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Proteintech
TFE3 Polyclonal Antibody
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Product Details
14480-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TFE3 Fusion Protein Ag5863 (1-350 aa encoded by BC026027)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
37.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSHAAEPAR DGVEASAEGP RAVFVLLEER RPADSAQLLS LNSLLPESGI VADIELENVL DPDSFYELKS QPLPLRSSLP ISLQATPATP ATLSASSSAG GSRTPAMSSS SSSRVLLRQQ LMRAQAQEQE RRERREQAAA APFPSPAPAS PAISVVGVSA GGHTLSRPPP AQVPREVLKV QTHLENPTRY HLQQARRQQV KQYLSTTLGP KLASQALTPP PGPASAQPLP APEAAHTTGP TGSAPNSPMA LLTIGSSSEK EIDDVIDEII SLESSYNDEM LSYLPGGTTG LQLPSTLPVS GNLLDVYSSQ GVATPAITVS NSCPAELPNI KREISETEAK ALLKERQKKD N (1-350 aa encoded by BC026027)
Target Information
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: bHLHe33; Class E basic helix-loop-helix protein 33; mTFE3; transcription factor E family, member A; Transcription factor E3; transcription factor for IgH enhancer; transcription factor for immunoglobulin heavy-chain enhancer 3; unnamed protein product
Gene Aliases: BHLHE33; F830016E06Rik; MRXSPF; RCCP2; RCCX1; RGD1559642; Tcfe3; Tfe-3; TFE3; TFEA
UniProt ID: (Human) P19532, (Mouse) Q64092
Entrez Gene ID: (Human) 7030, (Rat) 317376, (Mouse) 209446
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein dimerization activity
sequence-specific double-stranded DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
molecular_function
transcription regulatory region DNA binding
protein heterodimerization activity
adaptive immune response
immune system process
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
humoral immune response
lysosome organization
regulation of osteoclast differentiation
positive regulation of cell adhesion
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of brown fat cell differentiation
negative regulation of cold-induced thermogenesis
transcription from RNA polymerase II promoter
biological_process
transcription, DNA-templated
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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