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Product Details
PA5-20354
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 20 amino acid peptide from near the amino terminus of human TP1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11156390
Product Specific Information
A suggested positive control is human kidney tissue lysate.
PA5-20354 can be used with blocking peptide PEP-0474.
Target Information
Telomerase is an RNA-dependent DNA polymerase that uses an RNA component to add telomeric repeat sequences at the ends of chromosomes. Besides the RNA component which serves as the template that specifies the telomeric repeat, the telomerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the telomerase-associated protein 1 (TP1). Telomerase activity is low in most somatic cells, causing the gradual shortening of telomeres which can ultimately lead to telomere fusion and cell death. High levels of telomerase activity are widely seen in cancerous cells and while recent experiments have suggested that telomerase may be a viable target in cancer therapy, expression levels of TP1 do not correlate with malignancy. At least two isoforms of TP1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: p230; p240; p80 homolog; p80 telomerase homolog; rTLP1; Telomerase protein 1; Telomerase protein component 1; Telomerase-associated protein 1; TROVE domain family, member 1
Gene Aliases: p240; TEP1; TLP1; TP1; TROVE1; VAULT2
UniProt ID: (Human) Q99973, (Mouse) P97499, (Rat) O08653
Entrez Gene ID: (Human) 7011, (Mouse) 21745, (Rat) 64523
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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