and Brains for Dementia Research Cohorts.
Journal of Alzheimer's disease : JAD
Robinson AC,Chew-Graham S,Davidson YS,Horan MA,Roncaroli F,Minshull J,du Plessis D,Pal P,Payton A,Pendleton N,Mann DMA
Wed Nov 18 00:00:00 UTC 2020
Antibody against TDP-43 phosphorylated at serine 375 suggests conformational differences of TDP-43 aggregates among FTLD-TDP subtypes.
Acta neuropathologica
Neumann M,Frick P,Paron F,Kosten J,Buratti E,Mackenzie IR
Sun Nov 01 00:00:00 UTC 2020
Antibody against TDP-43 phosphorylated at serine 375 suggests conformational differences of TDP-43 aggregates among FTLD-TDP subtypes.
Acta neuropathologica
Neumann M,Frick P,Paron F,Kosten J,Buratti E,Mackenzie IR
Sun Nov 01 00:00:00 UTC 2020
18F-flortaucipir PET to autopsy comparisons in Alzheimer's disease and other neurodegenerative diseases.
Brain : a journal of neurology
Soleimani-Meigooni DN,Iaccarino L,La Joie R,Baker S,Bourakova V,Boxer AL,Edwards L,Eser R,Gorno-Tempini ML,Jagust WJ,Janabi M,Kramer JH,Lesman-Segev OH,Mellinger T,Miller BL,Pham J,Rosen HJ,Spina S,Seeley WW,Strom A,Grinberg LT,Rabinovici GD
Sat Dec 05 00:00:00 UTC 2020
Changes to the TDP-43 and FUS Interactomes Induced by DNA Damage.
Journal of proteome research
Kawaguchi T,Rollins MG,Moinpour M,Morera AA,Ebmeier CC,Old WM,Schwartz JC
Fri Jan 03 00:00:00 UTC 2020
Characteristic Features of FUS Inclusions in Spinal Motor Neurons of Sporadic Amyotrophic Lateral Sclerosis.
Journal of neuropathology and experimental neurology
Ikenaka K,Ishigaki S,Iguchi Y,Kawai K,Fujioka Y,Yokoi S,Abdelhamid RF,Nagano S,Mochizuki H,Katsuno M,Sobue G
Wed Apr 01 00:00:00 UTC 2020
Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation.
Frontiers in molecular neuroscience
Ormeño F,Hormazabal J,Moreno J,Riquelme F,Rios J,Criollo A,Albornoz A,Alfaro IE,Budini M
Mon Sep 28 00:00:00 UTC 2020
Sensitivity-Specificity of Tau and Amyloid β Positron Emission Tomography in Frontotemporal Lobar Degeneration.
Annals of neurology
Ghirelli A,Tosakulwong N,Weigand SD,Clark HM,Ali F,Botha H,Duffy JR,Utianski RL,Buciuc M,Murray ME,Labuzan SA,Spychalla AJ,Pham NTT,Schwarz CG,Senjem ML,Machulda MM,Baker M,Rademakers R,Filippi M,Jack CR,Lowe VJ,Parisi JE,Dickson DW,Josephs KA,Whitwell JL
Sun Nov 01 00:00:00 UTC 2020
Diagnostic and prognostic values of PBMC proteins in amyotrophic lateral sclerosis.
Neurobiology of disease
Luotti S,Pasetto L,Porcu L,Torri V,Elezgarai SR,Pantalone S,Filareti M,Corbo M,Lunetta C,Mora G,Bonetto V
Mon Jun 01 00:00:00 UTC 2020
Forced isoform switching of Neat1_1 to Neat1_2 leads to the loss of Neat1_1 and the hyperformation of paraspeckles but does not affect the development and growth of mice.
RNA (New York, N.Y.)
Isobe M,Toya H,Mito M,Chiba T,Asahara H,Hirose T,Nakagawa S
Sun Mar 01 00:00:00 UTC 2020
Transmission of ALS pathogenesis by the cerebrospinal fluid.
Acta neuropathologica communications
Mishra PS,Boutej H,Soucy G,Bareil C,Kumar S,Picher-Martel V,Dupré N,Kriz J,Julien JP
Thu May 07 00:00:00 UTC 2020
Transmission of ALS pathogenesis by the cerebrospinal fluid.
Acta neuropathologica communications
Mishra PS,Boutej H,Soucy G,Bareil C,Kumar S,Picher-Martel V,Dupré N,Kriz J,Julien JP
Thu May 07 00:00:00 UTC 2020
Transmission of ALS pathogenesis by the cerebrospinal fluid.
Acta neuropathologica communications
Mishra PS,Boutej H,Soucy G,Bareil C,Kumar S,Picher-Martel V,Dupré N,Kriz J,Julien JP
Thu May 07 00:00:00 UTC 2020
Transmission of ALS pathogenesis by the cerebrospinal fluid.
Acta neuropathologica communications
Mishra PS,Boutej H,Soucy G,Bareil C,Kumar S,Picher-Martel V,Dupré N,Kriz J,Julien JP
Thu May 07 00:00:00 UTC 2020
Multiple distinct pathways lead to hyperubiquitylated insoluble TDP-43 protein independent of its translocation into stress granules.
The Journal of biological chemistry
Hans F,Glasebach H,Kahle PJ
Fri Jan 17 00:00:00 UTC 2020
Modeling of Frontotemporal Dementia Using iPSC Technology.
International journal of molecular sciences
Kim M,Kim HJ,Koh W,Li L,Heo H,Cho H,Lyoo CH,Seo SW,Kim EJ,Nakanishi M,Na DL,Song J
Mon Jul 27 00:00:00 UTC 2020
Modeling of Frontotemporal Dementia Using iPSC Technology.
International journal of molecular sciences
Kim M,Kim HJ,Koh W,Li L,Heo H,Cho H,Lyoo CH,Seo SW,Kim EJ,Nakanishi M,Na DL,Song J
Mon Jul 27 00:00:00 UTC 2020
Endoplasmic Reticulum Stress Signalling Induces Casein Kinase 1-Dependent Formation of Cytosolic TDP-43 Inclusions in Motor Neuron-Like Cells.
Neurochemical research
Hicks DA,Cross LL,Williamson R,Rattray M
Mon Jun 01 00:00:00 UTC 2020
Endoplasmic Reticulum Stress Signalling Induces Casein Kinase 1-Dependent Formation of Cytosolic TDP-43 Inclusions in Motor Neuron-Like Cells.
Neurochemical research
Hicks DA,Cross LL,Williamson R,Rattray M
Mon Jun 01 00:00:00 UTC 2020
Clinical and pathologic phenotype of a large family with heterozygous STUB1 mutation.
Neurology. Genetics
Mol MO,van Rooij JGJ,Brusse E,Verkerk AJMH,Melhem S,den Dunnen WFA,Rizzu P,Cupidi C,van Swieten JC,Donker Kaat L
Mon Jun 01 00:00:00 UTC 2020
From the Entorhinal Region via the Prosubiculum to the Dentate Fascia: Alzheimer Disease-Related Neurofibrillary Changes in the Temporal Allocortex.
Journal of neuropathology and experimental neurology
Braak H,Del Tredici K
Sat Feb 01 00:00:00 UTC 2020
A robust TDP-43 knock-in mouse model of ALS.
Acta neuropathologica communications
Huang SL,Wu LS,Lee M,Chang CW,Cheng WC,Fang YS,Chen YR,Cheng PL,Shen CJ
Tue Jan 21 00:00:00 UTC 2020
A robust TDP-43 knock-in mouse model of ALS.
Acta neuropathologica communications
Huang SL,Wu LS,Lee M,Chang CW,Cheng WC,Fang YS,Chen YR,Cheng PL,Shen CJ
Tue Jan 21 00:00:00 UTC 2020
Mitigation of ALS Pathology by Neuron-Specific Inhibition of Nuclear Factor Kappa B Signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Dutta K,Thammisetty SS,Boutej H,Bareil C,Julien JP
Wed Jun 24 00:00:00 UTC 2020
Calpain-1 and Calpain-2 in the Brain: New Evidence for a Critical Role of Calpain-2 in Neuronal Death.
Cells
Wang Y,Liu Y,Bi X,Baudry M
Wed Dec 16 00:00:00 UTC 2020
Cognitive deficit, and neuropathological correlates, in the oldest-old.
Revue neurologique
Verny M,Duyckaerts C
Sun Nov 01 00:00:00 UTC 2020
Isolation and characterization of antibody fragments selective for human FTD brain derived TDP-43 variants.
BMC neuroscience
Venkataraman L,He P,Khan G,Harris BT,Sierks MR
Fri Sep 04 00:00:00 UTC 2020
Absence of Subcerebral Projection Neurons Is Beneficial in a Mouse Model of Amyotrophic Lateral Sclerosis.
Annals of neurology
Burg T,Bichara C,Scekic-Zahirovic J,Fischer M,Stuart-Lopez G,Brunet A,Lefebvre F,Cordero-Erausquin M,Rouaux C
Thu Oct 01 00:00:00 UTC 2020
Sigma-1 receptor is a key genetic modulator in amyotrophic lateral sclerosis.
Human molecular genetics
Couly S,Khalil B,Viguier V,Roussel J,Maurice T,Liévens JC
Fri Mar 13 00:00:00 UTC 2020
Cytoplasmic mislocalization and mitochondrial colocalization of TDP-43 are common features between normal aged and young mice.
Experimental biology and medicine (Maywood, N.J.)
Termsarasab P,Thammongkolchai T,Gao J,Wang L,Liang J,Wang X
Sun Nov 01 00:00:00 UTC 2020
Modeling UBQLN2-mediated neurodegenerative disease in mice: Shared and divergent properties of wild type and mutant UBQLN2 in phase separation, subcellular localization, altered proteostasis pathways, and selective cytotoxicity.
Neurobiology of disease
Sharkey LM,Sandoval-Pistorius SS,Moore SJ,Gerson JE,Komlo R,Fischer S,Negron-Rios KY,Crowley EV,Padron F,Patel R,Murphy GG,Paulson HL
Tue Sep 01 00:00:00 UTC 2020
Functional analysis of proposed substrate-binding residues of Hsp104.
PloS one
Howard MK,Sohn BS,von Borcke J,Xu A,Jackrel ME
Tue Jun 23 00:00:00 UTC 2020
Astrocytes with TDP-43 inclusions exhibit reduced noradrenergic cAMP and Ca2+ signaling and dysregulated cell metabolism.
Scientific reports
Velebit J,Horvat A,Smolič T,Prpar Mihevc S,Rogelj B,Zorec R,Vardjan N
Tue Apr 07 00:00:00 UTC 2020
Nucleated transcriptional condensates amplify gene expression.
Nature cell biology
Wei MT,Chang YC,Shimobayashi SF,Shin Y,Strom AR,Brangwynne CP
Thu Oct 01 00:00:00 UTC 2020
A New Glycogen Storage Disease Caused by a Dominant PYGM Mutation.
Annals of neurology
Echaniz-Laguna A,Lornage X,Laforêt P,Orngreen MC,Edelweiss E,Brochier G,Bui MT,Silva-Rojas R,Birck C,Lannes B,Romero NB,Vissing J,Laporte J,Böhm J
Sat Aug 01 00:00:00 UTC 2020
TDP-43 mutations link Amyotrophic Lateral Sclerosis with R-loop homeostasis and R loop-mediated DNA damage.
PLoS genetics
Giannini M,Bayona-Feliu A,Sproviero D,Barroso SI,Cereda C,Aguilera A
Tue Dec 01 00:00:00 UTC 2020
TDP-43 mutations link Amyotrophic Lateral Sclerosis with R-loop homeostasis and R loop-mediated DNA damage.
PLoS genetics
Giannini M,Bayona-Feliu A,Sproviero D,Barroso SI,Cereda C,Aguilera A
Tue Dec 01 00:00:00 UTC 2020
Distinct molecular patterns of TDP-43 pathology in Alzheimer's disease: relationship with clinical phenotypes.
Acta neuropathologica communications
Tomé SO,Vandenberghe R,Ospitalieri S,Van Schoor E,Tousseyn T,Otto M,von Arnim CAF,Thal DR
Wed Apr 29 00:00:00 UTC 2020
Distinct molecular patterns of TDP-43 pathology in Alzheimer's disease: relationship with clinical phenotypes.
Acta neuropathologica communications
Tomé SO,Vandenberghe R,Ospitalieri S,Van Schoor E,Tousseyn T,Otto M,von Arnim CAF,Thal DR
Wed Apr 29 00:00:00 UTC 2020
Pathological Correlations of Neuropsychiatric Symptoms in Institutionalized People with Dementia.
Journal of Alzheimer's disease : JAD
Esteban de Antonio E,López-Álvarez J,Rábano A,Agüera-Ortiz L,Sánchez-Soblechero A,Amaya L,Portela S,Cátedra C,Olazarán J
Wed Sep 29 00:00:00 UTC 2021
RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether.
Cell
Liao YC,Fernandopulle MS,Wang G,Choi H,Hao L,Drerup CM,Patel R,Qamar S,Nixon-Abell J,Shen Y,Meadows W,Vendruscolo M,Knowles TPJ,Nelson M,Czekalska MA,Musteikyte G,Gachechiladze MA,Stephens CA,Pasolli HA,Forrest LR,St George-Hyslop P,Lippincott-Schwartz J,Ward ME
Thu Sep 19 00:00:00 UTC 2019
ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair.
Nature neuroscience
Klim JR,Williams LA,Limone F,Guerra San Juan I,Davis-Dusenbery BN,Mordes DA,Burberry A,Steinbaugh MJ,Gamage KK,Kirchner R,Moccia R,Cassel SH,Chen K,Wainger BJ,Woolf CJ,Eggan K
Fri Feb 01 00:00:00 UTC 2019
ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair.
Nature neuroscience
Klim JR,Williams LA,Limone F,Guerra San Juan I,Davis-Dusenbery BN,Mordes DA,Burberry A,Steinbaugh MJ,Gamage KK,Kirchner R,Moccia R,Cassel SH,Chen K,Wainger BJ,Woolf CJ,Eggan K
Fri Feb 01 00:00:00 UTC 2019
ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair.
Nature neuroscience
Klim JR,Williams LA,Limone F,Guerra San Juan I,Davis-Dusenbery BN,Mordes DA,Burberry A,Steinbaugh MJ,Gamage KK,Kirchner R,Moccia R,Cassel SH,Chen K,Wainger BJ,Woolf CJ,Eggan K
Fri Feb 01 00:00:00 UTC 2019
ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair.
Nature neuroscience
Klim JR,Williams LA,Limone F,Guerra San Juan I,Davis-Dusenbery BN,Mordes DA,Burberry A,Steinbaugh MJ,Gamage KK,Kirchner R,Moccia R,Cassel SH,Chen K,Wainger BJ,Woolf CJ,Eggan K
Fri Feb 01 00:00:00 UTC 2019
Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration.
Nature neuroscience
Melamed Z,López-Erauskin J,Baughn MW,Zhang O,Drenner K,Sun Y,Freyermuth F,McMahon MA,Beccari MS,Artates JW,Ohkubo T,Rodriguez M,Lin N,Wu D,Bennett CF,Rigo F,Da Cruz S,Ravits J,Lagier-Tourenne C,Cleveland DW
Fri Feb 01 00:00:00 UTC 2019
Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration.
Nature neuroscience
Melamed Z,López-Erauskin J,Baughn MW,Zhang O,Drenner K,Sun Y,Freyermuth F,McMahon MA,Beccari MS,Artates JW,Ohkubo T,Rodriguez M,Lin N,Wu D,Bennett CF,Rigo F,Da Cruz S,Ravits J,Lagier-Tourenne C,Cleveland DW
Fri Feb 01 00:00:00 UTC 2019
Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration.
Nature neuroscience
Melamed Z,López-Erauskin J,Baughn MW,Zhang O,Drenner K,Sun Y,Freyermuth F,McMahon MA,Beccari MS,Artates JW,Ohkubo T,Rodriguez M,Lin N,Wu D,Bennett CF,Rigo F,Da Cruz S,Ravits J,Lagier-Tourenne C,Cleveland DW
Fri Feb 01 00:00:00 UTC 2019
Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration.
Nature neuroscience
Melamed Z,López-Erauskin J,Baughn MW,Zhang O,Drenner K,Sun Y,Freyermuth F,McMahon MA,Beccari MS,Artates JW,Ohkubo T,Rodriguez M,Lin N,Wu D,Bennett CF,Rigo F,Da Cruz S,Ravits J,Lagier-Tourenne C,Cleveland DW
Fri Feb 01 00:00:00 UTC 2019
TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates.
Nature neuroscience
Laferrière F,Maniecka Z,Pérez-Berlanga M,Hruska-Plochan M,Gilhespy L,Hock EM,Wagner U,Afroz T,Boersema PJ,Barmettler G,Foti SC,Asi YT,Isaacs AM,Al-Amoudi A,Lewis A,Stahlberg H,Ravits J,De Giorgi F,Ichas F,Bezard E,Picotti P,Lashley T,Polymenidou M
Tue Jan 01 00:00:00 UTC 2019
TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates.
Nature neuroscience
Laferrière F,Maniecka Z,Pérez-Berlanga M,Hruska-Plochan M,Gilhespy L,Hock EM,Wagner U,Afroz T,Boersema PJ,Barmettler G,Foti SC,Asi YT,Isaacs AM,Al-Amoudi A,Lewis A,Stahlberg H,Ravits J,De Giorgi F,Ichas F,Bezard E,Picotti P,Lashley T,Polymenidou M
Tue Jan 01 00:00:00 UTC 2019
ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97.
Molecular cell
Wang B,Maxwell BA,Joo JH,Gwon Y,Messing J,Mishra A,Shaw TI,Ward AL,Quan H,Sakurada SM,Pruett-Miller SM,Bertorini T,Vogel P,Kim HJ,Peng J,Taylor JP,Kundu M
Thu May 16 00:00:00 UTC 2019
Cross-Regulation between TDP-43 and Paraspeckles Promotes Pluripotency-Differentiation Transition.
Molecular cell
Modic M,Grosch M,Rot G,Schirge S,Lepko T,Yamazaki T,Lee FCY,Rusha E,Shaposhnikov D,Palo M,Merl-Pham J,Cacchiarelli D,Rogelj B,Hauck SM,von Mering C,Meissner A,Lickert H,Hirose T,Ule J,Drukker M
Thu Jun 06 00:00:00 UTC 2019
Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain.
Science translational medicine
Wheeler JM,McMillan P,Strovas TJ,Liachko NF,Amlie-Wolf A,Kow RL,Klein RL,Szot P,Robinson L,Guthrie C,Saxton A,Kanaan NM,Raskind M,Peskind E,Trojanowski JQ,Lee VMY,Wang LS,Keene CD,Bird T,Schellenberg GD,Kraemer B
Wed Dec 18 00:00:00 UTC 2019
Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death.
Neuron
Gasset-Rosa F,Lu S,Yu H,Chen C,Melamed Z,Guo L,Shorter J,Da Cruz S,Cleveland DW
Wed Apr 17 00:00:00 UTC 2019
Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death.
Neuron
Gasset-Rosa F,Lu S,Yu H,Chen C,Melamed Z,Guo L,Shorter J,Da Cruz S,Cleveland DW
Wed Apr 17 00:00:00 UTC 2019
RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43.
Neuron
Mann JR,Gleixner AM,Mauna JC,Gomes E,DeChellis-Marks MR,Needham PG,Copley KE,Hurtle B,Portz B,Pyles NJ,Guo L,Calder CB,Wills ZP,Pandey UB,Kofler JK,Brodsky JL,Thathiah A,Shorter J,Donnelly CJ
Wed Apr 17 00:00:00 UTC 2019
Neurons selectively targeted in frontotemporal dementia reveal early stage TDP-43 pathobiology.
Acta neuropathologica
Nana AL,Sidhu M,Gaus SE,Hwang JL,Li L,Park Y,Kim EJ,Pasquini L,Allen IE,Rankin KP,Toller G,Kramer JH,Geschwind DH,Coppola G,Huang EJ,Grinberg LT,Miller BL,Seeley WW
Tue Jan 01 00:00:00 UTC 2019
Neurons selectively targeted in frontotemporal dementia reveal early stage TDP-43 pathobiology.
Acta neuropathologica
Nana AL,Sidhu M,Gaus SE,Hwang JL,Li L,Park Y,Kim EJ,Pasquini L,Allen IE,Rankin KP,Toller G,Kramer JH,Geschwind DH,Coppola G,Huang EJ,Grinberg LT,Miller BL,Seeley WW
Tue Jan 01 00:00:00 UTC 2019
Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction.
Neurobiology of disease
Gordon D,Dafinca R,Scaber J,Alegre-Abarrategui J,Farrimond L,Scott C,Biggs D,Kent L,Oliver PL,Davies B,Ansorge O,Wade-Martins R,Talbot K
Tue Jan 01 00:00:00 UTC 2019
Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction.
Neurobiology of disease
Gordon D,Dafinca R,Scaber J,Alegre-Abarrategui J,Farrimond L,Scott C,Biggs D,Kent L,Oliver PL,Davies B,Ansorge O,Wade-Martins R,Talbot K
Tue Jan 01 00:00:00 UTC 2019
Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction.
Neurobiology of disease
Gordon D,Dafinca R,Scaber J,Alegre-Abarrategui J,Farrimond L,Scott C,Biggs D,Kent L,Oliver PL,Davies B,Ansorge O,Wade-Martins R,Talbot K
Tue Jan 01 00:00:00 UTC 2019
Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction.
Neurobiology of disease
Gordon D,Dafinca R,Scaber J,Alegre-Abarrategui J,Farrimond L,Scott C,Biggs D,Kent L,Oliver PL,Davies B,Ansorge O,Wade-Martins R,Talbot K
Tue Jan 01 00:00:00 UTC 2019
Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction.
Neurobiology of disease
Gordon D,Dafinca R,Scaber J,Alegre-Abarrategui J,Farrimond L,Scott C,Biggs D,Kent L,Oliver PL,Davies B,Ansorge O,Wade-Martins R,Talbot K
Tue Jan 01 00:00:00 UTC 2019
Motor neuron degeneration, severe myopathy and TDP-43 increase in a transgenic pig model of SOD1-linked familiar ALS.
Neurobiology of disease
Crociara P,Chieppa MN,Vallino Costassa E,Berrone E,Gallo M,Lo Faro M,Pintore MD,Iulini B,D'Angelo A,Perona G,Botter A,Formicola D,Rainoldi A,Paulis M,Vezzoni P,Meli F,Peverali FA,Bendotti C,Trolese MC,Pasetto L,Bonetto V,Lazzari G,Duchi R,Perota A,Lagutina I,Quadalti C,Gennero MS,Dezzutto D,Desiato R,Boido M,Ghibaudi M,Valentini MC,Caramelli M,Galli C,Casalone C,Corona C
Mon Apr 01 00:00:00 UTC 2019
Motor neuron degeneration, severe myopathy and TDP-43 increase in a transgenic pig model of SOD1-linked familiar ALS.
Neurobiology of disease
Crociara P,Chieppa MN,Vallino Costassa E,Berrone E,Gallo M,Lo Faro M,Pintore MD,Iulini B,D'Angelo A,Perona G,Botter A,Formicola D,Rainoldi A,Paulis M,Vezzoni P,Meli F,Peverali FA,Bendotti C,Trolese MC,Pasetto L,Bonetto V,Lazzari G,Duchi R,Perota A,Lagutina I,Quadalti C,Gennero MS,Dezzutto D,Desiato R,Boido M,Ghibaudi M,Valentini MC,Caramelli M,Galli C,Casalone C,Corona C
Mon Apr 01 00:00:00 UTC 2019
Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events.
Structure (London, England : 1993)
Michalska K,Zhang K,March ZM,Hatzos-Skintges C,Pintilie G,Bigelow L,Castellano LM,Miles LJ,Jackrel ME,Chuang E,Jedrzejczak R,Shorter J,Chiu W,Joachimiak A
Tue Mar 05 00:00:00 UTC 2019
Memory Decline and Its Reversal in Aging and Neurodegeneration Involve miR-183/96/182 Biogenesis.
Molecular neurobiology
Jawaid A,Woldemichael BT,Kremer EA,Laferriere F,Gaur N,Afroz T,Polymenidou M,Mansuy IM
Wed May 01 00:00:00 UTC 2019
Memory Decline and Its Reversal in Aging and Neurodegeneration Involve miR-183/96/182 Biogenesis.
Molecular neurobiology
Jawaid A,Woldemichael BT,Kremer EA,Laferriere F,Gaur N,Afroz T,Polymenidou M,Mansuy IM
Wed May 01 00:00:00 UTC 2019
Memory Decline and Its Reversal in Aging and Neurodegeneration Involve miR-183/96/182 Biogenesis.
Molecular neurobiology
Jawaid A,Woldemichael BT,Kremer EA,Laferriere F,Gaur N,Afroz T,Polymenidou M,Mansuy IM
Wed May 01 00:00:00 UTC 2019
Recapitulation of Pathological TDP-43 Features in Immortalized Lymphocytes from Sporadic ALS Patients.
Molecular neurobiology
Posa D,Martínez-González L,Bartolomé F,Nagaraj S,Porras G,Martínez A,Martín-Requero Á
Mon Apr 01 00:00:00 UTC 2019
Recapitulation of Pathological TDP-43 Features in Immortalized Lymphocytes from Sporadic ALS Patients.
Molecular neurobiology
Posa D,Martínez-González L,Bartolomé F,Nagaraj S,Porras G,Martínez A,Martín-Requero Á
Mon Apr 01 00:00:00 UTC 2019
Neuronal Expression of UBQLN2P497H Exacerbates TDP-43 Pathology in TDP-43G348C Mice through Interaction with Ubiquitin.
Molecular neurobiology
Picher-Martel V,Renaud L,Bareil C,Julien JP
Mon Jul 01 00:00:00 UTC 2019
Neuronal Expression of UBQLN2P497H Exacerbates TDP-43 Pathology in TDP-43G348C Mice through Interaction with Ubiquitin.
Molecular neurobiology
Picher-Martel V,Renaud L,Bareil C,Julien JP
Mon Jul 01 00:00:00 UTC 2019
Neuronal Expression of UBQLN2P497H Exacerbates TDP-43 Pathology in TDP-43G348C Mice through Interaction with Ubiquitin.
Molecular neurobiology
Picher-Martel V,Renaud L,Bareil C,Julien JP
Mon Jul 01 00:00:00 UTC 2019
Neuronal Expression of UBQLN2P497H Exacerbates TDP-43 Pathology in TDP-43G348C Mice through Interaction with Ubiquitin.
Molecular neurobiology
Picher-Martel V,Renaud L,Bareil C,Julien JP
Mon Jul 01 00:00:00 UTC 2019
Neuronal Expression of UBQLN2P497H Exacerbates TDP-43 Pathology in TDP-43G348C Mice through Interaction with Ubiquitin.
Molecular neurobiology
Picher-Martel V,Renaud L,Bareil C,Julien JP
Mon Jul 01 00:00:00 UTC 2019
Pathological Modification of TDP-43 in Amyotrophic Lateral Sclerosis with SOD1 Mutations.
Molecular neurobiology
Jeon GS,Shim YM,Lee DY,Kim JS,Kang M,Ahn SH,Shin JY,Geum D,Hong YH,Sung JJ
Fri Mar 01 00:00:00 UTC 2019
Pathological Modification of TDP-43 in Amyotrophic Lateral Sclerosis with SOD1 Mutations.
Molecular neurobiology
Jeon GS,Shim YM,Lee DY,Kim JS,Kang M,Ahn SH,Shin JY,Geum D,Hong YH,Sung JJ
Fri Mar 01 00:00:00 UTC 2019
Pathological Modification of TDP-43 in Amyotrophic Lateral Sclerosis with SOD1 Mutations.
Molecular neurobiology
Jeon GS,Shim YM,Lee DY,Kim JS,Kang M,Ahn SH,Shin JY,Geum D,Hong YH,Sung JJ
Fri Mar 01 00:00:00 UTC 2019
Pathological Modification of TDP-43 in Amyotrophic Lateral Sclerosis with SOD1 Mutations.
Molecular neurobiology
Jeon GS,Shim YM,Lee DY,Kim JS,Kang M,Ahn SH,Shin JY,Geum D,Hong YH,Sung JJ
Fri Mar 01 00:00:00 UTC 2019
Pathological Modification of TDP-43 in Amyotrophic Lateral Sclerosis with SOD1 Mutations.
Molecular neurobiology
Jeon GS,Shim YM,Lee DY,Kim JS,Kang M,Ahn SH,Shin JY,Geum D,Hong YH,Sung JJ
Fri Mar 01 00:00:00 UTC 2019
Biomarkers for diseases with TDP-43 pathology.
Molecular and cellular neurosciences
Steinacker P,Barschke P,Otto M
Sat Jun 01 00:00:00 UTC 2019
Biomarkers for diseases with TDP-43 pathology.
Molecular and cellular neurosciences
Steinacker P,Barschke P,Otto M
Sat Jun 01 00:00:00 UTC 2019
Development of an automated capillary nano-immunoassay-Simple Western assay-to quantify total TDP43 protein in human platelet samples.
Analytical and bioanalytical chemistry
Fourier A,Escal J,Bernard E,Lachman I,Perret-Liaudet A,Leblanc P,Quadrio I
Tue Jan 01 00:00:00 UTC 2019
Development of an automated capillary nano-immunoassay-Simple Western assay-to quantify total TDP43 protein in human platelet samples.
Analytical and bioanalytical chemistry
Fourier A,Escal J,Bernard E,Lachman I,Perret-Liaudet A,Leblanc P,Quadrio I
Tue Jan 01 00:00:00 UTC 2019
Impaired Cu-Zn Superoxide Dismutase (SOD1) and Calcineurin (Cn) Interaction in ALS: A Presumed Consequence for TDP-43 and Zinc Aggregation in Tg SOD1G93A Rodent Spinal Cord Tissue.
Neurochemical research
Kim JM,Billington E,Reyes A,Notarianni T,Sage J,Agbas E,Taylor M,Monast I,Stanford JA,Agbas A
Tue Jan 01 00:00:00 UTC 2019
Impaired Cu-Zn Superoxide Dismutase (SOD1) and Calcineurin (Cn) Interaction in ALS: A Presumed Consequence for TDP-43 and Zinc Aggregation in Tg SOD1G93A Rodent Spinal Cord Tissue.
Neurochemical research
Kim JM,Billington E,Reyes A,Notarianni T,Sage J,Agbas E,Taylor M,Monast I,Stanford JA,Agbas A
Tue Jan 01 00:00:00 UTC 2019
TDP-43 levels are higher in platelets from patients with sporadic amyotrophic lateral sclerosis than in healthy controls.
Neurochemistry international
Hishizawa M,Yamashita H,Akizuki M,Urushitani M,Takahashi R
Fri Mar 01 00:00:00 UTC 2019
TDP-43 levels are higher in platelets from patients with sporadic amyotrophic lateral sclerosis than in healthy controls.
Neurochemistry international
Hishizawa M,Yamashita H,Akizuki M,Urushitani M,Takahashi R
Fri Mar 01 00:00:00 UTC 2019
Rasagiline for amyotrophic lateral sclerosis: A randomized, controlled trial.
Muscle & nerve
Statland JM,Moore D,Wang Y,Walsh M,Mozaffar T,Elman L,Nations SP,Mitsumoto H,Fernandes JA,Saperstein D,Hayat G,Herbelin L,Karam C,Katz J,Wilkins HM,Agbas A,Swerdlow RH,Santella RM,Dimachkie MM,Barohn RJ
Fri Feb 01 00:00:00 UTC 2019
Rasagiline for amyotrophic lateral sclerosis: A randomized, controlled trial.
Muscle & nerve
Statland JM,Moore D,Wang Y,Walsh M,Mozaffar T,Elman L,Nations SP,Mitsumoto H,Fernandes JA,Saperstein D,Hayat G,Herbelin L,Karam C,Katz J,Wilkins HM,Agbas A,Swerdlow RH,Santella RM,Dimachkie MM,Barohn RJ
Fri Feb 01 00:00:00 UTC 2019
Brain banking in low and middle-income countries: Raison D'être for the Ibadan Brain Ageing, Dementia And Neurodegeneration (IBADAN) Brain Bank Project.
Brain research bulletin
Akinyemi RO,Salami A,Akinyemi J,Ojagbemi A,Olopade F,Coker M,Farombi T,Nweke M,Arulogun O,Jegede A,Owolabi M,Kalaria RN,Ogunniyi A
Fri Feb 01 00:00:00 UTC 2019
Brain banking in low and middle-income countries: Raison D'être for the Ibadan Brain Ageing, Dementia And Neurodegeneration (IBADAN) Brain Bank Project.
Brain research bulletin
Akinyemi RO,Salami A,Akinyemi J,Ojagbemi A,Olopade F,Coker M,Farombi T,Nweke M,Arulogun O,Jegede A,Owolabi M,Kalaria RN,Ogunniyi A
Fri Feb 01 00:00:00 UTC 2019
Physiologically Important Electrolytes as Regulators of TDP-43 Aggregation and Droplet-Phase Behavior.
Biochemistry
Sun Y,Medina Cruz A,Hadley KC,Galant NJ,Law R,Vernon RM,Morris VK,Robertson J,Chakrabartty A
Tue Feb 12 00:00:00 UTC 2019
Physiologically Important Electrolytes as Regulators of TDP-43 Aggregation and Droplet-Phase Behavior.
Biochemistry
Sun Y,Medina Cruz A,Hadley KC,Galant NJ,Law R,Vernon RM,Morris VK,Robertson J,Chakrabartty A
Tue Feb 12 00:00:00 UTC 2019
Impaired Nucleoporins Are Present in Sporadic Amyotrophic Lateral Sclerosis Motor Neurons that Exhibit Mislocalization of the 43-kDa TAR DNA-Binding Protein.
Journal of clinical neurology (Seoul, Korea)
Aizawa H,Yamashita T,Kato H,Kimura T,Kwak S
Tue Jan 01 00:00:00 UTC 2019
Impaired Nucleoporins Are Present in Sporadic Amyotrophic Lateral Sclerosis Motor Neurons that Exhibit Mislocalization of the 43-kDa TAR DNA-Binding Protein.
Journal of clinical neurology (Seoul, Korea)
Aizawa H,Yamashita T,Kato H,Kimura T,Kwak S
Tue Jan 01 00:00:00 UTC 2019
Repeated Low-Level Blast Overpressure Leads to Endovascular Disruption and Alterations in TDP-43 and Piezo2 in a Rat Model of Blast TBI.
Frontiers in neurology
Heyburn L,Abutarboush R,Goodrich S,Urioste R,Batuure A,Statz J,Wilder D,Ahlers ST,Long JB,Sajja VSSS
Wed Sep 30 00:00:00 UTC 2020
Increased prevalence of granulovacuolar degeneration in C9orf72 mutation.
Acta neuropathologica
Riku Y,Duyckaerts C,Boluda S,Plu I,Le Ber I,Millecamps S,Salachas F,Yoshida M,Ando T,Katsuno M,Sobue G,Seilhean D
Fri Nov 01 00:00:00 UTC 2019
Drosophila Ref1/ALYREF regulates transcription and toxicity associated with ALS/FTD disease etiologies.
Acta neuropathologica communications
Berson A,Goodman LD,Sartoris AN,Otte CG,Aykit JA,Lee VM,Trojanowski JQ,Bonini NM
Mon Apr 29 00:00:00 UTC 2019
Altered immunoreactivity of ErbB4, a causative gene product for ALS19, in the spinal cord of patients with sporadic ALS.
Neuropathology : official journal of the Japanese Society of Neuropathology
Takahashi Y,Uchino A,Shioya A,Sano T,Matsumoto C,Numata-Uematsu Y,Nagano S,Araki T,Murayama S,Saito Y
Thu Aug 01 00:00:00 UTC 2019
Neuropathological lesions in the very old: results from a large Brazilian autopsy study.
Brain pathology (Zurich, Switzerland)
Suemoto CK,Leite REP,Ferretti-Rebustini REL,Rodriguez RD,Nitrini R,Pasqualucci CA,Jacob-Filho W,Grinberg LT
Fri Nov 01 00:00:00 UTC 2019
Neuronal TDP-43 depletion affects activity-dependent plasticity.
Neurobiology of disease
Koza P,Beroun A,Konopka A,Górkiewicz T,Bijoch L,Torres JC,Bulska E,Knapska E,Kaczmarek L,Konopka W
Tue Oct 01 00:00:00 UTC 2019
Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD.
Nature neuroscience
Goodman LD,Prudencio M,Kramer NJ,Martinez-Ramirez LF,Srinivasan AR,Lan M,Parisi MJ,Zhu Y,Chew J,Cook CN,Berson A,Gitler AD,Petrucelli L,Bonini NM
Sat Jun 01 00:00:00 UTC 2019
Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD.
Nature neuroscience
Goodman LD,Prudencio M,Kramer NJ,Martinez-Ramirez LF,Srinivasan AR,Lan M,Parisi MJ,Zhu Y,Chew J,Cook CN,Berson A,Gitler AD,Petrucelli L,Bonini NM
Sat Jun 01 00:00:00 UTC 2019
Neuroglial patterns are shared by cerebella from prion and prion-like disorder affected patients.
Mechanisms of ageing and development
Garcés M,Guijarro MI,Vargas A,Badiola JJ,Monzón M
Sun Dec 01 00:00:00 UTC 2019
Suppression of Progranulin Expression Leads to Formation of Intranuclear TDP-43 Inclusions In Vitro: A Cell Model of Frontotemporal Lobar Degeneration.
Journal of neuropathology and experimental neurology
Zhu J,Wang N,Li X,Zheng X,Zhao J,Xia H,Mao Q
Sun Dec 01 00:00:00 UTC 2019
Deletion of Tbk1 disrupts autophagy and reproduces behavioral and locomotor symptoms of FTD-ALS in mice.
Aging
Duan W,Guo M,Yi L,Zhang J,Bi Y,Liu Y,Li Y,Li Z,Ma Y,Zhang G,Liu Y,Song X,Li C
Tue Apr 30 00:00:00 UTC 2019
Deletion of Tbk1 disrupts autophagy and reproduces behavioral and locomotor symptoms of FTD-ALS in mice.
Aging
Duan W,Guo M,Yi L,Zhang J,Bi Y,Liu Y,Li Y,Li Z,Ma Y,Zhang G,Liu Y,Song X,Li C
Tue Apr 30 00:00:00 UTC 2019
Autosomal dominant mitochondrial membrane protein-associated neurodegeneration (MPAN).
Molecular genetics & genomic medicine
Gregory A,Lotia M,Jeong SY,Fox R,Zhen D,Sanford L,Hamada J,Jahic A,Beetz C,Freed A,Kurian MA,Cullup T,van der Weijden MCM,Nguyen V,Setthavongsack N,Garcia D,Krajbich V,Pham T,Woltjer R,George BP,Minks KQ,Paciorkowski AR,Hogarth P,Jankovic J,Hayflick SJ
Mon Jul 01 00:00:00 UTC 2019
Aggregation of the nucleic acid-binding protein TDP-43 occurs via distinct routes that are coordinated with stress granule formation.
The Journal of biological chemistry
Chen Y,Cohen TJ
Fri Mar 08 00:00:00 UTC 2019
Aggregation of the nucleic acid-binding protein TDP-43 occurs via distinct routes that are coordinated with stress granule formation.
The Journal of biological chemistry
Chen Y,Cohen TJ
Fri Mar 08 00:00:00 UTC 2019
Aggregation of the nucleic acid-binding protein TDP-43 occurs via distinct routes that are coordinated with stress granule formation.
The Journal of biological chemistry
Chen Y,Cohen TJ
Fri Mar 08 00:00:00 UTC 2019
Aggregation of the nucleic acid-binding protein TDP-43 occurs via distinct routes that are coordinated with stress granule formation.
The Journal of biological chemistry
Chen Y,Cohen TJ
Fri Mar 08 00:00:00 UTC 2019
Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells.
PloS one
Chadchankar J,Korboukh V,Conway LC,Wobst HJ,Walker CA,Doig P,Jacobsen SJ,Brandon NJ,Moss SJ,Wang Q
Mon Mar 23 00:00:00 UTC 2020
Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis.
eLife
Ling SC,Dastidar SG,Tokunaga S,Ho WY,Lim K,Ilieva H,Parone PA,Tyan SH,Tse TM,Chang JC,Platoshyn O,Bui NB,Bui A,Vetto A,Sun S,McAlonis-Downes M,Han JS,Swing D,Kapeli K,Yeo GW,Tessarollo L,Marsala M,Shaw CE,Tucker-Kellogg G,La Spada AR,Lagier-Tourenne C,Da Cruz S,Cleveland DW
Tue Feb 12 00:00:00 UTC 2019
Virus-mediated delivery of antibody targeting TAR DNA-binding protein-43 mitigates associated neuropathology.
The Journal of clinical investigation
Pozzi S,Thammisetty SS,Codron P,Rahimian R,Plourde KV,Soucy G,Bareil C,Phaneuf D,Kriz J,Gravel C,Julien JP
Mon Feb 25 00:00:00 UTC 2019
Virus-mediated delivery of antibody targeting TAR DNA-binding protein-43 mitigates associated neuropathology.
The Journal of clinical investigation
Pozzi S,Thammisetty SS,Codron P,Rahimian R,Plourde KV,Soucy G,Bareil C,Phaneuf D,Kriz J,Gravel C,Julien JP
Mon Feb 25 00:00:00 UTC 2019
Association between TDP-43 and mitochondria in inclusion body myositis.
Laboratory investigation; a journal of technical methods and pathology
Huntley ML,Gao J,Termsarasab P,Wang L,Zeng S,Thammongkolchai T,Liu Y,Cohen ML,Wang X
Mon Jul 01 00:00:00 UTC 2019
Association between TDP-43 and mitochondria in inclusion body myositis.
Laboratory investigation; a journal of technical methods and pathology
Huntley ML,Gao J,Termsarasab P,Wang L,Zeng S,Thammongkolchai T,Liu Y,Cohen ML,Wang X
Mon Jul 01 00:00:00 UTC 2019
Muscle pathology of hereditary motor and sensory neuropathy with proximal dominant involvement with TFG mutation.
Muscle & nerve
Yamashita S,Kimura E,Zhang Z,Tawara N,Hara K,Yoshimura A,Takashima H,Ando Y
Sun Dec 01 00:00:00 UTC 2019
Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation.
The Journal of biological chemistry
Chen JJ,Nathaniel DL,Raghavan P,Nelson M,Tian R,Tse E,Hong JY,See SK,Mok SA,Hein MY,Southworth DR,Grinberg LT,Gestwicki JE,Leonetti MD,Kampmann M
Fri Dec 13 00:00:00 UTC 2019
Splicing repression is a major function of TDP-43 in motor neurons.
Acta neuropathologica
Donde A,Sun M,Ling JP,Braunstein KE,Pang B,Wen X,Cheng X,Chen L,Wong PC
Fri Nov 01 00:00:00 UTC 2019
Splicing repression is a major function of TDP-43 in motor neurons.
Acta neuropathologica
Donde A,Sun M,Ling JP,Braunstein KE,Pang B,Wen X,Cheng X,Chen L,Wong PC
Fri Nov 01 00:00:00 UTC 2019
RRM adjacent TARDBP mutations disrupt RNA binding and enhance TDP-43 proteinopathy.
Brain : a journal of neurology
Chen HJ,Topp SD,Hui HS,Zacco E,Katarya M,McLoughlin C,King A,Smith BN,Troakes C,Pastore A,Shaw CE
Sun Dec 01 00:00:00 UTC 2019
RRM adjacent TARDBP mutations disrupt RNA binding and enhance TDP-43 proteinopathy.
Brain : a journal of neurology
Chen HJ,Topp SD,Hui HS,Zacco E,Katarya M,McLoughlin C,King A,Smith BN,Troakes C,Pastore A,Shaw CE
Sun Dec 01 00:00:00 UTC 2019
RRM adjacent TARDBP mutations disrupt RNA binding and enhance TDP-43 proteinopathy.
Brain : a journal of neurology
Chen HJ,Topp SD,Hui HS,Zacco E,Katarya M,McLoughlin C,King A,Smith BN,Troakes C,Pastore A,Shaw CE
Sun Dec 01 00:00:00 UTC 2019
Luminescent conjugated oligothiophenes distinguish between α-synuclein assemblies of Parkinson's disease and multiple system atrophy.
Acta neuropathologica communications
Klingstedt T,Ghetti B,Holton JL,Ling H,Nilsson KPR,Goedert M
Tue Dec 03 00:00:00 UTC 2019
Mutant TDP-43 Causes Early-Stage Dose-Dependent Motor Neuron Degeneration in a TARDBP Knockin Mouse Model of ALS.
Cell reports
Ebstein SY,Yagudayeva I,Shneider NA
Tue Jan 08 00:00:00 UTC 2019
Mutant TDP-43 Causes Early-Stage Dose-Dependent Motor Neuron Degeneration in a TARDBP Knockin Mouse Model of ALS.
Cell reports
Ebstein SY,Yagudayeva I,Shneider NA
Tue Jan 08 00:00:00 UTC 2019
Mutant TDP-43 Causes Early-Stage Dose-Dependent Motor Neuron Degeneration in a TARDBP Knockin Mouse Model of ALS.
Cell reports
Ebstein SY,Yagudayeva I,Shneider NA
Tue Jan 08 00:00:00 UTC 2019
Mutant TDP-43 Causes Early-Stage Dose-Dependent Motor Neuron Degeneration in a TARDBP Knockin Mouse Model of ALS.
Cell reports
Ebstein SY,Yagudayeva I,Shneider NA
Tue Jan 08 00:00:00 UTC 2019
Phase separation-deficient TDP43 remains functional in splicing.
Nature communications
Schmidt HB,Barreau A,Rohatgi R
Fri Oct 25 00:00:00 UTC 2019
Proteomic analysis reveals that wildtype and alanine-expanded nuclear poly(A)-binding protein exhibit differential interactions in skeletal muscle.
The Journal of biological chemistry
Banerjee A,Phillips BL,Deng Q,Seyfried NT,Pavlath GK,Vest KE,Corbett AH
Fri May 03 00:00:00 UTC 2019
Proteomic analysis reveals that wildtype and alanine-expanded nuclear poly(A)-binding protein exhibit differential interactions in skeletal muscle.
The Journal of biological chemistry
Banerjee A,Phillips BL,Deng Q,Seyfried NT,Pavlath GK,Vest KE,Corbett AH
Fri May 03 00:00:00 UTC 2019
18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes.
Alzheimer's research & therapy
Tsai RM,Bejanin A,Lesman-Segev O,LaJoie R,Visani A,Bourakova V,O'Neil JP,Janabi M,Baker S,Lee SE,Perry DC,Bajorek L,Karydas A,Spina S,Grinberg LT,Seeley WW,Ramos EM,Coppola G,Gorno-Tempini ML,Miller BL,Rosen HJ,Jagust W,Boxer AL,Rabinovici GD
Thu Jan 31 00:00:00 UTC 2019
Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity.
Cell reports
Tariq A,Lin J,Jackrel ME,Hesketh CD,Carman PJ,Mack KL,Weitzman R,Gambogi C,Hernandez Murillo OA,Sweeny EA,Gurpinar E,Yokom AL,Gates SN,Yee K,Sudesh S,Stillman J,Rizo AN,Southworth DR,Shorter J
Tue Aug 20 00:00:00 UTC 2019
PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins.
Cell research
Duan Y,Du A,Gu J,Duan G,Wang C,Gui X,Ma Z,Qian B,Deng X,Zhang K,Sun L,Tian K,Zhang Y,Jiang H,Liu C,Fang Y
Fri Mar 01 00:00:00 UTC 2019
PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins.
Cell research
Duan Y,Du A,Gu J,Duan G,Wang C,Gui X,Ma Z,Qian B,Deng X,Zhang K,Sun L,Tian K,Zhang Y,Jiang H,Liu C,Fang Y
Fri Mar 01 00:00:00 UTC 2019
TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response.
PLoS genetics
Wang P,Deng J,Dong J,Liu J,Bigio EH,Mesulam M,Wang T,Sun L,Wang L,Lee AY,McGee WA,Chen X,Fushimi K,Zhu L,Wu JY
Wed May 01 00:00:00 UTC 2019
Nopp140-mediated concentration of telomerase in Cajal bodies regulates telomere length.
Molecular biology of the cell
Bizarro J,Bhardwaj A,Smith S,Meier UT
Sun Dec 15 00:00:00 UTC 2019
The long noncoding RNA neuroLNC regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43.
Science advances
Keihani S,Kluever V,Mandad S,Bansal V,Rahman R,Fritsch E,Gomes LC,Gärtner A,Kügler S,Urlaub H,Wren JD,Bonn S,Rizzoli SO,Fornasiero EF
Sun Dec 01 00:00:00 UTC 2019
Corticobasal syndrome with visual hallucinations and probable REM-sleep behavior disorder: an autopsied case report of a patient with CBD and LBD pathology.
Neurocase
Naasan G,Shany-Ur T,Sidhu M,Barton C,Ketelle R,Shdo SM,Kramer JH,Miller BL,Seeley WW
Fri Dec 06 00:00:00 UTC 2019
Motor dysfunction and neurodegeneration in a C9orf72 mouse line expressing poly-PR.
Nature communications
Hao Z,Liu L,Tao Z,Wang R,Ren H,Sun H,Lin Z,Zhang Z,Mu C,Zhou J,Wang G
Tue Jul 02 00:00:00 UTC 2019
Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons.
JCI insight
Shi Y,Hung ST,Rocha G,Lin S,Linares GR,Staats KA,Seah C,Wang Y,Chickering M,Lai J,Sugawara T,Sagare AP,Zlokovic BV,Ichida JK
Tue Jul 16 00:00:00 UTC 2019
Detection of TAR DNA-binding protein 43 (TDP-43) oligomers as initial intermediate species during aggregate formation.
The Journal of biological chemistry
French RL,Grese ZR,Aligireddy H,Dhavale DD,Reeb AN,Kedia N,Kotzbauer PT,Bieschke J,Ayala YM
Fri Apr 26 00:00:00 UTC 2019
Detection of TAR DNA-binding protein 43 (TDP-43) oligomers as initial intermediate species during aggregate formation.
The Journal of biological chemistry
French RL,Grese ZR,Aligireddy H,Dhavale DD,Reeb AN,Kedia N,Kotzbauer PT,Bieschke J,Ayala YM
Fri Apr 26 00:00:00 UTC 2019
Heterogeneous Nuclear Ribonucleoprotein E2 (hnRNP E2) Is a Component of TDP-43 Aggregates Specifically in the A and C Pathological Subtypes of Frontotemporal Lobar Degeneration.
Frontiers in neuroscience
Kattuah W,Rogelj B,King A,Shaw CE,Hortobágyi T,Troakes C
Sat Jan 09 00:00:00 UTC 2021
TDP-43 regulates early-phase insulin secretion via CaV1.2-mediated exocytosis in islets.
The Journal of clinical investigation
Araki K,Araki A,Honda D,Izumoto T,Hashizume A,Hijikata Y,Yamada S,Iguchi Y,Hara A,Ikumi K,Kawai K,Ishigaki S,Nakamichi Y,Tsunekawa S,Seino Y,Yamamoto A,Takayama Y,Hidaka S,Tominaga M,Ohara-Imaizumi M,Suzuki A,Ishiguro H,Enomoto A,Yoshida M,Arima H,Muramatsu SI,Sobue G,Katsuno M
Mon Jul 29 00:00:00 UTC 2019
TDP-43 regulates early-phase insulin secretion via CaV1.2-mediated exocytosis in islets.
The Journal of clinical investigation
Araki K,Araki A,Honda D,Izumoto T,Hashizume A,Hijikata Y,Yamada S,Iguchi Y,Hara A,Ikumi K,Kawai K,Ishigaki S,Nakamichi Y,Tsunekawa S,Seino Y,Yamamoto A,Takayama Y,Hidaka S,Tominaga M,Ohara-Imaizumi M,Suzuki A,Ishiguro H,Enomoto A,Yoshida M,Arima H,Muramatsu SI,Sobue G,Katsuno M
Mon Jul 29 00:00:00 UTC 2019
TDP-43 regulates early-phase insulin secretion via CaV1.2-mediated exocytosis in islets.
The Journal of clinical investigation
Araki K,Araki A,Honda D,Izumoto T,Hashizume A,Hijikata Y,Yamada S,Iguchi Y,Hara A,Ikumi K,Kawai K,Ishigaki S,Nakamichi Y,Tsunekawa S,Seino Y,Yamamoto A,Takayama Y,Hidaka S,Tominaga M,Ohara-Imaizumi M,Suzuki A,Ishiguro H,Enomoto A,Yoshida M,Arima H,Muramatsu SI,Sobue G,Katsuno M
Mon Jul 29 00:00:00 UTC 2019
TDP-43 regulates early-phase insulin secretion via CaV1.2-mediated exocytosis in islets.
The Journal of clinical investigation
Araki K,Araki A,Honda D,Izumoto T,Hashizume A,Hijikata Y,Yamada S,Iguchi Y,Hara A,Ikumi K,Kawai K,Ishigaki S,Nakamichi Y,Tsunekawa S,Seino Y,Yamamoto A,Takayama Y,Hidaka S,Tominaga M,Ohara-Imaizumi M,Suzuki A,Ishiguro H,Enomoto A,Yoshida M,Arima H,Muramatsu SI,Sobue G,Katsuno M
Mon Jul 29 00:00:00 UTC 2019
Expanded polyglutamine impairs normal nuclear distribution of fused in sarcoma and poly (rC)-binding protein 1 in Huntington's disease.
Neuropathology : official journal of the Japanese Society of Neuropathology
Mori S,Honda H,Ishii T,Yoshimura M,Sasagasako N,Suzuki SO,Taniwaki T,Iwaki T
Tue Oct 01 00:00:00 UTC 2019
TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes.
Neurobiology of disease
LaRocca TJ,Mariani A,Watkins LR,Link CD
Sun Dec 01 00:00:00 UTC 2019
Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia.
Cell reports
Tam OH,Rozhkov NV,Shaw R,Kim D,Hubbard I,Fennessey S,Propp N,Fagegaltier D,Harris BT,Ostrow LW,Phatnani H,Ravits J,Dubnau J,Gale Hammell M
Tue Oct 29 00:00:00 UTC 2019
Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia.
Cell reports
Tam OH,Rozhkov NV,Shaw R,Kim D,Hubbard I,Fennessey S,Propp N,Fagegaltier D,Harris BT,Ostrow LW,Phatnani H,Ravits J,Dubnau J,Gale Hammell M
Tue Oct 29 00:00:00 UTC 2019
Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia.
Cell reports
Tam OH,Rozhkov NV,Shaw R,Kim D,Hubbard I,Fennessey S,Propp N,Fagegaltier D,Harris BT,Ostrow LW,Phatnani H,Ravits J,Dubnau J,Gale Hammell M
Tue Oct 29 00:00:00 UTC 2019
Myelin degeneration induced by mutant superoxide dismutase 1 accumulation promotes amyotrophic lateral sclerosis.
Glia
Kim S,Chung AY,Na JE,Lee SJ,Jeong SH,Kim E,Sun W,Rhyu IJ,Park HC
Tue Oct 01 00:00:00 UTC 2019
C-terminal and full length TDP-43 specie differ according to FTLD-TDP lesion type but not genetic mutation.
Acta neuropathologica communications
Josephs KA,Zhang YJ,Baker M,Rademakers R,Petrucelli L,Dickson DW
Tue Jul 02 00:00:00 UTC 2019
Clinicopathologic correlations in a family with a TBK1 mutation presenting as primary progressive aphasia and primary lateral sclerosis.
Amyotrophic lateral sclerosis & frontotemporal degeneration
Hirsch-Reinshagen V,Alfaify OA,Hsiung GR,Pottier C,Baker M,Perkerson RB,Rademakers R,Briemberg H,Foti DJ,Mackenzie IR
Fri Nov 01 00:00:00 UTC 2019
Genetic Regulation of Neuronal Progranulin Reveals a Critical Role for the Autophagy-Lysosome Pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Elia LP,Mason AR,Alijagic A,Finkbeiner S
Wed Apr 24 00:00:00 UTC 2019
Amyotrophic lateral sclerosis-associated TDP-43 mutation Q331K prevents nuclear translocation of XRCC4-DNA ligase 4 complex and is linked to genome damage-mediated neuronal apoptosis.
Human molecular genetics
Guerrero EN,Mitra J,Wang H,Rangaswamy S,Hegde PM,Basu P,Rao KS,Hegde ML
Thu Aug 01 00:00:00 UTC 2019
Amyotrophic lateral sclerosis-associated TDP-43 mutation Q331K prevents nuclear translocation of XRCC4-DNA ligase 4 complex and is linked to genome damage-mediated neuronal apoptosis.
Human molecular genetics
Guerrero EN,Mitra J,Wang H,Rangaswamy S,Hegde PM,Basu P,Rao KS,Hegde ML
Thu Aug 01 00:00:00 UTC 2019
Amyotrophic lateral sclerosis-associated TDP-43 mutation Q331K prevents nuclear translocation of XRCC4-DNA ligase 4 complex and is linked to genome damage-mediated neuronal apoptosis.
Human molecular genetics
Guerrero EN,Mitra J,Wang H,Rangaswamy S,Hegde PM,Basu P,Rao KS,Hegde ML
Thu Aug 01 00:00:00 UTC 2019
Persistent neuropathological effects 14 years following amyloid-β immunization in Alzheimer's disease.
Brain : a journal of neurology
Nicoll JAR,Buckland GR,Harrison CH,Page A,Harris S,Love S,Neal JW,Holmes C,Boche D
Mon Jul 01 00:00:00 UTC 2019
CYLD dysregulation in pathogenesis of sporadic inclusion body myositis.
Scientific reports
Yamashita S,Matsuo Y,Tawara N,Hara K,Yamamoto M,Nishikami T,Kawakami K,Zhang X,Zhang Z,Doki T,Ando Y
Mon Aug 12 00:00:00 UTC 2019
The Small Non-coding Vault RNA1-1 Acts as a Riboregulator of Autophagy.
Cell
Horos R,Büscher M,Kleinendorst R,Alleaume AM,Tarafder AK,Schwarzl T,Dziuba D,Tischer C,Zielonka EM,Adak A,Castello A,Huber W,Sachse C,Hentze MW
Thu Feb 21 00:00:00 UTC 2019
Dysregulation of TDP-43 intracellular localization and early onset ALS are associated with a TARDBP S375G variant.
Brain pathology (Zurich, Switzerland)
Newell K,Paron F,Mompean M,Murrell J,Salis E,Stuani C,Pattee G,Romano M,Laurents D,Ghetti B,Buratti E
Wed May 01 00:00:00 UTC 2019
Dysregulation of TDP-43 intracellular localization and early onset ALS are associated with a TARDBP S375G variant.
Brain pathology (Zurich, Switzerland)
Newell K,Paron F,Mompean M,Murrell J,Salis E,Stuani C,Pattee G,Romano M,Laurents D,Ghetti B,Buratti E
Wed May 01 00:00:00 UTC 2019
TDP-43 regulates transcription at protein-coding genes and Alu retrotransposons.
Biochimica et biophysica acta. Gene regulatory mechanisms
Morera AA,Ahmed NS,Schwartz JC
Tue Oct 01 00:00:00 UTC 2019
Phosphorylated TDP-43 aggregates in skeletal and cardiac muscle are a marker of myogenic degeneration in amyotrophic lateral sclerosis and various conditions.
Acta neuropathologica communications
Mori F,Tada M,Kon T,Miki Y,Tanji K,Kurotaki H,Tomiyama M,Ishihara T,Onodera O,Kakita A,Wakabayashi K
Mon Oct 28 00:00:00 UTC 2019
Developmental Expression of Mutant PFN1 in Motor Neurons Impacts Neuronal Growth and Motor Performance of Young and Adult Mice.
Frontiers in molecular neuroscience
Brettle M,Stefen H,Djordjevic A,Fok SYY,Chan JW,van Hummel A,van der Hoven J,Przybyla M,Volkerling A,Ke YD,Delerue F,Ittner LM,Fath T
Wed Sep 30 00:00:00 UTC 2020
Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia.
Acta pharmaceutica Sinica. B
Wu C,Xi C,Tong J,Zhao J,Jiang H,Wang J,Wang Y,Liu H
Fri Nov 01 00:00:00 UTC 2019
Loss of Nuclear TDP-43 Is Associated with Decondensation of LINE Retrotransposons.
Cell reports
Liu EY,Russ J,Cali CP,Phan JM,Amlie-Wolf A,Lee EB
Tue Apr 30 00:00:00 UTC 2019
VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.
Autophagy
Arhzaouy K,Papadopoulos C,Schulze N,Pittman SK,Meyer H,Weihl CC
Sat Jun 01 00:00:00 UTC 2019
Neuronal over-expression of Oxr1 is protective against ALS-associated mutant TDP-43 mislocalisation in motor neurons and neuromuscular defects in vivo.
Human molecular genetics
Williamson MG,Finelli MJ,Sleigh JN,Reddington A,Gordon D,Talbot K,Davies KE,Oliver PL
Fri Nov 01 00:00:00 UTC 2019
Neuronal over-expression of Oxr1 is protective against ALS-associated mutant TDP-43 mislocalisation in motor neurons and neuromuscular defects in vivo.
Human molecular genetics
Williamson MG,Finelli MJ,Sleigh JN,Reddington A,Gordon D,Talbot K,Davies KE,Oliver PL
Fri Nov 01 00:00:00 UTC 2019
Non-genetically modified models exhibit TARDBP mRNA increase due to perturbed TDP-43 autoregulation.
Neurobiology of disease
Sugai A,Kato T,Koyama A,Koike Y,Konno T,Ishihara T,Onodera O
Tue Oct 01 00:00:00 UTC 2019
TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle.
Nature
Vogler TO,Wheeler JR,Nguyen ED,Hughes MP,Britson KA,Lester E,Rao B,Betta ND,Whitney ON,Ewachiw TE,Gomes E,Shorter J,Lloyd TE,Eisenberg DS,Taylor JP,Johnson AM,Olwin BB,Parker R
Thu Nov 01 00:00:00 UTC 2018
TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle.
Nature
Vogler TO,Wheeler JR,Nguyen ED,Hughes MP,Britson KA,Lester E,Rao B,Betta ND,Whitney ON,Ewachiw TE,Gomes E,Shorter J,Lloyd TE,Eisenberg DS,Taylor JP,Johnson AM,Olwin BB,Parker R
Thu Nov 01 00:00:00 UTC 2018
TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle.
Nature
Vogler TO,Wheeler JR,Nguyen ED,Hughes MP,Britson KA,Lester E,Rao B,Betta ND,Whitney ON,Ewachiw TE,Gomes E,Shorter J,Lloyd TE,Eisenberg DS,Taylor JP,Johnson AM,Olwin BB,Parker R
Thu Nov 01 00:00:00 UTC 2018
Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome.
Cell
Shin Y,Chang YC,Lee DSW,Berry J,Sanders DW,Ronceray P,Wingreen NS,Haataja M,Brangwynne CP
Thu Nov 29 00:00:00 UTC 2018
Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome.
Cell
Shin Y,Chang YC,Lee DSW,Berry J,Sanders DW,Ronceray P,Wingreen NS,Haataja M,Brangwynne CP
Thu Nov 29 00:00:00 UTC 2018
TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging.
Cell
Xu D,Jin T,Zhu H,Chen H,Ofengeim D,Zou C,Mifflin L,Pan L,Amin P,Li W,Shan B,Naito MG,Meng H,Li Y,Pan H,Aron L,Adiconis X,Levin JZ,Yankner BA,Yuan J
Thu Sep 06 00:00:00 UTC 2018
TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging.
Cell
Xu D,Jin T,Zhu H,Chen H,Ofengeim D,Zou C,Mifflin L,Pan L,Amin P,Li W,Shan B,Naito MG,Meng H,Li Y,Pan H,Aron L,Adiconis X,Levin JZ,Yankner BA,Yuan J
Thu Sep 06 00:00:00 UTC 2018
Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization.
Molecular cell
McGurk L,Gomes E,Guo L,Mojsilovic-Petrovic J,Tran V,Kalb RG,Shorter J,Bonini NM
Thu Sep 06 00:00:00 UTC 2018
Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization.
Molecular cell
McGurk L,Gomes E,Guo L,Mojsilovic-Petrovic J,Tran V,Kalb RG,Shorter J,Bonini NM
Thu Sep 06 00:00:00 UTC 2018
Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal.
Molecular cell
Wen J,Lv R,Ma H,Shen H,He C,Wang J,Jiao F,Liu H,Yang P,Tan L,Lan F,Shi YG,He C,Shi Y,Diao J
Thu Mar 15 00:00:00 UTC 2018
Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal.
Molecular cell
Wen J,Lv R,Ma H,Shen H,He C,Wang J,Jiao F,Liu H,Yang P,Tan L,Lan F,Shi YG,He C,Shi Y,Diao J
Thu Mar 15 00:00:00 UTC 2018
TDP-43 regulates the alternative splicing of hnRNP A1 to yield an aggregation-prone variant in amyotrophic lateral sclerosis.
Brain : a journal of neurology
Deshaies JE,Shkreta L,Moszczynski AJ,Sidibé H,Semmler S,Fouillen A,Bennett ER,Bekenstein U,Destroismaisons L,Toutant J,Delmotte Q,Volkening K,Stabile S,Aulas A,Khalfallah Y,Soreq H,Nanci A,Strong MJ,Chabot B,Vande Velde C
Tue May 01 00:00:00 UTC 2018
TDP-43 regulates the alternative splicing of hnRNP A1 to yield an aggregation-prone variant in amyotrophic lateral sclerosis.
Brain : a journal of neurology
Deshaies JE,Shkreta L,Moszczynski AJ,Sidibé H,Semmler S,Fouillen A,Bennett ER,Bekenstein U,Destroismaisons L,Toutant J,Delmotte Q,Volkening K,Stabile S,Aulas A,Khalfallah Y,Soreq H,Nanci A,Strong MJ,Chabot B,Vande Velde C
Tue May 01 00:00:00 UTC 2018
A proteomic network approach across the ALS-FTD disease spectrum resolves clinical phenotypes and genetic vulnerability in human brain.
EMBO molecular medicine
Umoh ME,Dammer EB,Dai J,Duong DM,Lah JJ,Levey AI,Gearing M,Glass JD,Seyfried NT
Mon Jan 01 00:00:00 UTC 2018
A proteomic network approach across the ALS-FTD disease spectrum resolves clinical phenotypes and genetic vulnerability in human brain.
EMBO molecular medicine
Umoh ME,Dammer EB,Dai J,Duong DM,Lah JJ,Levey AI,Gearing M,Glass JD,Seyfried NT
Mon Jan 01 00:00:00 UTC 2018
A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing.
The EMBO journal
Wang A,Conicella AE,Schmidt HB,Martin EW,Rhoads SN,Reeb AN,Nourse A,Ramirez Montero D,Ryan VH,Rohatgi R,Shewmaker F,Naik MT,Mittag T,Ayala YM,Fawzi NL
Thu Mar 01 00:00:00 UTC 2018
A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing.
The EMBO journal
Wang A,Conicella AE,Schmidt HB,Martin EW,Rhoads SN,Reeb AN,Nourse A,Ramirez Montero D,Ryan VH,Rohatgi R,Shewmaker F,Naik MT,Mittag T,Ayala YM,Fawzi NL
Thu Mar 01 00:00:00 UTC 2018
Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis.
The EMBO journal
Fratta P,Sivakumar P,Humphrey J,Lo K,Ricketts T,Oliveira H,Brito-Armas JM,Kalmar B,Ule A,Yu Y,Birsa N,Bodo C,Collins T,Conicella AE,Mejia Maza A,Marrero-Gagliardi A,Stewart M,Mianne J,Corrochano S,Emmett W,Codner G,Groves M,Fukumura R,Gondo Y,Lythgoe M,Pauws E,Peskett E,Stanier P,Teboul L,Hallegger M,Calvo A,Chiò A,Isaacs AM,Fawzi NL,Wang E,Housman DE,Baralle F,Greensmith L,Buratti E,Plagnol V,Fisher EM,Acevedo-Arozena A
Fri Jun 01 00:00:00 UTC 2018
Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis.
The EMBO journal
Fratta P,Sivakumar P,Humphrey J,Lo K,Ricketts T,Oliveira H,Brito-Armas JM,Kalmar B,Ule A,Yu Y,Birsa N,Bodo C,Collins T,Conicella AE,Mejia Maza A,Marrero-Gagliardi A,Stewart M,Mianne J,Corrochano S,Emmett W,Codner G,Groves M,Fukumura R,Gondo Y,Lythgoe M,Pauws E,Peskett E,Stanier P,Teboul L,Hallegger M,Calvo A,Chiò A,Isaacs AM,Fawzi NL,Wang E,Housman DE,Baralle F,Greensmith L,Buratti E,Plagnol V,Fisher EM,Acevedo-Arozena A
Fri Jun 01 00:00:00 UTC 2018
Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis.
The EMBO journal
Fratta P,Sivakumar P,Humphrey J,Lo K,Ricketts T,Oliveira H,Brito-Armas JM,Kalmar B,Ule A,Yu Y,Birsa N,Bodo C,Collins T,Conicella AE,Mejia Maza A,Marrero-Gagliardi A,Stewart M,Mianne J,Corrochano S,Emmett W,Codner G,Groves M,Fukumura R,Gondo Y,Lythgoe M,Pauws E,Peskett E,Stanier P,Teboul L,Hallegger M,Calvo A,Chiò A,Isaacs AM,Fawzi NL,Wang E,Housman DE,Baralle F,Greensmith L,Buratti E,Plagnol V,Fisher EM,Acevedo-Arozena A
Fri Jun 01 00:00:00 UTC 2018
Cryptic exon splicing function of TARDBP interacts with autophagy in nervous tissue.
Autophagy
Torres P,Ramírez-Núñez O,Romero-Guevara R,Barés G,Granado-Serrano AB,Ayala V,Boada J,Fontdevila L,Povedano M,Sanchís D,Pamplona R,Ferrer I,Portero-Otín M
Fri Oct 11 00:00:00 UTC 2019
Mutant UBQLN2 promotes toxicity by modulating intrinsic self-assembly.
Proceedings of the National Academy of Sciences of the United States of America
Sharkey LM,Safren N,Pithadia AS,Gerson JE,Dulchavsky M,Fischer S,Patel R,Lantis G,Ashraf N,Kim JH,Meliki A,Minakawa EN,Barmada SJ,Ivanova MI,Paulson HL
Tue Oct 30 00:00:00 UTC 2018
Mutant UBQLN2 promotes toxicity by modulating intrinsic self-assembly.
Proceedings of the National Academy of Sciences of the United States of America
Sharkey LM,Safren N,Pithadia AS,Gerson JE,Dulchavsky M,Fischer S,Patel R,Lantis G,Ashraf N,Kim JH,Meliki A,Minakawa EN,Barmada SJ,Ivanova MI,Paulson HL
Tue Oct 30 00:00:00 UTC 2018
Alzheimer neuropathology without frontotemporal lobar degeneration hallmarks (TAR DNA-binding protein 43 inclusions) in missense progranulin mutation Cys139Arg.
Brain pathology (Zurich, Switzerland)
Redaelli V,Rossi G,Maderna E,Kovacs GG,Piccoli E,Caroppo P,Cacciatore F,Spinello S,Grisoli M,Sozzi G,Salmaggi A,Tagliavini F,Giaccone G
Mon Jan 01 00:00:00 UTC 2018
Alzheimer neuropathology without frontotemporal lobar degeneration hallmarks (TAR DNA-binding protein 43 inclusions) in missense progranulin mutation Cys139Arg.
Brain pathology (Zurich, Switzerland)
Redaelli V,Rossi G,Maderna E,Kovacs GG,Piccoli E,Caroppo P,Cacciatore F,Spinello S,Grisoli M,Sozzi G,Salmaggi A,Tagliavini F,Giaccone G
Mon Jan 01 00:00:00 UTC 2018
Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Kuliyev E,Gingras S,Guy CS,Howell S,Vogel P,Pelletier S
Wed Mar 07 00:00:00 UTC 2018
Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Kuliyev E,Gingras S,Guy CS,Howell S,Vogel P,Pelletier S
Wed Mar 07 00:00:00 UTC 2018
TDP-43 pathology in multiple system atrophy: colocalization of TDP-43 and α-synuclein in glial cytoplasmic inclusions.
Neuropathology and applied neurobiology
Koga S,Lin WL,Walton RL,Ross OA,Dickson DW
Sat Dec 01 00:00:00 UTC 2018
TDP-43 pathology in multiple system atrophy: colocalization of TDP-43 and α-synuclein in glial cytoplasmic inclusions.
Neuropathology and applied neurobiology
Koga S,Lin WL,Walton RL,Ross OA,Dickson DW
Sat Dec 01 00:00:00 UTC 2018
Enteroviral Infection Leads to Transactive Response DNA-Binding Protein 43 Pathology in Vivo.
The American journal of pathology
Xue YC,Ruller CM,Fung G,Mohamud Y,Deng H,Liu H,Zhang J,Feuer R,Luo H
Sat Dec 01 00:00:00 UTC 2018
Enteroviral Infection Leads to Transactive Response DNA-Binding Protein 43 Pathology in Vivo.
The American journal of pathology
Xue YC,Ruller CM,Fung G,Mohamud Y,Deng H,Liu H,Zhang J,Feuer R,Luo H
Sat Dec 01 00:00:00 UTC 2018
Lymphoblastoid cell lines as a model to understand amyotrophic lateral sclerosis disease mechanisms.
Disease models & mechanisms
Pansarasa O,Bordoni M,Drufuca L,Diamanti L,Sproviero D,Trotti R,Bernuzzi S,La Salvia S,Gagliardi S,Ceroni M,Cereda C
Mon Mar 26 00:00:00 UTC 2018
Lymphoblastoid cell lines as a model to understand amyotrophic lateral sclerosis disease mechanisms.
Disease models & mechanisms
Pansarasa O,Bordoni M,Drufuca L,Diamanti L,Sproviero D,Trotti R,Bernuzzi S,La Salvia S,Gagliardi S,Ceroni M,Cereda C
Mon Mar 26 00:00:00 UTC 2018
Lymphoblastoid cell lines as a model to understand amyotrophic lateral sclerosis disease mechanisms.
Disease models & mechanisms
Pansarasa O,Bordoni M,Drufuca L,Diamanti L,Sproviero D,Trotti R,Bernuzzi S,La Salvia S,Gagliardi S,Ceroni M,Cereda C
Mon Mar 26 00:00:00 UTC 2018
Lymphoblastoid cell lines as a model to understand amyotrophic lateral sclerosis disease mechanisms.
Disease models & mechanisms
Pansarasa O,Bordoni M,Drufuca L,Diamanti L,Sproviero D,Trotti R,Bernuzzi S,La Salvia S,Gagliardi S,Ceroni M,Cereda C
Mon Mar 26 00:00:00 UTC 2018
Angiogenin Prevents Progranulin A9D Mutation-Induced Neuronal-Like Cell Apoptosis Through Cleaving tRNAs into tiRNAs.
Molecular neurobiology
Li S,Chen Y,Sun D,Bai R,Gao X,Yang Y,Sheng J,Xu Z
Thu Feb 01 00:00:00 UTC 2018
Angiogenin Prevents Progranulin A9D Mutation-Induced Neuronal-Like Cell Apoptosis Through Cleaving tRNAs into tiRNAs.
Molecular neurobiology
Li S,Chen Y,Sun D,Bai R,Gao X,Yang Y,Sheng J,Xu Z
Thu Feb 01 00:00:00 UTC 2018
Muscle-dominant wild-type TDP-43 expression induces myopathological changes featuring tubular aggregates and TDP-43-positive inclusions.
Experimental neurology
Tawara N,Yamashita S,Kawakami K,Kurashige T,Zhang Z,Tasaki M,Yamamoto Y,Nishikami T,Doki T,Zhang X,Matsuo Y,Kimura E,Tawara A,Maeda Y,Hauschka SD,Maruyama H,Ando Y
Thu Nov 01 00:00:00 UTC 2018
Muscle-dominant wild-type TDP-43 expression induces myopathological changes featuring tubular aggregates and TDP-43-positive inclusions.
Experimental neurology
Tawara N,Yamashita S,Kawakami K,Kurashige T,Zhang Z,Tasaki M,Yamamoto Y,Nishikami T,Doki T,Zhang X,Matsuo Y,Kimura E,Tawara A,Maeda Y,Hauschka SD,Maruyama H,Ando Y
Thu Nov 01 00:00:00 UTC 2018
Muscle-dominant wild-type TDP-43 expression induces myopathological changes featuring tubular aggregates and TDP-43-positive inclusions.
Experimental neurology
Tawara N,Yamashita S,Kawakami K,Kurashige T,Zhang Z,Tasaki M,Yamamoto Y,Nishikami T,Doki T,Zhang X,Matsuo Y,Kimura E,Tawara A,Maeda Y,Hauschka SD,Maruyama H,Ando Y
Thu Nov 01 00:00:00 UTC 2018
Muscle-dominant wild-type TDP-43 expression induces myopathological changes featuring tubular aggregates and TDP-43-positive inclusions.
Experimental neurology
Tawara N,Yamashita S,Kawakami K,Kurashige T,Zhang Z,Tasaki M,Yamamoto Y,Nishikami T,Doki T,Zhang X,Matsuo Y,Kimura E,Tawara A,Maeda Y,Hauschka SD,Maruyama H,Ando Y
Thu Nov 01 00:00:00 UTC 2018
Neuron-Specific HuR-Deficient Mice Spontaneously Develop Motor Neuron Disease.
Journal of immunology (Baltimore, Md. : 1950)
Sun K,Li X,Chen X,Bai Y,Zhou G,Kokiko-Cochran ON,Lamb B,Hamilton TA,Lin CY,Lee YS,Herjan T
Sun Jul 01 00:00:00 UTC 2018
Neuron-Specific HuR-Deficient Mice Spontaneously Develop Motor Neuron Disease.
Journal of immunology (Baltimore, Md. : 1950)
Sun K,Li X,Chen X,Bai Y,Zhou G,Kokiko-Cochran ON,Lamb B,Hamilton TA,Lin CY,Lee YS,Herjan T
Sun Jul 01 00:00:00 UTC 2018
RNA and Protein Interactors with TDP-43 in Human Spinal-Cord Lysates in Amyotrophic Lateral Sclerosis.
Journal of proteome research
Volkening K,Keller BA,Leystra-Lantz C,Strong MJ
Fri Apr 06 00:00:00 UTC 2018
RNA and Protein Interactors with TDP-43 in Human Spinal-Cord Lysates in Amyotrophic Lateral Sclerosis.
Journal of proteome research
Volkening K,Keller BA,Leystra-Lantz C,Strong MJ
Fri Apr 06 00:00:00 UTC 2018
Mitochondrial abnormalities and disruption of the neuromuscular junction precede the clinical phenotype and motor neuron loss in hFUSWT transgenic mice.
Human molecular genetics
So E,Mitchell JC,Memmi C,Chennell G,Vizcay-Barrena G,Allison L,Shaw CE,Vance C
Thu Feb 01 00:00:00 UTC 2018
Mitochondrial abnormalities and disruption of the neuromuscular junction precede the clinical phenotype and motor neuron loss in hFUSWT transgenic mice.
Human molecular genetics
So E,Mitchell JC,Memmi C,Chennell G,Vizcay-Barrena G,Allison L,Shaw CE,Vance C
Thu Feb 01 00:00:00 UTC 2018
Transactive Response DNA-Binding Protein 43 Abnormalities after Traumatic Brain Injury.
Journal of neurotrauma
Tan XL,Sun M,Brady RD,Liu S,Llanos R,Cheung S,Wright DK,Casillas-Espinosa PM,Sashindranath M,O'Brien TJ,McDonald SJ,Turner BJ,Shultz SR
Fri Aug 10 00:00:00 UTC 2018
Transactive Response DNA-Binding Protein 43 Abnormalities after Traumatic Brain Injury.
Journal of neurotrauma
Tan XL,Sun M,Brady RD,Liu S,Llanos R,Cheung S,Wright DK,Casillas-Espinosa PM,Sashindranath M,O'Brien TJ,McDonald SJ,Turner BJ,Shultz SR
Fri Aug 10 00:00:00 UTC 2018
Repetitive Mild Closed Head Injury Alters Protein Expression and Dendritic Complexity in a Mouse Model.
Journal of neurotrauma
Saykally JN,Ratliff WA,Keeley KL,Pick CG,Mervis RF,Citron BA
Mon Jan 01 00:00:00 UTC 2018
Repetitive Mild Closed Head Injury Alters Protein Expression and Dendritic Complexity in a Mouse Model.
Journal of neurotrauma
Saykally JN,Ratliff WA,Keeley KL,Pick CG,Mervis RF,Citron BA
Mon Jan 01 00:00:00 UTC 2018
Spreading of Tau Pathology in Sporadic Alzheimer's Disease Along Cortico-cortical Top-Down Connections.
Cerebral cortex (New York, N.Y. : 1991)
Braak H,Del Tredici K
Sat Sep 01 00:00:00 UTC 2018
Spreading of Tau Pathology in Sporadic Alzheimer's Disease Along Cortico-cortical Top-Down Connections.
Cerebral cortex (New York, N.Y. : 1991)
Braak H,Del Tredici K
Sat Sep 01 00:00:00 UTC 2018
Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis.
Mobile DNA
Pereira GC,Sanchez L,Schaughency PM,Rubio-Roldán A,Choi JA,Planet E,Batra R,Turelli P,Trono D,Ostrow LW,Ravits J,Kazazian HH,Wheelan SJ,Heras SR,Mayer J,García-Pérez JL,Goodier JL
Thu Oct 05 00:00:00 UTC 2023
Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis.
Mobile DNA
Pereira GC,Sanchez L,Schaughency PM,Rubio-Roldán A,Choi JA,Planet E,Batra R,Turelli P,Trono D,Ostrow LW,Ravits J,Kazazian HH,Wheelan SJ,Heras SR,Mayer J,García-Pérez JL,Goodier JL
Thu Oct 05 00:00:00 UTC 2023
DCTN1 F52L mutation case of Perry syndrome with progressive supranuclear palsy-like tauopathy.
Parkinsonism & related disorders
Honda H,Sasagasako N,Shen C,Shijo M,Hamasaki H,Suzuki SO,Tsuboi Y,Fujii N,Iwaki T
Fri Jun 01 00:00:00 UTC 2018
DCTN1 F52L mutation case of Perry syndrome with progressive supranuclear palsy-like tauopathy.
Parkinsonism & related disorders
Honda H,Sasagasako N,Shen C,Shijo M,Hamasaki H,Suzuki SO,Tsuboi Y,Fujii N,Iwaki T
Fri Jun 01 00:00:00 UTC 2018
Myopathy With SQSTM1 and TIA1 Variants: Clinical and Pathological Features.
Frontiers in neurology
Niu Z,Pontifex CS,Berini S,Hamilton LE,Naddaf E,Wieben E,Aleff RA,Martens K,Gruber A,Engel AG,Pfeffer G,Milone M
Sat Apr 09 00:00:00 UTC 2022
Myopathy With SQSTM1 and TIA1 Variants: Clinical and Pathological Features.
Frontiers in neurology
Niu Z,Pontifex CS,Berini S,Hamilton LE,Naddaf E,Wieben E,Aleff RA,Martens K,Gruber A,Engel AG,Pfeffer G,Milone M
Sat Apr 09 00:00:00 UTC 2022
Protein Phosphatase 1 dephosphorylates TDP-43 and suppresses its function in tau exon 10 inclusion.
FEBS letters
Gu J,Wang W,Miao S,Chen F,Wu F,Hu W,Iqbal K,Gong CX,Liu F
Thu Feb 01 00:00:00 UTC 2018
Protein Phosphatase 1 dephosphorylates TDP-43 and suppresses its function in tau exon 10 inclusion.
FEBS letters
Gu J,Wang W,Miao S,Chen F,Wu F,Hu W,Iqbal K,Gong CX,Liu F
Thu Feb 01 00:00:00 UTC 2018
Epigenetic Changes Associated with the Expression of Amyotrophic Lateral Sclerosis (ALS) Causing Genes.
Neuroscience
Masala A,Sanna S,Esposito S,Rassu M,Galioto M,Zinellu A,Carru C,Carrì MT,Iaccarino C,Crosio C
Mon Oct 15 00:00:00 UTC 2018
Epigenetic Changes Associated with the Expression of Amyotrophic Lateral Sclerosis (ALS) Causing Genes.
Neuroscience
Masala A,Sanna S,Esposito S,Rassu M,Galioto M,Zinellu A,Carru C,Carrì MT,Iaccarino C,Crosio C
Mon Oct 15 00:00:00 UTC 2018
Epigenetic Changes Associated with the Expression of Amyotrophic Lateral Sclerosis (ALS) Causing Genes.
Neuroscience
Masala A,Sanna S,Esposito S,Rassu M,Galioto M,Zinellu A,Carru C,Carrì MT,Iaccarino C,Crosio C
Mon Oct 15 00:00:00 UTC 2018
Epigenetic Changes Associated with the Expression of Amyotrophic Lateral Sclerosis (ALS) Causing Genes.
Neuroscience
Masala A,Sanna S,Esposito S,Rassu M,Galioto M,Zinellu A,Carru C,Carrì MT,Iaccarino C,Crosio C
Mon Oct 15 00:00:00 UTC 2018
FTLD/ALS-linked TDP-43 mutations do not alter TDP-43's ability to self-regulate its expression in Drosophila.
Brain research
Miguel L,Avequin T,Pons M,Frebourg T,Campion D,Lecourtois M
Sat Sep 15 00:00:00 UTC 2018
FTLD/ALS-linked TDP-43 mutations do not alter TDP-43's ability to self-regulate its expression in Drosophila.
Brain research
Miguel L,Avequin T,Pons M,Frebourg T,Campion D,Lecourtois M
Sat Sep 15 00:00:00 UTC 2018
Mutation in the RRM2 domain of TDP-43 in Amyotrophic Lateral Sclerosis with rapid progression associated with ubiquitin positive aggregates in cultured motor neurons.
Amyotrophic lateral sclerosis & frontotemporal degeneration
Maurel C,Madji-Hounoum B,Thepault RA,Marouillat S,Brulard C,Danel-Brunaud V,Camdessanche JP,Blasco H,Corcia P,Andres CR,Vourc'h P
Thu Feb 01 00:00:00 UTC 2018
Mutation in the RRM2 domain of TDP-43 in Amyotrophic Lateral Sclerosis with rapid progression associated with ubiquitin positive aggregates in cultured motor neurons.
Amyotrophic lateral sclerosis & frontotemporal degeneration
Maurel C,Madji-Hounoum B,Thepault RA,Marouillat S,Brulard C,Danel-Brunaud V,Camdessanche JP,Blasco H,Corcia P,Andres CR,Vourc'h P
Thu Feb 01 00:00:00 UTC 2018
Mutation in the RRM2 domain of TDP-43 in Amyotrophic Lateral Sclerosis with rapid progression associated with ubiquitin positive aggregates in cultured motor neurons.
Amyotrophic lateral sclerosis & frontotemporal degeneration
Maurel C,Madji-Hounoum B,Thepault RA,Marouillat S,Brulard C,Danel-Brunaud V,Camdessanche JP,Blasco H,Corcia P,Andres CR,Vourc'h P
Thu Feb 01 00:00:00 UTC 2018
Mutation in the RRM2 domain of TDP-43 in Amyotrophic Lateral Sclerosis with rapid progression associated with ubiquitin positive aggregates in cultured motor neurons.
Amyotrophic lateral sclerosis & frontotemporal degeneration
Maurel C,Madji-Hounoum B,Thepault RA,Marouillat S,Brulard C,Danel-Brunaud V,Camdessanche JP,Blasco H,Corcia P,Andres CR,Vourc'h P
Thu Feb 01 00:00:00 UTC 2018
Primary fibroblasts derived from sporadic amyotrophic lateral sclerosis patients do not show ALS cytological lesions.
Amyotrophic lateral sclerosis & frontotemporal degeneration
Codron P,Cassereau J,Vourc'h P,Veyrat-Durebex C,Blasco H,Kane S,Procaccio V,Letournel F,Verny C,Lenears G,Reynier P,Chevrollier A
Wed Aug 01 00:00:00 UTC 2018
Primary fibroblasts derived from sporadic amyotrophic lateral sclerosis patients do not show ALS cytological lesions.
Amyotrophic lateral sclerosis & frontotemporal degeneration
Codron P,Cassereau J,Vourc'h P,Veyrat-Durebex C,Blasco H,Kane S,Procaccio V,Letournel F,Verny C,Lenears G,Reynier P,Chevrollier A
Wed Aug 01 00:00:00 UTC 2018
Analysis of endocannabinoid receptors and enzymes in the post-mortem motor cortex and spinal cord of amyotrophic lateral sclerosis patients.
Amyotrophic lateral sclerosis & frontotemporal degeneration
Espejo-Porras F,Fernández-Ruiz J,de Lago E
Wed Aug 01 00:00:00 UTC 2018
Analysis of endocannabinoid receptors and enzymes in the post-mortem motor cortex and spinal cord of amyotrophic lateral sclerosis patients.
Amyotrophic lateral sclerosis & frontotemporal degeneration
Espejo-Porras F,Fernández-Ruiz J,de Lago E
Wed Aug 01 00:00:00 UTC 2018
Transcription-Dependent Formation of Nuclear Granules Containing FUS and RNA Pol II.
Biochemistry
Thompson VF,Victor RA,Morera AA,Moinpour M,Liu MN,Kisiel CC,Pickrel K,Springhower CE,Schwartz JC
Wed Dec 26 00:00:00 UTC 2018
Transcription-Dependent Formation of Nuclear Granules Containing FUS and RNA Pol II.
Biochemistry
Thompson VF,Victor RA,Morera AA,Moinpour M,Liu MN,Kisiel CC,Pickrel K,Springhower CE,Schwartz JC
Wed Dec 26 00:00:00 UTC 2018
Behavioral defects in a DCTN1G71A transgenic mouse model of Perry syndrome.
Neuroscience letters
Mishima T,Deshimaru M,Watanabe T,Kubota K,Kinoshita-Kawada M,Yuasa-Kawada J,Takasaki K,Uehara Y,Jinno S,Iwasaki K,Tsuboi Y
Wed Feb 14 00:00:00 UTC 2018
Behavioral defects in a DCTN1G71A transgenic mouse model of Perry syndrome.
Neuroscience letters
Mishima T,Deshimaru M,Watanabe T,Kubota K,Kinoshita-Kawada M,Yuasa-Kawada J,Takasaki K,Uehara Y,Jinno S,Iwasaki K,Tsuboi Y
Wed Feb 14 00:00:00 UTC 2018
Anterior Cingulate Cortex TDP-43 Pathology in Sporadic Amyotrophic Lateral Sclerosis.
Journal of neuropathology and experimental neurology
Braak H,Del Tredici K
Mon Jan 01 00:00:00 UTC 2018
Anterior Cingulate Cortex TDP-43 Pathology in Sporadic Amyotrophic Lateral Sclerosis.
Journal of neuropathology and experimental neurology
Braak H,Del Tredici K
Mon Jan 01 00:00:00 UTC 2018
Multiple Proteinopathies in Familial ALS Cases With Optineurin Mutations.
Journal of neuropathology and experimental neurology
Ayaki T,Ito H,Komure O,Kamada M,Nakamura M,Wate R,Kusaka H,Yamaguchi Y,Li F,Kawakami H,Urushitani M,Takahashi R
Thu Feb 01 00:00:00 UTC 2018
Multiple Proteinopathies in Familial ALS Cases With Optineurin Mutations.
Journal of neuropathology and experimental neurology
Ayaki T,Ito H,Komure O,Kamada M,Nakamura M,Wate R,Kusaka H,Yamaguchi Y,Li F,Kawakami H,Urushitani M,Takahashi R
Thu Feb 01 00:00:00 UTC 2018
Essential role of hippocampal noradrenaline in the regulation of spatial working memory and TDP-43 tissue pathology.
The Journal of comparative neurology
Pintus R,Riggi M,Cannarozzo C,Valeri A,de Leo G,Romano M,Gulino R,Leanza G
Tue May 01 00:00:00 UTC 2018
Essential role of hippocampal noradrenaline in the regulation of spatial working memory and TDP-43 tissue pathology.
The Journal of comparative neurology
Pintus R,Riggi M,Cannarozzo C,Valeri A,de Leo G,Romano M,Gulino R,Leanza G
Tue May 01 00:00:00 UTC 2018
Potentiating Hsp104 activity via phosphomimetic mutations in the middle domain.
FEMS yeast research
Tariq A,Lin J,Noll MM,Torrente MP,Mack KL,Murillo OH,Jackrel ME,Shorter J
Wed Aug 01 00:00:00 UTC 2018
Potentiating Hsp104 activity via phosphomimetic mutations in the middle domain.
FEMS yeast research
Tariq A,Lin J,Noll MM,Torrente MP,Mack KL,Murillo OH,Jackrel ME,Shorter J
Wed Aug 01 00:00:00 UTC 2018
Potentiating Hsp104 activity via phosphomimetic mutations in the middle domain.
FEMS yeast research
Tariq A,Lin J,Noll MM,Torrente MP,Mack KL,Murillo OH,Jackrel ME,Shorter J
Wed Aug 01 00:00:00 UTC 2018
Potentiating Hsp104 activity via phosphomimetic mutations in the middle domain.
FEMS yeast research
Tariq A,Lin J,Noll MM,Torrente MP,Mack KL,Murillo OH,Jackrel ME,Shorter J
Wed Aug 01 00:00:00 UTC 2018
Frontotemporal dementia with trans-activation response DNA-binding protein 43 presenting with catatonic syndrome.
Neuropathology : official journal of the Japanese Society of Neuropathology
Watanabe R,Kawakami I,Onaya M,Higashi S,Arai N,Akiyama H,Hasegawa M,Arai T
Fri Jun 01 00:00:00 UTC 2018
Frontotemporal dementia with trans-activation response DNA-binding protein 43 presenting with catatonic syndrome.
Neuropathology : official journal of the Japanese Society of Neuropathology
Watanabe R,Kawakami I,Onaya M,Higashi S,Arai N,Akiyama H,Hasegawa M,Arai T
Fri Jun 01 00:00:00 UTC 2018
Motor neuron differentiation of iPSCs obtained from peripheral blood of a mutant TARDBP ALS patient.
Stem cell research
Bossolasco P,Sassone F,Gumina V,Peverelli S,Garzo M,Silani V
Sun Jul 01 00:00:00 UTC 2018
Motor neuron differentiation of iPSCs obtained from peripheral blood of a mutant TARDBP ALS patient.
Stem cell research
Bossolasco P,Sassone F,Gumina V,Peverelli S,Garzo M,Silani V
Sun Jul 01 00:00:00 UTC 2018
Identification of TCERG1 as a new genetic modulator of TDP-43 production in Drosophila.
Acta neuropathologica communications
Pons M,Prieto S,Miguel L,Frebourg T,Campion D,Suñé C,Lecourtois M
Wed Dec 12 00:00:00 UTC 2018
Identification of TCERG1 as a new genetic modulator of TDP-43 production in Drosophila.
Acta neuropathologica communications
Pons M,Prieto S,Miguel L,Frebourg T,Campion D,Suñé C,Lecourtois M
Wed Dec 12 00:00:00 UTC 2018
CHCHD10 mutations p.R15L and p.G66V cause motoneuron disease by haploinsufficiency.
Human molecular genetics
Brockmann SJ,Freischmidt A,Oeckl P,Müller K,Ponna SK,Helferich AM,Paone C,Reinders J,Kojer K,Orth M,Jokela M,Auranen M,Udd B,Hermann A,Danzer KM,Lichtner P,Walther P,Ludolph AC,Andersen PM,Otto M,Kursula P,Just S,Weishaupt JH
Thu Feb 15 00:00:00 UTC 2018
Phosphorylated TDP-43 (pTDP-43) aggregates in the axial skeletal muscle of patients with sporadic and familial amyotrophic lateral sclerosis.
Acta neuropathologica communications
Cykowski MD,Powell SZ,Appel JW,Arumanayagam AS,Rivera AL,Appel SH
Fri Apr 13 00:00:00 UTC 2018
Phosphorylated TDP-43 (pTDP-43) aggregates in the axial skeletal muscle of patients with sporadic and familial amyotrophic lateral sclerosis.
Acta neuropathologica communications
Cykowski MD,Powell SZ,Appel JW,Arumanayagam AS,Rivera AL,Appel SH
Fri Apr 13 00:00:00 UTC 2018
Neurodegenerative Disease Proteinopathies Are Connected to Distinct Histone Post-translational Modification Landscapes.
ACS chemical neuroscience
Chen K,Bennett SA,Rana N,Yousuf H,Said M,Taaseen S,Mendo N,Meltser SM,Torrente MP
Wed Apr 18 00:00:00 UTC 2018
Neurodegenerative Disease Proteinopathies Are Connected to Distinct Histone Post-translational Modification Landscapes.
ACS chemical neuroscience
Chen K,Bennett SA,Rana N,Yousuf H,Said M,Taaseen S,Mendo N,Meltser SM,Torrente MP
Wed Apr 18 00:00:00 UTC 2018
Methods to Investigate the Molecular Basis of Progranulin Actions on Brain and Behavior In Vivo Using Knockout Mice.
Methods in molecular biology (Clifton, N.J.)
Boddaert J,Wils H,Kumar-Singh S
Mon Mar 04 00:00:00 UTC 2019
Methods to Investigate the Molecular Basis of Progranulin Actions on Brain and Behavior In Vivo Using Knockout Mice.
Methods in molecular biology (Clifton, N.J.)
Boddaert J,Wils H,Kumar-Singh S
Mon Mar 04 00:00:00 UTC 2019
Methods to Investigate the Molecular Basis of Progranulin Actions on Brain and Behavior In Vivo Using Knockout Mice.
Methods in molecular biology (Clifton, N.J.)
Boddaert J,Wils H,Kumar-Singh S
Mon Mar 04 00:00:00 UTC 2019
Methods to Investigate the Molecular Basis of Progranulin Actions on Brain and Behavior In Vivo Using Knockout Mice.
Methods in molecular biology (Clifton, N.J.)
Boddaert J,Wils H,Kumar-Singh S
Mon Mar 04 00:00:00 UTC 2019
Cerebral ischemia induces the aggregation of proteins linked to neurodegenerative diseases.
Scientific reports
Kahl A,Blanco I,Jackman K,Baskar J,Milaganur Mohan H,Rodney-Sandy R,Zhang S,Iadecola C,Hochrainer K
Fri Feb 09 00:00:00 UTC 2018
Cerebral ischemia induces the aggregation of proteins linked to neurodegenerative diseases.
Scientific reports
Kahl A,Blanco I,Jackman K,Baskar J,Milaganur Mohan H,Rodney-Sandy R,Zhang S,Iadecola C,Hochrainer K
Fri Feb 09 00:00:00 UTC 2018
Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay.
Proceedings of the National Academy of Sciences of the United States of America
Nguyen AD,Nguyen TA,Zhang J,Devireddy S,Zhou P,Karydas AM,Xu X,Miller BL,Rigo F,Ferguson SM,Huang EJ,Walther TC,Farese RV
Tue Mar 20 00:00:00 UTC 2018
Identification and characterization of ubiquitinylation sites in TAR DNA-binding protein of 43 kDa (TDP-43).
The Journal of biological chemistry
Hans F,Eckert M,von Zweydorf F,Gloeckner CJ,Kahle PJ
Fri Oct 12 00:00:00 UTC 2018
Identification and characterization of ubiquitinylation sites in TAR DNA-binding protein of 43 kDa (TDP-43).
The Journal of biological chemistry
Hans F,Eckert M,von Zweydorf F,Gloeckner CJ,Kahle PJ
Fri Oct 12 00:00:00 UTC 2018
Identification and characterization of ubiquitinylation sites in TAR DNA-binding protein of 43 kDa (TDP-43).
The Journal of biological chemistry
Hans F,Eckert M,von Zweydorf F,Gloeckner CJ,Kahle PJ
Fri Oct 12 00:00:00 UTC 2018
Identification and characterization of ubiquitinylation sites in TAR DNA-binding protein of 43 kDa (TDP-43).
The Journal of biological chemistry
Hans F,Eckert M,von Zweydorf F,Gloeckner CJ,Kahle PJ
Fri Oct 12 00:00:00 UTC 2018
Mutant UBQLN2P497H in motor neurons leads to ALS-like phenotypes and defective autophagy in rats.
Acta neuropathologica communications
Chen T,Huang B,Shi X,Gao L,Huang C
Thu Nov 08 00:00:00 UTC 2018
Mutant UBQLN2P497H in motor neurons leads to ALS-like phenotypes and defective autophagy in rats.
Acta neuropathologica communications
Chen T,Huang B,Shi X,Gao L,Huang C
Thu Nov 08 00:00:00 UTC 2018
TDP43 nuclear export and neurodegeneration in models of amyotrophic lateral sclerosis and frontotemporal dementia.
Scientific reports
Archbold HC,Jackson KL,Arora A,Weskamp K,Tank EM,Li X,Miguez R,Dayton RD,Tamir S,Klein RL,Barmada SJ
Thu Mar 15 00:00:00 UTC 2018
TDP43 nuclear export and neurodegeneration in models of amyotrophic lateral sclerosis and frontotemporal dementia.
Scientific reports
Archbold HC,Jackson KL,Arora A,Weskamp K,Tank EM,Li X,Miguez R,Dayton RD,Tamir S,Klein RL,Barmada SJ
Thu Mar 15 00:00:00 UTC 2018
TDP43 nuclear export and neurodegeneration in models of amyotrophic lateral sclerosis and frontotemporal dementia.
Scientific reports
Archbold HC,Jackson KL,Arora A,Weskamp K,Tank EM,Li X,Miguez R,Dayton RD,Tamir S,Klein RL,Barmada SJ
Thu Mar 15 00:00:00 UTC 2018
TDP43 nuclear export and neurodegeneration in models of amyotrophic lateral sclerosis and frontotemporal dementia.
Scientific reports
Archbold HC,Jackson KL,Arora A,Weskamp K,Tank EM,Li X,Miguez R,Dayton RD,Tamir S,Klein RL,Barmada SJ
Thu Mar 15 00:00:00 UTC 2018
The age of onset and evolution of Braak tangle stage and Thal amyloid pathology of Alzheimer's disease in individuals with Down syndrome.
Acta neuropathologica communications
Davidson YS,Robinson A,Prasher VP,Mann DMA
Wed Jul 04 00:00:00 UTC 2018
The age of onset and evolution of Braak tangle stage and Thal amyloid pathology of Alzheimer's disease in individuals with Down syndrome.
