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Invitrogen
TGF alpha Polyclonal Antibody
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FIGURE: 1 / 1
TGF alpha Antibody (PA5-80116) in WB
Western blot analysis of TGF alpha in Lane 1: recombinant human TGF a protein, Lane 2: recombinant human TGF a protein, Lane 3: recombinant human TGF a protein using 10, 5 and 2.5 ng, respectively per well. Sample was incubated with TGF alpha (Product # PA5-80116) at a dilution of 0.5 µg/mL.
Product Details
PA5-80116
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human TGF alpha (73-89aa CHSGYVGARCEHADLLA).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide, 0.05mg thimerosal
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
TGF-alpha is an EGF-related polypeptide growth factor that signals through the EGF receptor, and stimulates the proliferation of a wide range of epidermal and epithelial cells. It is produced by monocytes, keratinocytes, and various tumor cells. TGF-alpha induces anchorage-independence transformation in cultured cells. Human, murine and rat TGF-alpha are cross-species reactive. TGFalpha (aa 50) is a growth factor with 33% homology to EGF, binds to EGFR, activates tyrosine phosphorylation of the receptor, and stimulates cell proliferation. It plays a role in tumor initiation by inducing the reversible transformed phenotype.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Protransforming growth factor alpha; TGF a; TGF α; TGF-alpha; TGFalpha; TGFα; Transforming growth factor; transforming growth factor-alpha precursor old gene name 'LU0044C'; unnamed protein product
Gene Aliases: TFGA; TGFA
UniProt ID: (Human) P01135
Entrez Gene ID: (Human) 7039
angiogenesis
cell surface receptor signaling pathway
epidermal growth factor receptor signaling pathway
positive regulation of cell proliferation
intracellular signal transduction
ERBB2-EGFR signaling pathway
positive regulation of MAPK cascade
positive regulation of mitotic nuclear division
positive regulation of epithelial cell proliferation
positive regulation of cell division
mammary gland alveolus development
hepatocyte proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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