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Abnova
TET3 Polyclonal Antibody, MaxPab™
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Product Details
H00200424-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TET3 (AAH22243.1, 859 a.a. - 1795 a.a.) partial human protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MEERYGEKGK AIRIEKVIYT GKEGKSSRGC PIAKWVIRRH TLEEKLLCLV RHRAGHHCQN AVIVILILAW EGIPRSLGDT LYQELTDTLR KYGNPTSRRC GLNDDRTCAC QGKDPNTCGA SFSFGCSWSM YFNGCKYARS KTPRKFRLAG DNPKEEEVLR KSFQDLATEV APLYKRLAPQ AYQNQVTNEE IAIDCRLGLK EGRPFAGVTA CMDFCAHAHK DQHNLYNGCT VVCTLTKEDN RCVGKIPEDE QLHVLPLYKM ANTDEFGSEE NQNAKVGSGA IQVLTAFPRE VRRLPEPAKS CRQRQLEARK AAAEKKKIQK EKLSTPEKIK QEALELAGIT SDPGLSLKGG LSQQGLKPSL KVEPQNHFSS FKYSGNAVVE SYSVLGNCRP SDPYSMNSVY SYHSYYAQPS LTSVNGFHSK YALPSFSYYG FPSSNPVFPS QFLGPGAWGH SGSSGSFEKK PDLHALHNSL SPAYGGAEFA ELPSQAVPTD AHHPTPHHQQ PAYPGPKEYL LPKAPLLHSV SRDPSPFAQS SNCYNRSIKQ EPVDPLTQAE PVPRDAGKMG KTPLSEVSQN GGPSHLWGQY SGGPSMSPKR TNGVGGSWGV FSSGESPAIV PDKLSSFGAS CLAPSHFTDG QWGLFPGEGQ QAASHSGGRL RGKPWSPCKF GNSTSALAGP SLTEKPWALG AGDFNSALKG SPGFQDKLWN PMKGEEGRIP AAGASQLDRA WQSFGLPLGS SEKLFGALKS EEKLWDPFSL EEGPAEEPPS KGAVKEEKGG GGAEEEEEEL WSDSEHNFLD ENIGGVAVAP AHGSILIECA RRELHATTPL KKPNRCHPTR ISLVFYQHKN LNQPNHGLAL WEAKMKQLAE RARARQEEAA RLGLGQQEAK LYGKKRKWGG TVVAEPQQKE KKGVVPTRQA LAVPTDSAVT VSSYAYTKVT GPYSRWI
Target Information
TET3, a member of the ten-eleven-translocation (TET) family of genes, is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine and is most abundantly expressed in hematopoietic cells. Unlike the related TET2 protein, mutations in TET3 have not been observed in any myeloid malignancies. TET3 has been shown to be involved in the demethylation of zygotic DNA before the first mitosis and has been suggested to be involved in the epigenetic reprogramming of the zygotic paternal DNA following natural fertilization and may also contribute to somatic cell nuclear reprogramming during animal cloning.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: KIAA0401; Methylcytosine dioxygenase TET3; MGC22014; probable methylcytosine dioxygenase TET3; putative methylcytosine dioxygenase; ten-eleven translocation 3; tet oncogene family member 3
Gene Aliases: BEFAHRS; CXXC10; hCG_40738; KIAA0401; TET3
UniProt ID: (Human) O43151
Entrez Gene ID: (Human) 200424
RNA polymerase II core promoter proximal region sequence-specific DNA binding
DNA binding
protein binding
zinc ion binding
methyl-CpG binding
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
metal ion binding
dioxygenase activity
methylcytosine dioxygenase activity
chromatin organization
protein O-linked glycosylation
regulation of gene expression
positive regulation of macromolecule biosynthetic process
regulation of gene expression, epigenetic
hypomethylation of CpG island
DNA demethylation of male pronucleus
positive regulation of transcription from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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