Acta neuropathologica communications
Davidson YS,Robinson A,Prasher VP,Mann DMA
Wed Jul 04 00:00:00 UTC 2018
Characterization of Dopaminergic System in the Striatum of Young Adult Park2-/- Knockout Rats.
Scientific reports
Gemechu JM,Sharma A,Yu D,Xie Y,Merkel OM,Moszczynska A
Wed Jan 24 00:00:00 UTC 2018
Characterization of Dopaminergic System in the Striatum of Young Adult Park2-/- Knockout Rats.
Scientific reports
Gemechu JM,Sharma A,Yu D,Xie Y,Merkel OM,Moszczynska A
Wed Jan 24 00:00:00 UTC 2018
Characterization of Dopaminergic System in the Striatum of Young Adult Park2-/- Knockout Rats.
Scientific reports
Gemechu JM,Sharma A,Yu D,Xie Y,Merkel OM,Moszczynska A
Wed Jan 24 00:00:00 UTC 2018
Characterization of Dopaminergic System in the Striatum of Young Adult Park2-/- Knockout Rats.
Scientific reports
Gemechu JM,Sharma A,Yu D,Xie Y,Merkel OM,Moszczynska A
Wed Jan 24 00:00:00 UTC 2018
DGCR8 Promotes Neural Progenitor Expansion and Represses Neurogenesis in the Mouse Embryonic Neocortex.
Frontiers in neuroscience
Hoffmann N,Weise SC,Marinaro F,Vogel T,De Pietri Tonelli D
Thu Oct 01 00:00:00 UTC 2020
DGCR8 Promotes Neural Progenitor Expansion and Represses Neurogenesis in the Mouse Embryonic Neocortex.
Frontiers in neuroscience
Hoffmann N,Weise SC,Marinaro F,Vogel T,De Pietri Tonelli D
Thu Oct 01 00:00:00 UTC 2020
TDP-43 regulation of stress granule dynamics in neurodegenerative disease-relevant cell types.
Scientific reports
Khalfallah Y,Kuta R,Grasmuck C,Prat A,Durham HD,Vande Velde C
Tue May 15 00:00:00 UTC 2018
TDP-43 regulation of stress granule dynamics in neurodegenerative disease-relevant cell types.
Scientific reports
Khalfallah Y,Kuta R,Grasmuck C,Prat A,Durham HD,Vande Velde C
Tue May 15 00:00:00 UTC 2018
TDP-43 regulation of stress granule dynamics in neurodegenerative disease-relevant cell types.
Scientific reports
Khalfallah Y,Kuta R,Grasmuck C,Prat A,Durham HD,Vande Velde C
Tue May 15 00:00:00 UTC 2018
TDP-43 regulation of stress granule dynamics in neurodegenerative disease-relevant cell types.
Scientific reports
Khalfallah Y,Kuta R,Grasmuck C,Prat A,Durham HD,Vande Velde C
Tue May 15 00:00:00 UTC 2018
TAR DNA-Binding Protein 43 and Disrupted in Schizophrenia 1 Coaggregation Disrupts Dendritic Local Translation and Mental Function in Frontotemporal Lobar Degeneration.
Biological psychiatry
Endo R,Takashima N,Nekooki-Machida Y,Komi Y,Hui KK,Takao M,Akatsu H,Murayama S,Sawa A,Tanaka M
Mon Oct 01 00:00:00 UTC 2018
Towards a TDP-43-Based Biomarker for ALS and FTLD.
Molecular neurobiology
Feneberg E,Gray E,Ansorge O,Talbot K,Turner MR
Mon Oct 01 00:00:00 UTC 2018
Citrullination of RGG Motifs in FET Proteins by PAD4 Regulates Protein Aggregation and ALS Susceptibility.
Cell reports
Tanikawa C,Ueda K,Suzuki A,Iida A,Nakamura R,Atsuta N,Tohnai G,Sobue G,Saichi N,Momozawa Y,Kamatani Y,Kubo M,Yamamoto K,Nakamura Y,Matsuda K
Tue Feb 06 00:00:00 UTC 2018
Citrullination of RGG Motifs in FET Proteins by PAD4 Regulates Protein Aggregation and ALS Susceptibility.
Cell reports
Tanikawa C,Ueda K,Suzuki A,Iida A,Nakamura R,Atsuta N,Tohnai G,Sobue G,Saichi N,Momozawa Y,Kamatani Y,Kubo M,Yamamoto K,Nakamura Y,Matsuda K
Tue Feb 06 00:00:00 UTC 2018
Subarachnoid hemorrhage enhances the expression of TDP-43 in the brain of experimental rats and human subjects.
Experimental and therapeutic medicine
He T,Zuo Y,Ai-Zakwani K,Luo J,Zhu H,Yan XX,Liu F
Mon Oct 01 00:00:00 UTC 2018
Subarachnoid hemorrhage enhances the expression of TDP-43 in the brain of experimental rats and human subjects.
Experimental and therapeutic medicine
He T,Zuo Y,Ai-Zakwani K,Luo J,Zhu H,Yan XX,Liu F
Mon Oct 01 00:00:00 UTC 2018
Subarachnoid hemorrhage enhances the expression of TDP-43 in the brain of experimental rats and human subjects.
Experimental and therapeutic medicine
He T,Zuo Y,Ai-Zakwani K,Luo J,Zhu H,Yan XX,Liu F
Mon Oct 01 00:00:00 UTC 2018
Subarachnoid hemorrhage enhances the expression of TDP-43 in the brain of experimental rats and human subjects.
Experimental and therapeutic medicine
He T,Zuo Y,Ai-Zakwani K,Luo J,Zhu H,Yan XX,Liu F
Mon Oct 01 00:00:00 UTC 2018
Subarachnoid hemorrhage enhances the expression of TDP-43 in the brain of experimental rats and human subjects.
Experimental and therapeutic medicine
He T,Zuo Y,Ai-Zakwani K,Luo J,Zhu H,Yan XX,Liu F
Mon Oct 01 00:00:00 UTC 2018
Subarachnoid hemorrhage enhances the expression of TDP-43 in the brain of experimental rats and human subjects.
Experimental and therapeutic medicine
He T,Zuo Y,Ai-Zakwani K,Luo J,Zhu H,Yan XX,Liu F
Mon Oct 01 00:00:00 UTC 2018
Dichotomous scoring of TDP-43 proteinopathy from specific brain regions in 27 academic research centers: associations with Alzheimer's disease and cerebrovascular disease pathologies.
Acta neuropathologica communications
Katsumata Y,Fardo DW,Kukull WA,Nelson PT
Wed Dec 19 00:00:00 UTC 2018
Dichotomous scoring of TDP-43 proteinopathy from specific brain regions in 27 academic research centers: associations with Alzheimer's disease and cerebrovascular disease pathologies.
Acta neuropathologica communications
Katsumata Y,Fardo DW,Kukull WA,Nelson PT
Wed Dec 19 00:00:00 UTC 2018
Dichotomous scoring of TDP-43 proteinopathy from specific brain regions in 27 academic research centers: associations with Alzheimer's disease and cerebrovascular disease pathologies.
Acta neuropathologica communications
Katsumata Y,Fardo DW,Kukull WA,Nelson PT
Wed Dec 19 00:00:00 UTC 2018
Dichotomous scoring of TDP-43 proteinopathy from specific brain regions in 27 academic research centers: associations with Alzheimer's disease and cerebrovascular disease pathologies.
Acta neuropathologica communications
Katsumata Y,Fardo DW,Kukull WA,Nelson PT
Wed Dec 19 00:00:00 UTC 2018
Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization.
Scientific reports
Pinarbasi ES,Cağatay T,Fung HYJ,Li YC,Chook YM,Thomas PJ
Fri May 04 00:00:00 UTC 2018
Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization.
Scientific reports
Pinarbasi ES,Cağatay T,Fung HYJ,Li YC,Chook YM,Thomas PJ
Fri May 04 00:00:00 UTC 2018
Disruption by SaCas9 Endonuclease of HERV-Kenv, a Retroviral Gene with Oncogenic and Neuropathogenic Potential, Inhibits Molecules Involved in Cancer and Amyotrophic Lateral Sclerosis.
Viruses
Ibba G,Piu C,Uleri E,Serra C,Dolei A
Tue Aug 07 00:00:00 UTC 2018
Disruption by SaCas9 Endonuclease of HERV-Kenv, a Retroviral Gene with Oncogenic and Neuropathogenic Potential, Inhibits Molecules Involved in Cancer and Amyotrophic Lateral Sclerosis.
Viruses
Ibba G,Piu C,Uleri E,Serra C,Dolei A
Tue Aug 07 00:00:00 UTC 2018
mTh1 driven expression of hTDP-43 results in typical ALS/FTLD neuropathological symptoms.
PloS one
Scherz B,Rabl R,Flunkert S,Rohler S,Neddens J,Taub N,Temmel M,Panzenboeck U,Niederkofler V,Zimmermann R,Hutter-Paier B
Mon Nov 26 00:00:00 UTC 2018
mTh1 driven expression of hTDP-43 results in typical ALS/FTLD neuropathological symptoms.
PloS one
Scherz B,Rabl R,Flunkert S,Rohler S,Neddens J,Taub N,Temmel M,Panzenboeck U,Niederkofler V,Zimmermann R,Hutter-Paier B
Mon Nov 26 00:00:00 UTC 2018
mTh1 driven expression of hTDP-43 results in typical ALS/FTLD neuropathological symptoms.
PloS one
Scherz B,Rabl R,Flunkert S,Rohler S,Neddens J,Taub N,Temmel M,Panzenboeck U,Niederkofler V,Zimmermann R,Hutter-Paier B
Mon Nov 26 00:00:00 UTC 2018
mTh1 driven expression of hTDP-43 results in typical ALS/FTLD neuropathological symptoms.
PloS one
Scherz B,Rabl R,Flunkert S,Rohler S,Neddens J,Taub N,Temmel M,Panzenboeck U,Niederkofler V,Zimmermann R,Hutter-Paier B
Mon Nov 26 00:00:00 UTC 2018
Mutation-dependent aggregation and toxicity in a Drosophila model for UBQLN2-associated ALS.
Human molecular genetics
Kim SH,Stiles SG,Feichtmeier JM,Ramesh N,Zhan L,Scalf MA,Smith LM,Pandey UB,Tibbetts RS
Mon Jan 15 00:00:00 UTC 2018
Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism.
eLife
Conlon EG,Fagegaltier D,Agius P,Davis-Porada J,Gregory J,Hubbard I,Kang K,Kim D,Phatnani H,Shneider NA,Manley JL
Fri Jul 13 00:00:00 UTC 2018
Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism.
eLife
Conlon EG,Fagegaltier D,Agius P,Davis-Porada J,Gregory J,Hubbard I,Kang K,Kim D,Phatnani H,Shneider NA,Manley JL
Fri Jul 13 00:00:00 UTC 2018
Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration.
Nature communications
Paul S,Dansithong W,Figueroa KP,Scoles DR,Pulst SM
Fri Sep 07 00:00:00 UTC 2018
Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration.
Nature communications
Paul S,Dansithong W,Figueroa KP,Scoles DR,Pulst SM
Fri Sep 07 00:00:00 UTC 2018
A patient with posterior cortical atrophy due to Alzheimer's disease.
Dementia & neuropsychologia
de Souza RKM,Grinberg LT,Josviak ND,de Almeida DB,Ramina R,Kowacs PA,Caramelli P
Wed Sep 30 00:00:00 UTC 2020
Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity.
Nature communications
Chung CY,Berson A,Kennerdell JR,Sartoris A,Unger T,Porta S,Kim HJ,Smith ER,Shilatifard A,Van Deerlin V,Lee VM,Chen-Plotkin A,Bonini NM
Tue Oct 23 00:00:00 UTC 2018
Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity.
Nature communications
Chung CY,Berson A,Kennerdell JR,Sartoris A,Unger T,Porta S,Kim HJ,Smith ER,Shilatifard A,Van Deerlin V,Lee VM,Chen-Plotkin A,Bonini NM
Tue Oct 23 00:00:00 UTC 2018
Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice.
Molecular neurodegeneration
Beel S,Herdewyn S,Fazal R,De Decker M,Moisse M,Robberecht W,Van Den Bosch L,Van Damme P
Tue Oct 16 00:00:00 UTC 2018
Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice.
Molecular neurodegeneration
Beel S,Herdewyn S,Fazal R,De Decker M,Moisse M,Robberecht W,Van Den Bosch L,Van Damme P
Tue Oct 16 00:00:00 UTC 2018
Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis.
Molecular neurodegeneration
Shelkovnikova TA,Kukharsky MS,An H,Dimasi P,Alexeeva S,Shabir O,Heath PR,Buchman VL
Fri Jun 01 00:00:00 UTC 2018
Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis.
Molecular neurodegeneration
Shelkovnikova TA,Kukharsky MS,An H,Dimasi P,Alexeeva S,Shabir O,Heath PR,Buchman VL
Fri Jun 01 00:00:00 UTC 2018
Colocalization of Bunina bodies and TDP-43 inclusions in a case of sporadic amyotrophic lateral sclerosis with Lewy body-like hyaline inclusions.
Neuropathology : official journal of the Japanese Society of Neuropathology
Miki Y,Mori F,Seino Y,Tanji K,Yoshizawa T,Kijima H,Shoji M,Wakabayashi K
Mon Oct 01 00:00:00 UTC 2018
Colocalization of Bunina bodies and TDP-43 inclusions in a case of sporadic amyotrophic lateral sclerosis with Lewy body-like hyaline inclusions.
Neuropathology : official journal of the Japanese Society of Neuropathology
Miki Y,Mori F,Seino Y,Tanji K,Yoshizawa T,Kijima H,Shoji M,Wakabayashi K
Mon Oct 01 00:00:00 UTC 2018
Selective Spatiotemporal Vulnerability of Central Nervous System Neurons to Pathologic TAR DNA-Binding Protein 43 in Aged Transgenic Mice.
The American journal of pathology
van Hummel A,Chan G,van der Hoven J,Morsch M,Ippati S,Suh L,Bi M,Asih PR,Lee WS,Butler TA,Przybyla M,Halliday GM,Piguet O,Kiernan MC,Chung RS,Ittner LM,Ke YD
Fri Jun 01 00:00:00 UTC 2018
Selective Spatiotemporal Vulnerability of Central Nervous System Neurons to Pathologic TAR DNA-Binding Protein 43 in Aged Transgenic Mice.
The American journal of pathology
van Hummel A,Chan G,van der Hoven J,Morsch M,Ippati S,Suh L,Bi M,Asih PR,Lee WS,Butler TA,Przybyla M,Halliday GM,Piguet O,Kiernan MC,Chung RS,Ittner LM,Ke YD
Fri Jun 01 00:00:00 UTC 2018
Accumulation of poly(A) RNA in nuclear granules enriched in Sam68 in motor neurons from the SMNΔ7 mouse model of SMA.
Scientific reports
Narcís JO,Tapia O,Tarabal O,Piedrafita L,Calderó J,Berciano MT,Lafarga M
Mon Jun 25 00:00:00 UTC 2018
Accumulation of poly(A) RNA in nuclear granules enriched in Sam68 in motor neurons from the SMNΔ7 mouse model of SMA.
Scientific reports
Narcís JO,Tapia O,Tarabal O,Piedrafita L,Calderó J,Berciano MT,Lafarga M
Mon Jun 25 00:00:00 UTC 2018
Age-related deregulation of TDP-43 after stroke enhances NF-κB-mediated inflammation and neuronal damage.
Journal of neuroinflammation
Thammisetty SS,Pedragosa J,Weng YC,Calon F,Planas A,Kriz J
Fri Nov 09 00:00:00 UTC 2018
Age-related deregulation of TDP-43 after stroke enhances NF-κB-mediated inflammation and neuronal damage.
Journal of neuroinflammation
Thammisetty SS,Pedragosa J,Weng YC,Calon F,Planas A,Kriz J
Fri Nov 09 00:00:00 UTC 2018
Age-related deregulation of TDP-43 after stroke enhances NF-κB-mediated inflammation and neuronal damage.
Journal of neuroinflammation
Thammisetty SS,Pedragosa J,Weng YC,Calon F,Planas A,Kriz J
Fri Nov 09 00:00:00 UTC 2018
Age-related deregulation of TDP-43 after stroke enhances NF-κB-mediated inflammation and neuronal damage.
Journal of neuroinflammation
Thammisetty SS,Pedragosa J,Weng YC,Calon F,Planas A,Kriz J
Fri Nov 09 00:00:00 UTC 2018
Age-related deregulation of TDP-43 after stroke enhances NF-κB-mediated inflammation and neuronal damage.
Journal of neuroinflammation
Thammisetty SS,Pedragosa J,Weng YC,Calon F,Planas A,Kriz J
Fri Nov 09 00:00:00 UTC 2018
Distinct multilevel misregulations of Parkin and PINK1 revealed in cell and animal models of TDP-43 proteinopathy.
Cell death & disease
Sun X,Duan Y,Qin C,Li JC,Duan G,Deng X,Ni J,Cao X,Xiang K,Tian K,Chen CH,Li A,Fang Y
Thu Sep 20 00:00:00 UTC 2018
Distinct multilevel misregulations of Parkin and PINK1 revealed in cell and animal models of TDP-43 proteinopathy.
Cell death & disease
Sun X,Duan Y,Qin C,Li JC,Duan G,Deng X,Ni J,Cao X,Xiang K,Tian K,Chen CH,Li A,Fang Y
Thu Sep 20 00:00:00 UTC 2018
Angiopoietin-1 and ανβ3 integrin peptide promote the therapeutic effects of L-serine in an amyotrophic lateral sclerosis/Parkinsonism dementia complex model.
Aging
Cai HY,Tian KW,Zhang YY,Jiang H,Han S
Sun Nov 25 00:00:00 UTC 2018
Angiopoietin-1 and ανβ3 integrin peptide promote the therapeutic effects of L-serine in an amyotrophic lateral sclerosis/Parkinsonism dementia complex model.
Aging
Cai HY,Tian KW,Zhang YY,Jiang H,Han S
Sun Nov 25 00:00:00 UTC 2018
Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4.
Nature
Skrott Z,Mistrik M,Andersen KK,Friis S,Majera D,Gursky J,Ozdian T,Bartkova J,Turi Z,Moudry P,Kraus M,Michalova M,Vaclavkova J,Dzubak P,Vrobel I,Pouckova P,Sedlacek J,Miklovicova A,Kutt A,Li J,Mattova J,Driessen C,Dou QP,Olsen J,Hajduch M,Cvek B,Deshaies RJ,Bartek J
Thu Dec 14 00:00:00 UTC 2017
Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4.
Nature
Skrott Z,Mistrik M,Andersen KK,Friis S,Majera D,Gursky J,Ozdian T,Bartkova J,Turi Z,Moudry P,Kraus M,Michalova M,Vaclavkova J,Dzubak P,Vrobel I,Pouckova P,Sedlacek J,Miklovicova A,Kutt A,Li J,Mattova J,Driessen C,Dou QP,Olsen J,Hajduch M,Cvek B,Deshaies RJ,Bartek J
Thu Dec 14 00:00:00 UTC 2017
Major hnRNP proteins act as general TDP-43 functional modifiers both in Drosophila and human neuronal cells.
Nucleic acids research
Appocher C,Mohagheghi F,Cappelli S,Stuani C,Romano M,Feiguin F,Buratti E
Thu Jul 27 00:00:00 UTC 2017
Major hnRNP proteins act as general TDP-43 functional modifiers both in Drosophila and human neuronal cells.
Nucleic acids research
Appocher C,Mohagheghi F,Cappelli S,Stuani C,Romano M,Feiguin F,Buratti E
Thu Jul 27 00:00:00 UTC 2017
Major hnRNP proteins act as general TDP-43 functional modifiers both in Drosophila and human neuronal cells.
Nucleic acids research
Appocher C,Mohagheghi F,Cappelli S,Stuani C,Romano M,Feiguin F,Buratti E
Thu Jul 27 00:00:00 UTC 2017
Major hnRNP proteins act as general TDP-43 functional modifiers both in Drosophila and human neuronal cells.
Nucleic acids research
Appocher C,Mohagheghi F,Cappelli S,Stuani C,Romano M,Feiguin F,Buratti E
Thu Jul 27 00:00:00 UTC 2017
Nuclear poly(A) binding protein 1 (PABPN1) and Matrin3 interact in muscle cells and regulate RNA processing.
Nucleic acids research
Banerjee A,Vest KE,Pavlath GK,Corbett AH
Fri Oct 13 00:00:00 UTC 2017
Nuclear poly(A) binding protein 1 (PABPN1) and Matrin3 interact in muscle cells and regulate RNA processing.
Nucleic acids research
Banerjee A,Vest KE,Pavlath GK,Corbett AH
Fri Oct 13 00:00:00 UTC 2017
TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss.
Neuron
Paolicelli RC,Jawaid A,Henstridge CM,Valeri A,Merlini M,Robinson JL,Lee EB,Rose J,Appel S,Lee VM,Trojanowski JQ,Spires-Jones T,Schulz PE,Rajendran L
Wed Jul 19 00:00:00 UTC 2017
TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss.
Neuron
Paolicelli RC,Jawaid A,Henstridge CM,Valeri A,Merlini M,Robinson JL,Lee EB,Rose J,Appel S,Lee VM,Trojanowski JQ,Spires-Jones T,Schulz PE,Rajendran L
Wed Jul 19 00:00:00 UTC 2017
TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss.
Neuron
Paolicelli RC,Jawaid A,Henstridge CM,Valeri A,Merlini M,Robinson JL,Lee EB,Rose J,Appel S,Lee VM,Trojanowski JQ,Spires-Jones T,Schulz PE,Rajendran L
Wed Jul 19 00:00:00 UTC 2017
TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss.
Neuron
Paolicelli RC,Jawaid A,Henstridge CM,Valeri A,Merlini M,Robinson JL,Lee EB,Rose J,Appel S,Lee VM,Trojanowski JQ,Spires-Jones T,Schulz PE,Rajendran L
Wed Jul 19 00:00:00 UTC 2017
Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31.
Neuron
Ishiguro T,Sato N,Ueyama M,Fujikake N,Sellier C,Kanegami A,Tokuda E,Zamiri B,Gall-Duncan T,Mirceta M,Furukawa Y,Yokota T,Wada K,Taylor JP,Pearson CE,Charlet-Berguerand N,Mizusawa H,Nagai Y,Ishikawa K
Wed Apr 05 00:00:00 UTC 2017
Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31.
Neuron
Ishiguro T,Sato N,Ueyama M,Fujikake N,Sellier C,Kanegami A,Tokuda E,Zamiri B,Gall-Duncan T,Mirceta M,Furukawa Y,Yokota T,Wada K,Taylor JP,Pearson CE,Charlet-Berguerand N,Mizusawa H,Nagai Y,Ishikawa K
Wed Apr 05 00:00:00 UTC 2017
Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31.
Neuron
Ishiguro T,Sato N,Ueyama M,Fujikake N,Sellier C,Kanegami A,Tokuda E,Zamiri B,Gall-Duncan T,Mirceta M,Furukawa Y,Yokota T,Wada K,Taylor JP,Pearson CE,Charlet-Berguerand N,Mizusawa H,Nagai Y,Ishikawa K
Wed Apr 05 00:00:00 UTC 2017
Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31.
Neuron
Ishiguro T,Sato N,Ueyama M,Fujikake N,Sellier C,Kanegami A,Tokuda E,Zamiri B,Gall-Duncan T,Mirceta M,Furukawa Y,Yokota T,Wada K,Taylor JP,Pearson CE,Charlet-Berguerand N,Mizusawa H,Nagai Y,Ishikawa K
Wed Apr 05 00:00:00 UTC 2017
TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics.
Neuron
Mackenzie IR,Nicholson AM,Sarkar M,Messing J,Purice MD,Pottier C,Annu K,Baker M,Perkerson RB,Kurti A,Matchett BJ,Mittag T,Temirov J,Hsiung GR,Krieger C,Murray ME,Kato M,Fryer JD,Petrucelli L,Zinman L,Weintraub S,Mesulam M,Keith J,Zivkovic SA,Hirsch-Reinshagen V,Roos RP,Züchner S,Graff-Radford NR,Petersen RC,Caselli RJ,Wszolek ZK,Finger E,Lippa C,Lacomis D,Stewart H,Dickson DW,Kim HJ,Rogaeva E,Bigio E,Boylan KB,Taylor JP,Rademakers R
Wed Aug 16 00:00:00 UTC 2017
TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics.
Neuron
Mackenzie IR,Nicholson AM,Sarkar M,Messing J,Purice MD,Pottier C,Annu K,Baker M,Perkerson RB,Kurti A,Matchett BJ,Mittag T,Temirov J,Hsiung GR,Krieger C,Murray ME,Kato M,Fryer JD,Petrucelli L,Zinman L,Weintraub S,Mesulam M,Keith J,Zivkovic SA,Hirsch-Reinshagen V,Roos RP,Züchner S,Graff-Radford NR,Petersen RC,Caselli RJ,Wszolek ZK,Finger E,Lippa C,Lacomis D,Stewart H,Dickson DW,Kim HJ,Rogaeva E,Bigio E,Boylan KB,Taylor JP,Rademakers R
Wed Aug 16 00:00:00 UTC 2017
TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics.
Neuron
Mackenzie IR,Nicholson AM,Sarkar M,Messing J,Purice MD,Pottier C,Annu K,Baker M,Perkerson RB,Kurti A,Matchett BJ,Mittag T,Temirov J,Hsiung GR,Krieger C,Murray ME,Kato M,Fryer JD,Petrucelli L,Zinman L,Weintraub S,Mesulam M,Keith J,Zivkovic SA,Hirsch-Reinshagen V,Roos RP,Züchner S,Graff-Radford NR,Petersen RC,Caselli RJ,Wszolek ZK,Finger E,Lippa C,Lacomis D,Stewart H,Dickson DW,Kim HJ,Rogaeva E,Bigio E,Boylan KB,Taylor JP,Rademakers R
Wed Aug 16 00:00:00 UTC 2017
TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics.
Neuron
Mackenzie IR,Nicholson AM,Sarkar M,Messing J,Purice MD,Pottier C,Annu K,Baker M,Perkerson RB,Kurti A,Matchett BJ,Mittag T,Temirov J,Hsiung GR,Krieger C,Murray ME,Kato M,Fryer JD,Petrucelli L,Zinman L,Weintraub S,Mesulam M,Keith J,Zivkovic SA,Hirsch-Reinshagen V,Roos RP,Züchner S,Graff-Radford NR,Petersen RC,Caselli RJ,Wszolek ZK,Finger E,Lippa C,Lacomis D,Stewart H,Dickson DW,Kim HJ,Rogaeva E,Bigio E,Boylan KB,Taylor JP,Rademakers R
Wed Aug 16 00:00:00 UTC 2017
TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics.
Neuron
Mackenzie IR,Nicholson AM,Sarkar M,Messing J,Purice MD,Pottier C,Annu K,Baker M,Perkerson RB,Kurti A,Matchett BJ,Mittag T,Temirov J,Hsiung GR,Krieger C,Murray ME,Kato M,Fryer JD,Petrucelli L,Zinman L,Weintraub S,Mesulam M,Keith J,Zivkovic SA,Hirsch-Reinshagen V,Roos RP,Züchner S,Graff-Radford NR,Petersen RC,Caselli RJ,Wszolek ZK,Finger E,Lippa C,Lacomis D,Stewart H,Dickson DW,Kim HJ,Rogaeva E,Bigio E,Boylan KB,Taylor JP,Rademakers R
Wed Aug 16 00:00:00 UTC 2017
Incipient progressive supranuclear palsy is more common than expected and may comprise clinicopathological subtypes: a forensic autopsy series.
Acta neuropathologica
Yoshida K,Hata Y,Kinoshita K,Takashima S,Tanaka K,Nishida N
Mon May 01 00:00:00 UTC 2017
Incipient progressive supranuclear palsy is more common than expected and may comprise clinicopathological subtypes: a forensic autopsy series.
Acta neuropathologica
Yoshida K,Hata Y,Kinoshita K,Takashima S,Tanaka K,Nishida N
Mon May 01 00:00:00 UTC 2017
Misfolded SOD1 is not a primary component of sporadic ALS.
Acta neuropathologica
Da Cruz S,Bui A,Saberi S,Lee SK,Stauffer J,McAlonis-Downes M,Schulte D,Pizzo DP,Parone PA,Cleveland DW,Ravits J
Sat Jul 01 00:00:00 UTC 2017
Misfolded SOD1 is not a primary component of sporadic ALS.
Acta neuropathologica
Da Cruz S,Bui A,Saberi S,Lee SK,Stauffer J,McAlonis-Downes M,Schulte D,Pizzo DP,Parone PA,Cleveland DW,Ravits J
Sat Jul 01 00:00:00 UTC 2017
Cryptic exon incorporation occurs in Alzheimer's brain lacking TDP-43 inclusion but exhibiting nuclear clearance of TDP-43.
Acta neuropathologica
Sun M,Bell W,LaClair KD,Ling JP,Han H,Kageyama Y,Pletnikova O,Troncoso JC,Wong PC,Chen LL
Thu Jun 01 00:00:00 UTC 2017
Cryptic exon incorporation occurs in Alzheimer's brain lacking TDP-43 inclusion but exhibiting nuclear clearance of TDP-43.
Acta neuropathologica
Sun M,Bell W,LaClair KD,Ling JP,Han H,Kageyama Y,Pletnikova O,Troncoso JC,Wong PC,Chen LL
Thu Jun 01 00:00:00 UTC 2017
Cryptic exon incorporation occurs in Alzheimer's brain lacking TDP-43 inclusion but exhibiting nuclear clearance of TDP-43.
Acta neuropathologica
Sun M,Bell W,LaClair KD,Ling JP,Han H,Kageyama Y,Pletnikova O,Troncoso JC,Wong PC,Chen LL
Thu Jun 01 00:00:00 UTC 2017
Pathological TDP-43 changes in Betz cells differ from those in bulbar and spinal α-motoneurons in sporadic amyotrophic lateral sclerosis.
Acta neuropathologica
Braak H,Ludolph AC,Neumann M,Ravits J,Del Tredici K
Sun Jan 01 00:00:00 UTC 2017
Pathological TDP-43 changes in Betz cells differ from those in bulbar and spinal α-motoneurons in sporadic amyotrophic lateral sclerosis.
Acta neuropathologica
Braak H,Ludolph AC,Neumann M,Ravits J,Del Tredici K
Sun Jan 01 00:00:00 UTC 2017
Expansion of the classification of FTLD-TDP: distinct pathology associated with rapidly progressive frontotemporal degeneration.
Acta neuropathologica
Lee EB,Porta S,Michael Baer G,Xu Y,Suh E,Kwong LK,Elman L,Grossman M,Lee VM,Irwin DJ,Van Deerlin VM,Trojanowski JQ
Sat Jul 01 00:00:00 UTC 2017
Expansion of the classification of FTLD-TDP: distinct pathology associated with rapidly progressive frontotemporal degeneration.
Acta neuropathologica
Lee EB,Porta S,Michael Baer G,Xu Y,Suh E,Kwong LK,Elman L,Grossman M,Lee VM,Irwin DJ,Van Deerlin VM,Trojanowski JQ
Sat Jul 01 00:00:00 UTC 2017
Motor-Coordinative and Cognitive Dysfunction Caused by Mutant TDP-43 Could Be Reversed by Inhibiting Its Mitochondrial Localization.
Molecular therapy : the journal of the American Society of Gene Therapy
Wang W,Arakawa H,Wang L,Okolo O,Siedlak SL,Jiang Y,Gao J,Xie F,Petersen RB,Wang X
Wed Jan 04 00:00:00 UTC 2017
Motor-Coordinative and Cognitive Dysfunction Caused by Mutant TDP-43 Could Be Reversed by Inhibiting Its Mitochondrial Localization.
Molecular therapy : the journal of the American Society of Gene Therapy
Wang W,Arakawa H,Wang L,Okolo O,Siedlak SL,Jiang Y,Gao J,Xie F,Petersen RB,Wang X
Wed Jan 04 00:00:00 UTC 2017
Motor-Coordinative and Cognitive Dysfunction Caused by Mutant TDP-43 Could Be Reversed by Inhibiting Its Mitochondrial Localization.
Molecular therapy : the journal of the American Society of Gene Therapy
Wang W,Arakawa H,Wang L,Okolo O,Siedlak SL,Jiang Y,Gao J,Xie F,Petersen RB,Wang X
Wed Jan 04 00:00:00 UTC 2017
Motor-Coordinative and Cognitive Dysfunction Caused by Mutant TDP-43 Could Be Reversed by Inhibiting Its Mitochondrial Localization.
Molecular therapy : the journal of the American Society of Gene Therapy
Wang W,Arakawa H,Wang L,Okolo O,Siedlak SL,Jiang Y,Gao J,Xie F,Petersen RB,Wang X
Wed Jan 04 00:00:00 UTC 2017
Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like TDP-43 RNP granules in neurons.
Proceedings of the National Academy of Sciences of the United States of America
Gopal PP,Nirschl JJ,Klinman E,Holzbaur EL
Tue Mar 21 00:00:00 UTC 2017
Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like TDP-43 RNP granules in neurons.
Proceedings of the National Academy of Sciences of the United States of America
Gopal PP,Nirschl JJ,Klinman E,Holzbaur EL
Tue Mar 21 00:00:00 UTC 2017
Neuropathological diagnoses and clinical correlates in older adults in Brazil: A cross-sectional study.
PLoS medicine
Suemoto CK,Ferretti-Rebustini RE,Rodriguez RD,Leite RE,Soterio L,Brucki SM,Spera RR,Cippiciani TM,Farfel JM,Chiavegatto Filho A,Naslavsky MS,Zatz M,Pasqualucci CA,Jacob-Filho W,Nitrini R,Grinberg LT
Wed Mar 01 00:00:00 UTC 2017
Neuropathological diagnoses and clinical correlates in older adults in Brazil: A cross-sectional study.
PLoS medicine
Suemoto CK,Ferretti-Rebustini RE,Rodriguez RD,Leite RE,Soterio L,Brucki SM,Spera RR,Cippiciani TM,Farfel JM,Chiavegatto Filho A,Naslavsky MS,Zatz M,Pasqualucci CA,Jacob-Filho W,Nitrini R,Grinberg LT
Wed Mar 01 00:00:00 UTC 2017
Pathological correlations of [F-18]-AV-1451 imaging in non-alzheimer tauopathies.
Annals of neurology
Marquié M,Normandin MD,Meltzer AC,Siao Tick Chong M,Andrea NV,Antón-Fernández A,Klunk WE,Mathis CA,Ikonomovic MD,Debnath M,Bien EA,Vanderburg CR,Costantino I,Makaretz S,DeVos SL,Oakley DH,Gomperts SN,Growdon JH,Domoto-Reilly K,Lucente D,Dickerson BC,Frosch MP,Hyman BT,Johnson KA,Gómez-Isla T
Sun Jan 01 00:00:00 UTC 2017
Pathological correlations of [F-18]-AV-1451 imaging in non-alzheimer tauopathies.
Annals of neurology
Marquié M,Normandin MD,Meltzer AC,Siao Tick Chong M,Andrea NV,Antón-Fernández A,Klunk WE,Mathis CA,Ikonomovic MD,Debnath M,Bien EA,Vanderburg CR,Costantino I,Makaretz S,DeVos SL,Oakley DH,Gomperts SN,Growdon JH,Domoto-Reilly K,Lucente D,Dickerson BC,Frosch MP,Hyman BT,Johnson KA,Gómez-Isla T
Sun Jan 01 00:00:00 UTC 2017
A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Cell systems
Seyfried NT,Dammer EB,Swarup V,Nandakumar D,Duong DM,Yin L,Deng Q,Nguyen T,Hales CM,Wingo T,Glass J,Gearing M,Thambisetty M,Troncoso JC,Geschwind DH,Lah JJ,Levey AI
Wed Jan 25 00:00:00 UTC 2017
TDP-43 Promotes Neurodegeneration by Impairing Chromatin Remodeling.
Current biology : CB
Berson A,Sartoris A,Nativio R,Van Deerlin V,Toledo JB,Porta S,Liu S,Chung CY,Garcia BA,Lee VM,Trojanowski JQ,Johnson FB,Berger SL,Bonini NM
Mon Dec 04 00:00:00 UTC 2017
TDP-43 Promotes Neurodegeneration by Impairing Chromatin Remodeling.
Current biology : CB
Berson A,Sartoris A,Nativio R,Van Deerlin V,Toledo JB,Porta S,Liu S,Chung CY,Garcia BA,Lee VM,Trojanowski JQ,Johnson FB,Berger SL,Bonini NM
Mon Dec 04 00:00:00 UTC 2017
TDP-43 Promotes Neurodegeneration by Impairing Chromatin Remodeling.
Current biology : CB
Berson A,Sartoris A,Nativio R,Van Deerlin V,Toledo JB,Porta S,Liu S,Chung CY,Garcia BA,Lee VM,Trojanowski JQ,Johnson FB,Berger SL,Bonini NM
Mon Dec 04 00:00:00 UTC 2017
TDP-43 Promotes Neurodegeneration by Impairing Chromatin Remodeling.
Current biology : CB
Berson A,Sartoris A,Nativio R,Van Deerlin V,Toledo JB,Porta S,Liu S,Chung CY,Garcia BA,Lee VM,Trojanowski JQ,Johnson FB,Berger SL,Bonini NM
Mon Dec 04 00:00:00 UTC 2017
TDP-43 Promotes Neurodegeneration by Impairing Chromatin Remodeling.
Current biology : CB
Berson A,Sartoris A,Nativio R,Van Deerlin V,Toledo JB,Porta S,Liu S,Chung CY,Garcia BA,Lee VM,Trojanowski JQ,Johnson FB,Berger SL,Bonini NM
Mon Dec 04 00:00:00 UTC 2017
TDP-43 Promotes Neurodegeneration by Impairing Chromatin Remodeling.
Current biology : CB
Berson A,Sartoris A,Nativio R,Van Deerlin V,Toledo JB,Porta S,Liu S,Chung CY,Garcia BA,Lee VM,Trojanowski JQ,Johnson FB,Berger SL,Bonini NM
Mon Dec 04 00:00:00 UTC 2017
Imaging specific newly synthesized proteins within cells by fluorescence resonance energy transfer.
Chemical science
Sheng L,Cai L,Liu J,Zhang S,Xu JJ,Zhang X,Chen HY
Sun Jan 01 00:00:00 UTC 2017
Imaging specific newly synthesized proteins within cells by fluorescence resonance energy transfer.
Chemical science
Sheng L,Cai L,Liu J,Zhang S,Xu JJ,Zhang X,Chen HY
Sun Jan 01 00:00:00 UTC 2017
TDP-43 expression influences amyloidβ plaque deposition and tau aggregation.
Neurobiology of disease
Davis SA,Gan KA,Dowell JA,Cairns NJ,Gitcho MA
Sat Jul 01 00:00:00 UTC 2017
TDP-43 expression influences amyloidβ plaque deposition and tau aggregation.
Neurobiology of disease
Davis SA,Gan KA,Dowell JA,Cairns NJ,Gitcho MA
Sat Jul 01 00:00:00 UTC 2017
TDP-43 expression influences amyloidβ plaque deposition and tau aggregation.
Neurobiology of disease
Davis SA,Gan KA,Dowell JA,Cairns NJ,Gitcho MA
Sat Jul 01 00:00:00 UTC 2017
TDP-43 expression influences amyloidβ plaque deposition and tau aggregation.
Neurobiology of disease
Davis SA,Gan KA,Dowell JA,Cairns NJ,Gitcho MA
Sat Jul 01 00:00:00 UTC 2017
Calpain-Dependent Degradation of Nucleoporins Contributes to Motor Neuron Death in a Mouse Model of Chronic Excitotoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sugiyama K,Aida T,Nomura M,Takayanagi R,Zeilhofer HU,Tanaka K
Wed Sep 06 00:00:00 UTC 2017
Calpain-Dependent Degradation of Nucleoporins Contributes to Motor Neuron Death in a Mouse Model of Chronic Excitotoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sugiyama K,Aida T,Nomura M,Takayanagi R,Zeilhofer HU,Tanaka K
Wed Sep 06 00:00:00 UTC 2017
Calpain-Dependent Degradation of Nucleoporins Contributes to Motor Neuron Death in a Mouse Model of Chronic Excitotoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sugiyama K,Aida T,Nomura M,Takayanagi R,Zeilhofer HU,Tanaka K
Wed Sep 06 00:00:00 UTC 2017
Calpain-Dependent Degradation of Nucleoporins Contributes to Motor Neuron Death in a Mouse Model of Chronic Excitotoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sugiyama K,Aida T,Nomura M,Takayanagi R,Zeilhofer HU,Tanaka K
Wed Sep 06 00:00:00 UTC 2017
Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro.
Frontiers in molecular neuroscience
Wobst HJ,Wesolowski SS,Chadchankar J,Delsing L,Jacobsen S,Mukherjee J,Deeb TZ,Dunlop J,Brandon NJ,Moss SJ
Tue Nov 15 00:00:00 UTC 2022
Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro.
Frontiers in molecular neuroscience
Wobst HJ,Wesolowski SS,Chadchankar J,Delsing L,Jacobsen S,Mukherjee J,Deeb TZ,Dunlop J,Brandon NJ,Moss SJ
Tue Nov 15 00:00:00 UTC 2022
Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro.
Frontiers in molecular neuroscience
Wobst HJ,Wesolowski SS,Chadchankar J,Delsing L,Jacobsen S,Mukherjee J,Deeb TZ,Dunlop J,Brandon NJ,Moss SJ
Tue Nov 15 00:00:00 UTC 2022
Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro.
Frontiers in molecular neuroscience
Wobst HJ,Wesolowski SS,Chadchankar J,Delsing L,Jacobsen S,Mukherjee J,Deeb TZ,Dunlop J,Brandon NJ,Moss SJ
Tue Nov 15 00:00:00 UTC 2022
Decreased Levels of Foldase and Chaperone Proteins Are Associated with an Early-Onset Amyotrophic Lateral Sclerosis.
Frontiers in molecular neuroscience
Filareti M,Luotti S,Pasetto L,Pignataro M,Paolella K,Messina P,Pupillo E,Filosto M,Lunetta C,Mandrioli J,Fuda G,Calvo A,Chiò A,Corbo M,Bendotti C,Beghi E,Bonetto V
Thu Oct 01 00:00:00 UTC 2020
Decreased Levels of Foldase and Chaperone Proteins Are Associated with an Early-Onset Amyotrophic Lateral Sclerosis.
Frontiers in molecular neuroscience
Filareti M,Luotti S,Pasetto L,Pignataro M,Paolella K,Messina P,Pupillo E,Filosto M,Lunetta C,Mandrioli J,Fuda G,Calvo A,Chiò A,Corbo M,Bendotti C,Beghi E,Bonetto V
Thu Oct 01 00:00:00 UTC 2020
Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.
Disease models & mechanisms
Cho KI,Yoon D,Qiu S,Danziger Z,Grill WM,Wetsel WC,Ferreira PA
Mon May 01 00:00:00 UTC 2017
Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.
Disease models & mechanisms
Cho KI,Yoon D,Qiu S,Danziger Z,Grill WM,Wetsel WC,Ferreira PA
Mon May 01 00:00:00 UTC 2017
Enhancing Mitofusin/Marf ameliorates neuromuscular dysfunction in Drosophila models of TDP-43 proteinopathies.
Neurobiology of aging
Khalil B,Cabirol-Pol MJ,Miguel L,Whitworth AJ,Lecourtois M,Liévens JC
Thu Jun 01 00:00:00 UTC 2017
Enhancing Mitofusin/Marf ameliorates neuromuscular dysfunction in Drosophila models of TDP-43 proteinopathies.
Neurobiology of aging
Khalil B,Cabirol-Pol MJ,Miguel L,Whitworth AJ,Lecourtois M,Liévens JC
Thu Jun 01 00:00:00 UTC 2017
Dysregulation of chromatin remodelling complexes in amyotrophic lateral sclerosis.
Human molecular genetics
Tibshirani M,Zhao B,Gentil BJ,Minotti S,Marques C,Keith J,Rogaeva E,Zinman L,Rouaux C,Robertson J,Durham HD
Wed Nov 01 00:00:00 UTC 2017
Dysregulation of chromatin remodelling complexes in amyotrophic lateral sclerosis.
Human molecular genetics
Tibshirani M,Zhao B,Gentil BJ,Minotti S,Marques C,Keith J,Rogaeva E,Zinman L,Rouaux C,Robertson J,Durham HD
Wed Nov 01 00:00:00 UTC 2017
C9ORF72 hexanucleotide repeat exerts toxicity in a stable, inducible motor neuronal cell model, which is rescued by partial depletion of Pten.
Human molecular genetics
Stopford MJ,Higginbottom A,Hautbergue GM,Cooper-Knock J,Mulcahy PJ,De Vos KJ,Renton AE,Pliner H,Calvo A,Chio A,Traynor BJ,Azzouz M,Heath PR,Kirby J,Shaw PJ
Wed Mar 15 00:00:00 UTC 2017
C9ORF72 hexanucleotide repeat exerts toxicity in a stable, inducible motor neuronal cell model, which is rescued by partial depletion of Pten.
Human molecular genetics
Stopford MJ,Higginbottom A,Hautbergue GM,Cooper-Knock J,Mulcahy PJ,De Vos KJ,Renton AE,Pliner H,Calvo A,Chio A,Traynor BJ,Azzouz M,Heath PR,Kirby J,Shaw PJ
Wed Mar 15 00:00:00 UTC 2017
Splicing factors act as genetic modulators of TDP-43 production in a new autoregulatory TDP-43 Drosophila model.
Human molecular genetics
Pons M,Miguel L,Miel C,Avequin T,Juge F,Frebourg T,Campion D,Lecourtois M
Fri Sep 01 00:00:00 UTC 2017
Traumatic Brain Injury Results in Cellular, Structural and Functional Changes Resembling Motor Neuron Disease.
Cerebral cortex (New York, N.Y. : 1991)
Wright DK,Liu S,van der Poel C,McDonald SJ,Brady RD,Taylor L,Yang L,Gardner AJ,Ordidge R,O'Brien TJ,Johnston LA,Shultz SR
Fri Sep 01 00:00:00 UTC 2017
Traumatic Brain Injury Results in Cellular, Structural and Functional Changes Resembling Motor Neuron Disease.
Cerebral cortex (New York, N.Y. : 1991)
Wright DK,Liu S,van der Poel C,McDonald SJ,Brady RD,Taylor L,Yang L,Gardner AJ,Ordidge R,O'Brien TJ,Johnston LA,Shultz SR
Fri Sep 01 00:00:00 UTC 2017
GPNMB ameliorates mutant TDP-43-induced motor neuron cell death.
Journal of neuroscience research
Nagahara Y,Shimazawa M,Ohuchi K,Ito J,Takahashi H,Tsuruma K,Kakita A,Hara H
Tue Aug 01 00:00:00 UTC 2017
GPNMB ameliorates mutant TDP-43-induced motor neuron cell death.
Journal of neuroscience research
Nagahara Y,Shimazawa M,Ohuchi K,Ito J,Takahashi H,Tsuruma K,Kakita A,Hara H
Tue Aug 01 00:00:00 UTC 2017
An intronic variation in SLC52A1 causes exon skipping and transient riboflavin-responsive multiple acyl-CoA dehydrogenation deficiency.
Molecular genetics and metabolism
Mosegaard S,Bruun GH,Flyvbjerg KF,Bliksrud YT,Gregersen N,Dembic M,Annexstad E,Tangeraas T,Olsen RKJ,Andresen BS
Fri Dec 01 00:00:00 UTC 2017
An intronic variation in SLC52A1 causes exon skipping and transient riboflavin-responsive multiple acyl-CoA dehydrogenation deficiency.
Molecular genetics and metabolism
Mosegaard S,Bruun GH,Flyvbjerg KF,Bliksrud YT,Gregersen N,Dembic M,Annexstad E,Tangeraas T,Olsen RKJ,Andresen BS
Fri Dec 01 00:00:00 UTC 2017
Microglial and Neuronal TDP-43 Pathology in Anti-IgLON5-Related Tauopathy.
Journal of Alzheimer's disease : JAD
Cagnin A,Mariotto S,Fiorini M,Gaule M,Bonetto N,Tagliapietra M,Buratti E,Zanusso G,Ferrari S,Monaco S
Fri Apr 06 00:00:00 UTC 2018
Microglial and Neuronal TDP-43 Pathology in Anti-IgLON5-Related Tauopathy.
Journal of Alzheimer's disease : JAD
Cagnin A,Mariotto S,Fiorini M,Gaule M,Bonetto N,Tagliapietra M,Buratti E,Zanusso G,Ferrari S,Monaco S
Fri Apr 06 00:00:00 UTC 2018
Microglial and Neuronal TDP-43 Pathology in Anti-IgLON5-Related Tauopathy.
Journal of Alzheimer's disease : JAD
Cagnin A,Mariotto S,Fiorini M,Gaule M,Bonetto N,Tagliapietra M,Buratti E,Zanusso G,Ferrari S,Monaco S
Fri Apr 06 00:00:00 UTC 2018
Microglial and Neuronal TDP-43 Pathology in Anti-IgLON5-Related Tauopathy.
Journal of Alzheimer's disease : JAD
Cagnin A,Mariotto S,Fiorini M,Gaule M,Bonetto N,Tagliapietra M,Buratti E,Zanusso G,Ferrari S,Monaco S
Fri Apr 06 00:00:00 UTC 2018
Diabetes is Not Associated with Alzheimer's Disease Neuropathology.
Journal of Alzheimer's disease : JAD
Dos Santos Matioli MNP,Suemoto CK,Rodriguez RD,Farias DS,da Silva MM,Leite REP,Ferretti-Rebustini REL,Farfel JM,Pasqualucci CA,Jacob Filho W,Arvanitakis Z,Naslavsky MS,Zatz M,Grinberg LT,Nitrini R
Wed May 30 00:00:00 UTC 2018
Diabetes is Not Associated with Alzheimer's Disease Neuropathology.
Journal of Alzheimer's disease : JAD
Dos Santos Matioli MNP,Suemoto CK,Rodriguez RD,Farias DS,da Silva MM,Leite REP,Ferretti-Rebustini REL,Farfel JM,Pasqualucci CA,Jacob Filho W,Arvanitakis Z,Naslavsky MS,Zatz M,Grinberg LT,Nitrini R
Wed May 30 00:00:00 UTC 2018
Tau Rather than TDP-43 Proteins are Potential Cerebrospinal Fluid Biomarkers for Frontotemporal Lobar Degeneration Subtypes: A Pilot Study.
Journal of Alzheimer's disease : JAD
Kuiperij HB,Versleijen AA,Beenes M,Verwey NA,Benussi L,Paterlini A,Binetti G,Teunissen CE,Raaphorst J,Schelhaas HJ,Küsters B,Pijnenburg YA,Ghidoni R,Verbeek MM
Thu Feb 22 00:00:00 UTC 2018
Tau Rather than TDP-43 Proteins are Potential Cerebrospinal Fluid Biomarkers for Frontotemporal Lobar Degeneration Subtypes: A Pilot Study.
Journal of Alzheimer's disease : JAD
Kuiperij HB,Versleijen AA,Beenes M,Verwey NA,Benussi L,Paterlini A,Binetti G,Teunissen CE,Raaphorst J,Schelhaas HJ,Küsters B,Pijnenburg YA,Ghidoni R,Verbeek MM
Thu Feb 22 00:00:00 UTC 2018
The Effect of Different Types of Nanoparticles on FUS and TDP-43 Solubility and Subcellular Localization.
Neurotoxicity research
Lojk J,Prpar Mihevc S,Bregar VB,Pavlin M,Rogelj B
Sun Oct 01 00:00:00 UTC 2017
The Effect of Different Types of Nanoparticles on FUS and TDP-43 Solubility and Subcellular Localization.
Neurotoxicity research
Lojk J,Prpar Mihevc S,Bregar VB,Pavlin M,Rogelj B
Sun Oct 01 00:00:00 UTC 2017
The Effect of Different Types of Nanoparticles on FUS and TDP-43 Solubility and Subcellular Localization.
Neurotoxicity research
Lojk J,Prpar Mihevc S,Bregar VB,Pavlin M,Rogelj B
Sun Oct 01 00:00:00 UTC 2017
The Effect of Different Types of Nanoparticles on FUS and TDP-43 Solubility and Subcellular Localization.
Neurotoxicity research
Lojk J,Prpar Mihevc S,Bregar VB,Pavlin M,Rogelj B
Sun Oct 01 00:00:00 UTC 2017
Dcp1a and GW182 Induce Distinct Cellular Aggregates and Have Different Effects on microRNA Pathway.
DNA and cell biology
Wang X,Chang L,Wang H,Su A,Wu Z
Sat Jul 01 00:00:00 UTC 2017
Dcp1a and GW182 Induce Distinct Cellular Aggregates and Have Different Effects on microRNA Pathway.
DNA and cell biology
Wang X,Chang L,Wang H,Su A,Wu Z
Sat Jul 01 00:00:00 UTC 2017
TDP-43 proteolysis is associated with astrocyte reactivity after traumatic brain injury in rodents.
Journal of neuroimmunology
Huang CY,Lee YC,Li PC,Liliang PC,Lu K,Wang KW,Chang LC,Shiu LY,Chen MF,Sun YT,Wang HK
Fri Dec 15 00:00:00 UTC 2017
TDP-43 proteolysis is associated with astrocyte reactivity after traumatic brain injury in rodents.
Journal of neuroimmunology
Huang CY,Lee YC,Li PC,Liliang PC,Lu K,Wang KW,Chang LC,Shiu LY,Chen MF,Sun YT,Wang HK
Fri Dec 15 00:00:00 UTC 2017
Perry Syndrome: A Distinctive Type of TDP-43 Proteinopathy.
Journal of neuropathology and experimental neurology
Mishima T,Koga S,Lin WL,Kasanuki K,Castanedes-Casey M,Wszolek ZK,Oh SJ,Tsuboi Y,Dickson DW
Tue Aug 01 00:00:00 UTC 2017
Perry Syndrome: A Distinctive Type of TDP-43 Proteinopathy.
Journal of neuropathology and experimental neurology
Mishima T,Koga S,Lin WL,Kasanuki K,Castanedes-Casey M,Wszolek ZK,Oh SJ,Tsuboi Y,Dickson DW
Tue Aug 01 00:00:00 UTC 2017
Amygdala TDP-43 Pathology in Frontotemporal Lobar Degeneration and Motor Neuron Disease.
Journal of neuropathology and experimental neurology
Takeda T,Seilhean D,Le Ber I,Millecamps S,Sazdovitch V,Kitagawa K,Uchihara T,Duyckaerts C
Fri Sep 01 00:00:00 UTC 2017
Amygdala TDP-43 Pathology in Frontotemporal Lobar Degeneration and Motor Neuron Disease.
Journal of neuropathology and experimental neurology
Takeda T,Seilhean D,Le Ber I,Millecamps S,Sazdovitch V,Kitagawa K,Uchihara T,Duyckaerts C
Fri Sep 01 00:00:00 UTC 2017
Clinical Significance of TDP-43 Neuropathology in Amyotrophic Lateral Sclerosis.
Journal of neuropathology and experimental neurology
Cykowski MD,Powell SZ,Peterson LE,Appel JW,Rivera AL,Takei H,Chang E,Appel SH
Mon May 01 00:00:00 UTC 2017
Clinical Significance of TDP-43 Neuropathology in Amyotrophic Lateral Sclerosis.
Journal of neuropathology and experimental neurology
Cykowski MD,Powell SZ,Peterson LE,Appel JW,Rivera AL,Takei H,Chang E,Appel SH
Mon May 01 00:00:00 UTC 2017
Pathologic Involvement of Glutamatergic Striatal Inputs From the Cortices in TAR DNA-Binding Protein 43 kDa-Related Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis.
Journal of neuropathology and experimental neurology
Riku Y,Watanabe H,Yoshida M,Mimuro M,Iwasaki Y,Masuda M,Ishigaki S,Katsuno M,Sobue G
Fri Sep 01 00:00:00 UTC 2017
Pathologic Involvement of Glutamatergic Striatal Inputs From the Cortices in TAR DNA-Binding Protein 43 kDa-Related Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis.
Journal of neuropathology and experimental neurology
Riku Y,Watanabe H,Yoshida M,Mimuro M,Iwasaki Y,Masuda M,Ishigaki S,Katsuno M,Sobue G
Fri Sep 01 00:00:00 UTC 2017
VEGF alleviates ALS-CSF induced cytoplasmic accumulations of TDP-43 and FUS/TLS in NSC-34 cells.
Journal of chemical neuroanatomy
Shantanu S,Vijayalakshmi K,Shruthi S,Sagar BKC,Sathyaprabha TN,Nalini A,Raju TR,Alladi PA
Sat Apr 01 00:00:00 UTC 2017
VEGF alleviates ALS-CSF induced cytoplasmic accumulations of TDP-43 and FUS/TLS in NSC-34 cells.
Journal of chemical neuroanatomy
Shantanu S,Vijayalakshmi K,Shruthi S,Sagar BKC,Sathyaprabha TN,Nalini A,Raju TR,Alladi PA
Sat Apr 01 00:00:00 UTC 2017
Modelling FUS Mislocalisation in an In Vitro Model of Innervated Human Muscle.
Journal of molecular neuroscience : MN
Prpar Mihevc S,Pavlin M,Darovic S,Živin M,Podbregar M,Rogelj B,Mars T
Tue Aug 01 00:00:00 UTC 2017
Modelling FUS Mislocalisation in an In Vitro Model of Innervated Human Muscle.
Journal of molecular neuroscience : MN
Prpar Mihevc S,Pavlin M,Darovic S,Živin M,Podbregar M,Rogelj B,Mars T
Tue Aug 01 00:00:00 UTC 2017
Imbalanced expression of polycistronic miRNA in acute myeloid leukemia.
International journal of hematology
Kotaki R,Higuchi H,Ogiya D,Katahira Y,Kurosaki N,Yukihira N,Ogata J,Yamamoto H,Mohamad Alba S,Azhim A,Kitajima T,Inoue S,Morishita K,Ono K,Koyama-Nasu R,Kotani A
Fri Dec 01 00:00:00 UTC 2017
Imbalanced expression of polycistronic miRNA in acute myeloid leukemia.
International journal of hematology
Kotaki R,Higuchi H,Ogiya D,Katahira Y,Kurosaki N,Yukihira N,Ogata J,Yamamoto H,Mohamad Alba S,Azhim A,Kitajima T,Inoue S,Morishita K,Ono K,Koyama-Nasu R,Kotani A
Fri Dec 01 00:00:00 UTC 2017
Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS.
Cell reports
Hall CE,Yao Z,Choi M,Tyzack GE,Serio A,Luisier R,Harley J,Preza E,Arber C,Crisp SJ,Watson PMD,Kullmann DM,Abramov AY,Wray S,Burley R,Loh SHY,Martins LM,Stevens MM,Luscombe NM,Sibley CR,Lakatos A,Ule J,Gandhi S,Patani R
Tue May 30 00:00:00 UTC 2017
Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS.
Cell reports
Hall CE,Yao Z,Choi M,Tyzack GE,Serio A,Luisier R,Harley J,Preza E,Arber C,Crisp SJ,Watson PMD,Kullmann DM,Abramov AY,Wray S,Burley R,Loh SHY,Martins LM,Stevens MM,Luscombe NM,Sibley CR,Lakatos A,Ule J,Gandhi S,Patani R
Tue May 30 00:00:00 UTC 2017
Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions.
The Journal of biological chemistry
Mompeán M,Romano V,Pantoja-Uceda D,Stuani C,Baralle FE,Buratti E,Laurents DV
Fri Jul 14 00:00:00 UTC 2017
Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions.
The Journal of biological chemistry
Mompeán M,Romano V,Pantoja-Uceda D,Stuani C,Baralle FE,Buratti E,Laurents DV
Fri Jul 14 00:00:00 UTC 2017
Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions.
The Journal of biological chemistry
Mompeán M,Romano V,Pantoja-Uceda D,Stuani C,Baralle FE,Buratti E,Laurents DV
Fri Jul 14 00:00:00 UTC 2017
Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions.
The Journal of biological chemistry
Mompeán M,Romano V,Pantoja-Uceda D,Stuani C,Baralle FE,Buratti E,Laurents DV
Fri Jul 14 00:00:00 UTC 2017
Clinical and neuropathological features of ALS/FTD with TIA1 mutations.
Acta neuropathologica communications
Hirsch-Reinshagen V,Pottier C,Nicholson AM,Baker M,Hsiung GR,Krieger C,Sengdy P,Boylan KB,Dickson DW,Mesulam M,Weintraub S,Bigio E,Zinman L,Keith J,Rogaeva E,Zivkovic SA,Lacomis D,Taylor JP,Rademakers R,Mackenzie IRA
Thu Dec 07 00:00:00 UTC 2017
Clinical and neuropathological features of ALS/FTD with TIA1 mutations.
Acta neuropathologica communications
Hirsch-Reinshagen V,Pottier C,Nicholson AM,Baker M,Hsiung GR,Krieger C,Sengdy P,Boylan KB,Dickson DW,Mesulam M,Weintraub S,Bigio E,Zinman L,Keith J,Rogaeva E,Zivkovic SA,Lacomis D,Taylor JP,Rademakers R,Mackenzie IRA
Thu Dec 07 00:00:00 UTC 2017
Platelet phosphorylated TDP-43: an exploratory study for a peripheral surrogate biomarker development for Alzheimer's disease.
Future science OA
Wilhite R,Sage JM,Bouzid A,Primavera T,Agbas A
Wed Nov 01 00:00:00 UTC 2017
Platelet phosphorylated TDP-43: an exploratory study for a peripheral surrogate biomarker development for Alzheimer's disease.
Future science OA
Wilhite R,Sage JM,Bouzid A,Primavera T,Agbas A
Wed Nov 01 00:00:00 UTC 2017
Human Endogenous Retrovirus-K and TDP-43 Expression Bridges ALS and HIV Neuropathology.
Frontiers in microbiology
Douville RN,Nath A
Wed Mar 30 00:00:00 UTC 2022
Human Endogenous Retrovirus-K and TDP-43 Expression Bridges ALS and HIV Neuropathology.
Frontiers in microbiology
Douville RN,Nath A
Wed Mar 30 00:00:00 UTC 2022
Total proteome turbidity assay for tracking global protein aggregation in the natural cellular environment.
Journal of biological methods
Shmueli MD,Hizkiahou N,Peled S,Gazit E,Segal D
Tue Sep 29 00:00:00 UTC 2020
Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae.
Nature communications
Albayram O,Kondo A,Mannix R,Smith C,Tsai CY,Li C,Herbert MK,Qiu J,Monuteaux M,Driver J,Yan S,Gormley W,Puccio AM,Okonkwo DO,Lucke-Wold B,Bailes J,Meehan W,Zeidel M,Lu KP,Zhou XZ
Tue Oct 17 00:00:00 UTC 2017
Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae.
Nature communications
Albayram O,Kondo A,Mannix R,Smith C,Tsai CY,Li C,Herbert MK,Qiu J,Monuteaux M,Driver J,Yan S,Gormley W,Puccio AM,Okonkwo DO,Lucke-Wold B,Bailes J,Meehan W,Zeidel M,Lu KP,Zhou XZ
Tue Oct 17 00:00:00 UTC 2017
Novel miR-b2122 regulates several ALS-related RNA-binding proteins.
Molecular brain
Hawley ZCE,Campos-Melo D,Strong MJ
Mon Oct 02 00:00:00 UTC 2017
Novel miR-b2122 regulates several ALS-related RNA-binding proteins.
Molecular brain
Hawley ZCE,Campos-Melo D,Strong MJ
Mon Oct 02 00:00:00 UTC 2017
Multireceptor fingerprints in progressive supranuclear palsy.
Alzheimer's research & therapy
Chiu WZ,Donker Kaat L,Boon AJW,Kamphorst W,Schleicher A,Zilles K,van Swieten JC,Palomero-Gallagher N
Mon Apr 17 00:00:00 UTC 2017
Multireceptor fingerprints in progressive supranuclear palsy.
Alzheimer's research & therapy
Chiu WZ,Donker Kaat L,Boon AJW,Kamphorst W,Schleicher A,Zilles K,van Swieten JC,Palomero-Gallagher N
Mon Apr 17 00:00:00 UTC 2017
Regional correlations between [11C]PIB PET and post-mortem burden of amyloid-beta pathology in a diverse neuropathological cohort.
NeuroImage. Clinical
Seo SW,Ayakta N,Grinberg LT,Villeneuve S,Lehmann M,Reed B,DeCarli C,Miller BL,Rosen HJ,Boxer AL,O'Neil JP,Jin LW,Seeley WW,Jagust WJ,Rabinovici GD
Fri Nov 17 00:00:00 UTC 2017
Regional correlations between [11C]PIB PET and post-mortem burden of amyloid-beta pathology in a diverse neuropathological cohort.
NeuroImage. Clinical
Seo SW,Ayakta N,Grinberg LT,Villeneuve S,Lehmann M,Reed B,DeCarli C,Miller BL,Rosen HJ,Boxer AL,O'Neil JP,Jin LW,Seeley WW,Jagust WJ,Rabinovici GD
Fri Nov 17 00:00:00 UTC 2017
Clusterin protects neurons against intracellular proteotoxicity.
Acta neuropathologica communications
Gregory JM,Whiten DR,Brown RA,Barros TP,Kumita JR,Yerbury JJ,Satapathy S,McDade K,Smith C,Luheshi LM,Dobson CM,Wilson MR
Tue Nov 07 00:00:00 UTC 2017
Clusterin protects neurons against intracellular proteotoxicity.
Acta neuropathologica communications
Gregory JM,Whiten DR,Brown RA,Barros TP,Kumita JR,Yerbury JJ,Satapathy S,McDade K,Smith C,Luheshi LM,Dobson CM,Wilson MR
Tue Nov 07 00:00:00 UTC 2017
Anti-AMPA GluA3 antibodies in Frontotemporal dementia: a new molecular target.
Scientific reports
Borroni B,Stanic J,Verpelli C,Mellone M,Bonomi E,Alberici A,Bernasconi P,Culotta L,Zianni E,Archetti S,Manes M,Gazzina S,Ghidoni R,Benussi L,Stuani C,Di Luca M,Sala C,Buratti E,Padovani A,Gardoni F
Thu Jul 27 00:00:00 UTC 2017
Anti-AMPA GluA3 antibodies in Frontotemporal dementia: a new molecular target.
Scientific reports
Borroni B,Stanic J,Verpelli C,Mellone M,Bonomi E,Alberici A,Bernasconi P,Culotta L,Zianni E,Archetti S,Manes M,Gazzina S,Ghidoni R,Benussi L,Stuani C,Di Luca M,Sala C,Buratti E,Padovani A,Gardoni F
Thu Jul 27 00:00:00 UTC 2017
TDP-43 misexpression causes defects in dendritic growth.
Scientific reports
Herzog JJ,Deshpande M,Shapiro L,Rodal AA,Paradis S
Wed Nov 15 00:00:00 UTC 2017
TDP-43 misexpression causes defects in dendritic growth.
Scientific reports
Herzog JJ,Deshpande M,Shapiro L,Rodal AA,Paradis S
Wed Nov 15 00:00:00 UTC 2017
Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant.
PloS one
Wobst HJ,Delsing L,Brandon NJ,Moss SJ
Wed Sep 06 00:00:00 UTC 2017
Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant.
PloS one
Wobst HJ,Delsing L,Brandon NJ,Moss SJ
Wed Sep 06 00:00:00 UTC 2017
Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant.
PloS one
Wobst HJ,Delsing L,Brandon NJ,Moss SJ
Wed Sep 06 00:00:00 UTC 2017
Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant.
PloS one
Wobst HJ,Delsing L,Brandon NJ,Moss SJ
Wed Sep 06 00:00:00 UTC 2017
18 F-flortaucipir tau positron emission tomography distinguishes established progressive supranuclear palsy from controls and Parkinson disease: A multicenter study.
Annals of neurology
Schonhaut DR,McMillan CT,Spina S,Dickerson BC,Siderowf A,Devous MD,Tsai R,Winer J,Russell DS,Litvan I,Roberson ED,Seeley WW,Grinberg LT,Kramer JH,Miller BL,Pressman P,Nasrallah I,Baker SL,Gomperts SN,Johnson KA,Grossman M,Jagust WJ,Boxer AL,Rabinovici GD
Sun Oct 01 00:00:00 UTC 2017
Dioxins and related environmental contaminants increase TDP-43 levels.
Molecular neurodegeneration
Ash PEA,Stanford EA,Al Abdulatif A,Ramirez-Cardenas A,Ballance HI,Boudeau S,Jeh A,Murithi JM,Tripodis Y,Murphy GJ,Sherr DH,Wolozin B
Fri May 05 00:00:00 UTC 2017
Dioxins and related environmental contaminants increase TDP-43 levels.
Molecular neurodegeneration
Ash PEA,Stanford EA,Al Abdulatif A,Ramirez-Cardenas A,Ballance HI,Boudeau S,Jeh A,Murithi JM,Tripodis Y,Murphy GJ,Sherr DH,Wolozin B
Fri May 05 00:00:00 UTC 2017
Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation.
Nature communications
Afroz T,Hock EM,Ernst P,Foglieni C,Jambeau M,Gilhespy LAB,Laferriere F,Maniecka Z,Plückthun A,Mittl P,Paganetti P,Allain FHT,Polymenidou M
Thu Jun 29 00:00:00 UTC 2017
Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation.
Nature communications
Afroz T,Hock EM,Ernst P,Foglieni C,Jambeau M,Gilhespy LAB,Laferriere F,Maniecka Z,Plückthun A,Mittl P,Paganetti P,Allain FHT,Polymenidou M
Thu Jun 29 00:00:00 UTC 2017
Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43A315T ALS/FTD mouse model.
Scientific reports
Bargsted L,Medinas DB,Martínez Traub F,Rozas P,Muñoz N,Nassif M,Jerez C,Catenaccio A,Court FA,Hetz C,Matus S
Fri Oct 27 00:00:00 UTC 2017
Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43A315T ALS/FTD mouse model.
Scientific reports
Bargsted L,Medinas DB,Martínez Traub F,Rozas P,Muñoz N,Nassif M,Jerez C,Catenaccio A,Court FA,Hetz C,Matus S
Fri Oct 27 00:00:00 UTC 2017
Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43A315T ALS/FTD mouse model.
Scientific reports
Bargsted L,Medinas DB,Martínez Traub F,Rozas P,Muñoz N,Nassif M,Jerez C,Catenaccio A,Court FA,Hetz C,Matus S
Fri Oct 27 00:00:00 UTC 2017
Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43A315T ALS/FTD mouse model.
Scientific reports
Bargsted L,Medinas DB,Martínez Traub F,Rozas P,Muñoz N,Nassif M,Jerez C,Catenaccio A,Court FA,Hetz C,Matus S
Fri Oct 27 00:00:00 UTC 2017
Neurotrophic effects of progranulin in vivo in reversing motor neuron defects caused by over or under expression of TDP-43 or FUS.
PloS one
Chitramuthu BP,Kay DG,Bateman A,Bennett HP
Mon Aug 28 00:00:00 UTC 2017
Neurotrophic effects of progranulin in vivo in reversing motor neuron defects caused by over or under expression of TDP-43 or FUS.
PloS one
Chitramuthu BP,Kay DG,Bateman A,Bennett HP
Mon Aug 28 00:00:00 UTC 2017
Valosin-containing protein (VCP/p97) inhibitors relieve Mitofusin-dependent mitochondrial defects due to VCP disease mutants.
eLife
Zhang T,Mishra P,Hay BA,Chan D,Guo M
Tue Mar 21 00:00:00 UTC 2017
Valosin-containing protein (VCP/p97) inhibitors relieve Mitofusin-dependent mitochondrial defects due to VCP disease mutants.
eLife
Zhang T,Mishra P,Hay BA,Chan D,Guo M
Tue Mar 21 00:00:00 UTC 2017
Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs.
Nature communications
Lyons SM,Gudanis D,Coyne SM,Gdaniec Z,Ivanov P
Tue Oct 24 00:00:00 UTC 2017
Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs.
Nature communications
Lyons SM,Gudanis D,Coyne SM,Gdaniec Z,Ivanov P
Tue Oct 24 00:00:00 UTC 2017
Heterogeneous ribonuclear protein E2 (hnRNP E2) is associated with TDP-43-immunoreactive neurites in Semantic Dementia but not with other TDP-43 pathological subtypes of Frontotemporal Lobar Degeneration.
Acta neuropathologica communications
Davidson YS,Robinson AC,Flood L,Rollinson S,Benson BC,Asi YT,Richardson A,Jones M,Snowden JS,Pickering-Brown S,Lashley T,Mann DMA
Fri Jun 30 00:00:00 UTC 2017
Heterogeneous ribonuclear protein E2 (hnRNP E2) is associated with TDP-43-immunoreactive neurites in Semantic Dementia but not with other TDP-43 pathological subtypes of Frontotemporal Lobar Degeneration.
Acta neuropathologica communications
Davidson YS,Robinson AC,Flood L,Rollinson S,Benson BC,Asi YT,Richardson A,Jones M,Snowden JS,Pickering-Brown S,Lashley T,Mann DMA
Fri Jun 30 00:00:00 UTC 2017
Heterogeneous ribonuclear protein E2 (hnRNP E2) is associated with TDP-43-immunoreactive neurites in Semantic Dementia but not with other TDP-43 pathological subtypes of Frontotemporal Lobar Degeneration.
Acta neuropathologica communications
Davidson YS,Robinson AC,Flood L,Rollinson S,Benson BC,Asi YT,Richardson A,Jones M,Snowden JS,Pickering-Brown S,Lashley T,Mann DMA
Fri Jun 30 00:00:00 UTC 2017
De novo design of RNA-binding proteins with a prion-like domain related to ALS/FTD proteinopathies.
Scientific reports
Mitsuhashi K,Ito D,Mashima K,Oyama M,Takahashi S,Suzuki N
Mon Dec 04 00:00:00 UTC 2017
De novo design of RNA-binding proteins with a prion-like domain related to ALS/FTD proteinopathies.
Scientific reports
Mitsuhashi K,Ito D,Mashima K,Oyama M,Takahashi S,Suzuki N
Mon Dec 04 00:00:00 UTC 2017
Overexpression of the essential Sis1 chaperone reduces TDP-43 effects on toxicity and proteolysis.
PLoS genetics
Park SK,Hong JY,Arslan F,Kanneganti V,Patel B,Tietsort A,Tank EMH,Li X,Barmada SJ,Liebman SW
Mon May 01 00:00:00 UTC 2017
Overexpression of the essential Sis1 chaperone reduces TDP-43 effects on toxicity and proteolysis.
PLoS genetics
Park SK,Hong JY,Arslan F,Kanneganti V,Patel B,Tietsort A,Tank EMH,Li X,Barmada SJ,Liebman SW
Mon May 01 00:00:00 UTC 2017
TDP-43 accelerates age-dependent degeneration of interneurons.
Scientific reports
Tsuiji H,Inoue I,Takeuchi M,Furuya A,Yamakage Y,Watanabe S,Koike M,Hattori M,Yamanaka K
Thu Nov 02 00:00:00 UTC 2017
TDP-43 accelerates age-dependent degeneration of interneurons.
Scientific reports
Tsuiji H,Inoue I,Takeuchi M,Furuya A,Yamakage Y,Watanabe S,Koike M,Hattori M,Yamanaka K
Thu Nov 02 00:00:00 UTC 2017
TDP-43 accelerates age-dependent degeneration of interneurons.
Scientific reports
Tsuiji H,Inoue I,Takeuchi M,Furuya A,Yamakage Y,Watanabe S,Koike M,Hattori M,Yamanaka K
Thu Nov 02 00:00:00 UTC 2017
TDP-43 accelerates age-dependent degeneration of interneurons.
Scientific reports
Tsuiji H,Inoue I,Takeuchi M,Furuya A,Yamakage Y,Watanabe S,Koike M,Hattori M,Yamanaka K
Thu Nov 02 00:00:00 UTC 2017
Single cell imaging and quantification of TDP-43 and α-synuclein intercellular propagation.
Scientific reports
Peled S,Sade D,Bram Y,Porat Z,Kreiser T,Mimouni M,Lichtenstein A,Segal D,Gazit E
Tue Mar 28 00:00:00 UTC 2017
Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS.
PLoS genetics
Krug L,Chatterjee N,Borges-Monroy R,Hearn S,Liao WW,Morrill K,Prazak L,Rozhkov N,Theodorou D,Hammell M,Dubnau J
Wed Mar 01 00:00:00 UTC 2017
Endocytosis regulates TDP-43 toxicity and turnover.
Nature communications
Liu G,Coyne AN,Pei F,Vaughan S,Chaung M,Zarnescu DC,Buchan JR
Tue Dec 12 00:00:00 UTC 2017
Endocytosis regulates TDP-43 toxicity and turnover.
Nature communications
Liu G,Coyne AN,Pei F,Vaughan S,Chaung M,Zarnescu DC,Buchan JR
Tue Dec 12 00:00:00 UTC 2017
Endocytosis regulates TDP-43 toxicity and turnover.
Nature communications
Liu G,Coyne AN,Pei F,Vaughan S,Chaung M,Zarnescu DC,Buchan JR
Tue Dec 12 00:00:00 UTC 2017
Endocytosis regulates TDP-43 toxicity and turnover.
Nature communications
Liu G,Coyne AN,Pei F,Vaughan S,Chaung M,Zarnescu DC,Buchan JR
Tue Dec 12 00:00:00 UTC 2017
Heterogeneous ribonuclear protein A3 (hnRNP A3) is present in dipeptide repeat protein containing inclusions in Frontotemporal Lobar Degeneration and Motor Neurone disease associated with expansions in C9orf72 gene.
Acta neuropathologica communications
Davidson YS,Flood L,Robinson AC,Nihei Y,Mori K,Rollinson S,Richardson A,Benson BC,Jones M,Snowden JS,Pickering-Brown S,Haass C,Lashley T,Mann DMA
Fri Apr 21 00:00:00 UTC 2017
Heterogeneous ribonuclear protein A3 (hnRNP A3) is present in dipeptide repeat protein containing inclusions in Frontotemporal Lobar Degeneration and Motor Neurone disease associated with expansions in C9orf72 gene.
Acta neuropathologica communications
Davidson YS,Flood L,Robinson AC,Nihei Y,Mori K,Rollinson S,Richardson A,Benson BC,Jones M,Snowden JS,Pickering-Brown S,Haass C,Lashley T,Mann DMA
Fri Apr 21 00:00:00 UTC 2017
Heat Shock-induced Phosphorylation of TAR DNA-binding Protein 43 (TDP-43) by MAPK/ERK Kinase Regulates TDP-43 Function.
The Journal of biological chemistry
Li W,Reeb AN,Lin B,Subramanian P,Fey EE,Knoverek CR,French RL,Bigio EH,Ayala YM
Fri Mar 24 00:00:00 UTC 2017
Heat Shock-induced Phosphorylation of TAR DNA-binding Protein 43 (TDP-43) by MAPK/ERK Kinase Regulates TDP-43 Function.
The Journal of biological chemistry
Li W,Reeb AN,Lin B,Subramanian P,Fey EE,Knoverek CR,French RL,Bigio EH,Ayala YM
Fri Mar 24 00:00:00 UTC 2017
Heat Shock-induced Phosphorylation of TAR DNA-binding Protein 43 (TDP-43) by MAPK/ERK Kinase Regulates TDP-43 Function.
The Journal of biological chemistry
Li W,Reeb AN,Lin B,Subramanian P,Fey EE,Knoverek CR,French RL,Bigio EH,Ayala YM
Fri Mar 24 00:00:00 UTC 2017
Heat Shock-induced Phosphorylation of TAR DNA-binding Protein 43 (TDP-43) by MAPK/ERK Kinase Regulates TDP-43 Function.
The Journal of biological chemistry
Li W,Reeb AN,Lin B,Subramanian P,Fey EE,Knoverek CR,French RL,Bigio EH,Ayala YM
Fri Mar 24 00:00:00 UTC 2017
DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy.
PLoS genetics
Shadle SC,Zhong JW,Campbell AE,Conerly ML,Jagannathan S,Wong CJ,Morello TD,van der Maarel SM,Tapscott SJ
Wed Mar 01 00:00:00 UTC 2017
DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy.
PLoS genetics
Shadle SC,Zhong JW,Campbell AE,Conerly ML,Jagannathan S,Wong CJ,Morello TD,van der Maarel SM,Tapscott SJ
Wed Mar 01 00:00:00 UTC 2017
Increased cytoplasmic TDP-43 reduces global protein synthesis by interacting with RACK1 on polyribosomes.
Human molecular genetics
Russo A,Scardigli R,La Regina F,Murray ME,Romano N,Dickson DW,Wolozin B,Cattaneo A,Ceci M
Sat Apr 15 00:00:00 UTC 2017
Increased cytoplasmic TDP-43 reduces global protein synthesis by interacting with RACK1 on polyribosomes.
Human molecular genetics
Russo A,Scardigli R,La Regina F,Murray ME,Romano N,Dickson DW,Wolozin B,Cattaneo A,Ceci M
Sat Apr 15 00:00:00 UTC 2017
Absence of Alzheimer Disease Neuropathologic Changes in Eyes of Subjects With Alzheimer Disease.
Journal of neuropathology and experimental neurology
Williams EA,McGuone D,Frosch MP,Hyman BT,Laver N,Stemmer-Rachamimov A
Mon May 01 00:00:00 UTC 2017
Impaired activation of ALS monocytes by exosomes.
Immunology and cell biology
Zondler L,Feiler MS,Freischmidt A,Ruf WP,Ludolph AC,Danzer KM,Weishaupt JH
Wed Feb 01 00:00:00 UTC 2017
Tdp-43 cryptic exons are highly variable between cell types.
Molecular neurodegeneration
Jeong YH,Ling JP,Lin SZ,Donde AN,Braunstein KE,Majounie E,Traynor BJ,LaClair KD,Lloyd TE,Wong PC
Thu Feb 02 00:00:00 UTC 2017
Tdp-43 cryptic exons are highly variable between cell types.
Molecular neurodegeneration
Jeong YH,Ling JP,Lin SZ,Donde AN,Braunstein KE,Majounie E,Traynor BJ,LaClair KD,Lloyd TE,Wong PC
Thu Feb 02 00:00:00 UTC 2017
Tdp-43 cryptic exons are highly variable between cell types.
Molecular neurodegeneration
Jeong YH,Ling JP,Lin SZ,Donde AN,Braunstein KE,Majounie E,Traynor BJ,LaClair KD,Lloyd TE,Wong PC
Thu Feb 02 00:00:00 UTC 2017
Tdp-43 cryptic exons are highly variable between cell types.
Molecular neurodegeneration
Jeong YH,Ling JP,Lin SZ,Donde AN,Braunstein KE,Majounie E,Traynor BJ,LaClair KD,Lloyd TE,Wong PC
Thu Feb 02 00:00:00 UTC 2017
Simple Derivation of Spinal Motor Neurons from ESCs/iPSCs Using Sendai Virus Vectors.
Molecular therapy. Methods & clinical development
Goto K,Imamura K,Komatsu K,Mitani K,Aiba K,Nakatsuji N,Inoue M,Kawata A,Yamashita H,Takahashi R,Inoue H
Fri Mar 17 00:00:00 UTC 2017
Simple Derivation of Spinal Motor Neurons from ESCs/iPSCs Using Sendai Virus Vectors.
Molecular therapy. Methods & clinical development
Goto K,Imamura K,Komatsu K,Mitani K,Aiba K,Nakatsuji N,Inoue M,Kawata A,Yamashita H,Takahashi R,Inoue H
Fri Mar 17 00:00:00 UTC 2017
Acetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program.
Nature communications
Wang P,Wander CM,Yuan CX,Bereman MS,Cohen TJ
Wed Jul 19 00:00:00 UTC 2017
Acetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program.
Nature communications
Wang P,Wander CM,Yuan CX,Bereman MS,Cohen TJ
Wed Jul 19 00:00:00 UTC 2017
Acetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program.
Nature communications
Wang P,Wander CM,Yuan CX,Bereman MS,Cohen TJ
Wed Jul 19 00:00:00 UTC 2017
Acetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program.
Nature communications
Wang P,Wander CM,Yuan CX,Bereman MS,Cohen TJ
Wed Jul 19 00:00:00 UTC 2017
Association between diabetes and causes of dementia: Evidence from a clinicopathological study.
Dementia & neuropsychologia
Matioli MNPDS,Suemoto CK,Rodriguez RD,Farias DS,da Silva MM,Leite REP,Ferretti-Rebustini REL,Pasqualucci CA,Jacob W,Grinberg LT,Nitrini R
Sun Nov 12 00:00:00 UTC 2023
Association between diabetes and causes of dementia: Evidence from a clinicopathological study.
Dementia & neuropsychologia
Matioli MNPDS,Suemoto CK,Rodriguez RD,Farias DS,da Silva MM,Leite REP,Ferretti-Rebustini REL,Pasqualucci CA,Jacob W,Grinberg LT,Nitrini R
Sun Nov 12 00:00:00 UTC 2023
TDP-43 protein variants as biomarkers in amyotrophic lateral sclerosis.
BMC neuroscience
Williams SM,Khan G,Harris BT,Ravits J,Sierks MR
Wed Jan 25 00:00:00 UTC 2017
TDP-43 protein variants as biomarkers in amyotrophic lateral sclerosis.
BMC neuroscience
Williams SM,Khan G,Harris BT,Ravits J,Sierks MR
Wed Jan 25 00:00:00 UTC 2017
TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway.
Human molecular genetics
Moujalled D,Grubman A,Acevedo K,Yang S,Ke YD,Moujalled DM,Duncan C,Caragounis A,Perera ND,Turner BJ,Prudencio M,Petrucelli L,Blair I,Ittner LM,Crouch PJ,Liddell JR,White AR
Mon May 01 00:00:00 UTC 2017
C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles.
Cell
Lee KH,Zhang P,Kim HJ,Mitrea DM,Sarkar M,Freibaum BD,Cika J,Coughlin M,Messing J,Molliex A,Maxwell BA,Kim NC,Temirov J,Moore J,Kolaitis RM,Shaw TI,Bai B,Peng J,Kriwacki RW,Taylor JP
Thu Oct 20 00:00:00 UTC 2016
C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles.
Cell
Lee KH,Zhang P,Kim HJ,Mitrea DM,Sarkar M,Freibaum BD,Cika J,Coughlin M,Messing J,Molliex A,Maxwell BA,Kim NC,Temirov J,Moore J,Kolaitis RM,Shaw TI,Bai B,Peng J,Kriwacki RW,Taylor JP
Thu Oct 20 00:00:00 UTC 2016
C9orf72 is required for proper macrophage and microglial function in mice.
Science (New York, N.Y.)
O'Rourke JG,Bogdanik L,Yáñez A,Lall D,Wolf AJ,Muhammad AK,Ho R,Carmona S,Vit JP,Zarrow J,Kim KJ,Bell S,Harms MB,Miller TM,Dangler CA,Underhill DM,Goodridge HS,Lutz CM,Baloh RH
Fri Mar 18 00:00:00 UTC 2016
C9orf72 is required for proper macrophage and microglial function in mice.
Science (New York, N.Y.)
O'Rourke JG,Bogdanik L,Yáñez A,Lall D,Wolf AJ,Muhammad AK,Ho R,Carmona S,Vit JP,Zarrow J,Kim KJ,Bell S,Harms MB,Miller TM,Dangler CA,Underhill DM,Goodridge HS,Lutz CM,Baloh RH
Fri Mar 18 00:00:00 UTC 2016
Unusual Processing Generates SPA LncRNAs that Sequester Multiple RNA Binding Proteins.
Molecular cell
Wu H,Yin QF,Luo Z,Yao RW,Zheng CC,Zhang J,Xiang JF,Yang L,Chen LL
Thu Nov 03 00:00:00 UTC 2016
Unusual Processing Generates SPA LncRNAs that Sequester Multiple RNA Binding Proteins.
Molecular cell
Wu H,Yin QF,Luo Z,Yao RW,Zheng CC,Zhang J,Xiang JF,Yang L,Chen LL
Thu Nov 03 00:00:00 UTC 2016
Unusual Processing Generates SPA LncRNAs that Sequester Multiple RNA Binding Proteins.
Molecular cell
Wu H,Yin QF,Luo Z,Yao RW,Zheng CC,Zhang J,Xiang JF,Yang L,Chen LL
Thu Nov 03 00:00:00 UTC 2016
Unusual Processing Generates SPA LncRNAs that Sequester Multiple RNA Binding Proteins.
Molecular cell
Wu H,Yin QF,Luo Z,Yao RW,Zheng CC,Zhang J,Xiang JF,Yang L,Chen LL
Thu Nov 03 00:00:00 UTC 2016
Increased cytoplasmic TARDBP mRNA in affected spinal motor neurons in ALS caused by abnormal autoregulation of TDP-43.
Nucleic acids research
Koyama A,Sugai A,Kato T,Ishihara T,Shiga A,Toyoshima Y,Koyama M,Konno T,Hirokawa S,Yokoseki A,Nishizawa M,Kakita A,Takahashi H,Onodera O
Fri Jul 08 00:00:00 UTC 2016
Increased cytoplasmic TARDBP mRNA in affected spinal motor neurons in ALS caused by abnormal autoregulation of TDP-43.
Nucleic acids research
Koyama A,Sugai A,Kato T,Ishihara T,Shiga A,Toyoshima Y,Koyama M,Konno T,Hirokawa S,Yokoseki A,Nishizawa M,Kakita A,Takahashi H,Onodera O
Fri Jul 08 00:00:00 UTC 2016
Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs.
Neuron
Jiang J,Zhu Q,Gendron TF,Saberi S,McAlonis-Downes M,Seelman A,Stauffer JE,Jafar-Nejad P,Drenner K,Schulte D,Chun S,Sun S,Ling SC,Myers B,Engelhardt J,Katz M,Baughn M,Platoshyn O,Marsala M,Watt A,Heyser CJ,Ard MC,De Muynck L,Daughrity LM,Swing DA,Tessarollo L,Jung CJ,Delpoux A,Utzschneider DT,Hedrick SM,de Jong PJ,Edbauer D,Van Damme P,Petrucelli L,Shaw CE,Bennett CF,Da Cruz S,Ravits J,Rigo F,Cleveland DW,Lagier-Tourenne C
Wed May 04 00:00:00 UTC 2016
Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs.
Neuron
Jiang J,Zhu Q,Gendron TF,Saberi S,McAlonis-Downes M,Seelman A,Stauffer JE,Jafar-Nejad P,Drenner K,Schulte D,Chun S,Sun S,Ling SC,Myers B,Engelhardt J,Katz M,Baughn M,Platoshyn O,Marsala M,Watt A,Heyser CJ,Ard MC,De Muynck L,Daughrity LM,Swing DA,Tessarollo L,Jung CJ,Delpoux A,Utzschneider DT,Hedrick SM,de Jong PJ,Edbauer D,Van Damme P,Petrucelli L,Shaw CE,Bennett CF,Da Cruz S,Ravits J,Rigo F,Cleveland DW,Lagier-Tourenne C
Wed May 04 00:00:00 UTC 2016
Depletion of TDP-43 decreases fibril and plaque β-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model.
Acta neuropathologica
LaClair KD,Donde A,Ling JP,Jeong YH,Chhabra R,Martin LJ,Wong PC
Thu Dec 01 00:00:00 UTC 2016
Depletion of TDP-43 decreases fibril and plaque β-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model.
Acta neuropathologica
LaClair KD,Donde A,Ling JP,Jeong YH,Chhabra R,Martin LJ,Wong PC
Thu Dec 01 00:00:00 UTC 2016
MTHFSD and DDX58 are novel RNA-binding proteins abnormally regulated in amyotrophic lateral sclerosis.
Brain : a journal of neurology
MacNair L,Xiao S,Miletic D,Ghani M,Julien JP,Keith J,Zinman L,Rogaeva E,Robertson J
Fri Jan 01 00:00:00 UTC 2016
MTHFSD and DDX58 are novel RNA-binding proteins abnormally regulated in amyotrophic lateral sclerosis.
Brain : a journal of neurology
MacNair L,Xiao S,Miletic D,Ghani M,Julien JP,Keith J,Zinman L,Rogaeva E,Robertson J
Fri Jan 01 00:00:00 UTC 2016
The heat shock response plays an important role in TDP-43 clearance: evidence for dysfunction in amyotrophic lateral sclerosis.
Brain : a journal of neurology
Chen HJ,Mitchell JC,Novoselov S,Miller J,Nishimura AL,Scotter EL,Vance CA,Cheetham ME,Shaw CE
Sun May 01 00:00:00 UTC 2016
The heat shock response plays an important role in TDP-43 clearance: evidence for dysfunction in amyotrophic lateral sclerosis.
Brain : a journal of neurology
Chen HJ,Mitchell JC,Novoselov S,Miller J,Nishimura AL,Scotter EL,Vance CA,Cheetham ME,Shaw CE
Sun May 01 00:00:00 UTC 2016
Clinical features of TBK1 carriers compared with C9orf72, GRN and non-mutation carriers in a Belgian cohort.
Brain : a journal of neurology
Van Mossevelde S,van der Zee J,Gijselinck I,Engelborghs S,Sieben A,Van Langenhove T,De Bleecker J,Baets J,Vandenbulcke M,Van Laere K,Ceyssens S,Van den Broeck M,Peeters K,Mattheijssens M,Cras P,Vandenberghe R,De Jonghe P,Martin JJ,De Deyn PP,Cruts M,Van Broeckhoven C
Mon Feb 01 00:00:00 UTC 2016
Clinical features of TBK1 carriers compared with C9orf72, GRN and non-mutation carriers in a Belgian cohort.
Brain : a journal of neurology
Van Mossevelde S,van der Zee J,Gijselinck I,Engelborghs S,Sieben A,Van Langenhove T,De Bleecker J,Baets J,Vandenbulcke M,Van Laere K,Ceyssens S,Van den Broeck M,Peeters K,Mattheijssens M,Cras P,Vandenberghe R,De Jonghe P,Martin JJ,De Deyn PP,Cruts M,Van Broeckhoven C
Mon Feb 01 00:00:00 UTC 2016
Timing and significance of pathological features in C9orf72 expansion-associated frontotemporal dementia.
Brain : a journal of neurology
Vatsavayai SC,Yoon SJ,Gardner RC,Gendron TF,Vargas JN,Trujillo A,Pribadi M,Phillips JJ,Gaus SE,Hixson JD,Garcia PA,Rabinovici GD,Coppola G,Geschwind DH,Petrucelli L,Miller BL,Seeley WW
Thu Dec 01 00:00:00 UTC 2016
Timing and significance of pathological features in C9orf72 expansion-associated frontotemporal dementia.
Brain : a journal of neurology
Vatsavayai SC,Yoon SJ,Gardner RC,Gendron TF,Vargas JN,Trujillo A,Pribadi M,Phillips JJ,Gaus SE,Hixson JD,Garcia PA,Rabinovici GD,Coppola G,Geschwind DH,Petrucelli L,Miller BL,Seeley WW
Thu Dec 01 00:00:00 UTC 2016
ALS-linked protein disulfide isomerase variants cause motor dysfunction.
The EMBO journal
Woehlbier U,Colombo A,Saaranen MJ,Pérez V,Ojeda J,Bustos FJ,Andreu CI,Torres M,Valenzuela V,Medinas DB,Rozas P,Vidal RL,Lopez-Gonzalez R,Salameh J,Fernandez-Collemann S,Muñoz N,Matus S,Armisen R,Sagredo A,Palma K,Irrazabal T,Almeida S,Gonzalez-Perez P,Campero M,Gao FB,Henny P,van Zundert B,Ruddock LW,Concha ML,Henriquez JP,Brown RH,Hetz C
Fri Apr 15 00:00:00 UTC 2016
ALS-linked protein disulfide isomerase variants cause motor dysfunction.
The EMBO journal
Woehlbier U,Colombo A,Saaranen MJ,Pérez V,Ojeda J,Bustos FJ,Andreu CI,Torres M,Valenzuela V,Medinas DB,Rozas P,Vidal RL,Lopez-Gonzalez R,Salameh J,Fernandez-Collemann S,Muñoz N,Matus S,Armisen R,Sagredo A,Palma K,Irrazabal T,Almeida S,Gonzalez-Perez P,Campero M,Gao FB,Henny P,van Zundert B,Ruddock LW,Concha ML,Henriquez JP,Brown RH,Hetz C
Fri Apr 15 00:00:00 UTC 2016
TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion.
The EMBO journal
Xia Q,Wang H,Hao Z,Fu C,Hu Q,Gao F,Ren H,Chen D,Han J,Ying Z,Wang G
Mon Jan 18 00:00:00 UTC 2016
TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion.
The EMBO journal
Xia Q,Wang H,Hao Z,Fu C,Hu Q,Gao F,Ren H,Chen D,Han J,Ying Z,Wang G
Mon Jan 18 00:00:00 UTC 2016
Severe muscle wasting and denervation in mice lacking the RNA-binding protein ZFP106.
Proceedings of the National Academy of Sciences of the United States of America
Anderson DM,Cannavino J,Li H,Anderson KM,Nelson BR,McAnally J,Bezprozvannaya S,Liu Y,Lin W,Liu N,Bassel-Duby R,Olson EN
Tue Aug 02 00:00:00 UTC 2016
Phenotypic characteristics of Alzheimer patients carrying an ABCA7 mutation.
Neurology
Van den Bossche T,Sleegers K,Cuyvers E,Engelborghs S,Sieben A,De Roeck A,Van Cauwenberghe C,Vermeulen S,Van den Broeck M,Laureys A,Peeters K,Mattheijssens M,Vandenbulcke M,Vandenberghe R,Martin JJ,De Deyn PP,Cras P,Van Broeckhoven C
Tue Jun 07 00:00:00 UTC 2016
Phenotypic characteristics of Alzheimer patients carrying an ABCA7 mutation.
Neurology
Van den Bossche T,Sleegers K,Cuyvers E,Engelborghs S,Sieben A,De Roeck A,Van Cauwenberghe C,Vermeulen S,Van den Broeck M,Laureys A,Peeters K,Mattheijssens M,Vandenbulcke M,Vandenberghe R,Martin JJ,De Deyn PP,Cras P,Van Broeckhoven C
Tue Jun 07 00:00:00 UTC 2016
Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy.
American journal of human genetics
Lesage S,Drouet V,Majounie E,Deramecourt V,Jacoupy M,Nicolas A,Cormier-Dequaire F,Hassoun SM,Pujol C,Ciura S,Erpapazoglou Z,Usenko T,Maurage CA,Sahbatou M,Liebau S,Ding J,Bilgic B,Emre M,Erginel-Unaltuna N,Guven G,Tison F,Tranchant C,Vidailhet M,Corvol JC,Krack P,Leutenegger AL,Nalls MA,Hernandez DG,Heutink P,Gibbs JR,Hardy J,Wood NW,Gasser T,Durr A,Deleuze JF,Tazir M,Destée A,Lohmann E,Kabashi E,Singleton A,Corti O,Brice A
Thu Mar 03 00:00:00 UTC 2016
Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy.
American journal of human genetics
Lesage S,Drouet V,Majounie E,Deramecourt V,Jacoupy M,Nicolas A,Cormier-Dequaire F,Hassoun SM,Pujol C,Ciura S,Erpapazoglou Z,Usenko T,Maurage CA,Sahbatou M,Liebau S,Ding J,Bilgic B,Emre M,Erginel-Unaltuna N,Guven G,Tison F,Tranchant C,Vidailhet M,Corvol JC,Krack P,Leutenegger AL,Nalls MA,Hernandez DG,Heutink P,Gibbs JR,Hardy J,Wood NW,Gasser T,Durr A,Deleuze JF,Tazir M,Destée A,Lohmann E,Kabashi E,Singleton A,Corti O,Brice A
Thu Mar 03 00:00:00 UTC 2016
Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition.
EMBO reports
Mori K,Nihei Y,Arzberger T,Zhou Q,Mackenzie IR,Hermann A,Hanisch F,Kamp F,Nuscher B,Orozco D,Edbauer D,Haass C
Thu Sep 01 00:00:00 UTC 2016
Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition.
EMBO reports
Mori K,Nihei Y,Arzberger T,Zhou Q,Mackenzie IR,Hermann A,Hanisch F,Kamp F,Nuscher B,Orozco D,Edbauer D,Haass C
Thu Sep 01 00:00:00 UTC 2016
Structural, super-resolution microscopy analysis of paraspeckle nuclear body organization.
The Journal of cell biology
West JA,Mito M,Kurosaka S,Takumi T,Tanegashima C,Chujo T,Yanaka K,Kingston RE,Hirose T,Bond C,Fox A,Nakagawa S
Mon Sep 26 00:00:00 UTC 2016
Structural, super-resolution microscopy analysis of paraspeckle nuclear body organization.
The Journal of cell biology
West JA,Mito M,Kurosaka S,Takumi T,Tanegashima C,Chujo T,Yanaka K,Kingston RE,Hirose T,Bond C,Fox A,Nakagawa S
Mon Sep 26 00:00:00 UTC 2016
G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits.
The Journal of cell biology
Kedersha N,Panas MD,Achorn CA,Lyons S,Tisdale S,Hickman T,Thomas M,Lieberman J,McInerney GM,Ivanov P,Anderson P
Mon Mar 28 00:00:00 UTC 2016
G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits.
The Journal of cell biology
Kedersha N,Panas MD,Achorn CA,Lyons S,Tisdale S,Hickman T,Thomas M,Lieberman J,McInerney GM,Ivanov P,Anderson P
Mon Mar 28 00:00:00 UTC 2016
In vitro prion-like behaviour of TDP-43 in ALS.
Neurobiology of disease
Smethurst P,Newcombe J,Troakes C,Simone R,Chen YR,Patani R,Sidle K
Thu Dec 01 00:00:00 UTC 2016
In vitro prion-like behaviour of TDP-43 in ALS.
Neurobiology of disease
Smethurst P,Newcombe J,Troakes C,Simone R,Chen YR,Patani R,Sidle K
Thu Dec 01 00:00:00 UTC 2016
Level of PICALM, a key component of clathrin-mediated endocytosis, is correlated with levels of phosphotau and autophagy-related proteins and is associated with tau inclusions in AD, PSP and Pick disease.
Neurobiology of disease
Ando K,Tomimura K,Sazdovitch V,Suain V,Yilmaz Z,Authelet M,Ndjim M,Vergara C,Belkouch M,Potier MC,Duyckaerts C,Brion JP
Sat Oct 01 00:00:00 UTC 2016
Level of PICALM, a key component of clathrin-mediated endocytosis, is correlated with levels of phosphotau and autophagy-related proteins and is associated with tau inclusions in AD, PSP and Pick disease.
