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Invitrogen

TGF beta-3 Polyclonal Antibody

View all (19) TGF beta-3 antibodies

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Product Details

PA5-85307

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:10,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human TGF beta 3. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.86 mg/mL

Amount

86 µg

Purification

Antigen affinity chromatography

Storage buffer

0.1M tris glycine, pH 7, with 10% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2792449

Product Specific Information

Keep as concentrated solution.

Predicted reactivity: Mouse (97%), Rat (97%), Pig (87%), Chicken (86%), Rhesus Monkey (100%), Bovine (85%).

Positive Control: mouse placenta, human TGFB3-transfected 293T.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ16571; H-TGF-b-3; prepro-transforming growth factor beta-3; tgf beta 3; TGF-beta-3; Transforming growth factor; transforming growth factor beta-3; Transforming growth factor beta-3 proprotein; transforming growth factor-beta3; unnamed protein product

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Gene Aliases: ARVD; ARVD1; LDS5; RNHF; TGF-beta3; Tgfb-3; TGFB3

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UniProt ID: (Human) P10600

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Entrez Gene ID: (Human) 7043, (Mouse) 21809

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Function(s)
type II transforming growth factor beta receptor binding cytokine activity transforming growth factor beta receptor binding protein binding growth factor activity type I transforming growth factor beta receptor binding type III transforming growth factor beta receptor binding identical protein binding transforming growth factor beta binding protein heterodimerization activity growth factor
Process(es)
response to hypoxia in utero embryonic development transforming growth factor beta receptor signaling pathway salivary gland morphogenesis heart development positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of epithelial to mesenchymal transition negative regulation of macrophage cytokine production mammary gland development response to progesterone positive regulation of collagen biosynthetic process regulation of cell proliferation odontogenesis uterine wall breakdown positive regulation of apoptotic process negative regulation of neuron apoptotic process cell-cell junction organization positive regulation of cell differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter lung alveolus development positive regulation of protein secretion positive regulation of cellular component organization positive regulation of multicellular organismal process positive regulation of filopodium assembly positive regulation of stress fiber assembly positive regulation of cell division face morphogenesis positive regulation of SMAD protein import into nucleus secondary palate development detection of hypoxia cellular response to growth factor stimulus transforming growth factor beta receptor superfamily signaling pathway negative regulation of vascular smooth muscle cell proliferation regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of occluding junction disassembly activation of MAPK activity SMAD protein import into nucleus negative regulation of DNA replication embryo development organ morphogenesis positive regulation of pathway-restricted SMAD protein phosphorylation cell growth negative regulation of transforming growth factor beta receptor signaling pathway growth regulation of MAPK cascade response to estrogen positive regulation of DNA replication cell development embryonic neurocranium morphogenesis palate development SMAD protein signal transduction
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