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TERT Polyclonal Antibody

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TERT Polyclonal Antibody

Product Details

BS-0233R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300
-

Immunohistochemistry (Paraffin) (IHC (P))

1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

Flow Cytometry (Flow)

1:20-1:100
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human TERT, amino acids 601-750.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase (TERT) have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HEST2; hTERT; Telomerase catalytic subunit; Telomerase reverse transcriptase; telomerase reverse transcriptase beta; Telomerase-associated protein 2; tert {ECO:0000312|RGD:70494}; TP2; unnamed protein product

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Gene Aliases: CMM9; DKCA2; DKCB4; EST2; hEST2; hTRT; PFBMFT1; TCS1; TERT; TP2; TR; TRT

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UniProt ID: (Human) O14746, (Rat) Q673L6, (Mouse) O70372

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Entrez Gene ID: (Human) 7015, (Rat) 301965, (Mouse) 21752

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Function(s)
tRNA binding transcription coactivator binding DNA binding telomerase activity RNA binding RNA-directed DNA polymerase activity RNA-directed RNA polymerase activity protein binding transferase activity nucleotidyltransferase activity DNA polymerase activity telomeric DNA binding identical protein binding protein homodimerization activity metal ion binding chaperone binding telomerase RNA binding template-free RNA nucleotidyltransferase telomerase RNA reverse transcriptase activity DNA metabolism protein nucleic acid metabolism protein
Process(es)
telomere maintenance via recombination telomere maintenance transcription, RNA-templated RNA-dependent DNA biosynthetic process protein import into nucleus telomere maintenance via telomerase mitochondrion organization heart development DNA strand elongation positive regulation of Wnt signaling pathway production of siRNA involved in RNA interference regulation of protein stability positive regulation of hair cycle negative regulation of apoptotic process negative regulation of neuron apoptotic process positive regulation of angiogenesis positive regulation of glucose import response to cadmium ion establishment of protein localization to telomere cellular response to hypoxia DNA biosynthetic process replicative senescence siRNA transcription positive regulation of G1/S transition of mitotic cell cycle positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of transdifferentiation positive regulation of vascular smooth muscle cell proliferation positive regulation of protein localization to nucleolus positive regulation of vascular associated smooth muscle cell migration negative regulation of endothelial cell apoptotic process positive regulation of stem cell proliferation negative regulation of cellular senescence negative regulation of extrinsic apoptotic signaling pathway in absence of ligand obsolete age-dependent telomere shortening biological_process negative regulation of gene expression telomere formation via telomerase positive regulation of nitric-oxide synthase activity negative regulation of production of siRNA involved in RNA interference RNA biosynthetic process
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