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          Disclaimer

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • TGF beta-2 Antibodies

          OriGene

          TGFB2 Polyclonal Antibody

          View all (16) TGF beta-2 antibodies

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          Cite TGFB2 Polyclonal Antibody

          • Antibody Testing Data (2)
          TGFB2 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.
          TGFB2 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          FIGURE: 1 / 2

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          TGFB2 Antibody (TA890046) in WB

          HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TGFB2(RC212624, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-TGFB2 r. Positive lysates LY401115 (100 µg) and LC401115 (20 µg) can be purchased separately from OriGene. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          TGFB2 Antibody in Western Blot (WB)
          TGFB2 Antibody in Western Blot (WB)

          Product Details

          TA890046

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:1,000
          -
          Product Specifications

          Species Reactivity

          Human, Mouse

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Recombinant protein of human TGFB2

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          3.25 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C, Avoid Freeze/Thaw Cycles

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          Transforming Growth Factor (TGF) betas mediate many cell to cell interactions that occur during embryonic development. Three TGF betas have been identified in mammals. TGF beta 1, TGF beta 2 and TGF beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecule. The TGF beta polypeptides are multifunctional; capable of influencing cell proliferation, differentiation, and other functions in a wide range of cell types. Transformed, as well as nonneoplastic tissues, release transforming growth factors; and essentially all mammalian cells possess a specific TGF receptor. The multi modal nature of TGF beta is seen in its ability to stimulate or inhibit cellular proliferation. In general, cells of mesenchymal origin appear to be stimulated by TGF beta whereas cells of epithelial or neuroectodermal origin are inhibited by the peptide. TGF beta 1, TGF beta 2, and TGF beta 1.2 appear to be equivalent in biological activity, although there does appear to be differences in binding to certain types of receptors. TGF beta 2 is produced by many cell types and has been found in the highest concentration in porcine platelets and mammalian bone. Latent TGF beta 2 is the prominent isoform found in body fluids such as amniotic fluid, breast milk, and the aqueous and vitreous humor of the eye.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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          Cite this product

          Bioinformatics

          Protein Aliases: BSC-1 cell growth inhibitor; Cetermin; G-TSF; Glioblastoma-derived T-cell suppressor factor; polyergin; prepro-transforming growth factor beta-2; TGF-beta-2; TGFB; TGFβ2; Transforming growth factor; transforming growth factor beta-2; Transforming growth factor beta-2 proprotein; transforming growth factor, beta 2

          View more View less

          Gene Aliases: BB105277; LDS4; TGF-beta2; Tgfb-2; TGFB2

          View more View less

          UniProt ID: (Human) P61812, (Mouse) P27090

          View more View less

          Entrez Gene ID: (Human) 7042, (Mouse) 21808

          View more View less

          Function(s)
          beta-amyloid binding receptor signaling protein serine/threonine kinase activity receptor binding type II transforming growth factor beta receptor binding cytokine activity transforming growth factor beta receptor binding protein binding growth factor activity type III transforming growth factor beta receptor binding protein homodimerization activity protein heterodimerization activity protein N-terminus binding growth factor
          Process(es)
          cell morphogenesis cartilage condensation angiogenesis eye development response to hypoxia epithelial to mesenchymal transition hair follicle development blood vessel remodeling platelet degranulation heart morphogenesis outflow tract septum morphogenesis membranous septum morphogenesis heart valve morphogenesis atrioventricular valve morphogenesis pulmonary valve morphogenesis endocardial cushion morphogenesis cardiac right ventricle morphogenesis ventricular trabecula myocardium morphogenesis endocardial cushion fusion atrial septum primum morphogenesis protein phosphorylation cell cycle arrest transforming growth factor beta receptor signaling pathway SMAD protein import into nucleus cell-cell signaling axon guidance salivary gland morphogenesis heart development cell death cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation glial cell migration response to wounding embryo development cardioblast differentiation positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial cell migration negative regulation of alkaline phosphatase activity positive regulation of epithelial to mesenchymal transition positive regulation of pathway-restricted SMAD protein phosphorylation negative regulation of macrophage cytokine production positive regulation of phosphatidylinositol 3-kinase signaling cell growth cell migration signal transduction by protein phosphorylation hemopoiesis collagen fibril organization positive regulation of cell growth negative regulation of cell growth neutrophil chemotaxis hair follicle morphogenesis activation of protein kinase activity response to progesterone positive regulation of stress-activated MAPK cascade regulation of transforming growth factor beta2 production regulation of actin cytoskeleton organization positive regulation of cell adhesion mediated by integrin ascending aorta morphogenesis wound healing dopamine biosynthetic process odontogenesis response to drug catagen uterine wall breakdown positive regulation of neuron apoptotic process cell-cell junction organization positive regulation of integrin biosynthetic process positive regulation of ossification positive regulation of cell cycle positive regulation of heart contraction negative regulation of Ras protein signal transduction somatic stem cell division embryonic digestive tract development neuron fate commitment neuron development generation of neurons negative regulation of epithelial cell proliferation positive regulation of protein secretion negative regulation of immune response positive regulation of immune response positive regulation of cell division positive regulation of catagen positive regulation of cardioblast differentiation cardiac muscle cell proliferation cardiac epithelial to mesenchymal transition face morphogenesis pathway-restricted SMAD protein phosphorylation SMAD protein signal transduction ventricular septum morphogenesis atrial septum morphogenesis negative regulation of cartilage development pharyngeal arch artery morphogenesis positive regulation of activation-induced cell death of T cells positive regulation of extracellular matrix disassembly extrinsic apoptotic signaling pathway positive regulation of protein localization to nucleus regulation of apoptotic process involved in outflow tract morphogenesis regulation of complement-dependent cytotoxicity positive regulation of GTP binding negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of extrinsic apoptotic signaling pathway in absence of ligand skeletal system development blood vessel development outflow tract morphogenesis cardiac left ventricle morphogenesis extracellular matrix organization positive regulation of cell migration intracellular signal transduction growth regulation of cell proliferation regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process regulation of MAPK cascade response to estrogen negative regulation of keratinocyte differentiation embryonic neurocranium morphogenesis negative regulation of release of sequestered calcium ion into cytosol regulation of extracellular matrix organization
          It has to be done as per old AB suggested Products section.
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