Proteintech

TET2 Polyclonal Antibody

TET2 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 11

TET2 Antibody (21207-1-AP) in ICC/IF

Immunofluorescent analysis of ( 4% PFA) fixed Neuro-2a cells using 21207-1-AP (TET2 antibody) at dilution of 1:50 and Alexa Fluor 488-Conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

TET2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

TET2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

21207-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 39 publications 39 publications

Immunohistochemistry (IHC)

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 10 publications 10 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

ChIP assay (ChIP)

Assay-dependent

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TET2 Fusion Protein Ag15583 (1-350 aa encoded by BC150180)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody recognizes all three isoforms of TET2.

Immunogen sequence: MEQDRTNHV EGNRLSPFLI PSPPICQTER LATKLQNGSP LPERAHPEVN GDTKWHSFKS YYGIPCMKGS QNSRVSPDFT QESRGYSKCL QNGGIKRTVS EPSLSGLLQI KKLKQDQKAN GERRNFGVSQ ERNPGESSQP NVSDLSDKKE SVSSVAQENA VKDFTSFSTH NCSGPENPEL QILNEQEGKS ANYHDKNIVL LKNKAVLMPN GATVSASSVE HTHGELLEKT LSQYYPDCVS IAVQKTTSHI NAINSQATNE LSCEITHPSH TSGQINSAQT SNSELPPKPA AVVSEACDAD DADNASKLAA MLNTCSFQKP EQLQQQKSVF EICPSPAENN IQGTTKLASG E (1-350 aa encoded by BC150180)

Target Information

TET2 is a dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydromethylcytosine (5hmC) and plays a key role in active DNA demethylation. TET2 has a preference for 5-hydroxymethylcytosine in CpG motifs. It mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC) and conversion of 5fC to 5-carboyxlcytosine (5caC). Conversion of 5mC into 5hmC, 5fC, and 5caC probably constitutes the first step in cytonsine demethylation. In addition to TET2’s role in DNA demethylation, it is also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Mutations in the genes can result in Polycythemia vera and Myelodysplastic syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A small-molecule degrader of TET3 as treatment for anorexia nervosa in an animal model.

Proceedings of the National Academy of Sciences of the United States of America

Lv H,Catarino J,Li D,Liu B,Gao XB,Horvath TL,Huang Y

Tue Apr 18 00:00:00 UTC 2023

A small-molecule degrader of TET3 as treatment for anorexia nervosa in an animal model.

Proceedings of the National Academy of Sciences of the United States of America

Lv H,Catarino J,Li D,Liu B,Gao XB,Horvath TL,Huang Y

Tue Apr 18 00:00:00 UTC 2023

Enhanced BPGM/2,3-DPG pathway activity suppresses glycolysis in hypoxic astrocytes via FIH-1 and TET2.

Brain research bulletin

E G,Sun B,Liu B,Xu G,He S,Wang Y,Feng L,Wei H,Zhang J,Chen J,Gao Y,Zhang E

Sun Jan 01 00:00:00 UTC 2023

TET2 confers a mechanistic link of microRNA-210 and mtROS in hypoxia-suppressed spontaneous transient outward currents in uterine arteries of pregnant sheep.

The Journal of physiology

Hu XQ,Song R,Dasgupta C,Blood AB,Zhang L

Sat Apr 01 00:00:00 UTC 2023

m⁵C-dependent cross-regulation between nuclear reader ALYREF and writer NSUN2 promotes urothelial bladder cancer malignancy through facilitating RABL6/TK1 mRNAs splicing and stabilization.

Cell death & disease

Wang N,Chen RX,Deng MH,Wei WS,Zhou ZH,Ning K,Li YH,Li XD,Ye YL,Wen JH,Dong B,Zhang XP,Liu ZW,Zhou FJ

Sat Feb 18 00:00:00 UTC 2023

Ascorbic acid induces salivary gland function through TET2/acetylcholine receptor signaling in aging SAMP1/Klotho (-/-) mice.

Aging

Toan NK,Kim SA,Ahn SG

Thu Aug 11 00:00:00 UTC 2022

TET2 Regulates 5-Hydroxymethylcytosine Signature and CD4⁺ T-Cell Balance in Allergic Rhinitis.

