Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: GLSTCKTIDM ELVKRKRIEA IRGQILSKLR LASPPSQGEV PPGPLPEAVL ALYNSTRDRV AGESADPEPE PEADYYAKEV TRVLMVDRNN AIYEKTKDIS HSIYMFFNTS DIREAVPEPP LLSRAELRLQ RLKSSVEQHV ELYQKYSNNS WRYLGNRLLT PTDTPEWLSF DVTGVVRQWL NQGDGIQGFR FSAHCSCDSK DNKLHVEING ISPKRRGDLG TIHDMNRPFL LLMATPLERA QHLHSSRHRR ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASASPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS
TGF beta-1 (TGFB1, Transforming Growth Factor Beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues. Transforming growth factor (TGF)-b is stored in the extracellular matrix as a latent complex with its pro-domain. Activation of TGF beta-1 requires the binding of aV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-b binding proteins. Latent forms are complexes of TGF beta-1, an amino-terminal portion of the TGF-beta precursor, designated TGF-LAP (TGF-latency associated peptide), and a specific binding protein, known as LTBP. TGF beta-1 helps regulates proliferation, differentiation, adhesion, migration in many cell types. Many cells have TGF beta receptors, and the protein positively and negatively regulates many other growth factors. TGF beta-1 is cleaved into a latency-associated peptide and a mature TGF beta-1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGF beta-1 homodimer. The mature peptide may also form heterodimers with other TGF beta family members. The gene for TGF beta-1 is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease and cystic fibrosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: regulatory protein; TGF b; TGF b 1; TGF beta; tgf beta 1; TGF beta-1; TGF beta-1 protein; tgf beta1; TGF β; TGF β 1; TGF β1; TGF-B1; TGF-beta 1; TGF-beta 1 protein; TGF-beta-1; TGFβ1; Transforming growth factor; transforming growth factor b1; transforming growth factor beta; transforming growth factor beta-1; Transforming growth factor beta-1 proprotein; transforming growth factor β1; transforming growth factor, beta-1; transforming growth factor-beta 1
Gene Aliases: TGF-beta1; Tgfb; Tgfb-1; Tgfb1; TGFbeta1
UniProt ID: (Rat) P17246, (Mouse) P04202
Entrez Gene ID: (Rat) 59086, (Mouse) 21803
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support