|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide region of human TFAM.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 2% sucrose|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||0.2-8 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
PA1-24435 detects TFAM in Human samples.
PA1-24435 has been successfully used in Western Blot procedures. By Western blot, PA1-24435 detects the ~ 29 kDa TFAM protein.
PA1-24435 immunogen corresponds to Polyclonal antibody from rabbits immunized with a synthetic peptide region of human TFAM.
TFAM a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. Studies in mice have demonstrated that this protein is required to regulate the mitochondrial genome copy number and is essential for embryonic development. A mouse model for Kearns-Sayre syndrome was produced when expression of the gene was eliminated by targeted disruption in heart and muscle cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Endurance exercise as a countermeasure for aging.
PA1-24435 was used in western blot to study the relationship between age-related dysfunctions and physical inactivity.
|Lanza IR,Short DK,Short KR,Raghavakaimal S,Basu R,Joyner MJ,McConnell JP,Nair KS||Diabetes (57:2933)||2008|