Allergy, asthma & immunology research

Tan L,Fu L,Zheng L,Fan W,Tan H,Tao Z,Xu Y

Tue Mar 01 00:00:00 UTC 2022

RNA 5-Methylcytosine Regulators Contribute to Metabolism Heterogeneity and Predict Prognosis in Ovarian Cancer.

Frontiers in cell and developmental biology

Xu J,Liu X,Chen Y,Wang Y,Liu T,Yi P

Tue Apr 05 00:00:00 UTC 2022

ROS attenuates TET2-dependent ZO-1 epigenetic expression in cerebral vascular endothelial cells.

Fluids and barriers of the CNS

Wang L,Mao B,Fan K,Sun R,Zhang J,Liang H,Liu Y

Thu Sep 08 00:00:00 UTC 2022

TET2 regulates immune tolerance in chronically activated mast cells.

JCI insight

Rigo R,Chelbi R,Agopian J,Letard S,Griffon A,Ghamlouch H,Vernerey J,Ladopoulos V,Voisset E,De Sepulveda P,Guittard G,Nunès JA,Bidaut G,Göttgens B,Weber M,Bernard OA,Dubreuil P,Soucie E

Fri Apr 08 00:00:00 UTC 2022

Ascorbic acid 2-glucoside preconditioning enhances the ability of bone marrow mesenchymal stem cells in promoting wound healing.

Stem cell research & therapy

Yi Y,Wu M,Zhou X,Xiong M,Tan Y,Yu H,Liu Z,Wu Y,Zhang Q

Mon Mar 21 00:00:00 UTC 2022

HIF-1α mediates renal fibrosis by regulating metabolic remodeling of renal tubule epithelial cells.

Biochemical and biophysical research communications

Liu D,Sun H,Li K,Zhao Z,Liu Z,Zhang G,Ge Y,Zhang J,Wang D,Leng Y

Sat Aug 27 00:00:00 UTC 2022

HIF-1α mediates renal fibrosis by regulating metabolic remodeling of renal tubule epithelial cells.

Biochemical and biophysical research communications

Liu D,Sun H,Li K,Zhao Z,Liu Z,Zhang G,Ge Y,Zhang J,Wang D,Leng Y

Sat Aug 27 00:00:00 UTC 2022

HIF-1α mediates renal fibrosis by regulating metabolic remodeling of renal tubule epithelial cells.

Biochemical and biophysical research communications

Liu D,Sun H,Li K,Zhao Z,Liu Z,Zhang G,Ge Y,Zhang J,Wang D,Leng Y

Sat Aug 27 00:00:00 UTC 2022

HIF-1α mediates renal fibrosis by regulating metabolic remodeling of renal tubule epithelial cells.

Biochemical and biophysical research communications

Liu D,Sun H,Li K,Zhao Z,Liu Z,Zhang G,Ge Y,Zhang J,Wang D,Leng Y

Sat Aug 27 00:00:00 UTC 2022

Inhibition of NF-κB is required for oleanolic acid to downregulate PD-L1 by promoting DNA demethylation in gastric cancer cells.

Journal of biochemical and molecular toxicology

Lu X,Li Y,Yang W,Tao M,Dai Y,Xu J,Xu Q

Fri Jan 01 00:00:00 UTC 2021

Experimental eye research / short communication format characterization of DNA hydroxymethylation in the ocular choroid.

Experimental eye research

Pomerleau J,Weidmann C,Coutant K,Lowry CM,Veilleux MP,Bérubé J,Wagner JR,Landreville S

Thu Apr 01 00:00:00 UTC 2021

Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons.

Nature communications

Traube FR,Özdemir D,Sahin H,Scheel C,Glück AF,Geserich AS,Oganesian S,Kostidis S,Iwan K,Rahimoff R,Giorgio G,Müller M,Spada F,Biel M,Cox J,Giera M,Michalakis S,Carell T

Fri Jul 02 00:00:00 UTC 2021

MgFe-LDH Nanoparticles: A Promising Leukemia Inhibitory Factor Replacement for Self-Renewal and Pluripotency Maintenance in Cultured Mouse Embryonic Stem Cells.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

He X,Zhu Y,Yang L,Wang Z,Wang Z,Feng J,Wen X,Cheng L,Zhu R

Sat May 01 00:00:00 UTC 2021

The chromosomal protein SMCHD1 regulates DNA methylation and the 2c-like state of embryonic stem cells by antagonizing TET proteins.

