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          Disclaimer

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • TGFBR1 Antibodies

          AbboMax

          TGF beta R1 Polyclonal Antibody

          View all (18) TGFBR1 antibodies

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          Cite TGF beta R1 Polyclonal Antibody

          • Antibody Testing Data (2)
          TGF beta R1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          TGF beta R1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 2

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          TGF beta R1 Antibody (500-12344) in IHC (P)

          Immunohistochemistry: Human placenta (FFPE) stained with Rabbit anti-TGFbR1 (Cat# 500-12344) at 1:200 for 10 min @ RT. Staining of formalin-fixed tissue requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          TGF beta R1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          TGF beta R1 Antibody in Western Blot (WB)

          Product Details

          500-12344

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          0.1-1 µg/mL
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          2-10 µg/mL
          -

          Immunoprecipitation (IP)

          2-5 µg/mL
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          A synthetic peptide of human TGFbR1

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.5 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS with proprietary stabilizer

          Contains

          0.01% sodium azide

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Product Specific Information

          Positive control: Transfected HEK293

          Cellular location: Cell membrane.

          Target Information

          TGFBR1 is a transmembrane serine/threonine kinase in the TGFBR1 superfamily, which also includes ACVRs and BMPRs. Upon binding TGF-b, TGFBR2 dimerizes with and activates TGFBR1 via phosphorylation leading to downstream phosphorylation of SMADs by TGFBR1. TGFBR1 forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: activin A receptor type II-like kinase, 53kDa; Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; ALK-5; ESK2; mutant transforming growth factor beta receptor I; ser; Serine/threonine-protein kinase receptor R4; SKR4; tgf beta receptor 1; TGF-beta receptor type I; TGF-beta receptor type-1; TGF-beta type I receptor; TGFR-1; TGFR1; Transfor; transforming growth factor beta receptor I; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I; Transforming growth factor-beta receptor type I

          View more View less

          Gene Aliases: AAT5; ACVRLK4; ALK-5; ALK5; AU017191; ESS1; LDS1; LDS1A; LDS2A; MSSE; SKR4; TbetaR-I; TbetaRI; TGFBR1; TGFR-1

          View more View less

          UniProt ID: (Human) P36897, (Rat) P80204, (Mouse) Q64729

          View more View less

          Entrez Gene ID: (Human) 7046, (Rat) 29591, (Mouse) 21812

          View more View less

          Function(s)
          protein kinase activity protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity transforming growth factor beta receptor activity, type I receptor signaling protein activity type II transforming growth factor beta receptor binding protein binding ATP binding growth factor binding SMAD binding metal ion binding transforming growth factor beta binding I-SMAD binding ubiquitin protein ligase binding protein complex binding protein heterodimerization activity nucleotide binding transmembrane receptor protein serine/threonine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups serine/threonine protein kinase receptor
          Process(es)
          activation of MAPKK activity skeletal system development angiogenesis in utero embryonic development kidney development blastocyst development epithelial to mesenchymal transition negative regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation lens development in camera-type eye ventricular trabecula myocardium morphogenesis ventricular compact myocardium morphogenesis proepicardium development regulation of transcription, DNA-templated protein phosphorylation apoptotic process cell cycle arrest signal transduction transforming growth factor beta receptor signaling pathway heart development positive regulation of cell proliferation germ cell migration male gonad development post-embryonic development anterior/posterior pattern specification regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition positive regulation of pathway-restricted SMAD protein phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation signal transduction by protein phosphorylation collagen fibril organization positive regulation of cell growth positive regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway regulation of protein ubiquitination negative regulation of chondrocyte differentiation activin receptor signaling pathway intracellular signal transduction wound healing endothelial cell activation extracellular structure organization regulation of protein binding endothelial cell migration positive regulation of transcription, DNA-templated thymus development neuron fate commitment embryonic cranial skeleton morphogenesis skeletal system morphogenesis mesenchymal cell differentiation artery morphogenesis cell motility positive regulation of cellular component movement positive regulation of filopodium assembly positive regulation of stress fiber assembly positive regulation of protein kinase B signaling parathyroid gland development palate development pharyngeal system development regulation of cardiac muscle cell proliferation cardiac epithelial to mesenchymal transition pathway-restricted SMAD protein phosphorylation positive regulation of SMAD protein import into nucleus ventricular septum morphogenesis coronary artery morphogenesis response to cholesterol cellular response to transforming growth factor beta stimulus positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of occluding junction disassembly positive regulation of apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway response to hypoxia transmembrane receptor protein serine/threonine kinase signaling pathway embryo implantation aging response to toxic substance regulation of gene expression positive regulation of gene expression response to organic cyclic compound lung development organ regeneration response to prostaglandin E regulation of growth negative regulation of apoptotic process response to estrogen negative regulation of endothelial cell differentiation protein autophosphorylation digestive tract development response to electrical stimulus embryo development phosphorylation cell differentiation
          It has to be done as per old AB suggested Products section.
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