Immunogen sequence: TNTETHPAKDE TFWKRKSRAR KSLFQKNLMG RKVKSLDLSI TQQKWKQSVD RPELRRSLSQ QPQDTFDLEE VQSNSEEEQS QSRWPSRPRH PHHHQT
Highest antigen sequence identity to the following orthologs - mouse 25%, rat 26%.
TESPA1 is a critical component of the TCR signalosome and is essential for T cell selection and maturation through the regulation of TCR signaling during T cell development. TESPA1 encodes a protein of 458 amino acids and is highly conserved among vertebrate species. TESPA1 expression was tightly regulated during T cell development, with highest expression at the DP stage. TESPA1 deficiency resulted in failure of positive selection and substantially fewer of CD4+ and CD8+ SP cells in the thymus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HSPC257; KIAA0748; Protein TESPA1; Thymocyte-expressed positive selection-associated protein 1
Gene Aliases: HSPC257; KIAA0748; TESPA1
UniProt ID: (Human) A2RU30
Entrez Gene ID: (Human) 9840