Science advances

Huang Z,Yu J,Cui W,Johnson BK,Kim K,Pfeifer GP

Fri Jan 01 00:00:00 UTC 2021

Hepatic glycogenolysis is determined by maternal high-calorie diet via methylation of Pygl and it is modified by oteocalcin administration in mice.

Molecular metabolism

Kawakubo-Yasukochi T,Yano E,Kimura S,Nishinakagawa T,Mizokami A,Hayashi Y,Hatakeyama Y,Ohe K,Yasukochi A,Nakamura S,Jimi E,Hirata M

Wed Dec 01 00:00:00 UTC 2021

DNA demethylase Tet2 suppresses cisplatin-induced acute kidney injury.

Cell death discovery

Bao Y,Bai M,Zhu H,Yuan Y,Wang Y,Zhang Y,Wang J,Xie X,Yao X,Mao J,Fu X,Chen J,Yang Y,Lin W

Thu Jun 17 00:00:00 UTC 2021

Low shear stress induced vascular endothelial cell pyroptosis by TET2/SDHB/ROS pathway.

Free radical biology & medicine

Chen J,Zhang J,Wu J,Zhang S,Liang Y,Zhou B,Wu P,Wei D

Fri Jan 01 00:00:00 UTC 2021

Loss of ten-eleven translocation 2 induces cardiac hypertrophy and fibrosis through modulating ERK signaling pathway.

Human molecular genetics

Tao H,Xu W,Qu W,Gao H,Zhang J,Cheng X,Liu N,Chen J,Xu GL,Li X,Shu Q

Sat May 29 00:00:00 UTC 2021

Demethylation of HACE1 gene promoter by propofol promotes autophagy of human A549 cells.

Oncology letters

Li S,Yang H,Zhao M,Gong L,Wang Y,Lv Z,Quan Y,Wang Z

Tue Dec 01 00:00:00 UTC 2020

Restoration of TET2 deficiency inhibits tumor growth in head neck squamous cell carcinoma.

Annals of translational medicine

Huang R,Wang Y,Ge H,Wang D,Wang Y,Zhang W,Yang J,Cheng J

Sun Mar 01 00:00:00 UTC 2020

Restoration of TET2 deficiency inhibits tumor growth in head neck squamous cell carcinoma.

Annals of translational medicine

Huang R,Wang Y,Ge H,Wang D,Wang Y,Zhang W,Yang J,Cheng J

Sun Mar 01 00:00:00 UTC 2020

Proteases Activate Pregnancy Neutrophils by a Protease-Activated Receptor 1 Pathway: Epigenetic Implications for Preeclampsia.

Reproductive sciences (Thousand Oaks, Calif.)

Walsh SW,Nugent WH,Al Dulaimi M,Washington SL,Dacha P,Strauss JF

Sun Nov 01 00:00:00 UTC 2020

Proteases Activate Pregnancy Neutrophils by a Protease-Activated Receptor 1 Pathway: Epigenetic Implications for Preeclampsia.

Reproductive sciences (Thousand Oaks, Calif.)

Walsh SW,Nugent WH,Al Dulaimi M,Washington SL,Dacha P,Strauss JF

Sun Nov 01 00:00:00 UTC 2020

Neuroprotective Effect of Piracetam against Cocaine-Induced Neuro Epigenetic Modification of DNA Methylation in Astrocytes.

Brain sciences

Sivalingam K,Samikkannu T

Sat Sep 05 00:00:00 UTC 2020

Protease Amplification of the Inflammatory Response Induced by Commensal Bacteria: Implications for Racial Disparity in Term and Preterm Birth.

Reproductive sciences (Thousand Oaks, Calif.)

Walsh SW,Nugent WH,Alam SMK,Washington SL,Teves M,Jefferson KK,Strauss JF

Wed Jan 01 00:00:00 UTC 2020

Protease Amplification of the Inflammatory Response Induced by Commensal Bacteria: Implications for Racial Disparity in Term and Preterm Birth.

Reproductive sciences (Thousand Oaks, Calif.)

Walsh SW,Nugent WH,Alam SMK,Washington SL,Teves M,Jefferson KK,Strauss JF

Wed Jan 01 00:00:00 UTC 2020

Developmental nicotine exposure engenders intergenerational downregulation and aberrant posttranslational modification of cardinal epigenetic factors in the frontal cortices, striata, and hippocampi of adolescent mice.

