Bioss

TGF beta 3 propeptide Polyclonal Antibody

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TGF beta 3 propeptide Polyclonal Antibody

Product Details

BS-0099R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human TGF-beta 3 propeptide, amino acids 41-90.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ16571; H-TGF-b-3; prepro-transforming growth factor beta-3; tgf beta 3; TGF-beta-3; Transforming growth factor; transforming growth factor beta-3; Transforming growth factor beta-3 proprotein; transforming growth factor, beta 3; unnamed protein product

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Gene Aliases: ARVD; ARVD1; LDS5; RNHF; TGF-B3; TGF-beta3; Tgfb-3; TGFB3

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UniProt ID: (Pig) P15203, (Human) P10600, (Rat) Q07258

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Entrez Gene ID: (Pig) 397400, (Human) 7043, (Rat) 25717, (Mouse) 21809

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Function(s)
type II transforming growth factor beta receptor binding growth factor activity type I transforming growth factor beta receptor binding type III transforming growth factor beta receptor binding identical protein binding transforming growth factor beta binding cytokine activity protein binding protein heterodimerization activity transforming growth factor beta receptor binding growth factor
Process(es)
response to hypoxia transforming growth factor beta receptor signaling pathway salivary gland morphogenesis positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of epithelial to mesenchymal transition negative regulation of macrophage cytokine production positive regulation of bone mineralization response to progesterone positive regulation of collagen biosynthetic process ossification involved in bone remodeling cell-cell junction organization positive regulation of transcription, DNA-templated positive regulation of cell division face morphogenesis secondary palate development detection of hypoxia activation of MAPK activity in utero embryonic development platelet degranulation SMAD protein import into nucleus female pregnancy aging negative regulation of DNA replication positive regulation of pathway-restricted SMAD protein phosphorylation cell growth negative regulation of transforming growth factor beta receptor signaling pathway mammary gland development response to laminar fluid shear stress wound healing regulation of cell proliferation odontogenesis uterine wall breakdown regulation of apoptotic process positive regulation of apoptotic process regulation of MAPK cascade negative regulation of neuron apoptotic process response to estrogen positive regulation of DNA replication positive regulation of transcription from RNA polymerase II promoter lung alveolus development digestive tract development embryonic neurocranium morphogenesis inner ear development positive regulation of protein secretion positive regulation of filopodium assembly positive regulation of stress fiber assembly palate development frontal suture morphogenesis positive regulation of SMAD protein import into nucleus SMAD protein signal transduction regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of occluding junction disassembly organ morphogenesis lung development regulation of epithelial cell differentiation regulation of endothelial cell differentiation cell development regulation of epithelial cell proliferation cellular response to growth factor stimulus embryo development growth
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