|Tested species reactivity||Human, Mouse, Pig, Rat|
|Published species reactivity||Rat|
|Host / Isotype||Chicken / IgY|
|Immunogen||Peptide based on mouse and human TGFß1 protein (RKPKVEQLSNMIVRS).|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||Assay Dependent|
|Immunohistochemistry (IHC)||Assay Dependent|
|Western Blot (WB)||1:2000-1:5000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|ELISA (ELISA)||See 1 publications below|
PA1-9574 detects TGFb1 in human, mouse and rat samples.
PA1-9574 has been successfully used in Western blot, Immunohistochemistry, Immunocytochemistry, and ELISA procedures. By Western blot, PA1-9574 detects a 25 kDa protein representing TGFb1.
PA1-9574 immunogen is a peptide based on mouse and human TGFb1 protein (RKPKVEQLSNMIVRS).
Store 4c for 1 week and -20c for long term storage.
This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Performance of repetitive tasks induces decreased grip strength and increased fibrogenic proteins in skeletal muscle: role of force and inflammation.
PA1-9574 was used in ELISA to study the mechanism by which repetitive tasks induce decreased grip strength and increased fibrogenic proteins in skeletal muscle
|Abdelmagid SM,Barr AE,Rico M,Amin M,Litvin J,Popoff SN,Safadi FF,Barbe MF||PloS one (7:null)||2012|