Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Directed against human TGF beta receptor type-1 protein. A BLAST analysis was used to suggest cross-reactivity with the antigen based on 100% homology with the immunizing sequence to mouse, rat, bovine, and wild boar. Cross-reactivity is expected with TGFb1 from non-mammalian sources as only a single amino acid residue change is found within the immunogen sequence from many other organisms.
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).
Protein Aliases: activin A receptor type II-like kinase, 53kDa; Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; ALK-5; ESK2; mutant transforming growth factor beta receptor I; ser; Serine/threonine-protein kinase receptor R4; SKR4; tgf beta receptor 1; TGF-beta receptor type I; TGF-beta receptor type-1; TGF-beta type I receptor; TGFR-1; TGFR1; Transfor; transforming growth factor beta receptor I; transforming growth factor, beta receptor 1; Transforming growth factor-beta receptor type I
Gene Aliases: AAT5; ACVRLK4; ALK-5; ALK5; AU017191; ESS1; LDS1; LDS1A; LDS2A; MSSE; SKR4; TbetaR-I; TbetaRI; TGFBR1; TGFR-1