Epigenetics & chromatin

Buck JM,O'Neill HC,Stitzel JA

Thu Mar 05 00:00:00 UTC 2020

Empagliflozin Alleviates Hepatic Steatosis by Activating the AMPK-TET2-Autophagy Pathway in vivo and in vitro.

Frontiers in pharmacology

Li T,Fang T,Xu L,Liu X,Li X,Xue M,Yu X,Sun B,Chen L

Wed Feb 10 00:00:00 UTC 2021

Empagliflozin Alleviates Hepatic Steatosis by Activating the AMPK-TET2-Autophagy Pathway in vivo and in vitro.

Frontiers in pharmacology

Li T,Fang T,Xu L,Liu X,Li X,Xue M,Yu X,Sun B,Chen L

Wed Feb 10 00:00:00 UTC 2021

Empagliflozin Alleviates Hepatic Steatosis by Activating the AMPK-TET2-Autophagy Pathway in vivo and in vitro.

Frontiers in pharmacology

Li T,Fang T,Xu L,Liu X,Li X,Xue M,Yu X,Sun B,Chen L

Wed Feb 10 00:00:00 UTC 2021

Reduction of Tet2 exacerbates early stage Alzheimer's pathology and cognitive impairments in 2×Tg-AD mice.

Human molecular genetics

Li L,Qiu Y,Miao M,Liu Z,Li W,Zhu Y,Wang Q

Tue Jul 21 00:00:00 UTC 2020

TET-Mediated Hypermethylation Primes SDH-Deficient Cells for HIF2α-Driven Mesenchymal Transition.

Cell reports

Morin A,Goncalves J,Moog S,Castro-Vega LJ,Job S,Buffet A,Fontenille MJ,Woszczyk J,Gimenez-Roqueplo AP,Letouzé E,Favier J

Tue Mar 31 00:00:00 UTC 2020

TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity.

The Journal of experimental medicine

Sun X,Cui Y,Feng H,Liu H,Liu X

Mon Dec 02 00:00:00 UTC 2019

Aanat Knockdown and Melatonin Supplementation in Embryo Development: Involvement of Mitochondrial Function and DNA Methylation.

Antioxidants & redox signaling

Yang M,Tao J,Wu H,Guan S,Liu L,Zhang L,Deng S,He C,Ji P,Liu J,Liu G

Thu Jun 20 00:00:00 UTC 2019

Aanat Knockdown and Melatonin Supplementation in Embryo Development: Involvement of Mitochondrial Function and DNA Methylation.

Antioxidants & redox signaling

Yang M,Tao J,Wu H,Guan S,Liu L,Zhang L,Deng S,He C,Ji P,Liu J,Liu G

Thu Jun 20 00:00:00 UTC 2019

Reprogramming of DNA methylation at NEUROD2-bound sequences during cortical neuron differentiation.

Science advances

Hahn MA,Jin SG,Li AX,Liu J,Huang Z,Wu X,Kim BW,Johnson J,Bilbao AV,Tao S,Yim JA,Fong Y,Goebbels S,Schwab MH,Lu Q,Pfeifer GP

Tue Oct 01 00:00:00 UTC 2019

TET2 facilitates PPARγ agonist-mediated gene regulation and insulin sensitization in adipocytes.

Metabolism: clinical and experimental

Bian F,Ma X,Villivalam SD,You D,Choy LR,Paladugu A,Fung S,Kang S

Sat Dec 01 00:00:00 UTC 2018

Pregnancy-Induced Physiologic Adaptation of the Abdominal Aorta Is Associated with Changes in Gene Expression and Genomic Methylation.

Journal of vascular research

Gelinne A,Brown L,Ko NL,Osol G,Brown S

Mon Sep 16 00:00:00 UTC 2019

Pregnancy-Induced Physiologic Adaptation of the Abdominal Aorta Is Associated with Changes in Gene Expression and Genomic Methylation.

Journal of vascular research

Gelinne A,Brown L,Ko NL,Osol G,Brown S

Mon Sep 16 00:00:00 UTC 2019

The oncogene Etv5 promotes MET in somatic reprogramming and orchestrates epiblast/primitive endoderm specification during mESCs differentiation.

