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Invitrogen
TENM2 Polyclonal Antibody
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FIGURE: 1 / 3
TENM2 Antibody (PA5-47638) in IHC (F)
Immunohistochemical analysis of TENM2 in immersion fixed frozen sections of embryonic mouse brain. Samples were incubated in TENM2 polyclonal antibody (Product # PA5-47638) using a dilution of 10 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Sheep HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Specific staining was localized to neurons in dorsal root gang... View More
Product Details
PA5-47638
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant human Teneurin-2 Met1-Lys183
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs, approximately 15% cross-reactivity with recombinant human (rh) Teneurin-3 is observed, and less than 4% cross-reactivity with rhTeneurin-1 is observed.
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
Target Information
Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion. May function as a cellular signal transducer. Isoform 2: Acts as a ligand of the ADGRL1 receptor. Mediates axon guidance and heterophilic cell-cell adhesion. {ECO:0000269 PubMed:21724987}. Ten-2 intracellular domain: Induces gene transcription inhibition. {ECO:0000250}.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Neurestin; neurestin alpha; odd Oz/ten-m homolog 2; odz, odd Oz/ten-m homolog 2; Protein Odd Oz/ten-m homolog 2; Ten-2; Ten-m2; Tenascin-M2; Teneurin transmembrane protein 2; Teneurin-2
Gene Aliases: KIAA1127; Lasso; ODZ2; Odz3; Ten-2; TEN-M2; TENM2; TNM2
UniProt ID: (Human) Q9NT68, (Rat) Q9R1K2
Entrez Gene ID: (Human) 57451, (Rat) 117242, (Mouse) 23964
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
axon guidance
central nervous system development
single organismal cell-cell adhesion
calcium-mediated signaling using intracellular calcium source
positive regulation of filopodium assembly
self proteolysis
regulation of transcription, DNA-templated
cell adhesion
signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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