Neurobiology of disease
Ando K,Tomimura K,Sazdovitch V,Suain V,Yilmaz Z,Authelet M,Ndjim M,Vergara C,Belkouch M,Potier MC,Duyckaerts C,Brion JP
Sat Oct 01 00:00:00 UTC 2016
Neurodegeneration in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9orf72 is linked to TDP-43 pathology and not associated with aggregated forms of dipeptide repeat proteins.
Neuropathology and applied neurobiology
Davidson Y,Robinson AC,Liu X,Wu D,Troakes C,Rollinson S,Masuda-Suzukake M,Suzuki G,Nonaka T,Shi J,Tian J,Hamdalla H,Ealing J,Richardson A,Jones M,Pickering-Brown S,Snowden JS,Hasegawa M,Mann DM
Fri Apr 01 00:00:00 UTC 2016
Motor neurone disease/amyotrophic lateral sclerosis associated with intermediate-length CAG repeat expansions in Ataxin-2 does not have 1C2-positive polyglutamine inclusions.
Neuropathology and applied neurobiology
Highley JR,Lorente Pons A,Cooper-Knock J,Wharton SB,Ince PG,Shaw PJ,Wood J,Kirby J
Wed Jun 01 00:00:00 UTC 2016
Motor neurone disease/amyotrophic lateral sclerosis associated with intermediate-length CAG repeat expansions in Ataxin-2 does not have 1C2-positive polyglutamine inclusions.
Neuropathology and applied neurobiology
Highley JR,Lorente Pons A,Cooper-Knock J,Wharton SB,Ince PG,Shaw PJ,Wood J,Kirby J
Wed Jun 01 00:00:00 UTC 2016
Multiple sclerosis masquerading as Alzheimer-type dementia: Clinical, radiological and pathological findings.
Multiple sclerosis (Houndmills, Basingstoke, England)
Tobin WO,Popescu BF,Lowe V,Pirko I,Parisi JE,Kantarci K,Fields JA,Bruns MB,Boeve BF,Lucchinetti CF
Fri Apr 01 00:00:00 UTC 2016
Multiple sclerosis masquerading as Alzheimer-type dementia: Clinical, radiological and pathological findings.
Multiple sclerosis (Houndmills, Basingstoke, England)
Tobin WO,Popescu BF,Lowe V,Pirko I,Parisi JE,Kantarci K,Fields JA,Bruns MB,Boeve BF,Lucchinetti CF
Fri Apr 01 00:00:00 UTC 2016
A novel Drosophila model of TDP-43 proteinopathies: N-terminal sequences combined with the Q/N domain induce protein functional loss and locomotion defects.
Disease models & mechanisms
Langellotti S,Romano V,Romano G,Klima R,Feiguin F,Cragnaz L,Romano M,Baralle FE
Wed Jun 01 00:00:00 UTC 2016
A novel Drosophila model of TDP-43 proteinopathies: N-terminal sequences combined with the Q/N domain induce protein functional loss and locomotion defects.
Disease models & mechanisms
Langellotti S,Romano V,Romano G,Klima R,Feiguin F,Cragnaz L,Romano M,Baralle FE
Wed Jun 01 00:00:00 UTC 2016
Tyrosine kinase inhibition reverses TDP-43 effects on synaptic protein expression, astrocytic function and amino acid dis-homeostasis.
Journal of neurochemistry
Heyburn L,Hebron ML,Smith J,Winston C,Bechara J,Li Z,Lonskaya I,Burns MP,Harris BT,Moussa CE
Tue Nov 01 00:00:00 UTC 2016
Tyrosine kinase inhibition reverses TDP-43 effects on synaptic protein expression, astrocytic function and amino acid dis-homeostasis.
Journal of neurochemistry
Heyburn L,Hebron ML,Smith J,Winston C,Bechara J,Li Z,Lonskaya I,Burns MP,Harris BT,Moussa CE
Tue Nov 01 00:00:00 UTC 2016
Tyrosine kinase inhibition reverses TDP-43 effects on synaptic protein expression, astrocytic function and amino acid dis-homeostasis.
Journal of neurochemistry
Heyburn L,Hebron ML,Smith J,Winston C,Bechara J,Li Z,Lonskaya I,Burns MP,Harris BT,Moussa CE
Tue Nov 01 00:00:00 UTC 2016
Tyrosine kinase inhibition reverses TDP-43 effects on synaptic protein expression, astrocytic function and amino acid dis-homeostasis.
Journal of neurochemistry
Heyburn L,Hebron ML,Smith J,Winston C,Bechara J,Li Z,Lonskaya I,Burns MP,Harris BT,Moussa CE
Tue Nov 01 00:00:00 UTC 2016
Poly-dipeptides encoded by the C9ORF72 repeats block global protein translation.
Human molecular genetics
Kanekura K,Yagi T,Cammack AJ,Mahadevan J,Kuroda M,Harms MB,Miller TM,Urano F
Sun May 01 00:00:00 UTC 2016
Poly-dipeptides encoded by the C9ORF72 repeats block global protein translation.
Human molecular genetics
Kanekura K,Yagi T,Cammack AJ,Mahadevan J,Kuroda M,Harms MB,Miller TM,Urano F
Sun May 01 00:00:00 UTC 2016
Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice.
Human molecular genetics
Perera ND,Sheean RK,Crouch PJ,White AR,Horne MK,Turner BJ
Thu Sep 15 00:00:00 UTC 2016
Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice.
Human molecular genetics
Perera ND,Sheean RK,Crouch PJ,White AR,Horne MK,Turner BJ
Thu Sep 15 00:00:00 UTC 2016
Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice.
Human molecular genetics
Perera ND,Sheean RK,Crouch PJ,White AR,Horne MK,Turner BJ
Thu Sep 15 00:00:00 UTC 2016
Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice.
Human molecular genetics
Perera ND,Sheean RK,Crouch PJ,White AR,Horne MK,Turner BJ
Thu Sep 15 00:00:00 UTC 2016
Cytoplasmic aggregates of dynactin in iPSC-derived tyrosine hydroxylase-positive neurons from a patient with Perry syndrome.
Parkinsonism & related disorders
Mishima T,Ishikawa T,Imamura K,Kondo T,Koshiba Y,Takahashi R,Takahashi J,Watanabe A,Fujii N,Tsuboi Y,Inoue H
Thu Sep 01 00:00:00 UTC 2016
Cytoplasmic aggregates of dynactin in iPSC-derived tyrosine hydroxylase-positive neurons from a patient with Perry syndrome.
Parkinsonism & related disorders
Mishima T,Ishikawa T,Imamura K,Kondo T,Koshiba Y,Takahashi R,Takahashi J,Watanabe A,Fujii N,Tsuboi Y,Inoue H
Thu Sep 01 00:00:00 UTC 2016
Melatonin enhances arsenic trioxide-induced cell death via sustained upregulation of Redd1 expression in breast cancer cells.
Molecular and cellular endocrinology
Yun SM,Woo SH,Oh ST,Hong SE,Choe TB,Ye SK,Kim EK,Seong MK,Kim HA,Noh WC,Lee JK,Jin HO,Lee YH,Park IC
Mon Feb 15 00:00:00 UTC 2016
Melatonin enhances arsenic trioxide-induced cell death via sustained upregulation of Redd1 expression in breast cancer cells.
Molecular and cellular endocrinology
Yun SM,Woo SH,Oh ST,Hong SE,Choe TB,Ye SK,Kim EK,Seong MK,Kim HA,Noh WC,Lee JK,Jin HO,Lee YH,Park IC
Mon Feb 15 00:00:00 UTC 2016
Chronic Traumatic Encephalopathy Presenting as Alzheimer's Disease in a Retired Soccer Player.
Journal of Alzheimer's disease : JAD
Grinberg LT,Anghinah R,Nascimento CF,Amaro E,Leite RP,Martin Mda G,Naslavsky MS,Takada LT,Filho WJ,Pasqualucci CA,Nitrini R
Fri Jul 29 00:00:00 UTC 2016
Chronic Traumatic Encephalopathy Presenting as Alzheimer's Disease in a Retired Soccer Player.
Journal of Alzheimer's disease : JAD
Grinberg LT,Anghinah R,Nascimento CF,Amaro E,Leite RP,Martin Mda G,Naslavsky MS,Takada LT,Filho WJ,Pasqualucci CA,Nitrini R
Fri Jul 29 00:00:00 UTC 2016
Role of BMP receptor traffic in synaptic growth defects in an ALS model.
Molecular biology of the cell
Deshpande M,Feiger Z,Shilton AK,Luo CC,Silverman E,Rodal AA
Sat Oct 01 00:00:00 UTC 2016
Role of BMP receptor traffic in synaptic growth defects in an ALS model.
Molecular biology of the cell
Deshpande M,Feiger Z,Shilton AK,Luo CC,Silverman E,Rodal AA
Sat Oct 01 00:00:00 UTC 2016
Role of BMP receptor traffic in synaptic growth defects in an ALS model.
Molecular biology of the cell
Deshpande M,Feiger Z,Shilton AK,Luo CC,Silverman E,Rodal AA
Sat Oct 01 00:00:00 UTC 2016
Role of BMP receptor traffic in synaptic growth defects in an ALS model.
Molecular biology of the cell
Deshpande M,Feiger Z,Shilton AK,Luo CC,Silverman E,Rodal AA
Sat Oct 01 00:00:00 UTC 2016
The extreme N-terminus of TDP-43 mediates the cytoplasmic aggregation of TDP-43 and associated toxicity in vivo.
Brain research
Sasaguri H,Chew J,Xu YF,Gendron TF,Garrett A,Lee CW,Jansen-West K,Bauer PO,Perkerson EA,Tong J,Stetler C,Zhang YJ
Thu Sep 15 00:00:00 UTC 2016
The extreme N-terminus of TDP-43 mediates the cytoplasmic aggregation of TDP-43 and associated toxicity in vivo.
Brain research
Sasaguri H,Chew J,Xu YF,Gendron TF,Garrett A,Lee CW,Jansen-West K,Bauer PO,Perkerson EA,Tong J,Stetler C,Zhang YJ
Thu Sep 15 00:00:00 UTC 2016
Immunoprecipitation and mass spectrometry defines an extensive RBM45 protein-protein interaction network.
Brain research
Li Y,Collins M,An J,Geiser R,Tegeler T,Tsantilas K,Garcia K,Pirrotte P,Bowser R
Thu Sep 15 00:00:00 UTC 2016
Immunoprecipitation and mass spectrometry defines an extensive RBM45 protein-protein interaction network.
Brain research
Li Y,Collins M,An J,Geiser R,Tegeler T,Tsantilas K,Garcia K,Pirrotte P,Bowser R
Thu Sep 15 00:00:00 UTC 2016
DYT6 Dystonia: A Neuropathological Study.
Neuro-degenerative diseases
Paudel R,Li A,Hardy J,Bhatia KP,Houlden H,Holton J
Wed Dec 28 00:00:00 UTC 2016
DYT6 Dystonia: A Neuropathological Study.
Neuro-degenerative diseases
Paudel R,Li A,Hardy J,Bhatia KP,Houlden H,Holton J
Wed Dec 28 00:00:00 UTC 2016
Shared Molecular Mechanisms in Alzheimer's Disease and Amyotrophic Lateral Sclerosis: Neurofilament-Dependent Transport of sAPP, FUS, TDP-43 and SOD1, with Endoplasmic Reticulum-Like Tubules.
Neuro-degenerative diseases
Muresan V,Ladescu Muresan Z
Tue Sep 20 00:00:00 UTC 2016
Shared Molecular Mechanisms in Alzheimer's Disease and Amyotrophic Lateral Sclerosis: Neurofilament-Dependent Transport of sAPP, FUS, TDP-43 and SOD1, with Endoplasmic Reticulum-Like Tubules.
Neuro-degenerative diseases
Muresan V,Ladescu Muresan Z
Tue Sep 20 00:00:00 UTC 2016
Shared Molecular Mechanisms in Alzheimer's Disease and Amyotrophic Lateral Sclerosis: Neurofilament-Dependent Transport of sAPP, FUS, TDP-43 and SOD1, with Endoplasmic Reticulum-Like Tubules.
Neuro-degenerative diseases
Muresan V,Ladescu Muresan Z
Tue Sep 20 00:00:00 UTC 2016
Shared Molecular Mechanisms in Alzheimer's Disease and Amyotrophic Lateral Sclerosis: Neurofilament-Dependent Transport of sAPP, FUS, TDP-43 and SOD1, with Endoplasmic Reticulum-Like Tubules.
Neuro-degenerative diseases
Muresan V,Ladescu Muresan Z
Tue Sep 20 00:00:00 UTC 2016
Imbalance of mitochondrial dynamics in Drosophila models of amyotrophic lateral sclerosis.
Biochemical and biophysical research communications
Altanbyek V,Cha SJ,Kang GU,Im DS,Lee S,Kim HJ,Kim K
Fri Dec 09 00:00:00 UTC 2016
Imbalance of mitochondrial dynamics in Drosophila models of amyotrophic lateral sclerosis.
Biochemical and biophysical research communications
Altanbyek V,Cha SJ,Kang GU,Im DS,Lee S,Kim HJ,Kim K
Fri Dec 09 00:00:00 UTC 2016
Imbalance of mitochondrial dynamics in Drosophila models of amyotrophic lateral sclerosis.
Biochemical and biophysical research communications
Altanbyek V,Cha SJ,Kang GU,Im DS,Lee S,Kim HJ,Kim K
Fri Dec 09 00:00:00 UTC 2016
Imbalance of mitochondrial dynamics in Drosophila models of amyotrophic lateral sclerosis.
Biochemical and biophysical research communications
Altanbyek V,Cha SJ,Kang GU,Im DS,Lee S,Kim HJ,Kim K
Fri Dec 09 00:00:00 UTC 2016
Marked Involvement of the Striatal Efferent System in TAR DNA-Binding Protein 43 kDa-Related Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis.
Journal of neuropathology and experimental neurology
Riku Y,Watanabe H,Yoshida M,Mimuro M,Iwasaki Y,Masuda M,Ishigaki S,Katsuno M,Sobue G
Mon Aug 01 00:00:00 UTC 2016
Marked Involvement of the Striatal Efferent System in TAR DNA-Binding Protein 43 kDa-Related Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis.
Journal of neuropathology and experimental neurology
Riku Y,Watanabe H,Yoshida M,Mimuro M,Iwasaki Y,Masuda M,Ishigaki S,Katsuno M,Sobue G
Mon Aug 01 00:00:00 UTC 2016
Argyrophilic Grain Disease: Demographics, Clinical, and Neuropathological Features From a Large Autopsy Study.
Journal of neuropathology and experimental neurology
Rodriguez RD,Suemoto CK,Molina M,Nascimento CF,Leite RE,de Lucena Ferretti-Rebustini RE,Farfel JM,Heinsen H,Nitrini R,Ueda K,Pasqualucci CA,Jacob-Filho W,Yaffe K,Grinberg LT
Fri Jul 01 00:00:00 UTC 2016
Argyrophilic Grain Disease: Demographics, Clinical, and Neuropathological Features From a Large Autopsy Study.
Journal of neuropathology and experimental neurology
Rodriguez RD,Suemoto CK,Molina M,Nascimento CF,Leite RE,de Lucena Ferretti-Rebustini RE,Farfel JM,Heinsen H,Nitrini R,Ueda K,Pasqualucci CA,Jacob-Filho W,Yaffe K,Grinberg LT
Fri Jul 01 00:00:00 UTC 2016
T-Cell-Mediated Inflammatory Myopathies in HIV-Positive Individuals: A Histologic Study of 19 Cases.
Journal of neuropathology and experimental neurology
Hiniker A,Daniels BH,Margeta M
Tue Mar 01 00:00:00 UTC 2016
T-Cell-Mediated Inflammatory Myopathies in HIV-Positive Individuals: A Histologic Study of 19 Cases.
Journal of neuropathology and experimental neurology
Hiniker A,Daniels BH,Margeta M
Tue Mar 01 00:00:00 UTC 2016
Hippocampal Sclerosis but Not Normal Aging or Alzheimer Disease Is Associated With TDP-43 Pathology in the Basal Forebrain of Aged Persons.
Journal of neuropathology and experimental neurology
Cykowski MD,Takei H,Van Eldik LJ,Schmitt FA,Jicha GA,Powell SZ,Nelson PT
Sun May 01 00:00:00 UTC 2016
Hippocampal Sclerosis but Not Normal Aging or Alzheimer Disease Is Associated With TDP-43 Pathology in the Basal Forebrain of Aged Persons.
Journal of neuropathology and experimental neurology
Cykowski MD,Takei H,Van Eldik LJ,Schmitt FA,Jicha GA,Powell SZ,Nelson PT
Sun May 01 00:00:00 UTC 2016
Analysis of RNA metabolism in peripheral WBCs of TDP-43 KI mice identifies novel biomarkers of ALS.
Neuroscience research
Hasegawa M,Hara-Miyauchi C,Ohta H,Sakimura K,Okano H,Okano HJ
Sun May 01 00:00:00 UTC 2016
Analysis of RNA metabolism in peripheral WBCs of TDP-43 KI mice identifies novel biomarkers of ALS.
Neuroscience research
Hasegawa M,Hara-Miyauchi C,Ohta H,Sakimura K,Okano H,Okano HJ
Sun May 01 00:00:00 UTC 2016
Analysis of RNA metabolism in peripheral WBCs of TDP-43 KI mice identifies novel biomarkers of ALS.
Neuroscience research
Hasegawa M,Hara-Miyauchi C,Ohta H,Sakimura K,Okano H,Okano HJ
Sun May 01 00:00:00 UTC 2016
Analysis of RNA metabolism in peripheral WBCs of TDP-43 KI mice identifies novel biomarkers of ALS.
Neuroscience research
Hasegawa M,Hara-Miyauchi C,Ohta H,Sakimura K,Okano H,Okano HJ
Sun May 01 00:00:00 UTC 2016
Serine 403-phosphorylated p62/SQSTM1 immunoreactivity in inclusions of neurodegenerative diseases.
Neuroscience research
Kurosawa M,Matsumoto G,Sumikura H,Hatsuta H,Murayama S,Sakurai T,Shimogori T,Hattori N,Nukina N
Mon Feb 01 00:00:00 UTC 2016
Serine 403-phosphorylated p62/SQSTM1 immunoreactivity in inclusions of neurodegenerative diseases.
Neuroscience research
Kurosawa M,Matsumoto G,Sumikura H,Hatsuta H,Murayama S,Sakurai T,Shimogori T,Hattori N,Nukina N
Mon Feb 01 00:00:00 UTC 2016
Phosphorylated TDP-43 becomes resistant to cleavage by calpain: A regulatory role for phosphorylation in TDP-43 pathology of ALS/FTLD.
Neuroscience research
Yamashita T,Teramoto S,Kwak S
Wed Jun 01 00:00:00 UTC 2016
Phosphorylated TDP-43 becomes resistant to cleavage by calpain: A regulatory role for phosphorylation in TDP-43 pathology of ALS/FTLD.
Neuroscience research
Yamashita T,Teramoto S,Kwak S
Wed Jun 01 00:00:00 UTC 2016
Progression of tau pathology within cholinergic nucleus basalis neurons in chronic traumatic encephalopathy: A chronic effects of neurotrauma consortium study.
Brain injury
Mufson EJ,Perez SE,Nadeem M,Mahady L,Kanaan NM,Abrahamson EE,Ikonomovic MD,Crawford F,Alvarez V,Stein T,McKee AC
Wed Jan 03 00:00:00 UTC 2018
Progression of tau pathology within cholinergic nucleus basalis neurons in chronic traumatic encephalopathy: A chronic effects of neurotrauma consortium study.
Brain injury
Mufson EJ,Perez SE,Nadeem M,Mahady L,Kanaan NM,Abrahamson EE,Ikonomovic MD,Crawford F,Alvarez V,Stein T,McKee AC
Wed Jan 03 00:00:00 UTC 2018
An autopsy case of frontotemporal lobar degeneration with the appearance of fused in sarcoma inclusions (basophilic inclusion body disease) clinically presenting corticobasal syndrome.
Neuropathology : official journal of the Japanese Society of Neuropathology
Matsumoto A,Suzuki H,Fukatsu R,Shimizu H,Suzuki Y,Hisanaga K
Mon Feb 01 00:00:00 UTC 2016
Clinicopathological description of two cases with SQSTM1 gene mutation associated with frontotemporal dementia.
Neuropathology : official journal of the Japanese Society of Neuropathology
Kovacs GG,van der Zee J,Hort J,Kristoferitsch W,Leitha T,Höftberger R,Ströbel T,Van Broeckhoven C,Matej R
Mon Feb 01 00:00:00 UTC 2016
Clinicopathological description of two cases with SQSTM1 gene mutation associated with frontotemporal dementia.
Neuropathology : official journal of the Japanese Society of Neuropathology
Kovacs GG,van der Zee J,Hort J,Kristoferitsch W,Leitha T,Höftberger R,Ströbel T,Van Broeckhoven C,Matej R
Mon Feb 01 00:00:00 UTC 2016
Mixed tau and TDP-43 pathology in a patient with unclassifiable primary progressive aphasia.
Neurocase
Flanagan EP,Duffy JR,Whitwell JL,Vemuri P,Dickson DW,Josephs KA
Fri Sep 09 00:00:00 UTC 2016
Mixed tau and TDP-43 pathology in a patient with unclassifiable primary progressive aphasia.
Neurocase
Flanagan EP,Duffy JR,Whitwell JL,Vemuri P,Dickson DW,Josephs KA
Fri Sep 09 00:00:00 UTC 2016
Global identification of hnRNP A1 binding sites for SSO-based splicing modulation.
BMC biology
Bruun GH,Doktor TK,Borch-Jensen J,Masuda A,Krainer AR,Ohno K,Andresen BS
Tue Jul 05 00:00:00 UTC 2016
Global identification of hnRNP A1 binding sites for SSO-based splicing modulation.
BMC biology
Bruun GH,Doktor TK,Borch-Jensen J,Masuda A,Krainer AR,Ohno K,Andresen BS
Tue Jul 05 00:00:00 UTC 2016
Altered localization and functionality of TAR DNA Binding Protein 43 (TDP-43) in niemann- pick disease type C.
Acta neuropathologica communications
Dardis A,Zampieri S,Canterini S,Newell KL,Stuani C,Murrell JR,Ghetti B,Fiorenza MT,Bembi B,Buratti E
Wed May 18 00:00:00 UTC 2016
Altered localization and functionality of TAR DNA Binding Protein 43 (TDP-43) in niemann- pick disease type C.
Acta neuropathologica communications
Dardis A,Zampieri S,Canterini S,Newell KL,Stuani C,Murrell JR,Ghetti B,Fiorenza MT,Bembi B,Buratti E
Wed May 18 00:00:00 UTC 2016
GRN and MAPT Mutations in 2 Frontotemporal Dementia Research Centers in Brazil.
Alzheimer disease and associated disorders
Takada LT,Bahia VS,Guimarães HC,Costa TV,Vale TC,Rodriguez RD,Porto FH,Machado JC,Beato RG,Cesar KG,Smid J,Nascimento CF,Grinberg LT,Brucki SM,Maximino JR,Camargos ST,Chadi G,Caramelli P,Nitrini R
Thu Nov 16 00:00:00 UTC 2017
The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.
Nature medicine
Wang W,Wang L,Lu J,Siedlak SL,Fujioka H,Liang J,Jiang S,Ma X,Jiang Z,da Rocha EL,Sheng M,Choi H,Lerou PH,Li H,Wang X
Mon Aug 01 00:00:00 UTC 2016
The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.
Nature medicine
Wang W,Wang L,Lu J,Siedlak SL,Fujioka H,Liang J,Jiang S,Ma X,Jiang Z,da Rocha EL,Sheng M,Choi H,Lerou PH,Li H,Wang X
Mon Aug 01 00:00:00 UTC 2016
The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.
Nature medicine
Wang W,Wang L,Lu J,Siedlak SL,Fujioka H,Liang J,Jiang S,Ma X,Jiang Z,da Rocha EL,Sheng M,Choi H,Lerou PH,Li H,Wang X
Mon Aug 01 00:00:00 UTC 2016
The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.
Nature medicine
Wang W,Wang L,Lu J,Siedlak SL,Fujioka H,Liang J,Jiang S,Ma X,Jiang Z,da Rocha EL,Sheng M,Choi H,Lerou PH,Li H,Wang X
Mon Aug 01 00:00:00 UTC 2016
The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.
Nature medicine
Wang W,Wang L,Lu J,Siedlak SL,Fujioka H,Liang J,Jiang S,Ma X,Jiang Z,da Rocha EL,Sheng M,Choi H,Lerou PH,Li H,Wang X
Mon Aug 01 00:00:00 UTC 2016
The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.
Nature medicine
Wang W,Wang L,Lu J,Siedlak SL,Fujioka H,Liang J,Jiang S,Ma X,Jiang Z,da Rocha EL,Sheng M,Choi H,Lerou PH,Li H,Wang X
Mon Aug 01 00:00:00 UTC 2016
Distinct Muscle Biopsy Findings in Genetically Defined Adult-Onset Motor Neuron Disorders.
PloS one
Jokela M,Huovinen S,Raheem O,Lindfors M,Palmio J,Penttilä S,Udd B
Thu Aug 11 00:00:00 UTC 2016
Distinct Muscle Biopsy Findings in Genetically Defined Adult-Onset Motor Neuron Disorders.
PloS one
Jokela M,Huovinen S,Raheem O,Lindfors M,Palmio J,Penttilä S,Udd B
Thu Aug 11 00:00:00 UTC 2016
Survival in the pre-senile dementia frontotemporal lobar degeneration with TDP-43 proteinopathy: effects of genetic, demographic and neuropathological variables.
Folia neuropathologica
Armstrong RA
Thu Apr 13 00:00:00 UTC 2017
Survival in the pre-senile dementia frontotemporal lobar degeneration with TDP-43 proteinopathy: effects of genetic, demographic and neuropathological variables.
Folia neuropathologica
Armstrong RA
Thu Apr 13 00:00:00 UTC 2017
Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia.
Molecular neurodegeneration
Alquezar C,Salado IG,de la Encarnación A,Pérez DI,Moreno F,Gil C,de Munain AL,Martínez A,Martín-Requero Á
Sat Apr 30 00:00:00 UTC 2016
Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia.
Molecular neurodegeneration
Alquezar C,Salado IG,de la Encarnación A,Pérez DI,Moreno F,Gil C,de Munain AL,Martínez A,Martín-Requero Á
Sat Apr 30 00:00:00 UTC 2016
Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia.
Molecular neurodegeneration
Alquezar C,Salado IG,de la Encarnación A,Pérez DI,Moreno F,Gil C,de Munain AL,Martínez A,Martín-Requero Á
Sat Apr 30 00:00:00 UTC 2016
Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia.
Molecular neurodegeneration
Alquezar C,Salado IG,de la Encarnación A,Pérez DI,Moreno F,Gil C,de Munain AL,Martínez A,Martín-Requero Á
Sat Apr 30 00:00:00 UTC 2016
Defining the spectrum of frontotemporal dementias associated with TARDBP mutations.
Neurology. Genetics
Caroppo P,Camuzat A,Guillot-Noel L,Thomas-Antérion C,Couratier P,Wong TH,Teichmann M,Golfier V,Auriacombe S,Belliard S,Laurent B,Lattante S,Millecamps S,Clot F,Dubois B,van Swieten JC,Brice A,Le Ber I
Wed Jun 01 00:00:00 UTC 2016
Familial Amyotrophic Lateral Sclerosis-linked Mutations in Profilin 1 Exacerbate TDP-43-induced Degeneration in the Retina of Drosophila melanogaster through an Increase in the Cytoplasmic Localization of TDP-43.
The Journal of biological chemistry
Matsukawa K,Hashimoto T,Matsumoto T,Ihara R,Chihara T,Miura M,Wakabayashi T,Iwatsubo T
Fri Nov 04 00:00:00 UTC 2016
Familial Amyotrophic Lateral Sclerosis-linked Mutations in Profilin 1 Exacerbate TDP-43-induced Degeneration in the Retina of Drosophila melanogaster through an Increase in the Cytoplasmic Localization of TDP-43.
The Journal of biological chemistry
Matsukawa K,Hashimoto T,Matsumoto T,Ihara R,Chihara T,Miura M,Wakabayashi T,Iwatsubo T
Fri Nov 04 00:00:00 UTC 2016
Familial Amyotrophic Lateral Sclerosis-linked Mutations in Profilin 1 Exacerbate TDP-43-induced Degeneration in the Retina of Drosophila melanogaster through an Increase in the Cytoplasmic Localization of TDP-43.
The Journal of biological chemistry
Matsukawa K,Hashimoto T,Matsumoto T,Ihara R,Chihara T,Miura M,Wakabayashi T,Iwatsubo T
Fri Nov 04 00:00:00 UTC 2016
Familial Amyotrophic Lateral Sclerosis-linked Mutations in Profilin 1 Exacerbate TDP-43-induced Degeneration in the Retina of Drosophila melanogaster through an Increase in the Cytoplasmic Localization of TDP-43.
The Journal of biological chemistry
Matsukawa K,Hashimoto T,Matsumoto T,Ihara R,Chihara T,Miura M,Wakabayashi T,Iwatsubo T
Fri Nov 04 00:00:00 UTC 2016
Familial Amyotrophic Lateral Sclerosis-linked Mutations in Profilin 1 Exacerbate TDP-43-induced Degeneration in the Retina of Drosophila melanogaster through an Increase in the Cytoplasmic Localization of TDP-43.
The Journal of biological chemistry
Matsukawa K,Hashimoto T,Matsumoto T,Ihara R,Chihara T,Miura M,Wakabayashi T,Iwatsubo T
Fri Nov 04 00:00:00 UTC 2016
Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses.
Nature communications
Kapeli K,Pratt GA,Vu AQ,Hutt KR,Martinez FJ,Sundararaman B,Batra R,Freese P,Lambert NJ,Huelga SC,Chun SJ,Liang TY,Chang J,Donohue JP,Shiue L,Zhang J,Zhu H,Cambi F,Kasarskis E,Hoon S,Ares M,Burge CB,Ravits J,Rigo F,Yeo GW
Tue Jul 05 00:00:00 UTC 2016
Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses.
Nature communications
Kapeli K,Pratt GA,Vu AQ,Hutt KR,Martinez FJ,Sundararaman B,Batra R,Freese P,Lambert NJ,Huelga SC,Chun SJ,Liang TY,Chang J,Donohue JP,Shiue L,Zhang J,Zhu H,Cambi F,Kasarskis E,Hoon S,Ares M,Burge CB,Ravits J,Rigo F,Yeo GW
Tue Jul 05 00:00:00 UTC 2016
Mechanistic Insights into Hsp104 Potentiation.
The Journal of biological chemistry
Torrente MP,Chuang E,Noll MM,Jackrel ME,Go MS,Shorter J
Fri Mar 04 00:00:00 UTC 2016
Diagnostically important muscle pathology in DNAJB6 mutated LGMD1D.
Acta neuropathologica communications
Sandell S,Huovinen S,Palmio J,Raheem O,Lindfors M,Zhao F,Haapasalo H,Udd B
Fri Feb 05 00:00:00 UTC 2016
Diagnostically important muscle pathology in DNAJB6 mutated LGMD1D.
Acta neuropathologica communications
Sandell S,Huovinen S,Palmio J,Raheem O,Lindfors M,Zhao F,Haapasalo H,Udd B
Fri Feb 05 00:00:00 UTC 2016
Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43.
The Journal of biological chemistry
Nonaka T,Suzuki G,Tanaka Y,Kametani F,Hirai S,Okado H,Miyashita T,Saitoe M,Akiyama H,Masai H,Hasegawa M
Fri Mar 11 00:00:00 UTC 2016
Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43.
The Journal of biological chemistry
Nonaka T,Suzuki G,Tanaka Y,Kametani F,Hirai S,Okado H,Miyashita T,Saitoe M,Akiyama H,Masai H,Hasegawa M
Fri Mar 11 00:00:00 UTC 2016
ALS patients with ability to communicate after long-term mechanical ventilation have confined degeneration to the motor neuron system.
Journal of the neurological sciences
Mochizuki Y,Hayashi K,Nakayama Y,Shimizu T,Kamide M,Ogino M,Komori T,Hasegawa M,Isozaki E,Nakano I
Fri Apr 15 00:00:00 UTC 2016
An autopsied case of unclassifiable sporadic four-repeat tauopathy presenting with parkinsonism and speech disturbances.
Neuropathology : official journal of the Japanese Society of Neuropathology
Iwasaki Y,Mori K,Ito M,Tatsumi S,Mimuro M,Kuwano R,Hasegawa M,Yoshida M
Wed Jun 01 00:00:00 UTC 2016
Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome.
PLoS genetics
Li R,Dong Q,Yuan X,Zeng X,Gao Y,Chiao C,Li H,Zhao X,Keles S,Wang Z,Chang Q
Wed Jun 01 00:00:00 UTC 2016
ESCRT-0 dysfunction compromises autophagic degradation of protein aggregates and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways.
Scientific reports
Oshima R,Hasegawa T,Tamai K,Sugeno N,Yoshida S,Kobayashi J,Kikuchi A,Baba T,Futatsugi A,Sato I,Satoh K,Takeda A,Aoki M,Tanaka N
Tue Apr 26 00:00:00 UTC 2016
ESCRT-0 dysfunction compromises autophagic degradation of protein aggregates and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways.
Scientific reports
Oshima R,Hasegawa T,Tamai K,Sugeno N,Yoshida S,Kobayashi J,Kikuchi A,Baba T,Futatsugi A,Sato I,Satoh K,Takeda A,Aoki M,Tanaka N
Tue Apr 26 00:00:00 UTC 2016
Mass spectrometric analysis of accumulated TDP-43 in amyotrophic lateral sclerosis brains.
Scientific reports
Kametani F,Obi T,Shishido T,Akatsu H,Murayama S,Saito Y,Yoshida M,Hasegawa M
Wed Mar 16 00:00:00 UTC 2016
Mass spectrometric analysis of accumulated TDP-43 in amyotrophic lateral sclerosis brains.
Scientific reports
Kametani F,Obi T,Shishido T,Akatsu H,Murayama S,Saito Y,Yoshida M,Hasegawa M
Wed Mar 16 00:00:00 UTC 2016
Nuclear bodies reorganize during myogenesis in vitro and are differentially disrupted by expression of FSHD-associated DUX4.
Skeletal muscle
Homma S,Beermann ML,Yu B,Boyce FM,Miller JB
Thu Dec 01 00:00:00 UTC 2016
Nuclear bodies reorganize during myogenesis in vitro and are differentially disrupted by expression of FSHD-associated DUX4.
Skeletal muscle
Homma S,Beermann ML,Yu B,Boyce FM,Miller JB
Thu Dec 01 00:00:00 UTC 2016
Intravenous injection of l-BMAA induces a rat model with comprehensive characteristics of amyotrophic lateral sclerosis/Parkinson-dementia complex.
Toxicology research
Tian KW,Jiang H,Wang BB,Zhang F,Han S
Fri Jan 01 00:00:00 UTC 2016
Reduced stress granule formation and cell death in fibroblasts with the A382T mutation of TARDBP gene: evidence for loss of TDP-43 nuclear function.
Human molecular genetics
Orrù S,Coni P,Floris A,Littera R,Carcassi C,Sogos V,Brancia C
Sat Oct 15 00:00:00 UTC 2016
Reduced stress granule formation and cell death in fibroblasts with the A382T mutation of TARDBP gene: evidence for loss of TDP-43 nuclear function.
Human molecular genetics
Orrù S,Coni P,Floris A,Littera R,Carcassi C,Sogos V,Brancia C
Sat Oct 15 00:00:00 UTC 2016
Heterogeneity of cerebral TDP-43 pathology in sporadic amyotrophic lateral sclerosis: Evidence for clinico-pathologic subtypes.
Acta neuropathologica communications
Takeuchi R,Tada M,Shiga A,Toyoshima Y,Konno T,Sato T,Nozaki H,Kato T,Horie M,Shimizu H,Takebayashi H,Onodera O,Nishizawa M,Kakita A,Takahashi H
Thu Jun 23 00:00:00 UTC 2016
CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS.
Scientific reports
Uchida T,Tamaki Y,Ayaki T,Shodai A,Kaji S,Morimura T,Banno Y,Nishitsuji K,Sakashita N,Maki T,Yamashita H,Ito H,Takahashi R,Urushitani M
Mon Jan 11 00:00:00 UTC 2016
CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS.
Scientific reports
Uchida T,Tamaki Y,Ayaki T,Shodai A,Kaji S,Morimura T,Banno Y,Nishitsuji K,Sakashita N,Maki T,Yamashita H,Ito H,Takahashi R,Urushitani M
Mon Jan 11 00:00:00 UTC 2016
CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS.
Scientific reports
Uchida T,Tamaki Y,Ayaki T,Shodai A,Kaji S,Morimura T,Banno Y,Nishitsuji K,Sakashita N,Maki T,Yamashita H,Ito H,Takahashi R,Urushitani M
Mon Jan 11 00:00:00 UTC 2016
CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS.
Scientific reports
Uchida T,Tamaki Y,Ayaki T,Shodai A,Kaji S,Morimura T,Banno Y,Nishitsuji K,Sakashita N,Maki T,Yamashita H,Ito H,Takahashi R,Urushitani M
Mon Jan 11 00:00:00 UTC 2016
CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS.
Scientific reports
Uchida T,Tamaki Y,Ayaki T,Shodai A,Kaji S,Morimura T,Banno Y,Nishitsuji K,Sakashita N,Maki T,Yamashita H,Ito H,Takahashi R,Urushitani M
Mon Jan 11 00:00:00 UTC 2016
The AMPA receptor antagonist perampanel robustly rescues amyotrophic lateral sclerosis (ALS) pathology in sporadic ALS model mice.
Scientific reports
Akamatsu M,Yamashita T,Hirose N,Teramoto S,Kwak S
Tue Jun 28 00:00:00 UTC 2016
The AMPA receptor antagonist perampanel robustly rescues amyotrophic lateral sclerosis (ALS) pathology in sporadic ALS model mice.
Scientific reports
Akamatsu M,Yamashita T,Hirose N,Teramoto S,Kwak S
Tue Jun 28 00:00:00 UTC 2016
Gene-specific mitochondria dysfunctions in human TARDBP and C9ORF72 fibroblasts.
Acta neuropathologica communications
Onesto E,Colombrita C,Gumina V,Borghi MO,Dusi S,Doretti A,Fagiolari G,Invernizzi F,Moggio M,Tiranti V,Silani V,Ratti A
Thu May 05 00:00:00 UTC 2016
Gene-specific mitochondria dysfunctions in human TARDBP and C9ORF72 fibroblasts.
Acta neuropathologica communications
Onesto E,Colombrita C,Gumina V,Borghi MO,Dusi S,Doretti A,Fagiolari G,Invernizzi F,Moggio M,Tiranti V,Silani V,Ratti A
Thu May 05 00:00:00 UTC 2016
Gene-specific mitochondria dysfunctions in human TARDBP and C9ORF72 fibroblasts.
Acta neuropathologica communications
Onesto E,Colombrita C,Gumina V,Borghi MO,Dusi S,Doretti A,Fagiolari G,Invernizzi F,Moggio M,Tiranti V,Silani V,Ratti A
Thu May 05 00:00:00 UTC 2016
Gene-specific mitochondria dysfunctions in human TARDBP and C9ORF72 fibroblasts.
Acta neuropathologica communications
Onesto E,Colombrita C,Gumina V,Borghi MO,Dusi S,Doretti A,Fagiolari G,Invernizzi F,Moggio M,Tiranti V,Silani V,Ratti A
Thu May 05 00:00:00 UTC 2016
Templated Aggregation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Seeding with TDP-43 Peptide Fibrils.
The Journal of biological chemistry
Shimonaka S,Nonaka T,Suzuki G,Hisanaga S,Hasegawa M
Fri Apr 22 00:00:00 UTC 2016
Templated Aggregation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Seeding with TDP-43 Peptide Fibrils.
The Journal of biological chemistry
Shimonaka S,Nonaka T,Suzuki G,Hisanaga S,Hasegawa M
Fri Apr 22 00:00:00 UTC 2016
Templated Aggregation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Seeding with TDP-43 Peptide Fibrils.
The Journal of biological chemistry
Shimonaka S,Nonaka T,Suzuki G,Hisanaga S,Hasegawa M
Fri Apr 22 00:00:00 UTC 2016
Templated Aggregation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Seeding with TDP-43 Peptide Fibrils.
The Journal of biological chemistry
Shimonaka S,Nonaka T,Suzuki G,Hisanaga S,Hasegawa M
Fri Apr 22 00:00:00 UTC 2016
Mutations in HSPB8 causing a new phenotype of distal myopathy and motor neuropathy.
Neurology
Ghaoui R,Palmio J,Brewer J,Lek M,Needham M,Evilä A,Hackman P,Jonson PH,Penttilä S,Vihola A,Huovinen S,Lindfors M,Davis RL,Waddell L,Kaur S,Yiannikas C,North K,Clarke N,MacArthur DG,Sue CM,Udd B
Tue Jan 26 00:00:00 UTC 2016
Detection of hyperphosphorylated tau protein and α-synuclein in spinal cord of patients with Alzheimer's disease.
Neuropsychiatric disease and treatment
Guo Y,Wang L,Zhu M,Zhang H,Hu Y,Han Z,Liu J,Zhao W,Wang D
Fri Mar 25 00:00:00 UTC 2016
A transgenic mouse expressing CHMP2Bintron5 mutant in neurons develops histological and behavioural features of amyotrophic lateral sclerosis and frontotemporal dementia.
Human molecular genetics
Vernay A,Therreau L,Blot B,Risson V,Dirrig-Grosch S,Waegaert R,Lequeu T,Sellal F,Schaeffer L,Sadoul R,Loeffler JP,René F
Mon Aug 01 00:00:00 UTC 2016
Axonal TDP-43 aggregates in sporadic amyotrophic lateral sclerosis.
Neuropathology and applied neurobiology
Onozato T,Nakahara A,Suzuki-Kouyama E,Hineno A,Yasude T,Nakamura T,Yahikozawa H,Watanabe M,Kayanuma K,Makishita H,Ohara S,Hashimoto T,Higuchi K,Sakai T,Asano K,Hashimoto T,Kanno H,Nakayama J,Oyanagi K
Sat Oct 01 00:00:00 UTC 2016
Lentiviral vector-mediated overexpression of mutant ataxin-7 recapitulates SCA7 pathology and promotes accumulation of the FUS/TLS and MBNL1 RNA-binding proteins.
Molecular neurodegeneration
Alves S,Marais T,Biferi MG,Furling D,Marinello M,El Hachimi K,Cartier N,Ruberg M,Stevanin G,Brice A,Barkats M,Sittler A
Thu Jul 28 00:00:00 UTC 2016
TDP-43 aggregation mirrors TDP-43 knockdown, affecting the expression levels of a common set of proteins.
Scientific reports
Prpar Mihevc S,Baralle M,Buratti E,Rogelj B
Mon Sep 26 00:00:00 UTC 2016
TDP-43 aggregation mirrors TDP-43 knockdown, affecting the expression levels of a common set of proteins.
Scientific reports
Prpar Mihevc S,Baralle M,Buratti E,Rogelj B
Mon Sep 26 00:00:00 UTC 2016
Neurodegeneration. C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits.
Science (New York, N.Y.)
Chew J,Gendron TF,Prudencio M,Sasaguri H,Zhang YJ,Castanedes-Casey M,Lee CW,Jansen-West K,Kurti A,Murray ME,Bieniek KF,Bauer PO,Whitelaw EC,Rousseau L,Stankowski JN,Stetler C,Daughrity LM,Perkerson EA,Desaro P,Johnston A,Overstreet K,Edbauer D,Rademakers R,Boylan KB,Dickson DW,Fryer JD,Petrucelli L
Fri Jun 05 00:00:00 UTC 2015
TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD.
Science (New York, N.Y.)
Ling JP,Pletnikova O,Troncoso JC,Wong PC
Fri Aug 07 00:00:00 UTC 2015
TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD.
Science (New York, N.Y.)
Ling JP,Pletnikova O,Troncoso JC,Wong PC
Fri Aug 07 00:00:00 UTC 2015
TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD.
Science (New York, N.Y.)
Ling JP,Pletnikova O,Troncoso JC,Wong PC
Fri Aug 07 00:00:00 UTC 2015
R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study.
JAMA neurology
Korvatska O,Leverenz JB,Jayadev S,McMillan P,Kurtz I,Guo X,Rumbaugh M,Matsushita M,Girirajan S,Dorschner MO,Kiianitsa K,Yu CE,Brkanac Z,Garden GA,Raskind WH,Bird TD
Sat Aug 01 00:00:00 UTC 2015
R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study.
JAMA neurology
Korvatska O,Leverenz JB,Jayadev S,McMillan P,Kurtz I,Guo X,Rumbaugh M,Matsushita M,Girirajan S,Dorschner MO,Kiianitsa K,Yu CE,Brkanac Z,Garden GA,Raskind WH,Bird TD
Sat Aug 01 00:00:00 UTC 2015
Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia.
Nature neuroscience
Freischmidt A,Wieland T,Richter B,Ruf W,Schaeffer V,Müller K,Marroquin N,Nordin F,Hübers A,Weydt P,Pinto S,Press R,Millecamps S,Molko N,Bernard E,Desnuelle C,Soriani MH,Dorst J,Graf E,Nordström U,Feiler MS,Putz S,Boeckers TM,Meyer T,Winkler AS,Winkelman J,de Carvalho M,Thal DR,Otto M,Brännström T,Volk AE,Kursula P,Danzer KM,Lichtner P,Dikic I,Meitinger T,Ludolph AC,Strom TM,Andersen PM,Weishaupt JH
Fri May 01 00:00:00 UTC 2015
Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia.
Nature neuroscience
Freischmidt A,Wieland T,Richter B,Ruf W,Schaeffer V,Müller K,Marroquin N,Nordin F,Hübers A,Weydt P,Pinto S,Press R,Millecamps S,Molko N,Bernard E,Desnuelle C,Soriani MH,Dorst J,Graf E,Nordström U,Feiler MS,Putz S,Boeckers TM,Meyer T,Winkler AS,Winkelman J,de Carvalho M,Thal DR,Otto M,Brännström T,Volk AE,Kursula P,Danzer KM,Lichtner P,Dikic I,Meitinger T,Ludolph AC,Strom TM,Andersen PM,Weishaupt JH
Fri May 01 00:00:00 UTC 2015
C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD.
Neuron
O'Rourke JG,Bogdanik L,Muhammad AKMG,Gendron TF,Kim KJ,Austin A,Cady J,Liu EY,Zarrow J,Grant S,Ho R,Bell S,Carmona S,Simpkinson M,Lall D,Wu K,Daughrity L,Dickson DW,Harms MB,Petrucelli L,Lee EB,Lutz CM,Baloh RH
Wed Dec 02 00:00:00 UTC 2015
C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD.
Neuron
O'Rourke JG,Bogdanik L,Muhammad AKMG,Gendron TF,Kim KJ,Austin A,Cady J,Liu EY,Zarrow J,Grant S,Ho R,Bell S,Carmona S,Simpkinson M,Lall D,Wu K,Daughrity L,Dickson DW,Harms MB,Petrucelli L,Lee EB,Lutz CM,Baloh RH
Wed Dec 02 00:00:00 UTC 2015
C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD.
Neuron
O'Rourke JG,Bogdanik L,Muhammad AKMG,Gendron TF,Kim KJ,Austin A,Cady J,Liu EY,Zarrow J,Grant S,Ho R,Bell S,Carmona S,Simpkinson M,Lall D,Wu K,Daughrity L,Dickson DW,Harms MB,Petrucelli L,Lee EB,Lutz CM,Baloh RH
Wed Dec 02 00:00:00 UTC 2015
C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD.
Neuron
O'Rourke JG,Bogdanik L,Muhammad AKMG,Gendron TF,Kim KJ,Austin A,Cady J,Liu EY,Zarrow J,Grant S,Ho R,Bell S,Carmona S,Simpkinson M,Lall D,Wu K,Daughrity L,Dickson DW,Harms MB,Petrucelli L,Lee EB,Lutz CM,Baloh RH
Wed Dec 02 00:00:00 UTC 2015
Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice.
Neuron
Peters OM,Cabrera GT,Tran H,Gendron TF,McKeon JE,Metterville J,Weiss A,Wightman N,Salameh J,Kim J,Sun H,Boylan KB,Dickson D,Kennedy Z,Lin Z,Zhang YJ,Daughrity L,Jung C,Gao FB,Sapp PC,Horvitz HR,Bosco DA,Brown SP,de Jong P,Petrucelli L,Mueller C,Brown RH
Wed Dec 02 00:00:00 UTC 2015
Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice.
Neuron
Peters OM,Cabrera GT,Tran H,Gendron TF,McKeon JE,Metterville J,Weiss A,Wightman N,Salameh J,Kim J,Sun H,Boylan KB,Dickson D,Kennedy Z,Lin Z,Zhang YJ,Daughrity L,Jung C,Gao FB,Sapp PC,Horvitz HR,Bosco DA,Brown SP,de Jong P,Petrucelli L,Mueller C,Brown RH
Wed Dec 02 00:00:00 UTC 2015
Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers.
Acta neuropathologica
Mackenzie IR,Frick P,Grässer FA,Gendron TF,Petrucelli L,Cashman NR,Edbauer D,Kremmer E,Prudlo J,Troost D,Neumann M
Tue Dec 01 00:00:00 UTC 2015
Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers.
Acta neuropathologica
Mackenzie IR,Frick P,Grässer FA,Gendron TF,Petrucelli L,Cashman NR,Edbauer D,Kremmer E,Prudlo J,Troost D,Neumann M
Tue Dec 01 00:00:00 UTC 2015
Hippocampal sclerosis in Lewy body disease is a TDP-43 proteinopathy similar to FTLD-TDP Type A.
Acta neuropathologica
Aoki N,Murray ME,Ogaki K,Fujioka S,Rutherford NJ,Rademakers R,Ross OA,Dickson DW
Thu Jan 01 00:00:00 UTC 2015
Hippocampal sclerosis in Lewy body disease is a TDP-43 proteinopathy similar to FTLD-TDP Type A.
Acta neuropathologica
Aoki N,Murray ME,Ogaki K,Fujioka S,Rutherford NJ,Rademakers R,Ross OA,Dickson DW
Thu Jan 01 00:00:00 UTC 2015
Pathogenic Ubqln2 gains toxic properties to induce neuron death.
Acta neuropathologica
Wu Q,Liu M,Huang C,Liu X,Huang B,Li N,Zhou H,Xia XG
Sun Mar 01 00:00:00 UTC 2015
Pathogenic Ubqln2 gains toxic properties to induce neuron death.
Acta neuropathologica
Wu Q,Liu M,Huang C,Liu X,Huang B,Li N,Zhou H,Xia XG
Sun Mar 01 00:00:00 UTC 2015
Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy.
Acta neuropathologica
Cooper-Knock J,Higginbottom A,Stopford MJ,Highley JR,Ince PG,Wharton SB,Pickering-Brown S,Kirby J,Hautbergue GM,Shaw PJ
Wed Jul 01 00:00:00 UTC 2015
Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy.
Acta neuropathologica
Cooper-Knock J,Higginbottom A,Stopford MJ,Highley JR,Ince PG,Wharton SB,Pickering-Brown S,Kirby J,Hautbergue GM,Shaw PJ
Wed Jul 01 00:00:00 UTC 2015
Low molecular weight species of TDP-43 generated by abnormal splicing form inclusions in amyotrophic lateral sclerosis and result in motor neuron death.
Acta neuropathologica
Xiao S,Sanelli T,Chiang H,Sun Y,Chakrabartty A,Keith J,Rogaeva E,Zinman L,Robertson J
Wed Jul 01 00:00:00 UTC 2015
Low molecular weight species of TDP-43 generated by abnormal splicing form inclusions in amyotrophic lateral sclerosis and result in motor neuron death.
Acta neuropathologica
Xiao S,Sanelli T,Chiang H,Sun Y,Chakrabartty A,Keith J,Rogaeva E,Zinman L,Robertson J
Wed Jul 01 00:00:00 UTC 2015
Low molecular weight species of TDP-43 generated by abnormal splicing form inclusions in amyotrophic lateral sclerosis and result in motor neuron death.
Acta neuropathologica
Xiao S,Sanelli T,Chiang H,Sun Y,Chakrabartty A,Keith J,Rogaeva E,Zinman L,Robertson J
Wed Jul 01 00:00:00 UTC 2015
Low molecular weight species of TDP-43 generated by abnormal splicing form inclusions in amyotrophic lateral sclerosis and result in motor neuron death.
Acta neuropathologica
Xiao S,Sanelli T,Chiang H,Sun Y,Chakrabartty A,Keith J,Rogaeva E,Zinman L,Robertson J
Wed Jul 01 00:00:00 UTC 2015
Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS.
Acta neuropathologica
Ke YD,van Hummel A,Stevens CH,Gladbach A,Ippati S,Bi M,Lee WS,Krüger S,van der Hoven J,Volkerling A,Bongers A,Halliday G,Haass NK,Kiernan M,Delerue F,Ittner LM
Sun Nov 01 00:00:00 UTC 2015
Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS.
Acta neuropathologica
Ke YD,van Hummel A,Stevens CH,Gladbach A,Ippati S,Bi M,Lee WS,Krüger S,van der Hoven J,Volkerling A,Bongers A,Halliday G,Haass NK,Kiernan M,Delerue F,Ittner LM
Sun Nov 01 00:00:00 UTC 2015
Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations.
Brain : a journal of neurology
Iovino M,Agathou S,González-Rueda A,Del Castillo Velasco-Herrera M,Borroni B,Alberici A,Lynch T,O'Dowd S,Geti I,Gaffney D,Vallier L,Paulsen O,Káradóttir RT,Spillantini MG
Sun Nov 01 00:00:00 UTC 2015
Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations.
Brain : a journal of neurology
Iovino M,Agathou S,González-Rueda A,Del Castillo Velasco-Herrera M,Borroni B,Alberici A,Lynch T,O'Dowd S,Geti I,Gaffney D,Vallier L,Paulsen O,Káradóttir RT,Spillantini MG
Sun Nov 01 00:00:00 UTC 2015
Expanding the spectrum of neuronal pathology in multiple system atrophy.
Brain : a journal of neurology
Cykowski MD,Coon EA,Powell SZ,Jenkins SM,Benarroch EE,Low PA,Schmeichel AM,Parisi JE
Sat Aug 01 00:00:00 UTC 2015
Expanding the spectrum of neuronal pathology in multiple system atrophy.
Brain : a journal of neurology
Cykowski MD,Coon EA,Powell SZ,Jenkins SM,Benarroch EE,Low PA,Schmeichel AM,Parisi JE
Sat Aug 01 00:00:00 UTC 2015
Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes.
Brain : a journal of neurology
Lauranzano E,Pozzi S,Pasetto L,Stucchi R,Massignan T,Paolella K,Mombrini M,Nardo G,Lunetta C,Corbo M,Mora G,Bendotti C,Bonetto V
Wed Apr 01 00:00:00 UTC 2015
Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes.
Brain : a journal of neurology
Lauranzano E,Pozzi S,Pasetto L,Stucchi R,Massignan T,Paolella K,Mombrini M,Nardo G,Lunetta C,Corbo M,Mora G,Bendotti C,Bonetto V
Wed Apr 01 00:00:00 UTC 2015
Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS.
The EMBO journal
Emde A,Eitan C,Liou LL,Libby RT,Rivkin N,Magen I,Reichenstein I,Oppenheim H,Eilam R,Silvestroni A,Alajajian B,Ben-Dov IZ,Aebischer J,Savidor A,Levin Y,Sons R,Hammond SM,Ravits JM,Möller T,Hornstein E
Tue Nov 03 00:00:00 UTC 2015
Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS.
The EMBO journal
Emde A,Eitan C,Liou LL,Libby RT,Rivkin N,Magen I,Reichenstein I,Oppenheim H,Eilam R,Silvestroni A,Alajajian B,Ben-Dov IZ,Aebischer J,Savidor A,Levin Y,Sons R,Hammond SM,Ravits JM,Möller T,Hornstein E
Tue Nov 03 00:00:00 UTC 2015
Spinocerebellar ataxia type 36 exists in diverse populations and can be caused by a short hexanucleotide GGCCTG repeat expansion.
Journal of neurology, neurosurgery, and psychiatry
Obayashi M,Stevanin G,Synofzik M,Monin ML,Duyckaerts C,Sato N,Streichenberger N,Vighetto A,Desestret V,Tesson C,Wichmann HE,Illig T,Huttenlocher J,Kita Y,Izumi Y,Mizusawa H,Schöls L,Klopstock T,Brice A,Ishikawa K,Dürr A
Tue Sep 01 00:00:00 UTC 2015
SQSTM1 splice site mutation in distal myopathy with rimmed vacuoles.
Neurology
Bucelli RC,Arhzaouy K,Pestronk A,Pittman SK,Rojas L,Sue CM,Evilä A,Hackman P,Udd B,Harms MB,Weihl CC
Tue Aug 25 00:00:00 UTC 2015
SQSTM1 splice site mutation in distal myopathy with rimmed vacuoles.
Neurology
Bucelli RC,Arhzaouy K,Pestronk A,Pittman SK,Rojas L,Sue CM,Evilä A,Hackman P,Udd B,Harms MB,Weihl CC
Tue Aug 25 00:00:00 UTC 2015
C9orf72 ablation in mice does not cause motor neuron degeneration or motor deficits.
Annals of neurology
Koppers M,Blokhuis AM,Westeneng HJ,Terpstra ML,Zundel CA,Vieira de Sá R,Schellevis RD,Waite AJ,Blake DJ,Veldink JH,van den Berg LH,Pasterkamp RJ
Tue Sep 01 00:00:00 UTC 2015
C9orf72 ablation in mice does not cause motor neuron degeneration or motor deficits.
Annals of neurology
Koppers M,Blokhuis AM,Westeneng HJ,Terpstra ML,Zundel CA,Vieira de Sá R,Schellevis RD,Waite AJ,Blake DJ,Veldink JH,van den Berg LH,Pasterkamp RJ
Tue Sep 01 00:00:00 UTC 2015
Defining neurodegeneration on Guam by targeted genomic sequencing.
Annals of neurology
Steele JC,Guella I,Szu-Tu C,Lin MK,Thompson C,Evans DM,Sherman HE,Vilariño-Güell C,Gwinn K,Morris H,Dickson DW,Farrer MJ
Sun Mar 01 00:00:00 UTC 2015
Defining neurodegeneration on Guam by targeted genomic sequencing.
Annals of neurology
Steele JC,Guella I,Szu-Tu C,Lin MK,Thompson C,Evans DM,Sherman HE,Vilariño-Güell C,Gwinn K,Morris H,Dickson DW,Farrer MJ
Sun Mar 01 00:00:00 UTC 2015
Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue.
Annals of neurology
Marquié M,Normandin MD,Vanderburg CR,Costantino IM,Bien EA,Rycyna LG,Klunk WE,Mathis CA,Ikonomovic MD,Debnath ML,Vasdev N,Dickerson BC,Gomperts SN,Growdon JH,Johnson KA,Frosch MP,Hyman BT,Gómez-Isla T
Sun Nov 01 00:00:00 UTC 2015
Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue.
Annals of neurology
Marquié M,Normandin MD,Vanderburg CR,Costantino IM,Bien EA,Rycyna LG,Klunk WE,Mathis CA,Ikonomovic MD,Debnath ML,Vasdev N,Dickerson BC,Gomperts SN,Growdon JH,Johnson KA,Frosch MP,Hyman BT,Gómez-Isla T
Sun Nov 01 00:00:00 UTC 2015
Age-Dependent TDP-43-Mediated Motor Neuron Degeneration Requires GSK3, hat-trick, and xmas-2.
Current biology : CB
Sreedharan J,Neukomm LJ,Brown RH,Freeman MR
Mon Aug 17 00:00:00 UTC 2015
Minimal change multiple system atrophy: an aggressive variant?
Movement disorders : official journal of the Movement Disorder Society
Ling H,Asi YT,Petrovic IN,Ahmed Z,Prashanth LK,Hazrati LN,Nishizawa M,Ozawa T,Lang A,Lees AJ,Revesz T,Holton JL
Mon Jun 01 00:00:00 UTC 2015
Minimal change multiple system atrophy: an aggressive variant?
Movement disorders : official journal of the Movement Disorder Society
Ling H,Asi YT,Petrovic IN,Ahmed Z,Prashanth LK,Hazrati LN,Nishizawa M,Ozawa T,Lang A,Lees AJ,Revesz T,Holton JL
Mon Jun 01 00:00:00 UTC 2015
G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA.
The Journal of cell biology
Aulas A,Caron G,Gkogkas CG,Mohamed NV,Destroismaisons L,Sonenberg N,Leclerc N,Parker JA,Vande Velde C
Mon Apr 13 00:00:00 UTC 2015
G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA.
The Journal of cell biology
Aulas A,Caron G,Gkogkas CG,Mohamed NV,Destroismaisons L,Sonenberg N,Leclerc N,Parker JA,Vande Velde C
Mon Apr 13 00:00:00 UTC 2015
G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA.
The Journal of cell biology
Aulas A,Caron G,Gkogkas CG,Mohamed NV,Destroismaisons L,Sonenberg N,Leclerc N,Parker JA,Vande Velde C
Mon Apr 13 00:00:00 UTC 2015
G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA.
The Journal of cell biology
Aulas A,Caron G,Gkogkas CG,Mohamed NV,Destroismaisons L,Sonenberg N,Leclerc N,Parker JA,Vande Velde C
Mon Apr 13 00:00:00 UTC 2015
TDP-43 is intercellularly transmitted across axon terminals.
The Journal of cell biology
Feiler MS,Strobel B,Freischmidt A,Helferich AM,Kappel J,Brewer BM,Li D,Thal DR,Walther P,Ludolph AC,Danzer KM,Weishaupt JH
Mon Nov 23 00:00:00 UTC 2015
TDP-43 is intercellularly transmitted across axon terminals.
The Journal of cell biology
Feiler MS,Strobel B,Freischmidt A,Helferich AM,Kappel J,Brewer BM,Li D,Thal DR,Walther P,Ludolph AC,Danzer KM,Weishaupt JH
Mon Nov 23 00:00:00 UTC 2015
TDP-43 is intercellularly transmitted across axon terminals.
The Journal of cell biology
Feiler MS,Strobel B,Freischmidt A,Helferich AM,Kappel J,Brewer BM,Li D,Thal DR,Walther P,Ludolph AC,Danzer KM,Weishaupt JH
Mon Nov 23 00:00:00 UTC 2015
TDP-43 is intercellularly transmitted across axon terminals.
The Journal of cell biology
Feiler MS,Strobel B,Freischmidt A,Helferich AM,Kappel J,Brewer BM,Li D,Thal DR,Walther P,Ludolph AC,Danzer KM,Weishaupt JH
Mon Nov 23 00:00:00 UTC 2015
TARDBP pathogenic mutations increase cytoplasmic translocation of TDP-43 and cause reduction of endoplasmic reticulum Ca²⁺ signaling in motor neurons.
Neurobiology of disease
Mutihac R,Alegre-Abarrategui J,Gordon D,Farrimond L,Yamasaki-Mann M,Talbot K,Wade-Martins R
Sun Mar 01 00:00:00 UTC 2015
TARDBP pathogenic mutations increase cytoplasmic translocation of TDP-43 and cause reduction of endoplasmic reticulum Ca²⁺ signaling in motor neurons.
Neurobiology of disease
Mutihac R,Alegre-Abarrategui J,Gordon D,Farrimond L,Yamasaki-Mann M,Talbot K,Wade-Martins R
Sun Mar 01 00:00:00 UTC 2015
Pathological features of preclinical or early clinical stages of corticobasal degeneration: a comparison with advanced cases.
Neuropathology and applied neurobiology
Nishida N,Yoshida K,Hata Y,Arai Y,Kinoshita K
Tue Dec 01 00:00:00 UTC 2015
Pathological features of preclinical or early clinical stages of corticobasal degeneration: a comparison with advanced cases.
Neuropathology and applied neurobiology
Nishida N,Yoshida K,Hata Y,Arai Y,Kinoshita K
Tue Dec 01 00:00:00 UTC 2015
Miro1 deficiency in amyotrophic lateral sclerosis.
Frontiers in aging neuroscience
Zhang F,Wang W,Siedlak SL,Liu Y,Liu J,Jiang K,Perry G,Zhu X,Wang X
Mon Jun 15 00:00:00 UTC 2015
Miro1 deficiency in amyotrophic lateral sclerosis.
Frontiers in aging neuroscience
Zhang F,Wang W,Siedlak SL,Liu Y,Liu J,Jiang K,Perry G,Zhu X,Wang X
Mon Jun 15 00:00:00 UTC 2015
G1/S Cell Cycle Checkpoint Dysfunction in Lymphoblasts from Sporadic Parkinson's Disease Patients.
Molecular neurobiology
Esteras N,Alquézar C,Bartolomé F,de la Encarnación A,Bermejo-Pareja F,Molina JA,Martín-Requero Á
Sat Aug 01 00:00:00 UTC 2015
G1/S Cell Cycle Checkpoint Dysfunction in Lymphoblasts from Sporadic Parkinson's Disease Patients.
Molecular neurobiology
Esteras N,Alquézar C,Bartolomé F,de la Encarnación A,Bermejo-Pareja F,Molina JA,Martín-Requero Á
Sat Aug 01 00:00:00 UTC 2015
G1/S Cell Cycle Checkpoint Dysfunction in Lymphoblasts from Sporadic Parkinson's Disease Patients.
Molecular neurobiology
Esteras N,Alquézar C,Bartolomé F,de la Encarnación A,Bermejo-Pareja F,Molina JA,Martín-Requero Á
Sat Aug 01 00:00:00 UTC 2015
G1/S Cell Cycle Checkpoint Dysfunction in Lymphoblasts from Sporadic Parkinson's Disease Patients.
Molecular neurobiology
Esteras N,Alquézar C,Bartolomé F,de la Encarnación A,Bermejo-Pareja F,Molina JA,Martín-Requero Á
Sat Aug 01 00:00:00 UTC 2015
Expression of FSHD-related DUX4-FL alters proteostasis and induces TDP-43 aggregation.
Annals of clinical and translational neurology
Homma S,Beermann ML,Boyce FM,Miller JB
Sun Feb 01 00:00:00 UTC 2015
Expression of FSHD-related DUX4-FL alters proteostasis and induces TDP-43 aggregation.
Annals of clinical and translational neurology
Homma S,Beermann ML,Boyce FM,Miller JB
Sun Feb 01 00:00:00 UTC 2015
Increasing progranulin levels and blockade of the ERK1/2 pathway: upstream and downstream strategies for the treatment of progranulin deficient frontotemporal dementia.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Alquezar C,Esteras N,de la Encarnación A,Moreno F,López de Munain A,Martín-Requero Á
Sun Mar 01 00:00:00 UTC 2015
Increasing progranulin levels and blockade of the ERK1/2 pathway: upstream and downstream strategies for the treatment of progranulin deficient frontotemporal dementia.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Alquezar C,Esteras N,de la Encarnación A,Moreno F,López de Munain A,Martín-Requero Á
Sun Mar 01 00:00:00 UTC 2015
Nuclear accumulation of mRNAs underlies G4C2-repeat-induced translational repression in a cellular model of C9orf72 ALS.
Journal of cell science
Rossi S,Serrano A,Gerbino V,Giorgi A,Di Francesco L,Nencini M,Bozzo F,Schininà ME,Bagni C,Cestra G,Carrì MT,Achsel T,Cozzolino M
Fri May 01 00:00:00 UTC 2015
Nuclear accumulation of mRNAs underlies G4C2-repeat-induced translational repression in a cellular model of C9orf72 ALS.
Journal of cell science
Rossi S,Serrano A,Gerbino V,Giorgi A,Di Francesco L,Nencini M,Bozzo F,Schininà ME,Bagni C,Cestra G,Carrì MT,Achsel T,Cozzolino M
Fri May 01 00:00:00 UTC 2015
Changes in TDP-43 expression in development, aging, and in the neurofilament light protein knockout mouse.
Neurobiology of aging
Liu Y,Atkinson RA,Fernandez-Martos CM,Kirkcaldie MT,Cui H,Vickers JC,King AE
Sun Feb 01 00:00:00 UTC 2015
Changes in TDP-43 expression in development, aging, and in the neurofilament light protein knockout mouse.
Neurobiology of aging
Liu Y,Atkinson RA,Fernandez-Martos CM,Kirkcaldie MT,Cui H,Vickers JC,King AE
Sun Feb 01 00:00:00 UTC 2015
Changes in TDP-43 expression in development, aging, and in the neurofilament light protein knockout mouse.
Neurobiology of aging
Liu Y,Atkinson RA,Fernandez-Martos CM,Kirkcaldie MT,Cui H,Vickers JC,King AE
Sun Feb 01 00:00:00 UTC 2015
Changes in TDP-43 expression in development, aging, and in the neurofilament light protein knockout mouse.
Neurobiology of aging
Liu Y,Atkinson RA,Fernandez-Martos CM,Kirkcaldie MT,Cui H,Vickers JC,King AE
Sun Feb 01 00:00:00 UTC 2015
Primary fibroblasts cultures reveal TDP-43 abnormalities in amyotrophic lateral sclerosis patients with and without SOD1 mutations.
Neurobiology of aging
Sabatelli M,Zollino M,Conte A,Del Grande A,Marangi G,Lucchini M,Mirabella M,Romano A,Piacentini R,Bisogni G,Lattante S,Luigetti M,Rossini PM,Moncada A
Fri May 01 00:00:00 UTC 2015
Primary fibroblasts cultures reveal TDP-43 abnormalities in amyotrophic lateral sclerosis patients with and without SOD1 mutations.
Neurobiology of aging
Sabatelli M,Zollino M,Conte A,Del Grande A,Marangi G,Lucchini M,Mirabella M,Romano A,Piacentini R,Bisogni G,Lattante S,Luigetti M,Rossini PM,Moncada A
Fri May 01 00:00:00 UTC 2015
Opposing roles of p38 and JNK in a Drosophila model of TDP-43 proteinopathy reveal oxidative stress and innate immunity as pathogenic components of neurodegeneration.
Human molecular genetics
Zhan L,Xie Q,Tibbetts RS
Sun Feb 01 00:00:00 UTC 2015
Opposing roles of p38 and JNK in a Drosophila model of TDP-43 proteinopathy reveal oxidative stress and innate immunity as pathogenic components of neurodegeneration.
Human molecular genetics
Zhan L,Xie Q,Tibbetts RS
Sun Feb 01 00:00:00 UTC 2015
Characterization of the dipeptide repeat protein in the molecular pathogenesis of c9FTD/ALS.
Human molecular genetics
Yamakawa M,Ito D,Honda T,Kubo K,Noda M,Nakajima K,Suzuki N
Sun Mar 15 00:00:00 UTC 2015
Characterization of the dipeptide repeat protein in the molecular pathogenesis of c9FTD/ALS.
Human molecular genetics
Yamakawa M,Ito D,Honda T,Kubo K,Noda M,Nakajima K,Suzuki N
Sun Mar 15 00:00:00 UTC 2015
Characterization of the dipeptide repeat protein in the molecular pathogenesis of c9FTD/ALS.
Human molecular genetics
Yamakawa M,Ito D,Honda T,Kubo K,Noda M,Nakajima K,Suzuki N
Sun Mar 15 00:00:00 UTC 2015
Characterization of the dipeptide repeat protein in the molecular pathogenesis of c9FTD/ALS.
Human molecular genetics
Yamakawa M,Ito D,Honda T,Kubo K,Noda M,Nakajima K,Suzuki N
Sun Mar 15 00:00:00 UTC 2015
Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43.
Human molecular genetics
Moujalled D,James JL,Yang S,Zhang K,Duncan C,Moujalled DM,Parker SJ,Caragounis A,Lidgerwood G,Turner BJ,Atkin JD,Grubman A,Liddell JR,Proepper C,Boeckers TM,Kanninen KM,Blair I,Crouch PJ,White AR
Sun Mar 15 00:00:00 UTC 2015
Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43.
Human molecular genetics
Moujalled D,James JL,Yang S,Zhang K,Duncan C,Moujalled DM,Parker SJ,Caragounis A,Lidgerwood G,Turner BJ,Atkin JD,Grubman A,Liddell JR,Proepper C,Boeckers TM,Kanninen KM,Blair I,Crouch PJ,White AR
Sun Mar 15 00:00:00 UTC 2015
Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43.
Human molecular genetics
Moujalled D,James JL,Yang S,Zhang K,Duncan C,Moujalled DM,Parker SJ,Caragounis A,Lidgerwood G,Turner BJ,Atkin JD,Grubman A,Liddell JR,Proepper C,Boeckers TM,Kanninen KM,Blair I,Crouch PJ,White AR
Sun Mar 15 00:00:00 UTC 2015
Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43.
Human molecular genetics
Moujalled D,James JL,Yang S,Zhang K,Duncan C,Moujalled DM,Parker SJ,Caragounis A,Lidgerwood G,Turner BJ,Atkin JD,Grubman A,Liddell JR,Proepper C,Boeckers TM,Kanninen KM,Blair I,Crouch PJ,White AR
Sun Mar 15 00:00:00 UTC 2015
Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43.
Human molecular genetics
Moujalled D,James JL,Yang S,Zhang K,Duncan C,Moujalled DM,Parker SJ,Caragounis A,Lidgerwood G,Turner BJ,Atkin JD,Grubman A,Liddell JR,Proepper C,Boeckers TM,Kanninen KM,Blair I,Crouch PJ,White AR
Sun Mar 15 00:00:00 UTC 2015
Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43.
Human molecular genetics
Moujalled D,James JL,Yang S,Zhang K,Duncan C,Moujalled DM,Parker SJ,Caragounis A,Lidgerwood G,Turner BJ,Atkin JD,Grubman A,Liddell JR,Proepper C,Boeckers TM,Kanninen KM,Blair I,Crouch PJ,White AR
Sun Mar 15 00:00:00 UTC 2015
Oxr1 improves pathogenic cellular features of ALS-associated FUS and TDP-43 mutations.
Human molecular genetics
Finelli MJ,Liu KX,Wu Y,Oliver PL,Davies KE
Mon Jun 15 00:00:00 UTC 2015
Oxr1 improves pathogenic cellular features of ALS-associated FUS and TDP-43 mutations.
Human molecular genetics
Finelli MJ,Liu KX,Wu Y,Oliver PL,Davies KE
Mon Jun 15 00:00:00 UTC 2015
Myofibrillar disruption and RNA-binding protein aggregation in a mouse model of limb-girdle muscular dystrophy 1D.
Human molecular genetics
Bengoechea R,Pittman SK,Tuck EP,True HL,Weihl CC
Tue Dec 01 00:00:00 UTC 2015
Myofibrillar disruption and RNA-binding protein aggregation in a mouse model of limb-girdle muscular dystrophy 1D.
Human molecular genetics
Bengoechea R,Pittman SK,Tuck EP,True HL,Weihl CC
Tue Dec 01 00:00:00 UTC 2015
TDP-43 loss of cellular function through aggregation requires additional structural determinants beyond its C-terminal Q/N prion-like domain.
Human molecular genetics
Budini M,Romano V,Quadri Z,Buratti E,Baralle FE
Thu Jan 01 00:00:00 UTC 2015
TDP-43 loss of cellular function through aggregation requires additional structural determinants beyond its C-terminal Q/N prion-like domain.
Human molecular genetics
Budini M,Romano V,Quadri Z,Buratti E,Baralle FE
Thu Jan 01 00:00:00 UTC 2015
TDP-43 loss of cellular function through aggregation requires additional structural determinants beyond its C-terminal Q/N prion-like domain.
Human molecular genetics
Budini M,Romano V,Quadri Z,Buratti E,Baralle FE
Thu Jan 01 00:00:00 UTC 2015
TDP-43 loss of cellular function through aggregation requires additional structural determinants beyond its C-terminal Q/N prion-like domain.
Human molecular genetics
Budini M,Romano V,Quadri Z,Buratti E,Baralle FE
Thu Jan 01 00:00:00 UTC 2015
Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs.
Human molecular genetics
Suzuki H,Shibagaki Y,Hattori S,Matsuoka M
Sun Mar 15 00:00:00 UTC 2015
Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs.
Human molecular genetics
Suzuki H,Shibagaki Y,Hattori S,Matsuoka M
Sun Mar 15 00:00:00 UTC 2015
Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs.
Human molecular genetics
Suzuki H,Shibagaki Y,Hattori S,Matsuoka M
Sun Mar 15 00:00:00 UTC 2015
Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs.
Human molecular genetics
Suzuki H,Shibagaki Y,Hattori S,Matsuoka M
Sun Mar 15 00:00:00 UTC 2015
PABPN1 suppresses TDP-43 toxicity in ALS disease models.
Human molecular genetics
Chou CC,Alexeeva OM,Yamada S,Pribadi A,Zhang Y,Mo B,Williams KR,Zarnescu DC,Rossoll W
Tue Sep 15 00:00:00 UTC 2015
PABPN1 suppresses TDP-43 toxicity in ALS disease models.
Human molecular genetics
Chou CC,Alexeeva OM,Yamada S,Pribadi A,Zhang Y,Mo B,Williams KR,Zarnescu DC,Rossoll W
Tue Sep 15 00:00:00 UTC 2015
Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity.
Human molecular genetics
Tao Z,Wang H,Xia Q,Li K,Li K,Jiang X,Xu G,Wang G,Ying Z
Fri May 01 00:00:00 UTC 2015
Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity.
Human molecular genetics
Tao Z,Wang H,Xia Q,Li K,Li K,Jiang X,Xu G,Wang G,Ying Z
Fri May 01 00:00:00 UTC 2015
Identification of linc-NeD125, a novel long non coding RNA that hosts miR-125b-1 and negatively controls proliferation of human neuroblastoma cells.
RNA biology
Bevilacqua V,Gioia U,Di Carlo V,Tortorelli AF,Colombo T,Bozzoni I,Laneve P,Caffarelli E
Wed Oct 12 00:00:00 UTC 2016
Identification of linc-NeD125, a novel long non coding RNA that hosts miR-125b-1 and negatively controls proliferation of human neuroblastoma cells.
RNA biology
Bevilacqua V,Gioia U,Di Carlo V,Tortorelli AF,Colombo T,Bozzoni I,Laneve P,Caffarelli E
Wed Oct 12 00:00:00 UTC 2016
Disparate Mutations Confer Therapeutic Gain of Hsp104 Function.
ACS chemical biology
Jackrel ME,Yee K,Tariq A,Chen AI,Shorter J
Fri Dec 18 00:00:00 UTC 2015
A Peruvian family with a novel PARK2 mutation: Clinical and pathological characteristics.
Parkinsonism & related disorders
Cornejo-Olivas MR,Torres L,Mata IF,Mazzetti P,Rivas D,Cosentino C,Inca-Martinez M,Cuba JM,Zabetian CP,Leverenz JB
Fri May 01 00:00:00 UTC 2015
A Peruvian family with a novel PARK2 mutation: Clinical and pathological characteristics.
Parkinsonism & related disorders
Cornejo-Olivas MR,Torres L,Mata IF,Mazzetti P,Rivas D,Cosentino C,Inca-Martinez M,Cuba JM,Zabetian CP,Leverenz JB
Fri May 01 00:00:00 UTC 2015
Analysis of β-N-methylamino-L-alanine (L-BMAA) neurotoxicity in rat cerebellum.
Neurotoxicology
Muñoz-Sáez E,de Munck García E,Arahuetes Portero RM,Martínez A,Solas Alados MT,Miguel BG
Fri May 01 00:00:00 UTC 2015
Analysis of β-N-methylamino-L-alanine (L-BMAA) neurotoxicity in rat cerebellum.
Neurotoxicology
Muñoz-Sáez E,de Munck García E,Arahuetes Portero RM,Martínez A,Solas Alados MT,Miguel BG
Fri May 01 00:00:00 UTC 2015
Analysis of β-N-methylamino-L-alanine (L-BMAA) neurotoxicity in rat cerebellum.
Neurotoxicology
Muñoz-Sáez E,de Munck García E,Arahuetes Portero RM,Martínez A,Solas Alados MT,Miguel BG
Fri May 01 00:00:00 UTC 2015
Analysis of β-N-methylamino-L-alanine (L-BMAA) neurotoxicity in rat cerebellum.
Neurotoxicology
Muñoz-Sáez E,de Munck García E,Arahuetes Portero RM,Martínez A,Solas Alados MT,Miguel BG
Fri May 01 00:00:00 UTC 2015
Evaluation of Skin Fibroblasts from Amyotrophic Lateral Sclerosis Patients for the Rapid Study of Pathological Features.
Neurotoxicity research
Yang S,Zhang KY,Kariawasam R,Bax M,Fifita JA,Ooi L,Yerbury JJ,Nicholson GA,Blair IP
Sat Aug 01 00:00:00 UTC 2015
Evaluation of Skin Fibroblasts from Amyotrophic Lateral Sclerosis Patients for the Rapid Study of Pathological Features.
Neurotoxicity research
Yang S,Zhang KY,Kariawasam R,Bax M,Fifita JA,Ooi L,Yerbury JJ,Nicholson GA,Blair IP
Sat Aug 01 00:00:00 UTC 2015
Identification of transactivation-responsive DNA-binding protein 43 (TARDBP43; TDP-43) as a novel factor for TNF-α expression upon lipopolysaccharide stimulation in human monocytes.
Journal of periodontal research
Murata H,Hattori T,Maeda H,Takashiba S,Takigawa M,Kido J,Nagata T
Sat Aug 01 00:00:00 UTC 2015
Identification of transactivation-responsive DNA-binding protein 43 (TARDBP43; TDP-43) as a novel factor for TNF-α expression upon lipopolysaccharide stimulation in human monocytes.
Journal of periodontal research
Murata H,Hattori T,Maeda H,Takashiba S,Takigawa M,Kido J,Nagata T
Sat Aug 01 00:00:00 UTC 2015
Identification of transactivation-responsive DNA-binding protein 43 (TARDBP43; TDP-43) as a novel factor for TNF-α expression upon lipopolysaccharide stimulation in human monocytes.
Journal of periodontal research
Murata H,Hattori T,Maeda H,Takashiba S,Takigawa M,Kido J,Nagata T
Sat Aug 01 00:00:00 UTC 2015
Identification of transactivation-responsive DNA-binding protein 43 (TARDBP43; TDP-43) as a novel factor for TNF-α expression upon lipopolysaccharide stimulation in human monocytes.
Journal of periodontal research
Murata H,Hattori T,Maeda H,Takashiba S,Takigawa M,Kido J,Nagata T
Sat Aug 01 00:00:00 UTC 2015
Identification of transactivation-responsive DNA-binding protein 43 (TARDBP43; TDP-43) as a novel factor for TNF-α expression upon lipopolysaccharide stimulation in human monocytes.
Journal of periodontal research
Murata H,Hattori T,Maeda H,Takashiba S,Takigawa M,Kido J,Nagata T
Sat Aug 01 00:00:00 UTC 2015
Identification of transactivation-responsive DNA-binding protein 43 (TARDBP43; TDP-43) as a novel factor for TNF-α expression upon lipopolysaccharide stimulation in human monocytes.
Journal of periodontal research
Murata H,Hattori T,Maeda H,Takashiba S,Takigawa M,Kido J,Nagata T
Sat Aug 01 00:00:00 UTC 2015
Traumatic brain injury causes frontotemporal dementia and TDP-43 proteolysis.
Neuroscience
Wang HK,Lee YC,Huang CY,Liliang PC,Lu K,Chen HJ,Li YC,Tsai KJ
Thu Aug 06 00:00:00 UTC 2015
Traumatic brain injury causes frontotemporal dementia and TDP-43 proteolysis.
Neuroscience
Wang HK,Lee YC,Huang CY,Liliang PC,Lu K,Chen HJ,Li YC,Tsai KJ
Thu Aug 06 00:00:00 UTC 2015
Proteomic analyses reveal that loss of TDP-43 affects RNA processing and intracellular transport.
Neuroscience
Štalekar M,Yin X,Rebolj K,Darovic S,Troakes C,Mayr M,Shaw CE,Rogelj B
Thu May 07 00:00:00 UTC 2015
Proteomic analyses reveal that loss of TDP-43 affects RNA processing and intracellular transport.
Neuroscience
Štalekar M,Yin X,Rebolj K,Darovic S,Troakes C,Mayr M,Shaw CE,Rogelj B
Thu May 07 00:00:00 UTC 2015
Proteomic analyses reveal that loss of TDP-43 affects RNA processing and intracellular transport.
Neuroscience
Štalekar M,Yin X,Rebolj K,Darovic S,Troakes C,Mayr M,Shaw CE,Rogelj B
Thu May 07 00:00:00 UTC 2015
Proteomic analyses reveal that loss of TDP-43 affects RNA processing and intracellular transport.
Neuroscience
Štalekar M,Yin X,Rebolj K,Darovic S,Troakes C,Mayr M,Shaw CE,Rogelj B
Thu May 07 00:00:00 UTC 2015
An age-related reduction of brain TBPH/TDP-43 levels precedes the onset of locomotion defects in a Drosophila ALS model.
Neuroscience
Cragnaz L,Klima R,De Conti L,Romano G,Feiguin F,Buratti E,Baralle M,Baralle FE
Thu Dec 17 00:00:00 UTC 2015
An age-related reduction of brain TBPH/TDP-43 levels precedes the onset of locomotion defects in a Drosophila ALS model.
Neuroscience
Cragnaz L,Klima R,De Conti L,Romano G,Feiguin F,Buratti E,Baralle M,Baralle FE
Thu Dec 17 00:00:00 UTC 2015
An optimized InCell Western screening technique identifies hexachlorophene as a novel potent TDP43 targeting drug.
Journal of biotechnology
Narayan M,Peralta DA,Gibson C,Zitnyar A,Jinwal UK
Mon Aug 10 00:00:00 UTC 2015
An optimized InCell Western screening technique identifies hexachlorophene as a novel potent TDP43 targeting drug.
Journal of biotechnology
Narayan M,Peralta DA,Gibson C,Zitnyar A,Jinwal UK
Mon Aug 10 00:00:00 UTC 2015
4-Hydroxynonenal induces persistent insolubilization of TDP-43 and alters its intracellular localization.
Biochemical and biophysical research communications
Kabuta C,Kono K,Wada K,Kabuta T
Mon Aug 24 00:00:00 UTC 2015
A phosphomimetic mutant TDP-43 (S409/410E) induces Drosha instability and cytotoxicity in Neuro 2A cells.
Biochemical and biophysical research communications
Kim KY,Lee HW,Shim YM,Mook-Jung I,Jeon GS,Sung JJ
Fri Aug 14 00:00:00 UTC 2015
A phosphomimetic mutant TDP-43 (S409/410E) induces Drosha instability and cytotoxicity in Neuro 2A cells.
Biochemical and biophysical research communications
Kim KY,Lee HW,Shim YM,Mook-Jung I,Jeon GS,Sung JJ
Fri Aug 14 00:00:00 UTC 2015
Amyotrophic lateral sclerosis-associated mutant profilin 1 increases dendritic arborisation and spine formation in primary hippocampal neurons.
Neuroscience letters
Brettle M,Suchowerska AK,Chua SW,Ittner LM,Fath T
Mon Nov 16 00:00:00 UTC 2015
Amyotrophic lateral sclerosis-associated mutant profilin 1 increases dendritic arborisation and spine formation in primary hippocampal neurons.
Neuroscience letters
Brettle M,Suchowerska AK,Chua SW,Ittner LM,Fath T
Mon Nov 16 00:00:00 UTC 2015
Neuropathologic features of suicide victims who presented with acute poststroke depression: significance of association with neurodegenerative disorders.
Journal of neuropathology and experimental neurology
Nishida N,Hata Y,Yoshida K,Kinoshita K
Fri May 01 00:00:00 UTC 2015
Neuropathologic features of suicide victims who presented with acute poststroke depression: significance of association with neurodegenerative disorders.
Journal of neuropathology and experimental neurology
Nishida N,Hata Y,Yoshida K,Kinoshita K
Fri May 01 00:00:00 UTC 2015
TDP-43 modification in the hSOD1(G93A) amyotrophic lateral sclerosis mouse model.
Neurological research
Cai M,Lee KW,Choi SM,Yang EJ
Sun Mar 01 00:00:00 UTC 2015
TDP-43 modification in the hSOD1(G93A) amyotrophic lateral sclerosis mouse model.
Neurological research
Cai M,Lee KW,Choi SM,Yang EJ
Sun Mar 01 00:00:00 UTC 2015
TDP-43 modification in the hSOD1(G93A) amyotrophic lateral sclerosis mouse model.
Neurological research
Cai M,Lee KW,Choi SM,Yang EJ
Sun Mar 01 00:00:00 UTC 2015
TDP-43 modification in the hSOD1(G93A) amyotrophic lateral sclerosis mouse model.
Neurological research
Cai M,Lee KW,Choi SM,Yang EJ
Sun Mar 01 00:00:00 UTC 2015
Hippocampal sclerosis in the parkinsonism-dementia complex of Guam: quantitative examination of neurons, neurofibrillary tangles, and TDP-43 immunoreactivity in CA1.
Neuropathology : official journal of the Japanese Society of Neuropathology
Oyanagi K,Yamazaki M,Hashimoto T,Asakawa M,Wakabayashi K,Takahashi H
Mon Jun 01 00:00:00 UTC 2015
Hippocampal sclerosis in the parkinsonism-dementia complex of Guam: quantitative examination of neurons, neurofibrillary tangles, and TDP-43 immunoreactivity in CA1.
Neuropathology : official journal of the Japanese Society of Neuropathology
Oyanagi K,Yamazaki M,Hashimoto T,Asakawa M,Wakabayashi K,Takahashi H
Mon Jun 01 00:00:00 UTC 2015
Initial gene vector dosing for studying symptomatology of amyotrophic lateral sclerosis in non-human primates.
Journal of medical primatology
Jackson KL,Dayton RD,Fisher-Perkins JM,Didier PJ,Baker KC,Weimer M,Gutierrez A,Cain CD,Mathis JM,Gitcho MA,Bunnell BA,Klein RL
Wed Apr 01 00:00:00 UTC 2015
Initial gene vector dosing for studying symptomatology of amyotrophic lateral sclerosis in non-human primates.
Journal of medical primatology
Jackson KL,Dayton RD,Fisher-Perkins JM,Didier PJ,Baker KC,Weimer M,Gutierrez A,Cain CD,Mathis JM,Gitcho MA,Bunnell BA,Klein RL
Wed Apr 01 00:00:00 UTC 2015
Initial gene vector dosing for studying symptomatology of amyotrophic lateral sclerosis in non-human primates.
Journal of medical primatology
Jackson KL,Dayton RD,Fisher-Perkins JM,Didier PJ,Baker KC,Weimer M,Gutierrez A,Cain CD,Mathis JM,Gitcho MA,Bunnell BA,Klein RL
Wed Apr 01 00:00:00 UTC 2015
Initial gene vector dosing for studying symptomatology of amyotrophic lateral sclerosis in non-human primates.
Journal of medical primatology
Jackson KL,Dayton RD,Fisher-Perkins JM,Didier PJ,Baker KC,Weimer M,Gutierrez A,Cain CD,Mathis JM,Gitcho MA,Bunnell BA,Klein RL
Wed Apr 01 00:00:00 UTC 2015
Progressive supranuclear palsy in a family with TDP-43 pathology.
Neurocase
Kertesz A,Finger E,Murrell J,Chertkow H,Ang LC,Baker M,Ravenscroft T,Rademakers R,Munoz DG
Thu Dec 17 00:00:00 UTC 2015
Progressive supranuclear palsy in a family with TDP-43 pathology.
Neurocase
Kertesz A,Finger E,Murrell J,Chertkow H,Ang LC,Baker M,Ravenscroft T,Rademakers R,Munoz DG
Thu Dec 17 00:00:00 UTC 2015
A novel mutation P112H in the TARDBP gene associated with frontotemporal lobar degeneration without motor neuron disease and abundant neuritic amyloid plaques.
Acta neuropathologica communications
Moreno F,Rabinovici GD,Karydas A,Miller Z,Hsu SC,Legati A,Fong J,Schonhaut D,Esselmann H,Watson C,Stephens ML,Kramer J,Wiltfang J,Seeley WW,Miller BL,Coppola G,Grinberg LT
Fri Apr 03 00:00:00 UTC 2015
A novel mutation P112H in the TARDBP gene associated with frontotemporal lobar degeneration without motor neuron disease and abundant neuritic amyloid plaques.
Acta neuropathologica communications
Moreno F,Rabinovici GD,Karydas A,Miller Z,Hsu SC,Legati A,Fong J,Schonhaut D,Esselmann H,Watson C,Stephens ML,Kramer J,Wiltfang J,Seeley WW,Miller BL,Coppola G,Grinberg LT
Fri Apr 03 00:00:00 UTC 2015
Exposure to ALS-FTD-CSF generates TDP-43 aggregates in glioblastoma cells through exosomes and TNTs-like structure.
Oncotarget
Ding X,Ma M,Teng J,Teng RK,Zhou S,Yin J,Fonkem E,Huang JH,Wu E,Wang X
Tue Sep 15 00:00:00 UTC 2015
Exposure to ALS-FTD-CSF generates TDP-43 aggregates in glioblastoma cells through exosomes and TNTs-like structure.
Oncotarget
Ding X,Ma M,Teng J,Teng RK,Zhou S,Yin J,Fonkem E,Huang JH,Wu E,Wang X
Tue Sep 15 00:00:00 UTC 2015
Neurodegeneration in C. elegans models of ALS requires TIR-1/Sarm1 immune pathway activation in neurons.
Nature communications
Vérièpe J,Fossouo L,Parker JA
Wed Jun 10 00:00:00 UTC 2015
Neurodegeneration in C. elegans models of ALS requires TIR-1/Sarm1 immune pathway activation in neurons.
Nature communications
Vérièpe J,Fossouo L,Parker JA
Wed Jun 10 00:00:00 UTC 2015
Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions.
Scientific reports
Farrawell NE,Lambert-Smith IA,Warraich ST,Blair IP,Saunders DN,Hatters DM,Yerbury JJ
Fri Aug 21 00:00:00 UTC 2015
Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions.
Scientific reports
Farrawell NE,Lambert-Smith IA,Warraich ST,Blair IP,Saunders DN,Hatters DM,Yerbury JJ
Fri Aug 21 00:00:00 UTC 2015
TDP-43 Inhibits NF-κB Activity by Blocking p65 Nuclear Translocation.
PloS one
Zhu J,Cynader MS,Jia W
Tue Jun 21 00:00:00 UTC 2016
TDP-43 Inhibits NF-κB Activity by Blocking p65 Nuclear Translocation.
PloS one
Zhu J,Cynader MS,Jia W
Tue Jun 21 00:00:00 UTC 2016
TDP-43 Inhibits NF-κB Activity by Blocking p65 Nuclear Translocation.
PloS one
Zhu J,Cynader MS,Jia W
Tue Jun 21 00:00:00 UTC 2016
TDP-43 Inhibits NF-κB Activity by Blocking p65 Nuclear Translocation.
PloS one
Zhu J,Cynader MS,Jia W
Tue Jun 21 00:00:00 UTC 2016
From transcriptomic to protein level changes in TDP-43 and FUS loss-of-function cell models.
Biochimica et biophysica acta
Colombrita C,Onesto E,Buratti E,de la Grange P,Gumina V,Baralle FE,Silani V,Ratti A
Tue Dec 01 00:00:00 UTC 2015
From transcriptomic to protein level changes in TDP-43 and FUS loss-of-function cell models.
Biochimica et biophysica acta
Colombrita C,Onesto E,Buratti E,de la Grange P,Gumina V,Baralle FE,Silani V,Ratti A
Tue Dec 01 00:00:00 UTC 2015
From transcriptomic to protein level changes in TDP-43 and FUS loss-of-function cell models.
Biochimica et biophysica acta
Colombrita C,Onesto E,Buratti E,de la Grange P,Gumina V,Baralle FE,Silani V,Ratti A
Tue Dec 01 00:00:00 UTC 2015
From transcriptomic to protein level changes in TDP-43 and FUS loss-of-function cell models.
Biochimica et biophysica acta
Colombrita C,Onesto E,Buratti E,de la Grange P,Gumina V,Baralle FE,Silani V,Ratti A
Tue Dec 01 00:00:00 UTC 2015
Novel atomic force microscopy based biopanning for isolation of morphology specific reagents against TDP-43 variants in amyotrophic lateral sclerosis.
Journal of visualized experiments : JoVE
Williams SM,Venkataraman L,Tian H,Khan G,Harris BT,Sierks MR
Thu Feb 12 00:00:00 UTC 2015
Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS.
Acta neuropathologica communications
Mitchell JC,Constable R,So E,Vance C,Scotter E,Glover L,Hortobagyi T,Arnold ES,Ling SC,McAlonis M,Da Cruz S,Polymenidou M,Tessarolo L,Cleveland DW,Shaw CE
Thu Jun 25 00:00:00 UTC 2015
Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS.
Acta neuropathologica communications
Mitchell JC,Constable R,So E,Vance C,Scotter E,Glover L,Hortobagyi T,Arnold ES,Ling SC,McAlonis M,Da Cruz S,Polymenidou M,Tessarolo L,Cleveland DW,Shaw CE
Thu Jun 25 00:00:00 UTC 2015
Primary chronic traumatic encephalopathy in an older patient with late-onset AD phenotype.
Neurology. Clinical practice
Fredericks CA,Koestler M,Seeley W,Miller B,Boxer A,Grinberg LT
Tue Dec 01 00:00:00 UTC 2015
Neuropathologic analysis of Tyr69His TTR variant meningovascular amyloidosis with dementia.
Acta neuropathologica communications
Ziskin JL,Greicius MD,Zhu W,Okumu AN,Adams CM,Plowey ED
Fri Jul 10 00:00:00 UTC 2015
Neuropathologic analysis of Tyr69His TTR variant meningovascular amyloidosis with dementia.
Acta neuropathologica communications
Ziskin JL,Greicius MD,Zhu W,Okumu AN,Adams CM,Plowey ED
Fri Jul 10 00:00:00 UTC 2015
TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies.
Acta neuropathologica communications
Goossens J,Vanmechelen E,Trojanowski JQ,Lee VM,Van Broeckhoven C,van der Zee J,Engelborghs S
Wed Apr 01 00:00:00 UTC 2015
TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies.
Acta neuropathologica communications
Goossens J,Vanmechelen E,Trojanowski JQ,Lee VM,Van Broeckhoven C,van der Zee J,Engelborghs S
Wed Apr 01 00:00:00 UTC 2015
An acetylation switch controls TDP-43 function and aggregation propensity.
Nature communications
Cohen TJ,Hwang AW,Restrepo CR,Yuan CX,Trojanowski JQ,Lee VM
Mon Jan 05 00:00:00 UTC 2015
An acetylation switch controls TDP-43 function and aggregation propensity.
Nature communications
Cohen TJ,Hwang AW,Restrepo CR,Yuan CX,Trojanowski JQ,Lee VM
Mon Jan 05 00:00:00 UTC 2015
An acetylation switch controls TDP-43 function and aggregation propensity.
Nature communications
Cohen TJ,Hwang AW,Restrepo CR,Yuan CX,Trojanowski JQ,Lee VM
Mon Jan 05 00:00:00 UTC 2015
An acetylation switch controls TDP-43 function and aggregation propensity.
Nature communications
Cohen TJ,Hwang AW,Restrepo CR,Yuan CX,Trojanowski JQ,Lee VM
Mon Jan 05 00:00:00 UTC 2015
An acetylation switch controls TDP-43 function and aggregation propensity.
Nature communications
Cohen TJ,Hwang AW,Restrepo CR,Yuan CX,Trojanowski JQ,Lee VM
Mon Jan 05 00:00:00 UTC 2015
Ubiquilin-2 drives NF-κB activity and cytosolic TDP-43 aggregation in neuronal cells.
Molecular brain
Picher-Martel V,Dutta K,Phaneuf D,Sobue G,Julien JP
Sat Oct 31 00:00:00 UTC 2015
Ubiquilin-2 drives NF-κB activity and cytosolic TDP-43 aggregation in neuronal cells.
Molecular brain
Picher-Martel V,Dutta K,Phaneuf D,Sobue G,Julien JP
Sat Oct 31 00:00:00 UTC 2015
Ubiquilin-2 drives NF-κB activity and cytosolic TDP-43 aggregation in neuronal cells.
Molecular brain
Picher-Martel V,Dutta K,Phaneuf D,Sobue G,Julien JP
Sat Oct 31 00:00:00 UTC 2015
Ubiquilin-2 drives NF-κB activity and cytosolic TDP-43 aggregation in neuronal cells.
Molecular brain
Picher-Martel V,Dutta K,Phaneuf D,Sobue G,Julien JP
Sat Oct 31 00:00:00 UTC 2015
Inflammation Induces TDP-43 Mislocalization and Aggregation.
PloS one
Correia AS,Patel P,Dutta K,Julien JP
Tue Jun 07 00:00:00 UTC 2016
Inflammation Induces TDP-43 Mislocalization and Aggregation.
PloS one
Correia AS,Patel P,Dutta K,Julien JP
Tue Jun 07 00:00:00 UTC 2016
Inflammation Induces TDP-43 Mislocalization and Aggregation.
PloS one
Correia AS,Patel P,Dutta K,Julien JP
Tue Jun 07 00:00:00 UTC 2016
Inflammation Induces TDP-43 Mislocalization and Aggregation.
PloS one
Correia AS,Patel P,Dutta K,Julien JP
Tue Jun 07 00:00:00 UTC 2016
Inflammation Induces TDP-43 Mislocalization and Aggregation.
PloS one
Correia AS,Patel P,Dutta K,Julien JP
Tue Jun 07 00:00:00 UTC 2016
Inflammation Induces TDP-43 Mislocalization and Aggregation.
PloS one
Correia AS,Patel P,Dutta K,Julien JP
Tue Jun 07 00:00:00 UTC 2016
Complete loss of the DNAJB6 G/F domain and novel missense mutations cause distal-onset DNAJB6 myopathy.
Acta neuropathologica communications
Ruggieri A,Brancati F,Zanotti S,Maggi L,Pasanisi MB,Saredi S,Terracciano C,Antozzi C,D Apice MR,Sangiuolo F,Novelli G,Marshall CR,Scherer SW,Morandi L,Federici L,Massa R,Mora M,Minassian BA
Sat Jul 25 00:00:00 UTC 2015
Complete loss of the DNAJB6 G/F domain and novel missense mutations cause distal-onset DNAJB6 myopathy.