Cell death & disease

Zhang J,Cao H,Xie J,Fan C,Xie Y,He X,Liao M,Zhang S,Wang H

Wed Feb 14 00:00:00 UTC 2018

The oncogene Etv5 promotes MET in somatic reprogramming and orchestrates epiblast/primitive endoderm specification during mESCs differentiation.

Cell death & disease

Zhang J,Cao H,Xie J,Fan C,Xie Y,He X,Liao M,Zhang S,Wang H

Wed Feb 14 00:00:00 UTC 2018

Decrease of 5-hydroxymethylcytosine and TET1 with nuclear exclusion of TET2 in small intestinal neuroendocrine tumors.

BMC cancer

Barazeghi E,Prabhawa S,Norlén O,Hellman P,Stålberg P,Westin G

Wed Jul 25 00:00:00 UTC 2018

Decrease of 5-hydroxymethylcytosine and TET1 with nuclear exclusion of TET2 in small intestinal neuroendocrine tumors.

BMC cancer

Barazeghi E,Prabhawa S,Norlén O,Hellman P,Stålberg P,Westin G

Wed Jul 25 00:00:00 UTC 2018

Decrease of 5-hydroxymethylcytosine and TET1 with nuclear exclusion of TET2 in small intestinal neuroendocrine tumors.

BMC cancer

Barazeghi E,Prabhawa S,Norlén O,Hellman P,Stålberg P,Westin G

Wed Jul 25 00:00:00 UTC 2018

Decrease of 5-hydroxymethylcytosine and TET1 with nuclear exclusion of TET2 in small intestinal neuroendocrine tumors.

BMC cancer

Barazeghi E,Prabhawa S,Norlén O,Hellman P,Stålberg P,Westin G

Wed Jul 25 00:00:00 UTC 2018

Hypermethylation of the Micro-RNA 145 Promoter Is the Key Regulator for NLRP3 Inflammasome-Induced Activation and Plaque Formation.

JACC. Basic to translational science

Zhong W,Li B,Xu Y,Yang P,Chen R,Wang Z,Shao C,Song J,Yan J

Mon Oct 01 00:00:00 UTC 2018

Hypermethylation of the Micro-RNA 145 Promoter Is the Key Regulator for NLRP3 Inflammasome-Induced Activation and Plaque Formation.

JACC. Basic to translational science

Zhong W,Li B,Xu Y,Yang P,Chen R,Wang Z,Shao C,Song J,Yan J

Mon Oct 01 00:00:00 UTC 2018

Ten-eleven translocation 2 demethylates the MMP9 promoter, and its down-regulation in preeclampsia impairs trophoblast migration and invasion.

The Journal of biological chemistry

Li X,Wu C,Shen Y,Wang K,Tang L,Zhou M,Yang M,Pan T,Liu X,Xu W

Fri Jun 29 00:00:00 UTC 2018

Ten-eleven translocation 2 demethylates the MMP9 promoter, and its down-regulation in preeclampsia impairs trophoblast migration and invasion.

The Journal of biological chemistry

Li X,Wu C,Shen Y,Wang K,Tang L,Zhou M,Yang M,Pan T,Liu X,Xu W

Fri Jun 29 00:00:00 UTC 2018

Restricted TET2 Expression in Germinal Center Type B Cells Promotes Stringent Epstein-Barr Virus Latency.

Journal of virology

Wille CK,Li Y,Rui L,Johannsen EC,Kenney SC

Wed Mar 01 00:00:00 UTC 2017

Coordinate Regulation of TET2 and EBNA2 Controls the DNA Methylation State of Latent Epstein-Barr Virus.

Journal of virology

Lu F,Wiedmer A,Martin KA,Wickramasinghe PJMS,Kossenkov AV,Lieberman PM

Sun Oct 15 00:00:00 UTC 2017

Coordinate Regulation of TET2 and EBNA2 Controls the DNA Methylation State of Latent Epstein-Barr Virus.

Journal of virology

Lu F,Wiedmer A,Martin KA,Wickramasinghe PJMS,Kossenkov AV,Lieberman PM

Sun Oct 15 00:00:00 UTC 2017

Coordinate Regulation of TET2 and EBNA2 Controls the DNA Methylation State of Latent Epstein-Barr Virus.

Journal of virology

Lu F,Wiedmer A,Martin KA,Wickramasinghe PJMS,Kossenkov AV,Lieberman PM

Sun Oct 15 00:00:00 UTC 2017

Coordinate Regulation of TET2 and EBNA2 Controls the DNA Methylation State of Latent Epstein-Barr Virus.

