TESPA1 is a critical component of the TCR signalosome and is essential for T cell selection and maturation through the regulation of TCR signaling during T cell development. TESPA1 encodes a protein of 458 amino acids and is highly conserved among vertebrate species. TESPA1 expression was tightly regulated during T cell development, with highest expression at the DP stage. TESPA1 deficiency resulted in failure of positive selection and substantially fewer of CD4+ and CD8+ SP cells in the thymus.
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Protein Aliases: Protein TESPA1; Thymocyte-expressed positive selection-associated protein 1
Gene Aliases: 5830405N20Rik; A430001F24Rik; AI450549; HSPC257; KIAA0748; TESPA1