Acta neuropathologica communications
Ruggieri A,Brancati F,Zanotti S,Maggi L,Pasanisi MB,Saredi S,Terracciano C,Antozzi C,D Apice MR,Sangiuolo F,Novelli G,Marshall CR,Scherer SW,Morandi L,Federici L,Massa R,Mora M,Minassian BA
Sat Jul 25 00:00:00 UTC 2015
A novel triple repeat mutant tau transgenic model that mimics aspects of pick's disease and fronto-temporal tauopathies.
PloS one
Rockenstein E,Overk CR,Ubhi K,Mante M,Patrick C,Adame A,Bisquert A,Trejo-Morales M,Spencer B,Masliah E
Mon Feb 22 00:00:00 UTC 2016
A novel triple repeat mutant tau transgenic model that mimics aspects of pick's disease and fronto-temporal tauopathies.
PloS one
Rockenstein E,Overk CR,Ubhi K,Mante M,Patrick C,Adame A,Bisquert A,Trejo-Morales M,Spencer B,Masliah E
Mon Feb 22 00:00:00 UTC 2016
Stress Granules Modulate SYK to Cause Microglial Cell Dysfunction in Alzheimer's Disease.
EBioMedicine
Ghosh S,Geahlen RL
Sun Nov 01 00:00:00 UTC 2015
Stress Granules Modulate SYK to Cause Microglial Cell Dysfunction in Alzheimer's Disease.
EBioMedicine
Ghosh S,Geahlen RL
Sun Nov 01 00:00:00 UTC 2015
The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity.
Nature communications
Li Q,Yokoshi M,Okada H,Kawahara Y
Thu Jan 29 00:00:00 UTC 2015
The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity.
Nature communications
Li Q,Yokoshi M,Okada H,Kawahara Y
Thu Jan 29 00:00:00 UTC 2015
The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity.
Nature communications
Li Q,Yokoshi M,Okada H,Kawahara Y
Thu Jan 29 00:00:00 UTC 2015
The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity.
Nature communications
Li Q,Yokoshi M,Okada H,Kawahara Y
Thu Jan 29 00:00:00 UTC 2015
Saccadic Palsy following Cardiac Surgery: Possible Role of Perineuronal Nets.
PloS one
Eggers SD,Horn AK,Roeber S,Härtig W,Nair G,Reich DS,Leigh RJ
Tue May 03 00:00:00 UTC 2016
Saccadic Palsy following Cardiac Surgery: Possible Role of Perineuronal Nets.
PloS one
Eggers SD,Horn AK,Roeber S,Härtig W,Nair G,Reich DS,Leigh RJ
Tue May 03 00:00:00 UTC 2016
Proteins with Intrinsically Disordered Domains Are Preferentially Recruited to Polyglutamine Aggregates.
PloS one
Wear MP,Kryndushkin D,O'Meally R,Sonnenberg JL,Cole RN,Shewmaker FP
Wed May 11 00:00:00 UTC 2016
Proteins with Intrinsically Disordered Domains Are Preferentially Recruited to Polyglutamine Aggregates.
PloS one
Wear MP,Kryndushkin D,O'Meally R,Sonnenberg JL,Cole RN,Shewmaker FP
Wed May 11 00:00:00 UTC 2016
Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium.
Journal of neural transmission (Vienna, Austria : 1996)
Alafuzoff I,Pikkarainen M,Neumann M,Arzberger T,Al-Sarraj S,Bodi I,Bogdanovic N,Bugiani O,Ferrer I,Gelpi E,Gentleman S,Giaccone G,Graeber MB,Hortobagyi T,Ince PG,Ironside JW,Kavantzas N,King A,Korkolopoulou P,Kovács GG,Meyronet D,Monoranu C,Nilsson T,Parchi P,Patsouris E,Revesz T,Roggendorf W,Rozemuller A,Seilhean D,Streichenberger N,Thal DR,Wharton SB,Kretzschmar H
Wed Jul 01 00:00:00 UTC 2015
Spread of pathology in amyotrophic lateral sclerosis: assessment of phosphorylated TDP-43 along axonal pathways.
Acta neuropathologica communications
Fatima M,Tan R,Halliday GM,Kril JJ
Tue Jul 28 00:00:00 UTC 2015
Spread of pathology in amyotrophic lateral sclerosis: assessment of phosphorylated TDP-43 along axonal pathways.
Acta neuropathologica communications
Fatima M,Tan R,Halliday GM,Kril JJ
Tue Jul 28 00:00:00 UTC 2015
FUS/TLS deficiency causes behavioral and pathological abnormalities distinct from amyotrophic lateral sclerosis.
Acta neuropathologica communications
Kino Y,Washizu C,Kurosawa M,Yamada M,Miyazaki H,Akagi T,Hashikawa T,Doi H,Takumi T,Hicks GG,Hattori N,Shimogori T,Nukina N
Sat Apr 25 00:00:00 UTC 2015
FUS/TLS deficiency causes behavioral and pathological abnormalities distinct from amyotrophic lateral sclerosis.
Acta neuropathologica communications
Kino Y,Washizu C,Kurosawa M,Yamada M,Miyazaki H,Akagi T,Hashikawa T,Doi H,Takumi T,Hicks GG,Hattori N,Shimogori T,Nukina N
Sat Apr 25 00:00:00 UTC 2015
AAV9 supports wide-scale transduction of the CNS and TDP-43 disease modeling in adult rats.
Molecular therapy. Methods & clinical development
Jackson KL,Dayton RD,Klein RL
Thu Oct 08 00:00:00 UTC 2015
AAV9 supports wide-scale transduction of the CNS and TDP-43 disease modeling in adult rats.
Molecular therapy. Methods & clinical development
Jackson KL,Dayton RD,Klein RL
Thu Oct 08 00:00:00 UTC 2015
Atypical association of semantic dementia, corticobasal syndrome, and 4R tauopathy.
Neurocase
Clerc MT,Deprez M,Leuba G,Lhermitte B,Lopez U,von Gunten A
Sun Feb 01 00:00:00 UTC 2015
Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events.
Cell
Jackrel ME,DeSantis ME,Martinez BA,Castellano LM,Stewart RM,Caldwell KA,Caldwell GA,Shorter J
Thu Jan 16 00:00:00 UTC 2014
Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events.
Cell
Jackrel ME,DeSantis ME,Martinez BA,Castellano LM,Stewart RM,Caldwell KA,Caldwell GA,Shorter J
Thu Jan 16 00:00:00 UTC 2014
Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models.
Nature genetics
Kim HJ,Raphael AR,LaDow ES,McGurk L,Weber RA,Trojanowski JQ,Lee VM,Finkbeiner S,Gitler AD,Bonini NM
Sat Feb 01 00:00:00 UTC 2014
Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models.
Nature genetics
Kim HJ,Raphael AR,LaDow ES,McGurk L,Weber RA,Trojanowski JQ,Lee VM,Finkbeiner S,Gitler AD,Bonini NM
Sat Feb 01 00:00:00 UTC 2014
Lower motor neuron involvement in TAR DNA-binding protein of 43 kDa-related frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
JAMA neurology
Riku Y,Watanabe H,Yoshida M,Tatsumi S,Mimuro M,Iwasaki Y,Katsuno M,Iguchi Y,Masuda M,Senda J,Ishigaki S,Udagawa T,Sobue G
Sat Feb 01 00:00:00 UTC 2014
Lower motor neuron involvement in TAR DNA-binding protein of 43 kDa-related frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
JAMA neurology
Riku Y,Watanabe H,Yoshida M,Tatsumi S,Mimuro M,Iwasaki Y,Katsuno M,Iguchi Y,Masuda M,Senda J,Ishigaki S,Udagawa T,Sobue G
Sat Feb 01 00:00:00 UTC 2014
Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis.
Nature neuroscience
Johnson JO,Pioro EP,Boehringer A,Chia R,Feit H,Renton AE,Pliner HA,Abramzon Y,Marangi G,Winborn BJ,Gibbs JR,Nalls MA,Morgan S,Shoai M,Hardy J,Pittman A,Orrell RW,Malaspina A,Sidle KC,Fratta P,Harms MB,Baloh RH,Pestronk A,Weihl CC,Rogaeva E,Zinman L,Drory VE,Borghero G,Mora G,Calvo A,Rothstein JD,Drepper C,Sendtner M,Singleton AB,Taylor JP,Cookson MR,Restagno G,Sabatelli M,Bowser R,Chiò A,Traynor BJ
Thu May 01 00:00:00 UTC 2014
Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis.
Nature neuroscience
Johnson JO,Pioro EP,Boehringer A,Chia R,Feit H,Renton AE,Pliner HA,Abramzon Y,Marangi G,Winborn BJ,Gibbs JR,Nalls MA,Morgan S,Shoai M,Hardy J,Pittman A,Orrell RW,Malaspina A,Sidle KC,Fratta P,Harms MB,Baloh RH,Pestronk A,Weihl CC,Rogaeva E,Zinman L,Drory VE,Borghero G,Mora G,Calvo A,Rothstein JD,Drepper C,Sendtner M,Singleton AB,Taylor JP,Cookson MR,Restagno G,Sabatelli M,Bowser R,Chiò A,Traynor BJ
Thu May 01 00:00:00 UTC 2014
Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis.
Nature neuroscience
Johnson JO,Pioro EP,Boehringer A,Chia R,Feit H,Renton AE,Pliner HA,Abramzon Y,Marangi G,Winborn BJ,Gibbs JR,Nalls MA,Morgan S,Shoai M,Hardy J,Pittman A,Orrell RW,Malaspina A,Sidle KC,Fratta P,Harms MB,Baloh RH,Pestronk A,Weihl CC,Rogaeva E,Zinman L,Drory VE,Borghero G,Mora G,Calvo A,Rothstein JD,Drepper C,Sendtner M,Singleton AB,Taylor JP,Cookson MR,Restagno G,Sabatelli M,Bowser R,Chiò A,Traynor BJ
Thu May 01 00:00:00 UTC 2014
Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis.
Nature neuroscience
Johnson JO,Pioro EP,Boehringer A,Chia R,Feit H,Renton AE,Pliner HA,Abramzon Y,Marangi G,Winborn BJ,Gibbs JR,Nalls MA,Morgan S,Shoai M,Hardy J,Pittman A,Orrell RW,Malaspina A,Sidle KC,Fratta P,Harms MB,Baloh RH,Pestronk A,Weihl CC,Rogaeva E,Zinman L,Drory VE,Borghero G,Mora G,Calvo A,Rothstein JD,Drepper C,Sendtner M,Singleton AB,Taylor JP,Cookson MR,Restagno G,Sabatelli M,Bowser R,Chiò A,Traynor BJ
Thu May 01 00:00:00 UTC 2014
Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.
The Journal of experimental medicine
Ward ME,Taubes A,Chen R,Miller BL,Sephton CF,Gelfand JM,Minami S,Boscardin J,Martens LH,Seeley WW,Yu G,Herz J,Filiano AJ,Arrant AE,Roberson ED,Kraft TW,Farese RV,Green A,Gan L
Mon Sep 22 00:00:00 UTC 2014
Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.
The Journal of experimental medicine
Ward ME,Taubes A,Chen R,Miller BL,Sephton CF,Gelfand JM,Minami S,Boscardin J,Martens LH,Seeley WW,Yu G,Herz J,Filiano AJ,Arrant AE,Roberson ED,Kraft TW,Farese RV,Green A,Gan L
Mon Sep 22 00:00:00 UTC 2014
Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.
The Journal of experimental medicine
Ward ME,Taubes A,Chen R,Miller BL,Sephton CF,Gelfand JM,Minami S,Boscardin J,Martens LH,Seeley WW,Yu G,Herz J,Filiano AJ,Arrant AE,Roberson ED,Kraft TW,Farese RV,Green A,Gan L
Mon Sep 22 00:00:00 UTC 2014
Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.
The Journal of experimental medicine
Ward ME,Taubes A,Chen R,Miller BL,Sephton CF,Gelfand JM,Minami S,Boscardin J,Martens LH,Seeley WW,Yu G,Herz J,Filiano AJ,Arrant AE,Roberson ED,Kraft TW,Farese RV,Green A,Gan L
Mon Sep 22 00:00:00 UTC 2014
Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.
Nature chemical biology
Barmada SJ,Serio A,Arjun A,Bilican B,Daub A,Ando DM,Tsvetkov A,Pleiss M,Li X,Peisach D,Shaw C,Chandran S,Finkbeiner S
Fri Aug 01 00:00:00 UTC 2014
Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.
Nature chemical biology
Barmada SJ,Serio A,Arjun A,Bilican B,Daub A,Ando DM,Tsvetkov A,Pleiss M,Li X,Peisach D,Shaw C,Chandran S,Finkbeiner S
Fri Aug 01 00:00:00 UTC 2014
Staging TDP-43 pathology in Alzheimer's disease.
Acta neuropathologica
Josephs KA,Murray ME,Whitwell JL,Parisi JE,Petrucelli L,Jack CR,Petersen RC,Dickson DW
Sat Mar 01 00:00:00 UTC 2014
Staging TDP-43 pathology in Alzheimer's disease.
Acta neuropathologica
Josephs KA,Murray ME,Whitwell JL,Parisi JE,Petrucelli L,Jack CR,Petersen RC,Dickson DW
Sat Mar 01 00:00:00 UTC 2014
Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis.
Acta neuropathologica
Götzl JK,Mori K,Damme M,Fellerer K,Tahirovic S,Kleinberger G,Janssens J,van der Zee J,Lang CM,Kremmer E,Martin JJ,Engelborghs S,Kretzschmar HA,Arzberger T,Van Broeckhoven C,Haass C,Capell A
Thu Aug 20 00:00:00 UTC 2015
Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis.
Acta neuropathologica
Götzl JK,Mori K,Damme M,Fellerer K,Tahirovic S,Kleinberger G,Janssens J,van der Zee J,Lang CM,Kremmer E,Martin JJ,Engelborghs S,Kretzschmar HA,Arzberger T,Van Broeckhoven C,Haass C,Capell A
Thu Aug 20 00:00:00 UTC 2015
Early dipeptide repeat pathology in a frontotemporal dementia kindred with C9ORF72 mutation and intellectual disability.
Acta neuropathologica
Proudfoot M,Gutowski NJ,Edbauer D,Hilton DA,Stephens M,Rankin J,Mackenzie IR
Sat Mar 01 00:00:00 UTC 2014
Early dipeptide repeat pathology in a frontotemporal dementia kindred with C9ORF72 mutation and intellectual disability.
Acta neuropathologica
Proudfoot M,Gutowski NJ,Edbauer D,Hilton DA,Stephens M,Rankin J,Mackenzie IR
Sat Mar 01 00:00:00 UTC 2014
Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions.
Brain : a journal of neurology
Cooper-Knock J,Walsh MJ,Higginbottom A,Robin Highley J,Dickman MJ,Edbauer D,Ince PG,Wharton SB,Wilson SA,Kirby J,Hautbergue GM,Shaw PJ
Tue Jul 01 00:00:00 UTC 2014
Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions.
Brain : a journal of neurology
Cooper-Knock J,Walsh MJ,Higginbottom A,Robin Highley J,Dickman MJ,Edbauer D,Ince PG,Wharton SB,Wilson SA,Kirby J,Hautbergue GM,Shaw PJ
Tue Jul 01 00:00:00 UTC 2014
PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology.
Brain : a journal of neurology
Wong TH,Chiu WZ,Breedveld GJ,Li KW,Verkerk AJ,Hondius D,Hukema RK,Seelaar H,Frick P,Severijnen LA,Lammers GJ,Lebbink JH,van Duinen SG,Kamphorst W,Rozemuller AJ,Bakker EB,Neumann M,Willemsen R,Bonifati V,Smit AB,van Swieten J
Thu May 01 00:00:00 UTC 2014
PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology.
Brain : a journal of neurology
Wong TH,Chiu WZ,Breedveld GJ,Li KW,Verkerk AJ,Hondius D,Hukema RK,Seelaar H,Frick P,Severijnen LA,Lammers GJ,Lebbink JH,van Duinen SG,Kamphorst W,Rozemuller AJ,Bakker EB,Neumann M,Willemsen R,Bonifati V,Smit AB,van Swieten J
Thu May 01 00:00:00 UTC 2014
New criteria for frontotemporal dementia syndromes: clinical and pathological diagnostic implications.
Journal of neurology, neurosurgery, and psychiatry
Chare L,Hodges JR,Leyton CE,McGinley C,Tan RH,Kril JJ,Halliday GM
Fri Aug 01 00:00:00 UTC 2014
New criteria for frontotemporal dementia syndromes: clinical and pathological diagnostic implications.
Journal of neurology, neurosurgery, and psychiatry
Chare L,Hodges JR,Leyton CE,McGinley C,Tan RH,Kril JJ,Halliday GM
Fri Aug 01 00:00:00 UTC 2014
Plasma phosphorylated TDP-43 levels are elevated in patients with frontotemporal dementia carrying a C9orf72 repeat expansion or a GRN mutation.
Journal of neurology, neurosurgery, and psychiatry
Suárez-Calvet M,Dols-Icardo O,Lladó A,Sánchez-Valle R,Hernández I,Amer G,Antón-Aguirre S,Alcolea D,Fortea J,Ferrer I,van der Zee J,Dillen L,Van Broeckhoven C,Molinuevo JL,Blesa R,Clarimón J,Lleó A
Sun Jun 01 00:00:00 UTC 2014
Plasma phosphorylated TDP-43 levels are elevated in patients with frontotemporal dementia carrying a C9orf72 repeat expansion or a GRN mutation.
Journal of neurology, neurosurgery, and psychiatry
Suárez-Calvet M,Dols-Icardo O,Lladó A,Sánchez-Valle R,Hernández I,Amer G,Antón-Aguirre S,Alcolea D,Fortea J,Ferrer I,van der Zee J,Dillen L,Van Broeckhoven C,Molinuevo JL,Blesa R,Clarimón J,Lleó A
Sun Jun 01 00:00:00 UTC 2014
Hereditary myopathy with early respiratory failure: occurrence in various populations.
Journal of neurology, neurosurgery, and psychiatry
Palmio J,Evilä A,Chapon F,Tasca G,Xiang F,Brådvik B,Eymard B,Echaniz-Laguna A,Laporte J,Kärppä M,Mahjneh I,Quinlivan R,Laforêt P,Damian M,Berardo A,Taratuto AL,Bueri JA,Tommiska J,Raivio T,Tuerk M,Gölitz P,Chevessier F,Sewry C,Norwood F,Hedberg C,Schröder R,Edström L,Oldfors A,Hackman P,Udd B
Sat Mar 01 00:00:00 UTC 2014
Hereditary myopathy with early respiratory failure: occurrence in various populations.
Journal of neurology, neurosurgery, and psychiatry
Palmio J,Evilä A,Chapon F,Tasca G,Xiang F,Brådvik B,Eymard B,Echaniz-Laguna A,Laporte J,Kärppä M,Mahjneh I,Quinlivan R,Laforêt P,Damian M,Berardo A,Taratuto AL,Bueri JA,Tommiska J,Raivio T,Tuerk M,Gölitz P,Chevessier F,Sewry C,Norwood F,Hedberg C,Schröder R,Edström L,Oldfors A,Hackman P,Udd B
Sat Mar 01 00:00:00 UTC 2014
Diagnosis and management of behavioral variant frontotemporal dementia.
Biological psychiatry
Pressman PS,Miller BL
Tue Apr 01 00:00:00 UTC 2014
Diagnosis and management of behavioral variant frontotemporal dementia.
Biological psychiatry
Pressman PS,Miller BL
Tue Apr 01 00:00:00 UTC 2014
Partial deletion of AFG3L2 causing spinocerebellar ataxia type 28.
Neurology
Smets K,Deconinck T,Baets J,Sieben A,Martin JJ,Smouts I,Wang S,Taroni F,Di Bella D,Van Hecke W,Parizel PM,Jadoul C,De Potter R,Couvreur F,Rugarli E,De Jonghe P
Tue Jun 10 00:00:00 UTC 2014
Partial deletion of AFG3L2 causing spinocerebellar ataxia type 28.
Neurology
Smets K,Deconinck T,Baets J,Sieben A,Martin JJ,Smouts I,Wang S,Taroni F,Di Bella D,Van Hecke W,Parizel PM,Jadoul C,De Potter R,Couvreur F,Rugarli E,De Jonghe P
Tue Jun 10 00:00:00 UTC 2014
Neuropathological features of multiple system atrophy with cognitive impairment.
Movement disorders : official journal of the Movement Disorder Society
Asi YT,Ling H,Ahmed Z,Lees AJ,Revesz T,Holton JL
Sun Jun 01 00:00:00 UTC 2014
Neuropathological features of multiple system atrophy with cognitive impairment.
Movement disorders : official journal of the Movement Disorder Society
Asi YT,Ling H,Ahmed Z,Lees AJ,Revesz T,Holton JL
Sun Jun 01 00:00:00 UTC 2014
Neuropathologic assessment of dementia markers in identical and fraternal twins.
Brain pathology (Zurich, Switzerland)
Iacono D,Volkman I,Nennesmo I,Pedersen NL,Fratiglioni L,Johansson B,Karlsson D,Winblad B,Gatz M
Tue Jul 01 00:00:00 UTC 2014
Neuropathologic assessment of dementia markers in identical and fraternal twins.
Brain pathology (Zurich, Switzerland)
Iacono D,Volkman I,Nennesmo I,Pedersen NL,Fratiglioni L,Johansson B,Karlsson D,Winblad B,Gatz M
Tue Jul 01 00:00:00 UTC 2014
TAR DNA-binding protein 43 pathology in Alzheimer's disease with psychosis.
International psychogeriatrics
Vatsavayi AV,Kofler J,Demichele-Sweet MA,Murray PS,Lopez OL,Sweet RA
Sun Jun 01 00:00:00 UTC 2014
Tar DNA-binding protein-43 (TDP-43) regulates axon growth in vitro and in vivo.
Neurobiology of disease
Tripathi VB,Baskaran P,Shaw CE,Guthrie S
Thu May 01 00:00:00 UTC 2014
Tar DNA-binding protein-43 (TDP-43) regulates axon growth in vitro and in vivo.
Neurobiology of disease
Tripathi VB,Baskaran P,Shaw CE,Guthrie S
Thu May 01 00:00:00 UTC 2014
Tar DNA-binding protein-43 (TDP-43) regulates axon growth in vitro and in vivo.
Neurobiology of disease
Tripathi VB,Baskaran P,Shaw CE,Guthrie S
Thu May 01 00:00:00 UTC 2014
Dual vulnerability of TDP-43 to calpain and caspase-3 proteolysis after neurotoxic conditions and traumatic brain injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Yang Z,Lin F,Robertson CS,Wang KK
Mon Sep 01 00:00:00 UTC 2014
Dual vulnerability of TDP-43 to calpain and caspase-3 proteolysis after neurotoxic conditions and traumatic brain injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Yang Z,Lin F,Robertson CS,Wang KK
Mon Sep 01 00:00:00 UTC 2014
Dual vulnerability of TDP-43 to calpain and caspase-3 proteolysis after neurotoxic conditions and traumatic brain injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Yang Z,Lin F,Robertson CS,Wang KK
Mon Sep 01 00:00:00 UTC 2014
Dual vulnerability of TDP-43 to calpain and caspase-3 proteolysis after neurotoxic conditions and traumatic brain injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Yang Z,Lin F,Robertson CS,Wang KK
Mon Sep 01 00:00:00 UTC 2014
FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damage.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Deng Q,Holler CJ,Taylor G,Hudson KF,Watkins W,Gearing M,Ito D,Murray ME,Dickson DW,Seyfried NT,Kukar T
Wed Jun 04 00:00:00 UTC 2014
FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damage.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Deng Q,Holler CJ,Taylor G,Hudson KF,Watkins W,Gearing M,Ito D,Murray ME,Dickson DW,Seyfried NT,Kukar T
Wed Jun 04 00:00:00 UTC 2014
Brain injection of α-synuclein induces multiple proteinopathies, gliosis, and a neuronal injury marker.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sacino AN,Brooks M,McKinney AB,Thomas MA,Shaw G,Golde TE,Giasson BI
Wed Sep 10 00:00:00 UTC 2014
Brain injection of α-synuclein induces multiple proteinopathies, gliosis, and a neuronal injury marker.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sacino AN,Brooks M,McKinney AB,Thomas MA,Shaw G,Golde TE,Giasson BI
Wed Sep 10 00:00:00 UTC 2014
Astrocytic TDP-43 pathology in Alexander disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Walker AK,Daniels CM,Goldman JE,Trojanowski JQ,Lee VM,Messing A
Wed May 07 00:00:00 UTC 2014
Astrocytic TDP-43 pathology in Alexander disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Walker AK,Daniels CM,Goldman JE,Trojanowski JQ,Lee VM,Messing A
Wed May 07 00:00:00 UTC 2014
TDP-43 toxicity proceeds via calcium dysregulation and necrosis in aging Caenorhabditis elegans motor neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Aggad D,Vérièpe J,Tauffenberger A,Parker JA
Wed Sep 03 00:00:00 UTC 2014
TDP-43 toxicity proceeds via calcium dysregulation and necrosis in aging Caenorhabditis elegans motor neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Aggad D,Vérièpe J,Tauffenberger A,Parker JA
Wed Sep 03 00:00:00 UTC 2014
ALS-linked mutations enlarge TDP-43-enriched neuronal RNA granules in the dendritic arbor.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Liu-Yesucevitz L,Lin AY,Ebata A,Boon JY,Reid W,Xu YF,Kobrin K,Murphy GJ,Petrucelli L,Wolozin B
Wed Mar 19 00:00:00 UTC 2014
ALS-linked mutations enlarge TDP-43-enriched neuronal RNA granules in the dendritic arbor.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Liu-Yesucevitz L,Lin AY,Ebata A,Boon JY,Reid W,Xu YF,Kobrin K,Murphy GJ,Petrucelli L,Wolozin B
Wed Mar 19 00:00:00 UTC 2014
Concomitant accumulation of α-synuclein and TDP-43 in a patient with corticobasal degeneration.
Journal of neurology
Yamashita S,Sakashita N,Yamashita T,Tawara N,Tasaki M,Kawakami K,Komohara Y,Fujiwara Y,Kamikawa M,Nakagawa T,Hirano T,Maeda Y,Hasegawa M,Takeya M,Ando Y
Sat Nov 01 00:00:00 UTC 2014
Concomitant accumulation of α-synuclein and TDP-43 in a patient with corticobasal degeneration.
Journal of neurology
Yamashita S,Sakashita N,Yamashita T,Tawara N,Tasaki M,Kawakami K,Komohara Y,Fujiwara Y,Kamikawa M,Nakagawa T,Hirano T,Maeda Y,Hasegawa M,Takeya M,Ando Y
Sat Nov 01 00:00:00 UTC 2014
Concomitant accumulation of α-synuclein and TDP-43 in a patient with corticobasal degeneration.
Journal of neurology
Yamashita S,Sakashita N,Yamashita T,Tawara N,Tasaki M,Kawakami K,Komohara Y,Fujiwara Y,Kamikawa M,Nakagawa T,Hirano T,Maeda Y,Hasegawa M,Takeya M,Ando Y
Sat Nov 01 00:00:00 UTC 2014
De novo prion aggregates trigger autophagy in skeletal muscle.
Journal of virology
Joshi-Barr S,Bett C,Chiang WC,Trejo M,Goebel HH,Sikorska B,Liberski P,Raeber A,Lin JH,Masliah E,Sigurdson CJ
Sat Feb 01 00:00:00 UTC 2014
De novo prion aggregates trigger autophagy in skeletal muscle.
Journal of virology
Joshi-Barr S,Bett C,Chiang WC,Trejo M,Goebel HH,Sikorska B,Liberski P,Raeber A,Lin JH,Masliah E,Sigurdson CJ
Sat Feb 01 00:00:00 UTC 2014
De novo prion aggregates trigger autophagy in skeletal muscle.
Journal of virology
Joshi-Barr S,Bett C,Chiang WC,Trejo M,Goebel HH,Sikorska B,Liberski P,Raeber A,Lin JH,Masliah E,Sigurdson CJ
Sat Feb 01 00:00:00 UTC 2014
De novo prion aggregates trigger autophagy in skeletal muscle.
Journal of virology
Joshi-Barr S,Bett C,Chiang WC,Trejo M,Goebel HH,Sikorska B,Liberski P,Raeber A,Lin JH,Masliah E,Sigurdson CJ
Sat Feb 01 00:00:00 UTC 2014
No interaction between tau and TDP-43 pathologies in either frontotemporal lobar degeneration or motor neurone disease.
Neuropathology and applied neurobiology
Robinson AC,Thompson JC,Weedon L,Rollinson S,Pickering-Brown S,Snowden JS,Davidson YS,Mann DM
Mon Dec 01 00:00:00 UTC 2014
No interaction between tau and TDP-43 pathologies in either frontotemporal lobar degeneration or motor neurone disease.
Neuropathology and applied neurobiology
Robinson AC,Thompson JC,Weedon L,Rollinson S,Pickering-Brown S,Snowden JS,Davidson YS,Mann DM
Mon Dec 01 00:00:00 UTC 2014
Loss of nuclear TDP-43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones.
Neuropathology and applied neurobiology
Highley JR,Kirby J,Jansweijer JA,Webb PS,Hewamadduma CA,Heath PR,Higginbottom A,Raman R,Ferraiuolo L,Cooper-Knock J,McDermott CJ,Wharton SB,Shaw PJ,Ince PG
Wed Oct 01 00:00:00 UTC 2014
Loss of nuclear TDP-43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones.
Neuropathology and applied neurobiology
Highley JR,Kirby J,Jansweijer JA,Webb PS,Hewamadduma CA,Heath PR,Higginbottom A,Raman R,Ferraiuolo L,Cooper-Knock J,McDermott CJ,Wharton SB,Shaw PJ,Ince PG
Wed Oct 01 00:00:00 UTC 2014
Loss of nuclear TDP-43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones.
Neuropathology and applied neurobiology
Highley JR,Kirby J,Jansweijer JA,Webb PS,Hewamadduma CA,Heath PR,Higginbottom A,Raman R,Ferraiuolo L,Cooper-Knock J,McDermott CJ,Wharton SB,Shaw PJ,Ince PG
Wed Oct 01 00:00:00 UTC 2014
Loss of nuclear TDP-43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones.
Neuropathology and applied neurobiology
Highley JR,Kirby J,Jansweijer JA,Webb PS,Hewamadduma CA,Heath PR,Higginbottom A,Raman R,Ferraiuolo L,Cooper-Knock J,McDermott CJ,Wharton SB,Shaw PJ,Ince PG
Wed Oct 01 00:00:00 UTC 2014
FUS colocalizes with polyglutamine, but not with TDP-43 in neuronal intranuclear inclusions in spinocerebellar ataxia type 2.
Neuropathology and applied neurobiology
Mori F,Toyoshima Y,Tanji K,Kakita A,Takahashi H,Wakabayashi K
Tue Apr 01 00:00:00 UTC 2014
Argyrophilic grain disease as a neurodegenerative substrate in late-onset schizophrenia and delusional disorders.
European archives of psychiatry and clinical neuroscience
Nagao S,Yokota O,Ikeda C,Takeda N,Ishizu H,Kuroda S,Sudo K,Terada S,Murayama S,Uchitomi Y
Sun Jun 01 00:00:00 UTC 2014
Argyrophilic grain disease as a neurodegenerative substrate in late-onset schizophrenia and delusional disorders.
European archives of psychiatry and clinical neuroscience
Nagao S,Yokota O,Ikeda C,Takeda N,Ishizu H,Kuroda S,Sudo K,Terada S,Murayama S,Uchitomi Y
Sun Jun 01 00:00:00 UTC 2014
Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins.
Disease models & mechanisms
Jackrel ME,Shorter J
Wed Oct 01 00:00:00 UTC 2014
Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins.
Disease models & mechanisms
Jackrel ME,Shorter J
Wed Oct 01 00:00:00 UTC 2014
Increased metal content in the TDP-43(A315T) transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Frontiers in aging neuroscience
Dang TN,Lim NK,Grubman A,Li QX,Volitakis I,White AR,Crouch PJ
Thu Feb 27 00:00:00 UTC 2014
Increased metal content in the TDP-43(A315T) transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Frontiers in aging neuroscience
Dang TN,Lim NK,Grubman A,Li QX,Volitakis I,White AR,Crouch PJ
Thu Feb 27 00:00:00 UTC 2014
Intrathecal infusion of BMAA induces selective motor neuron damage and astrogliosis in the ventral horn of the spinal cord.
Experimental neurology
Yin HZ,Yu S,Hsu CI,Liu J,Acab A,Wu R,Tao A,Chiang BJ,Weiss JH
Sat Nov 01 00:00:00 UTC 2014
Intrathecal infusion of BMAA induces selective motor neuron damage and astrogliosis in the ventral horn of the spinal cord.
Experimental neurology
Yin HZ,Yu S,Hsu CI,Liu J,Acab A,Wu R,Tao A,Chiang BJ,Weiss JH
Sat Nov 01 00:00:00 UTC 2014
ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress.
Experimental neurology
McLean JR,Smith GA,Rocha EM,Osborn TM,Dib S,Hayes MA,Beagan JA,Brown TB,Lawson TF,Hallett PJ,Robertson J,Isacson O
Sat Nov 01 00:00:00 UTC 2014
ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress.
Experimental neurology
McLean JR,Smith GA,Rocha EM,Osborn TM,Dib S,Hayes MA,Beagan JA,Brown TB,Lawson TF,Hallett PJ,Robertson J,Isacson O
Sat Nov 01 00:00:00 UTC 2014
ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress.
Experimental neurology
McLean JR,Smith GA,Rocha EM,Osborn TM,Dib S,Hayes MA,Beagan JA,Brown TB,Lawson TF,Hallett PJ,Robertson J,Isacson O
Sat Nov 01 00:00:00 UTC 2014
ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress.
Experimental neurology
McLean JR,Smith GA,Rocha EM,Osborn TM,Dib S,Hayes MA,Beagan JA,Brown TB,Lawson TF,Hallett PJ,Robertson J,Isacson O
Sat Nov 01 00:00:00 UTC 2014
The voltage-gated calcium channel blocker lomerizine is neuroprotective in motor neurons expressing mutant SOD1, but not TDP-43.
Journal of neurochemistry
Tran LT,Gentil BJ,Sullivan KE,Durham HD
Fri Aug 01 00:00:00 UTC 2014
The voltage-gated calcium channel blocker lomerizine is neuroprotective in motor neurons expressing mutant SOD1, but not TDP-43.
Journal of neurochemistry
Tran LT,Gentil BJ,Sullivan KE,Durham HD
Fri Aug 01 00:00:00 UTC 2014
The voltage-gated calcium channel blocker lomerizine is neuroprotective in motor neurons expressing mutant SOD1, but not TDP-43.
Journal of neurochemistry
Tran LT,Gentil BJ,Sullivan KE,Durham HD
Fri Aug 01 00:00:00 UTC 2014
Parkin reverses TDP-43-induced cell death and failure of amino acid homeostasis.
Journal of neurochemistry
Hebron M,Chen W,Miessau MJ,Lonskaya I,Moussa CE
Tue Apr 01 00:00:00 UTC 2014
Parkin reverses TDP-43-induced cell death and failure of amino acid homeostasis.
Journal of neurochemistry
Hebron M,Chen W,Miessau MJ,Lonskaya I,Moussa CE
Tue Apr 01 00:00:00 UTC 2014
Proteasome dysfunction induces muscle growth defects and protein aggregation.
Journal of cell science
Kitajima Y,Tashiro Y,Suzuki N,Warita H,Kato M,Tateyama M,Ando R,Izumi R,Yamazaki M,Abe M,Sakimura K,Ito H,Urushitani M,Nagatomi R,Takahashi R,Aoki M
Mon Dec 15 00:00:00 UTC 2014
Proteasome dysfunction induces muscle growth defects and protein aggregation.
Journal of cell science
Kitajima Y,Tashiro Y,Suzuki N,Warita H,Kato M,Tateyama M,Ando R,Izumi R,Yamazaki M,Abe M,Sakimura K,Ito H,Urushitani M,Nagatomi R,Takahashi R,Aoki M
Mon Dec 15 00:00:00 UTC 2014
Proteasome dysfunction induces muscle growth defects and protein aggregation.
Journal of cell science
Kitajima Y,Tashiro Y,Suzuki N,Warita H,Kato M,Tateyama M,Ando R,Izumi R,Yamazaki M,Abe M,Sakimura K,Ito H,Urushitani M,Nagatomi R,Takahashi R,Aoki M
Mon Dec 15 00:00:00 UTC 2014
Proteasome dysfunction induces muscle growth defects and protein aggregation.
Journal of cell science
Kitajima Y,Tashiro Y,Suzuki N,Warita H,Kato M,Tateyama M,Ando R,Izumi R,Yamazaki M,Abe M,Sakimura K,Ito H,Urushitani M,Nagatomi R,Takahashi R,Aoki M
Mon Dec 15 00:00:00 UTC 2014
Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species.
Journal of cell science
Scotter EL,Vance C,Nishimura AL,Lee YB,Chen HJ,Urwin H,Sardone V,Mitchell JC,Rogelj B,Rubinsztein DC,Shaw CE
Sat Mar 15 00:00:00 UTC 2014
Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species.
Journal of cell science
Scotter EL,Vance C,Nishimura AL,Lee YB,Chen HJ,Urwin H,Sardone V,Mitchell JC,Rogelj B,Rubinsztein DC,Shaw CE
Sat Mar 15 00:00:00 UTC 2014
Metabolism and mis-metabolism of the neuropathological signature protein TDP-43.
Journal of cell science
Huang CC,Bose JK,Majumder P,Lee KH,Huang JT,Huang JK,Shen CK
Tue Jul 15 00:00:00 UTC 2014
Metabolism and mis-metabolism of the neuropathological signature protein TDP-43.
Journal of cell science
Huang CC,Bose JK,Majumder P,Lee KH,Huang JT,Huang JK,Shen CK
Tue Jul 15 00:00:00 UTC 2014
Metabolism and mis-metabolism of the neuropathological signature protein TDP-43.
Journal of cell science
Huang CC,Bose JK,Majumder P,Lee KH,Huang JT,Huang JK,Shen CK
Tue Jul 15 00:00:00 UTC 2014
Accumulation of C-terminal fragments of transactive response DNA-binding protein 43 leads to synaptic loss and cognitive deficits in human TDP-43 transgenic mice.
Neurobiology of aging
Medina DX,Orr ME,Oddo S
Wed Jan 01 00:00:00 UTC 2014
Accumulation of C-terminal fragments of transactive response DNA-binding protein 43 leads to synaptic loss and cognitive deficits in human TDP-43 transgenic mice.
Neurobiology of aging
Medina DX,Orr ME,Oddo S
Wed Jan 01 00:00:00 UTC 2014
Accumulation of C-terminal fragments of transactive response DNA-binding protein 43 leads to synaptic loss and cognitive deficits in human TDP-43 transgenic mice.
Neurobiology of aging
Medina DX,Orr ME,Oddo S
Wed Jan 01 00:00:00 UTC 2014
Accumulation of C-terminal fragments of transactive response DNA-binding protein 43 leads to synaptic loss and cognitive deficits in human TDP-43 transgenic mice.
Neurobiology of aging
Medina DX,Orr ME,Oddo S
Wed Jan 01 00:00:00 UTC 2014
Hippocampal sclerosis dementia with the C9ORF72 hexanucleotide repeat expansion.
Neurobiology of aging
Pletnikova O,Sloane KL,Renton AE,Traynor BJ,Crain BJ,Reid T,Zu T,Ranum LP,Troncoso JC,Rabins PV,Onyike CU
Wed Oct 01 00:00:00 UTC 2014
Hippocampal sclerosis dementia with the C9ORF72 hexanucleotide repeat expansion.
Neurobiology of aging
Pletnikova O,Sloane KL,Renton AE,Traynor BJ,Crain BJ,Reid T,Zu T,Ranum LP,Troncoso JC,Rabins PV,Onyike CU
Wed Oct 01 00:00:00 UTC 2014
Parkin-mediated reduction of nuclear and soluble TDP-43 reverses behavioral decline in symptomatic mice.
Human molecular genetics
Wenqiang C,Lonskaya I,Hebron ML,Ibrahim Z,Olszewski RT,Neale JH,Moussa CE
Mon Sep 15 00:00:00 UTC 2014
Parkin-mediated reduction of nuclear and soluble TDP-43 reverses behavioral decline in symptomatic mice.
Human molecular genetics
Wenqiang C,Lonskaya I,Hebron ML,Ibrahim Z,Olszewski RT,Neale JH,Moussa CE
Mon Sep 15 00:00:00 UTC 2014
Parkin-mediated reduction of nuclear and soluble TDP-43 reverses behavioral decline in symptomatic mice.
Human molecular genetics
Wenqiang C,Lonskaya I,Hebron ML,Ibrahim Z,Olszewski RT,Neale JH,Moussa CE
Mon Sep 15 00:00:00 UTC 2014
Parkin-mediated reduction of nuclear and soluble TDP-43 reverses behavioral decline in symptomatic mice.
Human molecular genetics
Wenqiang C,Lonskaya I,Hebron ML,Ibrahim Z,Olszewski RT,Neale JH,Moussa CE
Mon Sep 15 00:00:00 UTC 2014
TDP-43 suppresses CGG repeat-induced neurotoxicity through interactions with HnRNP A2/B1.
Human molecular genetics
He F,Krans A,Freibaum BD,Taylor JP,Todd PK
Wed Oct 01 00:00:00 UTC 2014
TDP-43 suppresses CGG repeat-induced neurotoxicity through interactions with HnRNP A2/B1.
Human molecular genetics
He F,Krans A,Freibaum BD,Taylor JP,Todd PK
Wed Oct 01 00:00:00 UTC 2014
TDP-43 suppresses CGG repeat-induced neurotoxicity through interactions with HnRNP A2/B1.
Human molecular genetics
He F,Krans A,Freibaum BD,Taylor JP,Todd PK
Wed Oct 01 00:00:00 UTC 2014
TDP-43 suppresses CGG repeat-induced neurotoxicity through interactions with HnRNP A2/B1.
Human molecular genetics
He F,Krans A,Freibaum BD,Taylor JP,Todd PK
Wed Oct 01 00:00:00 UTC 2014
CGG repeats in RNA modulate expression of TDP-43 in mouse and fly models of fragile X tremor ataxia syndrome.
Human molecular genetics
Galloway JN,Shaw C,Yu P,Parghi D,Poidevin M,Jin P,Nelson DL
Sat Nov 15 00:00:00 UTC 2014
CGG repeats in RNA modulate expression of TDP-43 in mouse and fly models of fragile X tremor ataxia syndrome.
Human molecular genetics
Galloway JN,Shaw C,Yu P,Parghi D,Poidevin M,Jin P,Nelson DL
Sat Nov 15 00:00:00 UTC 2014
TDP-43 Phosphorylation by casein kinase Iε promotes oligomerization and enhances toxicity in vivo.
Human molecular genetics
Choksi DK,Roy B,Chatterjee S,Yusuff T,Bakhoum MF,Sengupta U,Ambegaokar S,Kayed R,Jackson GR
Sat Feb 15 00:00:00 UTC 2014
TDP-43 Phosphorylation by casein kinase Iε promotes oligomerization and enhances toxicity in vivo.
Human molecular genetics
Choksi DK,Roy B,Chatterjee S,Yusuff T,Bakhoum MF,Sengupta U,Ambegaokar S,Kayed R,Jackson GR
Sat Feb 15 00:00:00 UTC 2014
TDP-43 Phosphorylation by casein kinase Iε promotes oligomerization and enhances toxicity in vivo.
Human molecular genetics
Choksi DK,Roy B,Chatterjee S,Yusuff T,Bakhoum MF,Sengupta U,Ambegaokar S,Kayed R,Jackson GR
Sat Feb 15 00:00:00 UTC 2014
TDP-43 Phosphorylation by casein kinase Iε promotes oligomerization and enhances toxicity in vivo.
Human molecular genetics
Choksi DK,Roy B,Chatterjee S,Yusuff T,Bakhoum MF,Sengupta U,Ambegaokar S,Kayed R,Jackson GR
Sat Feb 15 00:00:00 UTC 2014
Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones.
Human molecular genetics
Udan-Johns M,Bengoechea R,Bell S,Shao J,Diamond MI,True HL,Weihl CC,Baloh RH
Wed Jan 01 00:00:00 UTC 2014
Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones.
Human molecular genetics
Udan-Johns M,Bengoechea R,Bell S,Shao J,Diamond MI,True HL,Weihl CC,Baloh RH
Wed Jan 01 00:00:00 UTC 2014
An ALS-mutant TDP-43 neurotoxic peptide adopts an anti-parallel β-structure and induces TDP-43 redistribution.
Human molecular genetics
Zhu L,Xu M,Yang M,Yang Y,Li Y,Deng J,Ruan L,Liu J,Du S,Liu X,Feng W,Fushimi K,Bigio EH,Mesulam M,Wang C,Wu JY
Sat Dec 20 00:00:00 UTC 2014
An ALS-mutant TDP-43 neurotoxic peptide adopts an anti-parallel β-structure and induces TDP-43 redistribution.
Human molecular genetics
Zhu L,Xu M,Yang M,Yang Y,Li Y,Deng J,Ruan L,Liu J,Du S,Liu X,Feng W,Fushimi K,Bigio EH,Mesulam M,Wang C,Wu JY
Sat Dec 20 00:00:00 UTC 2014
An ALS-mutant TDP-43 neurotoxic peptide adopts an anti-parallel β-structure and induces TDP-43 redistribution.
Human molecular genetics
Zhu L,Xu M,Yang M,Yang Y,Li Y,Deng J,Ruan L,Liu J,Du S,Liu X,Feng W,Fushimi K,Bigio EH,Mesulam M,Wang C,Wu JY
Sat Dec 20 00:00:00 UTC 2014
An ALS-mutant TDP-43 neurotoxic peptide adopts an anti-parallel β-structure and induces TDP-43 redistribution.
Human molecular genetics
Zhu L,Xu M,Yang M,Yang Y,Li Y,Deng J,Ruan L,Liu J,Du S,Liu X,Feng W,Fushimi K,Bigio EH,Mesulam M,Wang C,Wu JY
Sat Dec 20 00:00:00 UTC 2014
Abnormal distribution of heterogeneous nuclear ribonucleoproteins in sporadic inclusion body myositis.
Neuromuscular disorders : NMD
Pinkus JL,Amato AA,Taylor JP,Greenberg SA
Tue Jul 01 00:00:00 UTC 2014
Abnormal distribution of heterogeneous nuclear ribonucleoproteins in sporadic inclusion body myositis.
Neuromuscular disorders : NMD
Pinkus JL,Amato AA,Taylor JP,Greenberg SA
Tue Jul 01 00:00:00 UTC 2014
Atypical Alzheimer's disease in an elderly United States resident with amyotrophic lateral sclerosis and pathological tau in spinal motor neurons.
Amyotrophic lateral sclerosis & frontotemporal degeneration
McCluskey LF,Geser F,Elman LB,Van Deerlin VM,Robinson JL,Lee VM,Trojanowski JQ
Mon Sep 01 00:00:00 UTC 2014
Atypical Alzheimer's disease in an elderly United States resident with amyotrophic lateral sclerosis and pathological tau in spinal motor neurons.
Amyotrophic lateral sclerosis & frontotemporal degeneration
McCluskey LF,Geser F,Elman LB,Van Deerlin VM,Robinson JL,Lee VM,Trojanowski JQ
Mon Sep 01 00:00:00 UTC 2014
RNA metabolism in ALS: when normal processes become pathological.
Amyotrophic lateral sclerosis & frontotemporal degeneration
Droppelmann CA,Campos-Melo D,Ishtiaq M,Volkening K,Strong MJ
Mon Sep 01 00:00:00 UTC 2014
A novel GRN mutation (GRN c.708+6_+9delTGAG) in frontotemporal lobar degeneration with TDP-43-positive inclusions: clinicopathologic report of 6 cases.
Journal of neuropathology and experimental neurology
Bit-Ivan EN,Suh E,Shim HS,Weintraub S,Hyman BT,Arnold SE,McCarty-Wood E,Van Deerlin VM,Schneider JA,Trojanowski JQ,Frosch MP,Baker MC,Rademakers R,Mesulam M,Bigio EH
Thu May 01 00:00:00 UTC 2014
A novel GRN mutation (GRN c.708+6_+9delTGAG) in frontotemporal lobar degeneration with TDP-43-positive inclusions: clinicopathologic report of 6 cases.
Journal of neuropathology and experimental neurology
Bit-Ivan EN,Suh E,Shim HS,Weintraub S,Hyman BT,Arnold SE,McCarty-Wood E,Van Deerlin VM,Schneider JA,Trojanowski JQ,Frosch MP,Baker MC,Rademakers R,Mesulam M,Bigio EH
Thu May 01 00:00:00 UTC 2014
Differential motor neuron involvement in progressive muscular atrophy: a comparative study with amyotrophic lateral sclerosis.
BMJ open
Riku Y,Atsuta N,Yoshida M,Tatsumi S,Iwasaki Y,Mimuro M,Watanabe H,Ito M,Senda J,Nakamura R,Koike H,Sobue G
Wed May 14 00:00:00 UTC 2014
Differential motor neuron involvement in progressive muscular atrophy: a comparative study with amyotrophic lateral sclerosis.
BMJ open
Riku Y,Atsuta N,Yoshida M,Tatsumi S,Iwasaki Y,Mimuro M,Watanabe H,Ito M,Senda J,Nakamura R,Koike H,Sobue G
Wed May 14 00:00:00 UTC 2014
A retrospective cohort study identifying the principal pathological features useful in the diagnosis of inclusion body myositis.
BMJ open
Brady S,Squier W,Sewry C,Hanna M,Hilton-Jones D,Holton JL
Mon Apr 28 00:00:00 UTC 2014
A retrospective cohort study identifying the principal pathological features useful in the diagnosis of inclusion body myositis.
BMJ open
Brady S,Squier W,Sewry C,Hanna M,Hilton-Jones D,Holton JL
Mon Apr 28 00:00:00 UTC 2014
A novel approach for integrative studies on neurodegenerative diseases in human brains.
Journal of neuroscience methods
Theofilas P,Polichiso L,Wang X,Lima LC,Alho ATL,Leite REP,Suemoto CK,Pasqualucci CA,Jacob-Filho W,Heinsen H,Grinberg LT
Tue Apr 15 00:00:00 UTC 2014
A novel approach for integrative studies on neurodegenerative diseases in human brains.
Journal of neuroscience methods
Theofilas P,Polichiso L,Wang X,Lima LC,Alho ATL,Leite REP,Suemoto CK,Pasqualucci CA,Jacob-Filho W,Heinsen H,Grinberg LT
Tue Apr 15 00:00:00 UTC 2014
Titinopathy in a Canadian family sharing the British founder haplotype.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Pfeffer G,Joseph JT,Innes AM,Frizzell JB,Wilson IJ,Brownell AK,Chinnery PF
Wed Jan 01 00:00:00 UTC 2014
Titinopathy in a Canadian family sharing the British founder haplotype.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Pfeffer G,Joseph JT,Innes AM,Frizzell JB,Wilson IJ,Brownell AK,Chinnery PF
Wed Jan 01 00:00:00 UTC 2014
Differential diagnosis of amyotrophic lateral sclerosis from Guillain-Barré syndrome by quantitative determination of TDP-43 in cerebrospinal fluid.
The International journal of neuroscience
Hosokawa M,Arai T,Yamashita M,Tsuji H,Nonaka T,Masuda-Suzukake M,Tamaoka A,Hasegawa M,Akiyama H
Thu May 01 00:00:00 UTC 2014
Differential diagnosis of amyotrophic lateral sclerosis from Guillain-Barré syndrome by quantitative determination of TDP-43 in cerebrospinal fluid.
The International journal of neuroscience
Hosokawa M,Arai T,Yamashita M,Tsuji H,Nonaka T,Masuda-Suzukake M,Tamaoka A,Hasegawa M,Akiyama H
Thu May 01 00:00:00 UTC 2014
Corticobasal degeneration initially developing motor versus non-motor symptoms: a comparative clinicopathological study.
Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society
Ikeda C,Yokota O,Nagao S,Ishizu H,Morisada Y,Terada S,Nakashima Y,Akiyama H,Uchitomi Y
Mon Sep 01 00:00:00 UTC 2014
Corticobasal degeneration initially developing motor versus non-motor symptoms: a comparative clinicopathological study.
Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society
Ikeda C,Yokota O,Nagao S,Ishizu H,Morisada Y,Terada S,Nakashima Y,Akiyama H,Uchitomi Y
Mon Sep 01 00:00:00 UTC 2014
Autopsy case of concurrent Huntington's disease and neurofibromatosis type 1.
Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society
Kawakami I,Katsuse O,Aoki N,Togo T,Suzuki K,Isojima D,Kondo D,Iseki E,Kosaka K,Akiyama H,Hirayasu Y
Sat Mar 01 00:00:00 UTC 2014
Autopsy case of concurrent Huntington's disease and neurofibromatosis type 1.
Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society
Kawakami I,Katsuse O,Aoki N,Togo T,Suzuki K,Isojima D,Kondo D,Iseki E,Kosaka K,Akiyama H,Hirayasu Y
Sat Mar 01 00:00:00 UTC 2014
Accumulation of the sigma-1 receptor is common to neuronal nuclear inclusions in various neurodegenerative diseases.
Neuropathology : official journal of the Japanese Society of Neuropathology
Miki Y,Mori F,Kon T,Tanji K,Toyoshima Y,Yoshida M,Sasaki H,Kakita A,Takahashi H,Wakabayashi K
Tue Apr 01 00:00:00 UTC 2014
Accumulation of the sigma-1 receptor is common to neuronal nuclear inclusions in various neurodegenerative diseases.
Neuropathology : official journal of the Japanese Society of Neuropathology
Miki Y,Mori F,Kon T,Tanji K,Toyoshima Y,Yoshida M,Sasaki H,Kakita A,Takahashi H,Wakabayashi K
Tue Apr 01 00:00:00 UTC 2014
Clinicopathologic features of autosomal recessive amyotrophic lateral sclerosis associated with optineurin mutation.
Neuropathology : official journal of the Japanese Society of Neuropathology
Kamada M,Izumi Y,Ayaki T,Nakamura M,Kagawa S,Kudo E,Sako W,Maruyama H,Nishida Y,Kawakami H,Ito H,Kaji R
Sat Feb 01 00:00:00 UTC 2014
Clinicopathologic features of autosomal recessive amyotrophic lateral sclerosis associated with optineurin mutation.
Neuropathology : official journal of the Japanese Society of Neuropathology
Kamada M,Izumi Y,Ayaki T,Nakamura M,Kagawa S,Kudo E,Sako W,Maruyama H,Nishida Y,Kawakami H,Ito H,Kaji R
Sat Feb 01 00:00:00 UTC 2014
Ubiquitin-negative, eosinophilic neuronal cytoplasmic inclusions associated with stress granules and autophagy: an immunohistochemical investigation of two cases.
Neuropathology : official journal of the Japanese Society of Neuropathology
Mori F,Watanabe Y,Miki Y,Tanji K,Odagiri S,Eto K,Wakabayashi K
Tue Apr 01 00:00:00 UTC 2014
Ubiquitin-negative, eosinophilic neuronal cytoplasmic inclusions associated with stress granules and autophagy: an immunohistochemical investigation of two cases.
Neuropathology : official journal of the Japanese Society of Neuropathology
Mori F,Watanabe Y,Miki Y,Tanji K,Odagiri S,Eto K,Wakabayashi K
Tue Apr 01 00:00:00 UTC 2014
Cytoplasmic TDP-43 accumulation in cells of the adrenal medulla in individuals with or without amyotrophic lateral sclerosis.
Neuropathology : official journal of the Japanese Society of Neuropathology
Okamoto K,Amari M,Fujita Y,Makioka K,Fukuda T,Suzuki K,Takatama M
Mon Dec 01 00:00:00 UTC 2014
Cytoplasmic TDP-43 accumulation in cells of the adrenal medulla in individuals with or without amyotrophic lateral sclerosis.
Neuropathology : official journal of the Japanese Society of Neuropathology
Okamoto K,Amari M,Fujita Y,Makioka K,Fukuda T,Suzuki K,Takatama M
Mon Dec 01 00:00:00 UTC 2014
Frontotemporal lobar degeneration with writing disturbance mainly consisting of omission of kana letters.
Neurocase
Shimizu T,Mochizuki Y,Bandoh M,Taguchi T,Mishima K,Takeda K,Nojima K,Mizutani T,Matsubara S
Sun Jun 01 00:00:00 UTC 2014
Brain distribution of dipeptide repeat proteins in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72.
Acta neuropathologica communications
Davidson YS,Barker H,Robinson AC,Thompson JC,Harris J,Troakes C,Smith B,Al-Saraj S,Shaw C,Rollinson S,Masuda-Suzukake M,Hasegawa M,Pickering-Brown S,Snowden JS,Mann DM
Fri Jun 20 00:00:00 UTC 2014
Brain distribution of dipeptide repeat proteins in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72.
Acta neuropathologica communications
Davidson YS,Barker H,Robinson AC,Thompson JC,Harris J,Troakes C,Smith B,Al-Saraj S,Shaw C,Rollinson S,Masuda-Suzukake M,Hasegawa M,Pickering-Brown S,Snowden JS,Mann DM
Fri Jun 20 00:00:00 UTC 2014
The RNA-binding protein TDP-43 selectively disrupts microRNA-1/206 incorporation into the RNA-induced silencing complex.
The Journal of biological chemistry
King IN,Yartseva V,Salas D,Kumar A,Heidersbach A,Ando DM,Stallings NR,Elliott JL,Srivastava D,Ivey KN
Fri May 16 00:00:00 UTC 2014
The RNA-binding protein TDP-43 selectively disrupts microRNA-1/206 incorporation into the RNA-induced silencing complex.
The Journal of biological chemistry
King IN,Yartseva V,Salas D,Kumar A,Heidersbach A,Ando DM,Stallings NR,Elliott JL,Srivastava D,Ivey KN
Fri May 16 00:00:00 UTC 2014
The RNA-binding protein TDP-43 selectively disrupts microRNA-1/206 incorporation into the RNA-induced silencing complex.
The Journal of biological chemistry
King IN,Yartseva V,Salas D,Kumar A,Heidersbach A,Ando DM,Stallings NR,Elliott JL,Srivastava D,Ivey KN
Fri May 16 00:00:00 UTC 2014
The RNA-binding protein TDP-43 selectively disrupts microRNA-1/206 incorporation into the RNA-induced silencing complex.
The Journal of biological chemistry
King IN,Yartseva V,Salas D,Kumar A,Heidersbach A,Ando DM,Stallings NR,Elliott JL,Srivastava D,Ivey KN
Fri May 16 00:00:00 UTC 2014
Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice.
Acta neuropathologica communications
Tanaka Y,Chambers JK,Matsuwaki T,Yamanouchi K,Nishihara M
Tue Jul 15 00:00:00 UTC 2014
Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice.
Acta neuropathologica communications
Tanaka Y,Chambers JK,Matsuwaki T,Yamanouchi K,Nishihara M
Tue Jul 15 00:00:00 UTC 2014
Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice.
Acta neuropathologica communications
Tanaka Y,Chambers JK,Matsuwaki T,Yamanouchi K,Nishihara M
Tue Jul 15 00:00:00 UTC 2014
NF-Y inactivation causes atypical neurodegeneration characterized by ubiquitin and p62 accumulation and endoplasmic reticulum disorganization.
Nature communications
Yamanaka T,Tosaki A,Kurosawa M,Matsumoto G,Koike M,Uchiyama Y,Maity SN,Shimogori T,Hattori N,Nukina N
Tue Feb 25 00:00:00 UTC 2014
NF-Y inactivation causes atypical neurodegeneration characterized by ubiquitin and p62 accumulation and endoplasmic reticulum disorganization.
Nature communications
Yamanaka T,Tosaki A,Kurosawa M,Matsumoto G,Koike M,Uchiyama Y,Maity SN,Shimogori T,Hattori N,Nukina N
Tue Feb 25 00:00:00 UTC 2014
H63D HFE genotype accelerates disease progression in animal models of amyotrophic lateral sclerosis.
Biochimica et biophysica acta
Nandar W,Neely EB,Simmons Z,Connor JR
Mon Dec 01 00:00:00 UTC 2014
H63D HFE genotype accelerates disease progression in animal models of amyotrophic lateral sclerosis.
Biochimica et biophysica acta
Nandar W,Neely EB,Simmons Z,Connor JR
Mon Dec 01 00:00:00 UTC 2014
TDP-43 pathology in the basal forebrain and hypothalamus of patients with amyotrophic lateral sclerosis.
Acta neuropathologica communications
Cykowski MD,Takei H,Schulz PE,Appel SH,Powell SZ
Wed Dec 24 00:00:00 UTC 2014
TDP-43 pathology in the basal forebrain and hypothalamus of patients with amyotrophic lateral sclerosis.
Acta neuropathologica communications
Cykowski MD,Takei H,Schulz PE,Appel SH,Powell SZ
Wed Dec 24 00:00:00 UTC 2014
FTLD-ALS of TDP-43 type and SCA2 in a family with a full ataxin-2 polyglutamine expansion.
Acta neuropathologica
Bäumer D,East SZ,Tseu B,Zeman A,Hilton D,Talbot K,Ansorge O
Wed Oct 01 00:00:00 UTC 2014
Mutant TDP-43 deregulates AMPK activation by PP2A in ALS models.
PloS one
Perera ND,Sheean RK,Scott JW,Kemp BE,Horne MK,Turner BJ
Mon Feb 09 00:00:00 UTC 2015
Mutant TDP-43 deregulates AMPK activation by PP2A in ALS models.
PloS one
Perera ND,Sheean RK,Scott JW,Kemp BE,Horne MK,Turner BJ
Mon Feb 09 00:00:00 UTC 2015
Neuropathological features of genetically confirmed DYT1 dystonia: investigating disease-specific inclusions.
Acta neuropathologica communications
Paudel R,Kiely A,Li A,Lashley T,Bandopadhyay R,Hardy J,Jinnah HA,Bhatia K,Houlden H,Holton JL
Tue Nov 18 00:00:00 UTC 2014
Neuropathological features of genetically confirmed DYT1 dystonia: investigating disease-specific inclusions.
Acta neuropathologica communications
Paudel R,Kiely A,Li A,Lashley T,Bandopadhyay R,Hardy J,Jinnah HA,Bhatia K,Houlden H,Holton JL
Tue Nov 18 00:00:00 UTC 2014
Divergent phenotypes in mutant TDP-43 transgenic mice highlight potential confounds in TDP-43 transgenic modeling.
PloS one
D'Alton S,Altshuler M,Cannon A,Dickson DW,Petrucelli L,Lewis J
Tue Nov 04 00:00:00 UTC 2014
Divergent phenotypes in mutant TDP-43 transgenic mice highlight potential confounds in TDP-43 transgenic modeling.
PloS one
D'Alton S,Altshuler M,Cannon A,Dickson DW,Petrucelli L,Lewis J
Tue Nov 04 00:00:00 UTC 2014
TDP-43 regulates β-adducin (Add2) transcript stability.
RNA biology
Costessi L,Porro F,Iaconcig A,Muro AF
Tue Sep 22 00:00:00 UTC 2015
Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells.
PloS one
Nishimura AL,Shum C,Scotter EL,Abdelgany A,Sardone V,Wright J,Lee YB,Chen HJ,Bilican B,Carrasco M,Maniatis T,Chandran S,Rogelj B,Gallo JM,Shaw CE
Mon Dec 22 00:00:00 UTC 2014
Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells.
PloS one
Nishimura AL,Shum C,Scotter EL,Abdelgany A,Sardone V,Wright J,Lee YB,Chen HJ,Bilican B,Carrasco M,Maniatis T,Chandran S,Rogelj B,Gallo JM,Shaw CE
Mon Dec 22 00:00:00 UTC 2014
Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells.
PloS one
Nishimura AL,Shum C,Scotter EL,Abdelgany A,Sardone V,Wright J,Lee YB,Chen HJ,Bilican B,Carrasco M,Maniatis T,Chandran S,Rogelj B,Gallo JM,Shaw CE
Mon Dec 22 00:00:00 UTC 2014
Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells.
PloS one
Nishimura AL,Shum C,Scotter EL,Abdelgany A,Sardone V,Wright J,Lee YB,Chen HJ,Bilican B,Carrasco M,Maniatis T,Chandran S,Rogelj B,Gallo JM,Shaw CE
Mon Dec 22 00:00:00 UTC 2014
Mitochondrial dysfunction and decrease in body weight of transgenic knock-in mouse model for TDP-43: the question of glucose?
The Journal of biological chemistry
Jawaid A,Gapp K,Schulz PE
Fri Jun 27 00:00:00 UTC 2014
Mitochondrial dysfunction and decrease in body weight of transgenic knock-in mouse model for TDP-43: the question of glucose?
The Journal of biological chemistry
Jawaid A,Gapp K,Schulz PE
Fri Jun 27 00:00:00 UTC 2014
Mitochondrial dysfunction and decrease in body weight of transgenic knock-in mouse model for TDP-43: the question of glucose?
The Journal of biological chemistry
Jawaid A,Gapp K,Schulz PE
Fri Jun 27 00:00:00 UTC 2014
Mitochondrial dysfunction and decrease in body weight of transgenic knock-in mouse model for TDP-43: the question of glucose?
The Journal of biological chemistry
Jawaid A,Gapp K,Schulz PE
Fri Jun 27 00:00:00 UTC 2014
Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant.
Acta neuropathologica communications
Ayaki T,Ito H,Fukushima H,Inoue T,Kondo T,Ikemoto A,Asano T,Shodai A,Fujita T,Fukui S,Morino H,Nakano S,Kusaka H,Yamashita H,Ihara M,Matsumoto R,Kawamata J,Urushitani M,Kawakami H,Takahashi R
Wed Dec 10 00:00:00 UTC 2014
Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant.
Acta neuropathologica communications
Ayaki T,Ito H,Fukushima H,Inoue T,Kondo T,Ikemoto A,Asano T,Shodai A,Fujita T,Fukui S,Morino H,Nakano S,Kusaka H,Yamashita H,Ihara M,Matsumoto R,Kawamata J,Urushitani M,Kawakami H,Takahashi R
Wed Dec 10 00:00:00 UTC 2014
Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant.
Acta neuropathologica communications
Ayaki T,Ito H,Fukushima H,Inoue T,Kondo T,Ikemoto A,Asano T,Shodai A,Fujita T,Fukui S,Morino H,Nakano S,Kusaka H,Yamashita H,Ihara M,Matsumoto R,Kawamata J,Urushitani M,Kawakami H,Takahashi R
Wed Dec 10 00:00:00 UTC 2014
Mutant TDP-43 deregulates AMPK activation by PP2A in ALS models.
PloS one
Perera ND,Sheean RK,Scott JW,Kemp BE,Horne MK,Turner BJ
Mon Jun 01 00:00:00 UTC 2015
Mutant TDP-43 deregulates AMPK activation by PP2A in ALS models.
PloS one
Perera ND,Sheean RK,Scott JW,Kemp BE,Horne MK,Turner BJ
Mon Jun 01 00:00:00 UTC 2015
Mutant TDP-43 deregulates AMPK activation by PP2A in ALS models.
PloS one
Perera ND,Sheean RK,Scott JW,Kemp BE,Horne MK,Turner BJ
Mon Jun 01 00:00:00 UTC 2015
Casein kinase II induced polymerization of soluble TDP-43 into filaments is inhibited by heat shock proteins.
PloS one
Carlomagno Y,Zhang Y,Davis M,Lin WL,Cook C,Dunmore J,Tay W,Menkosky K,Cao X,Petrucelli L,Deture M
Mon Feb 09 00:00:00 UTC 2015
Casein kinase II induced polymerization of soluble TDP-43 into filaments is inhibited by heat shock proteins.
PloS one
Carlomagno Y,Zhang Y,Davis M,Lin WL,Cook C,Dunmore J,Tay W,Menkosky K,Cao X,Petrucelli L,Deture M
Mon Feb 09 00:00:00 UTC 2015
Gene targeting of mouse Tardbp negatively affects Masp2 expression.
PloS one
Dib S,Xiao S,Miletic D,Robertson J
Mon Jun 01 00:00:00 UTC 2015
Gene targeting of mouse Tardbp negatively affects Masp2 expression.
PloS one
Dib S,Xiao S,Miletic D,Robertson J
Mon Jun 01 00:00:00 UTC 2015
Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.
The Journal of biological chemistry
Stribl C,Samara A,Trümbach D,Peis R,Neumann M,Fuchs H,Gailus-Durner V,Hrabě de Angelis M,Rathkolb B,Wolf E,Beckers J,Horsch M,Neff F,Kremmer E,Koob S,Reichert AS,Hans W,Rozman J,Klingenspor M,Aichler M,Walch AK,Becker L,Klopstock T,Glasl L,Hölter SM,Wurst W,Floss T
Fri Apr 11 00:00:00 UTC 2014
Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.
The Journal of biological chemistry
Stribl C,Samara A,Trümbach D,Peis R,Neumann M,Fuchs H,Gailus-Durner V,Hrabě de Angelis M,Rathkolb B,Wolf E,Beckers J,Horsch M,Neff F,Kremmer E,Koob S,Reichert AS,Hans W,Rozman J,Klingenspor M,Aichler M,Walch AK,Becker L,Klopstock T,Glasl L,Hölter SM,Wurst W,Floss T
Fri Apr 11 00:00:00 UTC 2014
Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.
The Journal of biological chemistry
Stribl C,Samara A,Trümbach D,Peis R,Neumann M,Fuchs H,Gailus-Durner V,Hrabě de Angelis M,Rathkolb B,Wolf E,Beckers J,Horsch M,Neff F,Kremmer E,Koob S,Reichert AS,Hans W,Rozman J,Klingenspor M,Aichler M,Walch AK,Becker L,Klopstock T,Glasl L,Hölter SM,Wurst W,Floss T
Fri Apr 11 00:00:00 UTC 2014
Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.
The Journal of biological chemistry
Stribl C,Samara A,Trümbach D,Peis R,Neumann M,Fuchs H,Gailus-Durner V,Hrabě de Angelis M,Rathkolb B,Wolf E,Beckers J,Horsch M,Neff F,Kremmer E,Koob S,Reichert AS,Hans W,Rozman J,Klingenspor M,Aichler M,Walch AK,Becker L,Klopstock T,Glasl L,Hölter SM,Wurst W,Floss T
Fri Apr 11 00:00:00 UTC 2014
Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.
The Journal of biological chemistry
Stribl C,Samara A,Trümbach D,Peis R,Neumann M,Fuchs H,Gailus-Durner V,Hrabě de Angelis M,Rathkolb B,Wolf E,Beckers J,Horsch M,Neff F,Kremmer E,Koob S,Reichert AS,Hans W,Rozman J,Klingenspor M,Aichler M,Walch AK,Becker L,Klopstock T,Glasl L,Hölter SM,Wurst W,Floss T
Fri Apr 11 00:00:00 UTC 2014
Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.
The Journal of biological chemistry
Stribl C,Samara A,Trümbach D,Peis R,Neumann M,Fuchs H,Gailus-Durner V,Hrabě de Angelis M,Rathkolb B,Wolf E,Beckers J,Horsch M,Neff F,Kremmer E,Koob S,Reichert AS,Hans W,Rozman J,Klingenspor M,Aichler M,Walch AK,Becker L,Klopstock T,Glasl L,Hölter SM,Wurst W,Floss T
Fri Apr 11 00:00:00 UTC 2014
The co-occurrence of Alzheimer's disease and Huntington's disease: a neuropathological study of 15 elderly Huntington's disease subjects.
Journal of Huntington's disease
Davis MY,Keene CD,Jayadev S,Bird T
Tue Sep 23 00:00:00 UTC 2014
The co-occurrence of Alzheimer's disease and Huntington's disease: a neuropathological study of 15 elderly Huntington's disease subjects.
Journal of Huntington's disease
Davis MY,Keene CD,Jayadev S,Bird T
Tue Sep 23 00:00:00 UTC 2014
Phenotype of transgenic mice carrying a very low copy number of the mutant human G93A superoxide dismutase-1 gene associated with amyotrophic lateral sclerosis.
PloS one
Deitch JS,Alexander GM,Bensinger A,Yang S,Jiang JT,Heiman-Patterson TD
Mon Oct 19 00:00:00 UTC 2015
Phenotype of transgenic mice carrying a very low copy number of the mutant human G93A superoxide dismutase-1 gene associated with amyotrophic lateral sclerosis.
PloS one
Deitch JS,Alexander GM,Bensinger A,Yang S,Jiang JT,Heiman-Patterson TD
Mon Oct 19 00:00:00 UTC 2015
UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination.
The Journal of biological chemistry
Hans F,Fiesel FC,Strong JC,Jäckel S,Rasse TM,Geisler S,Springer W,Schulz JB,Voigt A,Kahle PJ
Fri Jul 04 00:00:00 UTC 2014
UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination.
The Journal of biological chemistry
Hans F,Fiesel FC,Strong JC,Jäckel S,Rasse TM,Geisler S,Springer W,Schulz JB,Voigt A,Kahle PJ
Fri Jul 04 00:00:00 UTC 2014
UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination.
The Journal of biological chemistry
Hans F,Fiesel FC,Strong JC,Jäckel S,Rasse TM,Geisler S,Springer W,Schulz JB,Voigt A,Kahle PJ
Fri Jul 04 00:00:00 UTC 2014
UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination.
The Journal of biological chemistry
Hans F,Fiesel FC,Strong JC,Jäckel S,Rasse TM,Geisler S,Springer W,Schulz JB,Voigt A,Kahle PJ
Fri Jul 04 00:00:00 UTC 2014
Aggregation properties of the small nuclear ribonucleoprotein U1-70K in Alzheimer disease.
The Journal of biological chemistry
Diner I,Hales CM,Bishof I,Rabenold L,Duong DM,Yi H,Laur O,Gearing M,Troncoso J,Thambisetty M,Lah JJ,Levey AI,Seyfried NT
Fri Dec 19 00:00:00 UTC 2014
Aggregation properties of the small nuclear ribonucleoprotein U1-70K in Alzheimer disease.
The Journal of biological chemistry
Diner I,Hales CM,Bishof I,Rabenold L,Duong DM,Yi H,Laur O,Gearing M,Troncoso J,Thambisetty M,Lah JJ,Levey AI,Seyfried NT
Fri Dec 19 00:00:00 UTC 2014
Th1 response and systemic treg deficiency in inclusion body myositis.
PloS one
Allenbach Y,Chaara W,Rosenzwajg M,Six A,Prevel N,Mingozzi F,Wanschitz J,Musset L,Charuel JL,Eymard B,Salomon B,Duyckaerts C,Maisonobe T,Dubourg O,Herson S,Klatzmann D,Benveniste O
Mon Feb 09 00:00:00 UTC 2015
Th1 response and systemic treg deficiency in inclusion body myositis.
PloS one
Allenbach Y,Chaara W,Rosenzwajg M,Six A,Prevel N,Mingozzi F,Wanschitz J,Musset L,Charuel JL,Eymard B,Salomon B,Duyckaerts C,Maisonobe T,Dubourg O,Herson S,Klatzmann D,Benveniste O
Mon Feb 09 00:00:00 UTC 2015
RNA-processing protein TDP-43 regulates FOXO-dependent protein quality control in stress response.
PLoS genetics
Zhang T,Baldie G,Periz G,Wang J
Wed Oct 01 00:00:00 UTC 2014
RNA-processing protein TDP-43 regulates FOXO-dependent protein quality control in stress response.
PLoS genetics
Zhang T,Baldie G,Periz G,Wang J
Wed Oct 01 00:00:00 UTC 2014
RNA-processing protein TDP-43 regulates FOXO-dependent protein quality control in stress response.
PLoS genetics
Zhang T,Baldie G,Periz G,Wang J
Wed Oct 01 00:00:00 UTC 2014
RNA-processing protein TDP-43 regulates FOXO-dependent protein quality control in stress response.
PLoS genetics
Zhang T,Baldie G,Periz G,Wang J
Wed Oct 01 00:00:00 UTC 2014
RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth.
Oncotarget
Wilson-Edell KA,Kehasse A,Scott GK,Yau C,Rothschild DE,Schilling B,Gabriel BS,Yevtushenko MA,Hanson IM,Held JM,Gibson BW,Benz CC
Tue Jul 15 00:00:00 UTC 2014
RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth.
Oncotarget
Wilson-Edell KA,Kehasse A,Scott GK,Yau C,Rothschild DE,Schilling B,Gabriel BS,Yevtushenko MA,Hanson IM,Held JM,Gibson BW,Benz CC
Tue Jul 15 00:00:00 UTC 2014
Dendritic retraction, but not atrophy, is consistent in amyotrophic lateral sclerosis-comparison between Onuf's neurons and other sacral motor neurons.
Acta neuropathologica communications
Takeda T,Uchihara T,Nakayama Y,Nakamura A,Sasaki S,Kakei S,Uchiyama S,Duyckaerts C,Yoshida M
Mon Jan 27 00:00:00 UTC 2014
Dendritic retraction, but not atrophy, is consistent in amyotrophic lateral sclerosis-comparison between Onuf's neurons and other sacral motor neurons.
Acta neuropathologica communications
Takeda T,Uchihara T,Nakayama Y,Nakamura A,Sasaki S,Kakei S,Uchiyama S,Duyckaerts C,Yoshida M
Mon Jan 27 00:00:00 UTC 2014
Reduced cellular Ca(2+) availability enhances TDP-43 cleavage by apoptotic caspases.
Biochimica et biophysica acta
De Marco G,Lomartire A,Mandili G,Lupino E,Buccinnà B,Ramondetti C,Moglia C,Novelli F,Piccinini M,Mostert M,Rinaudo MT,Chiò A,Calvo A
Tue Apr 01 00:00:00 UTC 2014
Reduced cellular Ca(2+) availability enhances TDP-43 cleavage by apoptotic caspases.
Biochimica et biophysica acta
De Marco G,Lomartire A,Mandili G,Lupino E,Buccinnà B,Ramondetti C,Moglia C,Novelli F,Piccinini M,Mostert M,Rinaudo MT,Chiò A,Calvo A
Tue Apr 01 00:00:00 UTC 2014
Myopathy-causing mutations in an HSP40 chaperone disrupt processing of specific client conformers.
The Journal of biological chemistry
Stein KC,Bengoechea R,Harms MB,Weihl CC,True HL
Fri Jul 25 00:00:00 UTC 2014
Myopathy-causing mutations in an HSP40 chaperone disrupt processing of specific client conformers.
The Journal of biological chemistry
Stein KC,Bengoechea R,Harms MB,Weihl CC,True HL
Fri Jul 25 00:00:00 UTC 2014
A high-content screen identifies novel compounds that inhibit stress-induced TDP-43 cellular aggregation and associated cytotoxicity.
Journal of biomolecular screening
Boyd JD,Lee P,Feiler MS,Zauur N,Liu M,Concannon J,Ebata A,Wolozin B,Glicksman MA
Wed Jan 01 00:00:00 UTC 2014
A high-content screen identifies novel compounds that inhibit stress-induced TDP-43 cellular aggregation and associated cytotoxicity.
Journal of biomolecular screening
Boyd JD,Lee P,Feiler MS,Zauur N,Liu M,Concannon J,Ebata A,Wolozin B,Glicksman MA
Wed Jan 01 00:00:00 UTC 2014
Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS.
Nature
Kim HJ,Kim NC,Wang YD,Scarborough EA,Moore J,Diaz Z,MacLea KS,Freibaum B,Li S,Molliex A,Kanagaraj AP,Carter R,Boylan KB,Wojtas AM,Rademakers R,Pinkus JL,Greenberg SA,Trojanowski JQ,Traynor BJ,Smith BN,Topp S,Gkazi AS,Miller J,Shaw CE,Kottlors M,Kirschner J,Pestronk A,Li YR,Ford AF,Gitler AD,Benatar M,King OD,Kimonis VE,Ross ED,Weihl CC,Shorter J,Taylor JP
Thu Mar 28 00:00:00 UTC 2013
Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS.
Nature
Kim HJ,Kim NC,Wang YD,Scarborough EA,Moore J,Diaz Z,MacLea KS,Freibaum B,Li S,Molliex A,Kanagaraj AP,Carter R,Boylan KB,Wojtas AM,Rademakers R,Pinkus JL,Greenberg SA,Trojanowski JQ,Traynor BJ,Smith BN,Topp S,Gkazi AS,Miller J,Shaw CE,Kottlors M,Kirschner J,Pestronk A,Li YR,Ford AF,Gitler AD,Benatar M,King OD,Kimonis VE,Ross ED,Weihl CC,Shorter J,Taylor JP
Thu Mar 28 00:00:00 UTC 2013
Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS.
Nature
Kim HJ,Kim NC,Wang YD,Scarborough EA,Moore J,Diaz Z,MacLea KS,Freibaum B,Li S,Molliex A,Kanagaraj AP,Carter R,Boylan KB,Wojtas AM,Rademakers R,Pinkus JL,Greenberg SA,Trojanowski JQ,Traynor BJ,Smith BN,Topp S,Gkazi AS,Miller J,Shaw CE,Kottlors M,Kirschner J,Pestronk A,Li YR,Ford AF,Gitler AD,Benatar M,King OD,Kimonis VE,Ross ED,Weihl CC,Shorter J,Taylor JP
Thu Mar 28 00:00:00 UTC 2013
Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS.
Nature
Kim HJ,Kim NC,Wang YD,Scarborough EA,Moore J,Diaz Z,MacLea KS,Freibaum B,Li S,Molliex A,Kanagaraj AP,Carter R,Boylan KB,Wojtas AM,Rademakers R,Pinkus JL,Greenberg SA,Trojanowski JQ,Traynor BJ,Smith BN,Topp S,Gkazi AS,Miller J,Shaw CE,Kottlors M,Kirschner J,Pestronk A,Li YR,Ford AF,Gitler AD,Benatar M,King OD,Kimonis VE,Ross ED,Weihl CC,Shorter J,Taylor JP
Thu Mar 28 00:00:00 UTC 2013
Eukaryotic stress granules are cleared by autophagy and Cdc48/VCP function.
Cell
Buchan JR,Kolaitis RM,Taylor JP,Parker R
Thu Jun 20 00:00:00 UTC 2013
Eukaryotic stress granules are cleared by autophagy and Cdc48/VCP function.
Cell
Buchan JR,Kolaitis RM,Taylor JP,Parker R
Thu Jun 20 00:00:00 UTC 2013
The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.
Science (New York, N.Y.)
Mori K,Weng SM,Arzberger T,May S,Rentzsch K,Kremmer E,Schmid B,Kretzschmar HA,Cruts M,Van Broeckhoven C,Haass C,Edbauer D
Fri Mar 15 00:00:00 UTC 2013
The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.
Science (New York, N.Y.)
Mori K,Weng SM,Arzberger T,May S,Rentzsch K,Kremmer E,Schmid B,Kretzschmar HA,Cruts M,Van Broeckhoven C,Haass C,Edbauer D
Fri Mar 15 00:00:00 UTC 2013
Progranulin mutations as risk factors for Alzheimer disease.
JAMA neurology
Perry DC,Lehmann M,Yokoyama JS,Karydas A,Lee JJ,Coppola G,Grinberg LT,Geschwind D,Seeley WW,Miller BL,Rosen H,Rabinovici G
Sat Jun 01 00:00:00 UTC 2013
Progranulin mutations as risk factors for Alzheimer disease.
JAMA neurology
Perry DC,Lehmann M,Yokoyama JS,Karydas A,Lee JJ,Coppola G,Grinberg LT,Geschwind D,Seeley WW,Miller BL,Rosen H,Rabinovici G
Sat Jun 01 00:00:00 UTC 2013
Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion.
Science translational medicine
Sareen D,O'Rourke JG,Meera P,Muhammad AK,Grant S,Simpkinson M,Bell S,Carmona S,Ornelas L,Sahabian A,Gendron T,Petrucelli L,Baughn M,Ravits J,Harms MB,Rigo F,Bennett CF,Otis TS,Svendsen CN,Baloh RH
Wed Oct 23 00:00:00 UTC 2013
Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion.
Science translational medicine
Sareen D,O'Rourke JG,Meera P,Muhammad AK,Grant S,Simpkinson M,Bell S,Carmona S,Ornelas L,Sahabian A,Gendron T,Petrucelli L,Baughn M,Ravits J,Harms MB,Rigo F,Bennett CF,Otis TS,Svendsen CN,Baloh RH
Wed Oct 23 00:00:00 UTC 2013
Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells".
Science translational medicine
Bilican B,Serio A,Barmada SJ,Nishimura AL,Sullivan GJ,Carrasco M,Phatnani HP,Puddifoot CA,Story D,Fletcher J,Park IH,Friedman BA,Daley GQ,Wyllie DJ,Hardingham GE,Wilmut I,Finkbeiner S,Maniatis T,Shaw CE,Chandran S
Wed Jun 05 00:00:00 UTC 2013
Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells".
Science translational medicine
Bilican B,Serio A,Barmada SJ,Nishimura AL,Sullivan GJ,Carrasco M,Phatnani HP,Puddifoot CA,Story D,Fletcher J,Park IH,Friedman BA,Daley GQ,Wyllie DJ,Hardingham GE,Wilmut I,Finkbeiner S,Maniatis T,Shaw CE,Chandran S
Wed Jun 05 00:00:00 UTC 2013
Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells".
Science translational medicine
Bilican B,Serio A,Barmada SJ,Nishimura AL,Sullivan GJ,Carrasco M,Phatnani HP,Puddifoot CA,Story D,Fletcher J,Park IH,Friedman BA,Daley GQ,Wyllie DJ,Hardingham GE,Wilmut I,Finkbeiner S,Maniatis T,Shaw CE,Chandran S
Wed Jun 05 00:00:00 UTC 2013
Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells".
Science translational medicine
Bilican B,Serio A,Barmada SJ,Nishimura AL,Sullivan GJ,Carrasco M,Phatnani HP,Puddifoot CA,Story D,Fletcher J,Park IH,Friedman BA,Daley GQ,Wyllie DJ,Hardingham GE,Wilmut I,Finkbeiner S,Maniatis T,Shaw CE,Chandran S
Wed Jun 05 00:00:00 UTC 2013
RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention.
Neuron
Donnelly CJ,Zhang PW,Pham JT,Haeusler AR,Mistry NA,Vidensky S,Daley EL,Poth EM,Hoover B,Fines DM,Maragakis N,Tienari PJ,Petrucelli L,Traynor BJ,Wang J,Rigo F,Bennett CF,Blackshaw S,Sattler R,Rothstein JD
Wed Oct 16 00:00:00 UTC 2013
RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention.
Neuron
Donnelly CJ,Zhang PW,Pham JT,Haeusler AR,Mistry NA,Vidensky S,Daley EL,Poth EM,Hoover B,Fines DM,Maragakis N,Tienari PJ,Petrucelli L,Traynor BJ,Wang J,Rigo F,Bennett CF,Blackshaw S,Sattler R,Rothstein JD
Wed Oct 16 00:00:00 UTC 2013
Sporadic ALS with compound heterozygous mutations in the SQSTM1 gene.
Acta neuropathologica
Shimizu H,Toyoshima Y,Shiga A,Yokoseki A,Arakawa K,Sekine Y,Shimohata T,Ikeuchi T,Nishizawa M,Kakita A,Onodera O,Takahashi H
Sun Sep 01 00:00:00 UTC 2013
Sporadic ALS with compound heterozygous mutations in the SQSTM1 gene.
Acta neuropathologica
Shimizu H,Toyoshima Y,Shiga A,Yokoseki A,Arakawa K,Sekine Y,Shimohata T,Ikeuchi T,Nishizawa M,Kakita A,Onodera O,Takahashi H
Sun Sep 01 00:00:00 UTC 2013
Sporadic ALS with compound heterozygous mutations in the SQSTM1 gene.
Acta neuropathologica
Shimizu H,Toyoshima Y,Shiga A,Yokoseki A,Arakawa K,Sekine Y,Shimohata T,Ikeuchi T,Nishizawa M,Kakita A,Onodera O,Takahashi H
Sun Sep 01 00:00:00 UTC 2013
Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations.
Acta neuropathologica
Mackenzie IR,Arzberger T,Kremmer E,Troost D,Lorenzl S,Mori K,Weng SM,Haass C,Kretzschmar HA,Edbauer D,Neumann M
Sun Dec 01 00:00:00 UTC 2013
Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations.
Acta neuropathologica
Mackenzie IR,Arzberger T,Kremmer E,Troost D,Lorenzl S,Mori K,Weng SM,Haass C,Kretzschmar HA,Edbauer D,Neumann M
Sun Dec 01 00:00:00 UTC 2013
Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons.
Acta neuropathologica
Almeida S,Gascon E,Tran H,Chou HJ,Gendron TF,Degroot S,Tapper AR,Sellier C,Charlet-Berguerand N,Karydas A,Seeley WW,Boxer AL,Petrucelli L,Miller BL,Gao FB
Sun Sep 01 00:00:00 UTC 2013
Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons.
Acta neuropathologica
Almeida S,Gascon E,Tran H,Chou HJ,Gendron TF,Degroot S,Tapper AR,Sellier C,Charlet-Berguerand N,Karydas A,Seeley WW,Boxer AL,Petrucelli L,Miller BL,Gao FB
Sun Sep 01 00:00:00 UTC 2013
Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy.
Acta neuropathologica
Clippinger AK,D'Alton S,Lin WL,Gendron TF,Howard J,Borchelt DR,Cannon A,Carlomagno Y,Chakrabarty P,Cook C,Golde TE,Levites Y,Ranum L,Schultheis PJ,Xu G,Petrucelli L,Sahara N,Dickson DW,Giasson B,Lewis J
Mon Jul 01 00:00:00 UTC 2013
Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy.
Acta neuropathologica
Clippinger AK,D'Alton S,Lin WL,Gendron TF,Howard J,Borchelt DR,Cannon A,Carlomagno Y,Chakrabarty P,Cook C,Golde TE,Levites Y,Ranum L,Schultheis PJ,Xu G,Petrucelli L,Sahara N,Dickson DW,Giasson B,Lewis J
Mon Jul 01 00:00:00 UTC 2013
Loss of TDP-43 causes age-dependent progressive motor neuron degeneration.
Brain : a journal of neurology
Iguchi Y,Katsuno M,Niwa J,Takagi S,Ishigaki S,Ikenaka K,Kawai K,Watanabe H,Yamanaka K,Takahashi R,Misawa H,Sasaki S,Tanaka F,Sobue G
Wed May 01 00:00:00 UTC 2013
Loss of TDP-43 causes age-dependent progressive motor neuron degeneration.
Brain : a journal of neurology
Iguchi Y,Katsuno M,Niwa J,Takagi S,Ishigaki S,Ikenaka K,Kawai K,Watanabe H,Yamanaka K,Takahashi R,Misawa H,Sasaki S,Tanaka F,Sobue G
Wed May 01 00:00:00 UTC 2013
Loss of TDP-43 causes age-dependent progressive motor neuron degeneration.
Brain : a journal of neurology
Iguchi Y,Katsuno M,Niwa J,Takagi S,Ishigaki S,Ikenaka K,Kawai K,Watanabe H,Yamanaka K,Takahashi R,Misawa H,Sasaki S,Tanaka F,Sobue G
Wed May 01 00:00:00 UTC 2013
Loss of TDP-43 causes age-dependent progressive motor neuron degeneration.
Brain : a journal of neurology
Iguchi Y,Katsuno M,Niwa J,Takagi S,Ishigaki S,Ikenaka K,Kawai K,Watanabe H,Yamanaka K,Takahashi R,Misawa H,Sasaki S,Tanaka F,Sobue G
Wed May 01 00:00:00 UTC 2013
Degeneration of serotonergic neurons in amyotrophic lateral sclerosis: a link to spasticity.
Brain : a journal of neurology
Dentel C,Palamiuc L,Henriques A,Lannes B,Spreux-Varoquaux O,Gutknecht L,René F,Echaniz-Laguna A,Gonzalez de Aguilar JL,Lesch KP,Meininger V,Loeffler JP,Dupuis L
Fri Feb 01 00:00:00 UTC 2013
Degeneration of serotonergic neurons in amyotrophic lateral sclerosis: a link to spasticity.
Brain : a journal of neurology
Dentel C,Palamiuc L,Henriques A,Lannes B,Spreux-Varoquaux O,Gutknecht L,René F,Echaniz-Laguna A,Gonzalez de Aguilar JL,Lesch KP,Meininger V,Loeffler JP,Dupuis L
Fri Feb 01 00:00:00 UTC 2013
Oligodendrocyte dysfunction in the pathogenesis of amyotrophic lateral sclerosis.
Brain : a journal of neurology
Philips T,Bento-Abreu A,Nonneman A,Haeck W,Staats K,Geelen V,Hersmus N,Küsters B,Van Den Bosch L,Van Damme P,Richardson WD,Robberecht W
Fri Feb 01 00:00:00 UTC 2013
Oligodendrocyte dysfunction in the pathogenesis of amyotrophic lateral sclerosis.
Brain : a journal of neurology
Philips T,Bento-Abreu A,Nonneman A,Haeck W,Staats K,Geelen V,Hersmus N,Küsters B,Van Den Bosch L,Van Damme P,Richardson WD,Robberecht W
Fri Feb 01 00:00:00 UTC 2013
Cell number changes in Alzheimer's disease relate to dementia, not to plaques and tangles.
Brain : a journal of neurology
Andrade-Moraes CH,Oliveira-Pinto AV,Castro-Fonseca E,da Silva CG,Guimarães DM,Szczupak D,Parente-Bruno DR,Carvalho LR,Polichiso L,Gomes BV,Oliveira LM,Rodriguez RD,Leite RE,Ferretti-Rebustini RE,Jacob-Filho W,Pasqualucci CA,Grinberg LT,Lent R
Sun Dec 01 00:00:00 UTC 2013
Cell number changes in Alzheimer's disease relate to dementia, not to plaques and tangles.
Brain : a journal of neurology
Andrade-Moraes CH,Oliveira-Pinto AV,Castro-Fonseca E,da Silva CG,Guimarães DM,Szczupak D,Parente-Bruno DR,Carvalho LR,Polichiso L,Gomes BV,Oliveira LM,Rodriguez RD,Leite RE,Ferretti-Rebustini RE,Jacob-Filho W,Pasqualucci CA,Grinberg LT,Lent R
Sun Dec 01 00:00:00 UTC 2013
Corticospinal tract degeneration associated with TDP-43 type C pathology and semantic dementia.
Brain : a journal of neurology
Josephs KA,Whitwell JL,Murray ME,Parisi JE,Graff-Radford NR,Knopman DS,Boeve BF,Senjem ML,Rademakers R,Jack CR,Petersen RC,Dickson DW
Fri Feb 01 00:00:00 UTC 2013
Corticospinal tract degeneration associated with TDP-43 type C pathology and semantic dementia.
Brain : a journal of neurology
Josephs KA,Whitwell JL,Murray ME,Parisi JE,Graff-Radford NR,Knopman DS,Boeve BF,Senjem ML,Rademakers R,Jack CR,Petersen RC,Dickson DW
Fri Feb 01 00:00:00 UTC 2013
Rescue of amyotrophic lateral sclerosis phenotype in a mouse model by intravenous AAV9-ADAR2 delivery to motor neurons.
EMBO molecular medicine
Yamashita T,Chai HL,Teramoto S,Tsuji S,Shimazaki K,Muramatsu S,Kwak S
Fri Nov 01 00:00:00 UTC 2013
Rescue of amyotrophic lateral sclerosis phenotype in a mouse model by intravenous AAV9-ADAR2 delivery to motor neurons.
EMBO molecular medicine
Yamashita T,Chai HL,Teramoto S,Tsuji S,Shimazaki K,Muramatsu S,Kwak S
Fri Nov 01 00:00:00 UTC 2013
Spliceosome integrity is defective in the motor neuron diseases ALS and SMA.
EMBO molecular medicine
Tsuiji H,Iguchi Y,Furuya A,Kataoka A,Hatsuta H,Atsuta N,Tanaka F,Hashizume Y,Akatsu H,Murayama S,Sobue G,Yamanaka K
Fri Feb 01 00:00:00 UTC 2013
Spliceosome integrity is defective in the motor neuron diseases ALS and SMA.
EMBO molecular medicine
Tsuiji H,Iguchi Y,Furuya A,Kataoka A,Hatsuta H,Atsuta N,Tanaka F,Hashizume Y,Akatsu H,Murayama S,Sobue G,Yamanaka K
Fri Feb 01 00:00:00 UTC 2013
Spliceosome integrity is defective in the motor neuron diseases ALS and SMA.
EMBO molecular medicine
Tsuiji H,Iguchi Y,Furuya A,Kataoka A,Hatsuta H,Atsuta N,Tanaka F,Hashizume Y,Akatsu H,Murayama S,Sobue G,Yamanaka K
Fri Feb 01 00:00:00 UTC 2013
Spliceosome integrity is defective in the motor neuron diseases ALS and SMA.
EMBO molecular medicine
Tsuiji H,Iguchi Y,Furuya A,Kataoka A,Hatsuta H,Atsuta N,Tanaka F,Hashizume Y,Akatsu H,Murayama S,Sobue G,Yamanaka K
Fri Feb 01 00:00:00 UTC 2013
Japanese amyotrophic lateral sclerosis patients with GGGGCC hexanucleotide repeat expansion in C9ORF72.
Journal of neurology, neurosurgery, and psychiatry
Konno T,Shiga A,Tsujino A,Sugai A,Kato T,Kanai K,Yokoseki A,Eguchi H,Kuwabara S,Nishizawa M,Takahashi H,Onodera O
Mon Apr 01 00:00:00 UTC 2013
Japanese amyotrophic lateral sclerosis patients with GGGGCC hexanucleotide repeat expansion in C9ORF72.
Journal of neurology, neurosurgery, and psychiatry
Konno T,Shiga A,Tsujino A,Sugai A,Kato T,Kanai K,Yokoseki A,Eguchi H,Kuwabara S,Nishizawa M,Takahashi H,Onodera O
Mon Apr 01 00:00:00 UTC 2013
African ancestry protects against Alzheimer's disease-related neuropathology.
Molecular psychiatry
Schlesinger D,Grinberg LT,Alba JG,Naslavsky MS,Licinio L,Farfel JM,Suemoto CK,de Lucena Ferretti RE,Leite RE,de Andrade MP,dos Santos AC,Brentani H,Pasqualucci CA,Nitrini R,Jacob-Filho W,Zatz M
Tue Jan 01 00:00:00 UTC 2013
African ancestry protects against Alzheimer's disease-related neuropathology.
Molecular psychiatry
Schlesinger D,Grinberg LT,Alba JG,Naslavsky MS,Licinio L,Farfel JM,Suemoto CK,de Lucena Ferretti RE,Leite RE,de Andrade MP,dos Santos AC,Brentani H,Pasqualucci CA,Nitrini R,Jacob-Filho W,Zatz M
Tue Jan 01 00:00:00 UTC 2013
Selective forelimb impairment in rats expressing a pathological TDP-43 25 kDa C-terminal fragment to mimic amyotrophic lateral sclerosis.
Molecular therapy : the journal of the American Society of Gene Therapy
Dayton RD,Gitcho MA,Orchard EA,Wilson JD,Wang DB,Cain CD,Johnson JA,Zhang YJ,Petrucelli L,Mathis JM,Klein RL
Mon Jul 01 00:00:00 UTC 2013
Selective forelimb impairment in rats expressing a pathological TDP-43 25 kDa C-terminal fragment to mimic amyotrophic lateral sclerosis.
Molecular therapy : the journal of the American Society of Gene Therapy
Dayton RD,Gitcho MA,Orchard EA,Wilson JD,Wang DB,Cain CD,Johnson JA,Zhang YJ,Petrucelli L,Mathis JM,Klein RL
Mon Jul 01 00:00:00 UTC 2013
Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration.
Proceedings of the National Academy of Sciences of the United States of America
Lagier-Tourenne C,Baughn M,Rigo F,Sun S,Liu P,Li HR,Jiang J,Watt AT,Chun S,Katz M,Qiu J,Sun Y,Ling SC,Zhu Q,Polymenidou M,Drenner K,Artates JW,McAlonis-Downes M,Markmiller S,Hutt KR,Pizzo DP,Cady J,Harms MB,Baloh RH,Vandenberg SR,Yeo GW,Fu XD,Bennett CF,Cleveland DW,Ravits J
Tue Nov 19 00:00:00 UTC 2013
Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration.
Proceedings of the National Academy of Sciences of the United States of America
Lagier-Tourenne C,Baughn M,Rigo F,Sun S,Liu P,Li HR,Jiang J,Watt AT,Chun S,Katz M,Qiu J,Sun Y,Ling SC,Zhu Q,Polymenidou M,Drenner K,Artates JW,McAlonis-Downes M,Markmiller S,Hutt KR,Pizzo DP,Cady J,Harms MB,Baloh RH,Vandenberg SR,Yeo GW,Fu XD,Bennett CF,Cleveland DW,Ravits J
Tue Nov 19 00:00:00 UTC 2013
Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration.
Proceedings of the National Academy of Sciences of the United States of America
Xu Z,Poidevin M,Li X,Li Y,Shu L,Nelson DL,Li H,Hales CM,Gearing M,Wingo TS,Jin P
Tue May 07 00:00:00 UTC 2013
Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration.
Proceedings of the National Academy of Sciences of the United States of America
Xu Z,Poidevin M,Li X,Li Y,Shu L,Nelson DL,Li H,Hales CM,Gearing M,Wingo TS,Jin P
Tue May 07 00:00:00 UTC 2013
Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration.
Proceedings of the National Academy of Sciences of the United States of America
Xu Z,Poidevin M,Li X,Li Y,Shu L,Nelson DL,Li H,Hales CM,Gearing M,Wingo TS,Jin P
Tue May 07 00:00:00 UTC 2013
Functional genomic screen of human stem cell differentiation reveals pathways involved in neurodevelopment and neurodegeneration.
Proceedings of the National Academy of Sciences of the United States of America
Zhang Y,Schulz VP,Reed BD,Wang Z,Pan X,Mariani J,Euskirchen G,Snyder MP,Vaccarino FM,Ivanova N,Weissman SM,Szekely AM
Tue Jul 23 00:00:00 UTC 2013
Functional genomic screen of human stem cell differentiation reveals pathways involved in neurodevelopment and neurodegeneration.
Proceedings of the National Academy of Sciences of the United States of America
Zhang Y,Schulz VP,Reed BD,Wang Z,Pan X,Mariani J,Euskirchen G,Snyder MP,Vaccarino FM,Ivanova N,Weissman SM,Szekely AM
Tue Jul 23 00:00:00 UTC 2013
Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy.