Journal of virology

Lu F,Wiedmer A,Martin KA,Wickramasinghe PJMS,Kossenkov AV,Lieberman PM

Sun Oct 15 00:00:00 UTC 2017

A role for TET2 in parathyroid carcinoma.

Endocrine-related cancer

Barazeghi E,Gill AJ,Sidhu S,Norlén O,Dina R,Palazzo FF,Hellman P,Stålberg P,Westin G

Sat Jul 01 00:00:00 UTC 2017

A role for TET2 in parathyroid carcinoma.

Endocrine-related cancer

Barazeghi E,Gill AJ,Sidhu S,Norlén O,Dina R,Palazzo FF,Hellman P,Stålberg P,Westin G

Sat Jul 01 00:00:00 UTC 2017

A role for TET2 in parathyroid carcinoma.

Endocrine-related cancer

Barazeghi E,Gill AJ,Sidhu S,Norlén O,Dina R,Palazzo FF,Hellman P,Stålberg P,Westin G

Sat Jul 01 00:00:00 UTC 2017

A role for TET2 in parathyroid carcinoma.

Endocrine-related cancer

Barazeghi E,Gill AJ,Sidhu S,Norlén O,Dina R,Palazzo FF,Hellman P,Stålberg P,Westin G

Sat Jul 01 00:00:00 UTC 2017

TET2 Protects against oxLDL-Induced HUVEC Dysfunction by Upregulating the CSE/H₂S System.

Frontiers in pharmacology

Peng J,Tang ZH,Ren Z,He B,Zeng Y,Liu LS,Wang Z,Wei DH,Zheng XL,Jiang ZS

Wed Sep 30 00:00:00 UTC 2020

TET2 Protects against oxLDL-Induced HUVEC Dysfunction by Upregulating the CSE/H₂S System.

Frontiers in pharmacology

Peng J,Tang ZH,Ren Z,He B,Zeng Y,Liu LS,Wang Z,Wei DH,Zheng XL,Jiang ZS

Wed Sep 30 00:00:00 UTC 2020

TET2 Protects against oxLDL-Induced HUVEC Dysfunction by Upregulating the CSE/H₂S System.

Frontiers in pharmacology

Peng J,Tang ZH,Ren Z,He B,Zeng Y,Liu LS,Wang Z,Wei DH,Zheng XL,Jiang ZS

Wed Sep 30 00:00:00 UTC 2020

TET2 Protects against oxLDL-Induced HUVEC Dysfunction by Upregulating the CSE/H₂S System.

Frontiers in pharmacology

Peng J,Tang ZH,Ren Z,He B,Zeng Y,Liu LS,Wang Z,Wei DH,Zheng XL,Jiang ZS

Wed Sep 30 00:00:00 UTC 2020

Epigenetic modification differences between fetal fibroblast cells and mesenchymal stem cells of the Arbas Cashmere goat.

Research in veterinary science

Wang X,Wang Z,Wang Q,Wang H,Liang H,Liu D

Sun Oct 01 00:00:00 UTC 2017

Epigenetic modification differences between fetal fibroblast cells and mesenchymal stem cells of the Arbas Cashmere goat.

Research in veterinary science

Wang X,Wang Z,Wang Q,Wang H,Liang H,Liu D

Sun Oct 01 00:00:00 UTC 2017

Non-catalytic roles for TET1 protein negatively regulating neuronal differentiation through srGAP3 in neuroblastoma cells.

Protein & cell

Gao J,Ma Y,Fu HL,Luo Q,Wang Z,Xiao YH,Yang H,Cui DX,Jin WL

Sun May 01 00:00:00 UTC 2016

Non-catalytic roles for TET1 protein negatively regulating neuronal differentiation through srGAP3 in neuroblastoma cells.

Protein & cell

Gao J,Ma Y,Fu HL,Luo Q,Wang Z,Xiao YH,Yang H,Cui DX,Jin WL

Sun May 01 00:00:00 UTC 2016

Oxidized low-density lipoprotein inhibits THP-1-derived macrophage autophagy via TET2 down-regulation.

