Search
Invitrogen
TEM5 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-50672
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a region derived from internal residues of human G protein-coupled receptor 124
Conjugate
Form
Liquid
Concentration
1.2 mg/mL
Amount
120 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects endogenous levels of total GPR124 / TEM5 protein.
Target Information
Tumor endothelial markers (TEMs) are significantly up-regulated during angiogenesis and neoangiogensis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies. These include TEMs such as TEM1, TEM5, TEM7 and TEM8. TEM5 is a member of the adhesion family of G protein coupled receptors and is localized on the surface of endothelial cells. TEM5 is a seven-pass transmembrane receptor, unlike TEM1, TEM7 and TEM8 which span the membrane once. TEM5 is abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon. Proteolytically processed soluble TEM5 mediates endothelial cell survival during angiogenesis by linking integrin to glycosaminoglycans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Adhesion G protein-coupled receptor A2; DKFZp434C211; DKFZp434J0911; FLJ14390; G protein-coupled receptor 124; G-protein coupled receptor 124; seven-pass transmembrane protein; Tumor endothelial marker 5; unnamed protein product
Gene Aliases: 8430414O08Rik; 9530074E10Rik; ADGRA2; GPR124; KIAA1531; mKIAA1531; TEM5
UniProt ID: (Human) Q96PE1, (Mouse) Q91ZV8
Entrez Gene ID: (Human) 25960, (Mouse) 78560
angiogenesis
sprouting angiogenesis
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
central nervous system development
positive regulation of endothelial cell migration
Wnt signaling pathway
endothelial cell migration
regulation of angiogenesis
regulation of chemotaxis
canonical Wnt signaling pathway
regulation of establishment of blood-brain barrier
positive regulation of canonical Wnt signaling pathway
negative regulation of vascular endothelial growth factor signaling pathway
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support