Proceedings of the National Academy of Sciences of the United States of America
Serio A,Bilican B,Barmada SJ,Ando DM,Zhao C,Siller R,Burr K,Haghi G,Story D,Nishimura AL,Carrasco MA,Phatnani HP,Shum C,Wilmut I,Maniatis T,Shaw CE,Finkbeiner S,Chandran S
Tue Mar 19 00:00:00 UTC 2013
Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy.
Proceedings of the National Academy of Sciences of the United States of America
Serio A,Bilican B,Barmada SJ,Ando DM,Zhao C,Siller R,Burr K,Haghi G,Story D,Nishimura AL,Carrasco MA,Phatnani HP,Shum C,Wilmut I,Maniatis T,Shaw CE,Finkbeiner S,Chandran S
Tue Mar 19 00:00:00 UTC 2013
Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy.
Proceedings of the National Academy of Sciences of the United States of America
Serio A,Bilican B,Barmada SJ,Ando DM,Zhao C,Siller R,Burr K,Haghi G,Story D,Nishimura AL,Carrasco MA,Phatnani HP,Shum C,Wilmut I,Maniatis T,Shaw CE,Finkbeiner S,Chandran S
Tue Mar 19 00:00:00 UTC 2013
Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy.
Proceedings of the National Academy of Sciences of the United States of America
Serio A,Bilican B,Barmada SJ,Ando DM,Zhao C,Siller R,Burr K,Haghi G,Story D,Nishimura AL,Carrasco MA,Phatnani HP,Shum C,Wilmut I,Maniatis T,Shaw CE,Finkbeiner S,Chandran S
Tue Mar 19 00:00:00 UTC 2013
New NBIA subtype: genetic, clinical, pathologic, and radiographic features of MPAN.
Neurology
Hogarth P,Gregory A,Kruer MC,Sanford L,Wagoner W,Natowicz MR,Egel RT,Subramony SH,Goldman JG,Berry-Kravis E,Foulds NC,Hammans SR,Desguerre I,Rodriguez D,Wilson C,Diedrich A,Green S,Tran H,Reese L,Woltjer RL,Hayflick SJ
Tue Jan 15 00:00:00 UTC 2013
New NBIA subtype: genetic, clinical, pathologic, and radiographic features of MPAN.
Neurology
Hogarth P,Gregory A,Kruer MC,Sanford L,Wagoner W,Natowicz MR,Egel RT,Subramony SH,Goldman JG,Berry-Kravis E,Foulds NC,Hammans SR,Desguerre I,Rodriguez D,Wilson C,Diedrich A,Green S,Tran H,Reese L,Woltjer RL,Hayflick SJ
Tue Jan 15 00:00:00 UTC 2013
G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome.
Annals of neurology
Lesage S,Anheim M,Letournel F,Bousset L,Honoré A,Rozas N,Pieri L,Madiona K,Dürr A,Melki R,Verny C,Brice A
Mon Apr 01 00:00:00 UTC 2013
G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome.
Annals of neurology
Lesage S,Anheim M,Letournel F,Bousset L,Honoré A,Rozas N,Pieri L,Madiona K,Dürr A,Melki R,Verny C,Brice A
Mon Apr 01 00:00:00 UTC 2013
Familial dementia with frontotemporal features associated with M146V presenilin-1 mutation.
Brain pathology (Zurich, Switzerland)
Riudavets MA,Bartoloni L,Troncoso JC,Pletnikova O,St George-Hyslop P,Schultz M,Sevlever G,Allegri RF
Sun Sep 01 00:00:00 UTC 2013
Familial dementia with frontotemporal features associated with M146V presenilin-1 mutation.
Brain pathology (Zurich, Switzerland)
Riudavets MA,Bartoloni L,Troncoso JC,Pletnikova O,St George-Hyslop P,Schultz M,Sevlever G,Allegri RF
Sun Sep 01 00:00:00 UTC 2013
Pharmacological reduction of ER stress protects against TDP-43 neuronal toxicity in vivo.
Neurobiology of disease
Vaccaro A,Patten SA,Aggad D,Julien C,Maios C,Kabashi E,Drapeau P,Parker JA
Mon Jul 01 00:00:00 UTC 2013
Pharmacological reduction of ER stress protects against TDP-43 neuronal toxicity in vivo.
Neurobiology of disease
Vaccaro A,Patten SA,Aggad D,Julien C,Maios C,Kabashi E,Drapeau P,Parker JA
Mon Jul 01 00:00:00 UTC 2013
Glucocorticoids exacerbate cognitive deficits in TDP-25 transgenic mice via a glutathione-mediated mechanism: implications for aging, stress and TDP-43 proteinopathies.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Caccamo A,Medina DX,Oddo S
Wed Jan 16 00:00:00 UTC 2013
Glucocorticoids exacerbate cognitive deficits in TDP-25 transgenic mice via a glutathione-mediated mechanism: implications for aging, stress and TDP-43 proteinopathies.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Caccamo A,Medina DX,Oddo S
Wed Jan 16 00:00:00 UTC 2013
Amyotrophic lateral sclerosis: an update on recent genetic insights.
Journal of neurology
Iguchi Y,Katsuno M,Ikenaka K,Ishigaki S,Sobue G
Fri Nov 01 00:00:00 UTC 2013
Amyotrophic lateral sclerosis: an update on recent genetic insights.
Journal of neurology
Iguchi Y,Katsuno M,Ikenaka K,Ishigaki S,Sobue G
Fri Nov 01 00:00:00 UTC 2013
Nuclear carrier and RNA-binding proteins in frontotemporal lobar degeneration associated with fused in sarcoma (FUS) pathological changes.
Neuropathology and applied neurobiology
Davidson YS,Robinson AC,Hu Q,Mishra M,Baborie A,Jaros E,Perry RH,Cairns NJ,Richardson A,Gerhard A,Neary D,Snowden JS,Bigio EH,Mann DM
Fri Feb 01 00:00:00 UTC 2013
Nuclear carrier and RNA-binding proteins in frontotemporal lobar degeneration associated with fused in sarcoma (FUS) pathological changes.
Neuropathology and applied neurobiology
Davidson YS,Robinson AC,Hu Q,Mishra M,Baborie A,Jaros E,Perry RH,Cairns NJ,Richardson A,Gerhard A,Neary D,Snowden JS,Bigio EH,Mann DM
Fri Feb 01 00:00:00 UTC 2013
Regionally different immunoreactivity for Smurf2 and pSmad2/3 in TDP-43-positive inclusions of amyotrophic lateral sclerosis.
Neuropathology and applied neurobiology
Nakamura M,Kaneko S,Wate R,Asayama S,Nakamura Y,Fujita K,Ito H,Kusaka H
Fri Feb 01 00:00:00 UTC 2013
Regionally different immunoreactivity for Smurf2 and pSmad2/3 in TDP-43-positive inclusions of amyotrophic lateral sclerosis.
Neuropathology and applied neurobiology
Nakamura M,Kaneko S,Wate R,Asayama S,Nakamura Y,Fujita K,Ito H,Kusaka H
Fri Feb 01 00:00:00 UTC 2013
Laminar distribution of the pathological changes in sporadic frontotemporal lobar degeneration with transactive response (TAR) DNA-binding protein of 43 kDa (TDP-43) proteinopathy: a quantitative study using polynomial curve fitting.
Neuropathology and applied neurobiology
Armstrong RA,Hamilton RL,Mackenzie IR,Hedreen J,Cairns NJ
Sat Jun 01 00:00:00 UTC 2013
Laminar distribution of the pathological changes in sporadic frontotemporal lobar degeneration with transactive response (TAR) DNA-binding protein of 43 kDa (TDP-43) proteinopathy: a quantitative study using polynomial curve fitting.
Neuropathology and applied neurobiology
Armstrong RA,Hamilton RL,Mackenzie IR,Hedreen J,Cairns NJ
Sat Jun 01 00:00:00 UTC 2013
Pantothenate kinase-associated neurodegeneration is not a synucleinopathy.
Neuropathology and applied neurobiology
Li A,Paudel R,Johnson R,Courtney R,Lees AJ,Holton JL,Hardy J,Revesz T,Houlden H
Fri Feb 01 00:00:00 UTC 2013
Pantothenate kinase-associated neurodegeneration is not a synucleinopathy.
Neuropathology and applied neurobiology
Li A,Paudel R,Johnson R,Courtney R,Lees AJ,Holton JL,Hardy J,Revesz T,Houlden H
Fri Feb 01 00:00:00 UTC 2013
A clinicopathological and genetic study of sporadic diffuse leukoencephalopathy with spheroids: a report of two cases.
Neuropathology and applied neurobiology
Kimura T,Ishizawa K,Mitsufuji T,Abe T,Nakazato Y,Yoshida K,Sasaki A,Araki N
Sun Dec 01 00:00:00 UTC 2013
A clinicopathological and genetic study of sporadic diffuse leukoencephalopathy with spheroids: a report of two cases.
Neuropathology and applied neurobiology
Kimura T,Ishizawa K,Mitsufuji T,Abe T,Nakazato Y,Yoshida K,Sasaki A,Araki N
Sun Dec 01 00:00:00 UTC 2013
Optineurin is potentially associated with TDP-43 and involved in the pathogenesis of inclusion body myositis.
Neuropathology and applied neurobiology
Yamashita S,Kimura E,Tawara N,Sakaguchi H,Nakama T,Maeda Y,Hirano T,Uchino M,Ando Y
Sat Jun 01 00:00:00 UTC 2013
Optineurin is potentially associated with TDP-43 and involved in the pathogenesis of inclusion body myositis.
Neuropathology and applied neurobiology
Yamashita S,Kimura E,Tawara N,Sakaguchi H,Nakama T,Maeda Y,Hirano T,Uchino M,Ando Y
Sat Jun 01 00:00:00 UTC 2013
Lack of unique neuropathology in amyotrophic lateral sclerosis associated with p.K54E angiogenin (ANG) mutation.
Neuropathology and applied neurobiology
Kirby J,Highley JR,Cox L,Goodall EF,Hewitt C,Hartley JA,Hollinger HC,Fox M,Ince PG,McDermott CJ,Shaw PJ
Thu Aug 01 00:00:00 UTC 2013
Lack of unique neuropathology in amyotrophic lateral sclerosis associated with p.K54E angiogenin (ANG) mutation.
Neuropathology and applied neurobiology
Kirby J,Highley JR,Cox L,Goodall EF,Hewitt C,Hartley JA,Hollinger HC,Fox M,Ince PG,McDermott CJ,Shaw PJ
Thu Aug 01 00:00:00 UTC 2013
β-N-methylamino-l-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): the first step towards an experimental model for sporadic ALS.
Environmental toxicology and pharmacology
de Munck E,Muñoz-Sáez E,Miguel BG,Solas MT,Ojeda I,Martínez A,Gil C,Arahuetes RM
Sun Sep 01 00:00:00 UTC 2013
β-N-methylamino-l-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): the first step towards an experimental model for sporadic ALS.
Environmental toxicology and pharmacology
de Munck E,Muñoz-Sáez E,Miguel BG,Solas MT,Ojeda I,Martínez A,Gil C,Arahuetes RM
Sun Sep 01 00:00:00 UTC 2013
Making the diagnosis of frontotemporal lobar degeneration.
Archives of pathology & laboratory medicine
Bigio EH
Fri Mar 01 00:00:00 UTC 2013
Making the diagnosis of frontotemporal lobar degeneration.
Archives of pathology & laboratory medicine
Bigio EH
Fri Mar 01 00:00:00 UTC 2013
Overexpression of ALS-associated p.M337V human TDP-43 in mice worsens disease features compared to wild-type human TDP-43 mice.
Molecular neurobiology
Janssens J,Wils H,Kleinberger G,Joris G,Cuijt I,Ceuterick-de Groote C,Van Broeckhoven C,Kumar-Singh S
Thu Aug 01 00:00:00 UTC 2013
Overexpression of ALS-associated p.M337V human TDP-43 in mice worsens disease features compared to wild-type human TDP-43 mice.
Molecular neurobiology
Janssens J,Wils H,Kleinberger G,Joris G,Cuijt I,Ceuterick-de Groote C,Van Broeckhoven C,Kumar-Singh S
Thu Aug 01 00:00:00 UTC 2013
Overexpression of ALS-associated p.M337V human TDP-43 in mice worsens disease features compared to wild-type human TDP-43 mice.
Molecular neurobiology
Janssens J,Wils H,Kleinberger G,Joris G,Cuijt I,Ceuterick-de Groote C,Van Broeckhoven C,Kumar-Singh S
Thu Aug 01 00:00:00 UTC 2013
Altered astrocytic expression of TDP-43 does not influence motor neuron survival.
Experimental neurology
Haidet-Phillips AM,Gross SK,Williams T,Tuteja A,Sherman A,Ko M,Jeong YH,Wong PC,Maragakis NJ
Sun Dec 01 00:00:00 UTC 2013
Altered astrocytic expression of TDP-43 does not influence motor neuron survival.
Experimental neurology
Haidet-Phillips AM,Gross SK,Williams T,Tuteja A,Sherman A,Ko M,Jeong YH,Wong PC,Maragakis NJ
Sun Dec 01 00:00:00 UTC 2013
Neuron enriched nuclear proteome isolated from human brain.
Journal of proteome research
Dammer EB,Duong DM,Diner I,Gearing M,Feng Y,Lah JJ,Levey AI,Seyfried NT
Fri Jul 05 00:00:00 UTC 2013
Neuron enriched nuclear proteome isolated from human brain.
Journal of proteome research
Dammer EB,Duong DM,Diner I,Gearing M,Feng Y,Lah JJ,Levey AI,Seyfried NT
Fri Jul 05 00:00:00 UTC 2013
C9ORF72 expansion in a family with bipolar disorder.
Bipolar disorders
Meisler MH,Grant AE,Jones JM,Lenk GM,He F,Todd PK,Kamali M,Albin RL,Lieberman AP,Langenecker SA,McInnis MG
Wed May 01 00:00:00 UTC 2013
C9ORF72 expansion in a family with bipolar disorder.
Bipolar disorders
Meisler MH,Grant AE,Jones JM,Lenk GM,He F,Todd PK,Kamali M,Albin RL,Lieberman AP,Langenecker SA,McInnis MG
Wed May 01 00:00:00 UTC 2013
Mutation analysis and immunopathological studies of PFN1 in familial and sporadic amyotrophic lateral sclerosis.
Neurobiology of aging
Yang S,Fifita JA,Williams KL,Warraich ST,Pamphlett R,Nicholson GA,Blair IP
Sun Sep 01 00:00:00 UTC 2013
Mutation analysis and immunopathological studies of PFN1 in familial and sporadic amyotrophic lateral sclerosis.
Neurobiology of aging
Yang S,Fifita JA,Williams KL,Warraich ST,Pamphlett R,Nicholson GA,Blair IP
Sun Sep 01 00:00:00 UTC 2013
RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy.
Human molecular genetics
Ihara R,Matsukawa K,Nagata Y,Kunugi H,Tsuji S,Chihara T,Kuranaga E,Miura M,Wakabayashi T,Hashimoto T,Iwatsubo T
Fri Nov 15 00:00:00 UTC 2013
RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy.
Human molecular genetics
Ihara R,Matsukawa K,Nagata Y,Kunugi H,Tsuji S,Chihara T,Kuranaga E,Miura M,Wakabayashi T,Hashimoto T,Iwatsubo T
Fri Nov 15 00:00:00 UTC 2013
RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy.
Human molecular genetics
Ihara R,Matsukawa K,Nagata Y,Kunugi H,Tsuji S,Chihara T,Kuranaga E,Miura M,Wakabayashi T,Hashimoto T,Iwatsubo T
Fri Nov 15 00:00:00 UTC 2013
RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy.
Human molecular genetics
Ihara R,Matsukawa K,Nagata Y,Kunugi H,Tsuji S,Chihara T,Kuranaga E,Miura M,Wakabayashi T,Hashimoto T,Iwatsubo T
Fri Nov 15 00:00:00 UTC 2013
Tardbpl splicing rescues motor neuron and axonal development in a mutant tardbp zebrafish.
Human molecular genetics
Hewamadduma CA,Grierson AJ,Ma TP,Pan L,Moens CB,Ingham PW,Ramesh T,Shaw PJ
Sat Jun 15 00:00:00 UTC 2013
Tardbpl splicing rescues motor neuron and axonal development in a mutant tardbp zebrafish.
Human molecular genetics
Hewamadduma CA,Grierson AJ,Ma TP,Pan L,Moens CB,Ingham PW,Ramesh T,Shaw PJ
Sat Jun 15 00:00:00 UTC 2013
The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function.
Human molecular genetics
Brady OA,Zheng Y,Murphy K,Huang M,Hu F
Fri Feb 15 00:00:00 UTC 2013
The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function.
Human molecular genetics
Brady OA,Zheng Y,Murphy K,Huang M,Hu F
Fri Feb 15 00:00:00 UTC 2013
The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function.
Human molecular genetics
Brady OA,Zheng Y,Murphy K,Huang M,Hu F
Fri Feb 15 00:00:00 UTC 2013
The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function.
Human molecular genetics
Brady OA,Zheng Y,Murphy K,Huang M,Hu F
Fri Feb 15 00:00:00 UTC 2013
The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation.
Human molecular genetics
Zhang YJ,Caulfield T,Xu YF,Gendron TF,Hubbard J,Stetler C,Sasaguri H,Whitelaw EC,Cai S,Lee WC,Petrucelli L
Thu Aug 01 00:00:00 UTC 2013
The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation.
Human molecular genetics
Zhang YJ,Caulfield T,Xu YF,Gendron TF,Hubbard J,Stetler C,Sasaguri H,Whitelaw EC,Cai S,Lee WC,Petrucelli L
Thu Aug 01 00:00:00 UTC 2013
Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models.
Human molecular genetics
Tauffenberger A,Chitramuthu BP,Bateman A,Bennett HP,Parker JA
Fri Feb 15 00:00:00 UTC 2013
Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models.
Human molecular genetics
Tauffenberger A,Chitramuthu BP,Bateman A,Bennett HP,Parker JA
Fri Feb 15 00:00:00 UTC 2013
Decreased number of Gemini of coiled bodies and U12 snRNA level in amyotrophic lateral sclerosis.
Human molecular genetics
Ishihara T,Ariizumi Y,Shiga A,Kato T,Tan CF,Sato T,Miki Y,Yokoo M,Fujino T,Koyama A,Yokoseki A,Nishizawa M,Kakita A,Takahashi H,Onodera O
Tue Oct 15 00:00:00 UTC 2013
Decreased number of Gemini of coiled bodies and U12 snRNA level in amyotrophic lateral sclerosis.
Human molecular genetics
Ishihara T,Ariizumi Y,Shiga A,Kato T,Tan CF,Sato T,Miki Y,Yokoo M,Fujino T,Koyama A,Yokoseki A,Nishizawa M,Kakita A,Takahashi H,Onodera O
Tue Oct 15 00:00:00 UTC 2013
Welander distal myopathy caused by an ancient founder mutation in TIA1 associated with perturbed splicing.
Human mutation
Klar J,Sobol M,Melberg A,Mäbert K,Ameur A,Johansson AC,Feuk L,Entesarian M,Orlén H,Casar-Borota O,Dahl N
Mon Apr 01 00:00:00 UTC 2013
Welander distal myopathy caused by an ancient founder mutation in TIA1 associated with perturbed splicing.
Human mutation
Klar J,Sobol M,Melberg A,Mäbert K,Ameur A,Johansson AC,Feuk L,Entesarian M,Orlén H,Casar-Borota O,Dahl N
Mon Apr 01 00:00:00 UTC 2013
A cellular model for sporadic ALS using patient-derived induced pluripotent stem cells.
Molecular and cellular neurosciences
Burkhardt MF,Martinez FJ,Wright S,Ramos C,Volfson D,Mason M,Garnes J,Dang V,Lievers J,Shoukat-Mumtaz U,Martinez R,Gai H,Blake R,Vaisberg E,Grskovic M,Johnson C,Irion S,Bright J,Cooper B,Nguyen L,Griswold-Prenner I,Javaherian A
Sun Sep 01 00:00:00 UTC 2013
A cellular model for sporadic ALS using patient-derived induced pluripotent stem cells.
Molecular and cellular neurosciences
Burkhardt MF,Martinez FJ,Wright S,Ramos C,Volfson D,Mason M,Garnes J,Dang V,Lievers J,Shoukat-Mumtaz U,Martinez R,Gai H,Blake R,Vaisberg E,Grskovic M,Johnson C,Irion S,Bright J,Cooper B,Nguyen L,Griswold-Prenner I,Javaherian A
Sun Sep 01 00:00:00 UTC 2013
Pathological features of FTLD-FUS in a Japanese population: analyses of nine cases.
Journal of the neurological sciences
Kobayashi Z,Kawakami I,Arai T,Yokota O,Tsuchiya K,Kondo H,Shimomura Y,Haga C,Aoki N,Hasegawa M,Hosokawa M,Oshima K,Niizato K,Ishizu H,Terada S,Onaya M,Ikeda M,Oyanagi K,Nakano I,Murayama S,Akiyama H,Mizusawa H
Sun Dec 15 00:00:00 UTC 2013
Pathological features of FTLD-FUS in a Japanese population: analyses of nine cases.
Journal of the neurological sciences
Kobayashi Z,Kawakami I,Arai T,Yokota O,Tsuchiya K,Kondo H,Shimomura Y,Haga C,Aoki N,Hasegawa M,Hosokawa M,Oshima K,Niizato K,Ishizu H,Terada S,Onaya M,Ikeda M,Oyanagi K,Nakano I,Murayama S,Akiyama H,Mizusawa H
Sun Dec 15 00:00:00 UTC 2013
Frontotemporal lobar degeneration: diversity of FTLD lesions.
Revue neurologique
Seilhean D,Bielle F,Plu I,Duyckaerts C
Tue Oct 01 00:00:00 UTC 2013
Clinicopathologic study of Alzheimer's disease: Alzheimer mimics.
Journal of Alzheimer's disease : JAD
Shim YS,Roe CM,Buckles VD,Morris JC
Tue Dec 10 00:00:00 UTC 2013
Expression of myogenic regulatory factors and myo-endothelial remodeling in sporadic inclusion body myositis.
Neuromuscular disorders : NMD
Wanschitz JV,Dubourg O,Lacene E,Fischer MB,Höftberger R,Budka H,Romero NB,Eymard B,Herson S,Butler-Browne GS,Voit T,Benveniste O
Tue Jan 01 00:00:00 UTC 2013
Expression of myogenic regulatory factors and myo-endothelial remodeling in sporadic inclusion body myositis.
Neuromuscular disorders : NMD
Wanschitz JV,Dubourg O,Lacene E,Fischer MB,Höftberger R,Budka H,Romero NB,Eymard B,Herson S,Butler-Browne GS,Voit T,Benveniste O
Tue Jan 01 00:00:00 UTC 2013
DNAJB6 myopathy in an Asian cohort and cytoplasmic/nuclear inclusions.
Neuromuscular disorders : NMD
Sato T,Hayashi YK,Oya Y,Kondo T,Sugie K,Kaneda D,Houzen H,Yabe I,Sasaki H,Noguchi S,Nonaka I,Osawa M,Nishino I
Fri Mar 01 00:00:00 UTC 2013
DNAJB6 myopathy in an Asian cohort and cytoplasmic/nuclear inclusions.
Neuromuscular disorders : NMD
Sato T,Hayashi YK,Oya Y,Kondo T,Sugie K,Kaneda D,Houzen H,Yabe I,Sasaki H,Noguchi S,Nonaka I,Osawa M,Nishino I
Fri Mar 01 00:00:00 UTC 2013
α-Synuclein coaggregation in familial amyotrophic lateral sclerosis with SOD1 gene mutation.
Human pathology
Takei Y,Oguchi K,Koshihara H,Hineno A,Nakamura A,Ohara S
Sat Jun 01 00:00:00 UTC 2013
α-Synuclein coaggregation in familial amyotrophic lateral sclerosis with SOD1 gene mutation.
Human pathology
Takei Y,Oguchi K,Koshihara H,Hineno A,Nakamura A,Ohara S
Sat Jun 01 00:00:00 UTC 2013
Luminescent conjugated oligothiophenes for sensitive fluorescent assignment of protein inclusion bodies.
Chembiochem : a European journal of chemical biology
Klingstedt T,Blechschmidt C,Nogalska A,Prokop S,Häggqvist B,Danielsson O,Engel WK,Askanas V,Heppner FL,Nilsson KP
Mon Mar 18 00:00:00 UTC 2013
Luminescent conjugated oligothiophenes for sensitive fluorescent assignment of protein inclusion bodies.
Chembiochem : a European journal of chemical biology
Klingstedt T,Blechschmidt C,Nogalska A,Prokop S,Häggqvist B,Danielsson O,Engel WK,Askanas V,Heppner FL,Nilsson KP
Mon Mar 18 00:00:00 UTC 2013
Activation of transforming growth factor-β/Smad signaling reduces aggregate formation of mislocalized TAR DNA-binding protein-43.
Neuro-degenerative diseases
Nakamura M,Kaneko S,Ito H,Jiang S,Fujita K,Wate R,Nakano S,Fujisawa J,Kusaka H
Wed Nov 13 00:00:00 UTC 2013
Activation of transforming growth factor-β/Smad signaling reduces aggregate formation of mislocalized TAR DNA-binding protein-43.
Neuro-degenerative diseases
Nakamura M,Kaneko S,Ito H,Jiang S,Fujita K,Wate R,Nakano S,Fujisawa J,Kusaka H
Wed Nov 13 00:00:00 UTC 2013
Activation of transforming growth factor-β/Smad signaling reduces aggregate formation of mislocalized TAR DNA-binding protein-43.
Neuro-degenerative diseases
Nakamura M,Kaneko S,Ito H,Jiang S,Fujita K,Wate R,Nakano S,Fujisawa J,Kusaka H
Wed Nov 13 00:00:00 UTC 2013
Activation of transforming growth factor-β/Smad signaling reduces aggregate formation of mislocalized TAR DNA-binding protein-43.
Neuro-degenerative diseases
Nakamura M,Kaneko S,Ito H,Jiang S,Fujita K,Wate R,Nakano S,Fujisawa J,Kusaka H
Wed Nov 13 00:00:00 UTC 2013
Neuropathology of partial PGC-1α deficiency recapitulates features of mitochondrial encephalopathies but not of neurodegenerative diseases.
Neuro-degenerative diseases
Szalardy L,Zadori D,Plangar I,Vecsei L,Weydt P,Ludolph AC,Klivenyi P,Kovacs GG
Mon Apr 21 00:00:00 UTC 2014
Neuropathology of partial PGC-1α deficiency recapitulates features of mitochondrial encephalopathies but not of neurodegenerative diseases.
Neuro-degenerative diseases
Szalardy L,Zadori D,Plangar I,Vecsei L,Weydt P,Ludolph AC,Klivenyi P,Kovacs GG
Mon Apr 21 00:00:00 UTC 2014
Involvement of endoplasmic reticulum stress in tauopathy.
Biochemical and biophysical research communications
Sakagami Y,Kudo T,Tanimukai H,Kanayama D,Omi T,Horiguchi K,Okochi M,Imaizumi K,Takeda M
Fri Jan 11 00:00:00 UTC 2013
Involvement of endoplasmic reticulum stress in tauopathy.
Biochemical and biophysical research communications
Sakagami Y,Kudo T,Tanimukai H,Kanayama D,Omi T,Horiguchi K,Okochi M,Imaizumi K,Takeda M
Fri Jan 11 00:00:00 UTC 2013
Essential tremor followed by progressive supranuclear palsy: postmortem reports of 11 patients.
Journal of neuropathology and experimental neurology
Louis ED,Babij R,Ma K,Cortés E,Vonsattel JP
Tue Jan 01 00:00:00 UTC 2013
Essential tremor followed by progressive supranuclear palsy: postmortem reports of 11 patients.
Journal of neuropathology and experimental neurology
Louis ED,Babij R,Ma K,Cortés E,Vonsattel JP
Tue Jan 01 00:00:00 UTC 2013
A unique mouse model for investigating the properties of amyotrophic lateral sclerosis-associated protein TDP-43, by in utero electroporation.
Neuroscience research
Akamatsu M,Takuma H,Yamashita T,Okada T,Keino-Masu K,Ishii K,Kwak S,Masu M,Tamaoka A
Sun Dec 01 00:00:00 UTC 2013
A unique mouse model for investigating the properties of amyotrophic lateral sclerosis-associated protein TDP-43, by in utero electroporation.
Neuroscience research
Akamatsu M,Takuma H,Yamashita T,Okada T,Keino-Masu K,Ishii K,Kwak S,Masu M,Tamaoka A
Sun Dec 01 00:00:00 UTC 2013
Prevalence of dementia subtypes in a developing country: a clinicopathological study.
Clinics (Sao Paulo, Brazil)
Grinberg LT,Nitrini R,Suemoto CK,Lucena Ferretti-Rebustini RE,Leite RE,Farfel JM,Santos E,Andrade MP,Alho AT,Lima Mdo C,Oliveira KC,Tampellini E,Polichiso L,Santos GB,Rodriguez RD,Ueda K,Pasqualucci CA,Jacob-Filho W
Fri May 02 00:00:00 UTC 2014
Prevalence of dementia subtypes in a developing country: a clinicopathological study.
Clinics (Sao Paulo, Brazil)
Grinberg LT,Nitrini R,Suemoto CK,Lucena Ferretti-Rebustini RE,Leite RE,Farfel JM,Santos E,Andrade MP,Alho AT,Lima Mdo C,Oliveira KC,Tampellini E,Polichiso L,Santos GB,Rodriguez RD,Ueda K,Pasqualucci CA,Jacob-Filho W
Fri May 02 00:00:00 UTC 2014
Premature death of TDP-43 (A315T) transgenic mice due to gastrointestinal complications prior to development of full neurological symptoms of amyotrophic lateral sclerosis.
International journal of experimental pathology
Esmaeili MA,Panahi M,Yadav S,Hennings L,Kiaei M
Fri Feb 01 00:00:00 UTC 2013
Premature death of TDP-43 (A315T) transgenic mice due to gastrointestinal complications prior to development of full neurological symptoms of amyotrophic lateral sclerosis.
International journal of experimental pathology
Esmaeili MA,Panahi M,Yadav S,Hennings L,Kiaei M
Fri Feb 01 00:00:00 UTC 2013
Premature death of TDP-43 (A315T) transgenic mice due to gastrointestinal complications prior to development of full neurological symptoms of amyotrophic lateral sclerosis.
International journal of experimental pathology
Esmaeili MA,Panahi M,Yadav S,Hennings L,Kiaei M
Fri Feb 01 00:00:00 UTC 2013
Premature death of TDP-43 (A315T) transgenic mice due to gastrointestinal complications prior to development of full neurological symptoms of amyotrophic lateral sclerosis.
International journal of experimental pathology
Esmaeili MA,Panahi M,Yadav S,Hennings L,Kiaei M
Fri Feb 01 00:00:00 UTC 2013
The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons.
FEBS open bio
Honda D,Ishigaki S,Iguchi Y,Fujioka Y,Udagawa T,Masuda A,Ohno K,Katsuno M,Sobue G
Mon Dec 09 00:00:00 UTC 2013
The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons.
FEBS open bio
Honda D,Ishigaki S,Iguchi Y,Fujioka Y,Udagawa T,Masuda A,Ohno K,Katsuno M,Sobue G
Mon Dec 09 00:00:00 UTC 2013
Quantitative neurofibrillary tangle density and brain volumetric MRI analyses in Alzheimer's disease presenting as logopenic progressive aphasia.
Brain and language
Josephs KA,Dickson DW,Murray ME,Senjem ML,Parisi JE,Petersen RC,Jack CR,Whitwell JL
Fri Nov 01 00:00:00 UTC 2013
Quantitative neurofibrillary tangle density and brain volumetric MRI analyses in Alzheimer's disease presenting as logopenic progressive aphasia.
Brain and language
Josephs KA,Dickson DW,Murray ME,Senjem ML,Parisi JE,Petersen RC,Jack CR,Whitwell JL
Fri Nov 01 00:00:00 UTC 2013
Patterns of striatal degeneration in frontotemporal dementia.
Alzheimer disease and associated disorders
Halabi C,Halabi A,Dean DL,Wang PN,Boxer AL,Trojanowski JQ,Dearmond SJ,Miller BL,Kramer JH,Seeley WW
Mon Aug 12 00:00:00 UTC 2013
Patterns of striatal degeneration in frontotemporal dementia.
Alzheimer disease and associated disorders
Halabi C,Halabi A,Dean DL,Wang PN,Boxer AL,Trojanowski JQ,Dearmond SJ,Miller BL,Kramer JH,Seeley WW
Mon Aug 12 00:00:00 UTC 2013
Neurocognitive speed associates with frontotemporal lobar degeneration TDP-43 subtypes.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Dean PM,Smith GE,Parisi JE,Dickson DW,Petersen RC,Josephs KA
Sun Dec 01 00:00:00 UTC 2013
Neurocognitive speed associates with frontotemporal lobar degeneration TDP-43 subtypes.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Dean PM,Smith GE,Parisi JE,Dickson DW,Petersen RC,Josephs KA
Sun Dec 01 00:00:00 UTC 2013
Surgical pathology of epilepsy-associated non-neoplastic cerebral lesions: a brief introduction with special reference to hippocampal sclerosis and focal cortical dysplasia.
Neuropathology : official journal of the Japanese Society of Neuropathology
Miyata H,Hori T,Vinters HV
Thu Aug 01 00:00:00 UTC 2013
Surgical pathology of epilepsy-associated non-neoplastic cerebral lesions: a brief introduction with special reference to hippocampal sclerosis and focal cortical dysplasia.
Neuropathology : official journal of the Japanese Society of Neuropathology
Miyata H,Hori T,Vinters HV
Thu Aug 01 00:00:00 UTC 2013
Increased number of astrocytes and macrophages/microglial cells in the corpus callosum in amyotrophic lateral sclerosis.
Neuropathology : official journal of the Japanese Society of Neuropathology
Sugiyama M,Takao M,Hatsuta H,Funabe S,Ito S,Obi T,Tanaka F,Kuroiwa Y,Murayama S
Sun Dec 01 00:00:00 UTC 2013
Increased number of astrocytes and macrophages/microglial cells in the corpus callosum in amyotrophic lateral sclerosis.
Neuropathology : official journal of the Japanese Society of Neuropathology
Sugiyama M,Takao M,Hatsuta H,Funabe S,Ito S,Obi T,Tanaka F,Kuroiwa Y,Murayama S
Sun Dec 01 00:00:00 UTC 2013
Atypical FTLD-FUS associated with ALS-TDP: a case report.
Neuropathology : official journal of the Japanese Society of Neuropathology
Kobayashi Z,Arai T,Yokota O,Tsuchiya K,Hosokawa M,Oshima K,Niizato K,Akiyama H,Mizusawa H
Fri Feb 01 00:00:00 UTC 2013
Atypical FTLD-FUS associated with ALS-TDP: a case report.
Neuropathology : official journal of the Japanese Society of Neuropathology
Kobayashi Z,Arai T,Yokota O,Tsuchiya K,Hosokawa M,Oshima K,Niizato K,Akiyama H,Mizusawa H
Fri Feb 01 00:00:00 UTC 2013
Accumulation of phosphorylated TDP-43 in the CNS of a patient with Cockayne syndrome.
Neuropathology : official journal of the Japanese Society of Neuropathology
Sakurai A,Makioka K,Fukuda T,Takatama M,Okamoto K
Sun Dec 01 00:00:00 UTC 2013
Accumulation of phosphorylated TDP-43 in the CNS of a patient with Cockayne syndrome.
Neuropathology : official journal of the Japanese Society of Neuropathology
Sakurai A,Makioka K,Fukuda T,Takatama M,Okamoto K
Sun Dec 01 00:00:00 UTC 2013
Valosin-containing protein immunoreactivity in tauopathies, synucleinopathies, polyglutamine diseases and intranuclear inclusion body disease.
Neuropathology : official journal of the Japanese Society of Neuropathology
Mori F,Tanji K,Toyoshima Y,Sasaki H,Yoshida M,Kakita A,Takahashi H,Wakabayashi K
Sun Dec 01 00:00:00 UTC 2013
Valosin-containing protein immunoreactivity in tauopathies, synucleinopathies, polyglutamine diseases and intranuclear inclusion body disease.
Neuropathology : official journal of the Japanese Society of Neuropathology
Mori F,Tanji K,Toyoshima Y,Sasaki H,Yoshida M,Kakita A,Takahashi H,Wakabayashi K
Sun Dec 01 00:00:00 UTC 2013
A fatal neuromuscular disease in an adult patient after poliomyelitis in early childhood: consideration of the pathology of post-polio syndrome.
Neuropathology : official journal of the Japanese Society of Neuropathology
Kosaka T,Kuroha Y,Tada M,Hasegawa A,Tani T,Matsubara N,Koike R,Toyoshima Y,Takahashi H
Fri Feb 01 00:00:00 UTC 2013
A fatal neuromuscular disease in an adult patient after poliomyelitis in early childhood: consideration of the pathology of post-polio syndrome.
Neuropathology : official journal of the Japanese Society of Neuropathology
Kosaka T,Kuroha Y,Tada M,Hasegawa A,Tani T,Matsubara N,Koike R,Toyoshima Y,Takahashi H
Fri Feb 01 00:00:00 UTC 2013
ApoE and TDP-43 neuropathology in two siblings with familial FTLD-motor neuron disease.
Neurocase
Vossel KA,Bien-Ly N,Bernardo A,Rascovsky K,Karydas A,Rabinovici GD,Sidhu M,Huang EJ,Miller BL,Huang Y,Seeley WW
Thu Jan 23 00:00:00 UTC 2014
ApoE and TDP-43 neuropathology in two siblings with familial FTLD-motor neuron disease.
Neurocase
Vossel KA,Bien-Ly N,Bernardo A,Rascovsky K,Karydas A,Rabinovici GD,Sidhu M,Huang EJ,Miller BL,Huang Y,Seeley WW
Thu Jan 23 00:00:00 UTC 2014
The pathogenesis of cingulate atrophy in behavioral variant frontotemporal dementia and Alzheimer's disease.
Acta neuropathologica communications
Tan RH,Pok K,Wong S,Brooks D,Halliday GM,Kril JJ
Fri Jul 05 00:00:00 UTC 2013
The pathogenesis of cingulate atrophy in behavioral variant frontotemporal dementia and Alzheimer's disease.
Acta neuropathologica communications
Tan RH,Pok K,Wong S,Brooks D,Halliday GM,Kril JJ
Fri Jul 05 00:00:00 UTC 2013
Hexanucleotide repeats in ALS/FTD form length-dependent RNA foci, sequester RNA binding proteins, and are neurotoxic.
Cell reports
Lee YB,Chen HJ,Peres JN,Gomez-Deza J,Attig J,Stalekar M,Troakes C,Nishimura AL,Scotter EL,Vance C,Adachi Y,Sardone V,Miller JW,Smith BN,Gallo JM,Ule J,Hirth F,Rogelj B,Houart C,Shaw CE
Thu Dec 12 00:00:00 UTC 2013
Hexanucleotide repeats in ALS/FTD form length-dependent RNA foci, sequester RNA binding proteins, and are neurotoxic.
Cell reports
Lee YB,Chen HJ,Peres JN,Gomez-Deza J,Attig J,Stalekar M,Troakes C,Nishimura AL,Scotter EL,Vance C,Adachi Y,Sardone V,Miller JW,Smith BN,Gallo JM,Ule J,Hirth F,Rogelj B,Houart C,Shaw CE
Thu Dec 12 00:00:00 UTC 2013
A 43-kDa TDP-43 species is present in aggregates associated with frontotemporal lobar degeneration.
PloS one
Bosque PJ,Boyer PJ,Mishra P
Mon Dec 30 00:00:00 UTC 2013
A 43-kDa TDP-43 species is present in aggregates associated with frontotemporal lobar degeneration.
PloS one
Bosque PJ,Boyer PJ,Mishra P
Mon Dec 30 00:00:00 UTC 2013
β-N-methylamino-L-alanine induces changes in both GSK3 and TDP-43 in human neuroblastoma.
The Journal of toxicological sciences
Muñoz-Saez E,de Munck E,Arahuetes RM,Solas MT,Martínez AM,Miguel BG
Wed Oct 23 00:00:00 UTC 2013
Reducing TDP-43 aggregation does not prevent its cytotoxicity.
Acta neuropathologica communications
Liu R,Yang G,Nonaka T,Arai T,Jia W,Cynader MS
Fri Aug 09 00:00:00 UTC 2013
Reducing TDP-43 aggregation does not prevent its cytotoxicity.
Acta neuropathologica communications
Liu R,Yang G,Nonaka T,Arai T,Jia W,Cynader MS
Fri Aug 09 00:00:00 UTC 2013
Reducing TDP-43 aggregation does not prevent its cytotoxicity.
Acta neuropathologica communications
Liu R,Yang G,Nonaka T,Arai T,Jia W,Cynader MS
Fri Aug 09 00:00:00 UTC 2013
Reducing TDP-43 aggregation does not prevent its cytotoxicity.
Acta neuropathologica communications
Liu R,Yang G,Nonaka T,Arai T,Jia W,Cynader MS
Fri Aug 09 00:00:00 UTC 2013
Aberrant assembly of RNA recognition motif 1 links to pathogenic conversion of TAR DNA-binding protein of 43 kDa (TDP-43).
The Journal of biological chemistry
Shodai A,Morimura T,Ido A,Uchida T,Ayaki T,Takahashi R,Kitazawa S,Suzuki S,Shirouzu M,Kigawa T,Muto Y,Yokoyama S,Takahashi R,Kitahara R,Ito H,Fujiwara N,Urushitani M
Fri May 24 00:00:00 UTC 2013
Aberrant assembly of RNA recognition motif 1 links to pathogenic conversion of TAR DNA-binding protein of 43 kDa (TDP-43).
The Journal of biological chemistry
Shodai A,Morimura T,Ido A,Uchida T,Ayaki T,Takahashi R,Kitazawa S,Suzuki S,Shirouzu M,Kigawa T,Muto Y,Yokoyama S,Takahashi R,Kitahara R,Ito H,Fujiwara N,Urushitani M
Fri May 24 00:00:00 UTC 2013
Exome sequencing identifies titin mutations causing hereditary myopathy with early respiratory failure (HMERF) in families of diverse ethnic origins.
BMC neurology
Toro C,Olivé M,Dalakas MC,Sivakumar K,Bilbao JM,Tyndel F,Vidal N,Farrero E,Sambuughin N,Goldfarb LG
Wed Mar 20 00:00:00 UTC 2013
Exome sequencing identifies titin mutations causing hereditary myopathy with early respiratory failure (HMERF) in families of diverse ethnic origins.
BMC neurology
Toro C,Olivé M,Dalakas MC,Sivakumar K,Bilbao JM,Tyndel F,Vidal N,Farrero E,Sambuughin N,Goldfarb LG
Wed Mar 20 00:00:00 UTC 2013
Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6).
The Journal of biological chemistry
Hebron ML,Lonskaya I,Sharpe K,Weerasinghe PP,Algarzae NK,Shekoyan AR,Moussa CE
Fri Feb 08 00:00:00 UTC 2013
Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6).
The Journal of biological chemistry
Hebron ML,Lonskaya I,Sharpe K,Weerasinghe PP,Algarzae NK,Shekoyan AR,Moussa CE
Fri Feb 08 00:00:00 UTC 2013
Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6).
The Journal of biological chemistry
Hebron ML,Lonskaya I,Sharpe K,Weerasinghe PP,Algarzae NK,Shekoyan AR,Moussa CE
Fri Feb 08 00:00:00 UTC 2013
Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6).
The Journal of biological chemistry
Hebron ML,Lonskaya I,Sharpe K,Weerasinghe PP,Algarzae NK,Shekoyan AR,Moussa CE
Fri Feb 08 00:00:00 UTC 2013
Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6).
The Journal of biological chemistry
Hebron ML,Lonskaya I,Sharpe K,Weerasinghe PP,Algarzae NK,Shekoyan AR,Moussa CE
Fri Feb 08 00:00:00 UTC 2013
Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6).
The Journal of biological chemistry
Hebron ML,Lonskaya I,Sharpe K,Weerasinghe PP,Algarzae NK,Shekoyan AR,Moussa CE
Fri Feb 08 00:00:00 UTC 2013
Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6).
The Journal of biological chemistry
Hebron ML,Lonskaya I,Sharpe K,Weerasinghe PP,Algarzae NK,Shekoyan AR,Moussa CE
Fri Feb 08 00:00:00 UTC 2013
Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6).
The Journal of biological chemistry
Hebron ML,Lonskaya I,Sharpe K,Weerasinghe PP,Algarzae NK,Shekoyan AR,Moussa CE
Fri Feb 08 00:00:00 UTC 2013
Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6).
The Journal of biological chemistry
Hebron ML,Lonskaya I,Sharpe K,Weerasinghe PP,Algarzae NK,Shekoyan AR,Moussa CE
Fri Feb 08 00:00:00 UTC 2013
Identification of in vivo, conserved, TAF15 RNA binding sites reveals the impact of TAF15 on the neuronal transcriptome.
Cell reports
Ibrahim F,Maragkakis M,Alexiou P,Maronski MA,Dichter MA,Mourelatos Z
Thu Feb 21 00:00:00 UTC 2013
Identification of in vivo, conserved, TAF15 RNA binding sites reveals the impact of TAF15 on the neuronal transcriptome.
Cell reports
Ibrahim F,Maragkakis M,Alexiou P,Maronski MA,Dichter MA,Mourelatos Z
Thu Feb 21 00:00:00 UTC 2013
Non-targeted identification of prions and amyloid-forming proteins from yeast and mammalian cells.
The Journal of biological chemistry
Kryndushkin D,Pripuzova N,Burnett BG,Shewmaker F
Fri Sep 20 00:00:00 UTC 2013
Non-targeted identification of prions and amyloid-forming proteins from yeast and mammalian cells.
The Journal of biological chemistry
Kryndushkin D,Pripuzova N,Burnett BG,Shewmaker F
Fri Sep 20 00:00:00 UTC 2013
Identification of genetic modifiers of TDP-43 neurotoxicity in Drosophila.
PloS one
Zhan L,Hanson KA,Kim SH,Tare A,Tibbetts RS
Tue Sep 10 00:00:00 UTC 2013
Identification of genetic modifiers of TDP-43 neurotoxicity in Drosophila.
PloS one
Zhan L,Hanson KA,Kim SH,Tare A,Tibbetts RS
Tue Sep 10 00:00:00 UTC 2013
Identification of genetic modifiers of TDP-43 neurotoxicity in Drosophila.
PloS one
Zhan L,Hanson KA,Kim SH,Tare A,Tibbetts RS
Tue Sep 10 00:00:00 UTC 2013
Identification of genetic modifiers of TDP-43 neurotoxicity in Drosophila.
PloS one
Zhan L,Hanson KA,Kim SH,Tare A,Tibbetts RS
Tue Sep 10 00:00:00 UTC 2013
Comparative utility of LC3, p62 and TDP-43 immunohistochemistry in differentiation of inclusion body myositis from polymyositis and related inflammatory myopathies.
Acta neuropathologica communications
Hiniker A,Daniels BH,Lee HS,Margeta M
Mon Jul 01 00:00:00 UTC 2013
ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation.
PloS one
Walker AK,Soo KY,Sundaramoorthy V,Parakh S,Ma Y,Farg MA,Wallace RH,Crouch PJ,Turner BJ,Horne MK,Atkin JD
Wed Dec 17 00:00:00 UTC 2014
ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation.
PloS one
Walker AK,Soo KY,Sundaramoorthy V,Parakh S,Ma Y,Farg MA,Wallace RH,Crouch PJ,Turner BJ,Horne MK,Atkin JD
Wed Dec 17 00:00:00 UTC 2014
Ubiquilin-2 (UBQLN2) binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells: characterization of inhibition by nucleic acids and 4-aminoquinolines.
Biochimica et biophysica acta
Cassel JA,Reitz AB
Sat Jun 01 00:00:00 UTC 2013
Ubiquilin-2 (UBQLN2) binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells: characterization of inhibition by nucleic acids and 4-aminoquinolines.
Biochimica et biophysica acta
Cassel JA,Reitz AB
Sat Jun 01 00:00:00 UTC 2013
Classification of FTLD-TDP cases into pathological subtypes using antibodies against phosphorylated and non-phosphorylated TDP43.
Acta neuropathologica communications
Tan RH,Shepherd CE,Kril JJ,McCann H,McGeachie A,McGinley C,Affleck A,Halliday GM
Wed Jul 10 00:00:00 UTC 2013
Classification of FTLD-TDP cases into pathological subtypes using antibodies against phosphorylated and non-phosphorylated TDP43.
Acta neuropathologica communications
Tan RH,Shepherd CE,Kril JJ,McCann H,McGeachie A,McGinley C,Affleck A,Halliday GM
Wed Jul 10 00:00:00 UTC 2013
Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress.
PloS one
Moujalled D,James JL,Parker SJ,Lidgerwood GE,Duncan C,Meyerowitz J,Nonaka T,Hasegawa M,Kanninen KM,Grubman A,Liddell JR,Crouch PJ,White AR
Mon Oct 16 00:00:00 UTC 2017
Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress.
PloS one
Moujalled D,James JL,Parker SJ,Lidgerwood GE,Duncan C,Meyerowitz J,Nonaka T,Hasegawa M,Kanninen KM,Grubman A,Liddell JR,Crouch PJ,White AR
Mon Oct 16 00:00:00 UTC 2017
Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice.
Molecular neurodegeneration
Qiu L,Qiao T,Beers M,Tan W,Wang H,Yang B,Xu Z
Thu Jan 03 00:00:00 UTC 2013
Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice.
Molecular neurodegeneration
Qiu L,Qiao T,Beers M,Tan W,Wang H,Yang B,Xu Z
Thu Jan 03 00:00:00 UTC 2013
RNP2 of RNA recognition motif 1 plays a central role in the aberrant modification of TDP-43.
PloS one
Takagi S,Iguchi Y,Katsuno M,Ishigaki S,Ikenaka K,Fujioka Y,Honda D,Niwa J,Tanaka F,Watanabe H,Adachi H,Sobue G
Tue Jan 21 00:00:00 UTC 2014
RNP2 of RNA recognition motif 1 plays a central role in the aberrant modification of TDP-43.
PloS one
Takagi S,Iguchi Y,Katsuno M,Ishigaki S,Ikenaka K,Fujioka Y,Honda D,Niwa J,Tanaka F,Watanabe H,Adachi H,Sobue G
Tue Jan 21 00:00:00 UTC 2014
RNP2 of RNA recognition motif 1 plays a central role in the aberrant modification of TDP-43.
PloS one
Takagi S,Iguchi Y,Katsuno M,Ishigaki S,Ikenaka K,Fujioka Y,Honda D,Niwa J,Tanaka F,Watanabe H,Adachi H,Sobue G
Tue Jan 21 00:00:00 UTC 2014
RNP2 of RNA recognition motif 1 plays a central role in the aberrant modification of TDP-43.
PloS one
Takagi S,Iguchi Y,Katsuno M,Ishigaki S,Ikenaka K,Fujioka Y,Honda D,Niwa J,Tanaka F,Watanabe H,Adachi H,Sobue G
Tue Jan 21 00:00:00 UTC 2014
Genetic CJD with a novel E200G mutation in the prion protein gene and comparison with E200K mutation cases.
Acta neuropathologica communications
Kim MO,Cali I,Oehler A,Fong JC,Wong K,See T,Katz JS,Gambetti P,Bettcher BM,Dearmond SJ,Geschwind MD
Thu Dec 12 00:00:00 UTC 2013
Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations.
PloS one
Zhang Z,Almeida S,Lu Y,Nishimura AL,Peng L,Sun D,Wu B,Karydas AM,Tartaglia MC,Fong JC,Miller BL,Farese RV,Moore MJ,Shaw CE,Gao FB
Tue Jun 17 00:00:00 UTC 2014
Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations.
PloS one
Zhang Z,Almeida S,Lu Y,Nishimura AL,Peng L,Sun D,Wu B,Karydas AM,Tartaglia MC,Fong JC,Miller BL,Farese RV,Moore MJ,Shaw CE,Gao FB
Tue Jun 17 00:00:00 UTC 2014
Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations.
PloS one
Zhang Z,Almeida S,Lu Y,Nishimura AL,Peng L,Sun D,Wu B,Karydas AM,Tartaglia MC,Fong JC,Miller BL,Farese RV,Moore MJ,Shaw CE,Gao FB
Tue Jun 17 00:00:00 UTC 2014
Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations.
PloS one
Zhang Z,Almeida S,Lu Y,Nishimura AL,Peng L,Sun D,Wu B,Karydas AM,Tartaglia MC,Fong JC,Miller BL,Farese RV,Moore MJ,Shaw CE,Gao FB
Tue Jun 17 00:00:00 UTC 2014
The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis.
Molecular brain
Nishimoto Y,Nakagawa S,Hirose T,Okano HJ,Takao M,Shibata S,Suyama S,Kuwako K,Imai T,Murayama S,Suzuki N,Okano H
Mon Jul 08 00:00:00 UTC 2013
The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis.
Molecular brain
Nishimoto Y,Nakagawa S,Hirose T,Okano HJ,Takao M,Shibata S,Suyama S,Kuwako K,Imai T,Murayama S,Suzuki N,Okano H
Mon Jul 08 00:00:00 UTC 2013
The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis.
Molecular brain
Nishimoto Y,Nakagawa S,Hirose T,Okano HJ,Takao M,Shibata S,Suyama S,Kuwako K,Imai T,Murayama S,Suzuki N,Okano H
Mon Jul 08 00:00:00 UTC 2013
The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis.
Molecular brain
Nishimoto Y,Nakagawa S,Hirose T,Okano HJ,Takao M,Shibata S,Suyama S,Kuwako K,Imai T,Murayama S,Suzuki N,Okano H
Mon Jul 08 00:00:00 UTC 2013
The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis.
Molecular brain
Nishimoto Y,Nakagawa S,Hirose T,Okano HJ,Takao M,Shibata S,Suyama S,Kuwako K,Imai T,Murayama S,Suzuki N,Okano H
Mon Jul 08 00:00:00 UTC 2013
Hippocampal sclerosis dementia: An amnesic variant of frontotemporal degeneration.
Dementia & neuropsychologia
Onyike CU,Pletnikova O,Sloane KL,Sullivan C,Troncoso JC,Rabins PV
Fri Mar 01 00:00:00 UTC 2013
Hippocampal sclerosis dementia: An amnesic variant of frontotemporal degeneration.
Dementia & neuropsychologia
Onyike CU,Pletnikova O,Sloane KL,Sullivan C,Troncoso JC,Rabins PV
Fri Mar 01 00:00:00 UTC 2013
Extensive aggregation of α-synuclein and tau in juvenile-onset neuroaxonal dystrophy: an autopsied individual with a novel mutation in the PLA2G6 gene-splicing site.
Acta neuropathologica communications
Riku Y,Ikeuchi T,Yoshino H,Mimuro M,Mano K,Goto Y,Hattori N,Sobue G,Yoshida M
Thu May 09 00:00:00 UTC 2013
Extensive aggregation of α-synuclein and tau in juvenile-onset neuroaxonal dystrophy: an autopsied individual with a novel mutation in the PLA2G6 gene-splicing site.
Acta neuropathologica communications
Riku Y,Ikeuchi T,Yoshino H,Mimuro M,Mano K,Goto Y,Hattori N,Sobue G,Yoshida M
Thu May 09 00:00:00 UTC 2013
Characterization of the distal polyadenylation site of the ß-adducin (Add2) pre-mRNA.
PloS one
Costessi L,Porro F,Iaconcig A,Nedeljkovic M,Muro AF
Thu Oct 17 00:00:00 UTC 2013
Characterization of the distal polyadenylation site of the ß-adducin (Add2) pre-mRNA.
PloS one
Costessi L,Porro F,Iaconcig A,Nedeljkovic M,Muro AF
Thu Oct 17 00:00:00 UTC 2013
Prion-like properties of pathological TDP-43 aggregates from diseased brains.
Cell reports
Nonaka T,Masuda-Suzukake M,Arai T,Hasegawa Y,Akatsu H,Obi T,Yoshida M,Murayama S,Mann DM,Akiyama H,Hasegawa M
Thu Jul 11 00:00:00 UTC 2013
The truncated C-terminal RNA recognition motif of TDP-43 protein plays a key role in forming proteinaceous aggregates.
The Journal of biological chemistry
Wang YT,Kuo PH,Chiang CH,Liang JR,Chen YR,Wang S,Shen JC,Yuan HS
Fri Mar 29 00:00:00 UTC 2013
The truncated C-terminal RNA recognition motif of TDP-43 protein plays a key role in forming proteinaceous aggregates.
The Journal of biological chemistry
Wang YT,Kuo PH,Chiang CH,Liang JR,Chen YR,Wang S,Shen JC,Yuan HS
Fri Mar 29 00:00:00 UTC 2013
Early and selective reduction of NOP56 (Asidan) and RNA processing proteins in the motor neuron of ALS model mice.
Neurological research
Miyazaki K,Yamashita T,Morimoto N,Sato K,Mimoto T,Kurata T,Ikeda Y,Abe K
Sun Sep 01 00:00:00 UTC 2013
Early and selective reduction of NOP56 (Asidan) and RNA processing proteins in the motor neuron of ALS model mice.
Neurological research
Miyazaki K,Yamashita T,Morimoto N,Sato K,Mimoto T,Kurata T,Ikeda Y,Abe K
Sun Sep 01 00:00:00 UTC 2013
TDP-43, an ALS linked protein, regulates fat deposition and glucose homeostasis.
PloS one
Stallings NR,Puttaparthi K,Dowling KJ,Luther CM,Burns DK,Davis K,Elliott JL
Wed May 14 00:00:00 UTC 2014
TDP-43, an ALS linked protein, regulates fat deposition and glucose homeostasis.
PloS one
Stallings NR,Puttaparthi K,Dowling KJ,Luther CM,Burns DK,Davis K,Elliott JL
Wed May 14 00:00:00 UTC 2014
Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis.
Nature
Wu CH,Fallini C,Ticozzi N,Keagle PJ,Sapp PC,Piotrowska K,Lowe P,Koppers M,McKenna-Yasek D,Baron DM,Kost JE,Gonzalez-Perez P,Fox AD,Adams J,Taroni F,Tiloca C,Leclerc AL,Chafe SC,Mangroo D,Moore MJ,Zitzewitz JA,Xu ZS,van den Berg LH,Glass JD,Siciliano G,Cirulli ET,Goldstein DB,Salachas F,Meininger V,Rossoll W,Ratti A,Gellera C,Bosco DA,Bassell GJ,Silani V,Drory VE,Brown RH,Landers JE
Thu Aug 23 00:00:00 UTC 2012
Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis.
Nature
Wu CH,Fallini C,Ticozzi N,Keagle PJ,Sapp PC,Piotrowska K,Lowe P,Koppers M,McKenna-Yasek D,Baron DM,Kost JE,Gonzalez-Perez P,Fox AD,Adams J,Taroni F,Tiloca C,Leclerc AL,Chafe SC,Mangroo D,Moore MJ,Zitzewitz JA,Xu ZS,van den Berg LH,Glass JD,Siciliano G,Cirulli ET,Goldstein DB,Salachas F,Meininger V,Rossoll W,Ratti A,Gellera C,Bosco DA,Bassell GJ,Silani V,Drory VE,Brown RH,Landers JE
Thu Aug 23 00:00:00 UTC 2012
A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: a gene identification study.
The Lancet. Neurology
Gijselinck I,Van Langenhove T,van der Zee J,Sleegers K,Philtjens S,Kleinberger G,Janssens J,Bettens K,Van Cauwenberghe C,Pereson S,Engelborghs S,Sieben A,De Jonghe P,Vandenberghe R,Santens P,De Bleecker J,Maes G,Bäumer V,Dillen L,Joris G,Cuijt I,Corsmit E,Elinck E,Van Dongen J,Vermeulen S,Van den Broeck M,Vaerenberg C,Mattheijssens M,Peeters K,Robberecht W,Cras P,Martin JJ,De Deyn PP,Cruts M,Van Broeckhoven C
Sun Jan 01 00:00:00 UTC 2012
A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: a gene identification study.
The Lancet. Neurology
Gijselinck I,Van Langenhove T,van der Zee J,Sleegers K,Philtjens S,Kleinberger G,Janssens J,Bettens K,Van Cauwenberghe C,Pereson S,Engelborghs S,Sieben A,De Jonghe P,Vandenberghe R,Santens P,De Bleecker J,Maes G,Bäumer V,Dillen L,Joris G,Cuijt I,Corsmit E,Elinck E,Van Dongen J,Vermeulen S,Van den Broeck M,Vaerenberg C,Mattheijssens M,Peeters K,Robberecht W,Cras P,Martin JJ,De Deyn PP,Cruts M,Van Broeckhoven C
Sun Jan 01 00:00:00 UTC 2012
Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs.
Nature neuroscience
Lagier-Tourenne C,Polymenidou M,Hutt KR,Vu AQ,Baughn M,Huelga SC,Clutario KM,Ling SC,Liang TY,Mazur C,Wancewicz E,Kim AS,Watt A,Freier S,Hicks GG,Donohue JP,Shiue L,Bennett CF,Ravits J,Cleveland DW,Yeo GW
Thu Nov 01 00:00:00 UTC 2012
Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs.
Nature neuroscience
Lagier-Tourenne C,Polymenidou M,Hutt KR,Vu AQ,Baughn M,Huelga SC,Clutario KM,Ling SC,Liang TY,Mazur C,Wancewicz E,Kim AS,Watt A,Freier S,Hicks GG,Donohue JP,Shiue L,Bennett CF,Ravits J,Cleveland DW,Yeo GW
Thu Nov 01 00:00:00 UTC 2012
Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs.
Nature neuroscience
Lagier-Tourenne C,Polymenidou M,Hutt KR,Vu AQ,Baughn M,Huelga SC,Clutario KM,Ling SC,Liang TY,Mazur C,Wancewicz E,Kim AS,Watt A,Freier S,Hicks GG,Donohue JP,Shiue L,Bennett CF,Ravits J,Cleveland DW,Yeo GW
Thu Nov 01 00:00:00 UTC 2012
Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs.
Nature neuroscience
Lagier-Tourenne C,Polymenidou M,Hutt KR,Vu AQ,Baughn M,Huelga SC,Clutario KM,Ling SC,Liang TY,Mazur C,Wancewicz E,Kim AS,Watt A,Freier S,Hicks GG,Donohue JP,Shiue L,Bennett CF,Ravits J,Cleveland DW,Yeo GW
Thu Nov 01 00:00:00 UTC 2012
Drug screening for ALS using patient-specific induced pluripotent stem cells.
Science translational medicine
Egawa N,Kitaoka S,Tsukita K,Naitoh M,Takahashi K,Yamamoto T,Adachi F,Kondo T,Okita K,Asaka I,Aoi T,Watanabe A,Yamada Y,Morizane A,Takahashi J,Ayaki T,Ito H,Yoshikawa K,Yamawaki S,Suzuki S,Watanabe D,Hioki H,Kaneko T,Makioka K,Okamoto K,Takuma H,Tamaoka A,Hasegawa K,Nonaka T,Hasegawa M,Kawata A,Yoshida M,Nakahata T,Takahashi R,Marchetto MC,Gage FH,Yamanaka S,Inoue H
Wed Aug 01 00:00:00 UTC 2012
Drug screening for ALS using patient-specific induced pluripotent stem cells.
Science translational medicine
Egawa N,Kitaoka S,Tsukita K,Naitoh M,Takahashi K,Yamamoto T,Adachi F,Kondo T,Okita K,Asaka I,Aoi T,Watanabe A,Yamada Y,Morizane A,Takahashi J,Ayaki T,Ito H,Yoshikawa K,Yamawaki S,Suzuki S,Watanabe D,Hioki H,Kaneko T,Makioka K,Okamoto K,Takuma H,Tamaoka A,Hasegawa K,Nonaka T,Hasegawa M,Kawata A,Yoshida M,Nakahata T,Takahashi R,Marchetto MC,Gage FH,Yamanaka S,Inoue H
Wed Aug 01 00:00:00 UTC 2012
Drug screening for ALS using patient-specific induced pluripotent stem cells.
Science translational medicine
Egawa N,Kitaoka S,Tsukita K,Naitoh M,Takahashi K,Yamamoto T,Adachi F,Kondo T,Okita K,Asaka I,Aoi T,Watanabe A,Yamada Y,Morizane A,Takahashi J,Ayaki T,Ito H,Yoshikawa K,Yamawaki S,Suzuki S,Watanabe D,Hioki H,Kaneko T,Makioka K,Okamoto K,Takuma H,Tamaoka A,Hasegawa K,Nonaka T,Hasegawa M,Kawata A,Yoshida M,Nakahata T,Takahashi R,Marchetto MC,Gage FH,Yamanaka S,Inoue H
Wed Aug 01 00:00:00 UTC 2012
Drug screening for ALS using patient-specific induced pluripotent stem cells.
Science translational medicine
Egawa N,Kitaoka S,Tsukita K,Naitoh M,Takahashi K,Yamamoto T,Adachi F,Kondo T,Okita K,Asaka I,Aoi T,Watanabe A,Yamada Y,Morizane A,Takahashi J,Ayaki T,Ito H,Yoshikawa K,Yamawaki S,Suzuki S,Watanabe D,Hioki H,Kaneko T,Makioka K,Okamoto K,Takuma H,Tamaoka A,Hasegawa K,Nonaka T,Hasegawa M,Kawata A,Yoshida M,Nakahata T,Takahashi R,Marchetto MC,Gage FH,Yamanaka S,Inoue H
Wed Aug 01 00:00:00 UTC 2012
TDP-43 regulates global translational yield by splicing of exon junction complex component SKAR.
Nucleic acids research
Fiesel FC,Weber SS,Supper J,Zell A,Kahle PJ
Thu Mar 01 00:00:00 UTC 2012
TDP-43 regulates global translational yield by splicing of exon junction complex component SKAR.
Nucleic acids research
Fiesel FC,Weber SS,Supper J,Zell A,Kahle PJ
Thu Mar 01 00:00:00 UTC 2012
Convergent transcription induces transcriptional gene silencing in fission yeast and mammalian cells.
Nature structural & molecular biology
Gullerova M,Proudfoot NJ
Thu Nov 01 00:00:00 UTC 2012
Convergent transcription induces transcriptional gene silencing in fission yeast and mammalian cells.
Nature structural & molecular biology
Gullerova M,Proudfoot NJ
Thu Nov 01 00:00:00 UTC 2012
National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach.
Acta neuropathologica
Montine TJ,Phelps CH,Beach TG,Bigio EH,Cairns NJ,Dickson DW,Duyckaerts C,Frosch MP,Masliah E,Mirra SS,Nelson PT,Schneider JA,Thal DR,Trojanowski JQ,Vinters HV,Hyman BT
Sun Jan 01 00:00:00 UTC 2012
National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach.
Acta neuropathologica
Montine TJ,Phelps CH,Beach TG,Bigio EH,Cairns NJ,Dickson DW,Duyckaerts C,Frosch MP,Masliah E,Mirra SS,Nelson PT,Schneider JA,Thal DR,Trojanowski JQ,Vinters HV,Hyman BT
Sun Jan 01 00:00:00 UTC 2012
Clinical and pathological features of amyotrophic lateral sclerosis caused by mutation in the C9ORF72 gene on chromosome 9p.
Acta neuropathologica
Stewart H,Rutherford NJ,Briemberg H,Krieger C,Cashman N,Fabros M,Baker M,Fok A,DeJesus-Hernandez M,Eisen A,Rademakers R,Mackenzie IR
Thu Mar 01 00:00:00 UTC 2012
Clinical and pathological features of amyotrophic lateral sclerosis caused by mutation in the C9ORF72 gene on chromosome 9p.
Acta neuropathologica
Stewart H,Rutherford NJ,Briemberg H,Krieger C,Cashman N,Fabros M,Baker M,Fok A,DeJesus-Hernandez M,Eisen A,Rademakers R,Mackenzie IR
Thu Mar 01 00:00:00 UTC 2012
The RNA-binding motif 45 (RBM45) protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients.
Acta neuropathologica
Collins M,Riascos D,Kovalik T,An J,Krupa K,Krupa K,Hood BL,Conrads TP,Renton AE,Traynor BJ,Bowser R
Thu Nov 01 00:00:00 UTC 2012
The RNA-binding motif 45 (RBM45) protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients.
Acta neuropathologica
Collins M,Riascos D,Kovalik T,An J,Krupa K,Krupa K,Hood BL,Conrads TP,Renton AE,Traynor BJ,Bowser R
Thu Nov 01 00:00:00 UTC 2012
The RNA-binding motif 45 (RBM45) protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients.
Acta neuropathologica
Collins M,Riascos D,Kovalik T,An J,Krupa K,Krupa K,Hood BL,Conrads TP,Renton AE,Traynor BJ,Bowser R
Thu Nov 01 00:00:00 UTC 2012
The RNA-binding motif 45 (RBM45) protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients.
Acta neuropathologica
Collins M,Riascos D,Kovalik T,An J,Krupa K,Krupa K,Hood BL,Conrads TP,Renton AE,Traynor BJ,Bowser R
Thu Nov 01 00:00:00 UTC 2012
Distinct TDP-43 pathology in ALS patients with ataxin 2 intermediate-length polyQ expansions.
Acta neuropathologica
Hart MP,Brettschneider J,Lee VM,Trojanowski JQ,Gitler AD
Wed Aug 01 00:00:00 UTC 2012
Distinct TDP-43 pathology in ALS patients with ataxin 2 intermediate-length polyQ expansions.
Acta neuropathologica
Hart MP,Brettschneider J,Lee VM,Trojanowski JQ,Gitler AD
Wed Aug 01 00:00:00 UTC 2012
Coexistence of Huntington's disease and amyotrophic lateral sclerosis: a clinicopathologic study.
Acta neuropathologica
Tada M,Coon EA,Osmand AP,Kirby PA,Martin W,Wieler M,Shiga A,Shirasaki H,Tada M,Makifuchi T,Yamada M,Kakita A,Nishizawa M,Takahashi H,Paulson HL
Thu Nov 01 00:00:00 UTC 2012
Coexistence of Huntington's disease and amyotrophic lateral sclerosis: a clinicopathologic study.
Acta neuropathologica
Tada M,Coon EA,Osmand AP,Kirby PA,Martin W,Wieler M,Shiga A,Shirasaki H,Tada M,Makifuchi T,Yamada M,Kakita A,Nishizawa M,Takahashi H,Paulson HL
Thu Nov 01 00:00:00 UTC 2012
TDP-43 pathology in a case of hereditary spastic paraplegia with a NIPA1/SPG6 mutation.
Acta neuropathologica
Martinez-Lage M,Molina-Porcel L,Falcone D,McCluskey L,Lee VM,Van Deerlin VM,Trojanowski JQ
Wed Aug 01 00:00:00 UTC 2012
TDP-43 pathology in a case of hereditary spastic paraplegia with a NIPA1/SPG6 mutation.
Acta neuropathologica
Martinez-Lage M,Molina-Porcel L,Falcone D,McCluskey L,Lee VM,Van Deerlin VM,Trojanowski JQ
Wed Aug 01 00:00:00 UTC 2012
Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43.
Brain : a journal of neurology
Uchida A,Sasaguri H,Kimura N,Tajiri M,Ohkubo T,Ono F,Sakaue F,Kanai K,Hirai T,Sano T,Shibuya K,Kobayashi M,Yamamoto M,Yokota S,Kubodera T,Tomori M,Sakaki K,Enomoto M,Hirai Y,Kumagai J,Yasutomi Y,Mochizuki H,Kuwabara S,Uchihara T,Mizusawa H,Yokota T
Thu Mar 01 00:00:00 UTC 2012
Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43.
Brain : a journal of neurology
Uchida A,Sasaguri H,Kimura N,Tajiri M,Ohkubo T,Ono F,Sakaue F,Kanai K,Hirai T,Sano T,Shibuya K,Kobayashi M,Yamamoto M,Yokota S,Kubodera T,Tomori M,Sakaki K,Enomoto M,Hirai Y,Kumagai J,Yasutomi Y,Mochizuki H,Kuwabara S,Uchihara T,Mizusawa H,Yokota T
Thu Mar 01 00:00:00 UTC 2012
Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43.
Brain : a journal of neurology
Uchida A,Sasaguri H,Kimura N,Tajiri M,Ohkubo T,Ono F,Sakaue F,Kanai K,Hirai T,Sano T,Shibuya K,Kobayashi M,Yamamoto M,Yokota S,Kubodera T,Tomori M,Sakaki K,Enomoto M,Hirai Y,Kumagai J,Yasutomi Y,Mochizuki H,Kuwabara S,Uchihara T,Mizusawa H,Yokota T
Thu Mar 01 00:00:00 UTC 2012
In vivo and post-mortem memory circuit integrity in frontotemporal dementia and Alzheimer's disease.
Brain : a journal of neurology
Hornberger M,Wong S,Tan R,Irish M,Piguet O,Kril J,Hodges JR,Halliday G
Mon Oct 01 00:00:00 UTC 2012
In vivo and post-mortem memory circuit integrity in frontotemporal dementia and Alzheimer's disease.
Brain : a journal of neurology
Hornberger M,Wong S,Tan R,Irish M,Piguet O,Kril J,Hodges JR,Halliday G
Mon Oct 01 00:00:00 UTC 2012
Progressive neuronal inclusion formation and axonal degeneration in CHMP2B mutant transgenic mice.
Brain : a journal of neurology
Ghazi-Noori S,Froud KE,Mizielinska S,Powell C,Smidak M,Fernandez de Marco M,O'Malley C,Farmer M,Parkinson N,Fisher EM,Asante EA,Brandner S,Collinge J,Isaacs AM
Thu Mar 01 00:00:00 UTC 2012
Progressive neuronal inclusion formation and axonal degeneration in CHMP2B mutant transgenic mice.
Brain : a journal of neurology
Ghazi-Noori S,Froud KE,Mizielinska S,Powell C,Smidak M,Fernandez de Marco M,O'Malley C,Farmer M,Parkinson N,Fisher EM,Asante EA,Brandner S,Collinge J,Isaacs AM
Thu Mar 01 00:00:00 UTC 2012
Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations.
Brain : a journal of neurology
Snowden JS,Rollinson S,Thompson JC,Harris JM,Stopford CL,Richardson AM,Jones M,Gerhard A,Davidson YS,Robinson A,Gibbons L,Hu Q,DuPlessis D,Neary D,Mann DM,Pickering-Brown SM
Thu Mar 01 00:00:00 UTC 2012
Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations.
Brain : a journal of neurology
Snowden JS,Rollinson S,Thompson JC,Harris JM,Stopford CL,Richardson AM,Jones M,Gerhard A,Davidson YS,Robinson A,Gibbons L,Hu Q,DuPlessis D,Neary D,Mann DM,Pickering-Brown SM
Thu Mar 01 00:00:00 UTC 2012
Clinical and pathological features of familial frontotemporal dementia caused by C9ORF72 mutation on chromosome 9p.
Brain : a journal of neurology
Hsiung GY,DeJesus-Hernandez M,Feldman HH,Sengdy P,Bouchard-Kerr P,Dwosh E,Butler R,Leung B,Fok A,Rutherford NJ,Baker M,Rademakers R,Mackenzie IR
Thu Mar 01 00:00:00 UTC 2012
Clinical and pathological features of familial frontotemporal dementia caused by C9ORF72 mutation on chromosome 9p.
Brain : a journal of neurology
Hsiung GY,DeJesus-Hernandez M,Feldman HH,Sengdy P,Bouchard-Kerr P,Dwosh E,Butler R,Leung B,Fok A,Rutherford NJ,Baker M,Rademakers R,Mackenzie IR
Thu Mar 01 00:00:00 UTC 2012
Molecular analysis and biochemical classification of TDP-43 proteinopathy.
Brain : a journal of neurology
Tsuji H,Arai T,Kametani F,Nonaka T,Yamashita M,Suzukake M,Hosokawa M,Yoshida M,Hatsuta H,Takao M,Saito Y,Murayama S,Akiyama H,Hasegawa M,Mann DM,Tamaoka A
Thu Nov 01 00:00:00 UTC 2012
Molecular analysis and biochemical classification of TDP-43 proteinopathy.
Brain : a journal of neurology
Tsuji H,Arai T,Kametani F,Nonaka T,Yamashita M,Suzukake M,Hosokawa M,Yoshida M,Hatsuta H,Takao M,Saito Y,Murayama S,Akiyama H,Hasegawa M,Mann DM,Tamaoka A
Thu Nov 01 00:00:00 UTC 2012
Long non-coding RNA gadd7 interacts with TDP-43 and regulates Cdk6 mRNA decay.
The EMBO journal
Liu X,Li D,Zhang W,Guo M,Zhan Q
Wed Nov 28 00:00:00 UTC 2012
Long non-coding RNA gadd7 interacts with TDP-43 and regulates Cdk6 mRNA decay.
The EMBO journal
Liu X,Li D,Zhang W,Guo M,Zhan Q
Wed Nov 28 00:00:00 UTC 2012
Long non-coding RNA gadd7 interacts with TDP-43 and regulates Cdk6 mRNA decay.
The EMBO journal
Liu X,Li D,Zhang W,Guo M,Zhan Q
Wed Nov 28 00:00:00 UTC 2012
Long non-coding RNA gadd7 interacts with TDP-43 and regulates Cdk6 mRNA decay.
The EMBO journal
Liu X,Li D,Zhang W,Guo M,Zhan Q
Wed Nov 28 00:00:00 UTC 2012
Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking.
The EMBO journal
Cohen TJ,Hwang AW,Unger T,Trojanowski JQ,Lee VM
Wed Mar 07 00:00:00 UTC 2012
Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking.
The EMBO journal
Cohen TJ,Hwang AW,Unger T,Trojanowski JQ,Lee VM
Wed Mar 07 00:00:00 UTC 2012
Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking.
The EMBO journal
Cohen TJ,Hwang AW,Unger T,Trojanowski JQ,Lee VM
Wed Mar 07 00:00:00 UTC 2012
Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking.
The EMBO journal
Cohen TJ,Hwang AW,Unger T,Trojanowski JQ,Lee VM
Wed Mar 07 00:00:00 UTC 2012
Autoregulation of TDP-43 mRNA levels involves interplay between transcription, splicing, and alternative polyA site selection.
Genes & development
Avendaño-Vázquez SE,Dhir A,Bembich S,Buratti E,Proudfoot N,Baralle FE
Wed Aug 01 00:00:00 UTC 2012
Autoregulation of TDP-43 mRNA levels involves interplay between transcription, splicing, and alternative polyA site selection.
Genes & development
Avendaño-Vázquez SE,Dhir A,Bembich S,Buratti E,Proudfoot N,Baralle FE
Wed Aug 01 00:00:00 UTC 2012
Autoregulation of TDP-43 mRNA levels involves interplay between transcription, splicing, and alternative polyA site selection.
Genes & development
Avendaño-Vázquez SE,Dhir A,Bembich S,Buratti E,Proudfoot N,Baralle FE
Wed Aug 01 00:00:00 UTC 2012
Autoregulation of TDP-43 mRNA levels involves interplay between transcription, splicing, and alternative polyA site selection.
Genes & development
Avendaño-Vázquez SE,Dhir A,Bembich S,Buratti E,Proudfoot N,Baralle FE
Wed Aug 01 00:00:00 UTC 2012
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability.
Proceedings of the National Academy of Sciences of the United States of America
Bilican B,Serio A,Barmada SJ,Nishimura AL,Sullivan GJ,Carrasco M,Phatnani HP,Puddifoot CA,Story D,Fletcher J,Park IH,Friedman BA,Daley GQ,Wyllie DJ,Hardingham GE,Wilmut I,Finkbeiner S,Maniatis T,Shaw CE,Chandran S
Tue Apr 10 00:00:00 UTC 2012
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability.
Proceedings of the National Academy of Sciences of the United States of America
Bilican B,Serio A,Barmada SJ,Nishimura AL,Sullivan GJ,Carrasco M,Phatnani HP,Puddifoot CA,Story D,Fletcher J,Park IH,Friedman BA,Daley GQ,Wyllie DJ,Hardingham GE,Wilmut I,Finkbeiner S,Maniatis T,Shaw CE,Chandran S
Tue Apr 10 00:00:00 UTC 2012
TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes.
Proceedings of the National Academy of Sciences of the United States of America
Kawahara Y,Mieda-Sato A
Tue Feb 28 00:00:00 UTC 2012
TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes.
Proceedings of the National Academy of Sciences of the United States of America
Kawahara Y,Mieda-Sato A
Tue Feb 28 00:00:00 UTC 2012
Reduced expression of BTBD10, an Akt activator, leads to motor neuron death.
Cell death and differentiation
Nawa M,Kage-Nakadai E,Aiso S,Okamoto K,Mitani S,Matsuoka M
Wed Aug 01 00:00:00 UTC 2012
Reduced expression of BTBD10, an Akt activator, leads to motor neuron death.
Cell death and differentiation
Nawa M,Kage-Nakadai E,Aiso S,Okamoto K,Mitani S,Matsuoka M
Wed Aug 01 00:00:00 UTC 2012
Reduced expression of BTBD10, an Akt activator, leads to motor neuron death.
Cell death and differentiation
Nawa M,Kage-Nakadai E,Aiso S,Okamoto K,Mitani S,Matsuoka M
Wed Aug 01 00:00:00 UTC 2012
TMEM106B risk variant is implicated in the pathologic presentation of Alzheimer disease.
Neurology
Rutherford NJ,Carrasquillo MM,Li M,Bisceglio G,Menke J,Josephs KA,Parisi JE,Petersen RC,Graff-Radford NR,Younkin SG,Dickson DW,Rademakers R
Tue Aug 14 00:00:00 UTC 2012
TMEM106B risk variant is implicated in the pathologic presentation of Alzheimer disease.
Neurology
Rutherford NJ,Carrasquillo MM,Li M,Bisceglio G,Menke J,Josephs KA,Parisi JE,Petersen RC,Graff-Radford NR,Younkin SG,Dickson DW,Rademakers R
Tue Aug 14 00:00:00 UTC 2012
Clinical features of SCA36: a novel spinocerebellar ataxia with motor neuron involvement (Asidan).
Neurology
Ikeda Y,Ohta Y,Kobayashi H,Okamoto M,Takamatsu K,Ota T,Manabe Y,Okamoto K,Koizumi A,Abe K
Tue Jul 24 00:00:00 UTC 2012
Clinical features of SCA36: a novel spinocerebellar ataxia with motor neuron involvement (Asidan).
Neurology
Ikeda Y,Ohta Y,Kobayashi H,Okamoto M,Takamatsu K,Ota T,Manabe Y,Okamoto K,Koizumi A,Abe K
Tue Jul 24 00:00:00 UTC 2012
Exome sequencing reveals DNAJB6 mutations in dominantly-inherited myopathy.
Annals of neurology
Harms MB,Sommerville RB,Allred P,Bell S,Ma D,Cooper P,Lopate G,Pestronk A,Weihl CC,Baloh RH
Thu Mar 01 00:00:00 UTC 2012
Exome sequencing reveals DNAJB6 mutations in dominantly-inherited myopathy.
Annals of neurology
Harms MB,Sommerville RB,Allred P,Bell S,Ma D,Cooper P,Lopate G,Pestronk A,Weihl CC,Baloh RH
Thu Mar 01 00:00:00 UTC 2012
Exome sequencing reveals DNAJB6 mutations in dominantly-inherited myopathy.
Annals of neurology
Harms MB,Sommerville RB,Allred P,Bell S,Ma D,Cooper P,Lopate G,Pestronk A,Weihl CC,Baloh RH
Thu Mar 01 00:00:00 UTC 2012
Glucose delays age-dependent proteotoxicity.
Aging cell
Tauffenberger A,Vaccaro A,Aulas A,Vande Velde C,Parker JA
Mon Oct 01 00:00:00 UTC 2012
Glucose delays age-dependent proteotoxicity.
Aging cell
Tauffenberger A,Vaccaro A,Aulas A,Vande Velde C,Parker JA
Mon Oct 01 00:00:00 UTC 2012
Transglutaminase 1 and its regulator tazarotene-induced gene 3 localize to neuronal tau inclusions in tauopathies.
The Journal of pathology
Wilhelmus MM,de Jager M,Rozemuller AJ,Brevé J,Bol JG,Eckert RL,Drukarch B
Sun Jan 01 00:00:00 UTC 2012
Transglutaminase 1 and its regulator tazarotene-induced gene 3 localize to neuronal tau inclusions in tauopathies.
The Journal of pathology
Wilhelmus MM,de Jager M,Rozemuller AJ,Brevé J,Bol JG,Eckert RL,Drukarch B
Sun Jan 01 00:00:00 UTC 2012
Multiple system atrophy-parkinsonism with slow progression and prolonged survival: a diagnostic catch.
Movement disorders : official journal of the Movement Disorder Society
Petrovic IN,Ling H,Asi Y,Ahmed Z,Kukkle PL,Hazrati LN,Lang AE,Revesz T,Holton JL,Lees AJ
Wed Aug 01 00:00:00 UTC 2012
Multiple system atrophy-parkinsonism with slow progression and prolonged survival: a diagnostic catch.
Movement disorders : official journal of the Movement Disorder Society
Petrovic IN,Ling H,Asi Y,Ahmed Z,Kukkle PL,Hazrati LN,Lang AE,Revesz T,Holton JL,Lees AJ
Wed Aug 01 00:00:00 UTC 2012
Association of UBQLN1 mutation with Brown-Vialetto-Van Laere syndrome but not typical ALS.
Neurobiology of disease
González-Pérez P,Lu Y,Chian RJ,Sapp PC,Tanzi RE,Bertram L,McKenna-Yasek D,Gao FB,Brown RH
Sat Dec 01 00:00:00 UTC 2012
Association of UBQLN1 mutation with Brown-Vialetto-Van Laere syndrome but not typical ALS.
Neurobiology of disease
González-Pérez P,Lu Y,Chian RJ,Sapp PC,Tanzi RE,Bertram L,McKenna-Yasek D,Gao FB,Brown RH
Sat Dec 01 00:00:00 UTC 2012
Association of UBQLN1 mutation with Brown-Vialetto-Van Laere syndrome but not typical ALS.
Neurobiology of disease
González-Pérez P,Lu Y,Chian RJ,Sapp PC,Tanzi RE,Bertram L,McKenna-Yasek D,Gao FB,Brown RH
Sat Dec 01 00:00:00 UTC 2012
Association of UBQLN1 mutation with Brown-Vialetto-Van Laere syndrome but not typical ALS.
Neurobiology of disease
González-Pérez P,Lu Y,Chian RJ,Sapp PC,Tanzi RE,Bertram L,McKenna-Yasek D,Gao FB,Brown RH
Sat Dec 01 00:00:00 UTC 2012
Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies.
Neurobiology of disease
Iguchi Y,Katsuno M,Takagi S,Ishigaki S,Niwa J,Hasegawa M,Tanaka F,Sobue G
Thu Mar 01 00:00:00 UTC 2012
Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies.
Neurobiology of disease
Iguchi Y,Katsuno M,Takagi S,Ishigaki S,Niwa J,Hasegawa M,Tanaka F,Sobue G
Thu Mar 01 00:00:00 UTC 2012
Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies.
Neurobiology of disease
Iguchi Y,Katsuno M,Takagi S,Ishigaki S,Niwa J,Hasegawa M,Tanaka F,Sobue G
Thu Mar 01 00:00:00 UTC 2012
Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies.
Neurobiology of disease
Iguchi Y,Katsuno M,Takagi S,Ishigaki S,Niwa J,Hasegawa M,Tanaka F,Sobue G
Thu Mar 01 00:00:00 UTC 2012
ALS-associated ataxin 2 polyQ expansions enhance stress-induced caspase 3 activation and increase TDP-43 pathological modifications.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Hart MP,Gitler AD
Wed Jul 04 00:00:00 UTC 2012
ALS-associated ataxin 2 polyQ expansions enhance stress-induced caspase 3 activation and increase TDP-43 pathological modifications.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Hart MP,Gitler AD
Wed Jul 04 00:00:00 UTC 2012
ALS-associated ataxin 2 polyQ expansions enhance stress-induced caspase 3 activation and increase TDP-43 pathological modifications.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Hart MP,Gitler AD
Wed Jul 04 00:00:00 UTC 2012
ALS-associated ataxin 2 polyQ expansions enhance stress-induced caspase 3 activation and increase TDP-43 pathological modifications.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Hart MP,Gitler AD
Wed Jul 04 00:00:00 UTC 2012
An early onset progressive motor neuron disorder in Scyl1-deficient mice is associated with mislocalization of TDP-43.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Pelletier S,Gingras S,Howell S,Vogel P,Ihle JN
Wed Nov 21 00:00:00 UTC 2012
An early onset progressive motor neuron disorder in Scyl1-deficient mice is associated with mislocalization of TDP-43.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Pelletier S,Gingras S,Howell S,Vogel P,Ihle JN
Wed Nov 21 00:00:00 UTC 2012
An early onset progressive motor neuron disorder in Scyl1-deficient mice is associated with mislocalization of TDP-43.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Pelletier S,Gingras S,Howell S,Vogel P,Ihle JN
Wed Nov 21 00:00:00 UTC 2012
An early onset progressive motor neuron disorder in Scyl1-deficient mice is associated with mislocalization of TDP-43.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Pelletier S,Gingras S,Howell S,Vogel P,Ihle JN
Wed Nov 21 00:00:00 UTC 2012
A quantitative study of the neuropathology of 32 sporadic and familial cases of frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP).
Neuropathology and applied neurobiology
Armstrong RA,Carter D,Cairns NJ
Wed Feb 01 00:00:00 UTC 2012
A quantitative study of the neuropathology of 32 sporadic and familial cases of frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP).
Neuropathology and applied neurobiology
Armstrong RA,Carter D,Cairns NJ
Wed Feb 01 00:00:00 UTC 2012
Cognitive decline typical of frontotemporal lobar degeneration in transgenic mice expressing the 25-kDa C-terminal fragment of TDP-43.
The American journal of pathology
Caccamo A,Majumder S,Oddo S
Sun Jan 01 00:00:00 UTC 2012
Cognitive decline typical of frontotemporal lobar degeneration in transgenic mice expressing the 25-kDa C-terminal fragment of TDP-43.
The American journal of pathology
Caccamo A,Majumder S,Oddo S
Sun Jan 01 00:00:00 UTC 2012
Wild type TDP-43 induces neuro-inflammation and alters APP metabolism in lentiviral gene transfer models.
Experimental neurology
Herman AM,Khandelwal PJ,Rebeck GW,Moussa CE
Tue May 01 00:00:00 UTC 2012
Wild type TDP-43 induces neuro-inflammation and alters APP metabolism in lentiviral gene transfer models.
Experimental neurology
Herman AM,Khandelwal PJ,Rebeck GW,Moussa CE
Tue May 01 00:00:00 UTC 2012
Wild type TDP-43 induces neuro-inflammation and alters APP metabolism in lentiviral gene transfer models.
Experimental neurology
Herman AM,Khandelwal PJ,Rebeck GW,Moussa CE
Tue May 01 00:00:00 UTC 2012
Wild type TDP-43 induces neuro-inflammation and alters APP metabolism in lentiviral gene transfer models.
Experimental neurology
Herman AM,Khandelwal PJ,Rebeck GW,Moussa CE
Tue May 01 00:00:00 UTC 2012
Wild type TDP-43 induces neuro-inflammation and alters APP metabolism in lentiviral gene transfer models.
Experimental neurology
Herman AM,Khandelwal PJ,Rebeck GW,Moussa CE
Tue May 01 00:00:00 UTC 2012
Wild type TDP-43 induces neuro-inflammation and alters APP metabolism in lentiviral gene transfer models.
Experimental neurology
Herman AM,Khandelwal PJ,Rebeck GW,Moussa CE
Tue May 01 00:00:00 UTC 2012
Absence of SOD1 leads to oxidative stress in peripheral nerve and causes a progressive distal motor axonopathy.
Experimental neurology
Fischer LR,Li Y,Asress SA,Jones DP,Glass JD
Sun Jan 01 00:00:00 UTC 2012
Absence of SOD1 leads to oxidative stress in peripheral nerve and causes a progressive distal motor axonopathy.
Experimental neurology
Fischer LR,Li Y,Asress SA,Jones DP,Glass JD
Sun Jan 01 00:00:00 UTC 2012
Asparaginyl endopeptidase cleaves TDP-43 in brain.
Proteomics
Herskowitz JH,Gozal YM,Duong DM,Dammer EB,Gearing M,Ye K,Lah JJ,Peng J,Levey AI,Seyfried NT
Wed Aug 01 00:00:00 UTC 2012
Asparaginyl endopeptidase cleaves TDP-43 in brain.
Proteomics
Herskowitz JH,Gozal YM,Duong DM,Dammer EB,Gearing M,Ye K,Lah JJ,Peng J,Levey AI,Seyfried NT
Wed Aug 01 00:00:00 UTC 2012
Quantitative analysis of the detergent-insoluble brain proteome in frontotemporal lobar degeneration using SILAC internal standards.
Journal of proteome research
Seyfried NT,Gozal YM,Donovan LE,Herskowitz JH,Dammer EB,Xia Q,Ku L,Chang J,Duong DM,Rees HD,Cooper DS,Glass JD,Gearing M,Tansey MG,Lah JJ,Feng Y,Levey AI,Peng J
Fri May 04 00:00:00 UTC 2012
Quantitative analysis of the detergent-insoluble brain proteome in frontotemporal lobar degeneration using SILAC internal standards.
Journal of proteome research
Seyfried NT,Gozal YM,Donovan LE,Herskowitz JH,Dammer EB,Xia Q,Ku L,Chang J,Duong DM,Rees HD,Cooper DS,Glass JD,Gearing M,Tansey MG,Lah JJ,Feng Y,Levey AI,Peng J
Fri May 04 00:00:00 UTC 2012
Quantitative analysis of the detergent-insoluble brain proteome in frontotemporal lobar degeneration using SILAC internal standards.
Journal of proteome research
Seyfried NT,Gozal YM,Donovan LE,Herskowitz JH,Dammer EB,Xia Q,Ku L,Chang J,Duong DM,Rees HD,Cooper DS,Glass JD,Gearing M,Tansey MG,Lah JJ,Feng Y,Levey AI,Peng J
Fri May 04 00:00:00 UTC 2012
Quantitative analysis of the detergent-insoluble brain proteome in frontotemporal lobar degeneration using SILAC internal standards.
Journal of proteome research
Seyfried NT,Gozal YM,Donovan LE,Herskowitz JH,Dammer EB,Xia Q,Ku L,Chang J,Duong DM,Rees HD,Cooper DS,Glass JD,Gearing M,Tansey MG,Lah JJ,Feng Y,Levey AI,Peng J
Fri May 04 00:00:00 UTC 2012
Alteration in cell cycle-related proteins in lymphoblasts from carriers of the c.709-1G>A PGRN mutation associated with FTLD-TDP dementia.
Neurobiology of aging
Alquezar C,Esteras N,Bartolomé F,Merino JJ,Alzualde A,López de Munain A,Martín-Requero Á
Wed Feb 01 00:00:00 UTC 2012
Alteration in cell cycle-related proteins in lymphoblasts from carriers of the c.709-1G>A PGRN mutation associated with FTLD-TDP dementia.
Neurobiology of aging
Alquezar C,Esteras N,Bartolomé F,Merino JJ,Alzualde A,López de Munain A,Martín-Requero Á
Wed Feb 01 00:00:00 UTC 2012
Alteration in cell cycle-related proteins in lymphoblasts from carriers of the c.709-1G>A PGRN mutation associated with FTLD-TDP dementia.
Neurobiology of aging
Alquezar C,Esteras N,Bartolomé F,Merino JJ,Alzualde A,López de Munain A,Martín-Requero Á
Wed Feb 01 00:00:00 UTC 2012
Alteration in cell cycle-related proteins in lymphoblasts from carriers of the c.709-1G>A PGRN mutation associated with FTLD-TDP dementia.
Neurobiology of aging
Alquezar C,Esteras N,Bartolomé F,Merino JJ,Alzualde A,López de Munain A,Martín-Requero Á
Wed Feb 01 00:00:00 UTC 2012
UBQLN2/ubiquilin 2 mutation and pathology in familial amyotrophic lateral sclerosis.
Neurobiology of aging
Williams KL,Warraich ST,Yang S,Solski JA,Fernando R,Rouleau GA,Nicholson GA,Blair IP
Mon Oct 01 00:00:00 UTC 2012
UBQLN2/ubiquilin 2 mutation and pathology in familial amyotrophic lateral sclerosis.
Neurobiology of aging
Williams KL,Warraich ST,Yang S,Solski JA,Fernando R,Rouleau GA,Nicholson GA,Blair IP
Mon Oct 01 00:00:00 UTC 2012
Genetic association of CR1 with Alzheimer's disease: a tentative disease mechanism.
Neurobiology of aging
Hazrati LN,Van Cauwenberghe C,Brooks PL,Brouwers N,Ghani M,Sato C,Cruts M,Sleegers K,St George-Hyslop P,Van Broeckhoven C,Rogaeva E
Sat Dec 01 00:00:00 UTC 2012
Genetic association of CR1 with Alzheimer's disease: a tentative disease mechanism.
Neurobiology of aging
Hazrati LN,Van Cauwenberghe C,Brooks PL,Brouwers N,Ghani M,Sato C,Cruts M,Sleegers K,St George-Hyslop P,Van Broeckhoven C,Rogaeva E
Sat Dec 01 00:00:00 UTC 2012
High-content RNAi screening identifies the Type 1 inositol triphosphate receptor as a modifier of TDP-43 localization and neurotoxicity.
Human molecular genetics
Kim SH,Zhan L,Hanson KA,Tibbetts RS
Thu Nov 15 00:00:00 UTC 2012
High-content RNAi screening identifies the Type 1 inositol triphosphate receptor as a modifier of TDP-43 localization and neurotoxicity.
Human molecular genetics
Kim SH,Zhan L,Hanson KA,Tibbetts RS
Thu Nov 15 00:00:00 UTC 2012
High-content RNAi screening identifies the Type 1 inositol triphosphate receptor as a modifier of TDP-43 localization and neurotoxicity.
Human molecular genetics
Kim SH,Zhan L,Hanson KA,Tibbetts RS
Thu Nov 15 00:00:00 UTC 2012
High-content RNAi screening identifies the Type 1 inositol triphosphate receptor as a modifier of TDP-43 localization and neurotoxicity.
Human molecular genetics
Kim SH,Zhan L,Hanson KA,Tibbetts RS
Thu Nov 15 00:00:00 UTC 2012
Entorhinal cortical neurons are the primary targets of FUS mislocalization and ubiquitin aggregation in FUS transgenic rats.
Human molecular genetics
Huang C,Tong J,Bi F,Wu Q,Huang B,Zhou H,Xia XG
Thu Nov 01 00:00:00 UTC 2012
Entorhinal cortical neurons are the primary targets of FUS mislocalization and ubiquitin aggregation in FUS transgenic rats.
Human molecular genetics
Huang C,Tong J,Bi F,Wu Q,Huang B,Zhou H,Xia XG
Thu Nov 01 00:00:00 UTC 2012
A role for SMN exon 7 splicing in the selective vulnerability of motor neurons in spinal muscular atrophy.
Molecular and cellular biology
Ruggiu M,McGovern VL,Lotti F,Saieva L,Li DK,Kariya S,Monani UR,Burghes AH,Pellizzoni L
Sun Jan 01 00:00:00 UTC 2012
A role for SMN exon 7 splicing in the selective vulnerability of motor neurons in spinal muscular atrophy.
Molecular and cellular biology
Ruggiu M,McGovern VL,Lotti F,Saieva L,Li DK,Kariya S,Monani UR,Burghes AH,Pellizzoni L
Sun Jan 01 00:00:00 UTC 2012
Tunicamycin produces TDP-43 cytoplasmic inclusions in cultured brain organotypic slices.
Journal of the neurological sciences
Leggett C,McGehee DS,Mastrianni J,Yang W,Bai T,Brorson JR
Fri Jun 15 00:00:00 UTC 2012
Tunicamycin produces TDP-43 cytoplasmic inclusions in cultured brain organotypic slices.
Journal of the neurological sciences
Leggett C,McGehee DS,Mastrianni J,Yang W,Bai T,Brorson JR
Fri Jun 15 00:00:00 UTC 2012
Comparison of phosphorylated TDP-43-positive inclusions in oculomotor neurons in patients with non-ALS and ALS disorders.
Journal of the neurological sciences
Mizuno Y,Fujita Y,Takatama M,Okamoto K
Sun Apr 15 00:00:00 UTC 2012
Comparison of phosphorylated TDP-43-positive inclusions in oculomotor neurons in patients with non-ALS and ALS disorders.
Journal of the neurological sciences
Mizuno Y,Fujita Y,Takatama M,Okamoto K
Sun Apr 15 00:00:00 UTC 2012
Familial ALS with FUS P525L mutation: two Japanese sisters with multiple systems involvement.
Journal of the neurological sciences
Mochizuki Y,Isozaki E,Takao M,Hashimoto T,Shibuya M,Arai M,Hosokawa M,Kawata A,Oyanagi K,Mihara B,Mizutani T
Sat Dec 15 00:00:00 UTC 2012
Familial ALS with FUS P525L mutation: two Japanese sisters with multiple systems involvement.
Journal of the neurological sciences
Mochizuki Y,Isozaki E,Takao M,Hashimoto T,Shibuya M,Arai M,Hosokawa M,Kawata A,Oyanagi K,Mihara B,Mizutani T
Sat Dec 15 00:00:00 UTC 2012
First neuropathological description of a patient with Parkinson's disease and LRRK2 p.N1437H mutation.
Parkinsonism & related disorders
Puschmann A,Englund E,Ross OA,Vilariño-Güell C,Lincoln SJ,Kachergus JM,Cobb SA,Törnqvist AL,Rehncrona S,Widner H,Wszolek ZK,Farrer MJ,Nilsson C
Tue May 01 00:00:00 UTC 2012
First neuropathological description of a patient with Parkinson's disease and LRRK2 p.N1437H mutation.
Parkinsonism & related disorders
Puschmann A,Englund E,Ross OA,Vilariño-Güell C,Lincoln SJ,Kachergus JM,Cobb SA,Törnqvist AL,Rehncrona S,Widner H,Wszolek ZK,Farrer MJ,Nilsson C
Tue May 01 00:00:00 UTC 2012
Endogenous TDP-43 localized to stress granules can subsequently form protein aggregates.
Neurochemistry international
Parker SJ,Meyerowitz J,James JL,Liddell JR,Crouch PJ,Kanninen KM,White AR
Thu Mar 01 00:00:00 UTC 2012
Endogenous TDP-43 localized to stress granules can subsequently form protein aggregates.
