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Proteintech

TFB2M Polyclonal Antibody

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View all (9) TFB2M antibodies

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TFB2M Polyclonal Antibody

Product Details

24411-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
View 2 publications 2 publications
Product Specifications

Species Reactivity

Human, Mouse

Published species

Zebrafish

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TFB2M Fusion Protein Ag19687 (176-396 aa encoded by BC003383)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.62 mg/mL

Amount

93 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LGIEAVPWT ADIPLKVVGM FPSRGEKRAL WKLAYDLYSC TSIYKFGRIE VNMFIGEKEF QKLMADPGNP DLYHVLSVIW QLACEIKVLH MEPWSSFDIY TRKGPLENPK RRELLDQLQQ KLYLIQMIPR QNLFTKNLTP MNYNIFFHLL KHCFGRRSAT VIDHLRSLTP LDARDILMQI GKQEDEKVVN MHPQDFKTLF ETIERSKDCA YKWLYDETLE DR (176-396 aa encoded by BC003383)

Target Information

S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Dimethyladenosine transferase 2, mitochondrial; FLJ22661; FLJ23182; h-mtTFB; HCV NS5A-transactivated protein 5; Hepatitis C virus NS5A-transactivated protein 5; house-keeping protein 1; Mitochondrial 12S rRNA dimethylase 2; Mitochondrial transcription factor B2; mTFB2M; mtTFB2; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2; unnamed protein product

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Gene Aliases: h-mtTFB; h-mtTFB2; Hkp1; hTFB2M; mtTFB2; NS5ATP5; TFB2M

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UniProt ID: (Human) Q9H5Q4, (Mouse) Q3TL26

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Entrez Gene ID: (Human) 64216, (Mouse) 15278

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Function(s)
rRNA (adenine-N6,N6-)-dimethyltransferase activity RNA binding methyltransferase activity rRNA (adenine-N6-)-methyltransferase activity transferase activity mitochondrial RNA polymerase binding promoter specificity activity transcription cofactor activity protein C-terminal carboxyl O-methyltransferase activity tRNA (guanine-N2-)-methyltransferase activity C-methyltransferase activity N-methyltransferase activity O-methyltransferase activity S-methyltransferase activity RNA methyltransferase activity mRNA methyltransferase activity tRNA methyltransferase activity protein methyltransferase activity 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity rRNA methyltransferase activity rRNA (uridine-2'-O-)-methyltransferase activity DNA-methyltransferase activity tRNA (guanine-N1-)-methyltransferase activity rRNA (cytosine-C5-)-methyltransferase activity selenocysteine methyltransferase activity arginine N-methyltransferase activity protein-arginine N-methyltransferase activity lysine N-methyltransferase activity protein-lysine N-methyltransferase activity tRNA (uracil) methyltransferase activity tRNA (guanine) methyltransferase activity tRNA (adenine) methyltransferase activity tRNA (cytosine) methyltransferase activity tRNA (cytosine-5-)-methyltransferase activity tRNA (adenine-N1-)-methyltransferase activity rRNA (adenine) methyltransferase activity rRNA (cytosine) methyltransferase activity rRNA (guanine) methyltransferase activity rRNA (uridine) methyltransferase activity protein C-terminal leucine carboxyl O-methyltransferase activity 1-phenanthrol methyltransferase activity protein-arginine N5-methyltransferase activity methylarsonite methyltransferase activity dimethylarsinite methyltransferase activity 4,5-dihydroxybenzo(a)pyrene methyltransferase activity 1-hydroxypyrene methyltransferase activity 1-hydroxy-6-methoxypyrene methyltransferase activity demethylmenaquinone methyltransferase activity cobalt-precorrin-6B C5-methyltransferase activity cobalt-precorrin-7 C15-methyltransferase activity cobalt-precorrin-5B C1-methyltransferase activity cobalt-precorrin-3 C17-methyltransferase activity dimethylamine methyltransferase activity hydroxyneurosporene-O-methyltransferase activity tRNA (adenine-57, 58-N(1)-) methyltransferase activity methylamine-specific methylcobalamin:coenzyme M methyltransferase activity trimethylamine methyltransferase activity methanol-specific methylcobalamin:coenzyme M methyltransferase activity monomethylamine methyltransferase activity poly(A) RNA binding P-methyltransferase activity Se-methyltransferase activity 2-phytyl-1,4-naphthoquinone methyltransferase activity tRNA (uracil-2'-O-)-methyltransferase activity tRNA (cytosine-2'-O-)-methyltransferase activity phosphomethylethanolamine N-methyltransferase activity tRNA (cytosine-3-)-methyltransferase activity rRNA (cytosine-2'-O-)-methyltransferase activity rRNA (cytosine-N4-)-methyltransferase activity trihydroxyferuloyl spermidine O-methyltransferase activity RNA methyltransferase
Process(es)
rRNA modification rRNA processing transcription from mitochondrial promoter transcription initiation from mitochondrial promoter rRNA methylation methylation transcription, DNA-templated regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated
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