Lipids

Li G,Peng J,Liu Y,Li X,Yang Q,Li Y,Tang Z,Wang Z,Jiang Z,Wei D

Sun Feb 01 00:00:00 UTC 2015

Oxidized low-density lipoprotein inhibits THP-1-derived macrophage autophagy via TET2 down-regulation.

Lipids

Li G,Peng J,Liu Y,Li X,Yang Q,Li Y,Tang Z,Wang Z,Jiang Z,Wei D

Sun Feb 01 00:00:00 UTC 2015

A Novel Function of TET2 in CNS: Sustaining Neuronal Survival.

International journal of molecular sciences

Mi Y,Gao X,Dai J,Ma Y,Xu L,Jin W

Thu Sep 10 00:00:00 UTC 2015

A Novel Function of TET2 in CNS: Sustaining Neuronal Survival.

International journal of molecular sciences

Mi Y,Gao X,Dai J,Ma Y,Xu L,Jin W

Thu Sep 10 00:00:00 UTC 2015

A Novel Function of TET2 in CNS: Sustaining Neuronal Survival.

International journal of molecular sciences

Mi Y,Gao X,Dai J,Ma Y,Xu L,Jin W

Thu Sep 10 00:00:00 UTC 2015

A Novel Function of TET2 in CNS: Sustaining Neuronal Survival.

International journal of molecular sciences

Mi Y,Gao X,Dai J,Ma Y,Xu L,Jin W

Thu Sep 10 00:00:00 UTC 2015

Dynamics of ten-eleven translocation hydroxylase family proteins and 5-hydroxymethylcytosine in oligodendrocyte differentiation.

Glia

Zhao X,Dai J,Ma Y,Mi Y,Cui D,Ju G,Macklin WB,Jin W

Sun Jun 01 00:00:00 UTC 2014

Dynamics of ten-eleven translocation hydroxylase family proteins and 5-hydroxymethylcytosine in oligodendrocyte differentiation.

Glia

Zhao X,Dai J,Ma Y,Mi Y,Cui D,Ju G,Macklin WB,Jin W

Sun Jun 01 00:00:00 UTC 2014

Dynamics of ten-eleven translocation hydroxylase family proteins and 5-hydroxymethylcytosine in oligodendrocyte differentiation.

Glia

Zhao X,Dai J,Ma Y,Mi Y,Cui D,Ju G,Macklin WB,Jin W

Sun Jun 01 00:00:00 UTC 2014

Dynamics of ten-eleven translocation hydroxylase family proteins and 5-hydroxymethylcytosine in oligodendrocyte differentiation.

Glia

Zhao X,Dai J,Ma Y,Mi Y,Cui D,Ju G,Macklin WB,Jin W

Sun Jun 01 00:00:00 UTC 2014

TET1 exerts its tumor suppressor function by interacting with p53-EZH2 pathway in gastric cancer.

Journal of biomedical nanotechnology

Fu HL,Ma Y,Lu LG,Hou P,Li BJ,Jin WL,Cui DX

Tue Jul 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: FLJ20032; Methylcytosine dioxygenase TET2; MGC125715; OTTHUMP00000161869; probable methylcytosine dioxygenase TET2; Protein Ayu17 449; Protein Ayu17-449; Tet 2; tet oncogene 2; tet oncogene family member 2

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Gene Aliases: Ayu17-449; E130014J05Rik; KIAA1546; MDS; mKIAA1546; Nbla00191; TET2

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UniProt ID: (Human) Q6N021, (Mouse) Q4JK59

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Entrez Gene ID: (Human) 54790, (Mouse) 214133

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Function(s)

DNA binding protein binding ferrous iron binding zinc ion binding methylcytosine dioxygenase activity oxidoreductase activity metal ion binding dioxygenase activity

Process(es)

kidney development myeloid progenitor cell differentiation 5-methylcytosine catabolic process protein O-linked glycosylation cell cycle post-embryonic development response to organic cyclic compound cytosine metabolic process hemoglobin metabolic process myeloid cell differentiation positive regulation of transcription from RNA polymerase II promoter spleen development oxidation-reduction process hematopoietic stem cell homeostasis liver morphogenesis DNA demethylation histone H3-K4 trimethylation chromatin modification 5-methylcytosine metabolic process hemopoiesis homeostasis of number of cells

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TET2 Polyclonal Antibody

TET2 Antibody (21207-1-AP) in ICC/IF

Product Details

21207-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

ChIP assay (ChIP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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