Neurochemistry international
Parker SJ,Meyerowitz J,James JL,Liddell JR,Crouch PJ,Kanninen KM,White AR
Thu Mar 01 00:00:00 UTC 2012
Clinical, neuropathological, and genetic characteristics of the novel IVS9+1delG GRN mutation in a patient with frontotemporal dementia.
Journal of Alzheimer's disease : JAD
Taipa R,Tuna A,Damásio J,Pinto PS,Cavaco S,Pereira S,Milterberger-Miltenyi G,Galimberti D,Melo-Pires M
Mon Sep 10 00:00:00 UTC 2012
Clinical, neuropathological, and genetic characteristics of the novel IVS9+1delG GRN mutation in a patient with frontotemporal dementia.
Journal of Alzheimer's disease : JAD
Taipa R,Tuna A,Damásio J,Pinto PS,Cavaco S,Pereira S,Milterberger-Miltenyi G,Galimberti D,Melo-Pires M
Mon Sep 10 00:00:00 UTC 2012
Mitochondrial dysfunction in human TDP-43 transfected NSC34 cell lines and the protective effect of dimethoxy curcumin.
Brain research bulletin
Lu J,Duan W,Guo Y,Jiang H,Li Z,Huang J,Hong K,Li C
Sat Dec 01 00:00:00 UTC 2012
Mitochondrial dysfunction in human TDP-43 transfected NSC34 cell lines and the protective effect of dimethoxy curcumin.
Brain research bulletin
Lu J,Duan W,Guo Y,Jiang H,Li Z,Huang J,Hong K,Li C
Sat Dec 01 00:00:00 UTC 2012
Mitochondrial dysfunction in human TDP-43 transfected NSC34 cell lines and the protective effect of dimethoxy curcumin.
Brain research bulletin
Lu J,Duan W,Guo Y,Jiang H,Li Z,Huang J,Hong K,Li C
Sat Dec 01 00:00:00 UTC 2012
Role of selected mutations in the Q/N rich region of TDP-43 in EGFP-12xQ/N-induced aggregate formation.
Brain research
Budini M,Romano V,Avendaño-Vázquez SE,Bembich S,Buratti E,Baralle FE
Tue Jun 26 00:00:00 UTC 2012
Role of selected mutations in the Q/N rich region of TDP-43 in EGFP-12xQ/N-induced aggregate formation.
Brain research
Budini M,Romano V,Avendaño-Vázquez SE,Bembich S,Buratti E,Baralle FE
Tue Jun 26 00:00:00 UTC 2012
Role of selected mutations in the Q/N rich region of TDP-43 in EGFP-12xQ/N-induced aggregate formation.
Brain research
Budini M,Romano V,Avendaño-Vázquez SE,Bembich S,Buratti E,Baralle FE
Tue Jun 26 00:00:00 UTC 2012
Role of selected mutations in the Q/N rich region of TDP-43 in EGFP-12xQ/N-induced aggregate formation.
Brain research
Budini M,Romano V,Avendaño-Vázquez SE,Bembich S,Buratti E,Baralle FE
Tue Jun 26 00:00:00 UTC 2012
HO-1 induction in motor cortex and intestinal dysfunction in TDP-43 A315T transgenic mice.
Brain research
Guo Y,Wang Q,Zhang K,An T,Shi P,Li Z,Duan W,Li C
Fri Jun 15 00:00:00 UTC 2012
HO-1 induction in motor cortex and intestinal dysfunction in TDP-43 A315T transgenic mice.
Brain research
Guo Y,Wang Q,Zhang K,An T,Shi P,Li Z,Duan W,Li C
Fri Jun 15 00:00:00 UTC 2012
Rodent models of TDP-43: recent advances.
Brain research
Tsao W,Jeong YH,Lin S,Ling J,Price DL,Chiang PM,Wong PC
Tue Jun 26 00:00:00 UTC 2012
Rodent models of TDP-43: recent advances.
Brain research
Tsao W,Jeong YH,Lin S,Ling J,Price DL,Chiang PM,Wong PC
Tue Jun 26 00:00:00 UTC 2012
Prevalence, laterality, and comorbidity of hippocampal sclerosis in an autopsy sample.
Brain and behavior
Zarow C,Weiner MW,Ellis WG,Chui HC
Sun Jul 01 00:00:00 UTC 2012
Prevalence, laterality, and comorbidity of hippocampal sclerosis in an autopsy sample.
Brain and behavior
Zarow C,Weiner MW,Ellis WG,Chui HC
Sun Jul 01 00:00:00 UTC 2012
Epitope mapping of antibodies against TDP-43 and detection of protease-resistant fragments of pathological TDP-43 in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
Biochemical and biophysical research communications
Tsuji H,Nonaka T,Yamashita M,Masuda-Suzukake M,Kametani F,Akiyama H,Mann DM,Tamaoka A,Hasegawa M
Fri Jan 06 00:00:00 UTC 2012
Epitope mapping of antibodies against TDP-43 and detection of protease-resistant fragments of pathological TDP-43 in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
Biochemical and biophysical research communications
Tsuji H,Nonaka T,Yamashita M,Masuda-Suzukake M,Kametani F,Akiyama H,Mann DM,Tamaoka A,Hasegawa M
Fri Jan 06 00:00:00 UTC 2012
Endosomal sorting related protein CHMP2B is localized in Lewy bodies and glial cytoplasmic inclusions in α-synucleinopathy.
Neuroscience letters
Tanikawa S,Mori F,Tanji K,Kakita A,Takahashi H,Wakabayashi K
Wed Oct 03 00:00:00 UTC 2012
Endosomal sorting related protein CHMP2B is localized in Lewy bodies and glial cytoplasmic inclusions in α-synucleinopathy.
Neuroscience letters
Tanikawa S,Mori F,Tanji K,Kakita A,Takahashi H,Wakabayashi K
Wed Oct 03 00:00:00 UTC 2012
FUS/TLS-immunoreactive neuronal and glial cell inclusions increase with disease duration in familial amyotrophic lateral sclerosis with an R521C FUS/TLS mutation.
Journal of neuropathology and experimental neurology
Suzuki N,Kato S,Kato M,Warita H,Mizuno H,Kato M,Shimakura N,Akiyama H,Kobayashi Z,Konno H,Aoki M
Sat Sep 01 00:00:00 UTC 2012
FUS/TLS-immunoreactive neuronal and glial cell inclusions increase with disease duration in familial amyotrophic lateral sclerosis with an R521C FUS/TLS mutation.
Journal of neuropathology and experimental neurology
Suzuki N,Kato S,Kato M,Warita H,Mizuno H,Kato M,Shimakura N,Akiyama H,Kobayashi Z,Konno H,Aoki M
Sat Sep 01 00:00:00 UTC 2012
The abnormal processing of TDP-43 is not an upstream event of reduced ADAR2 activity in ALS motor neurons.
Neuroscience research
Yamashita T,Hideyama T,Teramoto S,Kwak S
Fri Jun 01 00:00:00 UTC 2012
The abnormal processing of TDP-43 is not an upstream event of reduced ADAR2 activity in ALS motor neurons.
Neuroscience research
Yamashita T,Hideyama T,Teramoto S,Kwak S
Fri Jun 01 00:00:00 UTC 2012
The abnormal processing of TDP-43 is not an upstream event of reduced ADAR2 activity in ALS motor neurons.
Neuroscience research
Yamashita T,Hideyama T,Teramoto S,Kwak S
Fri Jun 01 00:00:00 UTC 2012
Differential expression of TAR DNA-binding protein (TDP-43) in the central nervous system of horses afflicted with equine motor neuron disease (EMND): a preliminary study of a potential pathologic marker.
Veterinary research communications
El-Assaad I,Di Bari JA,Yasuda K,Divers TJ,Summers BA,de Lahunta A,Mohammed H
Sat Dec 01 00:00:00 UTC 2012
Differential expression of TAR DNA-binding protein (TDP-43) in the central nervous system of horses afflicted with equine motor neuron disease (EMND): a preliminary study of a potential pathologic marker.
Veterinary research communications
El-Assaad I,Di Bari JA,Yasuda K,Divers TJ,Summers BA,de Lahunta A,Mohammed H
Sat Dec 01 00:00:00 UTC 2012
Differential expression of TAR DNA-binding protein (TDP-43) in the central nervous system of horses afflicted with equine motor neuron disease (EMND): a preliminary study of a potential pathologic marker.
Veterinary research communications
El-Assaad I,Di Bari JA,Yasuda K,Divers TJ,Summers BA,de Lahunta A,Mohammed H
Sat Dec 01 00:00:00 UTC 2012
Right temporal variant frontotemporal dementia with motor neuron disease.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Coon EA,Whitwell JL,Parisi JE,Dickson DW,Josephs KA
Sun Jan 01 00:00:00 UTC 2012
Right temporal variant frontotemporal dementia with motor neuron disease.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Coon EA,Whitwell JL,Parisi JE,Dickson DW,Josephs KA
Sun Jan 01 00:00:00 UTC 2012
Unusual clinical presentation and neuropathology in two subjects with fused-in sarcoma (FUS) positive inclusions.
Neuropathology : official journal of the Japanese Society of Neuropathology
Hartikainen PH,Pikkarainen M,Hänninen T,Soininen H,Alafuzoff I
Wed Feb 01 00:00:00 UTC 2012
Unusual clinical presentation and neuropathology in two subjects with fused-in sarcoma (FUS) positive inclusions.
Neuropathology : official journal of the Japanese Society of Neuropathology
Hartikainen PH,Pikkarainen M,Hänninen T,Soininen H,Alafuzoff I
Wed Feb 01 00:00:00 UTC 2012
Progressive nonfluent aphasia: a rare clinical subtype of FTLD-TDP in Japan.
Neuropathology : official journal of the Japanese Society of Neuropathology
Aoki N,Tsuchiya K,Kobayashi Z,Arai T,Togo T,Miyazaki H,Kondo H,Ishizu H,Uchikado H,Katsuse O,Hirayasu Y,Akiyama H
Fri Jun 01 00:00:00 UTC 2012
Progressive nonfluent aphasia: a rare clinical subtype of FTLD-TDP in Japan.
Neuropathology : official journal of the Japanese Society of Neuropathology
Aoki N,Tsuchiya K,Kobayashi Z,Arai T,Togo T,Miyazaki H,Kondo H,Ishizu H,Uchikado H,Katsuse O,Hirayasu Y,Akiyama H
Fri Jun 01 00:00:00 UTC 2012
Abnormal tau deposition in neurons, but not in glial cells in the cerebral tissue surrounding arteriovenous malformation.
Neuropathology : official journal of the Japanese Society of Neuropathology
Kon T,Mori F,Tanji K,Miki Y,Tomiyama M,Baba M,Umehara Y,Kurotaki H,Wakabayashi K
Fri Jun 01 00:00:00 UTC 2012
Abnormal tau deposition in neurons, but not in glial cells in the cerebral tissue surrounding arteriovenous malformation.
Neuropathology : official journal of the Japanese Society of Neuropathology
Kon T,Mori F,Tanji K,Miki Y,Tomiyama M,Baba M,Umehara Y,Kurotaki H,Wakabayashi K
Fri Jun 01 00:00:00 UTC 2012
An MND/ALS phenotype associated with C9orf72 repeat expansion: abundant p62-positive, TDP-43-negative inclusions in cerebral cortex, hippocampus and cerebellum but without associated cognitive decline.
Neuropathology : official journal of the Japanese Society of Neuropathology
Troakes C,Maekawa S,Wijesekera L,Rogelj B,Siklós L,Bell C,Smith B,Newhouse S,Vance C,Johnson L,Hortobágyi T,Shatunov A,Al-Chalabi A,Leigh N,Shaw CE,King A,Al-Sarraj S
Mon Oct 01 00:00:00 UTC 2012
An MND/ALS phenotype associated with C9orf72 repeat expansion: abundant p62-positive, TDP-43-negative inclusions in cerebral cortex, hippocampus and cerebellum but without associated cognitive decline.
Neuropathology : official journal of the Japanese Society of Neuropathology
Troakes C,Maekawa S,Wijesekera L,Rogelj B,Siklós L,Bell C,Smith B,Newhouse S,Vance C,Johnson L,Hortobágyi T,Shatunov A,Al-Chalabi A,Leigh N,Shaw CE,King A,Al-Sarraj S
Mon Oct 01 00:00:00 UTC 2012
Neuropathology in classical and variant ataxia-telangiectasia.
Neuropathology : official journal of the Japanese Society of Neuropathology
Verhagen MM,Martin JJ,van Deuren M,Ceuterick-de Groote C,Weemaes CM,Kremer BH,Taylor MA,Willemsen MA,Lammens M
Fri Jun 01 00:00:00 UTC 2012
Neuropathology in classical and variant ataxia-telangiectasia.
Neuropathology : official journal of the Japanese Society of Neuropathology
Verhagen MM,Martin JJ,van Deuren M,Ceuterick-de Groote C,Weemaes CM,Kremer BH,Taylor MA,Willemsen MA,Lammens M
Fri Jun 01 00:00:00 UTC 2012
Benign hereditary chorea 2: pathological findings in an autopsy case.
Neuropathology : official journal of the Japanese Society of Neuropathology
Yoshida Y,Nunomura J,Shimohata T,Nanjo H,Miyata H
Mon Oct 01 00:00:00 UTC 2012
Benign hereditary chorea 2: pathological findings in an autopsy case.
Neuropathology : official journal of the Japanese Society of Neuropathology
Yoshida Y,Nunomura J,Shimohata T,Nanjo H,Miyata H
Mon Oct 01 00:00:00 UTC 2012
Primary lateral sclerosis: upper-motor-predominant amyotrophic lateral sclerosis with frontotemporal lobar degeneration--immunohistochemical and biochemical analyses of TDP-43.
Neuropathology : official journal of the Japanese Society of Neuropathology
Kosaka T,Fu YJ,Shiga A,Ishidaira H,Tan CF,Tani T,Koike R,Onodera O,Nishizawa M,Kakita A,Takahashi H
Wed Aug 01 00:00:00 UTC 2012
Primary lateral sclerosis: upper-motor-predominant amyotrophic lateral sclerosis with frontotemporal lobar degeneration--immunohistochemical and biochemical analyses of TDP-43.
Neuropathology : official journal of the Japanese Society of Neuropathology
Kosaka T,Fu YJ,Shiga A,Ishidaira H,Tan CF,Tani T,Koike R,Onodera O,Nishizawa M,Kakita A,Takahashi H
Wed Aug 01 00:00:00 UTC 2012
Primary lateral sclerosis: upper-motor-predominant amyotrophic lateral sclerosis with frontotemporal lobar degeneration--immunohistochemical and biochemical analyses of TDP-43.
Neuropathology : official journal of the Japanese Society of Neuropathology
Kosaka T,Fu YJ,Shiga A,Ishidaira H,Tan CF,Tani T,Koike R,Onodera O,Nishizawa M,Kakita A,Takahashi H
Wed Aug 01 00:00:00 UTC 2012
Primary lateral sclerosis: upper-motor-predominant amyotrophic lateral sclerosis with frontotemporal lobar degeneration--immunohistochemical and biochemical analyses of TDP-43.
Neuropathology : official journal of the Japanese Society of Neuropathology
Kosaka T,Fu YJ,Shiga A,Ishidaira H,Tan CF,Tani T,Koike R,Onodera O,Nishizawa M,Kakita A,Takahashi H
Wed Aug 01 00:00:00 UTC 2012
Essential tremor with ubiquitinated intranuclear inclusions and cerebellar degeneration.
Clinical neuropathology
Louis ED,Mazzoni P,Ma KJ,Moskowitz CB,Lawton A,Garber A,Vonsattel JP
Thu Jul 19 00:00:00 UTC 2012
Essential tremor with ubiquitinated intranuclear inclusions and cerebellar degeneration.
Clinical neuropathology
Louis ED,Mazzoni P,Ma KJ,Moskowitz CB,Lawton A,Garber A,Vonsattel JP
Thu Jul 19 00:00:00 UTC 2012
TDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegans.
PLoS genetics
Vaccaro A,Tauffenberger A,Ash PE,Carlomagno Y,Petrucelli L,Parker JA
Sun Jul 01 00:00:00 UTC 2012
TDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegans.
PLoS genetics
Vaccaro A,Tauffenberger A,Ash PE,Carlomagno Y,Petrucelli L,Parker JA
Sun Jul 01 00:00:00 UTC 2012
Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects.
Cell reports
Almeida S,Zhang Z,Coppola G,Mao W,Futai K,Karydas A,Geschwind MD,Tartaglia MC,Gao F,Gianni D,Sena-Esteves M,Geschwind DH,Miller BL,Farese RV,Gao FB
Thu Oct 25 00:00:00 UTC 2012
Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects.
Cell reports
Almeida S,Zhang Z,Coppola G,Mao W,Futai K,Karydas A,Geschwind MD,Tartaglia MC,Gao F,Gianni D,Sena-Esteves M,Geschwind DH,Miller BL,Farese RV,Gao FB
Thu Oct 25 00:00:00 UTC 2012
Co-occurrence of TDP-43 mislocalization with reduced activity of an RNA editing enzyme, ADAR2, in aged mouse motor neurons.
PloS one
Hideyama T,Teramoto S,Hachiga K,Yamashita T,Kwak S
Wed Jan 16 00:00:00 UTC 2013
Co-occurrence of TDP-43 mislocalization with reduced activity of an RNA editing enzyme, ADAR2, in aged mouse motor neurons.
PloS one
Hideyama T,Teramoto S,Hachiga K,Yamashita T,Kwak S
Wed Jan 16 00:00:00 UTC 2013
Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes.
PloS one
Parker SJ,Meyerowitz J,James JL,Liddell JR,Nonaka T,Hasegawa M,Kanninen KM,Lim S,Paterson BM,Donnelly PS,Crouch PJ,White AR
Thu Jan 10 00:00:00 UTC 2013
Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes.
PloS one
Parker SJ,Meyerowitz J,James JL,Liddell JR,Nonaka T,Hasegawa M,Kanninen KM,Lim S,Paterson BM,Donnelly PS,Crouch PJ,White AR
Thu Jan 10 00:00:00 UTC 2013
Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes.
PloS one
Parker SJ,Meyerowitz J,James JL,Liddell JR,Nonaka T,Hasegawa M,Kanninen KM,Lim S,Paterson BM,Donnelly PS,Crouch PJ,White AR
Thu Jan 10 00:00:00 UTC 2013
Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes.
PloS one
Parker SJ,Meyerowitz J,James JL,Liddell JR,Nonaka T,Hasegawa M,Kanninen KM,Lim S,Paterson BM,Donnelly PS,Crouch PJ,White AR
Thu Jan 10 00:00:00 UTC 2013
TDP-43 identified from a genome wide RNAi screen for SOD1 regulators.
PloS one
Somalinga BR,Day CE,Wei S,Roth MG,Thomas PJ
Mon Sep 17 00:00:00 UTC 2012
TDP-43 identified from a genome wide RNAi screen for SOD1 regulators.
PloS one
Somalinga BR,Day CE,Wei S,Roth MG,Thomas PJ
Mon Sep 17 00:00:00 UTC 2012
Caenorhabditis elegans RNA-processing protein TDP-1 regulates protein homeostasis and life span.
The Journal of biological chemistry
Zhang T,Hwang HY,Hao H,Talbot C,Wang J
Fri Mar 09 00:00:00 UTC 2012
Caenorhabditis elegans RNA-processing protein TDP-1 regulates protein homeostasis and life span.
The Journal of biological chemistry
Zhang T,Hwang HY,Hao H,Talbot C,Wang J
Fri Mar 09 00:00:00 UTC 2012
A novel TARDBP insertion/deletion mutation in the flail arm variant of amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
Solski JA,Yang S,Nicholson GA,Luquin N,Williams KL,Fernando R,Pamphlett R,Blair IP
Sat Sep 01 00:00:00 UTC 2012
A novel TARDBP insertion/deletion mutation in the flail arm variant of amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
Solski JA,Yang S,Nicholson GA,Luquin N,Williams KL,Fernando R,Pamphlett R,Blair IP
Sat Sep 01 00:00:00 UTC 2012
Supranuclear ophthalmoparesis and vacuolar degeneration of the cerebral white matter in amyotrophic lateral sclerosis: a clinicopathological study.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
Takeda T,Uchihara T,Mochizuki Y,Ishihara A,Nakamura A,Sasaki S,Uchiyama S,Iwata M,Mizutani T
Sun Jan 01 00:00:00 UTC 2012
Supranuclear ophthalmoparesis and vacuolar degeneration of the cerebral white matter in amyotrophic lateral sclerosis: a clinicopathological study.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
Takeda T,Uchihara T,Mochizuki Y,Ishihara A,Nakamura A,Sasaki S,Uchiyama S,Iwata M,Mizutani T
Sun Jan 01 00:00:00 UTC 2012
Requirements for stress granule recruitment of fused in sarcoma (FUS) and TAR DNA-binding protein of 43 kDa (TDP-43).
The Journal of biological chemistry
Bentmann E,Neumann M,Tahirovic S,Rodde R,Dormann D,Haass C
Fri Jun 29 00:00:00 UTC 2012
Requirements for stress granule recruitment of fused in sarcoma (FUS) and TAR DNA-binding protein of 43 kDa (TDP-43).
The Journal of biological chemistry
Bentmann E,Neumann M,Tahirovic S,Rodde R,Dormann D,Haass C
Fri Jun 29 00:00:00 UTC 2012
Requirements for stress granule recruitment of fused in sarcoma (FUS) and TAR DNA-binding protein of 43 kDa (TDP-43).
The Journal of biological chemistry
Bentmann E,Neumann M,Tahirovic S,Rodde R,Dormann D,Haass C
Fri Jun 29 00:00:00 UTC 2012
Requirements for stress granule recruitment of fused in sarcoma (FUS) and TAR DNA-binding protein of 43 kDa (TDP-43).
The Journal of biological chemistry
Bentmann E,Neumann M,Tahirovic S,Rodde R,Dormann D,Haass C
Fri Jun 29 00:00:00 UTC 2012
Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis.
Molecular neurodegeneration
Verbeeck C,Deng Q,Dejesus-Hernandez M,Taylor G,Ceballos-Diaz C,Kocerha J,Golde T,Das P,Rademakers R,Dickson DW,Kukar T
Wed Oct 10 00:00:00 UTC 2012
Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis.
Molecular neurodegeneration
Verbeeck C,Deng Q,Dejesus-Hernandez M,Taylor G,Ceballos-Diaz C,Kocerha J,Golde T,Das P,Rademakers R,Dickson DW,Kukar T
Wed Oct 10 00:00:00 UTC 2012
Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP.
Molecular neurodegeneration
Aulas A,Stabile S,Vande Velde C
Wed Oct 24 00:00:00 UTC 2012
Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP.
Molecular neurodegeneration
Aulas A,Stabile S,Vande Velde C
Wed Oct 24 00:00:00 UTC 2012
Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP.
Molecular neurodegeneration
Aulas A,Stabile S,Vande Velde C
Wed Oct 24 00:00:00 UTC 2012
Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP.
Molecular neurodegeneration
Aulas A,Stabile S,Vande Velde C
Wed Oct 24 00:00:00 UTC 2012
Methylene blue protects against TDP-43 and FUS neuronal toxicity in C. elegans and D. rerio.
PloS one
Vaccaro A,Patten SA,Ciura S,Maios C,Therrien M,Drapeau P,Kabashi E,Parker JA
Thu Jan 10 00:00:00 UTC 2013
Methylene blue protects against TDP-43 and FUS neuronal toxicity in C. elegans and D. rerio.
PloS one
Vaccaro A,Patten SA,Ciura S,Maios C,Therrien M,Drapeau P,Kabashi E,Parker JA
Thu Jan 10 00:00:00 UTC 2013
Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice.
The Journal of biological chemistry
Wu LS,Cheng WC,Shen CK
Fri Aug 10 00:00:00 UTC 2012
Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice.
The Journal of biological chemistry
Wu LS,Cheng WC,Shen CK
Fri Aug 10 00:00:00 UTC 2012
Lack of miRNA Misregulation at Early Pathological Stages in Drosophila Neurodegenerative Disease Models.
Frontiers in genetics
Reinhardt A,Feuillette S,Cassar M,Callens C,Thomassin H,Birman S,Lecourtois M,Antoniewski C,Tricoire H
Fri Nov 02 00:00:00 UTC 2012
Lack of miRNA Misregulation at Early Pathological Stages in Drosophila Neurodegenerative Disease Models.
Frontiers in genetics
Reinhardt A,Feuillette S,Cassar M,Callens C,Thomassin H,Birman S,Lecourtois M,Antoniewski C,Tricoire H
Fri Nov 02 00:00:00 UTC 2012
Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain.
Scientific reports
Rogelj B,Easton LE,Bogu GK,Stanton LW,Rot G,Curk T,Zupan B,Sugimoto Y,Modic M,Haberman N,Tollervey J,Fujii R,Takumi T,Shaw CE,Ule J
Fri Mar 22 00:00:00 UTC 2013
Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain.
Scientific reports
Rogelj B,Easton LE,Bogu GK,Stanton LW,Rot G,Curk T,Zupan B,Sugimoto Y,Modic M,Haberman N,Tollervey J,Fujii R,Takumi T,Shaw CE,Ule J
Fri Mar 22 00:00:00 UTC 2013
FUS-SMN protein interactions link the motor neuron diseases ALS and SMA.
Cell reports
Yamazaki T,Chen S,Yu Y,Yan B,Haertlein TC,Carrasco MA,Tapia JC,Zhai B,Das R,Lalancette-Hebert M,Sharma A,Chandran S,Sullivan G,Nishimura AL,Shaw CE,Gygi SP,Shneider NA,Maniatis T,Reed R
Thu Oct 25 00:00:00 UTC 2012
FUS-SMN protein interactions link the motor neuron diseases ALS and SMA.
Cell reports
Yamazaki T,Chen S,Yu Y,Yan B,Haertlein TC,Carrasco MA,Tapia JC,Zhai B,Das R,Lalancette-Hebert M,Sharma A,Chandran S,Sullivan G,Nishimura AL,Shaw CE,Gygi SP,Shneider NA,Maniatis T,Reed R
Thu Oct 25 00:00:00 UTC 2012
FUS-SMN protein interactions link the motor neuron diseases ALS and SMA.
Cell reports
Yamazaki T,Chen S,Yu Y,Yan B,Haertlein TC,Carrasco MA,Tapia JC,Zhai B,Das R,Lalancette-Hebert M,Sharma A,Chandran S,Sullivan G,Nishimura AL,Shaw CE,Gygi SP,Shneider NA,Maniatis T,Reed R
Thu Oct 25 00:00:00 UTC 2012
FUS-SMN protein interactions link the motor neuron diseases ALS and SMA.
Cell reports
Yamazaki T,Chen S,Yu Y,Yan B,Haertlein TC,Carrasco MA,Tapia JC,Zhai B,Das R,Lalancette-Hebert M,Sharma A,Chandran S,Sullivan G,Nishimura AL,Shaw CE,Gygi SP,Shneider NA,Maniatis T,Reed R
Thu Oct 25 00:00:00 UTC 2012
FUS-SMN protein interactions link the motor neuron diseases ALS and SMA.
Cell reports
Yamazaki T,Chen S,Yu Y,Yan B,Haertlein TC,Carrasco MA,Tapia JC,Zhai B,Das R,Lalancette-Hebert M,Sharma A,Chandran S,Sullivan G,Nishimura AL,Shaw CE,Gygi SP,Shneider NA,Maniatis T,Reed R
Thu Oct 25 00:00:00 UTC 2012
FUS-SMN protein interactions link the motor neuron diseases ALS and SMA.
Cell reports
Yamazaki T,Chen S,Yu Y,Yan B,Haertlein TC,Carrasco MA,Tapia JC,Zhai B,Das R,Lalancette-Hebert M,Sharma A,Chandran S,Sullivan G,Nishimura AL,Shaw CE,Gygi SP,Shneider NA,Maniatis T,Reed R
Thu Oct 25 00:00:00 UTC 2012
TDP-43 plasma levels are higher in amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
Verstraete E,Kuiperij HB,van Blitterswijk MM,Veldink JH,Schelhaas HJ,van den Berg LH,Verbeek MM
Sat Sep 01 00:00:00 UTC 2012
TDP-43 plasma levels are higher in amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
Verstraete E,Kuiperij HB,van Blitterswijk MM,Veldink JH,Schelhaas HJ,van den Berg LH,Verbeek MM
Sat Sep 01 00:00:00 UTC 2012
Mutant TDP-43 and FUS cause age-dependent paralysis and neurodegeneration in C. elegans.
PloS one
Vaccaro A,Tauffenberger A,Aggad D,Rouleau G,Drapeau P,Parker JA
Fri Jun 29 00:00:00 UTC 2012
Mutant TDP-43 and FUS cause age-dependent paralysis and neurodegeneration in C. elegans.
PloS one
Vaccaro A,Tauffenberger A,Aggad D,Rouleau G,Drapeau P,Parker JA
Fri Jun 29 00:00:00 UTC 2012
Mutant TDP-43 and FUS cause age-dependent paralysis and neurodegeneration in C. elegans.
PloS one
Vaccaro A,Tauffenberger A,Aggad D,Rouleau G,Drapeau P,Parker JA
Fri Jun 29 00:00:00 UTC 2012
Mutant TDP-43 and FUS cause age-dependent paralysis and neurodegeneration in C. elegans.
PloS one
Vaccaro A,Tauffenberger A,Aggad D,Rouleau G,Drapeau P,Parker JA
Fri Jun 29 00:00:00 UTC 2012
Mutant TDP-43 and FUS cause age-dependent paralysis and neurodegeneration in C. elegans.
PloS one
Vaccaro A,Tauffenberger A,Aggad D,Rouleau G,Drapeau P,Parker JA
Fri Jun 29 00:00:00 UTC 2012
Conserved acidic amino acid residues in a second RNA recognition motif regulate assembly and function of TDP-43.
PloS one
Shodai A,Ido A,Fujiwara N,Ayaki T,Morimura T,Oono M,Uchida T,Takahashi R,Ito H,Urushitani M
Thu Jun 27 00:00:00 UTC 2013
Conserved acidic amino acid residues in a second RNA recognition motif regulate assembly and function of TDP-43.
PloS one
Shodai A,Ido A,Fujiwara N,Ayaki T,Morimura T,Oono M,Uchida T,Takahashi R,Ito H,Urushitani M
Thu Jun 27 00:00:00 UTC 2013
Conserved acidic amino acid residues in a second RNA recognition motif regulate assembly and function of TDP-43.
PloS one
Shodai A,Ido A,Fujiwara N,Ayaki T,Morimura T,Oono M,Uchida T,Takahashi R,Ito H,Urushitani M
Thu Jun 27 00:00:00 UTC 2013
Conserved acidic amino acid residues in a second RNA recognition motif regulate assembly and function of TDP-43.
PloS one
Shodai A,Ido A,Fujiwara N,Ayaki T,Morimura T,Oono M,Uchida T,Takahashi R,Ito H,Urushitani M
Thu Jun 27 00:00:00 UTC 2013
Alteration of POLDIP3 splicing associated with loss of function of TDP-43 in tissues affected with ALS.
PloS one
Shiga A,Ishihara T,Miyashita A,Kuwabara M,Kato T,Watanabe N,Yamahira A,Kondo C,Yokoseki A,Takahashi M,Kuwano R,Kakita A,Nishizawa M,Takahashi H,Onodera O
Fri Mar 22 00:00:00 UTC 2013
Alteration of POLDIP3 splicing associated with loss of function of TDP-43 in tissues affected with ALS.
PloS one
Shiga A,Ishihara T,Miyashita A,Kuwabara M,Kato T,Watanabe N,Yamahira A,Kondo C,Yokoseki A,Takahashi M,Kuwano R,Kakita A,Nishizawa M,Takahashi H,Onodera O
Fri Mar 22 00:00:00 UTC 2013
Alteration of POLDIP3 splicing associated with loss of function of TDP-43 in tissues affected with ALS.
PloS one
Shiga A,Ishihara T,Miyashita A,Kuwabara M,Kato T,Watanabe N,Yamahira A,Kondo C,Yokoseki A,Takahashi M,Kuwano R,Kakita A,Nishizawa M,Takahashi H,Onodera O
Fri Mar 22 00:00:00 UTC 2013
Alteration of POLDIP3 splicing associated with loss of function of TDP-43 in tissues affected with ALS.
PloS one
Shiga A,Ishihara T,Miyashita A,Kuwabara M,Kato T,Watanabe N,Yamahira A,Kondo C,Yokoseki A,Takahashi M,Kuwano R,Kakita A,Nishizawa M,Takahashi H,Onodera O
Fri Mar 22 00:00:00 UTC 2013
Alteration of POLDIP3 splicing associated with loss of function of TDP-43 in tissues affected with ALS.
PloS one
Shiga A,Ishihara T,Miyashita A,Kuwabara M,Kato T,Watanabe N,Yamahira A,Kondo C,Yokoseki A,Takahashi M,Kuwano R,Kakita A,Nishizawa M,Takahashi H,Onodera O
Fri Mar 22 00:00:00 UTC 2013
Alteration of POLDIP3 splicing associated with loss of function of TDP-43 in tissues affected with ALS.
PloS one
Shiga A,Ishihara T,Miyashita A,Kuwabara M,Kato T,Watanabe N,Yamahira A,Kondo C,Yokoseki A,Takahashi M,Kuwano R,Kakita A,Nishizawa M,Takahashi H,Onodera O
Fri Mar 22 00:00:00 UTC 2013
Ultrastructure of ubiquitin-positive, TDP-43-negative neuronal inclusions in cerebral cortex of C9ORF72-linked frontotemporal lobar degeneration/amyotrophic lateral sclerosis.
Neuropathology : official journal of the Japanese Society of Neuropathology
Lin W,Dickson DW
Sat Dec 01 00:00:00 UTC 2012
TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like cells.
The Journal of biological chemistry
Colombrita C,Onesto E,Megiorni F,Pizzuti A,Baralle FE,Buratti E,Silani V,Ratti A
Fri May 04 00:00:00 UTC 2012
TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like cells.
The Journal of biological chemistry
Colombrita C,Onesto E,Megiorni F,Pizzuti A,Baralle FE,Buratti E,Silani V,Ratti A
Fri May 04 00:00:00 UTC 2012
TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like cells.
The Journal of biological chemistry
Colombrita C,Onesto E,Megiorni F,Pizzuti A,Baralle FE,Buratti E,Silani V,Ratti A
Fri May 04 00:00:00 UTC 2012
TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like cells.
The Journal of biological chemistry
Colombrita C,Onesto E,Megiorni F,Pizzuti A,Baralle FE,Buratti E,Silani V,Ratti A
Fri May 04 00:00:00 UTC 2012
Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis.
The Journal of biological chemistry
Tashiro Y,Urushitani M,Inoue H,Koike M,Uchiyama Y,Komatsu M,Tanaka K,Yamazaki M,Abe M,Misawa H,Sakimura K,Ito H,Takahashi R
Fri Dec 14 00:00:00 UTC 2012
Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis.
The Journal of biological chemistry
Tashiro Y,Urushitani M,Inoue H,Koike M,Uchiyama Y,Komatsu M,Tanaka K,Yamazaki M,Abe M,Misawa H,Sakimura K,Ito H,Takahashi R
Fri Dec 14 00:00:00 UTC 2012
Aberrant localization of FUS and TDP43 is associated with misfolding of SOD1 in amyotrophic lateral sclerosis.
PloS one
Pokrishevsky E,Grad LI,Yousefi M,Wang J,Mackenzie IR,Cashman NR
Tue Sep 04 00:00:00 UTC 2012
Aberrant localization of FUS and TDP43 is associated with misfolding of SOD1 in amyotrophic lateral sclerosis.
PloS one
Pokrishevsky E,Grad LI,Yousefi M,Wang J,Mackenzie IR,Cashman NR
Tue Sep 04 00:00:00 UTC 2012
Aberrant localization of FUS and TDP43 is associated with misfolding of SOD1 in amyotrophic lateral sclerosis.
PloS one
Pokrishevsky E,Grad LI,Yousefi M,Wang J,Mackenzie IR,Cashman NR
Tue Sep 04 00:00:00 UTC 2012
Aberrant localization of FUS and TDP43 is associated with misfolding of SOD1 in amyotrophic lateral sclerosis.
PloS one
Pokrishevsky E,Grad LI,Yousefi M,Wang J,Mackenzie IR,Cashman NR
Tue Sep 04 00:00:00 UTC 2012
Aberrant localization of FUS and TDP43 is associated with misfolding of SOD1 in amyotrophic lateral sclerosis.
PloS one
Pokrishevsky E,Grad LI,Yousefi M,Wang J,Mackenzie IR,Cashman NR
Tue Sep 04 00:00:00 UTC 2012
Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons.
Nature communications
Thiyagarajan N,Ferguson R,Subramanian V,Acharya KR
Fri Feb 01 00:00:00 UTC 2013
Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons.
Nature communications
Thiyagarajan N,Ferguson R,Subramanian V,Acharya KR
Fri Feb 01 00:00:00 UTC 2013
Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination.
PloS one
Dammer EB,Fallini C,Gozal YM,Duong DM,Rossoll W,Xu P,Lah JJ,Levey AI,Peng J,Bassell GJ,Seyfried NT
Tue Mar 26 00:00:00 UTC 2013
Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination.
PloS one
Dammer EB,Fallini C,Gozal YM,Duong DM,Rossoll W,Xu P,Lah JJ,Levey AI,Peng J,Bassell GJ,Seyfried NT
Tue Mar 26 00:00:00 UTC 2013
A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology.
Nature communications
Yamashita T,Hideyama T,Hachiga K,Teramoto S,Takano J,Iwata N,Saido TC,Kwak S
Tue Jun 11 00:00:00 UTC 2013
A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology.
Nature communications
Yamashita T,Hideyama T,Hachiga K,Teramoto S,Takano J,Iwata N,Saido TC,Kwak S
Tue Jun 11 00:00:00 UTC 2013
A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology.
Nature communications
Yamashita T,Hideyama T,Hachiga K,Teramoto S,Takano J,Iwata N,Saido TC,Kwak S
Tue Jun 11 00:00:00 UTC 2013
A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology.
Nature communications
Yamashita T,Hideyama T,Hachiga K,Teramoto S,Takano J,Iwata N,Saido TC,Kwak S
Tue Jun 11 00:00:00 UTC 2013
Characterization of staufen1 ribonucleoproteins by mass spectrometry and biochemical analyses reveal the presence of diverse host proteins associated with human immunodeficiency virus type 1.
Frontiers in microbiology
Milev MP,Ravichandran M,Khan MF,Schriemer DC,Mouland AJ
Tue Nov 06 00:00:00 UTC 2012
Characterization of staufen1 ribonucleoproteins by mass spectrometry and biochemical analyses reveal the presence of diverse host proteins associated with human immunodeficiency virus type 1.
Frontiers in microbiology
Milev MP,Ravichandran M,Khan MF,Schriemer DC,Mouland AJ
Tue Nov 06 00:00:00 UTC 2012
Characterization of staufen1 ribonucleoproteins by mass spectrometry and biochemical analyses reveal the presence of diverse host proteins associated with human immunodeficiency virus type 1.
Frontiers in microbiology
Milev MP,Ravichandran M,Khan MF,Schriemer DC,Mouland AJ
Tue Nov 06 00:00:00 UTC 2012
Characterization of staufen1 ribonucleoproteins by mass spectrometry and biochemical analyses reveal the presence of diverse host proteins associated with human immunodeficiency virus type 1.
Frontiers in microbiology
Milev MP,Ravichandran M,Khan MF,Schriemer DC,Mouland AJ
Tue Nov 06 00:00:00 UTC 2012
Iron accumulation in deep cortical layers accounts for MRI signal abnormalities in ALS: correlating 7 tesla MRI and pathology.
PloS one
Kwan JY,Jeong SY,Van Gelderen P,Deng HX,Quezado MM,Danielian LE,Butman JA,Chen L,Bayat E,Russell J,Siddique T,Duyn JH,Rouault TA,Floeter MK
Mon Nov 19 00:00:00 UTC 2012
Iron accumulation in deep cortical layers accounts for MRI signal abnormalities in ALS: correlating 7 tesla MRI and pathology.
PloS one
Kwan JY,Jeong SY,Van Gelderen P,Deng HX,Quezado MM,Danielian LE,Butman JA,Chen L,Bayat E,Russell J,Siddique T,Duyn JH,Rouault TA,Floeter MK
Mon Nov 19 00:00:00 UTC 2012
Minocycline-associated rimmed vacuolar myopathy in a patient with rheumatoid arthritis.
BMC neurology
Bokuda K,Sugaya K,Tamura S,Miyamoto K,Matsubara S,Komori T
Wed Nov 21 00:00:00 UTC 2012
Minocycline-associated rimmed vacuolar myopathy in a patient with rheumatoid arthritis.
BMC neurology
Bokuda K,Sugaya K,Tamura S,Miyamoto K,Matsubara S,Komori T
Wed Nov 21 00:00:00 UTC 2012
Phosphorylated tau/amyloid beta 1-42 ratio in ventricular cerebrospinal fluid reflects outcome in idiopathic normal pressure hydrocephalus.
Fluids and barriers of the CNS
Patel S,Lee EB,Xie SX,Law A,Jackson EM,Arnold SE,Clark CM,Shaw LM,Grady MS,Trojanowski JQ,Hamilton RH
Fri Mar 23 00:00:00 UTC 2012
Phosphorylated tau/amyloid beta 1-42 ratio in ventricular cerebrospinal fluid reflects outcome in idiopathic normal pressure hydrocephalus.
Fluids and barriers of the CNS
Patel S,Lee EB,Xie SX,Law A,Jackson EM,Arnold SE,Clark CM,Shaw LM,Grady MS,Trojanowski JQ,Hamilton RH
Fri Mar 23 00:00:00 UTC 2012
Cellular model of TAR DNA-binding protein 43 (TDP-43) aggregation based on its C-terminal Gln/Asn-rich region.
The Journal of biological chemistry
Budini M,Buratti E,Stuani C,Guarnaccia C,Romano V,De Conti L,Baralle FE
Fri Mar 02 00:00:00 UTC 2012
Cellular model of TAR DNA-binding protein 43 (TDP-43) aggregation based on its C-terminal Gln/Asn-rich region.
The Journal of biological chemistry
Budini M,Buratti E,Stuani C,Guarnaccia C,Romano V,De Conti L,Baralle FE
Fri Mar 02 00:00:00 UTC 2012
Aquaporin-4 expression in distal myopathy with rimmed vacuoles.
BMC neurology
Hoshi A,Yamamoto T,Kikuchi S,Soeda T,Shimizu K,Ugawa Y
Fri Apr 27 00:00:00 UTC 2012
Aquaporin-4 expression in distal myopathy with rimmed vacuoles.
BMC neurology
Hoshi A,Yamamoto T,Kikuchi S,Soeda T,Shimizu K,Ugawa Y
Fri Apr 27 00:00:00 UTC 2012
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia.
Nature
Deng HX,Chen W,Hong ST,Boycott KM,Gorrie GH,Siddique N,Yang Y,Fecto F,Shi Y,Zhai H,Jiang H,Hirano M,Rampersaud E,Jansen GH,Donkervoort S,Bigio EH,Brooks BR,Ajroud K,Sufit RL,Haines JL,Mugnaini E,Pericak-Vance MA,Siddique T
Sun Aug 21 00:00:00 UTC 2011
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia.
Nature
Deng HX,Chen W,Hong ST,Boycott KM,Gorrie GH,Siddique N,Yang Y,Fecto F,Shi Y,Zhai H,Jiang H,Hirano M,Rampersaud E,Jansen GH,Donkervoort S,Bigio EH,Brooks BR,Ajroud K,Sufit RL,Haines JL,Mugnaini E,Pericak-Vance MA,Siddique T
Sun Aug 21 00:00:00 UTC 2011
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia.
Nature
Deng HX,Chen W,Hong ST,Boycott KM,Gorrie GH,Siddique N,Yang Y,Fecto F,Shi Y,Zhai H,Jiang H,Hirano M,Rampersaud E,Jansen GH,Donkervoort S,Bigio EH,Brooks BR,Ajroud K,Sufit RL,Haines JL,Mugnaini E,Pericak-Vance MA,Siddique T
Sun Aug 21 00:00:00 UTC 2011
Characterizing the RNA targets and position-dependent splicing regulation by TDP-43.
Nature neuroscience
Tollervey JR,Curk T,Rogelj B,Briese M,Cereda M,Kayikci M,König J,Hortobágyi T,Nishimura AL,Zupunski V,Patani R,Chandran S,Rot G,Zupan B,Shaw CE,Ule J
Fri Apr 01 00:00:00 UTC 2011
Characterizing the RNA targets and position-dependent splicing regulation by TDP-43.
Nature neuroscience
Tollervey JR,Curk T,Rogelj B,Briese M,Cereda M,Kayikci M,König J,Hortobágyi T,Nishimura AL,Zupunski V,Patani R,Chandran S,Rot G,Zupan B,Shaw CE,Ule J
Fri Apr 01 00:00:00 UTC 2011
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.
Nature neuroscience
Polymenidou M,Lagier-Tourenne C,Hutt KR,Huelga SC,Moran J,Liang TY,Ling SC,Sun E,Wancewicz E,Mazur C,Kordasiewicz H,Sedaghat Y,Donohue JP,Shiue L,Bennett CF,Yeo GW,Cleveland DW
Fri Apr 01 00:00:00 UTC 2011
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.
Nature neuroscience
Polymenidou M,Lagier-Tourenne C,Hutt KR,Huelga SC,Moran J,Liang TY,Ling SC,Sun E,Wancewicz E,Mazur C,Kordasiewicz H,Sedaghat Y,Donohue JP,Shiue L,Bennett CF,Yeo GW,Cleveland DW
Fri Apr 01 00:00:00 UTC 2011
Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice.
The Journal of clinical investigation
Igaz LM,Kwong LK,Lee EB,Chen-Plotkin A,Swanson E,Unger T,Malunda J,Xu Y,Winton MJ,Trojanowski JQ,Lee VM
Tue Feb 01 00:00:00 UTC 2011
Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice.
The Journal of clinical investigation
Igaz LM,Kwong LK,Lee EB,Chen-Plotkin A,Swanson E,Unger T,Malunda J,Xu Y,Winton MJ,Trojanowski JQ,Lee VM
Tue Feb 01 00:00:00 UTC 2011
Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice.
The Journal of clinical investigation
Igaz LM,Kwong LK,Lee EB,Chen-Plotkin A,Swanson E,Unger T,Malunda J,Xu Y,Winton MJ,Trojanowski JQ,Lee VM
Tue Feb 01 00:00:00 UTC 2011
Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice.
The Journal of clinical investigation
Igaz LM,Kwong LK,Lee EB,Chen-Plotkin A,Swanson E,Unger T,Malunda J,Xu Y,Winton MJ,Trojanowski JQ,Lee VM
Tue Feb 01 00:00:00 UTC 2011
An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity.
Nature structural & molecular biology
Guo W,Chen Y,Zhou X,Kar A,Ray P,Chen X,Rao EJ,Yang M,Ye H,Zhu L,Liu J,Xu M,Yang Y,Wang C,Zhang D,Bigio EH,Mesulam M,Shen Y,Xu Q,Fushimi K,Wu JY
Sun Jun 12 00:00:00 UTC 2011
An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity.
Nature structural & molecular biology
Guo W,Chen Y,Zhou X,Kar A,Ray P,Chen X,Rao EJ,Yang M,Ye H,Zhu L,Liu J,Xu M,Yang Y,Wang C,Zhang D,Bigio EH,Mesulam M,Shen Y,Xu Q,Fushimi K,Wu JY
Sun Jun 12 00:00:00 UTC 2011
An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity.
Nature structural & molecular biology
Guo W,Chen Y,Zhou X,Kar A,Ray P,Chen X,Rao EJ,Yang M,Ye H,Zhu L,Liu J,Xu M,Yang Y,Wang C,Zhang D,Bigio EH,Mesulam M,Shen Y,Xu Q,Fushimi K,Wu JY
Sun Jun 12 00:00:00 UTC 2011
An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity.
Nature structural & molecular biology
Guo W,Chen Y,Zhou X,Kar A,Ray P,Chen X,Rao EJ,Yang M,Ye H,Zhu L,Liu J,Xu M,Yang Y,Wang C,Zhang D,Bigio EH,Mesulam M,Shen Y,Xu Q,Fushimi K,Wu JY
Sun Jun 12 00:00:00 UTC 2011
Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB-mediated pathogenic pathways.
The Journal of experimental medicine
Swarup V,Phaneuf D,Dupré N,Petri S,Strong M,Kriz J,Julien JP
Mon Nov 21 00:00:00 UTC 2011
Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB-mediated pathogenic pathways.
The Journal of experimental medicine
Swarup V,Phaneuf D,Dupré N,Petri S,Strong M,Kriz J,Julien JP
Mon Nov 21 00:00:00 UTC 2011
Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB-mediated pathogenic pathways.
The Journal of experimental medicine
Swarup V,Phaneuf D,Dupré N,Petri S,Strong M,Kriz J,Julien JP
Mon Nov 21 00:00:00 UTC 2011
Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB-mediated pathogenic pathways.
The Journal of experimental medicine
Swarup V,Phaneuf D,Dupré N,Petri S,Strong M,Kriz J,Julien JP
Mon Nov 21 00:00:00 UTC 2011
Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB-mediated pathogenic pathways.
The Journal of experimental medicine
Swarup V,Phaneuf D,Dupré N,Petri S,Strong M,Kriz J,Julien JP
Mon Nov 21 00:00:00 UTC 2011
Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB-mediated pathogenic pathways.
The Journal of experimental medicine
Swarup V,Phaneuf D,Dupré N,Petri S,Strong M,Kriz J,Julien JP
Mon Nov 21 00:00:00 UTC 2011
TDP-43 pathological changes in early onset familial and sporadic Alzheimer's disease, late onset Alzheimer's disease and Down's syndrome: association with age, hippocampal sclerosis and clinical phenotype.
Acta neuropathologica
Davidson YS,Raby S,Foulds PG,Robinson A,Thompson JC,Sikkink S,Yusuf I,Amin H,DuPlessis D,Troakes C,Al-Sarraj S,Sloan C,Esiri MM,Prasher VP,Allsop D,Neary D,Pickering-Brown SM,Snowden JS,Mann DM
Thu Dec 01 00:00:00 UTC 2011
TDP-43 pathological changes in early onset familial and sporadic Alzheimer's disease, late onset Alzheimer's disease and Down's syndrome: association with age, hippocampal sclerosis and clinical phenotype.
Acta neuropathologica
Davidson YS,Raby S,Foulds PG,Robinson A,Thompson JC,Sikkink S,Yusuf I,Amin H,DuPlessis D,Troakes C,Al-Sarraj S,Sloan C,Esiri MM,Prasher VP,Allsop D,Neary D,Pickering-Brown SM,Snowden JS,Mann DM
Thu Dec 01 00:00:00 UTC 2011
Acute and chronically increased immunoreactivity to phosphorylation-independent but not pathological TDP-43 after a single traumatic brain injury in humans.
Acta neuropathologica
Johnson VE,Stewart W,Trojanowski JQ,Smith DH
Thu Dec 01 00:00:00 UTC 2011
Acute and chronically increased immunoreactivity to phosphorylation-independent but not pathological TDP-43 after a single traumatic brain injury in humans.
Acta neuropathologica
Johnson VE,Stewart W,Trojanowski JQ,Smith DH
Thu Dec 01 00:00:00 UTC 2011
Clinicopathologic study on an ALS family with a heterozygous E478G optineurin mutation.
Acta neuropathologica
Ito H,Nakamura M,Komure O,Ayaki T,Wate R,Maruyama H,Nakamura Y,Fujita K,Kaneko S,Okamoto Y,Ihara M,Konishi T,Ogasawara K,Hirano A,Kusaka H,Kaji R,Takahashi R,Kawakami H
Mon Aug 01 00:00:00 UTC 2011
Clinicopathologic study on an ALS family with a heterozygous E478G optineurin mutation.
Acta neuropathologica
Ito H,Nakamura M,Komure O,Ayaki T,Wate R,Maruyama H,Nakamura Y,Fujita K,Kaneko S,Okamoto Y,Ihara M,Konishi T,Ogasawara K,Hirano A,Kusaka H,Kaji R,Takahashi R,Kawakami H
Mon Aug 01 00:00:00 UTC 2011
A peculiar constellation of tau pathology defines a subset of dementia in the elderly.
Acta neuropathologica
Kovacs GG,Molnár K,László L,Ströbel T,Botond G,Hönigschnabl S,Reiner-Concin A,Palkovits M,Fischer P,Budka H
Mon Aug 01 00:00:00 UTC 2011
A peculiar constellation of tau pathology defines a subset of dementia in the elderly.
Acta neuropathologica
Kovacs GG,Molnár K,László L,Ströbel T,Botond G,Hönigschnabl S,Reiner-Concin A,Palkovits M,Fischer P,Budka H
Mon Aug 01 00:00:00 UTC 2011
Motor neuron disease clinically limited to the lower motor neuron is a diffuse TDP-43 proteinopathy.
Acta neuropathologica
Geser F,Stein B,Partain M,Elman LB,McCluskey LF,Xie SX,Van Deerlin VM,Kwong LK,Lee VM,Trojanowski JQ
Fri Apr 01 00:00:00 UTC 2011
Motor neuron disease clinically limited to the lower motor neuron is a diffuse TDP-43 proteinopathy.
Acta neuropathologica
Geser F,Stein B,Partain M,Elman LB,McCluskey LF,Xie SX,Van Deerlin VM,Kwong LK,Lee VM,Trojanowski JQ
Fri Apr 01 00:00:00 UTC 2011
The most common type of FTLD-FUS (aFTLD-U) is associated with a distinct clinical form of frontotemporal dementia but is not related to mutations in the FUS gene.
Acta neuropathologica
Snowden JS,Hu Q,Rollinson S,Halliwell N,Robinson A,Davidson YS,Momeni P,Baborie A,Griffiths TD,Jaros E,Perry RH,Richardson A,Pickering-Brown SM,Neary D,Mann DM
Fri Jul 01 00:00:00 UTC 2011
The most common type of FTLD-FUS (aFTLD-U) is associated with a distinct clinical form of frontotemporal dementia but is not related to mutations in the FUS gene.
Acta neuropathologica
Snowden JS,Hu Q,Rollinson S,Halliwell N,Robinson A,Davidson YS,Momeni P,Baborie A,Griffiths TD,Jaros E,Perry RH,Richardson A,Pickering-Brown SM,Neary D,Mann DM
Fri Jul 01 00:00:00 UTC 2011
Granular expression of prolyl-peptidyl isomerase PIN1 is a constant and specific feature of Alzheimer's disease pathology and is independent of tau, Aβ and TDP-43 pathology.
Acta neuropathologica
Dakson A,Yokota O,Esiri M,Bigio EH,Horan M,Pendleton N,Richardson A,Neary D,Snowden JS,Robinson A,Davidson YS,Mann DM
Sun May 01 00:00:00 UTC 2011
Granular expression of prolyl-peptidyl isomerase PIN1 is a constant and specific feature of Alzheimer's disease pathology and is independent of tau, Aβ and TDP-43 pathology.
Acta neuropathologica
Dakson A,Yokota O,Esiri M,Bigio EH,Horan M,Pendleton N,Richardson A,Neary D,Snowden JS,Robinson A,Davidson YS,Mann DM
Sun May 01 00:00:00 UTC 2011
New neuropathological findings in Unverricht-Lundborg disease: neuronal intranuclear and cytoplasmic inclusions.
Acta neuropathologica
Cohen NR,Hammans SR,Macpherson J,Nicoll JA
Tue Mar 01 00:00:00 UTC 2011
New neuropathological findings in Unverricht-Lundborg disease: neuronal intranuclear and cytoplasmic inclusions.
Acta neuropathologica
Cohen NR,Hammans SR,Macpherson J,Nicoll JA
Tue Mar 01 00:00:00 UTC 2011
Spinocerebellar ataxia type 2 (SCA2) is associated with TDP-43 pathology.
Acta neuropathologica
Toyoshima Y,Tanaka H,Shimohata M,Kimura K,Morita T,Kakita A,Takahashi H
Thu Sep 01 00:00:00 UTC 2011
Spinocerebellar ataxia type 2 (SCA2) is associated with TDP-43 pathology.
Acta neuropathologica
Toyoshima Y,Tanaka H,Shimohata M,Kimura K,Morita T,Kakita A,Takahashi H
Thu Sep 01 00:00:00 UTC 2011
TDP-43 pathology may occur in the BRI2 gene-related dementias.
Acta neuropathologica
Lashley T,Holton JL,Revesz T
Fri Apr 01 00:00:00 UTC 2011
TDP-43 pathology may occur in the BRI2 gene-related dementias.
Acta neuropathologica
Lashley T,Holton JL,Revesz T
Fri Apr 01 00:00:00 UTC 2011
Pathological correlates of frontotemporal lobar degeneration in the elderly.
Acta neuropathologica
Baborie A,Griffiths TD,Jaros E,McKeith IG,Burn DJ,Richardson A,Ferrari R,Moreno J,Momeni P,Duplessis D,Pal P,Rollinson S,Pickering-Brown S,Thompson JC,Neary D,Snowden JS,Perry R,Mann DM
Tue Mar 01 00:00:00 UTC 2011
Pathological correlates of frontotemporal lobar degeneration in the elderly.
Acta neuropathologica
Baborie A,Griffiths TD,Jaros E,McKeith IG,Burn DJ,Richardson A,Ferrari R,Moreno J,Momeni P,Duplessis D,Pal P,Rollinson S,Pickering-Brown S,Thompson JC,Neary D,Snowden JS,Perry R,Mann DM
Tue Mar 01 00:00:00 UTC 2011
Novel histopathologic findings in molecularly-confirmed pantothenate kinase-associated neurodegeneration.
Brain : a journal of neurology
Kruer MC,Hiken M,Gregory A,Malandrini A,Clark D,Hogarth P,Grafe M,Hayflick SJ,Woltjer RL
Fri Apr 01 00:00:00 UTC 2011
Novel histopathologic findings in molecularly-confirmed pantothenate kinase-associated neurodegeneration.
Brain : a journal of neurology
Kruer MC,Hiken M,Gregory A,Malandrini A,Clark D,Hogarth P,Grafe M,Hayflick SJ,Woltjer RL
Fri Apr 01 00:00:00 UTC 2011
Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments.
Brain : a journal of neurology
Swarup V,Phaneuf D,Bareil C,Robertson J,Rouleau GA,Kriz J,Julien JP
Thu Sep 01 00:00:00 UTC 2011
Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments.
Brain : a journal of neurology
Swarup V,Phaneuf D,Bareil C,Robertson J,Rouleau GA,Kriz J,Julien JP
Thu Sep 01 00:00:00 UTC 2011
Long-term observational study of sporadic inclusion body myositis.
Brain : a journal of neurology
Benveniste O,Guiguet M,Freebody J,Dubourg O,Squier W,Maisonobe T,Stojkovic T,Leite MI,Allenbach Y,Herson S,Brady S,Eymard B,Hilton-Jones D
Tue Nov 01 00:00:00 UTC 2011
Long-term observational study of sporadic inclusion body myositis.
Brain : a journal of neurology
Benveniste O,Guiguet M,Freebody J,Dubourg O,Squier W,Maisonobe T,Stojkovic T,Leite MI,Allenbach Y,Herson S,Brady S,Eymard B,Hilton-Jones D
Tue Nov 01 00:00:00 UTC 2011
Hippocampal sclerosis in advanced age: clinical and pathological features.
Brain : a journal of neurology
Nelson PT,Schmitt FA,Lin Y,Abner EL,Jicha GA,Patel E,Thomason PC,Neltner JH,Smith CD,Santacruz KS,Sonnen JA,Poon LW,Gearing M,Green RC,Woodard JL,Van Eldik LJ,Kryscio RJ
Sun May 01 00:00:00 UTC 2011
Hippocampal sclerosis in advanced age: clinical and pathological features.
Brain : a journal of neurology
Nelson PT,Schmitt FA,Lin Y,Abner EL,Jicha GA,Patel E,Thomason PC,Neltner JH,Smith CD,Santacruz KS,Sonnen JA,Poon LW,Gearing M,Green RC,Woodard JL,Van Eldik LJ,Kryscio RJ
Sun May 01 00:00:00 UTC 2011
The clinical diagnosis of early-onset dementias: diagnostic accuracy and clinicopathological relationships.
Brain : a journal of neurology
Snowden JS,Thompson JC,Stopford CL,Richardson AM,Gerhard A,Neary D,Mann DM
Thu Sep 01 00:00:00 UTC 2011
The clinical diagnosis of early-onset dementias: diagnostic accuracy and clinicopathological relationships.
Brain : a journal of neurology
Snowden JS,Thompson JC,Stopford CL,Richardson AM,Gerhard A,Neary D,Mann DM
Thu Sep 01 00:00:00 UTC 2011
TDP-43 regulates its mRNA levels through a negative feedback loop.
The EMBO journal
Ayala YM,De Conti L,Avendaño-Vázquez SE,Dhir A,Romano M,D'Ambrogio A,Tollervey J,Ule J,Baralle M,Buratti E,Baralle FE
Wed Jan 19 00:00:00 UTC 2011
TDP-43 regulates its mRNA levels through a negative feedback loop.
The EMBO journal
Ayala YM,De Conti L,Avendaño-Vázquez SE,Dhir A,Romano M,D'Ambrogio A,Tollervey J,Ule J,Baralle M,Buratti E,Baralle FE
Wed Jan 19 00:00:00 UTC 2011
Clinical, neuroimaging and neuropathological features of a new chromosome 9p-linked FTD-ALS family.
Journal of neurology, neurosurgery, and psychiatry
Boxer AL,Mackenzie IR,Boeve BF,Baker M,Seeley WW,Crook R,Feldman H,Hsiung GY,Rutherford N,Laluz V,Whitwell J,Foti D,McDade E,Molano J,Karydas A,Wojtas A,Goldman J,Mirsky J,Sengdy P,Dearmond S,Miller BL,Rademakers R
Tue Feb 01 00:00:00 UTC 2011
Clinical, neuroimaging and neuropathological features of a new chromosome 9p-linked FTD-ALS family.
Journal of neurology, neurosurgery, and psychiatry
Boxer AL,Mackenzie IR,Boeve BF,Baker M,Seeley WW,Crook R,Feldman H,Hsiung GY,Rutherford N,Laluz V,Whitwell J,Foti D,McDade E,Molano J,Karydas A,Wojtas A,Goldman J,Mirsky J,Sengdy P,Dearmond S,Miller BL,Rademakers R
Tue Feb 01 00:00:00 UTC 2011
Abnormal TDP-43 and FUS proteins in muscles of sporadic IBM: similarities in a TARDBP-linked ALS patient.
Journal of neurology, neurosurgery, and psychiatry
Hernandez Lain A,Millecamps S,Dubourg O,Salachas F,Bruneteau G,Lacomblez L,LeGuern E,Seilhean D,Duyckaerts C,Meininger V,Mallet J,Pradat PF
Thu Dec 01 00:00:00 UTC 2011
Abnormal TDP-43 and FUS proteins in muscles of sporadic IBM: similarities in a TARDBP-linked ALS patient.
Journal of neurology, neurosurgery, and psychiatry
Hernandez Lain A,Millecamps S,Dubourg O,Salachas F,Bruneteau G,Lacomblez L,LeGuern E,Seilhean D,Duyckaerts C,Meininger V,Mallet J,Pradat PF
Thu Dec 01 00:00:00 UTC 2011
Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Papadeas ST,Kraig SE,O'Banion C,Lepore AC,Maragakis NJ
Tue Oct 25 00:00:00 UTC 2011
Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Papadeas ST,Kraig SE,O'Banion C,Lepore AC,Maragakis NJ
Tue Oct 25 00:00:00 UTC 2011
An autopsy case of SOD1-related ALS with TDP-43 positive inclusions.
Neurology
Okamoto Y,Ihara M,Urushitani M,Yamashita H,Kondo T,Tanigaki A,Oono M,Kawamata J,Ikemoto A,Kawamoto Y,Takahashi R,Ito H
Tue Nov 29 00:00:00 UTC 2011
An autopsy case of SOD1-related ALS with TDP-43 positive inclusions.
Neurology
Okamoto Y,Ihara M,Urushitani M,Yamashita H,Kondo T,Tanigaki A,Oono M,Kawamata J,Ikemoto A,Kawamoto Y,Takahashi R,Ito H
Tue Nov 29 00:00:00 UTC 2011
A family with Parkinsonism, essential tremor, restless legs syndrome, and depression.
Neurology
Puschmann A,Pfeiffer RF,Stoessl AJ,Kuriakose R,Lash JL,Searcy JA,Strongosky AJ,Vilariño-Güell C,Farrer MJ,Ross OA,Dickson DW,Wszolek ZK
Tue May 10 00:00:00 UTC 2011
A family with Parkinsonism, essential tremor, restless legs syndrome, and depression.
Neurology
Puschmann A,Pfeiffer RF,Stoessl AJ,Kuriakose R,Lash JL,Searcy JA,Strongosky AJ,Vilariño-Güell C,Farrer MJ,Ross OA,Dickson DW,Wszolek ZK
Tue May 10 00:00:00 UTC 2011
Nuclear transport impairment of amyotrophic lateral sclerosis-linked mutations in FUS/TLS.
Annals of neurology
Ito D,Seki M,Tsunoda Y,Uchiyama H,Suzuki N
Sat Jan 01 00:00:00 UTC 2011
Nuclear transport impairment of amyotrophic lateral sclerosis-linked mutations in FUS/TLS.
Annals of neurology
Ito D,Seki M,Tsunoda Y,Uchiyama H,Suzuki N
Sat Jan 01 00:00:00 UTC 2011
Familial prion disease with Alzheimer disease-like tau pathology and clinical phenotype.
Annals of neurology
Jayadev S,Nochlin D,Poorkaj P,Steinbart EJ,Mastrianni JA,Montine TJ,Ghetti B,Schellenberg GD,Bird TD,Leverenz JB
Fri Apr 01 00:00:00 UTC 2011
Familial prion disease with Alzheimer disease-like tau pathology and clinical phenotype.
Annals of neurology
Jayadev S,Nochlin D,Poorkaj P,Steinbart EJ,Mastrianni JA,Montine TJ,Ghetti B,Schellenberg GD,Bird TD,Leverenz JB
Fri Apr 01 00:00:00 UTC 2011
The ALS/PDC syndrome of Guam: potential biomarkers for an enigmatic disorder.
Progress in neurobiology
McGeer PL,Steele JC
Thu Dec 01 00:00:00 UTC 2011
The ALS/PDC syndrome of Guam: potential biomarkers for an enigmatic disorder.
Progress in neurobiology
McGeer PL,Steele JC
Thu Dec 01 00:00:00 UTC 2011
Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in Drosophila models of TDP-43 proteinopathies.
Neurobiology of disease
Miguel L,Frébourg T,Campion D,Lecourtois M
Tue Feb 01 00:00:00 UTC 2011
Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in Drosophila models of TDP-43 proteinopathies.
Neurobiology of disease
Miguel L,Frébourg T,Campion D,Lecourtois M
Tue Feb 01 00:00:00 UTC 2011
Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in Drosophila models of TDP-43 proteinopathies.
Neurobiology of disease
Miguel L,Frébourg T,Campion D,Lecourtois M
Tue Feb 01 00:00:00 UTC 2011
Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in Drosophila models of TDP-43 proteinopathies.
Neurobiology of disease
Miguel L,Frébourg T,Campion D,Lecourtois M
Tue Feb 01 00:00:00 UTC 2011
Familial frontotemporal dementia with amyotrophic lateral sclerosis and a shared haplotype on chromosome 9p.
Journal of neurology
Pearson JP,Williams NM,Majounie E,Waite A,Stott J,Newsway V,Murray A,Hernandez D,Guerreiro R,Singleton AB,Neal J,Morris HR
Fri Apr 01 00:00:00 UTC 2011
Familial frontotemporal dementia with amyotrophic lateral sclerosis and a shared haplotype on chromosome 9p.
Journal of neurology
Pearson JP,Williams NM,Majounie E,Waite A,Stott J,Newsway V,Murray A,Hernandez D,Guerreiro R,Singleton AB,Neal J,Morris HR
Fri Apr 01 00:00:00 UTC 2011
TDP-43 pathology occurs infrequently in multiple system atrophy.
Neuropathology and applied neurobiology
Geser F,Malunda JA,Hurtig HI,Duda JE,Wenning GK,Gilman S,Low PA,Lee VM,Trojanowski JQ
Wed Jun 01 00:00:00 UTC 2011
TDP-43 pathology occurs infrequently in multiple system atrophy.
Neuropathology and applied neurobiology
Geser F,Malunda JA,Hurtig HI,Duda JE,Wenning GK,Gilman S,Low PA,Lee VM,Trojanowski JQ
Wed Jun 01 00:00:00 UTC 2011
TDP-43 pathology occurs infrequently in multiple system atrophy.
Neuropathology and applied neurobiology
Geser F,Malunda JA,Hurtig HI,Duda JE,Wenning GK,Gilman S,Low PA,Lee VM,Trojanowski JQ
Wed Jun 01 00:00:00 UTC 2011
In sporadic inclusion body myositis muscle fibres TDP-43-positive inclusions are less frequent and robust than p62 inclusions, and are not associated with paired helical filaments.
Neuropathology and applied neurobiology
D'Agostino C,Nogalska A,Engel WK,Askanas V
Fri Apr 01 00:00:00 UTC 2011
In sporadic inclusion body myositis muscle fibres TDP-43-positive inclusions are less frequent and robust than p62 inclusions, and are not associated with paired helical filaments.
Neuropathology and applied neurobiology
D'Agostino C,Nogalska A,Engel WK,Askanas V
Fri Apr 01 00:00:00 UTC 2011
A comprehensive assessment of the SOD1G93A low-copy transgenic mouse, which models human amyotrophic lateral sclerosis.
Disease models & mechanisms
Acevedo-Arozena A,Kalmar B,Essa S,Ricketts T,Joyce P,Kent R,Rowe C,Parker A,Gray A,Hafezparast M,Thorpe JR,Greensmith L,Fisher EM
Thu Sep 01 00:00:00 UTC 2011
A comprehensive assessment of the SOD1G93A low-copy transgenic mouse, which models human amyotrophic lateral sclerosis.
Disease models & mechanisms
Acevedo-Arozena A,Kalmar B,Essa S,Ricketts T,Joyce P,Kent R,Rowe C,Parker A,Gray A,Hafezparast M,Thorpe JR,Greensmith L,Fisher EM
Thu Sep 01 00:00:00 UTC 2011
Regulation of TDP-43 aggregation by phosphorylation and p62/SQSTM1.
Journal of neurochemistry
Brady OA,Meng P,Zheng Y,Mao Y,Hu F
Sat Jan 01 00:00:00 UTC 2011
Regulation of TDP-43 aggregation by phosphorylation and p62/SQSTM1.
Journal of neurochemistry
Brady OA,Meng P,Zheng Y,Mao Y,Hu F
Sat Jan 01 00:00:00 UTC 2011
Regulation of TDP-43 aggregation by phosphorylation and p62/SQSTM1.
Journal of neurochemistry
Brady OA,Meng P,Zheng Y,Mao Y,Hu F
Sat Jan 01 00:00:00 UTC 2011
Regulation of TDP-43 aggregation by phosphorylation and p62/SQSTM1.
Journal of neurochemistry
Brady OA,Meng P,Zheng Y,Mao Y,Hu F
Sat Jan 01 00:00:00 UTC 2011
Regulation of TDP-43 aggregation by phosphorylation and p62/SQSTM1.
Journal of neurochemistry
Brady OA,Meng P,Zheng Y,Mao Y,Hu F
Sat Jan 01 00:00:00 UTC 2011
Regulation of TDP-43 aggregation by phosphorylation and p62/SQSTM1.
Journal of neurochemistry
Brady OA,Meng P,Zheng Y,Mao Y,Hu F
Sat Jan 01 00:00:00 UTC 2011
Catastrophic hyperkalaemia following administration of suxamethonium chloride to a patient with undiagnosed amyotrophic lateral sclerosis.
Clinical medicine (London, England)
Turner MR,Lawrence H,Arnold I,Ansorge O,Talbot K
Wed Jun 01 00:00:00 UTC 2011
Catastrophic hyperkalaemia following administration of suxamethonium chloride to a patient with undiagnosed amyotrophic lateral sclerosis.
Clinical medicine (London, England)
Turner MR,Lawrence H,Arnold I,Ansorge O,Talbot K
Wed Jun 01 00:00:00 UTC 2011
Temporoparietal atrophy: a marker of AD pathology independent of clinical diagnosis.
Neurobiology of aging
Whitwell JL,Jack CR,Przybelski SA,Parisi JE,Senjem ML,Boeve BF,Knopman DS,Petersen RC,Dickson DW,Josephs KA
Thu Sep 01 00:00:00 UTC 2011
Temporoparietal atrophy: a marker of AD pathology independent of clinical diagnosis.
Neurobiology of aging
Whitwell JL,Jack CR,Przybelski SA,Parisi JE,Senjem ML,Boeve BF,Knopman DS,Petersen RC,Dickson DW,Josephs KA
Thu Sep 01 00:00:00 UTC 2011
A novel double mutation in FUS gene causing sporadic ALS.
Neurobiology of aging
Robertson J,Bilbao J,Zinman L,Hazrati LN,Tokuhiro S,Sato C,Moreno D,Strome R,Mackenzie IR,Rogaeva E
Tue Mar 01 00:00:00 UTC 2011
A novel double mutation in FUS gene causing sporadic ALS.
Neurobiology of aging
Robertson J,Bilbao J,Zinman L,Hazrati LN,Tokuhiro S,Sato C,Moreno D,Strome R,Mackenzie IR,Rogaeva E
Tue Mar 01 00:00:00 UTC 2011
TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling.
Human molecular genetics
Zhang T,Mullane PC,Periz G,Wang J
Sun May 15 00:00:00 UTC 2011
TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling.
Human molecular genetics
Zhang T,Mullane PC,Periz G,Wang J
Sun May 15 00:00:00 UTC 2011
TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1.
Human molecular genetics
McDonald KK,Aulas A,Destroismaisons L,Pickles S,Beleac E,Camu W,Rouleau GA,Vande Velde C
Fri Apr 01 00:00:00 UTC 2011
TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1.
Human molecular genetics
McDonald KK,Aulas A,Destroismaisons L,Pickles S,Beleac E,Camu W,Rouleau GA,Vande Velde C
Fri Apr 01 00:00:00 UTC 2011
TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1.
Human molecular genetics
McDonald KK,Aulas A,Destroismaisons L,Pickles S,Beleac E,Camu W,Rouleau GA,Vande Velde C
Fri Apr 01 00:00:00 UTC 2011
TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1.
Human molecular genetics
McDonald KK,Aulas A,Destroismaisons L,Pickles S,Beleac E,Camu W,Rouleau GA,Vande Velde C
Fri Apr 01 00:00:00 UTC 2011
A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43.
Human molecular genetics
Lanson NA,Maltare A,King H,Smith R,Kim JH,Taylor JP,Lloyd TE,Pandey UB
Fri Jul 01 00:00:00 UTC 2011
A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43.
Human molecular genetics
Lanson NA,Maltare A,King H,Smith R,Kim JH,Taylor JP,Lloyd TE,Pandey UB
Fri Jul 01 00:00:00 UTC 2011
TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor.
Molecular and cellular biology
Dewey CM,Cenik B,Sephton CF,Dries DR,Mayer P,Good SK,Johnson BA,Herz J,Yu G
Tue Mar 01 00:00:00 UTC 2011
TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor.
Molecular and cellular biology
Dewey CM,Cenik B,Sephton CF,Dries DR,Mayer P,Good SK,Johnson BA,Herz J,Yu G
Tue Mar 01 00:00:00 UTC 2011
TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor.
Molecular and cellular biology
Dewey CM,Cenik B,Sephton CF,Dries DR,Mayer P,Good SK,Johnson BA,Herz J,Yu G
Tue Mar 01 00:00:00 UTC 2011
TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor.
Molecular and cellular biology
Dewey CM,Cenik B,Sephton CF,Dries DR,Mayer P,Good SK,Johnson BA,Herz J,Yu G
Tue Mar 01 00:00:00 UTC 2011
RNA targets of TDP-43 identified by UV-CLIP are deregulated in ALS.
Molecular and cellular neurosciences
Xiao S,Sanelli T,Dib S,Sheps D,Findlater J,Bilbao J,Keith J,Zinman L,Rogaeva E,Robertson J
Fri Jul 01 00:00:00 UTC 2011
RNA targets of TDP-43 identified by UV-CLIP are deregulated in ALS.
Molecular and cellular neurosciences
Xiao S,Sanelli T,Dib S,Sheps D,Findlater J,Bilbao J,Keith J,Zinman L,Rogaeva E,Robertson J
Fri Jul 01 00:00:00 UTC 2011
FALS with Gly72Ser mutation in SOD1 gene: report of a family including the first autopsy case.
Journal of the neurological sciences
Kobayashi Z,Tsuchiya K,Kubodera T,Shibata N,Arai T,Miura H,Ishikawa C,Kondo H,Ishizu H,Akiyama H,Mizusawa H
Sat Jan 15 00:00:00 UTC 2011
FALS with Gly72Ser mutation in SOD1 gene: report of a family including the first autopsy case.
Journal of the neurological sciences
Kobayashi Z,Tsuchiya K,Kubodera T,Shibata N,Arai T,Miura H,Ishikawa C,Kondo H,Ishizu H,Akiyama H,Mizusawa H
Sat Jan 15 00:00:00 UTC 2011
Clinicopathological study of diffuse neurofibrillary tangles with calcification. With special reference to TDP-43 proteinopathy and alpha-synucleinopathy.
Journal of the neurological sciences
Habuchi C,Iritani S,Sekiguchi H,Torii Y,Ishihara R,Arai T,Hasegawa M,Tsuchiya K,Akiyama H,Shibayama H,Ozaki N
Tue Feb 15 00:00:00 UTC 2011
Clinicopathological study of diffuse neurofibrillary tangles with calcification. With special reference to TDP-43 proteinopathy and alpha-synucleinopathy.
Journal of the neurological sciences
Habuchi C,Iritani S,Sekiguchi H,Torii Y,Ishihara R,Arai T,Hasegawa M,Tsuchiya K,Akiyama H,Shibayama H,Ozaki N
Tue Feb 15 00:00:00 UTC 2011
Inorganic mercury within motor neurons does not cause the TDP-43 changes seen in sporadic ALS.
Toxicology letters
Pamphlett R,Kum Jew S
Fri Feb 25 00:00:00 UTC 2011
Inorganic mercury within motor neurons does not cause the TDP-43 changes seen in sporadic ALS.
Toxicology letters
Pamphlett R,Kum Jew S
Fri Feb 25 00:00:00 UTC 2011
Fronto-temporal lobar degeneration: neuropathology in 60 cases.
Journal of neural transmission (Vienna, Austria : 1996)
Seilhean D,Le Ber I,Sarazin M,Lacomblez L,Millecamps S,Salachas F,Pradat PF,Le Forestier N,LeGuern E,Dubois B,Meininger V,Brice A,Hauw JJ,Duyckaerts C
Sun May 01 00:00:00 UTC 2011
Fronto-temporal lobar degeneration: neuropathology in 60 cases.
Journal of neural transmission (Vienna, Austria : 1996)
Seilhean D,Le Ber I,Sarazin M,Lacomblez L,Millecamps S,Salachas F,Pradat PF,Le Forestier N,LeGuern E,Dubois B,Meininger V,Brice A,Hauw JJ,Duyckaerts C
Sun May 01 00:00:00 UTC 2011
Spatial patterns of TDP-43 neuronal cytoplasmic inclusions (NCI) in fifteen cases of frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP).
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Armstrong RA,Cairns NJ
Mon Aug 01 00:00:00 UTC 2011
Spatial patterns of TDP-43 neuronal cytoplasmic inclusions (NCI) in fifteen cases of frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP).
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Armstrong RA,Cairns NJ
Mon Aug 01 00:00:00 UTC 2011
β-amyloid triggers ALS-associated TDP-43 pathology in AD models.
Brain research
Herman AM,Khandelwal PJ,Stanczyk BB,Rebeck GW,Moussa CE
Fri Apr 22 00:00:00 UTC 2011
β-amyloid triggers ALS-associated TDP-43 pathology in AD models.
Brain research
Herman AM,Khandelwal PJ,Stanczyk BB,Rebeck GW,Moussa CE
Fri Apr 22 00:00:00 UTC 2011
β-amyloid triggers ALS-associated TDP-43 pathology in AD models.
Brain research
Herman AM,Khandelwal PJ,Stanczyk BB,Rebeck GW,Moussa CE
Fri Apr 22 00:00:00 UTC 2011
β-amyloid triggers ALS-associated TDP-43 pathology in AD models.
Brain research
Herman AM,Khandelwal PJ,Stanczyk BB,Rebeck GW,Moussa CE
Fri Apr 22 00:00:00 UTC 2011
Prevention of motor neuron degeneration by novel iron chelators in SOD1(G93A) transgenic mice of amyotrophic lateral sclerosis.
Neuro-degenerative diseases
Wang Q,Zhang X,Chen S,Zhang X,Zhang S,Youdium M,Le W
Tue May 08 00:00:00 UTC 2012
Prevention of motor neuron degeneration by novel iron chelators in SOD1(G93A) transgenic mice of amyotrophic lateral sclerosis.
Neuro-degenerative diseases
Wang Q,Zhang X,Chen S,Zhang X,Zhang S,Youdium M,Le W
Tue May 08 00:00:00 UTC 2012
Prevention of motor neuron degeneration by novel iron chelators in SOD1(G93A) transgenic mice of amyotrophic lateral sclerosis.
Neuro-degenerative diseases
Wang Q,Zhang X,Chen S,Zhang X,Zhang S,Youdium M,Le W
Tue May 08 00:00:00 UTC 2012
Prevention of motor neuron degeneration by novel iron chelators in SOD1(G93A) transgenic mice of amyotrophic lateral sclerosis.
Neuro-degenerative diseases
Wang Q,Zhang X,Chen S,Zhang X,Zhang S,Youdium M,Le W
Tue May 08 00:00:00 UTC 2012
Prevention of motor neuron degeneration by novel iron chelators in SOD1(G93A) transgenic mice of amyotrophic lateral sclerosis.
Neuro-degenerative diseases
Wang Q,Zhang X,Chen S,Zhang X,Zhang S,Youdium M,Le W
Tue May 08 00:00:00 UTC 2012
Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation.
Neuroscience letters
Ringman JM,Gylys KH,Medina LD,Fox M,Kepe V,Flores DL,Apostolova LG,Barrio JR,Small G,Silverman DH,Siu E,Cederbaum S,Hecimovic S,Malnar M,Chakraverty S,Goate AM,Bird TD,Leverenz JB
Mon Jan 10 00:00:00 UTC 2011
Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation.
Neuroscience letters
Ringman JM,Gylys KH,Medina LD,Fox M,Kepe V,Flores DL,Apostolova LG,Barrio JR,Small G,Silverman DH,Siu E,Cederbaum S,Hecimovic S,Malnar M,Chakraverty S,Goate AM,Bird TD,Leverenz JB
Mon Jan 10 00:00:00 UTC 2011
Proportional neuronal loss between the primary motor and sensory cortex in amyotrophic lateral sclerosis.
Neuroscience letters
Mochizuki Y,Mizutani T,Shimizu T,Kawata A
Mon Sep 26 00:00:00 UTC 2011
Proportional neuronal loss between the primary motor and sensory cortex in amyotrophic lateral sclerosis.
Neuroscience letters
Mochizuki Y,Mizutani T,Shimizu T,Kawata A
Mon Sep 26 00:00:00 UTC 2011
Immunohistochemical study of microscopic globular bodies of normal human brain.
Biomedical research (Tokyo, Japan)
Odagiri S,Mori F,Tanji K,Kuroda N,Wakabayashi K
Sat Oct 01 00:00:00 UTC 2011
Immunohistochemical study of microscopic globular bodies of normal human brain.
Biomedical research (Tokyo, Japan)
Odagiri S,Mori F,Tanji K,Kuroda N,Wakabayashi K
Sat Oct 01 00:00:00 UTC 2011
TDP-43 variants of frontotemporal lobar degeneration.
Journal of molecular neuroscience : MN
Bigio EH
Tue Nov 01 00:00:00 UTC 2011
TDP-43 variants of frontotemporal lobar degeneration.
Journal of molecular neuroscience : MN
Bigio EH
Tue Nov 01 00:00:00 UTC 2011
Novel progranulin mutation detected in 2 patients with FTLD.
Alzheimer disease and associated disorders
Skoglund L,Matsui T,Freeman SH,Wallin A,Blom ES,Frosch MP,Growdon JH,Hyman BT,Lannfelt L,Ingelsson M,Glaser A
Wed Oct 19 00:00:00 UTC 2011
Novel progranulin mutation detected in 2 patients with FTLD.
Alzheimer disease and associated disorders
Skoglund L,Matsui T,Freeman SH,Wallin A,Blom ES,Frosch MP,Growdon JH,Hyman BT,Lannfelt L,Ingelsson M,Glaser A
Wed Oct 19 00:00:00 UTC 2011
A morphometric study of the spatial patterns of TDP-43 immunoreactive neuronal inclusions in frontotemporal lobar degeneration (FTLD) with progranulin (GRN) mutation.
Histology and histopathology
Armstrong RA,Cairns NJ
Tue Feb 01 00:00:00 UTC 2011
A morphometric study of the spatial patterns of TDP-43 immunoreactive neuronal inclusions in frontotemporal lobar degeneration (FTLD) with progranulin (GRN) mutation.
Histology and histopathology
Armstrong RA,Cairns NJ
Tue Feb 01 00:00:00 UTC 2011
Semantic dementia with lower motor neuron disease showing FTLD-TDP type 3 pathology (sensu Mackenzie).
Neuropathology : official journal of the Japanese Society of Neuropathology
Östberg P,Bogdanović N
Wed Jun 01 00:00:00 UTC 2011
Semantic dementia with lower motor neuron disease showing FTLD-TDP type 3 pathology (sensu Mackenzie).
Neuropathology : official journal of the Japanese Society of Neuropathology
Östberg P,Bogdanović N
Wed Jun 01 00:00:00 UTC 2011
An autopsy case of an aged patient with spinocerebellar ataxia type 2.
Neuropathology : official journal of the Japanese Society of Neuropathology
Ishida C,Komai K,Yonezawa K,Sakajiri K,Nitta E,Kawashima A,Yamada M
Sat Oct 01 00:00:00 UTC 2011
An autopsy case of an aged patient with spinocerebellar ataxia type 2.
Neuropathology : official journal of the Japanese Society of Neuropathology
Ishida C,Komai K,Yonezawa K,Sakajiri K,Nitta E,Kawashima A,Yamada M
Sat Oct 01 00:00:00 UTC 2011
Enhancement of native and phosphorylated TDP-43 immunoreactivity by proteinase K treatment following autoclave heating.
Neuropathology : official journal of the Japanese Society of Neuropathology
Mori F,Tanji K,Kakita A,Takahashi H,Wakabayashi K
Mon Aug 01 00:00:00 UTC 2011
Enhancement of native and phosphorylated TDP-43 immunoreactivity by proteinase K treatment following autoclave heating.
Neuropathology : official journal of the Japanese Society of Neuropathology
Mori F,Tanji K,Kakita A,Takahashi H,Wakabayashi K
Mon Aug 01 00:00:00 UTC 2011
Ubiquitinated, p62 immunopositive cerebellar cortical neuronal inclusions are evident across the spectrum of TDP-43 proteinopathies but are only rarely additionally immunopositive for phosphorylation-dependent TDP-43.
Neuropathology : official journal of the Japanese Society of Neuropathology
King A,Maekawa S,Bodi I,Troakes C,Al-Sarraj S
Wed Jun 01 00:00:00 UTC 2011
Ubiquitinated, p62 immunopositive cerebellar cortical neuronal inclusions are evident across the spectrum of TDP-43 proteinopathies but are only rarely additionally immunopositive for phosphorylation-dependent TDP-43.
Neuropathology : official journal of the Japanese Society of Neuropathology
King A,Maekawa S,Bodi I,Troakes C,Al-Sarraj S
Wed Jun 01 00:00:00 UTC 2011
Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons.
PloS one
van Eersel J,Ke YD,Gladbach A,Bi M,Götz J,Kril JJ,Ittner LM
Tue Dec 06 00:00:00 UTC 2011
Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons.
PloS one
van Eersel J,Ke YD,Gladbach A,Bi M,Götz J,Kril JJ,Ittner LM
Tue Dec 06 00:00:00 UTC 2011
Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons.
PloS one
van Eersel J,Ke YD,Gladbach A,Bi M,Götz J,Kril JJ,Ittner LM
Tue Dec 06 00:00:00 UTC 2011
Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons.
PloS one
van Eersel J,Ke YD,Gladbach A,Bi M,Götz J,Kril JJ,Ittner LM
Tue Dec 06 00:00:00 UTC 2011
Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons.
PloS one
van Eersel J,Ke YD,Gladbach A,Bi M,Götz J,Kril JJ,Ittner LM
Tue Dec 06 00:00:00 UTC 2011
FUS and TARDBP but not SOD1 interact in genetic models of amyotrophic lateral sclerosis.
PLoS genetics
Kabashi E,Bercier V,Lissouba A,Liao M,Brustein E,Rouleau GA,Drapeau P
Mon Aug 01 00:00:00 UTC 2011
FUS and TARDBP but not SOD1 interact in genetic models of amyotrophic lateral sclerosis.
PLoS genetics
Kabashi E,Bercier V,Lissouba A,Liao M,Brustein E,Rouleau GA,Drapeau P
Mon Aug 01 00:00:00 UTC 2011
Proteomic analysis of hippocampal dentate granule cells in frontotemporal lobar degeneration: application of laser capture technology.
Frontiers in neurology
Gozal YM,Dammer EB,Duong DM,Cheng D,Gearing M,Rees HD,Peng J,Lah JJ,Levey AI
Thu Jul 14 00:00:00 UTC 2011
Proteomic analysis of hippocampal dentate granule cells in frontotemporal lobar degeneration: application of laser capture technology.
Frontiers in neurology
Gozal YM,Dammer EB,Duong DM,Cheng D,Gearing M,Rees HD,Peng J,Lah JJ,Levey AI
Thu Jul 14 00:00:00 UTC 2011
Elevated CSF TDP-43 levels in amyotrophic lateral sclerosis: specificity, sensitivity, and a possible prognostic value.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
Noto Y,Shibuya K,Sato Y,Kanai K,Misawa S,Sawai S,Mori M,Uchiyama T,Isose S,Nasu S,Sekiguchi Y,Fujimaki Y,Kasai T,Tokuda T,Nakagawa M,Kuwabara S
Tue Mar 01 00:00:00 UTC 2011
Elevated CSF TDP-43 levels in amyotrophic lateral sclerosis: specificity, sensitivity, and a possible prognostic value.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
Noto Y,Shibuya K,Sato Y,Kanai K,Misawa S,Sawai S,Mori M,Uchiyama T,Isose S,Nasu S,Sekiguchi Y,Fujimaki Y,Kasai T,Tokuda T,Nakagawa M,Kuwabara S
Tue Mar 01 00:00:00 UTC 2011
Sensory and motor neuronopathy in a patient with the A382P TDP-43 mutation.
Orphanet journal of rare diseases
Camdessanché JP,Belzil VV,Jousserand G,Rouleau GA,Créac'h C,Convers P,Antoine JC
Sat Feb 05 00:00:00 UTC 2011
Sensory and motor neuronopathy in a patient with the A382P TDP-43 mutation.
Orphanet journal of rare diseases
Camdessanché JP,Belzil VV,Jousserand G,Rouleau GA,Créac'h C,Convers P,Antoine JC
Sat Feb 05 00:00:00 UTC 2011
FTLD-TDP with motor neuron disease, visuospatial impairment and a progressive supranuclear palsy-like syndrome: broadening the clinical phenotype of TDP-43 proteinopathies. A report of three cases.
BMC neurology
Rusina R,Kovacs GG,Fiala J,Hort J,Ridzoň P,Holmerová I,Ströbel T,Matěj R
Tue May 10 00:00:00 UTC 2011
FTLD-TDP with motor neuron disease, visuospatial impairment and a progressive supranuclear palsy-like syndrome: broadening the clinical phenotype of TDP-43 proteinopathies. A report of three cases.
BMC neurology
Rusina R,Kovacs GG,Fiala J,Hort J,Ridzoň P,Holmerová I,Ströbel T,Matěj R
Tue May 10 00:00:00 UTC 2011
C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress.
Molecular neurodegeneration
Meyerowitz J,Parker SJ,Vella LJ,Ng DCh,Price KA,Liddell JR,Caragounis A,Li QX,Masters CL,Nonaka T,Hasegawa M,Bogoyevitch MA,Kanninen KM,Crouch PJ,White AR
Mon Aug 08 00:00:00 UTC 2011
C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress.
Molecular neurodegeneration
Meyerowitz J,Parker SJ,Vella LJ,Ng DCh,Price KA,Liddell JR,Caragounis A,Li QX,Masters CL,Nonaka T,Hasegawa M,Bogoyevitch MA,Kanninen KM,Crouch PJ,White AR
Mon Aug 08 00:00:00 UTC 2011
C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress.
Molecular neurodegeneration
Meyerowitz J,Parker SJ,Vella LJ,Ng DCh,Price KA,Liddell JR,Caragounis A,Li QX,Masters CL,Nonaka T,Hasegawa M,Bogoyevitch MA,Kanninen KM,Crouch PJ,White AR
Mon Aug 08 00:00:00 UTC 2011
C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress.
Molecular neurodegeneration
Meyerowitz J,Parker SJ,Vella LJ,Ng DCh,Price KA,Liddell JR,Caragounis A,Li QX,Masters CL,Nonaka T,Hasegawa M,Bogoyevitch MA,Kanninen KM,Crouch PJ,White AR
Mon Aug 08 00:00:00 UTC 2011
Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model.
The Journal of biological chemistry
Soon CPW,Donnelly PS,Turner BJ,Hung LW,Crouch PJ,Sherratt NA,Tan JL,Lim NK,Lam L,Bica L,Lim S,Hickey JL,Morizzi J,Powell A,Finkelstein DI,Culvenor JG,Masters CL,Duce J,White AR,Barnham KJ,Li QX
Fri Dec 23 00:00:00 UTC 2011
Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model.
The Journal of biological chemistry
Soon CPW,Donnelly PS,Turner BJ,Hung LW,Crouch PJ,Sherratt NA,Tan JL,Lim NK,Lam L,Bica L,Lim S,Hickey JL,Morizzi J,Powell A,Finkelstein DI,Culvenor JG,Masters CL,Duce J,White AR,Barnham KJ,Li QX
Fri Dec 23 00:00:00 UTC 2011
Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes.
The Journal of biological chemistry
Sephton CF,Cenik C,Kucukural A,Dammer EB,Cenik B,Han Y,Dewey CM,Roth FP,Herz J,Peng J,Moore MJ,Yu G
Fri Jan 14 00:00:00 UTC 2011
Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes.
The Journal of biological chemistry
Sephton CF,Cenik C,Kucukural A,Dammer EB,Cenik B,Han Y,Dewey CM,Roth FP,Herz J,Peng J,Moore MJ,Yu G
Fri Jan 14 00:00:00 UTC 2011
Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes.
The Journal of biological chemistry
Sephton CF,Cenik C,Kucukural A,Dammer EB,Cenik B,Han Y,Dewey CM,Roth FP,Herz J,Peng J,Moore MJ,Yu G
Fri Jan 14 00:00:00 UTC 2011
Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes.
The Journal of biological chemistry
Sephton CF,Cenik C,Kucukural A,Dammer EB,Cenik B,Han Y,Dewey CM,Roth FP,Herz J,Peng J,Moore MJ,Yu G
Fri Jan 14 00:00:00 UTC 2011
Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes.
The Journal of biological chemistry
Sephton CF,Cenik C,Kucukural A,Dammer EB,Cenik B,Han Y,Dewey CM,Roth FP,Herz J,Peng J,Moore MJ,Yu G
Fri Jan 14 00:00:00 UTC 2011
Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes.
The Journal of biological chemistry
Sephton CF,Cenik C,Kucukural A,Dammer EB,Cenik B,Han Y,Dewey CM,Roth FP,Herz J,Peng J,Moore MJ,Yu G
Fri Jan 14 00:00:00 UTC 2011
Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes.
The Journal of biological chemistry
Sephton CF,Cenik C,Kucukural A,Dammer EB,Cenik B,Han Y,Dewey CM,Roth FP,Herz J,Peng J,Moore MJ,Yu G
Fri Jan 14 00:00:00 UTC 2011
Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes.
The Journal of biological chemistry
Sephton CF,Cenik C,Kucukural A,Dammer EB,Cenik B,Han Y,Dewey CM,Roth FP,Herz J,Peng J,Moore MJ,Yu G
Fri Jan 14 00:00:00 UTC 2011
Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes.
The Journal of biological chemistry
Sephton CF,Cenik C,Kucukural A,Dammer EB,Cenik B,Han Y,Dewey CM,Roth FP,Herz J,Peng J,Moore MJ,Yu G
Fri Jan 14 00:00:00 UTC 2011
Molecular properties of TAR DNA binding protein-43 fragments are dependent upon its cleavage site.
Biochimica et biophysica acta
Furukawa Y,Kaneko K,Nukina N
Thu Dec 01 00:00:00 UTC 2011
Molecular properties of TAR DNA binding protein-43 fragments are dependent upon its cleavage site.
Biochimica et biophysica acta
Furukawa Y,Kaneko K,Nukina N
Thu Dec 01 00:00:00 UTC 2011
TDP-43-induced death is associated with altered regulation of BIM and Bcl-xL and attenuated by caspase-mediated TDP-43 cleavage.
The Journal of biological chemistry
Suzuki H,Lee K,Matsuoka M
Fri Apr 15 00:00:00 UTC 2011
TDP-43-induced death is associated with altered regulation of BIM and Bcl-xL and attenuated by caspase-mediated TDP-43 cleavage.
The Journal of biological chemistry
Suzuki H,Lee K,Matsuoka M
Fri Apr 15 00:00:00 UTC 2011
ApoE E4 is a susceptibility factor in amnestic but not aphasic dementias.
Alzheimer disease and associated disorders
Rogalski EJ,Rademaker A,Harrison TM,Helenowski I,Johnson N,Bigio E,Mishra M,Weintraub S,Mesulam MM
Wed Oct 19 00:00:00 UTC 2011
Diagnostic value of markers of muscle degeneration in sporadic inclusion body myositis.
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology
Dubourg O,Wanschitz J,Maisonobe T,Béhin A,Allenbach Y,Herson S,Benveniste O
Sat Oct 01 00:00:00 UTC 2011
Diagnostic value of markers of muscle degeneration in sporadic inclusion body myositis.
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology
Dubourg O,Wanschitz J,Maisonobe T,Béhin A,Allenbach Y,Herson S,Benveniste O
Sat Oct 01 00:00:00 UTC 2011
Differential involvement of optineurin in amyotrophic lateral sclerosis with or without SOD1 mutations.
Archives of neurology
Deng HX,Bigio EH,Zhai H,Fecto F,Ajroud K,Shi Y,Yan J,Mishra M,Ajroud-Driss S,Heller S,Sufit R,Siddique N,Mugnaini E,Siddique T
Mon Aug 01 00:00:00 UTC 2011
Differential involvement of optineurin in amyotrophic lateral sclerosis with or without SOD1 mutations.
Archives of neurology
Deng HX,Bigio EH,Zhai H,Fecto F,Ajroud K,Shi Y,Yan J,Mishra M,Ajroud-Driss S,Heller S,Sufit R,Siddique N,Mugnaini E,Siddique T
Mon Aug 01 00:00:00 UTC 2011
Differential involvement of optineurin in amyotrophic lateral sclerosis with or without SOD1 mutations.
Archives of neurology
Deng HX,Bigio EH,Zhai H,Fecto F,Ajroud K,Shi Y,Yan J,Mishra M,Ajroud-Driss S,Heller S,Sufit R,Siddique N,Mugnaini E,Siddique T
Mon Aug 01 00:00:00 UTC 2011
TDP-43 potentiates alpha-synuclein toxicity to dopaminergic neurons in transgenic mice.
International journal of biological sciences
Tian T,Huang C,Tong J,Yang M,Zhou H,Xia XG
Fri Mar 04 00:00:00 UTC 2011
TDP-43 potentiates alpha-synuclein toxicity to dopaminergic neurons in transgenic mice.
International journal of biological sciences
Tian T,Huang C,Tong J,Yang M,Zhou H,Xia XG
Fri Mar 04 00:00:00 UTC 2011
Overview and recent advances in neuropathology. Part 2: Neurodegeneration.
Pathology
Masters CL,Kril JJ,Halliday GM,Pamphlett R,Collins S,Hill AF,McLean C
Tue Feb 01 00:00:00 UTC 2011
TDP-43 knockdown impairs neurite outgrowth dependent on its target histone deacetylase 6.
Molecular neurodegeneration
Fiesel FC,Schurr C,Weber SS,Kahle PJ
Tue Aug 30 00:00:00 UTC 2011
TDP-43 knockdown impairs neurite outgrowth dependent on its target histone deacetylase 6.
Molecular neurodegeneration
Fiesel FC,Schurr C,Weber SS,Kahle PJ
Tue Aug 30 00:00:00 UTC 2011
Mutations of optineurin in amyotrophic lateral sclerosis.
Nature
Maruyama H,Morino H,Ito H,Izumi Y,Kato H,Watanabe Y,Kinoshita Y,Kamada M,Nodera H,Suzuki H,Komure O,Matsuura S,Kobatake K,Morimoto N,Abe K,Suzuki N,Aoki M,Kawata A,Hirai T,Kato T,Ogasawara K,Hirano A,Takumi T,Kusaka H,Hagiwara K,Kaji R,Kawakami H
Thu May 13 00:00:00 UTC 2010
Mutations of optineurin in amyotrophic lateral sclerosis.
Nature
Maruyama H,Morino H,Ito H,Izumi Y,Kato H,Watanabe Y,Kinoshita Y,Kamada M,Nodera H,Suzuki H,Komure O,Matsuura S,Kobatake K,Morimoto N,Abe K,Suzuki N,Aoki M,Kawata A,Hirai T,Kato T,Ogasawara K,Hirano A,Takumi T,Kusaka H,Hagiwara K,Kaji R,Kawakami H
Thu May 13 00:00:00 UTC 2010
Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS.
