Immunogen sequence: VPPNPIATFN APSKWPEPQS TVSYGLAVQG AIQILPLGSG HTPQSSSNSE KNSLPPVMAI SNVENEKQVH ISFLPANTQG FPLAPERGLF HASLGIAQLS QAGPSKSDRG SSQVSVTSTV HVVNTTVVTM PVPMVSTSSS SYTT
Highest antigen sequence identity to the following orthologs: Mouse - 46%, Rat - 47%.
Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CXXC finger 6; CXXC zinc finger 6; CXXC-type zinc finger protein 6; Leukemia-associated protein with a CXXC domain; Methylcytosine dioxygenase TET1; RP11-119F7.1; Ten-eleven translocation 1 gene protein; ten-eleven translocation-1; tet oncogene 1; TET1 splice variant VP_DE4; TET1 splice variant VP_DE456
Gene Aliases: bA119F7.1; CXXC6; KIAA1676; LCX; MLL-TET1; TET1; TET1-MLL
UniProt ID: (Human) Q8NFU7
Entrez Gene ID: (Human) 80312