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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 429 and 637 of TET2|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.2M tris glycine, pH 7, with 50% glycerol, 1mM EGTA|
|Contains||0.025% ProClin 300|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|ChIP assay (ChIP)||5 µg|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
KIAA1546; MDS; probable methylcytosine dioxygenase TET2; tet methylcytosine dioxygenase 2; tet oncogene family member 2
KIAA1546; MDS; Nbla00191; TET2