Nature
Elden AC,Kim HJ,Hart MP,Chen-Plotkin AS,Johnson BS,Fang X,Armakola M,Geser F,Greene R,Lu MM,Padmanabhan A,Clay-Falcone D,McCluskey L,Elman L,Juhr D,Gruber PJ,Rüb U,Auburger G,Trojanowski JQ,Lee VM,Van Deerlin VM,Bonini NM,Gitler AD
Thu Aug 26 00:00:00 UTC 2010
Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS.
Nature
Elden AC,Kim HJ,Hart MP,Chen-Plotkin AS,Johnson BS,Fang X,Armakola M,Geser F,Greene R,Lu MM,Padmanabhan A,Clay-Falcone D,McCluskey L,Elman L,Juhr D,Gruber PJ,Rüb U,Auburger G,Trojanowski JQ,Lee VM,Van Deerlin VM,Bonini NM,Gitler AD
Thu Aug 26 00:00:00 UTC 2010
Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS.
Nature
Elden AC,Kim HJ,Hart MP,Chen-Plotkin AS,Johnson BS,Fang X,Armakola M,Geser F,Greene R,Lu MM,Padmanabhan A,Clay-Falcone D,McCluskey L,Elman L,Juhr D,Gruber PJ,Rüb U,Auburger G,Trojanowski JQ,Lee VM,Van Deerlin VM,Bonini NM,Gitler AD
Thu Aug 26 00:00:00 UTC 2010
Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS.
Nature
Elden AC,Kim HJ,Hart MP,Chen-Plotkin AS,Johnson BS,Fang X,Armakola M,Geser F,Greene R,Lu MM,Padmanabhan A,Clay-Falcone D,McCluskey L,Elman L,Juhr D,Gruber PJ,Rüb U,Auburger G,Trojanowski JQ,Lee VM,Van Deerlin VM,Bonini NM,Gitler AD
Thu Aug 26 00:00:00 UTC 2010
Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS.
Nature
Elden AC,Kim HJ,Hart MP,Chen-Plotkin AS,Johnson BS,Fang X,Armakola M,Geser F,Greene R,Lu MM,Padmanabhan A,Clay-Falcone D,McCluskey L,Elman L,Juhr D,Gruber PJ,Rüb U,Auburger G,Trojanowski JQ,Lee VM,Van Deerlin VM,Bonini NM,Gitler AD
Thu Aug 26 00:00:00 UTC 2010
Efficient conditional and promoter-specific in vivo expression of cDNAs of choice by taking advantage of recombinase-mediated cassette exchange using FlEx gene traps.
Nucleic acids research
Schebelle L,Wolf C,Stribl C,Javaheri T,Schnütgen F,Ettinger A,Ivics Z,Hansen J,Ruiz P,von Melchner H,Wurst W,Floss T
Sat May 01 00:00:00 UTC 2010
Efficient conditional and promoter-specific in vivo expression of cDNAs of choice by taking advantage of recombinase-mediated cassette exchange using FlEx gene traps.
Nucleic acids research
Schebelle L,Wolf C,Stribl C,Javaheri T,Schnütgen F,Ettinger A,Ivics Z,Hansen J,Ruiz P,von Melchner H,Wurst W,Floss T
Sat May 01 00:00:00 UTC 2010
Exome sequencing reveals VCP mutations as a cause of familial ALS.
Neuron
Johnson JO,Mandrioli J,Benatar M,Abramzon Y,Van Deerlin VM,Trojanowski JQ,Gibbs JR,Brunetti M,Gronka S,Wuu J,Ding J,McCluskey L,Martinez-Lage M,Falcone D,Hernandez DG,Arepalli S,Chong S,Schymick JC,Rothstein J,Landi F,Wang YD,Calvo A,Mora G,Sabatelli M,Monsurrò MR,Battistini S,Salvi F,Spataro R,Sola P,Borghero G,Galassi G,Scholz SW,Taylor JP,Restagno G,Chiò A,Traynor BJ
Thu Dec 09 00:00:00 UTC 2010
Exome sequencing reveals VCP mutations as a cause of familial ALS.
Neuron
Johnson JO,Mandrioli J,Benatar M,Abramzon Y,Van Deerlin VM,Trojanowski JQ,Gibbs JR,Brunetti M,Gronka S,Wuu J,Ding J,McCluskey L,Martinez-Lage M,Falcone D,Hernandez DG,Arepalli S,Chong S,Schymick JC,Rothstein J,Landi F,Wang YD,Calvo A,Mora G,Sabatelli M,Monsurrò MR,Battistini S,Salvi F,Spataro R,Sola P,Borghero G,Galassi G,Scholz SW,Taylor JP,Restagno G,Chiò A,Traynor BJ
Thu Dec 09 00:00:00 UTC 2010
Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U.
The Journal of experimental medicine
Tsai KJ,Yang CH,Fang YH,Cho KH,Chien WL,Wang WT,Wu TW,Lin CP,Fu WM,Shen CK
Mon Aug 02 00:00:00 UTC 2010
Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U.
The Journal of experimental medicine
Tsai KJ,Yang CH,Fang YH,Cho KH,Chien WL,Wang WT,Wu TW,Lin CP,Fu WM,Shen CK
Mon Aug 02 00:00:00 UTC 2010
Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U.
The Journal of experimental medicine
Tsai KJ,Yang CH,Fang YH,Cho KH,Chien WL,Wang WT,Wu TW,Lin CP,Fu WM,Shen CK
Mon Aug 02 00:00:00 UTC 2010
Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U.
The Journal of experimental medicine
Tsai KJ,Yang CH,Fang YH,Cho KH,Chien WL,Wang WT,Wu TW,Lin CP,Fu WM,Shen CK
Mon Aug 02 00:00:00 UTC 2010
Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U.
The Journal of experimental medicine
Tsai KJ,Yang CH,Fang YH,Cho KH,Chien WL,Wang WT,Wu TW,Lin CP,Fu WM,Shen CK
Mon Aug 02 00:00:00 UTC 2010
Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice.
The Journal of experimental medicine
Yin F,Banerjee R,Thomas B,Zhou P,Qian L,Jia T,Ma X,Ma Y,Iadecola C,Beal MF,Nathan C,Ding A
Mon Jan 18 00:00:00 UTC 2010
Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice.
The Journal of experimental medicine
Yin F,Banerjee R,Thomas B,Zhou P,Qian L,Jia T,Ma X,Ma Y,Iadecola C,Beal MF,Nathan C,Ding A
Mon Jan 18 00:00:00 UTC 2010
Involvement of Onuf's nucleus in Machado-Joseph disease: a morphometric and immunohistochemical study.
Acta neuropathologica
Shimizu H,Yamada M,Toyoshima Y,Ikeuchi T,Onodera O,Takahashi H
Fri Oct 01 00:00:00 UTC 2010
Involvement of Onuf's nucleus in Machado-Joseph disease: a morphometric and immunohistochemical study.
Acta neuropathologica
Shimizu H,Yamada M,Toyoshima Y,Ikeuchi T,Onodera O,Takahashi H
Fri Oct 01 00:00:00 UTC 2010
Involvement of Onuf's nucleus in Machado-Joseph disease: a morphometric and immunohistochemical study.
Acta neuropathologica
Shimizu H,Yamada M,Toyoshima Y,Ikeuchi T,Onodera O,Takahashi H
Fri Oct 01 00:00:00 UTC 2010
Sporadic corticobasal syndrome due to FTLD-TDP.
Acta neuropathologica
Tartaglia MC,Sidhu M,Laluz V,Racine C,Rabinovici GD,Creighton K,Karydas A,Rademakers R,Huang EJ,Miller BL,DeArmond SJ,Seeley WW
Mon Mar 01 00:00:00 UTC 2010
Sporadic corticobasal syndrome due to FTLD-TDP.
Acta neuropathologica
Tartaglia MC,Sidhu M,Laluz V,Racine C,Rabinovici GD,Creighton K,Karydas A,Rademakers R,Huang EJ,Miller BL,DeArmond SJ,Seeley WW
Mon Mar 01 00:00:00 UTC 2010
TDP-43 pathology in primary progressive aphasia and frontotemporal dementia with pathologic Alzheimer disease.
Acta neuropathologica
Bigio EH,Mishra M,Hatanpaa KJ,White CL,Johnson N,Rademaker A,Weitner BB,Deng HX,Dubner SD,Weintraub S,Mesulam M
Thu Jul 01 00:00:00 UTC 2010
TDP-43 pathology in primary progressive aphasia and frontotemporal dementia with pathologic Alzheimer disease.
Acta neuropathologica
Bigio EH,Mishra M,Hatanpaa KJ,White CL,Johnson N,Rademaker A,Weitner BB,Deng HX,Dubner SD,Weintraub S,Mesulam M
Thu Jul 01 00:00:00 UTC 2010
Brain progranulin expression in GRN-associated frontotemporal lobar degeneration.
Acta neuropathologica
Chen-Plotkin AS,Xiao J,Geser F,Martinez-Lage M,Grossman M,Unger T,Wood EM,Van Deerlin VM,Trojanowski JQ,Lee VM
Fri Jan 01 00:00:00 UTC 2010
Brain progranulin expression in GRN-associated frontotemporal lobar degeneration.
Acta neuropathologica
Chen-Plotkin AS,Xiao J,Geser F,Martinez-Lage M,Grossman M,Unger T,Wood EM,Van Deerlin VM,Trojanowski JQ,Lee VM
Fri Jan 01 00:00:00 UTC 2010
Age-related motor neuron degeneration in DNA repair-deficient Ercc1 mice.
Acta neuropathologica
de Waard MC,van der Pluijm I,Zuiderveen Borgesius N,Comley LH,Haasdijk ED,Rijksen Y,Ridwan Y,Zondag G,Hoeijmakers JH,Elgersma Y,Gillingwater TH,Jaarsma D
Fri Oct 01 00:00:00 UTC 2010
Age-related motor neuron degeneration in DNA repair-deficient Ercc1 mice.
Acta neuropathologica
de Waard MC,van der Pluijm I,Zuiderveen Borgesius N,Comley LH,Haasdijk ED,Rijksen Y,Ridwan Y,Zondag G,Hoeijmakers JH,Elgersma Y,Gillingwater TH,Jaarsma D
Fri Oct 01 00:00:00 UTC 2010
TDP-43 pathology in sporadic ALS occurs in motor neurons lacking the RNA editing enzyme ADAR2.
Acta neuropathologica
Aizawa H,Sawada J,Hideyama T,Yamashita T,Katayama T,Hasebe N,Kimura T,Yahara O,Kwak S
Thu Jul 01 00:00:00 UTC 2010
TDP-43 pathology in sporadic ALS occurs in motor neurons lacking the RNA editing enzyme ADAR2.
Acta neuropathologica
Aizawa H,Sawada J,Hideyama T,Yamashita T,Katayama T,Hasebe N,Kimura T,Yahara O,Kwak S
Thu Jul 01 00:00:00 UTC 2010
Nuclear import impairment causes cytoplasmic trans-activation response DNA-binding protein accumulation and is associated with frontotemporal lobar degeneration.
Brain : a journal of neurology
Nishimura AL,Zupunski V,Troakes C,Kathe C,Fratta P,Howell M,Gallo JM,Hortobágyi T,Shaw CE,Rogelj B
Tue Jun 01 00:00:00 UTC 2010
Nuclear import impairment causes cytoplasmic trans-activation response DNA-binding protein accumulation and is associated with frontotemporal lobar degeneration.
Brain : a journal of neurology
Nishimura AL,Zupunski V,Troakes C,Kathe C,Fratta P,Howell M,Gallo JM,Hortobágyi T,Shaw CE,Rogelj B
Tue Jun 01 00:00:00 UTC 2010
Nuclear import impairment causes cytoplasmic trans-activation response DNA-binding protein accumulation and is associated with frontotemporal lobar degeneration.
Brain : a journal of neurology
Nishimura AL,Zupunski V,Troakes C,Kathe C,Fratta P,Howell M,Gallo JM,Hortobágyi T,Shaw CE,Rogelj B
Tue Jun 01 00:00:00 UTC 2010
Nuclear import impairment causes cytoplasmic trans-activation response DNA-binding protein accumulation and is associated with frontotemporal lobar degeneration.
Brain : a journal of neurology
Nishimura AL,Zupunski V,Troakes C,Kathe C,Fratta P,Howell M,Gallo JM,Hortobágyi T,Shaw CE,Rogelj B
Tue Jun 01 00:00:00 UTC 2010
A mutation affecting the sodium/proton exchanger, SLC9A6, causes mental retardation with tau deposition.
Brain : a journal of neurology
Garbern JY,Neumann M,Trojanowski JQ,Lee VM,Feldman G,Norris JW,Friez MJ,Schwartz CE,Stevenson R,Sima AA
Sat May 01 00:00:00 UTC 2010
A mutation affecting the sodium/proton exchanger, SLC9A6, causes mental retardation with tau deposition.
Brain : a journal of neurology
Garbern JY,Neumann M,Trojanowski JQ,Lee VM,Feldman G,Norris JW,Friez MJ,Schwartz CE,Stevenson R,Sima AA
Sat May 01 00:00:00 UTC 2010
Very early-onset frontotemporal dementia with no family history predicts underlying fused in sarcoma pathology.
Brain : a journal of neurology
Loy CT,McCusker E,Kril JJ,Kwok JB,Brooks WS,McCann H,Isaacs AM,Halliday GM
Wed Dec 01 00:00:00 UTC 2010
Very early-onset frontotemporal dementia with no family history predicts underlying fused in sarcoma pathology.
Brain : a journal of neurology
Loy CT,McCusker E,Kril JJ,Kwok JB,Brooks WS,McCann H,Isaacs AM,Halliday GM
Wed Dec 01 00:00:00 UTC 2010
Alzheimer's disease phenotypes and genotypes associated with mutations in presenilin 2.
Brain : a journal of neurology
Jayadev S,Leverenz JB,Steinbart E,Stahl J,Klunk W,Yu CE,Bird TD
Thu Apr 01 00:00:00 UTC 2010
Alzheimer's disease phenotypes and genotypes associated with mutations in presenilin 2.
Brain : a journal of neurology
Jayadev S,Leverenz JB,Steinbart E,Stahl J,Klunk W,Yu CE,Bird TD
Thu Apr 01 00:00:00 UTC 2010
Semantic dementia: demography, familial factors and survival in a consecutive series of 100 cases.
Brain : a journal of neurology
Hodges JR,Mitchell J,Dawson K,Spillantini MG,Xuereb JH,McMonagle P,Nestor PJ,Patterson K
Fri Jan 01 00:00:00 UTC 2010
Semantic dementia: demography, familial factors and survival in a consecutive series of 100 cases.
Brain : a journal of neurology
Hodges JR,Mitchell J,Dawson K,Spillantini MG,Xuereb JH,McMonagle P,Nestor PJ,Patterson K
Fri Jan 01 00:00:00 UTC 2010
Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6.
The EMBO journal
Fiesel FC,Voigt A,Weber SS,Van den Haute C,Waldenmaier A,Görner K,Walter M,Anderson ML,Kern JV,Rasse TM,Schmidt T,Springer W,Kirchner R,Bonin M,Neumann M,Baekelandt V,Alunni-Fabbroni M,Schulz JB,Kahle PJ
Wed Jan 06 00:00:00 UTC 2010
Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6.
The EMBO journal
Fiesel FC,Voigt A,Weber SS,Van den Haute C,Waldenmaier A,Görner K,Walter M,Anderson ML,Kern JV,Rasse TM,Schmidt T,Springer W,Kirchner R,Bonin M,Neumann M,Baekelandt V,Alunni-Fabbroni M,Schulz JB,Kahle PJ
Wed Jan 06 00:00:00 UTC 2010
FUS mutations in amyotrophic lateral sclerosis: clinical, pathological, neurophysiological and genetic analysis.
Journal of neurology, neurosurgery, and psychiatry
Blair IP,Williams KL,Warraich ST,Durnall JC,Thoeng AD,Manavis J,Blumbergs PC,Vucic S,Kiernan MC,Nicholson GA
Tue Jun 01 00:00:00 UTC 2010
FUS mutations in amyotrophic lateral sclerosis: clinical, pathological, neurophysiological and genetic analysis.
Journal of neurology, neurosurgery, and psychiatry
Blair IP,Williams KL,Warraich ST,Durnall JC,Thoeng AD,Manavis J,Blumbergs PC,Vucic S,Kiernan MC,Nicholson GA
Tue Jun 01 00:00:00 UTC 2010
Survival in progressive supranuclear palsy and frontotemporal dementia.
Journal of neurology, neurosurgery, and psychiatry
Chiu WZ,Kaat LD,Seelaar H,Rosso SM,Boon AJ,Kamphorst W,van Swieten JC
Thu Apr 01 00:00:00 UTC 2010
Survival in progressive supranuclear palsy and frontotemporal dementia.
Journal of neurology, neurosurgery, and psychiatry
Chiu WZ,Kaat LD,Seelaar H,Rosso SM,Boon AJ,Kamphorst W,van Swieten JC
Thu Apr 01 00:00:00 UTC 2010
Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America
Shan X,Chiang PM,Price DL,Wong PC
Tue Sep 14 00:00:00 UTC 2010
Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America
Shan X,Chiang PM,Price DL,Wong PC
Tue Sep 14 00:00:00 UTC 2010
Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America
Shan X,Chiang PM,Price DL,Wong PC
Tue Sep 14 00:00:00 UTC 2010
Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America
Shan X,Chiang PM,Price DL,Wong PC
Tue Sep 14 00:00:00 UTC 2010
Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism.
Proceedings of the National Academy of Sciences of the United States of America
Chiang PM,Ling J,Jeong YH,Price DL,Aja SM,Wong PC
Tue Sep 14 00:00:00 UTC 2010
Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism.
Proceedings of the National Academy of Sciences of the United States of America
Chiang PM,Ling J,Jeong YH,Price DL,Aja SM,Wong PC
Tue Sep 14 00:00:00 UTC 2010
Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase.
Proceedings of the National Academy of Sciences of the United States of America
Mitchell J,Paul P,Chen HJ,Morris A,Payling M,Falchi M,Habgood J,Panoutsou S,Winkler S,Tisato V,Hajitou A,Smith B,Vance C,Shaw C,Mazarakis ND,de Belleroche J
Tue Apr 20 00:00:00 UTC 2010
Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase.
Proceedings of the National Academy of Sciences of the United States of America
Mitchell J,Paul P,Chen HJ,Morris A,Payling M,Falchi M,Habgood J,Panoutsou S,Winkler S,Tisato V,Hajitou A,Smith B,Vance C,Shaw C,Mazarakis ND,de Belleroche J
Tue Apr 20 00:00:00 UTC 2010
TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration.
Proceedings of the National Academy of Sciences of the United States of America
Wils H,Kleinberger G,Janssens J,Pereson S,Joris G,Cuijt I,Smits V,Ceuterick-de Groote C,Van Broeckhoven C,Kumar-Singh S
Tue Feb 23 00:00:00 UTC 2010
TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration.
Proceedings of the National Academy of Sciences of the United States of America
Wils H,Kleinberger G,Janssens J,Pereson S,Joris G,Cuijt I,Smits V,Ceuterick-de Groote C,Van Broeckhoven C,Kumar-Singh S
Tue Feb 23 00:00:00 UTC 2010
ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.
Proceedings of the National Academy of Sciences of the United States of America
Ling SC,Albuquerque CP,Han JS,Lagier-Tourenne C,Tokunaga S,Zhou H,Cleveland DW
Tue Jul 27 00:00:00 UTC 2010
ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.
Proceedings of the National Academy of Sciences of the United States of America
Ling SC,Albuquerque CP,Han JS,Lagier-Tourenne C,Tokunaga S,Zhou H,Cleveland DW
Tue Jul 27 00:00:00 UTC 2010
ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.
Proceedings of the National Academy of Sciences of the United States of America
Ling SC,Albuquerque CP,Han JS,Lagier-Tourenne C,Tokunaga S,Zhou H,Cleveland DW
Tue Jul 27 00:00:00 UTC 2010
ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.
Proceedings of the National Academy of Sciences of the United States of America
Ling SC,Albuquerque CP,Han JS,Lagier-Tourenne C,Tokunaga S,Zhou H,Cleveland DW
Tue Jul 27 00:00:00 UTC 2010
Does TDP-43 type confer a distinct pattern of atrophy in frontotemporal lobar degeneration?
Neurology
Whitwell JL,Jack CR,Parisi JE,Senjem ML,Knopman DS,Boeve BF,Rademakers R,Baker M,Petersen RC,Dickson DW,Josephs KA
Tue Dec 14 00:00:00 UTC 2010
Does TDP-43 type confer a distinct pattern of atrophy in frontotemporal lobar degeneration?
Neurology
Whitwell JL,Jack CR,Parisi JE,Senjem ML,Knopman DS,Boeve BF,Rademakers R,Baker M,Petersen RC,Dickson DW,Josephs KA
Tue Dec 14 00:00:00 UTC 2010
In vivo amyloid imaging in autopsy-confirmed Parkinson disease with dementia.
Neurology
Burack MA,Hartlein J,Flores HP,Taylor-Reinwald L,Perlmutter JS,Cairns NJ
Tue Jan 05 00:00:00 UTC 2010
In vivo amyloid imaging in autopsy-confirmed Parkinson disease with dementia.
Neurology
Burack MA,Hartlein J,Flores HP,Taylor-Reinwald L,Perlmutter JS,Cairns NJ
Tue Jan 05 00:00:00 UTC 2010
TDP-43 subtypes are associated with distinct atrophy patterns in frontotemporal dementia.
Neurology
Rohrer JD,Geser F,Zhou J,Gennatas ED,Sidhu M,Trojanowski JQ,Dearmond SJ,Miller BL,Seeley WW
Tue Dec 14 00:00:00 UTC 2010
TDP-43 subtypes are associated with distinct atrophy patterns in frontotemporal dementia.
Neurology
Rohrer JD,Geser F,Zhou J,Gennatas ED,Sidhu M,Trojanowski JQ,Dearmond SJ,Miller BL,Seeley WW
Tue Dec 14 00:00:00 UTC 2010
Juvenile ALS with basophilic inclusions is a FUS proteinopathy with FUS mutations.
Neurology
Bäumer D,Hilton D,Paine SM,Turner MR,Lowe J,Talbot K,Ansorge O
Tue Aug 17 00:00:00 UTC 2010
Juvenile ALS with basophilic inclusions is a FUS proteinopathy with FUS mutations.
Neurology
Bäumer D,Hilton D,Paine SM,Turner MR,Lowe J,Talbot K,Ansorge O
Tue Aug 17 00:00:00 UTC 2010
FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis.
Annals of neurology
Deng HX,Zhai H,Bigio EH,Yan J,Fecto F,Ajroud K,Mishra M,Ajroud-Driss S,Heller S,Sufit R,Siddique N,Mugnaini E,Siddique T
Tue Jun 01 00:00:00 UTC 2010
FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis.
Annals of neurology
Deng HX,Zhai H,Bigio EH,Yan J,Fecto F,Ajroud K,Mishra M,Ajroud-Driss S,Heller S,Sufit R,Siddique N,Mugnaini E,Siddique T
Tue Jun 01 00:00:00 UTC 2010
FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis.
Annals of neurology
Deng HX,Zhai H,Bigio EH,Yan J,Fecto F,Ajroud K,Mishra M,Ajroud-Driss S,Heller S,Sufit R,Siddique N,Mugnaini E,Siddique T
Tue Jun 01 00:00:00 UTC 2010
FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis.
Annals of neurology
Deng HX,Zhai H,Bigio EH,Yan J,Fecto F,Ajroud K,Mishra M,Ajroud-Driss S,Heller S,Sufit R,Siddique N,Mugnaini E,Siddique T
Tue Jun 01 00:00:00 UTC 2010
Olfactory epithelium amyloid-beta and paired helical filament-tau pathology in Alzheimer disease.
Annals of neurology
Arnold SE,Lee EB,Moberg PJ,Stutzbach L,Kazi H,Han LY,Lee VM,Trojanowski JQ
Thu Apr 01 00:00:00 UTC 2010
Olfactory epithelium amyloid-beta and paired helical filament-tau pathology in Alzheimer disease.
Annals of neurology
Arnold SE,Lee EB,Moberg PJ,Stutzbach L,Kazi H,Han LY,Lee VM,Trojanowski JQ
Thu Apr 01 00:00:00 UTC 2010
Lack of shunt response in suspected idiopathic normal pressure hydrocephalus with Alzheimer disease pathology.
Annals of neurology
Hamilton R,Patel S,Lee EB,Jackson EM,Lopinto J,Arnold SE,Clark CM,Basil A,Shaw LM,Xie SX,Grady MS,Trojanowski JQ
Fri Oct 01 00:00:00 UTC 2010
Lack of shunt response in suspected idiopathic normal pressure hydrocephalus with Alzheimer disease pathology.
Annals of neurology
Hamilton R,Patel S,Lee EB,Jackson EM,Lopinto J,Arnold SE,Clark CM,Basil A,Shaw LM,Xie SX,Grady MS,Trojanowski JQ
Fri Oct 01 00:00:00 UTC 2010
Sigma nonopioid intracellular receptor 1 mutations cause frontotemporal lobar degeneration-motor neuron disease.
Annals of neurology
Luty AA,Kwok JB,Dobson-Stone C,Loy CT,Coupland KG,Karlström H,Sobow T,Tchorzewska J,Maruszak A,Barcikowska M,Panegyres PK,Zekanowski C,Brooks WS,Williams KL,Blair IP,Mather KA,Sachdev PS,Halliday GM,Schofield PR
Mon Nov 01 00:00:00 UTC 2010
Sigma nonopioid intracellular receptor 1 mutations cause frontotemporal lobar degeneration-motor neuron disease.
Annals of neurology
Luty AA,Kwok JB,Dobson-Stone C,Loy CT,Coupland KG,Karlström H,Sobow T,Tchorzewska J,Maruszak A,Barcikowska M,Panegyres PK,Zekanowski C,Brooks WS,Williams KL,Blair IP,Mather KA,Sachdev PS,Halliday GM,Schofield PR
Mon Nov 01 00:00:00 UTC 2010
Sigma nonopioid intracellular receptor 1 mutations cause frontotemporal lobar degeneration-motor neuron disease.
Annals of neurology
Luty AA,Kwok JB,Dobson-Stone C,Loy CT,Coupland KG,Karlström H,Sobow T,Tchorzewska J,Maruszak A,Barcikowska M,Panegyres PK,Zekanowski C,Brooks WS,Williams KL,Blair IP,Mather KA,Sachdev PS,Halliday GM,Schofield PR
Mon Nov 01 00:00:00 UTC 2010
Sigma nonopioid intracellular receptor 1 mutations cause frontotemporal lobar degeneration-motor neuron disease.
Annals of neurology
Luty AA,Kwok JB,Dobson-Stone C,Loy CT,Coupland KG,Karlström H,Sobow T,Tchorzewska J,Maruszak A,Barcikowska M,Panegyres PK,Zekanowski C,Brooks WS,Williams KL,Blair IP,Mather KA,Sachdev PS,Halliday GM,Schofield PR
Mon Nov 01 00:00:00 UTC 2010
Anatomical differences between CBS-corticobasal degeneration and CBS-Alzheimer's disease.
Movement disorders : official journal of the Movement Disorder Society
Josephs KA,Whitwell JL,Boeve BF,Knopman DS,Petersen RC,Hu WT,Parisi JE,Dickson DW,Jack CR
Thu Jul 15 00:00:00 UTC 2010
Anatomical differences between CBS-corticobasal degeneration and CBS-Alzheimer's disease.
Movement disorders : official journal of the Movement Disorder Society
Josephs KA,Whitwell JL,Boeve BF,Knopman DS,Petersen RC,Hu WT,Parisi JE,Dickson DW,Jack CR
Thu Jul 15 00:00:00 UTC 2010
A novel X-linked four-repeat tauopathy with Parkinsonism and spasticity.
Movement disorders : official journal of the Movement Disorder Society
Poorkaj P,Raskind WH,Leverenz JB,Matsushita M,Zabetian CP,Samii A,Kim S,Gazi N,Nutt JG,Wolff J,Yearout D,Greenup JL,Steinbart EJ,Bird TD
Fri Jul 30 00:00:00 UTC 2010
A novel X-linked four-repeat tauopathy with Parkinsonism and spasticity.
Movement disorders : official journal of the Movement Disorder Society
Poorkaj P,Raskind WH,Leverenz JB,Matsushita M,Zabetian CP,Samii A,Kim S,Gazi N,Nutt JG,Wolff J,Yearout D,Greenup JL,Steinbart EJ,Bird TD
Fri Jul 30 00:00:00 UTC 2010
Modeling the association between 43 different clinical and pathological variables and the severity of cognitive impairment in a large autopsy cohort of elderly persons.
Brain pathology (Zurich, Switzerland)
Nelson PT,Abner EL,Schmitt FA,Kryscio RJ,Jicha GA,Smith CD,Davis DG,Poduska JW,Patel E,Mendiondo MS,Markesbery WR
Fri Jan 01 00:00:00 UTC 2010
Modeling the association between 43 different clinical and pathological variables and the severity of cognitive impairment in a large autopsy cohort of elderly persons.
Brain pathology (Zurich, Switzerland)
Nelson PT,Abner EL,Schmitt FA,Kryscio RJ,Jicha GA,Smith CD,Davis DG,Poduska JW,Patel E,Mendiondo MS,Markesbery WR
Fri Jan 01 00:00:00 UTC 2010
FUS-immunoreactive intranuclear inclusions in neurodegenerative disease.
Brain pathology (Zurich, Switzerland)
Woulfe J,Gray DA,Mackenzie IR
Sat May 01 00:00:00 UTC 2010
FUS-immunoreactive intranuclear inclusions in neurodegenerative disease.
Brain pathology (Zurich, Switzerland)
Woulfe J,Gray DA,Mackenzie IR
Sat May 01 00:00:00 UTC 2010
Extensive FUS-immunoreactive pathology in juvenile amyotrophic lateral sclerosis with basophilic inclusions.
Brain pathology (Zurich, Switzerland)
Huang EJ,Zhang J,Geser F,Trojanowski JQ,Strober JB,Dickson DW,Brown RH,Shapiro BE,Lomen-Hoerth C
Mon Nov 01 00:00:00 UTC 2010
Extensive FUS-immunoreactive pathology in juvenile amyotrophic lateral sclerosis with basophilic inclusions.
Brain pathology (Zurich, Switzerland)
Huang EJ,Zhang J,Geser F,Trojanowski JQ,Strober JB,Dickson DW,Brown RH,Shapiro BE,Lomen-Hoerth C
Mon Nov 01 00:00:00 UTC 2010
Neuropathology of olfactory ensheathing cell transplantation into the brain of two amyotrophic lateral sclerosis (ALS) patients.
Brain pathology (Zurich, Switzerland)
Giordana MT,Grifoni S,Votta B,Magistrello M,Vercellino M,Pellerino A,Navone R,Valentini C,Calvo A,Chiò A
Thu Jul 01 00:00:00 UTC 2010
Neuropathology of olfactory ensheathing cell transplantation into the brain of two amyotrophic lateral sclerosis (ALS) patients.
Brain pathology (Zurich, Switzerland)
Giordana MT,Grifoni S,Votta B,Magistrello M,Vercellino M,Pellerino A,Navone R,Valentini C,Calvo A,Chiò A
Thu Jul 01 00:00:00 UTC 2010
TDP-43 redistribution is an early event in sporadic amyotrophic lateral sclerosis.
Brain pathology (Zurich, Switzerland)
Giordana MT,Piccinini M,Grifoni S,De Marco G,Vercellino M,Magistrello M,Pellerino A,Buccinnà B,Lupino E,Rinaudo MT
Mon Mar 01 00:00:00 UTC 2010
TDP-43 redistribution is an early event in sporadic amyotrophic lateral sclerosis.
Brain pathology (Zurich, Switzerland)
Giordana MT,Piccinini M,Grifoni S,De Marco G,Vercellino M,Magistrello M,Pellerino A,Buccinnà B,Lupino E,Rinaudo MT
Mon Mar 01 00:00:00 UTC 2010
TDP-43 redistribution is an early event in sporadic amyotrophic lateral sclerosis.
Brain pathology (Zurich, Switzerland)
Giordana MT,Piccinini M,Grifoni S,De Marco G,Vercellino M,Magistrello M,Pellerino A,Buccinnà B,Lupino E,Rinaudo MT
Mon Mar 01 00:00:00 UTC 2010
TDP-43 redistribution is an early event in sporadic amyotrophic lateral sclerosis.
Brain pathology (Zurich, Switzerland)
Giordana MT,Piccinini M,Grifoni S,De Marco G,Vercellino M,Magistrello M,Pellerino A,Buccinnà B,Lupino E,Rinaudo MT
Mon Mar 01 00:00:00 UTC 2010
TDP-43 redistribution is an early event in sporadic amyotrophic lateral sclerosis.
Brain pathology (Zurich, Switzerland)
Giordana MT,Piccinini M,Grifoni S,De Marco G,Vercellino M,Magistrello M,Pellerino A,Buccinnà B,Lupino E,Rinaudo MT
Mon Mar 01 00:00:00 UTC 2010
Cytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Barmada SJ,Skibinski G,Korb E,Rao EJ,Wu JY,Finkbeiner S
Wed Jan 13 00:00:00 UTC 2010
Cytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Barmada SJ,Skibinski G,Korb E,Rao EJ,Wu JY,Finkbeiner S
Wed Jan 13 00:00:00 UTC 2010
Cytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Barmada SJ,Skibinski G,Korb E,Rao EJ,Wu JY,Finkbeiner S
Wed Jan 13 00:00:00 UTC 2010
Cytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Barmada SJ,Skibinski G,Korb E,Rao EJ,Wu JY,Finkbeiner S
Wed Jan 13 00:00:00 UTC 2010
TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ritson GP,Custer SK,Freibaum BD,Guinto JB,Geffel D,Moore J,Tang W,Winton MJ,Neumann M,Trojanowski JQ,Lee VM,Forman MS,Taylor JP
Wed Jun 02 00:00:00 UTC 2010
TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ritson GP,Custer SK,Freibaum BD,Guinto JB,Geffel D,Moore J,Tang W,Winton MJ,Neumann M,Trojanowski JQ,Lee VM,Forman MS,Taylor JP
Wed Jun 02 00:00:00 UTC 2010
TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ritson GP,Custer SK,Freibaum BD,Guinto JB,Geffel D,Moore J,Tang W,Winton MJ,Neumann M,Trojanowski JQ,Lee VM,Forman MS,Taylor JP
Wed Jun 02 00:00:00 UTC 2010
TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ritson GP,Custer SK,Freibaum BD,Guinto JB,Geffel D,Moore J,Tang W,Winton MJ,Neumann M,Trojanowski JQ,Lee VM,Forman MS,Taylor JP
Wed Jun 02 00:00:00 UTC 2010
TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ritson GP,Custer SK,Freibaum BD,Guinto JB,Geffel D,Moore J,Tang W,Winton MJ,Neumann M,Trojanowski JQ,Lee VM,Forman MS,Taylor JP
Wed Jun 02 00:00:00 UTC 2010
TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ritson GP,Custer SK,Freibaum BD,Guinto JB,Geffel D,Moore J,Tang W,Winton MJ,Neumann M,Trojanowski JQ,Lee VM,Forman MS,Taylor JP
Wed Jun 02 00:00:00 UTC 2010
Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Xu YF,Gendron TF,Zhang YJ,Lin WL,D'Alton S,Sheng H,Casey MC,Tong J,Knight J,Yu X,Rademakers R,Boylan K,Hutton M,McGowan E,Dickson DW,Lewis J,Petrucelli L
Wed Aug 11 00:00:00 UTC 2010
Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Xu YF,Gendron TF,Zhang YJ,Lin WL,D'Alton S,Sheng H,Casey MC,Tong J,Knight J,Yu X,Rademakers R,Boylan K,Hutton M,McGowan E,Dickson DW,Lewis J,Petrucelli L
Wed Aug 11 00:00:00 UTC 2010
Caudate atrophy on MRI is a characteristic feature of FTLD-FUS.
European journal of neurology
Josephs KA,Whitwell JL,Parisi JE,Petersen RC,Boeve BF,Jack CR,Dickson DW
Thu Jul 01 00:00:00 UTC 2010
Caudate atrophy on MRI is a characteristic feature of FTLD-FUS.
European journal of neurology
Josephs KA,Whitwell JL,Parisi JE,Petersen RC,Boeve BF,Jack CR,Dickson DW
Thu Jul 01 00:00:00 UTC 2010
Relationship between Bunina bodies and TDP-43 inclusions in spinal anterior horn in amyotrophic lateral sclerosis.
Neuropathology and applied neurobiology
Mori F,Tanji K,Miki Y,Kakita A,Takahashi H,Wakabayashi K
Tue Jun 01 00:00:00 UTC 2010
Relationship between Bunina bodies and TDP-43 inclusions in spinal anterior horn in amyotrophic lateral sclerosis.
Neuropathology and applied neurobiology
Mori F,Tanji K,Miki Y,Kakita A,Takahashi H,Wakabayashi K
Tue Jun 01 00:00:00 UTC 2010
TDP-43 proteinopathy in familial motor neurone disease with TARDBP A315T mutation: a case report.
Neuropathology and applied neurobiology
Cairns NJ,Perrin RJ,Schmidt RE,Gru A,Green KG,Carter D,Taylor-Reinwald L,Morris JC,Gitcho MA,Baloh RH
Wed Dec 01 00:00:00 UTC 2010
TDP-43 proteinopathy in familial motor neurone disease with TARDBP A315T mutation: a case report.
Neuropathology and applied neurobiology
Cairns NJ,Perrin RJ,Schmidt RE,Gru A,Green KG,Carter D,Taylor-Reinwald L,Morris JC,Gitcho MA,Baloh RH
Wed Dec 01 00:00:00 UTC 2010
Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging.
The American journal of pathology
Ahmed Z,Sheng H,Xu YF,Lin WL,Innes AE,Gass J,Yu X,Wuertzer CA,Hou H,Chiba S,Yamanouchi K,Leissring M,Petrucelli L,Nishihara M,Hutton ML,McGowan E,Dickson DW,Lewis J
Thu Jul 01 00:00:00 UTC 2010
Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging.
The American journal of pathology
Ahmed Z,Sheng H,Xu YF,Lin WL,Innes AE,Gass J,Yu X,Wuertzer CA,Hou H,Chiba S,Yamanouchi K,Leissring M,Petrucelli L,Nishihara M,Hutton ML,McGowan E,Dickson DW,Lewis J
Thu Jul 01 00:00:00 UTC 2010
Increased neuronal Rab5 immunoreactive endosomes do not colocalize with TDP-43 in motor neuron disease.
Experimental neurology
Matej R,Botond G,László L,Kopitar-Jerala N,Rusina R,Budka H,Kovacs GG
Wed Sep 01 00:00:00 UTC 2010
Increased neuronal Rab5 immunoreactive endosomes do not colocalize with TDP-43 in motor neuron disease.
Experimental neurology
Matej R,Botond G,László L,Kopitar-Jerala N,Rusina R,Budka H,Kovacs GG
Wed Sep 01 00:00:00 UTC 2010
Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy-Delta(12,14)-prostaglandin J(2).
Experimental neurology
Zhang HX,Tanji K,Yoshida H,Hayakari M,Shibata T,Mori F,Uchida K,Wakabayashi K
Thu Apr 01 00:00:00 UTC 2010
Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy-Delta(12,14)-prostaglandin J(2).
Experimental neurology
Zhang HX,Tanji K,Yoshida H,Hayakari M,Shibata T,Mori F,Uchida K,Wakabayashi K
Thu Apr 01 00:00:00 UTC 2010
Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy-Delta(12,14)-prostaglandin J(2).
Experimental neurology
Zhang HX,Tanji K,Yoshida H,Hayakari M,Shibata T,Mori F,Uchida K,Wakabayashi K
Thu Apr 01 00:00:00 UTC 2010
Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy-Delta(12,14)-prostaglandin J(2).
Experimental neurology
Zhang HX,Tanji K,Yoshida H,Hayakari M,Shibata T,Mori F,Uchida K,Wakabayashi K
Thu Apr 01 00:00:00 UTC 2010
Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy-Delta(12,14)-prostaglandin J(2).
Experimental neurology
Zhang HX,Tanji K,Yoshida H,Hayakari M,Shibata T,Mori F,Uchida K,Wakabayashi K
Thu Apr 01 00:00:00 UTC 2010
Increased caspase activation and decreased TDP-43 solubility in progranulin knockout cortical cultures.
Journal of neurochemistry
Kleinberger G,Wils H,Ponsaerts P,Joris G,Timmermans JP,Van Broeckhoven C,Kumar-Singh S
Mon Nov 01 00:00:00 UTC 2010
Increased caspase activation and decreased TDP-43 solubility in progranulin knockout cortical cultures.
Journal of neurochemistry
Kleinberger G,Wils H,Ponsaerts P,Joris G,Timmermans JP,Van Broeckhoven C,Kumar-Singh S
Mon Nov 01 00:00:00 UTC 2010
Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.
Journal of proteome research
Freibaum BD,Chitta RK,High AA,Taylor JP
Fri Feb 05 00:00:00 UTC 2010
Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.
Journal of proteome research
Freibaum BD,Chitta RK,High AA,Taylor JP
Fri Feb 05 00:00:00 UTC 2010
Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.
Journal of proteome research
Freibaum BD,Chitta RK,High AA,Taylor JP
Fri Feb 05 00:00:00 UTC 2010
Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.
Journal of proteome research
Freibaum BD,Chitta RK,High AA,Taylor JP
Fri Feb 05 00:00:00 UTC 2010
Phosphoproteomic analysis reveals site-specific changes in GFAP and NDRG2 phosphorylation in frontotemporal lobar degeneration.
Journal of proteome research
Herskowitz JH,Seyfried NT,Duong DM,Xia Q,Rees HD,Gearing M,Peng J,Lah JJ,Levey AI
Fri Dec 03 00:00:00 UTC 2010
Phosphoproteomic analysis reveals site-specific changes in GFAP and NDRG2 phosphorylation in frontotemporal lobar degeneration.
Journal of proteome research
Herskowitz JH,Seyfried NT,Duong DM,Xia Q,Rees HD,Gearing M,Peng J,Lah JJ,Levey AI
Fri Dec 03 00:00:00 UTC 2010
Neurotoxic effects of TDP-43 overexpression in C. elegans.
Human molecular genetics
Ash PE,Zhang YJ,Roberts CM,Saldi T,Hutter H,Buratti E,Petrucelli L,Link CD
Sun Aug 15 00:00:00 UTC 2010
Neurotoxic effects of TDP-43 overexpression in C. elegans.
Human molecular genetics
Ash PE,Zhang YJ,Roberts CM,Saldi T,Hutter H,Buratti E,Petrucelli L,Link CD
Sun Aug 15 00:00:00 UTC 2010
Neurotoxic effects of TDP-43 overexpression in C. elegans.
Human molecular genetics
Ash PE,Zhang YJ,Roberts CM,Saldi T,Hutter H,Buratti E,Petrucelli L,Link CD
Sun Aug 15 00:00:00 UTC 2010
Neurotoxic effects of TDP-43 overexpression in C. elegans.
Human molecular genetics
Ash PE,Zhang YJ,Roberts CM,Saldi T,Hutter H,Buratti E,Petrucelli L,Link CD
Sun Aug 15 00:00:00 UTC 2010
Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo.
Human molecular genetics
Kabashi E,Lin L,Tradewell ML,Dion PA,Bercier V,Bourgouin P,Rochefort D,Bel Hadj S,Durham HD,Vande Velde C,Rouleau GA,Drapeau P
Mon Feb 15 00:00:00 UTC 2010
Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo.
Human molecular genetics
Kabashi E,Lin L,Tradewell ML,Dion PA,Bercier V,Bourgouin P,Rochefort D,Bel Hadj S,Durham HD,Vande Velde C,Rouleau GA,Drapeau P
Mon Feb 15 00:00:00 UTC 2010
Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo.
Human molecular genetics
Kabashi E,Lin L,Tradewell ML,Dion PA,Bercier V,Bourgouin P,Rochefort D,Bel Hadj S,Durham HD,Vande Velde C,Rouleau GA,Drapeau P
Mon Feb 15 00:00:00 UTC 2010
Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo.
Human molecular genetics
Kabashi E,Lin L,Tradewell ML,Dion PA,Bercier V,Bourgouin P,Rochefort D,Bel Hadj S,Durham HD,Vande Velde C,Rouleau GA,Drapeau P
Mon Feb 15 00:00:00 UTC 2010
Transgenic mice expressing mutant forms VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and bone.
Human molecular genetics
Custer SK,Neumann M,Lu H,Wright AC,Taylor JP
Sat May 01 00:00:00 UTC 2010
Transgenic mice expressing mutant forms VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and bone.
Human molecular genetics
Custer SK,Neumann M,Lu H,Wright AC,Taylor JP
Sat May 01 00:00:00 UTC 2010
Synergistic effect between proteasome and autophagosome in the clearance of polyubiquitinated TDP-43.
Journal of neuroscience research
Urushitani M,Sato T,Bamba H,Hisa Y,Tooyama I
Mon Mar 01 00:00:00 UTC 2010
Synergistic effect between proteasome and autophagosome in the clearance of polyubiquitinated TDP-43.
Journal of neuroscience research
Urushitani M,Sato T,Bamba H,Hisa Y,Tooyama I
Mon Mar 01 00:00:00 UTC 2010
TDP-43 physically interacts with amyotrophic lateral sclerosis-linked mutant CuZn superoxide dismutase.
Neurochemistry international
Higashi S,Tsuchiya Y,Araki T,Wada K,Kabuta T
Wed Dec 01 00:00:00 UTC 2010
TDP-43 physically interacts with amyotrophic lateral sclerosis-linked mutant CuZn superoxide dismutase.
Neurochemistry international
Higashi S,Tsuchiya Y,Araki T,Wada K,Kabuta T
Wed Dec 01 00:00:00 UTC 2010
TDP-43 physically interacts with amyotrophic lateral sclerosis-linked mutant CuZn superoxide dismutase.
Neurochemistry international
Higashi S,Tsuchiya Y,Araki T,Wada K,Kabuta T
Wed Dec 01 00:00:00 UTC 2010
TDP-43 physically interacts with amyotrophic lateral sclerosis-linked mutant CuZn superoxide dismutase.
Neurochemistry international
Higashi S,Tsuchiya Y,Araki T,Wada K,Kabuta T
Wed Dec 01 00:00:00 UTC 2010
TDP-43 physically interacts with amyotrophic lateral sclerosis-linked mutant CuZn superoxide dismutase.
Neurochemistry international
Higashi S,Tsuchiya Y,Araki T,Wada K,Kabuta T
Wed Dec 01 00:00:00 UTC 2010
TDP-43 dimerizes in human cells in culture.
Cellular and molecular neurobiology
Shiina Y,Arima K,Tabunoki H,Satoh J
Sat May 01 00:00:00 UTC 2010
TDP-43 dimerizes in human cells in culture.
Cellular and molecular neurobiology
Shiina Y,Arima K,Tabunoki H,Satoh J
Sat May 01 00:00:00 UTC 2010
Intra-familial clinical heterogeneity due to FTLD-U with TDP-43 proteinopathy caused by a novel deletion in progranulin gene (PGRN).
Journal of Alzheimer's disease : JAD
Gabryelewicz T,Masellis M,Berdynski M,Bilbao JM,Rogaeva E,St George-Hyslop P,Barczak A,Czyzewski K,Barcikowska M,Wszolek Z,Black SE,Zekanowski C
Wed May 25 00:00:00 UTC 2011
Intra-familial clinical heterogeneity due to FTLD-U with TDP-43 proteinopathy caused by a novel deletion in progranulin gene (PGRN).
Journal of Alzheimer's disease : JAD
Gabryelewicz T,Masellis M,Berdynski M,Bilbao JM,Rogaeva E,St George-Hyslop P,Barczak A,Czyzewski K,Barcikowska M,Wszolek Z,Black SE,Zekanowski C
Wed May 25 00:00:00 UTC 2011
Fus gene mutations in familial and sporadic amyotrophic lateral sclerosis.
Muscle & nerve
Rademakers R,Stewart H,Dejesus-Hernandez M,Krieger C,Graff-Radford N,Fabros M,Briemberg H,Cashman N,Eisen A,Mackenzie IR
Sun Aug 01 00:00:00 UTC 2010
Fus gene mutations in familial and sporadic amyotrophic lateral sclerosis.
Muscle & nerve
Rademakers R,Stewart H,Dejesus-Hernandez M,Krieger C,Graff-Radford N,Fabros M,Briemberg H,Cashman N,Eisen A,Mackenzie IR
Sun Aug 01 00:00:00 UTC 2010
Neuropathological heterogeneity in frontotemporal lobar degeneration with TDP-43 proteinopathy: a quantitative study of 94 cases using principal components analysis.
Journal of neural transmission (Vienna, Austria : 1996)
Armstrong RA,Ellis W,Hamilton RL,Mackenzie IR,Hedreen J,Gearing M,Montine T,Vonsattel JP,Head E,Lieberman AP,Cairns NJ
Mon Feb 01 00:00:00 UTC 2010
Neuropathological heterogeneity in frontotemporal lobar degeneration with TDP-43 proteinopathy: a quantitative study of 94 cases using principal components analysis.
Journal of neural transmission (Vienna, Austria : 1996)
Armstrong RA,Ellis W,Hamilton RL,Mackenzie IR,Hedreen J,Gearing M,Montine T,Vonsattel JP,Head E,Lieberman AP,Cairns NJ
Mon Feb 01 00:00:00 UTC 2010
FALS with FUS mutation in Japan, with early onset, rapid progress and basophilic inclusion.
Journal of human genetics
Suzuki N,Aoki M,Warita H,Kato M,Mizuno H,Shimakura N,Akiyama T,Furuya H,Hokonohara T,Iwaki A,Togashi S,Konno H,Itoyama Y
Thu Apr 01 00:00:00 UTC 2010
FALS with FUS mutation in Japan, with early onset, rapid progress and basophilic inclusion.
Journal of human genetics
Suzuki N,Aoki M,Warita H,Kato M,Mizuno H,Shimakura N,Akiyama T,Furuya H,Hokonohara T,Iwaki A,Togashi S,Konno H,Itoyama Y
Thu Apr 01 00:00:00 UTC 2010
Amyotrophic lateral sclerosis mutant vesicle-associated membrane protein-associated protein-B transgenic mice develop TAR-DNA-binding protein-43 pathology.
Neuroscience
Tudor EL,Galtrey CM,Perkinton MS,Lau KF,De Vos KJ,Mitchell JC,Ackerley S,Hortobágyi T,Vámos E,Leigh PN,Klasen C,McLoughlin DM,Shaw CE,Miller CC
Wed May 19 00:00:00 UTC 2010
Amyotrophic lateral sclerosis mutant vesicle-associated membrane protein-associated protein-B transgenic mice develop TAR-DNA-binding protein-43 pathology.
Neuroscience
Tudor EL,Galtrey CM,Perkinton MS,Lau KF,De Vos KJ,Mitchell JC,Ackerley S,Hortobágyi T,Vámos E,Leigh PN,Klasen C,McLoughlin DM,Shaw CE,Miller CC
Wed May 19 00:00:00 UTC 2010
Progranulin deficiency leads to enhanced cell vulnerability and TDP-43 translocation in primary neuronal cultures.
Brain research
Guo A,Tapia L,Bamji SX,Cynader MS,Jia W
Fri Dec 17 00:00:00 UTC 2010
Progranulin deficiency leads to enhanced cell vulnerability and TDP-43 translocation in primary neuronal cultures.
Brain research
Guo A,Tapia L,Bamji SX,Cynader MS,Jia W
Fri Dec 17 00:00:00 UTC 2010
TDP43-positive intraneuronal inclusions in a patient with motor neuron disease and Parkinson's disease.
Neuro-degenerative diseases
Chanson JB,Echaniz-Laguna A,Vogel T,Mohr M,Benoilid A,Kaltenbach G,Kiesmann M
Mon Jan 31 00:00:00 UTC 2011
TDP43-positive intraneuronal inclusions in a patient with motor neuron disease and Parkinson's disease.
Neuro-degenerative diseases
Chanson JB,Echaniz-Laguna A,Vogel T,Mohr M,Benoilid A,Kaltenbach G,Kiesmann M
Mon Jan 31 00:00:00 UTC 2011
Mutant superoxide dismutase 1 overexpression in NSC-34 cells: effect of trehalose on aggregation, TDP-43 localization and levels of co-expressed glycoproteins.
Neuroscience letters
Gomes C,Escrevente C,Costa J
Fri May 21 00:00:00 UTC 2010
Mutant superoxide dismutase 1 overexpression in NSC-34 cells: effect of trehalose on aggregation, TDP-43 localization and levels of co-expressed glycoproteins.
Neuroscience letters
Gomes C,Escrevente C,Costa J
Fri May 21 00:00:00 UTC 2010
Alterations in subcellular localization of TDP-43 immunoreactivity in the anterior horns in sporadic amyotrophic lateral sclerosis.
Neuroscience letters
Sasaki S,Takeda T,Shibata N,Kobayashi M
Mon Jul 05 00:00:00 UTC 2010
Alterations in subcellular localization of TDP-43 immunoreactivity in the anterior horns in sporadic amyotrophic lateral sclerosis.
Neuroscience letters
Sasaki S,Takeda T,Shibata N,Kobayashi M
Mon Jul 05 00:00:00 UTC 2010
Pathologic evidence that the T188R mutation in PRNP is associated with prion disease.
Journal of neuropathology and experimental neurology
Tartaglia MC,Thai JN,See T,Kuo A,Harbaugh R,Raudabaugh B,Cali I,Sattavat M,Sanchez H,DeArmond SJ,Geschwind MD
Wed Dec 01 00:00:00 UTC 2010
Pathologic evidence that the T188R mutation in PRNP is associated with prion disease.
Journal of neuropathology and experimental neurology
Tartaglia MC,Thai JN,See T,Kuo A,Harbaugh R,Raudabaugh B,Cali I,Sattavat M,Sanchez H,DeArmond SJ,Geschwind MD
Wed Dec 01 00:00:00 UTC 2010
Abnormal TDP-43 expression is identified in the neocortex in cases of dementia pugilistica, but is mainly confined to the limbic system when identified in high and moderate stages of Alzheimer's disease.
Neuropathology : official journal of the Japanese Society of Neuropathology
King A,Sweeney F,Bodi I,Troakes C,Maekawa S,Al-Sarraj S
Sun Aug 01 00:00:00 UTC 2010
Abnormal TDP-43 expression is identified in the neocortex in cases of dementia pugilistica, but is mainly confined to the limbic system when identified in high and moderate stages of Alzheimer's disease.
Neuropathology : official journal of the Japanese Society of Neuropathology
King A,Sweeney F,Bodi I,Troakes C,Maekawa S,Al-Sarraj S
Sun Aug 01 00:00:00 UTC 2010
Sporadic amyotrophic lateral sclerosis with pallido-nigro-luysian degeneration: a TDP-43 immunohistochemical study.
Neuropathology : official journal of the Japanese Society of Neuropathology
Miki Y,Mori F,Nunomura J,Ookawa K,Yajima N,Yagihashi S,Wakabayashi K
Thu Apr 01 00:00:00 UTC 2010
Sporadic amyotrophic lateral sclerosis with pallido-nigro-luysian degeneration: a TDP-43 immunohistochemical study.
Neuropathology : official journal of the Japanese Society of Neuropathology
Miki Y,Mori F,Nunomura J,Ookawa K,Yajima N,Yagihashi S,Wakabayashi K
Thu Apr 01 00:00:00 UTC 2010
Pseudopolyneuritic form of ALS revisited: clinical and pathological heterogeneity.
Neuropathology : official journal of the Japanese Society of Neuropathology
Kobayashi Z,Tsuchiya K,Arai T,Yokota O,Watabiki S,Ishizu H,Akiyama H,Mizusawa H
Sun Aug 01 00:00:00 UTC 2010
Pseudopolyneuritic form of ALS revisited: clinical and pathological heterogeneity.
Neuropathology : official journal of the Japanese Society of Neuropathology
Kobayashi Z,Tsuchiya K,Arai T,Yokota O,Watabiki S,Ishizu H,Akiyama H,Mizusawa H
Sun Aug 01 00:00:00 UTC 2010
Widespread occurrence of eosinophilic neuronal cytoplasmic inclusions in an asymptomatic adult: a novel ubiquitin-negative filamentous inclusion.
Neuropathology : official journal of the Japanese Society of Neuropathology
Mori F,Miki Y,Tanji K,Kusumi T,Kijima H,Wakabayashi K
Wed Dec 01 00:00:00 UTC 2010
Widespread occurrence of eosinophilic neuronal cytoplasmic inclusions in an asymptomatic adult: a novel ubiquitin-negative filamentous inclusion.
Neuropathology : official journal of the Japanese Society of Neuropathology
Mori F,Miki Y,Tanji K,Kusumi T,Kijima H,Wakabayashi K
Wed Dec 01 00:00:00 UTC 2010
TDP-43 M337V mutation in familial amyotrophic lateral sclerosis in Japan.
Internal medicine (Tokyo, Japan)
Tamaoka A,Arai M,Itokawa M,Arai T,Hasegawa M,Tsuchiya K,Takuma H,Tsuji H,Ishii A,Watanabe M,Takahashi Y,Goto J,Tsuji S,Akiyama H
Tue May 25 00:00:00 UTC 2010
TDP-43 M337V mutation in familial amyotrophic lateral sclerosis in Japan.
Internal medicine (Tokyo, Japan)
Tamaoka A,Arai M,Itokawa M,Arai T,Hasegawa M,Tsuchiya K,Takuma H,Tsuji H,Ishii A,Watanabe M,Takahashi Y,Goto J,Tsuji S,Akiyama H
Tue May 25 00:00:00 UTC 2010
Transgenic rat model of neurodegeneration caused by mutation in the TDP gene.
PLoS genetics
Zhou H,Huang C,Chen H,Wang D,Landel CP,Xia PY,Bowser R,Liu YJ,Xia XG
Fri Mar 26 00:00:00 UTC 2010
Transgenic rat model of neurodegeneration caused by mutation in the TDP gene.
PLoS genetics
Zhou H,Huang C,Chen H,Wang D,Landel CP,Xia PY,Bowser R,Liu YJ,Xia XG
Fri Mar 26 00:00:00 UTC 2010
Transgenic rat model of neurodegeneration caused by mutation in the TDP gene.
PLoS genetics
Zhou H,Huang C,Chen H,Wang D,Landel CP,Xia PY,Bowser R,Liu YJ,Xia XG
Fri Mar 26 00:00:00 UTC 2010
Transgenic rat model of neurodegeneration caused by mutation in the TDP gene.
PLoS genetics
Zhou H,Huang C,Chen H,Wang D,Landel CP,Xia PY,Bowser R,Liu YJ,Xia XG
Fri Mar 26 00:00:00 UTC 2010
Transgenic rat model of neurodegeneration caused by mutation in the TDP gene.
PLoS genetics
Zhou H,Huang C,Chen H,Wang D,Landel CP,Xia PY,Bowser R,Liu YJ,Xia XG
Fri Mar 26 00:00:00 UTC 2010
Multiplex SILAC analysis of a cellular TDP-43 proteinopathy model reveals protein inclusions associated with SUMOylation and diverse polyubiquitin chains.
Molecular & cellular proteomics : MCP
Seyfried NT,Gozal YM,Dammer EB,Xia Q,Duong DM,Cheng D,Lah JJ,Levey AI,Peng J
Thu Apr 01 00:00:00 UTC 2010
Multiplex SILAC analysis of a cellular TDP-43 proteinopathy model reveals protein inclusions associated with SUMOylation and diverse polyubiquitin chains.
Molecular & cellular proteomics : MCP
Seyfried NT,Gozal YM,Dammer EB,Xia Q,Duong DM,Cheng D,Lah JJ,Levey AI,Peng J
Thu Apr 01 00:00:00 UTC 2010
Multiplex SILAC analysis of a cellular TDP-43 proteinopathy model reveals protein inclusions associated with SUMOylation and diverse polyubiquitin chains.
Molecular & cellular proteomics : MCP
Seyfried NT,Gozal YM,Dammer EB,Xia Q,Duong DM,Cheng D,Lah JJ,Levey AI,Peng J
Thu Apr 01 00:00:00 UTC 2010
Multiplex SILAC analysis of a cellular TDP-43 proteinopathy model reveals protein inclusions associated with SUMOylation and diverse polyubiquitin chains.
Molecular & cellular proteomics : MCP
Seyfried NT,Gozal YM,Dammer EB,Xia Q,Duong DM,Cheng D,Lah JJ,Levey AI,Peng J
Thu Apr 01 00:00:00 UTC 2010
Alzheimer disease-like phenotype associated with the c.154delA mutation in progranulin.
Archives of neurology
Kelley BJ,Haidar W,Boeve BF,Baker M,Shiung M,Knopman DS,Rademakers R,Hutton M,Adamson J,Kuntz KM,Dickson DW,Parisi JE,Smith GE,Petersen RC
Mon Feb 01 00:00:00 UTC 2010
Alzheimer disease-like phenotype associated with the c.154delA mutation in progranulin.
Archives of neurology
Kelley BJ,Haidar W,Boeve BF,Baker M,Shiung M,Knopman DS,Rademakers R,Hutton M,Adamson J,Kuntz KM,Dickson DW,Parisi JE,Smith GE,Petersen RC
Mon Feb 01 00:00:00 UTC 2010
Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis.
Acta neuropathologica
Kraemer BC,Schuck T,Wheeler JM,Robinson LC,Trojanowski JQ,Lee VM,Schellenberg GD
Thu Apr 01 00:00:00 UTC 2010
Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis.
Acta neuropathologica
Kraemer BC,Schuck T,Wheeler JM,Robinson LC,Trojanowski JQ,Lee VM,Schellenberg GD
Thu Apr 01 00:00:00 UTC 2010
Age-dependent changes in TDP-43 levels in a mouse model of Alzheimer disease are linked to Aβ oligomers accumulation.
Molecular neurodegeneration
Caccamo A,Magrí A,Oddo S
Thu Nov 11 00:00:00 UTC 2010
Age-dependent changes in TDP-43 levels in a mouse model of Alzheimer disease are linked to Aβ oligomers accumulation.
Molecular neurodegeneration
Caccamo A,Magrí A,Oddo S
Thu Nov 11 00:00:00 UTC 2010
Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43.
The Journal of biological chemistry
Nishimoto Y,Ito D,Yagi T,Nihei Y,Tsunoda Y,Suzuki N
Fri Jan 01 00:00:00 UTC 2010
Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43.
The Journal of biological chemistry
Nishimoto Y,Ito D,Yagi T,Nihei Y,Tsunoda Y,Suzuki N
Fri Jan 01 00:00:00 UTC 2010
Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43.
The Journal of biological chemistry
Nishimoto Y,Ito D,Yagi T,Nihei Y,Tsunoda Y,Suzuki N
Fri Jan 01 00:00:00 UTC 2010
Sustained expression of TDP-43 and FUS in motor neurons in rodent's lifetime.
International journal of biological sciences
Huang C,Xia PY,Zhou H
Sun Jul 04 00:00:00 UTC 2010
Sustained expression of TDP-43 and FUS in motor neurons in rodent's lifetime.
International journal of biological sciences
Huang C,Xia PY,Zhou H
Sun Jul 04 00:00:00 UTC 2010
International Workshop on Inclusion Body Myositis held at the Institute of Myology, Paris, on 29 May 2009.
Neuromuscular disorders : NMD
Benveniste O,Hilton-Jones D
Tue Jun 01 00:00:00 UTC 2010
Pathological 43-kDa transactivation response DNA-binding protein in older adults with and without severe mental illness.
Archives of neurology
Geser F,Robinson JL,Malunda JA,Xie SX,Clark CM,Kwong LK,Moberg PJ,Moore EM,Van Deerlin VM,Lee VM,Arnold SE,Trojanowski JQ
Fri Oct 01 00:00:00 UTC 2010
Pathological 43-kDa transactivation response DNA-binding protein in older adults with and without severe mental illness.
Archives of neurology
Geser F,Robinson JL,Malunda JA,Xie SX,Clark CM,Kwong LK,Moberg PJ,Moore EM,Van Deerlin VM,Lee VM,Arnold SE,Trojanowski JQ
Fri Oct 01 00:00:00 UTC 2010
TDP-43 and ubiquitinated cytoplasmic aggregates in sporadic ALS are low frequency and widely distributed in the lower motor neuron columns independent of disease spread.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
Bodansky A,Kim JM,Tempest L,Velagapudi A,Libby R,Ravits J
Mon May 03 00:00:00 UTC 2010
TDP-43 and ubiquitinated cytoplasmic aggregates in sporadic ALS are low frequency and widely distributed in the lower motor neuron columns independent of disease spread.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
Bodansky A,Kim JM,Tempest L,Velagapudi A,Libby R,Ravits J
Mon May 03 00:00:00 UTC 2010
Ubiquilin modifies TDP-43 toxicity in a Drosophila model of amyotrophic lateral sclerosis (ALS).
The Journal of biological chemistry
Hanson KA,Kim SH,Wassarman DA,Tibbetts RS
Fri Apr 09 00:00:00 UTC 2010
Ubiquilin modifies TDP-43 toxicity in a Drosophila model of amyotrophic lateral sclerosis (ALS).
The Journal of biological chemistry
Hanson KA,Kim SH,Wassarman DA,Tibbetts RS
Fri Apr 09 00:00:00 UTC 2010
Ubiquilin modifies TDP-43 toxicity in a Drosophila model of amyotrophic lateral sclerosis (ALS).
The Journal of biological chemistry
Hanson KA,Kim SH,Wassarman DA,Tibbetts RS
Fri Apr 09 00:00:00 UTC 2010
Ubiquilin modifies TDP-43 toxicity in a Drosophila model of amyotrophic lateral sclerosis (ALS).
The Journal of biological chemistry
Hanson KA,Kim SH,Wassarman DA,Tibbetts RS
Fri Apr 09 00:00:00 UTC 2010
TDP-43-mediated neuron loss in vivo requires RNA-binding activity.
PloS one
Voigt A,Herholz D,Fiesel FC,Kaur K,Müller D,Karsten P,Weber SS,Kahle PJ,Marquardt T,Schulz JB
Wed Aug 18 00:00:00 UTC 2010
TDP-43-mediated neuron loss in vivo requires RNA-binding activity.
PloS one
Voigt A,Herholz D,Fiesel FC,Kaur K,Müller D,Karsten P,Weber SS,Kahle PJ,Marquardt T,Schulz JB
Wed Aug 18 00:00:00 UTC 2010
Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43.
The Journal of biological chemistry
Fuentealba RA,Udan M,Bell S,Wegorzewska I,Shao J,Diamond MI,Weihl CC,Baloh RH
Fri Aug 20 00:00:00 UTC 2010
Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43.
The Journal of biological chemistry
Fuentealba RA,Udan M,Bell S,Wegorzewska I,Shao J,Diamond MI,Weihl CC,Baloh RH
Fri Aug 20 00:00:00 UTC 2010
Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43.
The Journal of biological chemistry
Fuentealba RA,Udan M,Bell S,Wegorzewska I,Shao J,Diamond MI,Weihl CC,Baloh RH
Fri Aug 20 00:00:00 UTC 2010
Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43.
The Journal of biological chemistry
Fuentealba RA,Udan M,Bell S,Wegorzewska I,Shao J,Diamond MI,Weihl CC,Baloh RH
Fri Aug 20 00:00:00 UTC 2010
Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA.
The Journal of biological chemistry
Kim SH,Shanware NP,Bowler MJ,Tibbetts RS
Fri Oct 29 00:00:00 UTC 2010
Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA.
The Journal of biological chemistry
Kim SH,Shanware NP,Bowler MJ,Tibbetts RS
Fri Oct 29 00:00:00 UTC 2010
Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA.
The Journal of biological chemistry
Kim SH,Shanware NP,Bowler MJ,Tibbetts RS
Fri Oct 29 00:00:00 UTC 2010
Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA.
The Journal of biological chemistry
Kim SH,Shanware NP,Bowler MJ,Tibbetts RS
Fri Oct 29 00:00:00 UTC 2010
The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism.
PloS one
Yang C,Tan W,Whittle C,Qiu L,Cao L,Akbarian S,Xu Z
Fri Dec 31 00:00:00 UTC 2010
The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism.
PloS one
Yang C,Tan W,Whittle C,Qiu L,Cao L,Akbarian S,Xu Z
Fri Dec 31 00:00:00 UTC 2010
The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism.
PloS one
Yang C,Tan W,Whittle C,Qiu L,Cao L,Akbarian S,Xu Z
Fri Dec 31 00:00:00 UTC 2010
The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism.
PloS one
Yang C,Tan W,Whittle C,Qiu L,Cao L,Akbarian S,Xu Z
Fri Dec 31 00:00:00 UTC 2010
Progranulin is neurotrophic in vivo and protects against a mutant TDP-43 induced axonopathy.
PloS one
Laird AS,Van Hoecke A,De Muynck L,Timmers M,Van den Bosch L,Van Damme P,Robberecht W
Wed Oct 13 00:00:00 UTC 2010
Progranulin is neurotrophic in vivo and protects against a mutant TDP-43 induced axonopathy.
PloS one
Laird AS,Van Hoecke A,De Muynck L,Timmers M,Van den Bosch L,Van Damme P,Robberecht W
Wed Oct 13 00:00:00 UTC 2010
Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking.
PloS one
Hadano S,Otomo A,Kunita R,Suzuki-Utsunomiya K,Akatsuka A,Koike M,Aoki M,Uchiyama Y,Itoyama Y,Ikeda JE
Mon Mar 22 00:00:00 UTC 2010
Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking.
PloS one
Hadano S,Otomo A,Kunita R,Suzuki-Utsunomiya K,Akatsuka A,Koike M,Aoki M,Uchiyama Y,Itoyama Y,Ikeda JE
Mon Mar 22 00:00:00 UTC 2010
Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue.
PloS one
Liu-Yesucevitz L,Bilgutay A,Zhang YJ,Vanderweyde T,Citro A,Mehta T,Zaarur N,McKee A,Bowser R,Sherman M,Petrucelli L,Wolozin B
Mon Oct 11 00:00:00 UTC 2010
Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue.
PloS one
Liu-Yesucevitz L,Bilgutay A,Zhang YJ,Vanderweyde T,Citro A,Mehta T,Zaarur N,McKee A,Bowser R,Sherman M,Petrucelli L,Wolozin B
Mon Oct 11 00:00:00 UTC 2010
TDP-43 is a developmentally regulated protein essential for early embryonic development.
The Journal of biological chemistry
Sephton CF,Good SK,Atkin S,Dewey CM,Mayer P,Herz J,Yu G
Fri Feb 26 00:00:00 UTC 2010
TDP-43 is a developmentally regulated protein essential for early embryonic development.
The Journal of biological chemistry
Sephton CF,Good SK,Atkin S,Dewey CM,Mayer P,Herz J,Yu G
Fri Feb 26 00:00:00 UTC 2010
TDP-43 is a developmentally regulated protein essential for early embryonic development.
The Journal of biological chemistry
Sephton CF,Good SK,Atkin S,Dewey CM,Mayer P,Herz J,Yu G
Fri Feb 26 00:00:00 UTC 2010
TDP-43 is a developmentally regulated protein essential for early embryonic development.
The Journal of biological chemistry
Sephton CF,Good SK,Atkin S,Dewey CM,Mayer P,Herz J,Yu G
Fri Feb 26 00:00:00 UTC 2010
Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6.
Science (New York, N.Y.)
Vance C,Rogelj B,Hortobágyi T,De Vos KJ,Nishimura AL,Sreedharan J,Hu X,Smith B,Ruddy D,Wright P,Ganesalingam J,Williams KL,Tripathi V,Al-Saraj S,Al-Chalabi A,Leigh PN,Blair IP,Nicholson G,de Belleroche J,Gallo JM,Miller CC,Shaw CE
Fri Feb 27 00:00:00 UTC 2009
Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6.
Science (New York, N.Y.)
Vance C,Rogelj B,Hortobágyi T,De Vos KJ,Nishimura AL,Sreedharan J,Hu X,Smith B,Ruddy D,Wright P,Ganesalingam J,Williams KL,Tripathi V,Al-Saraj S,Al-Chalabi A,Leigh PN,Blair IP,Nicholson G,de Belleroche J,Gallo JM,Miller CC,Shaw CE
Fri Feb 27 00:00:00 UTC 2009
TDP-43 in ubiquitinated inclusions in the inferior olives in frontotemporal lobar degeneration and in other neurodegenerative diseases: a degenerative process distinct from normal ageing.
Acta neuropathologica
Davidson Y,Amin H,Kelley T,Shi J,Tian J,Kumaran R,Lashley T,Lees AJ,DuPlessis D,Neary D,Snowden J,Akiyama H,Arai T,Hasegawa M,Bandopadhyay R,Sikkink S,Pickering-Brown S,Mann DM
Tue Sep 01 00:00:00 UTC 2009
TDP-43 in ubiquitinated inclusions in the inferior olives in frontotemporal lobar degeneration and in other neurodegenerative diseases: a degenerative process distinct from normal ageing.
Acta neuropathologica
Davidson Y,Amin H,Kelley T,Shi J,Tian J,Kumaran R,Lashley T,Lees AJ,DuPlessis D,Neary D,Snowden J,Akiyama H,Arai T,Hasegawa M,Bandopadhyay R,Sikkink S,Pickering-Brown S,Mann DM
Tue Sep 01 00:00:00 UTC 2009
Hippocampal sclerosis with four-repeat tau-positive round inclusions in the dentate gyrus: a new type of four-repeat tauopathy.
Acta neuropathologica
Miki Y,Mori F,Hori E,Kaimori M,Wakabayashi K
Mon Jun 01 00:00:00 UTC 2009
Hippocampal sclerosis with four-repeat tau-positive round inclusions in the dentate gyrus: a new type of four-repeat tauopathy.
Acta neuropathologica
Miki Y,Mori F,Hori E,Kaimori M,Wakabayashi K
Mon Jun 01 00:00:00 UTC 2009
Accumulation of phosphorylated TDP-43 in brains of patients with argyrophilic grain disease.
Acta neuropathologica
Fujishiro H,Uchikado H,Arai T,Hasegawa M,Akiyama H,Yokota O,Tsuchiya K,Togo T,Iseki E,Hirayasu Y
Sun Feb 01 00:00:00 UTC 2009
Accumulation of phosphorylated TDP-43 in brains of patients with argyrophilic grain disease.
Acta neuropathologica
Fujishiro H,Uchikado H,Arai T,Hasegawa M,Akiyama H,Yokota O,Tsuchiya K,Togo T,Iseki E,Hirayasu Y
Sun Feb 01 00:00:00 UTC 2009
Accumulation of phosphorylated TDP-43 in brains of patients with argyrophilic grain disease.
Acta neuropathologica
Fujishiro H,Uchikado H,Arai T,Hasegawa M,Akiyama H,Yokota O,Tsuchiya K,Togo T,Iseki E,Hirayasu Y
Sun Feb 01 00:00:00 UTC 2009
Progression of hippocampal degeneration in amyotrophic lateral sclerosis with or without memory impairment: distinction from Alzheimer disease.
Acta neuropathologica
Takeda T,Uchihara T,Arai N,Mizutani T,Iwata M
Thu Jan 01 00:00:00 UTC 2009
Progression of hippocampal degeneration in amyotrophic lateral sclerosis with or without memory impairment: distinction from Alzheimer disease.
Acta neuropathologica
Takeda T,Uchihara T,Arai N,Mizutani T,Iwata M
Thu Jan 01 00:00:00 UTC 2009
Progression of hippocampal degeneration in amyotrophic lateral sclerosis with or without memory impairment: distinction from Alzheimer disease.
Acta neuropathologica
Takeda T,Uchihara T,Arai N,Mizutani T,Iwata M
Thu Jan 01 00:00:00 UTC 2009
Evaluation of subcortical pathology and clinical correlations in FTLD-U subtypes.
Acta neuropathologica
Josephs KA,Stroh A,Dugger B,Dickson DW
Tue Sep 01 00:00:00 UTC 2009
Evaluation of subcortical pathology and clinical correlations in FTLD-U subtypes.
Acta neuropathologica
Josephs KA,Stroh A,Dugger B,Dickson DW
Tue Sep 01 00:00:00 UTC 2009
Accumulation of TDP-43 and alpha-actin in an amyotrophic lateral sclerosis patient with the K17I ANG mutation.
Acta neuropathologica
Seilhean D,Cazeneuve C,Thuriès V,Russaouen O,Millecamps S,Salachas F,Meininger V,Leguern E,Duyckaerts C
Thu Oct 01 00:00:00 UTC 2009
Accumulation of TDP-43 and alpha-actin in an amyotrophic lateral sclerosis patient with the K17I ANG mutation.
Acta neuropathologica
Seilhean D,Cazeneuve C,Thuriès V,Russaouen O,Millecamps S,Salachas F,Meininger V,Leguern E,Duyckaerts C
Thu Oct 01 00:00:00 UTC 2009
TDP-43 accumulation is common in myopathies with rimmed vacuoles.
Acta neuropathologica
Küsters B,van Hoeve BJ,Schelhaas HJ,Ter Laak H,van Engelen BG,Lammens M
Sun Feb 01 00:00:00 UTC 2009
TDP-43 accumulation is common in myopathies with rimmed vacuoles.
Acta neuropathologica
Küsters B,van Hoeve BJ,Schelhaas HJ,Ter Laak H,van Engelen BG,Lammens M
Sun Feb 01 00:00:00 UTC 2009
Selective occurrence of TDP-43-immunoreactive inclusions in the lower motor neurons in Machado-Joseph disease.
Acta neuropathologica
Tan CF,Yamada M,Toyoshima Y,Yokoseki A,Miki Y,Hoshi Y,Kaneko H,Ikeuchi T,Onodera O,Kakita A,Takahashi H
Thu Oct 01 00:00:00 UTC 2009
Selective occurrence of TDP-43-immunoreactive inclusions in the lower motor neurons in Machado-Joseph disease.
Acta neuropathologica
Tan CF,Yamada M,Toyoshima Y,Yokoseki A,Miki Y,Hoshi Y,Kaneko H,Ikeuchi T,Onodera O,Kakita A,Takahashi H
Thu Oct 01 00:00:00 UTC 2009
Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease.
Acta neuropathologica
Neumann M,Roeber S,Kretzschmar HA,Rademakers R,Baker M,Mackenzie IR
Sun Nov 01 00:00:00 UTC 2009
Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease.
Acta neuropathologica
Neumann M,Roeber S,Kretzschmar HA,Rademakers R,Baker M,Mackenzie IR
Sun Nov 01 00:00:00 UTC 2009
Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies.
Acta neuropathologica
Neumann M,Kwong LK,Lee EB,Kremmer E,Flatley A,Xu Y,Forman MS,Troost D,Kretzschmar HA,Trojanowski JQ,Lee VM
Sun Feb 01 00:00:00 UTC 2009
Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies.
Acta neuropathologica
Neumann M,Kwong LK,Lee EB,Kremmer E,Flatley A,Xu Y,Forman MS,Troost D,Kretzschmar HA,Trojanowski JQ,Lee VM
Sun Feb 01 00:00:00 UTC 2009
Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies.
Acta neuropathologica
Neumann M,Kwong LK,Lee EB,Kremmer E,Flatley A,Xu Y,Forman MS,Troost D,Kretzschmar HA,Trojanowski JQ,Lee VM
Sun Feb 01 00:00:00 UTC 2009
Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies.
Acta neuropathologica
Neumann M,Kwong LK,Lee EB,Kremmer E,Flatley A,Xu Y,Forman MS,Troost D,Kretzschmar HA,Trojanowski JQ,Lee VM
Sun Feb 01 00:00:00 UTC 2009
Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies.
Acta neuropathologica
Neumann M,Kwong LK,Lee EB,Kremmer E,Flatley A,Xu Y,Forman MS,Troost D,Kretzschmar HA,Trojanowski JQ,Lee VM
Sun Feb 01 00:00:00 UTC 2009
Plasma phosphorylated-TDP-43 protein levels correlate with brain pathology in frontotemporal lobar degeneration.
Acta neuropathologica
Foulds PG,Davidson Y,Mishra M,Hobson DJ,Humphreys KM,Taylor M,Johnson N,Weintraub S,Akiyama H,Arai T,Hasegawa M,Bigio EH,Benson FE,Allsop D,Mann DM
Sun Nov 01 00:00:00 UTC 2009
Plasma phosphorylated-TDP-43 protein levels correlate with brain pathology in frontotemporal lobar degeneration.
Acta neuropathologica
Foulds PG,Davidson Y,Mishra M,Hobson DJ,Humphreys KM,Taylor M,Johnson N,Weintraub S,Akiyama H,Arai T,Hasegawa M,Bigio EH,Benson FE,Allsop D,Mann DM
Sun Nov 01 00:00:00 UTC 2009
Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies.
Acta neuropathologica
Arai T,Mackenzie IR,Hasegawa M,Nonoka T,Niizato K,Tsuchiya K,Iritani S,Onaya M,Akiyama H
Sun Feb 01 00:00:00 UTC 2009
Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies.
Acta neuropathologica
Arai T,Mackenzie IR,Hasegawa M,Nonoka T,Niizato K,Tsuchiya K,Iritani S,Onaya M,Akiyama H
Sun Feb 01 00:00:00 UTC 2009
Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies.
Acta neuropathologica
Arai T,Mackenzie IR,Hasegawa M,Nonoka T,Niizato K,Tsuchiya K,Iritani S,Onaya M,Akiyama H
Sun Feb 01 00:00:00 UTC 2009
Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies.
Acta neuropathologica
Arai T,Mackenzie IR,Hasegawa M,Nonoka T,Niizato K,Tsuchiya K,Iritani S,Onaya M,Akiyama H
Sun Feb 01 00:00:00 UTC 2009
Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies.
Acta neuropathologica
Arai T,Mackenzie IR,Hasegawa M,Nonoka T,Niizato K,Tsuchiya K,Iritani S,Onaya M,Akiyama H
Sun Feb 01 00:00:00 UTC 2009
TARDBP 3'-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy.
Acta neuropathologica
Gitcho MA,Bigio EH,Mishra M,Johnson N,Weintraub S,Mesulam M,Rademakers R,Chakraverty S,Cruchaga C,Morris JC,Goate AM,Cairns NJ
Sun Nov 01 00:00:00 UTC 2009
TARDBP 3'-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy.
Acta neuropathologica
Gitcho MA,Bigio EH,Mishra M,Johnson N,Weintraub S,Mesulam M,Rademakers R,Chakraverty S,Cruchaga C,Morris JC,Goate AM,Cairns NJ
Sun Nov 01 00:00:00 UTC 2009
Sporadic amyotrophic lateral sclerosis of long duration is associated with relatively mild TDP-43 pathology.
Acta neuropathologica
Nishihira Y,Tan CF,Hoshi Y,Iwanaga K,Yamada M,Kawachi I,Tsujihata M,Hozumi I,Morita T,Onodera O,Nishizawa M,Kakita A,Takahashi H
Thu Jan 01 00:00:00 UTC 2009
Sporadic amyotrophic lateral sclerosis of long duration is associated with relatively mild TDP-43 pathology.
Acta neuropathologica
Nishihira Y,Tan CF,Hoshi Y,Iwanaga K,Yamada M,Kawachi I,Tsujihata M,Hozumi I,Morita T,Onodera O,Nishizawa M,Kakita A,Takahashi H
Thu Jan 01 00:00:00 UTC 2009
TDP-43 pathology in familial British dementia.
Acta neuropathologica
Schwab C,Arai T,Hasegawa M,Akiyama H,Yu S,McGeer PL
Sat Aug 01 00:00:00 UTC 2009
TDP-43 pathology in familial British dementia.
Acta neuropathologica
Schwab C,Arai T,Hasegawa M,Akiyama H,Yu S,McGeer PL
Sat Aug 01 00:00:00 UTC 2009
TDP-43 pathology in familial British dementia.
Acta neuropathologica
Schwab C,Arai T,Hasegawa M,Akiyama H,Yu S,McGeer PL
Sat Aug 01 00:00:00 UTC 2009
Increased TDP-43 protein in cerebrospinal fluid of patients with amyotrophic lateral sclerosis.
Acta neuropathologica
Kasai T,Tokuda T,Ishigami N,Sasayama H,Foulds P,Mitchell DJ,Mann DM,Allsop D,Nakagawa M
Thu Jan 01 00:00:00 UTC 2009
Increased TDP-43 protein in cerebrospinal fluid of patients with amyotrophic lateral sclerosis.
Acta neuropathologica
Kasai T,Tokuda T,Ishigami N,Sasayama H,Foulds P,Mitchell DJ,Mann DM,Allsop D,Nakagawa M
Thu Jan 01 00:00:00 UTC 2009
Increased TDP-43 protein in cerebrospinal fluid of patients with amyotrophic lateral sclerosis.
Acta neuropathologica
Kasai T,Tokuda T,Ishigami N,Sasayama H,Foulds P,Mitchell DJ,Mann DM,Allsop D,Nakagawa M
Thu Jan 01 00:00:00 UTC 2009
Increased TDP-43 protein in cerebrospinal fluid of patients with amyotrophic lateral sclerosis.
Acta neuropathologica
Kasai T,Tokuda T,Ishigami N,Sasayama H,Foulds P,Mitchell DJ,Mann DM,Allsop D,Nakagawa M
Thu Jan 01 00:00:00 UTC 2009
A new subtype of frontotemporal lobar degeneration with FUS pathology.
Brain : a journal of neurology
Neumann M,Rademakers R,Roeber S,Baker M,Kretzschmar HA,Mackenzie IR
Sun Nov 01 00:00:00 UTC 2009
A new subtype of frontotemporal lobar degeneration with FUS pathology.
Brain : a journal of neurology
Neumann M,Rademakers R,Roeber S,Baker M,Kretzschmar HA,Mackenzie IR
Sun Nov 01 00:00:00 UTC 2009
Mimicking aspects of frontotemporal lobar degeneration and Lou Gehrig's disease in rats via TDP-43 overexpression.
Molecular therapy : the journal of the American Society of Gene Therapy
Tatom JB,Wang DB,Dayton RD,Skalli O,Hutton ML,Dickson DW,Klein RL
Wed Apr 01 00:00:00 UTC 2009
Mimicking aspects of frontotemporal lobar degeneration and Lou Gehrig's disease in rats via TDP-43 overexpression.
Molecular therapy : the journal of the American Society of Gene Therapy
Tatom JB,Wang DB,Dayton RD,Skalli O,Hutton ML,Dickson DW,Klein RL
Wed Apr 01 00:00:00 UTC 2009
Mimicking aspects of frontotemporal lobar degeneration and Lou Gehrig's disease in rats via TDP-43 overexpression.
Molecular therapy : the journal of the American Society of Gene Therapy
Tatom JB,Wang DB,Dayton RD,Skalli O,Hutton ML,Dickson DW,Klein RL
Wed Apr 01 00:00:00 UTC 2009
Mimicking aspects of frontotemporal lobar degeneration and Lou Gehrig's disease in rats via TDP-43 overexpression.
Molecular therapy : the journal of the American Society of Gene Therapy
Tatom JB,Wang DB,Dayton RD,Skalli O,Hutton ML,Dickson DW,Klein RL
Wed Apr 01 00:00:00 UTC 2009
Mimicking aspects of frontotemporal lobar degeneration and Lou Gehrig's disease in rats via TDP-43 overexpression.
Molecular therapy : the journal of the American Society of Gene Therapy
Tatom JB,Wang DB,Dayton RD,Skalli O,Hutton ML,Dickson DW,Klein RL
Wed Apr 01 00:00:00 UTC 2009
Mimicking aspects of frontotemporal lobar degeneration and Lou Gehrig's disease in rats via TDP-43 overexpression.
Molecular therapy : the journal of the American Society of Gene Therapy
Tatom JB,Wang DB,Dayton RD,Skalli O,Hutton ML,Dickson DW,Klein RL
Wed Apr 01 00:00:00 UTC 2009
TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration.
Proceedings of the National Academy of Sciences of the United States of America
Wegorzewska I,Bell S,Cairns NJ,Miller TM,Baloh RH
Tue Nov 03 00:00:00 UTC 2009
TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration.
Proceedings of the National Academy of Sciences of the United States of America
Wegorzewska I,Bell S,Cairns NJ,Miller TM,Baloh RH
Tue Nov 03 00:00:00 UTC 2009
TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration.
Proceedings of the National Academy of Sciences of the United States of America
Wegorzewska I,Bell S,Cairns NJ,Miller TM,Baloh RH
Tue Nov 03 00:00:00 UTC 2009
TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration.
Proceedings of the National Academy of Sciences of the United States of America
Wegorzewska I,Bell S,Cairns NJ,Miller TM,Baloh RH
Tue Nov 03 00:00:00 UTC 2009
Clinical heterogeneity in 3 unrelated families linked to VCP p.Arg159His.
Neurology
van der Zee J,Pirici D,Van Langenhove T,Engelborghs S,Vandenberghe R,Hoffmann M,Pusswald G,Van den Broeck M,Peeters K,Mattheijssens M,Martin JJ,De Deyn PP,Cruts M,Haubenberger D,Kumar-Singh S,Zimprich A,Van Broeckhoven C
Tue Aug 25 00:00:00 UTC 2009
Clinical heterogeneity in 3 unrelated families linked to VCP p.Arg159His.
Neurology
van der Zee J,Pirici D,Van Langenhove T,Engelborghs S,Vandenberghe R,Hoffmann M,Pusswald G,Van den Broeck M,Peeters K,Mattheijssens M,Martin JJ,De Deyn PP,Cruts M,Haubenberger D,Kumar-Singh S,Zimprich A,Van Broeckhoven C
Tue Aug 25 00:00:00 UTC 2009
Clinical and pathological characteristics of patients with leucine-rich repeat kinase-2 mutations.
Movement disorders : official journal of the Movement Disorder Society
Covy JP,Yuan W,Waxman EA,Hurtig HI,Van Deerlin VM,Giasson BI
Thu Jan 15 00:00:00 UTC 2009
Clinical and pathological characteristics of patients with leucine-rich repeat kinase-2 mutations.
Movement disorders : official journal of the Movement Disorder Society
Covy JP,Yuan W,Waxman EA,Hurtig HI,Van Deerlin VM,Giasson BI
Thu Jan 15 00:00:00 UTC 2009
Clinical and pathological characteristics of patients with leucine-rich repeat kinase-2 mutations.
Movement disorders : official journal of the Movement Disorder Society
Covy JP,Yuan W,Waxman EA,Hurtig HI,Van Deerlin VM,Giasson BI
Thu Jan 15 00:00:00 UTC 2009
No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism.
Movement disorders : official journal of the Movement Disorder Society
Halliday G,Herrero MT,Murphy K,McCann H,Ros-Bernal F,Barcia C,Mori H,Blesa FJ,Obeso JA
Thu Jul 30 00:00:00 UTC 2009
No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism.
Movement disorders : official journal of the Movement Disorder Society
Halliday G,Herrero MT,Murphy K,McCann H,Ros-Bernal F,Barcia C,Mori H,Blesa FJ,Obeso JA
Thu Jul 30 00:00:00 UTC 2009
Deep brain stimulation in dystonia: sonographic monitoring of electrode placement into the globus pallidus internus.
Movement disorders : official journal of the Movement Disorder Society
Walter U,Wolters A,Wittstock M,Benecke R,Schroeder HW,Müller JU
Thu Jul 30 00:00:00 UTC 2009
Deep brain stimulation in dystonia: sonographic monitoring of electrode placement into the globus pallidus internus.
Movement disorders : official journal of the Movement Disorder Society
Walter U,Wolters A,Wittstock M,Benecke R,Schroeder HW,Müller JU
Thu Jul 30 00:00:00 UTC 2009
TARDBP variation associated with frontotemporal dementia, supranuclear gaze palsy, and chorea.
Movement disorders : official journal of the Movement Disorder Society
Kovacs GG,Murrell JR,Horvath S,Haraszti L,Majtenyi K,Molnar MJ,Budka H,Ghetti B,Spina S
Tue Sep 15 00:00:00 UTC 2009
TARDBP variation associated with frontotemporal dementia, supranuclear gaze palsy, and chorea.
Movement disorders : official journal of the Movement Disorder Society
Kovacs GG,Murrell JR,Horvath S,Haraszti L,Majtenyi K,Molnar MJ,Budka H,Ghetti B,Spina S
Tue Sep 15 00:00:00 UTC 2009
Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease.
The Journal of cell biology
Ju JS,Fuentealba RA,Miller SE,Jackson E,Piwnica-Worms D,Baloh RH,Weihl CC
Mon Dec 14 00:00:00 UTC 2009
Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease.
The Journal of cell biology
Ju JS,Fuentealba RA,Miller SE,Jackson E,Piwnica-Worms D,Baloh RH,Weihl CC
Mon Dec 14 00:00:00 UTC 2009
Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease.
The Journal of cell biology
Ju JS,Fuentealba RA,Miller SE,Jackson E,Piwnica-Worms D,Baloh RH,Weihl CC
Mon Dec 14 00:00:00 UTC 2009
Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease.
The Journal of cell biology
Ju JS,Fuentealba RA,Miller SE,Jackson E,Piwnica-Worms D,Baloh RH,Weihl CC
Mon Dec 14 00:00:00 UTC 2009
Chemical manipulation of hsp70 ATPase activity regulates tau stability.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Jinwal UK,Miyata Y,Koren J,Jones JR,Trotter JH,Chang L,O'Leary J,Morgan D,Lee DC,Shults CL,Rousaki A,Weeber EJ,Zuiderweg ER,Gestwicki JE,Dickey CA
Wed Sep 30 00:00:00 UTC 2009
Chemical manipulation of hsp70 ATPase activity regulates tau stability.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Jinwal UK,Miyata Y,Koren J,Jones JR,Trotter JH,Chang L,O'Leary J,Morgan D,Lee DC,Shults CL,Rousaki A,Weeber EJ,Zuiderweg ER,Gestwicki JE,Dickey CA
Wed Sep 30 00:00:00 UTC 2009
TDP-43 neuropathology is similar in sporadic amyotrophic lateral sclerosis with or without TDP-43 mutations.
Neuropathology and applied neurobiology
Pamphlett R,Luquin N,McLean C,Jew SK,Adams L
Wed Apr 01 00:00:00 UTC 2009
TDP-43 neuropathology is similar in sporadic amyotrophic lateral sclerosis with or without TDP-43 mutations.
Neuropathology and applied neurobiology
Pamphlett R,Luquin N,McLean C,Jew SK,Adams L
Wed Apr 01 00:00:00 UTC 2009
The dorsal raphe nucleus shows phospho-tau neurofibrillary changes before the transentorhinal region in Alzheimer's disease. A precocious onset?
Neuropathology and applied neurobiology
Grinberg LT,Rüb U,Ferretti RE,Nitrini R,Farfel JM,Polichiso L,Gierga K,Jacob-Filho W,Heinsen H
Sat Aug 01 00:00:00 UTC 2009
The dorsal raphe nucleus shows phospho-tau neurofibrillary changes before the transentorhinal region in Alzheimer's disease. A precocious onset?
Neuropathology and applied neurobiology
Grinberg LT,Rüb U,Ferretti RE,Nitrini R,Farfel JM,Polichiso L,Gierga K,Jacob-Filho W,Heinsen H
Sat Aug 01 00:00:00 UTC 2009
Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin.
Journal of neurochemistry
Dormann D,Capell A,Carlson AM,Shankaran SS,Rodde R,Neumann M,Kremmer E,Matsuwaki T,Yamanouchi K,Nishihara M,Haass C
Sat Aug 01 00:00:00 UTC 2009
Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin.
Journal of neurochemistry
Dormann D,Capell A,Carlson AM,Shankaran SS,Rodde R,Neumann M,Kremmer E,Matsuwaki T,Yamanouchi K,Nishihara M,Haass C
Sat Aug 01 00:00:00 UTC 2009
Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin.
Journal of neurochemistry
Dormann D,Capell A,Carlson AM,Shankaran SS,Rodde R,Neumann M,Kremmer E,Matsuwaki T,Yamanouchi K,Nishihara M,Haass C
Sat Aug 01 00:00:00 UTC 2009
Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin.
Journal of neurochemistry
Dormann D,Capell A,Carlson AM,Shankaran SS,Rodde R,Neumann M,Kremmer E,Matsuwaki T,Yamanouchi K,Nishihara M,Haass C
Sat Aug 01 00:00:00 UTC 2009
TDP-43 is recruited to stress granules in conditions of oxidative insult.
Journal of neurochemistry
Colombrita C,Zennaro E,Fallini C,Weber M,Sommacal A,Buratti E,Silani V,Ratti A
Sun Nov 01 00:00:00 UTC 2009
TDP-43 is recruited to stress granules in conditions of oxidative insult.
Journal of neurochemistry
Colombrita C,Zennaro E,Fallini C,Weber M,Sommacal A,Buratti E,Silani V,Ratti A
Sun Nov 01 00:00:00 UTC 2009
TDP-43 is recruited to stress granules in conditions of oxidative insult.
Journal of neurochemistry
Colombrita C,Zennaro E,Fallini C,Weber M,Sommacal A,Buratti E,Silani V,Ratti A
Sun Nov 01 00:00:00 UTC 2009
TDP-43 is recruited to stress granules in conditions of oxidative insult.
Journal of neurochemistry
Colombrita C,Zennaro E,Fallini C,Weber M,Sommacal A,Buratti E,Silani V,Ratti A
Sun Nov 01 00:00:00 UTC 2009
Ubiquitin associated protein 1 is a risk factor for frontotemporal lobar degeneration.
Neurobiology of aging
Rollinson S,Rizzu P,Sikkink S,Baker M,Halliwell N,Snowden J,Traynor BJ,Ruano D,Cairns N,Rohrer JD,Mead S,Collinge J,Rossor M,Akay E,Guerreiro R,Rademakers R,Morrison KE,Pastor P,Alonso E,Martinez-Lage P,Graff-Radford N,Neary D,Heutink P,Mann DM,Van Swieten J,Pickering-Brown SM
Wed Apr 01 00:00:00 UTC 2009
Ubiquitin associated protein 1 is a risk factor for frontotemporal lobar degeneration.
Neurobiology of aging
Rollinson S,Rizzu P,Sikkink S,Baker M,Halliwell N,Snowden J,Traynor BJ,Ruano D,Cairns N,Rohrer JD,Mead S,Collinge J,Rossor M,Akay E,Guerreiro R,Rademakers R,Morrison KE,Pastor P,Alonso E,Martinez-Lage P,Graff-Radford N,Neary D,Heutink P,Mann DM,Van Swieten J,Pickering-Brown SM
Wed Apr 01 00:00:00 UTC 2009
Prominent phenotypic variability associated with mutations in Progranulin.
Neurobiology of aging
Kelley BJ,Haidar W,Boeve BF,Baker M,Graff-Radford NR,Krefft T,Frank AR,Jack CR,Shiung M,Knopman DS,Josephs KA,Parashos SA,Rademakers R,Hutton M,Pickering-Brown S,Adamson J,Kuntz KM,Dickson DW,Parisi JE,Smith GE,Ivnik RJ,Petersen RC
Fri May 01 00:00:00 UTC 2009
Prominent phenotypic variability associated with mutations in Progranulin.
Neurobiology of aging
Kelley BJ,Haidar W,Boeve BF,Baker M,Graff-Radford NR,Krefft T,Frank AR,Jack CR,Shiung M,Knopman DS,Josephs KA,Parashos SA,Rademakers R,Hutton M,Pickering-Brown S,Adamson J,Kuntz KM,Dickson DW,Parisi JE,Smith GE,Ivnik RJ,Petersen RC
Fri May 01 00:00:00 UTC 2009
Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43.
Human molecular genetics
Nonaka T,Kametani F,Arai T,Akiyama H,Hasegawa M
Tue Sep 15 00:00:00 UTC 2009
Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43.
Human molecular genetics
Nonaka T,Kametani F,Arai T,Akiyama H,Hasegawa M
Tue Sep 15 00:00:00 UTC 2009
Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43.
Human molecular genetics
Nonaka T,Kametani F,Arai T,Akiyama H,Hasegawa M
Tue Sep 15 00:00:00 UTC 2009
Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43.
Human molecular genetics
Nonaka T,Kametani F,Arai T,Akiyama H,Hasegawa M
Tue Sep 15 00:00:00 UTC 2009
Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43.
Human molecular genetics
Nonaka T,Kametani F,Arai T,Akiyama H,Hasegawa M
Tue Sep 15 00:00:00 UTC 2009
Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43.
Human molecular genetics
Nonaka T,Kametani F,Arai T,Akiyama H,Hasegawa M
Tue Sep 15 00:00:00 UTC 2009
TDP-43 is not present in brain tissue of patients with schizophrenia.
Schizophrenia research
Mateen FJ,Josephs KA
Sun Mar 01 00:00:00 UTC 2009
TDP-43 is not present in brain tissue of patients with schizophrenia.
Schizophrenia research
Mateen FJ,Josephs KA
Sun Mar 01 00:00:00 UTC 2009
Inflammatory myopathies with mitochondrial pathology and protein aggregates.
Journal of the neurological sciences
Temiz P,Weihl CC,Pestronk A
Sun Mar 15 00:00:00 UTC 2009
Inflammatory myopathies with mitochondrial pathology and protein aggregates.
Journal of the neurological sciences
Temiz P,Weihl CC,Pestronk A
Sun Mar 15 00:00:00 UTC 2009
Pallidonigral TDP-43 pathology in Perry syndrome.
Parkinsonism & related disorders
Wider C,Dickson DW,Stoessl AJ,Tsuboi Y,Chapon F,Gutmann L,Lechevalier B,Calne DB,Personett DA,Hulihan M,Kachergus J,Rademakers R,Baker MC,Grantier LL,Sujith OK,Brown L,Calne S,Farrer MJ,Wszolek ZK
Fri May 01 00:00:00 UTC 2009
Pallidonigral TDP-43 pathology in Perry syndrome.
Parkinsonism & related disorders
Wider C,Dickson DW,Stoessl AJ,Tsuboi Y,Chapon F,Gutmann L,Lechevalier B,Calne DB,Personett DA,Hulihan M,Kachergus J,Rademakers R,Baker MC,Grantier LL,Sujith OK,Brown L,Calne S,Farrer MJ,Wszolek ZK
Fri May 01 00:00:00 UTC 2009
Pallidonigral TDP-43 pathology in Perry syndrome.
Parkinsonism & related disorders
Wider C,Dickson DW,Stoessl AJ,Tsuboi Y,Chapon F,Gutmann L,Lechevalier B,Calne DB,Personett DA,Hulihan M,Kachergus J,Rademakers R,Baker MC,Grantier LL,Sujith OK,Brown L,Calne S,Farrer MJ,Wszolek ZK
Fri May 01 00:00:00 UTC 2009
Pallidonigral TDP-43 pathology in Perry syndrome.
