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Proteintech
TET2 Polyclonal Antibody
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Product Details
21207-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TET2 Fusion Protein Ag15583 (1-350 aa encoded by BC150180)
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody recognizes all three isoforms of TET2.
Immunogen sequence: MEQDRTNHV EGNRLSPFLI PSPPICQTER LATKLQNGSP LPERAHPEVN GDTKWHSFKS YYGIPCMKGS QNSRVSPDFT QESRGYSKCL QNGGIKRTVS EPSLSGLLQI KKLKQDQKAN GERRNFGVSQ ERNPGESSQP NVSDLSDKKE SVSSVAQENA VKDFTSFSTH NCSGPENPEL QILNEQEGKS ANYHDKNIVL LKNKAVLMPN GATVSASSVE HTHGELLEKT LSQYYPDCVS IAVQKTTSHI NAINSQATNE LSCEITHPSH TSGQINSAQT SNSELPPKPA AVVSEACDAD DADNASKLAA MLNTCSFQKP EQLQQQKSVF EICPSPAENN IQGTTKLASG E (1-350 aa encoded by BC150180)
Target Information
TET2 is a dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydromethylcytosine (5hmC) and plays a key role in active DNA demethylation. TET2 has a preference for 5-hydroxymethylcytosine in CpG motifs. It mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC) and conversion of 5fC to 5-carboyxlcytosine (5caC). Conversion of 5mC into 5hmC, 5fC, and 5caC probably constitutes the first step in cytonsine demethylation. In addition to TET2's role in DNA demethylation, it is also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Mutations in the genes can result in Polycythemia vera and Myelodysplastic syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ20032; Methylcytosine dioxygenase TET2; MGC125715; OTTHUMP00000161869; probable methylcytosine dioxygenase TET2; Protein Ayu17 449; Protein Ayu17-449; Tet 2; tet oncogene 2; tet oncogene family member 2
Gene Aliases: Ayu17-449; E130014J05Rik; KIAA1546; MDS; mKIAA1546; Nbla00191; TET2
UniProt ID: (Human) Q6N021, (Mouse) Q4JK59
Entrez Gene ID: (Human) 54790, (Mouse) 214133
kidney development
myeloid progenitor cell differentiation
5-methylcytosine catabolic process
protein O-linked glycosylation
cell cycle
post-embryonic development
response to organic cyclic compound
cytosine metabolic process
hemoglobin metabolic process
myeloid cell differentiation
positive regulation of transcription from RNA polymerase II promoter
spleen development
oxidation-reduction process
hematopoietic stem cell homeostasis
liver morphogenesis
DNA demethylation
histone H3-K4 trimethylation
chromatin modification
5-methylcytosine metabolic process
hemopoiesis
homeostasis of number of cells
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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