In direct ELISAs, approximately 5% cross-reactivity with recombinant human (rh) TGF-beta RII is observed and less than 1% cross-reactivity with recombinant mouse TGF-beta RI and rhTGF-beta RIII is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
A total of three members of the TGF beta family, TGF beta1, TGF beta2 and TGF beta3, have been identified in mammals. Each is synthesized as a latent precursor that is subsequently cleaved forming the 112 amino acid growth factor which becomes active upon dimerization. TGF betas mediate their activity by high affinity binding to the type II receptor (TGF beta RII) transmembrane protein with a cytoplasmic serine-threonine kinase domain. For signaling growth inhibition and early gene responses the type II receptor requires both its kinase activity and association with a TGF beta-binding protein, designated the type I receptor. Two independent groups have recently described the cloning and sequence analysis of genes encoding TGF beta type I receptor proteins designated ALK-5 (T betaR-1) and TSR-1, respectively.
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Protein Aliases: TbetaR-II; TGF-beta receptor II; TGF-beta receptor type II; TGF-beta receptor type-2; TGF-beta type II receptor; TGFBR2; TGFR-2; TGFR2; Transforming growth factor-beta receptor type II
Gene Aliases: 1110020H15Rik; AU042018; DNIIR; RIIDN; TbetaR-II; TbetaRII; TBR-II; Tgfbr2
UniProt ID: (Mouse) Q62312
Entrez Gene ID: (Mouse) 21813