Parkinsonism & related disorders
Wider C,Dickson DW,Stoessl AJ,Tsuboi Y,Chapon F,Gutmann L,Lechevalier B,Calne DB,Personett DA,Hulihan M,Kachergus J,Rademakers R,Baker MC,Grantier LL,Sujith OK,Brown L,Calne S,Farrer MJ,Wszolek ZK
Fri May 01 00:00:00 UTC 2009
Phosphorylated and ubiquitinated TDP-43 pathological inclusions in ALS and FTLD-U are recapitulated in SH-SY5Y cells.
FEBS letters
Nonaka T,Arai T,Buratti E,Baralle FE,Akiyama H,Hasegawa M
Thu Jan 22 00:00:00 UTC 2009
Phosphorylated and ubiquitinated TDP-43 pathological inclusions in ALS and FTLD-U are recapitulated in SH-SY5Y cells.
FEBS letters
Nonaka T,Arai T,Buratti E,Baralle FE,Akiyama H,Hasegawa M
Thu Jan 22 00:00:00 UTC 2009
Phosphorylated and ubiquitinated TDP-43 pathological inclusions in ALS and FTLD-U are recapitulated in SH-SY5Y cells.
FEBS letters
Nonaka T,Arai T,Buratti E,Baralle FE,Akiyama H,Hasegawa M
Thu Jan 22 00:00:00 UTC 2009
Phosphorylated and ubiquitinated TDP-43 pathological inclusions in ALS and FTLD-U are recapitulated in SH-SY5Y cells.
FEBS letters
Nonaka T,Arai T,Buratti E,Baralle FE,Akiyama H,Hasegawa M
Thu Jan 22 00:00:00 UTC 2009
Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models.
FEBS letters
Yamashita M,Nonaka T,Arai T,Kametani F,Buchman VL,Ninkina N,Bachurin SO,Akiyama H,Goedert M,Hasegawa M
Tue Jul 21 00:00:00 UTC 2009
Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models.
FEBS letters
Yamashita M,Nonaka T,Arai T,Kametani F,Buchman VL,Ninkina N,Bachurin SO,Akiyama H,Goedert M,Hasegawa M
Tue Jul 21 00:00:00 UTC 2009
Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models.
FEBS letters
Yamashita M,Nonaka T,Arai T,Kametani F,Buchman VL,Ninkina N,Bachurin SO,Akiyama H,Goedert M,Hasegawa M
Tue Jul 21 00:00:00 UTC 2009
Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models.
FEBS letters
Yamashita M,Nonaka T,Arai T,Kametani F,Buchman VL,Ninkina N,Bachurin SO,Akiyama H,Goedert M,Hasegawa M
Tue Jul 21 00:00:00 UTC 2009
Sarcoplasmic redistribution of nuclear TDP-43 in inclusion body myositis.
Muscle & nerve
Salajegheh M,Pinkus JL,Taylor JP,Amato AA,Nazareno R,Baloh RH,Greenberg SA
Wed Jul 01 00:00:00 UTC 2009
Sarcoplasmic redistribution of nuclear TDP-43 in inclusion body myositis.
Muscle & nerve
Salajegheh M,Pinkus JL,Taylor JP,Amato AA,Nazareno R,Baloh RH,Greenberg SA
Wed Jul 01 00:00:00 UTC 2009
Sarcoplasmic redistribution of nuclear TDP-43 in inclusion body myositis.
Muscle & nerve
Salajegheh M,Pinkus JL,Taylor JP,Amato AA,Nazareno R,Baloh RH,Greenberg SA
Wed Jul 01 00:00:00 UTC 2009
Sarcoplasmic redistribution of nuclear TDP-43 in inclusion body myositis.
Muscle & nerve
Salajegheh M,Pinkus JL,Taylor JP,Amato AA,Nazareno R,Baloh RH,Greenberg SA
Wed Jul 01 00:00:00 UTC 2009
Sarcoplasmic redistribution of nuclear TDP-43 in inclusion body myositis.
Muscle & nerve
Salajegheh M,Pinkus JL,Taylor JP,Amato AA,Nazareno R,Baloh RH,Greenberg SA
Wed Jul 01 00:00:00 UTC 2009
Axonal ligation induces transient redistribution of TDP-43 in brainstem motor neurons.
Neuroscience
Sato T,Takeuchi S,Saito A,Ding W,Bamba H,Matsuura H,Hisa Y,Tooyama I,Urushitani M
Tue Dec 29 00:00:00 UTC 2009
Axonal ligation induces transient redistribution of TDP-43 in brainstem motor neurons.
Neuroscience
Sato T,Takeuchi S,Saito A,Ding W,Bamba H,Matsuura H,Hisa Y,Tooyama I,Urushitani M
Tue Dec 29 00:00:00 UTC 2009
Axonal ligation induces transient redistribution of TDP-43 in brainstem motor neurons.
Neuroscience
Sato T,Takeuchi S,Saito A,Ding W,Bamba H,Matsuura H,Hisa Y,Tooyama I,Urushitani M
Tue Dec 29 00:00:00 UTC 2009
Axonal ligation induces transient redistribution of TDP-43 in brainstem motor neurons.
Neuroscience
Sato T,Takeuchi S,Saito A,Ding W,Bamba H,Matsuura H,Hisa Y,Tooyama I,Urushitani M
Tue Dec 29 00:00:00 UTC 2009
Wobbler mice modeling motor neuron disease display elevated transactive response DNA binding protein.
Neuroscience
Dennis JS,Citron BA
Fri Jan 23 00:00:00 UTC 2009
Wobbler mice modeling motor neuron disease display elevated transactive response DNA binding protein.
Neuroscience
Dennis JS,Citron BA
Fri Jan 23 00:00:00 UTC 2009
Cytosolic TDP-43 expression following axotomy is associated with caspase 3 activation in NFL-/- mice: support for a role for TDP-43 in the physiological response to neuronal injury.
Brain research
Moisse K,Mepham J,Volkening K,Welch I,Hill T,Strong MJ
Tue Nov 03 00:00:00 UTC 2009
Cytosolic TDP-43 expression following axotomy is associated with caspase 3 activation in NFL-/- mice: support for a role for TDP-43 in the physiological response to neuronal injury.
Brain research
Moisse K,Mepham J,Volkening K,Welch I,Hill T,Strong MJ
Tue Nov 03 00:00:00 UTC 2009
Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS).
Brain research
Volkening K,Leystra-Lantz C,Yang W,Jaffee H,Strong MJ
Fri Dec 11 00:00:00 UTC 2009
Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS).
Brain research
Volkening K,Leystra-Lantz C,Yang W,Jaffee H,Strong MJ
Fri Dec 11 00:00:00 UTC 2009
Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS).
Brain research
Volkening K,Leystra-Lantz C,Yang W,Jaffee H,Strong MJ
Fri Dec 11 00:00:00 UTC 2009
Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS).
Brain research
Volkening K,Leystra-Lantz C,Yang W,Jaffee H,Strong MJ
Fri Dec 11 00:00:00 UTC 2009
Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS).
Brain research
Volkening K,Leystra-Lantz C,Yang W,Jaffee H,Strong MJ
Fri Dec 11 00:00:00 UTC 2009
Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS).
Brain research
Volkening K,Leystra-Lantz C,Yang W,Jaffee H,Strong MJ
Fri Dec 11 00:00:00 UTC 2009
Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axotomy: implications for TDP-43 in the physiological response to neuronal injury.
Brain research
Moisse K,Volkening K,Leystra-Lantz C,Welch I,Hill T,Strong MJ
Fri Jan 16 00:00:00 UTC 2009
Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axotomy: implications for TDP-43 in the physiological response to neuronal injury.
Brain research
Moisse K,Volkening K,Leystra-Lantz C,Welch I,Hill T,Strong MJ
Fri Jan 16 00:00:00 UTC 2009
Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axotomy: implications for TDP-43 in the physiological response to neuronal injury.
Brain research
Moisse K,Volkening K,Leystra-Lantz C,Welch I,Hill T,Strong MJ
Fri Jan 16 00:00:00 UTC 2009
Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axotomy: implications for TDP-43 in the physiological response to neuronal injury.
Brain research
Moisse K,Volkening K,Leystra-Lantz C,Welch I,Hill T,Strong MJ
Fri Jan 16 00:00:00 UTC 2009
Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axotomy: implications for TDP-43 in the physiological response to neuronal injury.
Brain research
Moisse K,Volkening K,Leystra-Lantz C,Welch I,Hill T,Strong MJ
Fri Jan 16 00:00:00 UTC 2009
Neuropathological investigation of regions responsible for semantic aphasia in frontotemporal lobar degeneration.
Dementia and geriatric cognitive disorders
Yamamoto R,Iseki E,Higashi S,Murayama N,Minegishi M,Sato K,Hino H,Fujisawa K,Kosaka K,Togo T,Katsuse O,Uchikado H,Furukawa Y,Yoshida M,Hashizume Y,Arai H
Thu May 28 00:00:00 UTC 2009
Neuropathological investigation of regions responsible for semantic aphasia in frontotemporal lobar degeneration.
Dementia and geriatric cognitive disorders
Yamamoto R,Iseki E,Higashi S,Murayama N,Minegishi M,Sato K,Hino H,Fujisawa K,Kosaka K,Togo T,Katsuse O,Uchikado H,Furukawa Y,Yoshida M,Hashizume Y,Arai H
Thu May 28 00:00:00 UTC 2009
TDP-43 localizes in mRNA transcription and processing sites in mammalian neurons.
Journal of structural biology
Casafont I,Bengoechea R,Tapia O,Berciano MT,Lafarga M
Tue Sep 01 00:00:00 UTC 2009
TDP-43 localizes in mRNA transcription and processing sites in mammalian neurons.
Journal of structural biology
Casafont I,Bengoechea R,Tapia O,Berciano MT,Lafarga M
Tue Sep 01 00:00:00 UTC 2009
TDP-43 localizes in mRNA transcription and processing sites in mammalian neurons.
Journal of structural biology
Casafont I,Bengoechea R,Tapia O,Berciano MT,Lafarga M
Tue Sep 01 00:00:00 UTC 2009
TDP-43 localizes in mRNA transcription and processing sites in mammalian neurons.
Journal of structural biology
Casafont I,Bengoechea R,Tapia O,Berciano MT,Lafarga M
Tue Sep 01 00:00:00 UTC 2009
Phosphorylation-dependent TDP-43 antibody detects intraneuronal dot-like structures showing morphological characters of granulovacuolar degeneration.
Neuroscience letters
Kadokura A,Yamazaki T,Kakuda S,Makioka K,Lemere CA,Fujita Y,Takatama M,Okamoto K
Tue Sep 29 00:00:00 UTC 2009
Phosphorylation-dependent TDP-43 antibody detects intraneuronal dot-like structures showing morphological characters of granulovacuolar degeneration.
Neuroscience letters
Kadokura A,Yamazaki T,Kakuda S,Makioka K,Lemere CA,Fujita Y,Takatama M,Okamoto K
Tue Sep 29 00:00:00 UTC 2009
Phosphorylation-dependent TDP-43 antibody detects intraneuronal dot-like structures showing morphological characters of granulovacuolar degeneration.
Neuroscience letters
Kadokura A,Yamazaki T,Kakuda S,Makioka K,Lemere CA,Fujita Y,Takatama M,Okamoto K
Tue Sep 29 00:00:00 UTC 2009
Phosphorylation-dependent TDP-43 antibody detects intraneuronal dot-like structures showing morphological characters of granulovacuolar degeneration.
Neuroscience letters
Kadokura A,Yamazaki T,Kakuda S,Makioka K,Lemere CA,Fujita Y,Takatama M,Okamoto K
Tue Sep 29 00:00:00 UTC 2009
Phosphorylation-dependent TDP-43 antibody detects intraneuronal dot-like structures showing morphological characters of granulovacuolar degeneration.
Neuroscience letters
Kadokura A,Yamazaki T,Kakuda S,Makioka K,Lemere CA,Fujita Y,Takatama M,Okamoto K
Tue Sep 29 00:00:00 UTC 2009
Mislocalization of TDP-43 in the G93A mutant SOD1 transgenic mouse model of ALS.
Neuroscience letters
Shan X,Vocadlo D,Krieger C
Fri Jul 17 00:00:00 UTC 2009
Mislocalization of TDP-43 in the G93A mutant SOD1 transgenic mouse model of ALS.
Neuroscience letters
Shan X,Vocadlo D,Krieger C
Fri Jul 17 00:00:00 UTC 2009
Mislocalization of TDP-43 in the G93A mutant SOD1 transgenic mouse model of ALS.
Neuroscience letters
Shan X,Vocadlo D,Krieger C
Fri Jul 17 00:00:00 UTC 2009
Mislocalization of TDP-43 in the G93A mutant SOD1 transgenic mouse model of ALS.
Neuroscience letters
Shan X,Vocadlo D,Krieger C
Fri Jul 17 00:00:00 UTC 2009
Decreased cystatin C immunoreactivity in spinal motor neurons and astrocytes in amyotrophic lateral sclerosis.
Journal of neuropathology and experimental neurology
Mori F,Tanji K,Miki Y,Wakabayashi K
Sun Nov 01 00:00:00 UTC 2009
Decreased cystatin C immunoreactivity in spinal motor neurons and astrocytes in amyotrophic lateral sclerosis.
Journal of neuropathology and experimental neurology
Mori F,Tanji K,Miki Y,Wakabayashi K
Sun Nov 01 00:00:00 UTC 2009
Nuclear TAR DNA binding protein 43 expression in spinal cord neurons correlates with the clinical course in amyotrophic lateral sclerosis.
Journal of neuropathology and experimental neurology
Sumi H,Kato S,Mochimaru Y,Fujimura H,Etoh M,Sakoda S
Thu Jan 01 00:00:00 UTC 2009
Nuclear TAR DNA binding protein 43 expression in spinal cord neurons correlates with the clinical course in amyotrophic lateral sclerosis.
Journal of neuropathology and experimental neurology
Sumi H,Kato S,Mochimaru Y,Fujimura H,Etoh M,Sakoda S
Thu Jan 01 00:00:00 UTC 2009
Transactivation response DNA-binding protein 43 microvasculopathy in frontotemporal degeneration and familial Lewy body disease.
Journal of neuropathology and experimental neurology
Lin WL,Castanedes-Casey M,Dickson DW
Sun Nov 01 00:00:00 UTC 2009
Transactivation response DNA-binding protein 43 microvasculopathy in frontotemporal degeneration and familial Lewy body disease.
Journal of neuropathology and experimental neurology
Lin WL,Castanedes-Casey M,Dickson DW
Sun Nov 01 00:00:00 UTC 2009
Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease.
Journal of neuropathology and experimental neurology
Higashi S,Moore DJ,Yamamoto R,Minegishi M,Sato K,Togo T,Katsuse O,Uchikado H,Furukawa Y,Hino H,Kosaka K,Emson PC,Wada K,Dawson VL,Dawson TM,Arai H,Iseki E
Tue Sep 01 00:00:00 UTC 2009
Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease.
Journal of neuropathology and experimental neurology
Higashi S,Moore DJ,Yamamoto R,Minegishi M,Sato K,Togo T,Katsuse O,Uchikado H,Furukawa Y,Hino H,Kosaka K,Emson PC,Wada K,Dawson VL,Dawson TM,Arai H,Iseki E
Tue Sep 01 00:00:00 UTC 2009
Regional distribution of TDP-43 inclusions in Alzheimer disease (AD) brains: their relation to AD common pathology.
Neuropathology : official journal of the Japanese Society of Neuropathology
Kadokura A,Yamazaki T,Lemere CA,Takatama M,Okamoto K
Thu Oct 01 00:00:00 UTC 2009
Regional distribution of TDP-43 inclusions in Alzheimer disease (AD) brains: their relation to AD common pathology.
Neuropathology : official journal of the Japanese Society of Neuropathology
Kadokura A,Yamazaki T,Lemere CA,Takatama M,Okamoto K
Thu Oct 01 00:00:00 UTC 2009
Regional distribution of TDP-43 inclusions in Alzheimer disease (AD) brains: their relation to AD common pathology.
Neuropathology : official journal of the Japanese Society of Neuropathology
Kadokura A,Yamazaki T,Lemere CA,Takatama M,Okamoto K
Thu Oct 01 00:00:00 UTC 2009
Frontotemporal lobar degeneration with ubiquitinated tau-negative inclusions and additional alpha-synuclein pathology but also unusual cerebellar ubiquitinated p62-positive, TDP-43-negative inclusions.
Neuropathology : official journal of the Japanese Society of Neuropathology
King A,Al-Sarraj S,Shaw C
Sat Aug 01 00:00:00 UTC 2009
Frontotemporal lobar degeneration with ubiquitinated tau-negative inclusions and additional alpha-synuclein pathology but also unusual cerebellar ubiquitinated p62-positive, TDP-43-negative inclusions.
Neuropathology : official journal of the Japanese Society of Neuropathology
King A,Al-Sarraj S,Shaw C
Sat Aug 01 00:00:00 UTC 2009
Sporadic amyotrophic lateral sclerosis: Widespread multisystem degeneration with TDP-43 pathology in a patient after long-term survival on a respirator.
Neuropathology : official journal of the Japanese Society of Neuropathology
Nishihira Y,Tan CF,Toyoshima Y,Yonemochi Y,Kondo H,Nakajima T,Takahashi H
Tue Dec 01 00:00:00 UTC 2009
Sporadic amyotrophic lateral sclerosis: Widespread multisystem degeneration with TDP-43 pathology in a patient after long-term survival on a respirator.
Neuropathology : official journal of the Japanese Society of Neuropathology
Nishihira Y,Tan CF,Toyoshima Y,Yonemochi Y,Kondo H,Nakajima T,Takahashi H
Tue Dec 01 00:00:00 UTC 2009
TDP-43 is consistently co-localized with ubiquitinated inclusions in sporadic and Guam amyotrophic lateral sclerosis but not in familial amyotrophic lateral sclerosis with and without SOD1 mutations.
Neuropathology : official journal of the Japanese Society of Neuropathology
Maekawa S,Leigh PN,King A,Jones E,Steele JC,Bodi I,Shaw CE,Hortobagyi T,Al-Sarraj S
Tue Dec 01 00:00:00 UTC 2009
TDP-43 is consistently co-localized with ubiquitinated inclusions in sporadic and Guam amyotrophic lateral sclerosis but not in familial amyotrophic lateral sclerosis with and without SOD1 mutations.
Neuropathology : official journal of the Japanese Society of Neuropathology
Maekawa S,Leigh PN,King A,Jones E,Steele JC,Bodi I,Shaw CE,Hortobagyi T,Al-Sarraj S
Tue Dec 01 00:00:00 UTC 2009
Absence of Pittsburgh compound B detection of cerebral amyloid beta in a patient with clinical, cognitive, and cerebrospinal fluid markers of Alzheimer disease: a case report.
Archives of neurology
Cairns NJ,Ikonomovic MD,Benzinger T,Storandt M,Fagan AM,Shah AR,Reinwald LT,Carter D,Felton A,Holtzman DM,Mintun MA,Klunk WE,Morris JC
Tue Dec 01 00:00:00 UTC 2009
Absence of Pittsburgh compound B detection of cerebral amyloid beta in a patient with clinical, cognitive, and cerebrospinal fluid markers of Alzheimer disease: a case report.
Archives of neurology
Cairns NJ,Ikonomovic MD,Benzinger T,Storandt M,Fagan AM,Shah AR,Reinwald LT,Carter D,Felton A,Holtzman DM,Mintun MA,Klunk WE,Morris JC
Tue Dec 01 00:00:00 UTC 2009
Rapidly progressive neurodegenerative dementias.
Archives of neurology
Josephs KA,Ahlskog JE,Parisi JE,Boeve BF,Crum BA,Giannini C,Petersen RC
Sun Feb 01 00:00:00 UTC 2009
Rapidly progressive neurodegenerative dementias.
Archives of neurology
Josephs KA,Ahlskog JE,Parisi JE,Boeve BF,Crum BA,Giannini C,Petersen RC
Sun Feb 01 00:00:00 UTC 2009
Potentiation of amyotrophic lateral sclerosis (ALS)-associated TDP-43 aggregation by the proteasome-targeting factor, ubiquilin 1.
The Journal of biological chemistry
Kim SH,Shi Y,Hanson KA,Williams LM,Sakasai R,Bowler MJ,Tibbetts RS
Fri Mar 20 00:00:00 UTC 2009
Potentiation of amyotrophic lateral sclerosis (ALS)-associated TDP-43 aggregation by the proteasome-targeting factor, ubiquilin 1.
The Journal of biological chemistry
Kim SH,Shi Y,Hanson KA,Williams LM,Sakasai R,Bowler MJ,Tibbetts RS
Fri Mar 20 00:00:00 UTC 2009
Potentiation of amyotrophic lateral sclerosis (ALS)-associated TDP-43 aggregation by the proteasome-targeting factor, ubiquilin 1.
The Journal of biological chemistry
Kim SH,Shi Y,Hanson KA,Williams LM,Sakasai R,Bowler MJ,Tibbetts RS
Fri Mar 20 00:00:00 UTC 2009
Potentiation of amyotrophic lateral sclerosis (ALS)-associated TDP-43 aggregation by the proteasome-targeting factor, ubiquilin 1.
The Journal of biological chemistry
Kim SH,Shi Y,Hanson KA,Williams LM,Sakasai R,Bowler MJ,Tibbetts RS
Fri Mar 20 00:00:00 UTC 2009
Potentiation of amyotrophic lateral sclerosis (ALS)-associated TDP-43 aggregation by the proteasome-targeting factor, ubiquilin 1.
The Journal of biological chemistry
Kim SH,Shi Y,Hanson KA,Williams LM,Sakasai R,Bowler MJ,Tibbetts RS
Fri Mar 20 00:00:00 UTC 2009
Potentiation of amyotrophic lateral sclerosis (ALS)-associated TDP-43 aggregation by the proteasome-targeting factor, ubiquilin 1.
The Journal of biological chemistry
Kim SH,Shi Y,Hanson KA,Williams LM,Sakasai R,Bowler MJ,Tibbetts RS
Fri Mar 20 00:00:00 UTC 2009
Frontotemporal dementia and amyotrophic lateral sclerosis-associated disease protein TDP-43 promotes dendritic branching.
Molecular brain
Lu Y,Ferris J,Gao FB
Fri Sep 25 00:00:00 UTC 2009
Frontotemporal dementia and amyotrophic lateral sclerosis-associated disease protein TDP-43 promotes dendritic branching.
Molecular brain
Lu Y,Ferris J,Gao FB
Fri Sep 25 00:00:00 UTC 2009
Progranulin is expressed within motor neurons and promotes neuronal cell survival.
BMC neuroscience
Ryan CL,Baranowski DC,Chitramuthu BP,Malik S,Li Z,Cao M,Minotti S,Durham HD,Kay DG,Shaw CA,Bennett HP,Bateman A
Tue Oct 27 00:00:00 UTC 2009
VCP mutations causing frontotemporal lobar degeneration disrupt localization of TDP-43 and induce cell death.
The Journal of biological chemistry
Gitcho MA,Strider J,Carter D,Taylor-Reinwald L,Forman MS,Goate AM,Cairns NJ
Fri May 01 00:00:00 UTC 2009
VCP mutations causing frontotemporal lobar degeneration disrupt localization of TDP-43 and induce cell death.
The Journal of biological chemistry
Gitcho MA,Strider J,Carter D,Taylor-Reinwald L,Forman MS,Goate AM,Cairns NJ
Fri May 01 00:00:00 UTC 2009
VCP mutations causing frontotemporal lobar degeneration disrupt localization of TDP-43 and induce cell death.
The Journal of biological chemistry
Gitcho MA,Strider J,Carter D,Taylor-Reinwald L,Forman MS,Goate AM,Cairns NJ
Fri May 01 00:00:00 UTC 2009
VCP mutations causing frontotemporal lobar degeneration disrupt localization of TDP-43 and induce cell death.
The Journal of biological chemistry
Gitcho MA,Strider J,Carter D,Taylor-Reinwald L,Forman MS,Goate AM,Cairns NJ
Fri May 01 00:00:00 UTC 2009
VCP mutations causing frontotemporal lobar degeneration disrupt localization of TDP-43 and induce cell death.
The Journal of biological chemistry
Gitcho MA,Strider J,Carter D,Taylor-Reinwald L,Forman MS,Goate AM,Cairns NJ
Fri May 01 00:00:00 UTC 2009
Clinical and pathological continuum of multisystem TDP-43 proteinopathies.
Archives of neurology
Geser F,Martinez-Lage M,Robinson J,Uryu K,Neumann M,Brandmeir NJ,Xie SX,Kwong LK,Elman L,McCluskey L,Clark CM,Malunda J,Miller BL,Zimmerman EA,Qian J,Van Deerlin V,Grossman M,Lee VM,Trojanowski JQ
Sun Feb 01 00:00:00 UTC 2009
Clinical and pathological continuum of multisystem TDP-43 proteinopathies.
Archives of neurology
Geser F,Martinez-Lage M,Robinson J,Uryu K,Neumann M,Brandmeir NJ,Xie SX,Kwong LK,Elman L,McCluskey L,Clark CM,Malunda J,Miller BL,Zimmerman EA,Qian J,Van Deerlin V,Grossman M,Lee VM,Trojanowski JQ
Sun Feb 01 00:00:00 UTC 2009
Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies.
The Journal of biological chemistry
Igaz LM,Kwong LK,Chen-Plotkin A,Winton MJ,Unger TL,Xu Y,Neumann M,Trojanowski JQ,Lee VM
Fri Mar 27 00:00:00 UTC 2009
Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies.
The Journal of biological chemistry
Igaz LM,Kwong LK,Chen-Plotkin A,Winton MJ,Unger TL,Xu Y,Neumann M,Trojanowski JQ,Lee VM
Fri Mar 27 00:00:00 UTC 2009
Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies.
The Journal of biological chemistry
Igaz LM,Kwong LK,Chen-Plotkin A,Winton MJ,Unger TL,Xu Y,Neumann M,Trojanowski JQ,Lee VM
Fri Mar 27 00:00:00 UTC 2009
Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies.
The Journal of biological chemistry
Igaz LM,Kwong LK,Chen-Plotkin A,Winton MJ,Unger TL,Xu Y,Neumann M,Trojanowski JQ,Lee VM
Fri Mar 27 00:00:00 UTC 2009
Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies.
The Journal of biological chemistry
Igaz LM,Kwong LK,Chen-Plotkin A,Winton MJ,Unger TL,Xu Y,Neumann M,Trojanowski JQ,Lee VM
Fri Mar 27 00:00:00 UTC 2009
Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies.
The Journal of biological chemistry
Igaz LM,Kwong LK,Chen-Plotkin A,Winton MJ,Unger TL,Xu Y,Neumann M,Trojanowski JQ,Lee VM
Fri Mar 27 00:00:00 UTC 2009
Transactive response DNA-binding protein 43 burden in familial Alzheimer disease and Down syndrome.
Archives of neurology
Lippa CF,Rosso AL,Stutzbach LD,Neumann M,Lee VM,Trojanowski JQ
Tue Dec 01 00:00:00 UTC 2009
Transactive response DNA-binding protein 43 burden in familial Alzheimer disease and Down syndrome.
Archives of neurology
Lippa CF,Rosso AL,Stutzbach LD,Neumann M,Lee VM,Trojanowski JQ
Tue Dec 01 00:00:00 UTC 2009
TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases.
The Journal of biological chemistry
Iguchi Y,Katsuno M,Niwa JI,Yamada SI,Sone J,Waza M,Adachi H,Tanaka F,Nagata KI,Arimura N,Watanabe T,Kaibuchi K,Sobue G
Fri Aug 14 00:00:00 UTC 2009
TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases.
The Journal of biological chemistry
Iguchi Y,Katsuno M,Niwa JI,Yamada SI,Sone J,Waza M,Adachi H,Tanaka F,Nagata KI,Arimura N,Watanabe T,Kaibuchi K,Sobue G
Fri Aug 14 00:00:00 UTC 2009
Abstracts of the 110th Meeting of the British Neuropathological Society. January 7-9, 2009. London, United Kingdom.
Neuropathology and applied neurobiology
No authors listed
Thu Jan 01 00:00:00 UTC 2009
TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis.
Science (New York, N.Y.)
Sreedharan J,Blair IP,Tripathi VB,Hu X,Vance C,Rogelj B,Ackerley S,Durnall JC,Williams KL,Buratti E,Baralle F,de Belleroche J,Mitchell JD,Leigh PN,Al-Chalabi A,Miller CC,Nicholson G,Shaw CE
Fri Mar 21 00:00:00 UTC 2008
TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis.
Science (New York, N.Y.)
Sreedharan J,Blair IP,Tripathi VB,Hu X,Vance C,Rogelj B,Ackerley S,Durnall JC,Williams KL,Buratti E,Baralle F,de Belleroche J,Mitchell JD,Leigh PN,Al-Chalabi A,Miller CC,Nicholson G,Shaw CE
Fri Mar 21 00:00:00 UTC 2008
Progranulin mutation causes frontotemporal dementia in the Swedish Karolinska family.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Chiang HH,Rosvall L,Brohede J,Axelman K,Björk BF,Nennesmo I,Robins T,Graff C
Sat Nov 01 00:00:00 UTC 2008
Progranulin mutation causes frontotemporal dementia in the Swedish Karolinska family.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Chiang HH,Rosvall L,Brohede J,Axelman K,Björk BF,Nennesmo I,Robins T,Graff C
Sat Nov 01 00:00:00 UTC 2008
Ultrastructural localization of TDP-43 in filamentous neuronal inclusions in various neurodegenerative diseases.
Acta neuropathologica
Lin WL,Dickson DW
Fri Aug 01 00:00:00 UTC 2008
Ultrastructural localization of TDP-43 in filamentous neuronal inclusions in various neurodegenerative diseases.
Acta neuropathologica
Lin WL,Dickson DW
Fri Aug 01 00:00:00 UTC 2008
TDP-43 immunoreactivity in anoxic, ischemic and neoplastic lesions of the central nervous system.
Acta neuropathologica
Lee EB,Lee VM,Trojanowski JQ,Neumann M
Sat Mar 01 00:00:00 UTC 2008
TDP-43 immunoreactivity in anoxic, ischemic and neoplastic lesions of the central nervous system.
Acta neuropathologica
Lee EB,Lee VM,Trojanowski JQ,Neumann M
Sat Mar 01 00:00:00 UTC 2008
TDP-43 immunoreactivity in anoxic, ischemic and neoplastic lesions of the central nervous system.
Acta neuropathologica
Lee EB,Lee VM,Trojanowski JQ,Neumann M
Sat Mar 01 00:00:00 UTC 2008
Temporal lobar predominance of TDP-43 neuronal cytoplasmic inclusions in Alzheimer disease.
Acta neuropathologica
Hu WT,Josephs KA,Knopman DS,Boeve BF,Dickson DW,Petersen RC,Parisi JE
Fri Aug 01 00:00:00 UTC 2008
Temporal lobar predominance of TDP-43 neuronal cytoplasmic inclusions in Alzheimer disease.
Acta neuropathologica
Hu WT,Josephs KA,Knopman DS,Boeve BF,Dickson DW,Petersen RC,Parisi JE
Fri Aug 01 00:00:00 UTC 2008
TDP-43 protein in plasma may index TDP-43 brain pathology in Alzheimer's disease and frontotemporal lobar degeneration.
Acta neuropathologica
Foulds P,McAuley E,Gibbons L,Davidson Y,Pickering-Brown SM,Neary D,Snowden JS,Allsop D,Mann DM
Fri Aug 01 00:00:00 UTC 2008
TDP-43 protein in plasma may index TDP-43 brain pathology in Alzheimer's disease and frontotemporal lobar degeneration.
Acta neuropathologica
Foulds P,McAuley E,Gibbons L,Davidson Y,Pickering-Brown SM,Neary D,Snowden JS,Allsop D,Mann DM
Fri Aug 01 00:00:00 UTC 2008
TDP-43 protein in plasma may index TDP-43 brain pathology in Alzheimer's disease and frontotemporal lobar degeneration.
Acta neuropathologica
Foulds P,McAuley E,Gibbons L,Davidson Y,Pickering-Brown SM,Neary D,Snowden JS,Allsop D,Mann DM
Fri Aug 01 00:00:00 UTC 2008
TDP-43 protein in plasma may index TDP-43 brain pathology in Alzheimer's disease and frontotemporal lobar degeneration.
Acta neuropathologica
Foulds P,McAuley E,Gibbons L,Davidson Y,Pickering-Brown SM,Neary D,Snowden JS,Allsop D,Mann DM
Fri Aug 01 00:00:00 UTC 2008
LRRK2 and parkin immunoreactivity in multiple system atrophy inclusions.
Acta neuropathologica
Huang Y,Song YJ,Murphy K,Holton JL,Lashley T,Revesz T,Gai WP,Halliday GM
Mon Dec 01 00:00:00 UTC 2008
LRRK2 and parkin immunoreactivity in multiple system atrophy inclusions.
Acta neuropathologica
Huang Y,Song YJ,Murphy K,Holton JL,Lashley T,Revesz T,Gai WP,Halliday GM
Mon Dec 01 00:00:00 UTC 2008
Immunohistochemical identification of messenger RNA-related proteins in basophilic inclusions of adult-onset atypical motor neuron disease.
Acta neuropathologica
Fujita K,Ito H,Nakano S,Kinoshita Y,Wate R,Kusaka H
Wed Oct 01 00:00:00 UTC 2008
Immunohistochemical identification of messenger RNA-related proteins in basophilic inclusions of adult-onset atypical motor neuron disease.
Acta neuropathologica
Fujita K,Ito H,Nakano S,Kinoshita Y,Wate R,Kusaka H
Wed Oct 01 00:00:00 UTC 2008
Frontotemporal lobar degeneration with ubiquitin-positive, but TDP-43-negative inclusions.
Acta neuropathologica
Josephs KA,Lin WL,Ahmed Z,Stroh DA,Graff-Radford NR,Dickson DW
Fri Aug 01 00:00:00 UTC 2008
Frontotemporal lobar degeneration with ubiquitin-positive, but TDP-43-negative inclusions.
Acta neuropathologica
Josephs KA,Lin WL,Ahmed Z,Stroh DA,Graff-Radford NR,Dickson DW
Fri Aug 01 00:00:00 UTC 2008
TDP-43-negative FTLD-U is a significant new clinico-pathological subtype of FTLD.
Acta neuropathologica
Roeber S,Mackenzie IR,Kretzschmar HA,Neumann M
Fri Aug 01 00:00:00 UTC 2008
TDP-43-negative FTLD-U is a significant new clinico-pathological subtype of FTLD.
Acta neuropathologica
Roeber S,Mackenzie IR,Kretzschmar HA,Neumann M
Fri Aug 01 00:00:00 UTC 2008
Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam.
Acta neuropathologica
Geser F,Winton MJ,Kwong LK,Xu Y,Xie SX,Igaz LM,Garruto RM,Perl DP,Galasko D,Lee VM,Trojanowski JQ
Tue Jan 01 00:00:00 UTC 2008
Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam.
Acta neuropathologica
Geser F,Winton MJ,Kwong LK,Xu Y,Xie SX,Igaz LM,Garruto RM,Perl DP,Galasko D,Lee VM,Trojanowski JQ
Tue Jan 01 00:00:00 UTC 2008
Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam.
Acta neuropathologica
Geser F,Winton MJ,Kwong LK,Xu Y,Xie SX,Igaz LM,Garruto RM,Perl DP,Galasko D,Lee VM,Trojanowski JQ
Tue Jan 01 00:00:00 UTC 2008
Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam.
Acta neuropathologica
Geser F,Winton MJ,Kwong LK,Xu Y,Xie SX,Igaz LM,Garruto RM,Perl DP,Galasko D,Lee VM,Trojanowski JQ
Tue Jan 01 00:00:00 UTC 2008
Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam.
Acta neuropathologica
Geser F,Winton MJ,Kwong LK,Xu Y,Xie SX,Igaz LM,Garruto RM,Perl DP,Galasko D,Lee VM,Trojanowski JQ
Tue Jan 01 00:00:00 UTC 2008
Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam.
Acta neuropathologica
Geser F,Winton MJ,Kwong LK,Xu Y,Xie SX,Igaz LM,Garruto RM,Perl DP,Galasko D,Lee VM,Trojanowski JQ
Tue Jan 01 00:00:00 UTC 2008
Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam.
Acta neuropathologica
Geser F,Winton MJ,Kwong LK,Xu Y,Xie SX,Igaz LM,Garruto RM,Perl DP,Galasko D,Lee VM,Trojanowski JQ
Tue Jan 01 00:00:00 UTC 2008
TDP-43 inclusions do not protect motor neurons from sporadic ALS.
Acta neuropathologica
Pamphlett R,Kum Jew S
Fri Aug 01 00:00:00 UTC 2008
TDP-43 inclusions do not protect motor neurons from sporadic ALS.
Acta neuropathologica
Pamphlett R,Kum Jew S
Fri Aug 01 00:00:00 UTC 2008
Severe subcortical TDP-43 pathology in sporadic frontotemporal lobar degeneration with motor neuron disease.
Acta neuropathologica
Brandmeir NJ,Geser F,Kwong LK,Zimmerman E,Qian J,Lee VM,Trojanowski JQ
Tue Jan 01 00:00:00 UTC 2008
Severe subcortical TDP-43 pathology in sporadic frontotemporal lobar degeneration with motor neuron disease.
Acta neuropathologica
Brandmeir NJ,Geser F,Kwong LK,Zimmerman E,Qian J,Lee VM,Trojanowski JQ
Tue Jan 01 00:00:00 UTC 2008
Severe subcortical TDP-43 pathology in sporadic frontotemporal lobar degeneration with motor neuron disease.
Acta neuropathologica
Brandmeir NJ,Geser F,Kwong LK,Zimmerman E,Qian J,Lee VM,Trojanowski JQ
Tue Jan 01 00:00:00 UTC 2008
Sporadic amyotrophic lateral sclerosis: two pathological patterns shown by analysis of distribution of TDP-43-immunoreactive neuronal and glial cytoplasmic inclusions.
Acta neuropathologica
Nishihira Y,Tan CF,Onodera O,Toyoshima Y,Yamada M,Morita T,Nishizawa M,Kakita A,Takahashi H
Fri Aug 01 00:00:00 UTC 2008
Sporadic amyotrophic lateral sclerosis: two pathological patterns shown by analysis of distribution of TDP-43-immunoreactive neuronal and glial cytoplasmic inclusions.
Acta neuropathologica
Nishihira Y,Tan CF,Onodera O,Toyoshima Y,Yamada M,Morita T,Nishizawa M,Kakita A,Takahashi H
Fri Aug 01 00:00:00 UTC 2008
Sporadic amyotrophic lateral sclerosis: two pathological patterns shown by analysis of distribution of TDP-43-immunoreactive neuronal and glial cytoplasmic inclusions.
Acta neuropathologica
Nishihira Y,Tan CF,Onodera O,Toyoshima Y,Yamada M,Morita T,Nishizawa M,Kakita A,Takahashi H
Fri Aug 01 00:00:00 UTC 2008
Clinical, neuropathological and genotypic variability in SNCA A53T familial Parkinson's disease. Variability in familial Parkinson's disease.
Acta neuropathologica
Markopoulou K,Dickson DW,McComb RD,Wszolek ZK,Katechalidou L,Avery L,Stansbury MS,Chase BA
Tue Jul 01 00:00:00 UTC 2008
Clinical, neuropathological and genotypic variability in SNCA A53T familial Parkinson's disease. Variability in familial Parkinson's disease.
Acta neuropathologica
Markopoulou K,Dickson DW,McComb RD,Wszolek ZK,Katechalidou L,Avery L,Stansbury MS,Chase BA
Tue Jul 01 00:00:00 UTC 2008
Maturation process of TDP-43-positive neuronal cytoplasmic inclusions in amyotrophic lateral sclerosis with and without dementia.
Acta neuropathologica
Mori F,Tanji K,Zhang HX,Nishihira Y,Tan CF,Takahashi H,Wakabayashi K
Fri Aug 01 00:00:00 UTC 2008
Maturation process of TDP-43-positive neuronal cytoplasmic inclusions in amyotrophic lateral sclerosis with and without dementia.
Acta neuropathologica
Mori F,Tanji K,Zhang HX,Nishihira Y,Tan CF,Takahashi H,Wakabayashi K
Fri Aug 01 00:00:00 UTC 2008
TDP-43-immunoreactive neuronal and glial inclusions in the neostriatum in amyotrophic lateral sclerosis with and without dementia.
Acta neuropathologica
Zhang H,Tan CF,Mori F,Tanji K,Kakita A,Takahashi H,Wakabayashi K
Tue Jan 01 00:00:00 UTC 2008
TDP-43-immunoreactive neuronal and glial inclusions in the neostriatum in amyotrophic lateral sclerosis with and without dementia.
Acta neuropathologica
Zhang H,Tan CF,Mori F,Tanji K,Kakita A,Takahashi H,Wakabayashi K
Tue Jan 01 00:00:00 UTC 2008
TDP-43-immunoreactive neuronal and glial inclusions in the neostriatum in amyotrophic lateral sclerosis with and without dementia.
Acta neuropathologica
Zhang H,Tan CF,Mori F,Tanji K,Kakita A,Takahashi H,Wakabayashi K
Tue Jan 01 00:00:00 UTC 2008
Enduring involvement of tau, beta-amyloid, alpha-synuclein, ubiquitin and TDP-43 pathology in the amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam (ALS/PDC).
Acta neuropathologica
Miklossy J,Steele JC,Yu S,McCall S,Sandberg G,McGeer EG,McGeer PL
Mon Dec 01 00:00:00 UTC 2008
Enduring involvement of tau, beta-amyloid, alpha-synuclein, ubiquitin and TDP-43 pathology in the amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam (ALS/PDC).
Acta neuropathologica
Miklossy J,Steele JC,Yu S,McCall S,Sandberg G,McGeer EG,McGeer PL
Mon Dec 01 00:00:00 UTC 2008
Basophilic inclusion body disease and neuronal intermediate filament inclusion disease: a comparative clinicopathological study.
Acta neuropathologica
Yokota O,Tsuchiya K,Terada S,Ishizu H,Uchikado H,Ikeda M,Oyanagi K,Nakano I,Murayama S,Kuroda S,Akiyama H
Thu May 01 00:00:00 UTC 2008
Basophilic inclusion body disease and neuronal intermediate filament inclusion disease: a comparative clinicopathological study.
Acta neuropathologica
Yokota O,Tsuchiya K,Terada S,Ishizu H,Uchikado H,Ikeda M,Oyanagi K,Nakano I,Murayama S,Kuroda S,Akiyama H
Thu May 01 00:00:00 UTC 2008
Phosphorylated Smad2/3 immunoreactivity in sporadic and familial amyotrophic lateral sclerosis and its mouse model.
Acta neuropathologica
Nakamura M,Ito H,Wate R,Nakano S,Hirano A,Kusaka H
Sat Mar 01 00:00:00 UTC 2008
Phosphorylated Smad2/3 immunoreactivity in sporadic and familial amyotrophic lateral sclerosis and its mouse model.
Acta neuropathologica
Nakamura M,Ito H,Wate R,Nakano S,Hirano A,Kusaka H
Sat Mar 01 00:00:00 UTC 2008
Frequency and clinical characteristics of progranulin mutation carriers in the Manchester frontotemporal lobar degeneration cohort: comparison with patients with MAPT and no known mutations.
Brain : a journal of neurology
Pickering-Brown SM,Rollinson S,Du Plessis D,Morrison KE,Varma A,Richardson AM,Neary D,Snowden JS,Mann DM
Sat Mar 01 00:00:00 UTC 2008
Frequency and clinical characteristics of progranulin mutation carriers in the Manchester frontotemporal lobar degeneration cohort: comparison with patients with MAPT and no known mutations.
Brain : a journal of neurology
Pickering-Brown SM,Rollinson S,Du Plessis D,Morrison KE,Varma A,Richardson AM,Neary D,Snowden JS,Mann DM
Sat Mar 01 00:00:00 UTC 2008
Atypical frontotemporal lobar degeneration with ubiquitin-positive, TDP-43-negative neuronal inclusions.
Brain : a journal of neurology
Mackenzie IR,Foti D,Woulfe J,Hurwitz TA
Thu May 01 00:00:00 UTC 2008
Atypical frontotemporal lobar degeneration with ubiquitin-positive, TDP-43-negative neuronal inclusions.
Brain : a journal of neurology
Mackenzie IR,Foti D,Woulfe J,Hurwitz TA
Thu May 01 00:00:00 UTC 2008
Atypical frontotemporal lobar degeneration with ubiquitin-positive, TDP-43-negative neuronal inclusions.
Brain : a journal of neurology
Mackenzie IR,Foti D,Woulfe J,Hurwitz TA
Thu May 01 00:00:00 UTC 2008
TDP-43 accumulation in inclusion body myopathy muscle suggests a common pathogenic mechanism with frontotemporal dementia.
Journal of neurology, neurosurgery, and psychiatry
Weihl CC,Temiz P,Miller SE,Watts G,Smith C,Forman M,Hanson PI,Kimonis V,Pestronk A
Wed Oct 01 00:00:00 UTC 2008
TDP-43 accumulation in inclusion body myopathy muscle suggests a common pathogenic mechanism with frontotemporal dementia.
Journal of neurology, neurosurgery, and psychiatry
Weihl CC,Temiz P,Miller SE,Watts G,Smith C,Forman M,Hanson PI,Kimonis V,Pestronk A
Wed Oct 01 00:00:00 UTC 2008
TDP-43 accumulation in inclusion body myopathy muscle suggests a common pathogenic mechanism with frontotemporal dementia.
Journal of neurology, neurosurgery, and psychiatry
Weihl CC,Temiz P,Miller SE,Watts G,Smith C,Forman M,Hanson PI,Kimonis V,Pestronk A
Wed Oct 01 00:00:00 UTC 2008
TDP-43 accumulation in inclusion body myopathy muscle suggests a common pathogenic mechanism with frontotemporal dementia.
Journal of neurology, neurosurgery, and psychiatry
Weihl CC,Temiz P,Miller SE,Watts G,Smith C,Forman M,Hanson PI,Kimonis V,Pestronk A
Wed Oct 01 00:00:00 UTC 2008
Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia.
Proceedings of the National Academy of Sciences of the United States of America
Kim HJ,Fan X,Gabbi C,Yakimchuk K,Parini P,Warner M,Gustafsson JA
Tue Feb 12 00:00:00 UTC 2008
Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia.
Proceedings of the National Academy of Sciences of the United States of America
Kim HJ,Fan X,Gabbi C,Yakimchuk K,Parini P,Warner M,Gustafsson JA
Tue Feb 12 00:00:00 UTC 2008
Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia.
Proceedings of the National Academy of Sciences of the United States of America
Kim HJ,Fan X,Gabbi C,Yakimchuk K,Parini P,Warner M,Gustafsson JA
Tue Feb 12 00:00:00 UTC 2008
Abnormal TDP-43 immunoreactivity in AD modifies clinicopathologic and radiologic phenotype.
Neurology
Josephs KA,Whitwell JL,Knopman DS,Hu WT,Stroh DA,Baker M,Rademakers R,Boeve BF,Parisi JE,Smith GE,Ivnik RJ,Petersen RC,Jack CR,Dickson DW
Tue May 06 00:00:00 UTC 2008
Abnormal TDP-43 immunoreactivity in AD modifies clinicopathologic and radiologic phenotype.
Neurology
Josephs KA,Whitwell JL,Knopman DS,Hu WT,Stroh DA,Baker M,Rademakers R,Boeve BF,Parisi JE,Smith GE,Ivnik RJ,Petersen RC,Jack CR,Dickson DW
Tue May 06 00:00:00 UTC 2008
TDP-43 mutation in familial amyotrophic lateral sclerosis.
Annals of neurology
Yokoseki A,Shiga A,Tan CF,Tagawa A,Kaneko H,Koyama A,Eguchi H,Tsujino A,Ikeuchi T,Kakita A,Okamoto K,Nishizawa M,Takahashi H,Onodera O
Tue Apr 01 00:00:00 UTC 2008
TDP-43 mutation in familial amyotrophic lateral sclerosis.
Annals of neurology
Yokoseki A,Shiga A,Tan CF,Tagawa A,Kaneko H,Koyama A,Eguchi H,Tsujino A,Ikeuchi T,Kakita A,Okamoto K,Nishizawa M,Takahashi H,Onodera O
Tue Apr 01 00:00:00 UTC 2008
TDP-43 mutation in familial amyotrophic lateral sclerosis.
Annals of neurology
Yokoseki A,Shiga A,Tan CF,Tagawa A,Kaneko H,Koyama A,Eguchi H,Tsujino A,Ikeuchi T,Kakita A,Okamoto K,Nishizawa M,Takahashi H,Onodera O
Tue Apr 01 00:00:00 UTC 2008
TDP-43 mutation in familial amyotrophic lateral sclerosis.
Annals of neurology
Yokoseki A,Shiga A,Tan CF,Tagawa A,Kaneko H,Koyama A,Eguchi H,Tsujino A,Ikeuchi T,Kakita A,Okamoto K,Nishizawa M,Takahashi H,Onodera O
Tue Apr 01 00:00:00 UTC 2008
Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Annals of neurology
Hasegawa M,Arai T,Nonaka T,Kametani F,Yoshida M,Hashizume Y,Beach TG,Buratti E,Baralle F,Morita M,Nakano I,Oda T,Tsuchiya K,Akiyama H
Tue Jul 01 00:00:00 UTC 2008
Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Annals of neurology
Hasegawa M,Arai T,Nonaka T,Kametani F,Yoshida M,Hashizume Y,Beach TG,Buratti E,Baralle F,Morita M,Nakano I,Oda T,Tsuchiya K,Akiyama H
Tue Jul 01 00:00:00 UTC 2008
Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Annals of neurology
Hasegawa M,Arai T,Nonaka T,Kametani F,Yoshida M,Hashizume Y,Beach TG,Buratti E,Baralle F,Morita M,Nakano I,Oda T,Tsuchiya K,Akiyama H
Tue Jul 01 00:00:00 UTC 2008
Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Annals of neurology
Hasegawa M,Arai T,Nonaka T,Kametani F,Yoshida M,Hashizume Y,Beach TG,Buratti E,Baralle F,Morita M,Nakano I,Oda T,Tsuchiya K,Akiyama H
Tue Jul 01 00:00:00 UTC 2008
Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia.
Annals of neurology
Mesulam M,Wicklund A,Johnson N,Rogalski E,Léger GC,Rademaker A,Weintraub S,Bigio EH
Sun Jun 01 00:00:00 UTC 2008
Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia.
Annals of neurology
Mesulam M,Wicklund A,Johnson N,Rogalski E,Léger GC,Rademaker A,Weintraub S,Bigio EH
Sun Jun 01 00:00:00 UTC 2008
Progranulin gene mutation with an unusual clinical and neuropathologic presentation.
Movement disorders : official journal of the Movement Disorder Society
Wider C,Uitti RJ,Wszolek ZK,Fang JY,Josephs KA,Baker MC,Rademakers R,Hutton ML,Dickson DW
Sun Jun 15 00:00:00 UTC 2008
Progranulin gene mutation with an unusual clinical and neuropathologic presentation.
Movement disorders : official journal of the Movement Disorder Society
Wider C,Uitti RJ,Wszolek ZK,Fang JY,Josephs KA,Baker MC,Rademakers R,Hutton ML,Dickson DW
Sun Jun 15 00:00:00 UTC 2008
Lack of TAR-DNA binding protein-43 (TDP-43) pathology in human prion diseases.
Neuropathology and applied neurobiology
Isaacs AM,Powell C,Webb TE,Linehan JM,Collinge J,Brandner S
Fri Aug 01 00:00:00 UTC 2008
Lack of TAR-DNA binding protein-43 (TDP-43) pathology in human prion diseases.
Neuropathology and applied neurobiology
Isaacs AM,Powell C,Webb TE,Linehan JM,Collinge J,Brandner S
Fri Aug 01 00:00:00 UTC 2008
Lack of TAR-DNA binding protein-43 (TDP-43) pathology in human prion diseases.
Neuropathology and applied neurobiology
Isaacs AM,Powell C,Webb TE,Linehan JM,Collinge J,Brandner S
Fri Aug 01 00:00:00 UTC 2008
Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
The American journal of pathology
Igaz LM,Kwong LK,Xu Y,Truax AC,Uryu K,Neumann M,Clark CM,Elman LB,Miller BL,Grossman M,McCluskey LF,Trojanowski JQ,Lee VM
Tue Jul 01 00:00:00 UTC 2008
Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
The American journal of pathology
Igaz LM,Kwong LK,Xu Y,Truax AC,Uryu K,Neumann M,Clark CM,Elman LB,Miller BL,Grossman M,McCluskey LF,Trojanowski JQ,Lee VM
Tue Jul 01 00:00:00 UTC 2008
Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
The American journal of pathology
Igaz LM,Kwong LK,Xu Y,Truax AC,Uryu K,Neumann M,Clark CM,Elman LB,Miller BL,Grossman M,McCluskey LF,Trojanowski JQ,Lee VM
Tue Jul 01 00:00:00 UTC 2008
Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
The American journal of pathology
Igaz LM,Kwong LK,Xu Y,Truax AC,Uryu K,Neumann M,Clark CM,Elman LB,Miller BL,Grossman M,McCluskey LF,Trojanowski JQ,Lee VM
Tue Jul 01 00:00:00 UTC 2008
Structural determinants of the cellular localization and shuttling of TDP-43.
Journal of cell science
Ayala YM,Zago P,D'Ambrogio A,Xu YF,Petrucelli L,Buratti E,Baralle FE
Sat Nov 15 00:00:00 UTC 2008
Structural determinants of the cellular localization and shuttling of TDP-43.
Journal of cell science
Ayala YM,Zago P,D'Ambrogio A,Xu YF,Petrucelli L,Buratti E,Baralle FE
Sat Nov 15 00:00:00 UTC 2008
Structural determinants of the cellular localization and shuttling of TDP-43.
Journal of cell science
Ayala YM,Zago P,D'Ambrogio A,Xu YF,Petrucelli L,Buratti E,Baralle FE
Sat Nov 15 00:00:00 UTC 2008
Structural determinants of the cellular localization and shuttling of TDP-43.
Journal of cell science
Ayala YM,Zago P,D'Ambrogio A,Xu YF,Petrucelli L,Buratti E,Baralle FE
Sat Nov 15 00:00:00 UTC 2008
Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia.
Human molecular genetics
Rademakers R,Eriksen JL,Baker M,Robinson T,Ahmed Z,Lincoln SJ,Finch N,Rutherford NJ,Crook RJ,Josephs KA,Boeve BF,Knopman DS,Petersen RC,Parisi JE,Caselli RJ,Wszolek ZK,Uitti RJ,Feldman H,Hutton ML,Mackenzie IR,Graff-Radford NR,Dickson DW
Mon Dec 01 00:00:00 UTC 2008
Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia.
Human molecular genetics
Rademakers R,Eriksen JL,Baker M,Robinson T,Ahmed Z,Lincoln SJ,Finch N,Rutherford NJ,Crook RJ,Josephs KA,Boeve BF,Knopman DS,Petersen RC,Parisi JE,Caselli RJ,Wszolek ZK,Uitti RJ,Feldman H,Hutton ML,Mackenzie IR,Graff-Radford NR,Dickson DW
Mon Dec 01 00:00:00 UTC 2008
Anterior horn cells with abnormal TDP-43 immunoreactivities show fragmentation of the Golgi apparatus in ALS.
Journal of the neurological sciences
Fujita Y,Mizuno Y,Takatama M,Okamoto K
Sun Jun 15 00:00:00 UTC 2008
Anterior horn cells with abnormal TDP-43 immunoreactivities show fragmentation of the Golgi apparatus in ALS.
Journal of the neurological sciences
Fujita Y,Mizuno Y,Takatama M,Okamoto K
Sun Jun 15 00:00:00 UTC 2008
Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS.
FEBS letters
Inukai Y,Nonaka T,Arai T,Yoshida M,Hashizume Y,Beach TG,Buratti E,Baralle FE,Akiyama H,Hisanaga S,Hasegawa M
Wed Aug 20 00:00:00 UTC 2008
Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS.
FEBS letters
Inukai Y,Nonaka T,Arai T,Yoshida M,Hashizume Y,Beach TG,Buratti E,Baralle FE,Akiyama H,Hisanaga S,Hasegawa M
Wed Aug 20 00:00:00 UTC 2008
Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS.
FEBS letters
Inukai Y,Nonaka T,Arai T,Yoshida M,Hashizume Y,Beach TG,Buratti E,Baralle FE,Akiyama H,Hisanaga S,Hasegawa M
Wed Aug 20 00:00:00 UTC 2008
Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS.
FEBS letters
Inukai Y,Nonaka T,Arai T,Yoshida M,Hashizume Y,Beach TG,Buratti E,Baralle FE,Akiyama H,Hisanaga S,Hasegawa M
Wed Aug 20 00:00:00 UTC 2008
A90V TDP-43 variant results in the aberrant localization of TDP-43 in vitro.
FEBS letters
Winton MJ,Van Deerlin VM,Kwong LK,Yuan W,Wood EM,Yu CE,Schellenberg GD,Rademakers R,Caselli R,Karydas A,Trojanowski JQ,Miller BL,Lee VM
Wed Jun 25 00:00:00 UTC 2008
A90V TDP-43 variant results in the aberrant localization of TDP-43 in vitro.
FEBS letters
Winton MJ,Van Deerlin VM,Kwong LK,Yuan W,Wood EM,Yu CE,Schellenberg GD,Rademakers R,Caselli R,Karydas A,Trojanowski JQ,Miller BL,Lee VM
Wed Jun 25 00:00:00 UTC 2008
A90V TDP-43 variant results in the aberrant localization of TDP-43 in vitro.
FEBS letters
Winton MJ,Van Deerlin VM,Kwong LK,Yuan W,Wood EM,Yu CE,Schellenberg GD,Rademakers R,Caselli R,Karydas A,Trojanowski JQ,Miller BL,Lee VM
Wed Jun 25 00:00:00 UTC 2008
A90V TDP-43 variant results in the aberrant localization of TDP-43 in vitro.
FEBS letters
Winton MJ,Van Deerlin VM,Kwong LK,Yuan W,Wood EM,Yu CE,Schellenberg GD,Rademakers R,Caselli R,Karydas A,Trojanowski JQ,Miller BL,Lee VM
Wed Jun 25 00:00:00 UTC 2008
Pilot study of granulocyte colony stimulating factor (G-CSF)-mobilized peripheral blood stem cells in amyotrophic lateral sclerosis (ALS).
Muscle & nerve
Cashman N,Tan LY,Krieger C,Mädler B,Mackay A,Mackenzie I,Benny B,Nantel S,Fabros M,Shinobu L,Yousefi M,Eisen A
Thu May 01 00:00:00 UTC 2008
Pilot study of granulocyte colony stimulating factor (G-CSF)-mobilized peripheral blood stem cells in amyotrophic lateral sclerosis (ALS).
Muscle & nerve
Cashman N,Tan LY,Krieger C,Mädler B,Mackay A,Mackenzie I,Benny B,Nantel S,Fabros M,Shinobu L,Yousefi M,Eisen A
Thu May 01 00:00:00 UTC 2008
Fine structural analysis of the neuronal inclusions of frontotemporal lobar degeneration with TDP-43 proteinopathy.
Journal of neural transmission (Vienna, Austria : 1996)
Thorpe JR,Tang H,Atherton J,Cairns NJ
Mon Dec 01 00:00:00 UTC 2008
Fine structural analysis of the neuronal inclusions of frontotemporal lobar degeneration with TDP-43 proteinopathy.
Journal of neural transmission (Vienna, Austria : 1996)
Thorpe JR,Tang H,Atherton J,Cairns NJ
Mon Dec 01 00:00:00 UTC 2008
Caspase-cleaved TAR DNA-binding protein-43 is a major pathological finding in Alzheimer's disease.
Brain research
Rohn TT
Thu Sep 04 00:00:00 UTC 2008
Caspase-cleaved TAR DNA-binding protein-43 is a major pathological finding in Alzheimer's disease.
Brain research
Rohn TT
Thu Sep 04 00:00:00 UTC 2008
Caspase-cleaved TAR DNA-binding protein-43 is a major pathological finding in Alzheimer's disease.
Brain research
Rohn TT
Thu Sep 04 00:00:00 UTC 2008
Caspase-cleaved TAR DNA-binding protein-43 is a major pathological finding in Alzheimer's disease.
Brain research
Rohn TT
Thu Sep 04 00:00:00 UTC 2008
Epitope mapping of 2E2-D3, a monoclonal antibody directed against human TDP-43.
Neuroscience letters
Zhang HX,Tanji K,Mori F,Wakabayashi K
Fri Mar 28 00:00:00 UTC 2008
Epitope mapping of 2E2-D3, a monoclonal antibody directed against human TDP-43.
Neuroscience letters
Zhang HX,Tanji K,Mori F,Wakabayashi K
Fri Mar 28 00:00:00 UTC 2008
Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions visualized with ubiquitin-binding protein p62 immunohistochemistry.
Journal of neuropathology and experimental neurology
Pikkarainen M,Hartikainen P,Alafuzoff I
Tue Apr 01 00:00:00 UTC 2008
Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions visualized with ubiquitin-binding protein p62 immunohistochemistry.
Journal of neuropathology and experimental neurology
Pikkarainen M,Hartikainen P,Alafuzoff I
Tue Apr 01 00:00:00 UTC 2008
TAR-DNA binding protein 43 in Pick disease.
Journal of neuropathology and experimental neurology
Freeman SH,Spires-Jones T,Hyman BT,Growdon JH,Frosch MP
Tue Jan 01 00:00:00 UTC 2008
TAR-DNA binding protein 43 in Pick disease.
Journal of neuropathology and experimental neurology
Freeman SH,Spires-Jones T,Hyman BT,Growdon JH,Frosch MP
Tue Jan 01 00:00:00 UTC 2008
TAR DNA-binding protein 43 immunohistochemistry reveals extensive neuritic pathology in FTLD-U: a midwest-southwest consortium for FTLD study.
Journal of neuropathology and experimental neurology
Hatanpaa KJ,Bigio EH,Cairns NJ,Womack KB,Weintraub S,Morris JC,Foong C,Xiao G,Hladik C,Mantanona TY,White CL
Tue Apr 01 00:00:00 UTC 2008
TAR DNA-binding protein 43 immunohistochemistry reveals extensive neuritic pathology in FTLD-U: a midwest-southwest consortium for FTLD study.
Journal of neuropathology and experimental neurology
Hatanpaa KJ,Bigio EH,Cairns NJ,Womack KB,Weintraub S,Morris JC,Foong C,Xiao G,Hladik C,Mantanona TY,White CL
Tue Apr 01 00:00:00 UTC 2008
Colocalization of transactivation-responsive DNA-binding protein 43 and huntingtin in inclusions of Huntington disease.
Journal of neuropathology and experimental neurology
Schwab C,Arai T,Hasegawa M,Yu S,McGeer PL
Mon Dec 01 00:00:00 UTC 2008
Colocalization of transactivation-responsive DNA-binding protein 43 and huntingtin in inclusions of Huntington disease.
Journal of neuropathology and experimental neurology
Schwab C,Arai T,Hasegawa M,Yu S,McGeer PL
Mon Dec 01 00:00:00 UTC 2008
Concomitant TAR-DNA-binding protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathies.
Journal of neuropathology and experimental neurology
Uryu K,Nakashima-Yasuda H,Forman MS,Kwong LK,Clark CM,Grossman M,Miller BL,Kretzschmar HA,Lee VM,Trojanowski JQ,Neumann M
Sun Jun 01 00:00:00 UTC 2008
Concomitant TAR-DNA-binding protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathies.
Journal of neuropathology and experimental neurology
Uryu K,Nakashima-Yasuda H,Forman MS,Kwong LK,Clark CM,Grossman M,Miller BL,Kretzschmar HA,Lee VM,Trojanowski JQ,Neumann M
Sun Jun 01 00:00:00 UTC 2008
White matter tauopathy with globular glial inclusions: a distinct sporadic frontotemporal lobar degeneration.
Journal of neuropathology and experimental neurology
Kovacs GG,Majtenyi K,Spina S,Murrell JR,Gelpi E,Hoftberger R,Fraser G,Crowther RA,Goedert M,Budka H,Ghetti B
Wed Oct 01 00:00:00 UTC 2008
White matter tauopathy with globular glial inclusions: a distinct sporadic frontotemporal lobar degeneration.
Journal of neuropathology and experimental neurology
Kovacs GG,Majtenyi K,Spina S,Murrell JR,Gelpi E,Hoftberger R,Fraser G,Crowther RA,Goedert M,Budka H,Ghetti B
Wed Oct 01 00:00:00 UTC 2008
Update on recent molecular and genetic advances in frontotemporal lobar degeneration.
Journal of neuropathology and experimental neurology
Bigio EH
Tue Jul 01 00:00:00 UTC 2008
Update on recent molecular and genetic advances in frontotemporal lobar degeneration.
Journal of neuropathology and experimental neurology
Bigio EH
Tue Jul 01 00:00:00 UTC 2008
Early onset familial Alzheimer Disease with spastic paraparesis, dysarthria, and seizures and N135S mutation in PSEN1.
Alzheimer disease and associated disorders
Rudzinski LA,Fletcher RM,Dickson DW,Crook R,Hutton ML,Adamson J,Graff-Radford NR
Tue Nov 18 00:00:00 UTC 2008
Early onset familial Alzheimer Disease with spastic paraparesis, dysarthria, and seizures and N135S mutation in PSEN1.
Alzheimer disease and associated disorders
Rudzinski LA,Fletcher RM,Dickson DW,Crook R,Hutton ML,Adamson J,Graff-Radford NR
Tue Nov 18 00:00:00 UTC 2008
Frontotemporal dementia mimicking dementia with Lewy bodies.
Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology
Claassen DO,Parisi JE,Giannini C,Boeve BF,Dickson DW,Josephs KA
Mon Sep 01 00:00:00 UTC 2008
Frontotemporal dementia mimicking dementia with Lewy bodies.
Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology
Claassen DO,Parisi JE,Giannini C,Boeve BF,Dickson DW,Josephs KA
Mon Sep 01 00:00:00 UTC 2008
Pedigree with frontotemporal lobar degeneration--motor neuron disease and Tar DNA binding protein-43 positive neuropathology: genetic linkage to chromosome 9.
BMC neurology
Luty AA,Kwok JB,Thompson EM,Blumbergs P,Brooks WS,Loy CT,Dobson-Stone C,Panegyres PK,Hecker J,Nicholson GA,Halliday GM,Schofield PR
Fri Aug 29 00:00:00 UTC 2008
Pedigree with frontotemporal lobar degeneration--motor neuron disease and Tar DNA binding protein-43 positive neuropathology: genetic linkage to chromosome 9.
BMC neurology
Luty AA,Kwok JB,Thompson EM,Blumbergs P,Brooks WS,Loy CT,Dobson-Stone C,Panegyres PK,Hecker J,Nicholson GA,Halliday GM,Schofield PR
Fri Aug 29 00:00:00 UTC 2008
Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation.
The Journal of biological chemistry
Winton MJ,Igaz LM,Wong MM,Kwong LK,Trojanowski JQ,Lee VM
Fri May 09 00:00:00 UTC 2008
Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation.
The Journal of biological chemistry
Winton MJ,Igaz LM,Wong MM,Kwong LK,Trojanowski JQ,Lee VM
Fri May 09 00:00:00 UTC 2008
Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation.
The Journal of biological chemistry
Winton MJ,Igaz LM,Wong MM,Kwong LK,Trojanowski JQ,Lee VM
Fri May 09 00:00:00 UTC 2008
Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation.
The Journal of biological chemistry
Winton MJ,Igaz LM,Wong MM,Kwong LK,Trojanowski JQ,Lee VM
Fri May 09 00:00:00 UTC 2008
Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation.
The Journal of biological chemistry
Winton MJ,Igaz LM,Wong MM,Kwong LK,Trojanowski JQ,Lee VM
Fri May 09 00:00:00 UTC 2008
Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation.
The Journal of biological chemistry
Winton MJ,Igaz LM,Wong MM,Kwong LK,Trojanowski JQ,Lee VM
Fri May 09 00:00:00 UTC 2008
Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation.
The Journal of biological chemistry
Winton MJ,Igaz LM,Wong MM,Kwong LK,Trojanowski JQ,Lee VM
Fri May 09 00:00:00 UTC 2008
Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis.
Archives of neurology
Geser F,Brandmeir NJ,Kwong LK,Martinez-Lage M,Elman L,McCluskey L,Xie SX,Lee VM,Trojanowski JQ
Thu May 01 00:00:00 UTC 2008
Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis.
Archives of neurology
Geser F,Brandmeir NJ,Kwong LK,Martinez-Lage M,Elman L,McCluskey L,Xie SX,Lee VM,Trojanowski JQ
Thu May 01 00:00:00 UTC 2008
Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion.
The Journal of biological chemistry
Shankaran SS,Capell A,Hruscha AT,Fellerer K,Neumann M,Schmid B,Haass C
Fri Jan 18 00:00:00 UTC 2008
Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion.
The Journal of biological chemistry
Shankaran SS,Capell A,Hruscha AT,Fellerer K,Neumann M,Schmid B,Haass C
Fri Jan 18 00:00:00 UTC 2008
Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion.
The Journal of biological chemistry
Shankaran SS,Capell A,Hruscha AT,Fellerer K,Neumann M,Schmid B,Haass C
Fri Jan 18 00:00:00 UTC 2008
Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion.
The Journal of biological chemistry
Shankaran SS,Capell A,Hruscha AT,Fellerer K,Neumann M,Schmid B,Haass C
Fri Jan 18 00:00:00 UTC 2008
Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion.
The Journal of biological chemistry
Shankaran SS,Capell A,Hruscha AT,Fellerer K,Neumann M,Schmid B,Haass C
Fri Jan 18 00:00:00 UTC 2008
Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion.
The Journal of biological chemistry
Shankaran SS,Capell A,Hruscha AT,Fellerer K,Neumann M,Schmid B,Haass C
Fri Jan 18 00:00:00 UTC 2008
Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion.
The Journal of biological chemistry
Shankaran SS,Capell A,Hruscha AT,Fellerer K,Neumann M,Schmid B,Haass C
Fri Jan 18 00:00:00 UTC 2008
TDP-43 in cerebrospinal fluid of patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Archives of neurology
Steinacker P,Hendrich C,Sperfeld AD,Jesse S,von Arnim CA,Lehnert S,Pabst A,Uttner I,Tumani H,Lee VM,Trojanowski JQ,Kretzschmar HA,Ludolph A,Neumann M,Otto M
Sat Nov 01 00:00:00 UTC 2008
TDP-43 in cerebrospinal fluid of patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Archives of neurology
Steinacker P,Hendrich C,Sperfeld AD,Jesse S,von Arnim CA,Lehnert S,Pabst A,Uttner I,Tumani H,Lee VM,Trojanowski JQ,Kretzschmar HA,Ludolph A,Neumann M,Otto M
Sat Nov 01 00:00:00 UTC 2008
TDP-43 expression in mouse models of amyotrophic lateral sclerosis and spinal muscular atrophy.
BMC neuroscience
Turner BJ,Bäumer D,Parkinson NJ,Scaber J,Ansorge O,Talbot K
Tue Oct 28 00:00:00 UTC 2008
TDP-43 expression in mouse models of amyotrophic lateral sclerosis and spinal muscular atrophy.
BMC neuroscience
Turner BJ,Bäumer D,Parkinson NJ,Scaber J,Ansorge O,Talbot K
Tue Oct 28 00:00:00 UTC 2008
TDP-43 expression in mouse models of amyotrophic lateral sclerosis and spinal muscular atrophy.
BMC neuroscience
Turner BJ,Bäumer D,Parkinson NJ,Scaber J,Ansorge O,Talbot K
Tue Oct 28 00:00:00 UTC 2008
TDP-43 expression in mouse models of amyotrophic lateral sclerosis and spinal muscular atrophy.
BMC neuroscience
Turner BJ,Bäumer D,Parkinson NJ,Scaber J,Ansorge O,Talbot K
Tue Oct 28 00:00:00 UTC 2008
TDP-43 expression in mouse models of amyotrophic lateral sclerosis and spinal muscular atrophy.
BMC neuroscience
Turner BJ,Bäumer D,Parkinson NJ,Scaber J,Ansorge O,Talbot K
Tue Oct 28 00:00:00 UTC 2008
Neuropathologic classification of dementias: introduction.
Handbook of clinical neurology
Duyckaerts C
Tue Dec 07 00:00:00 UTC 2010
Neuropathologic classification of dementias: introduction.
Handbook of clinical neurology
Duyckaerts C
Tue Dec 07 00:00:00 UTC 2010
Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis.
PLoS genetics
Rutherford NJ,Zhang YJ,Baker M,Gass JM,Finch NA,Xu YF,Stewart H,Kelley BJ,Kuntz K,Crook RJ,Sreedharan J,Vance C,Sorenson E,Lippa C,Bigio EH,Geschwind DH,Knopman DS,Mitsumoto H,Petersen RC,Cashman NR,Hutton M,Shaw CE,Boylan KB,Boeve B,Graff-Radford NR,Wszolek ZK,Caselli RJ,Dickson DW,Mackenzie IR,Petrucelli L,Rademakers R
Fri Sep 19 00:00:00 UTC 2008
Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis.
PLoS genetics
Rutherford NJ,Zhang YJ,Baker M,Gass JM,Finch NA,Xu YF,Stewart H,Kelley BJ,Kuntz K,Crook RJ,Sreedharan J,Vance C,Sorenson E,Lippa C,Bigio EH,Geschwind DH,Knopman DS,Mitsumoto H,Petersen RC,Cashman NR,Hutton M,Shaw CE,Boylan KB,Boeve B,Graff-Radford NR,Wszolek ZK,Caselli RJ,Dickson DW,Mackenzie IR,Petrucelli L,Rademakers R
Fri Sep 19 00:00:00 UTC 2008
Increase in the relative expression of tau with four microtubule binding repeat regions in frontotemporal lobar degeneration and progressive supranuclear palsy brains.
Acta neuropathologica
Ingelsson M,Ramasamy K,Russ C,Freeman SH,Orne J,Raju S,Matsui T,Growdon JH,Frosch MP,Ghetti B,Brown RH,Irizarry MC,Hyman BT
Thu Nov 01 00:00:00 UTC 2007
Increase in the relative expression of tau with four microtubule binding repeat regions in frontotemporal lobar degeneration and progressive supranuclear palsy brains.
Acta neuropathologica
Ingelsson M,Ramasamy K,Russ C,Freeman SH,Orne J,Raju S,Matsui T,Growdon JH,Frosch MP,Ghetti B,Brown RH,Irizarry MC,Hyman BT
Thu Nov 01 00:00:00 UTC 2007
Ubiquitinated pathological lesions in frontotemporal lobar degeneration contain the TAR DNA-binding protein, TDP-43.
Acta neuropathologica
Davidson Y,Kelley T,Mackenzie IR,Pickering-Brown S,Du Plessis D,Neary D,Snowden JS,Mann DM
Tue May 01 00:00:00 UTC 2007
Ubiquitinated pathological lesions in frontotemporal lobar degeneration contain the TAR DNA-binding protein, TDP-43.
Acta neuropathologica
Davidson Y,Kelley T,Mackenzie IR,Pickering-Brown S,Du Plessis D,Neary D,Snowden JS,Mann DM
Tue May 01 00:00:00 UTC 2007
Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases.
Acta neuropathologica
Nakashima-Yasuda H,Uryu K,Robinson J,Xie SX,Hurtig H,Duda JE,Arnold SE,Siderowf A,Grossman M,Leverenz JB,Woltjer R,Lopez OL,Hamilton R,Tsuang DW,Galasko D,Masliah E,Kaye J,Clark CM,Montine TJ,Lee VM,Trojanowski JQ
Sat Sep 01 00:00:00 UTC 2007
Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases.
Acta neuropathologica
Nakashima-Yasuda H,Uryu K,Robinson J,Xie SX,Hurtig H,Duda JE,Arnold SE,Siderowf A,Grossman M,Leverenz JB,Woltjer R,Lopez OL,Hamilton R,Tsuang DW,Galasko D,Masliah E,Kaye J,Clark CM,Montine TJ,Lee VM,Trojanowski JQ
Sat Sep 01 00:00:00 UTC 2007
TDP-43 in differential diagnosis of motor neuron disorders.
Acta neuropathologica
Dickson DW,Josephs KA,Amador-Ortiz C
Sun Jul 01 00:00:00 UTC 2007
TDP-43 in differential diagnosis of motor neuron disorders.
Acta neuropathologica
Dickson DW,Josephs KA,Amador-Ortiz C
Sun Jul 01 00:00:00 UTC 2007
TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation.
Acta neuropathologica
Tan CF,Eguchi H,Tagawa A,Onodera O,Iwasaki T,Tsujino A,Nishizawa M,Kakita A,Takahashi H
Tue May 01 00:00:00 UTC 2007
TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation.
Acta neuropathologica
Tan CF,Eguchi H,Tagawa A,Onodera O,Iwasaki T,Tsujino A,Nishizawa M,Kakita A,Takahashi H
Tue May 01 00:00:00 UTC 2007
TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation.
Acta neuropathologica
Tan CF,Eguchi H,Tagawa A,Onodera O,Iwasaki T,Tsujino A,Nishizawa M,Kakita A,Takahashi H
Tue May 01 00:00:00 UTC 2007
Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in frontotemporal lobar degeneration.
Acta neuropathologica
Neumann M,Igaz LM,Kwong LK,Nakashima-Yasuda H,Kolb SJ,Dreyfuss G,Kretzschmar HA,Trojanowski JQ,Lee VM
Tue May 01 00:00:00 UTC 2007
Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in frontotemporal lobar degeneration.
Acta neuropathologica
Neumann M,Igaz LM,Kwong LK,Nakashima-Yasuda H,Kolb SJ,Dreyfuss G,Kretzschmar HA,Trojanowski JQ,Lee VM
Tue May 01 00:00:00 UTC 2007
Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in frontotemporal lobar degeneration.
Acta neuropathologica
Neumann M,Igaz LM,Kwong LK,Nakashima-Yasuda H,Kolb SJ,Dreyfuss G,Kretzschmar HA,Trojanowski JQ,Lee VM
Tue May 01 00:00:00 UTC 2007
Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in frontotemporal lobar degeneration.
Acta neuropathologica
Neumann M,Igaz LM,Kwong LK,Nakashima-Yasuda H,Kolb SJ,Dreyfuss G,Kretzschmar HA,Trojanowski JQ,Lee VM
Tue May 01 00:00:00 UTC 2007
Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in frontotemporal lobar degeneration.
Acta neuropathologica
Neumann M,Igaz LM,Kwong LK,Nakashima-Yasuda H,Kolb SJ,Dreyfuss G,Kretzschmar HA,Trojanowski JQ,Lee VM
Tue May 01 00:00:00 UTC 2007
TDP-43 is deposited in the Guam parkinsonism-dementia complex brains.
Brain : a journal of neurology
Hasegawa M,Arai T,Akiyama H,Nonaka T,Mori H,Hashimoto T,Yamazaki M,Oyanagi K
Tue May 01 00:00:00 UTC 2007
TDP-43 is deposited in the Guam parkinsonism-dementia complex brains.
Brain : a journal of neurology
Hasegawa M,Arai T,Akiyama H,Nonaka T,Mori H,Hashimoto T,Yamazaki M,Oyanagi K
Tue May 01 00:00:00 UTC 2007
TDP-43 is deposited in the Guam parkinsonism-dementia complex brains.
Brain : a journal of neurology
Hasegawa M,Arai T,Akiyama H,Nonaka T,Mori H,Hashimoto T,Yamazaki M,Oyanagi K
Tue May 01 00:00:00 UTC 2007
TDP-43 is deposited in the Guam parkinsonism-dementia complex brains.
Brain : a journal of neurology
Hasegawa M,Arai T,Akiyama H,Nonaka T,Mori H,Hashimoto T,Yamazaki M,Oyanagi K
Tue May 01 00:00:00 UTC 2007
TDP-43 is deposited in the Guam parkinsonism-dementia complex brains.
Brain : a journal of neurology
Hasegawa M,Arai T,Akiyama H,Nonaka T,Mori H,Hashimoto T,Yamazaki M,Oyanagi K
Tue May 01 00:00:00 UTC 2007
A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology.
Brain : a journal of neurology
Leverenz JB,Yu CE,Montine TJ,Steinbart E,Bekris LM,Zabetian C,Kwong LK,Lee VM,Schellenberg GD,Bird TD
Tue May 01 00:00:00 UTC 2007
A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology.
Brain : a journal of neurology
Leverenz JB,Yu CE,Montine TJ,Steinbart E,Bekris LM,Zabetian C,Kwong LK,Lee VM,Schellenberg GD,Bird TD
Tue May 01 00:00:00 UTC 2007
A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology.
Brain : a journal of neurology
Leverenz JB,Yu CE,Montine TJ,Steinbart E,Bekris LM,Zabetian C,Kwong LK,Lee VM,Schellenberg GD,Bird TD
Tue May 01 00:00:00 UTC 2007
A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology.
Brain : a journal of neurology
Leverenz JB,Yu CE,Montine TJ,Steinbart E,Bekris LM,Zabetian C,Kwong LK,Lee VM,Schellenberg GD,Bird TD
Tue May 01 00:00:00 UTC 2007
Frontotemporal lobar degeneration with upper motor neuron disease/ primary lateral sclerosis.
Neurology
Josephs KA,Dickson DW
Tue Oct 30 00:00:00 UTC 2007
Frontotemporal lobar degeneration with upper motor neuron disease/ primary lateral sclerosis.
Neurology
Josephs KA,Dickson DW
Tue Oct 30 00:00:00 UTC 2007
Clinicopathologic features of frontotemporal dementia with progranulin sequence variation.
Neurology
Spina S,Murrell JR,Huey ED,Wassermann EM,Pietrini P,Baraibar MA,Barbeito AG,Troncoso JC,Vidal R,Ghetti B,Grafman J
Tue Mar 13 00:00:00 UTC 2007
Clinicopathologic features of frontotemporal dementia with progranulin sequence variation.
Neurology
Spina S,Murrell JR,Huey ED,Wassermann EM,Pietrini P,Baraibar MA,Barbeito AG,Troncoso JC,Vidal R,Ghetti B,Grafman J
Tue Mar 13 00:00:00 UTC 2007
A 34-year-old man with progressive behavioral and language disturbance.
Neurology
Miller BL,Josephs KA,Parisi JE,Keegan BM
Tue Jan 02 00:00:00 UTC 2007
A 34-year-old man with progressive behavioral and language disturbance.
Neurology
Miller BL,Josephs KA,Parisi JE,Keegan BM
Tue Jan 02 00:00:00 UTC 2007
Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations.
Annals of neurology
Mackenzie IR,Bigio EH,Ince PG,Geser F,Neumann M,Cairns NJ,Kwong LK,Forman MS,Ravits J,Stewart H,Eisen A,McClusky L,Kretzschmar HA,Monoranu CM,Highley JR,Kirby J,Siddique T,Shaw PJ,Lee VM,Trojanowski JQ
Tue May 01 00:00:00 UTC 2007
Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations.
Annals of neurology
Mackenzie IR,Bigio EH,Ince PG,Geser F,Neumann M,Cairns NJ,Kwong LK,Forman MS,Ravits J,Stewart H,Eisen A,McClusky L,Kretzschmar HA,Monoranu CM,Highley JR,Kirby J,Siddique T,Shaw PJ,Lee VM,Trojanowski JQ
Tue May 01 00:00:00 UTC 2007
Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations.
Annals of neurology
Mackenzie IR,Bigio EH,Ince PG,Geser F,Neumann M,Cairns NJ,Kwong LK,Forman MS,Ravits J,Stewart H,Eisen A,McClusky L,Kretzschmar HA,Monoranu CM,Highley JR,Kirby J,Siddique T,Shaw PJ,Lee VM,Trojanowski JQ
Tue May 01 00:00:00 UTC 2007
Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations.
Annals of neurology
Mackenzie IR,Bigio EH,Ince PG,Geser F,Neumann M,Cairns NJ,Kwong LK,Forman MS,Ravits J,Stewart H,Eisen A,McClusky L,Kretzschmar HA,Monoranu CM,Highley JR,Kirby J,Siddique T,Shaw PJ,Lee VM,Trojanowski JQ
Tue May 01 00:00:00 UTC 2007
Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations.
Annals of neurology
Mackenzie IR,Bigio EH,Ince PG,Geser F,Neumann M,Cairns NJ,Kwong LK,Forman MS,Ravits J,Stewart H,Eisen A,McClusky L,Kretzschmar HA,Monoranu CM,Highley JR,Kirby J,Siddique T,Shaw PJ,Lee VM,Trojanowski JQ
Tue May 01 00:00:00 UTC 2007
TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease.
Annals of neurology
Amador-Ortiz C,Lin WL,Ahmed Z,Personett D,Davies P,Duara R,Graff-Radford NR,Hutton ML,Dickson DW
Tue May 01 00:00:00 UTC 2007
TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease.
Annals of neurology
Amador-Ortiz C,Lin WL,Ahmed Z,Personett D,Davies P,Duara R,Graff-Radford NR,Hutton ML,Dickson DW
Tue May 01 00:00:00 UTC 2007
TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease.
Annals of neurology
Amador-Ortiz C,Lin WL,Ahmed Z,Personett D,Davies P,Duara R,Graff-Radford NR,Hutton ML,Dickson DW
Tue May 01 00:00:00 UTC 2007
TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease.
Annals of neurology
Amador-Ortiz C,Lin WL,Ahmed Z,Personett D,Davies P,Duara R,Graff-Radford NR,Hutton ML,Dickson DW
Tue May 01 00:00:00 UTC 2007
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease.
The Journal of cell biology
Filimonenko M,Stuffers S,Raiborg C,Yamamoto A,Malerød L,Fisher EM,Isaacs A,Brech A,Stenmark H,Simonsen A
Mon Nov 05 00:00:00 UTC 2007
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease.
The Journal of cell biology
Filimonenko M,Stuffers S,Raiborg C,Yamamoto A,Malerød L,Fisher EM,Isaacs A,Brech A,Stenmark H,Simonsen A
Mon Nov 05 00:00:00 UTC 2007
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease.
The Journal of cell biology
Filimonenko M,Stuffers S,Raiborg C,Yamamoto A,Malerød L,Fisher EM,Isaacs A,Brech A,Stenmark H,Simonsen A
Mon Nov 05 00:00:00 UTC 2007
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease.
The Journal of cell biology
Filimonenko M,Stuffers S,Raiborg C,Yamamoto A,Malerød L,Fisher EM,Isaacs A,Brech A,Stenmark H,Simonsen A
Mon Nov 05 00:00:00 UTC 2007
Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhang YJ,Xu YF,Dickey CA,Buratti E,Baralle F,Bailey R,Pickering-Brown S,Dickson D,Petrucelli L
Wed Sep 26 00:00:00 UTC 2007
Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhang YJ,Xu YF,Dickey CA,Buratti E,Baralle F,Bailey R,Pickering-Brown S,Dickson D,Petrucelli L
Wed Sep 26 00:00:00 UTC 2007
Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhang YJ,Xu YF,Dickey CA,Buratti E,Baralle F,Bailey R,Pickering-Brown S,Dickson D,Petrucelli L
Wed Sep 26 00:00:00 UTC 2007
Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhang YJ,Xu YF,Dickey CA,Buratti E,Baralle F,Bailey R,Pickering-Brown S,Dickson D,Petrucelli L
Wed Sep 26 00:00:00 UTC 2007
Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhang YJ,Xu YF,Dickey CA,Buratti E,Baralle F,Bailey R,Pickering-Brown S,Dickson D,Petrucelli L
Wed Sep 26 00:00:00 UTC 2007
TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions.
The American journal of pathology
Cairns NJ,Neumann M,Bigio EH,Holm IE,Troost D,Hatanpaa KJ,Foong C,White CL,Schneider JA,Kretzschmar HA,Carter D,Taylor-Reinwald L,Paulsmeyer K,Strider J,Gitcho M,Goate AM,Morris JC,Mishra M,Kwong LK,Stieber A,Xu Y,Forman MS,Trojanowski JQ,Lee VM,Mackenzie IR
Sun Jul 01 00:00:00 UTC 2007
TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions.
The American journal of pathology
Cairns NJ,Neumann M,Bigio EH,Holm IE,Troost D,Hatanpaa KJ,Foong C,White CL,Schneider JA,Kretzschmar HA,Carter D,Taylor-Reinwald L,Paulsmeyer K,Strider J,Gitcho M,Goate AM,Morris JC,Mishra M,Kwong LK,Stieber A,Xu Y,Forman MS,Trojanowski JQ,Lee VM,Mackenzie IR
Sun Jul 01 00:00:00 UTC 2007
Concurrence of TDP-43, tau and alpha-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies.
Brain research
Higashi S,Iseki E,Yamamoto R,Minegishi M,Hino H,Fujisawa K,Togo T,Katsuse O,Uchikado H,Furukawa Y,Kosaka K,Arai H
Wed Dec 12 00:00:00 UTC 2007
Concurrence of TDP-43, tau and alpha-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies.
Brain research
Higashi S,Iseki E,Yamamoto R,Minegishi M,Hino H,Fujisawa K,Togo T,Katsuse O,Uchikado H,Furukawa Y,Kosaka K,Arai H
Wed Dec 12 00:00:00 UTC 2007
Concurrence of TDP-43, tau and alpha-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies.
Brain research
Higashi S,Iseki E,Yamamoto R,Minegishi M,Hino H,Fujisawa K,Togo T,Katsuse O,Uchikado H,Furukawa Y,Kosaka K,Arai H
Wed Dec 12 00:00:00 UTC 2007
Nuclear protein profiling of Jurkat cells during heat stress-induced apoptosis by 2-DE and MS/MS.
Electrophoresis
Yuan X,Kuramitsu Y,Furumoto H,Zhang X,Hayashi E,Fujimoto M,Nakamura K
Fri Jun 01 00:00:00 UTC 2007
Nuclear protein profiling of Jurkat cells during heat stress-induced apoptosis by 2-DE and MS/MS.
Electrophoresis
Yuan X,Kuramitsu Y,Furumoto H,Zhang X,Hayashi E,Fujimoto M,Nakamura K
Fri Jun 01 00:00:00 UTC 2007
Lack of TDP-43 abnormalities in mutant SOD1 transgenic mice shows disparity with ALS.
Neuroscience letters
Robertson J,Sanelli T,Xiao S,Yang W,Horne P,Hammond R,Pioro EP,Strong MJ
Wed Jun 13 00:00:00 UTC 2007
Lack of TDP-43 abnormalities in mutant SOD1 transgenic mice shows disparity with ALS.
Neuroscience letters
Robertson J,Sanelli T,Xiao S,Yang W,Horne P,Hammond R,Pioro EP,Strong MJ
Wed Jun 13 00:00:00 UTC 2007
Lack of TDP-43 abnormalities in mutant SOD1 transgenic mice shows disparity with ALS.
Neuroscience letters
Robertson J,Sanelli T,Xiao S,Yang W,Horne P,Hammond R,Pioro EP,Strong MJ
Wed Jun 13 00:00:00 UTC 2007
Appearance pattern of TDP-43 in Japanese frontotemporal lobar degeneration with ubiquitin-positive inclusions.
Neuroscience letters
Higashi S,Iseki E,Yamamoto R,Minegishi M,Hino H,Fujisawa K,Togo T,Katsuse O,Uchikado H,Furukawa Y,Kosaka K,Arai H
Mon Jun 04 00:00:00 UTC 2007
Appearance pattern of TDP-43 in Japanese frontotemporal lobar degeneration with ubiquitin-positive inclusions.
Neuroscience letters
Higashi S,Iseki E,Yamamoto R,Minegishi M,Hino H,Fujisawa K,Togo T,Katsuse O,Uchikado H,Furukawa Y,Kosaka K,Arai H
Mon Jun 04 00:00:00 UTC 2007
A reassessment of the neuropathology of frontotemporal dementia linked to chromosome 3.
Journal of neuropathology and experimental neurology
Holm IE,Englund E,Mackenzie IR,Johannsen P,Isaacs AM
Mon Oct 01 00:00:00 UTC 2007
A reassessment of the neuropathology of frontotemporal dementia linked to chromosome 3.
Journal of neuropathology and experimental neurology
Holm IE,Englund E,Mackenzie IR,Johannsen P,Isaacs AM
Mon Oct 01 00:00:00 UTC 2007
TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusions.
Journal of neuropathology and experimental neurology
Neumann M,Kwong LK,Truax AC,Vanmassenhove B,Kretzschmar HA,Van Deerlin VM,Clark CM,Grossman M,Miller BL,Trojanowski JQ,Lee VM
Thu Mar 01 00:00:00 UTC 2007
TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusions.
Journal of neuropathology and experimental neurology
Neumann M,Kwong LK,Truax AC,Vanmassenhove B,Kretzschmar HA,Van Deerlin VM,Clark CM,Grossman M,Miller BL,Trojanowski JQ,Lee VM
Thu Mar 01 00:00:00 UTC 2007
TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusions.
Journal of neuropathology and experimental neurology
Neumann M,Kwong LK,Truax AC,Vanmassenhove B,Kretzschmar HA,Van Deerlin VM,Clark CM,Grossman M,Miller BL,Trojanowski JQ,Lee VM
Thu Mar 01 00:00:00 UTC 2007
TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusions.
Journal of neuropathology and experimental neurology
Neumann M,Kwong LK,Truax AC,Vanmassenhove B,Kretzschmar HA,Van Deerlin VM,Clark CM,Grossman M,Miller BL,Trojanowski JQ,Lee VM
Thu Mar 01 00:00:00 UTC 2007
Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations.
Journal of neuropathology and experimental neurology
Josephs KA,Ahmed Z,Katsuse O,Parisi JF,Boeve BF,Knopman DS,Petersen RC,Davies P,Duara R,Graff-Radford NR,Uitti RJ,Rademakers R,Adamson J,Baker M,Hutton ML,Dickson DW
Thu Feb 01 00:00:00 UTC 2007
Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations.
Journal of neuropathology and experimental neurology
Josephs KA,Ahmed Z,Katsuse O,Parisi JF,Boeve BF,Knopman DS,Petersen RC,Davies P,Duara R,Graff-Radford NR,Uitti RJ,Rademakers R,Adamson J,Baker M,Hutton ML,Dickson DW
Thu Feb 01 00:00:00 UTC 2007
Corticobasal syndrome associated with the A9D Progranulin mutation.
Journal of neuropathology and experimental neurology
Spina S,Murrell JR,Huey ED,Wassermann EM,Pietrini P,Grafman J,Ghetti B
Mon Oct 01 00:00:00 UTC 2007
Corticobasal syndrome associated with the A9D Progranulin mutation.
Journal of neuropathology and experimental neurology
Spina S,Murrell JR,Huey ED,Wassermann EM,Pietrini P,Grafman J,Ghetti B
Mon Oct 01 00:00:00 UTC 2007
TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations.
Journal of neuropathology and experimental neurology
Neumann M,Mackenzie IR,Cairns NJ,Boyer PJ,Markesbery WR,Smith CD,Taylor JP,Kretzschmar HA,Kimonis VE,Forman MS
Thu Feb 01 00:00:00 UTC 2007
TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations.
Journal of neuropathology and experimental neurology
Neumann M,Mackenzie IR,Cairns NJ,Boyer PJ,Markesbery WR,Smith CD,Taylor JP,Kretzschmar HA,Kimonis VE,Forman MS
Thu Feb 01 00:00:00 UTC 2007
TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations.
Journal of neuropathology and experimental neurology
Neumann M,Mackenzie IR,Cairns NJ,Boyer PJ,Markesbery WR,Smith CD,Taylor JP,Kretzschmar HA,Kimonis VE,Forman MS
Thu Feb 01 00:00:00 UTC 2007
TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations.
Journal of neuropathology and experimental neurology
Neumann M,Mackenzie IR,Cairns NJ,Boyer PJ,Markesbery WR,Smith CD,Taylor JP,Kretzschmar HA,Kimonis VE,Forman MS
Thu Feb 01 00:00:00 UTC 2007
TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations.
Journal of neuropathology and experimental neurology
Neumann M,Mackenzie IR,Cairns NJ,Boyer PJ,Markesbery WR,Smith CD,Taylor JP,Kretzschmar HA,Kimonis VE,Forman MS
Thu Feb 01 00:00:00 UTC 2007
Evidence that TDP-43 is not the major ubiquitinated target within the pathological inclusions of amyotrophic lateral sclerosis.
Journal of neuropathology and experimental neurology
Sanelli T,Xiao S,Horne P,Bilbao J,Zinman L,Robertson J
Sat Dec 01 00:00:00 UTC 2007
Evidence that TDP-43 is not the major ubiquitinated target within the pathological inclusions of amyotrophic lateral sclerosis.
Journal of neuropathology and experimental neurology
Sanelli T,Xiao S,Horne P,Bilbao J,Zinman L,Robertson J
Sat Dec 01 00:00:00 UTC 2007
Progressive anomia revisited: focal degeneration associated with progranulin gene mutation.
Neurocase
Snowden JS,Pickering-Brown SM,Du Plessis D,Mackenzie IR,Varma A,Mann DM,Neary D
Mon Oct 01 00:00:00 UTC 2007
Progressive anomia revisited: focal degeneration associated with progranulin gene mutation.
Neurocase
Snowden JS,Pickering-Brown SM,Du Plessis D,Mackenzie IR,Varma A,Mann DM,Neary D
Mon Oct 01 00:00:00 UTC 2007
Alzheimer and Parkinson diagnoses in progranulin null mutation carriers in an extended founder family.
Archives of neurology
Brouwers N,Nuytemans K,van der Zee J,Gijselinck I,Engelborghs S,Theuns J,Kumar-Singh S,Pickut BA,Pals P,Dermaut B,Bogaerts V,De Pooter T,Serneels S,Van den Broeck M,Cuijt I,Mattheijssens M,Peeters K,Sciot R,Martin JJ,Cras P,Santens P,Vandenberghe R,De Deyn PP,Cruts M,Van Broeckhoven C,Sleegers K
Mon Oct 01 00:00:00 UTC 2007
Alzheimer and Parkinson diagnoses in progranulin null mutation carriers in an extended founder family.
Archives of neurology
Brouwers N,Nuytemans K,van der Zee J,Gijselinck I,Engelborghs S,Theuns J,Kumar-Singh S,Pickut BA,Pals P,Dermaut B,Bogaerts V,De Pooter T,Serneels S,Van den Broeck M,Cuijt I,Mattheijssens M,Peeters K,Sciot R,Martin JJ,Cras P,Santens P,Vandenberghe R,De Deyn PP,Cruts M,Van Broeckhoven C,Sleegers K
Mon Oct 01 00:00:00 UTC 2007
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Science (New York, N.Y.)
Neumann M,Sampathu DM,Kwong LK,Truax AC,Micsenyi MC,Chou TT,Bruce J,Schuck T,Grossman M,Clark CM,McCluskey LF,Miller BL,Masliah E,Mackenzie IR,Feldman H,Feiden W,Kretzschmar HA,Trojanowski JQ,Lee VM
Fri Oct 06 00:00:00 UTC 2006
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Science (New York, N.Y.)
Neumann M,Sampathu DM,Kwong LK,Truax AC,Micsenyi MC,Chou TT,Bruce J,Schuck T,Grossman M,Clark CM,McCluskey LF,Miller BL,Masliah E,Mackenzie IR,Feldman H,Feiden W,Kretzschmar HA,Trojanowski JQ,Lee VM
Fri Oct 06 00:00:00 UTC 2006
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Science (New York, N.Y.)
Neumann M,Sampathu DM,Kwong LK,Truax AC,Micsenyi MC,Chou TT,Bruce J,Schuck T,Grossman M,Clark CM,McCluskey LF,Miller BL,Masliah E,Mackenzie IR,Feldman H,Feiden W,Kretzschmar HA,Trojanowski JQ,Lee VM
Fri Oct 06 00:00:00 UTC 2006
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Science (New York, N.Y.)
Neumann M,Sampathu DM,Kwong LK,Truax AC,Micsenyi MC,Chou TT,Bruce J,Schuck T,Grossman M,Clark CM,McCluskey LF,Miller BL,Masliah E,Mackenzie IR,Feldman H,Feiden W,Kretzschmar HA,Trojanowski JQ,Lee VM
Fri Oct 06 00:00:00 UTC 2006
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Science (New York, N.Y.)
Neumann M,Sampathu DM,Kwong LK,Truax AC,Micsenyi MC,Chou TT,Bruce J,Schuck T,Grossman M,Clark CM,McCluskey LF,Miller BL,Masliah E,Mackenzie IR,Feldman H,Feiden W,Kretzschmar HA,Trojanowski JQ,Lee VM
Fri Oct 06 00:00:00 UTC 2006
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Science (New York, N.Y.)
Neumann M,Sampathu DM,Kwong LK,Truax AC,Micsenyi MC,Chou TT,Bruce J,Schuck T,Grossman M,Clark CM,McCluskey LF,Miller BL,Masliah E,Mackenzie IR,Feldman H,Feiden W,Kretzschmar HA,Trojanowski JQ,Lee VM
Fri Oct 06 00:00:00 UTC 2006
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Science (New York, N.Y.)
Neumann M,Sampathu DM,Kwong LK,Truax AC,Micsenyi MC,Chou TT,Bruce J,Schuck T,Grossman M,Clark CM,McCluskey LF,Miller BL,Masliah E,Mackenzie IR,Feldman H,Feiden W,Kretzschmar HA,Trojanowski JQ,Lee VM
Fri Oct 06 00:00:00 UTC 2006
TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Biochemical and biophysical research communications
Arai T,Hasegawa M,Akiyama H,Ikeda K,Nonaka T,Mori H,Mann D,Tsuchiya K,Yoshida M,Hashizume Y,Oda T
Fri Dec 22 00:00:00 UTC 2006
TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Biochemical and biophysical research communications
Arai T,Hasegawa M,Akiyama H,Ikeda K,Nonaka T,Mori H,Mann D,Tsuchiya K,Yoshida M,Hashizume Y,Oda T
Fri Dec 22 00:00:00 UTC 2006
TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Biochemical and biophysical research communications
Arai T,Hasegawa M,Akiyama H,Ikeda K,Nonaka T,Mori H,Mann D,Tsuchiya K,Yoshida M,Hashizume Y,Oda T
Fri Dec 22 00:00:00 UTC 2006
TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Biochemical and biophysical research communications
Arai T,Hasegawa M,Akiyama H,Ikeda K,Nonaka T,Mori H,Mann D,Tsuchiya K,Yoshida M,Hashizume Y,Oda T
Fri Dec 22 00:00:00 UTC 2006
