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Invitrogen

TGF beta-3 Polyclonal Antibody

View all (19) TGF beta-3 antibodies

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TGF beta-3 Polyclonal Antibody

Product Details

PA5-97064

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 25-300 of human TGFB3 (NP_0032301)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.59 mg/mL

Amount

159 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2808866

Product Specific Information

Immunogen sequence: STCTTLDFGH IKKKRVEAIR GQILSKLRLT SPPEPTVMTH VPYQVLALYN STRELLEEMH GEREEGCTQE NTESEYYAKE IHKFDMIQGL AEHNELAVCP KGITSKVFRF NVSSVEKNRT NLFRAEFRVL RVPNPSSKRN EQRIELFQIL RPDEHIAKQR YIGGKNLPTR GTAEWLSFDV TDTVREWLLR RESNLGLEIS IHCPCHTFQP NGDILENIHE VMEIKFKGVD NEDDHGRGDL GRLKKQKDHH NPHLILMMIP PHRLDNPGQG GQRKKR; Positive Samples: BT-474, K-937, Mouse lung, Mouse skeletal muscle, Mouse heart, Rat lung, Rat heart

Target Information

Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ16571; H-TGF-b-3; prepro-transforming growth factor beta-3; tgf beta 3; TGF-beta-3; Transforming growth factor; transforming growth factor beta-3; Transforming growth factor beta-3 proprotein; transforming growth factor-beta3; unnamed protein product

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Gene Aliases: ARVD; ARVD1; LDS5; RNHF; TGF-B3; TGF-beta3; Tgfb-3; TGFB3

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UniProt ID: (Human) P10600, (Rat) Q07258

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Entrez Gene ID: (Human) 7043, (Rat) 25717, (Mouse) 21809

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Function(s)
type II transforming growth factor beta receptor binding cytokine activity transforming growth factor beta receptor binding protein binding growth factor activity type I transforming growth factor beta receptor binding type III transforming growth factor beta receptor binding identical protein binding transforming growth factor beta binding protein heterodimerization activity growth factor
Process(es)
response to hypoxia in utero embryonic development transforming growth factor beta receptor signaling pathway salivary gland morphogenesis heart development positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of epithelial to mesenchymal transition negative regulation of macrophage cytokine production mammary gland development response to progesterone positive regulation of collagen biosynthetic process regulation of cell proliferation odontogenesis uterine wall breakdown positive regulation of apoptotic process negative regulation of neuron apoptotic process cell-cell junction organization positive regulation of cell differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter lung alveolus development positive regulation of protein secretion positive regulation of cellular component organization positive regulation of multicellular organismal process positive regulation of filopodium assembly positive regulation of stress fiber assembly positive regulation of cell division face morphogenesis positive regulation of SMAD protein import into nucleus secondary palate development detection of hypoxia cellular response to growth factor stimulus transforming growth factor beta receptor superfamily signaling pathway negative regulation of vascular smooth muscle cell proliferation regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of occluding junction disassembly activation of MAPK activity SMAD protein import into nucleus female pregnancy aging negative regulation of DNA replication organ morphogenesis positive regulation of pathway-restricted SMAD protein phosphorylation cell growth lung development positive regulation of bone mineralization negative regulation of transforming growth factor beta receptor signaling pathway regulation of epithelial cell differentiation response to laminar fluid shear stress wound healing response to estrogen ossification involved in bone remodeling regulation of endothelial cell differentiation positive regulation of DNA replication cell development digestive tract development embryonic neurocranium morphogenesis inner ear development regulation of epithelial cell proliferation palate development frontal suture morphogenesis SMAD protein signal transduction embryo development growth regulation of MAPK cascade
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