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TGFB4 Polyclonal Antibody
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Product Details
BS-5778R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human TGFB4, amino acids 281-366.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Left-right determination factor 1 and 2 (Lefty1/2) belong to the TGF-beta superfamily of proteins and are responsible for determination of left-right positioning of visceral organs during embryogenesis. Lefty1 acts as a regulator of Lefty2 and NODAL as the lack of the former resulted in bilateral expression of nodal, lefty2 and Pitx2 (a homeobox gene normally expressed on the left side and blocks the signal for leftness). Lefty2 may play a role in endometrial bleeding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: endometrial bleeding associated factor; Endometrial bleeding-associated factor; Left-right determination factor 2; Left-right determination factor A; Left-right determination factor B; left-right determination, factor A; MGC46222; Protein lefty-2; Protein lefty-A; Protein lefty-B; TGF-beta-4; Transforming growth factor beta-4; unnamed protein product
Gene Aliases: 6030463A22Rik; AV214969; EBAF; Ebaf2; LEFTA; Leftb; LEFTY2; LEFTYA; PSEC0024; TGFB4
UniProt ID: (Human) O00292, (Mouse) P57785
Entrez Gene ID: (Human) 7044, (Rat) 289316, (Mouse) 320202
anterior/posterior axis specification
BMP signaling pathway
negative regulation of transcription from RNA polymerase II promoter
heart morphogenesis
determination of left/right symmetry
biological_process
negative regulation of cell proliferation
positive regulation of pathway-restricted SMAD protein phosphorylation
cell growth
response to retinoic acid
cell migration involved in gastrulation
regulation of apoptotic process
regulation of MAPK cascade
cell development
SMAD protein signal transduction
negative regulation of nodal receptor complex assembly
multicellular organism development
growth
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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