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Immunogen sequence: HNTELLPIEL DTLVGKGRFA EVYKAKLKQN TSEQFETVAV KIFPYEEYAS WKTEKDIFSD INLKHENILQ FLTAEERKTE LGKQYWLITA FHAKGNLQEY LTRHVISWED LRKLGSSLAR GIAHLHSDHT PCGRPKMPIV HRDLKSSNIL VKNDLTCCLC DFGLSLRLDP TLSVDDLANS GQVGTARYMA PEVLESRMNL ENVESFKQTD VYSMALVLWE MTSRCNAVGE VKDYEPPFGS KVREHPCVES MKDNVLRDRG RPEIPSFWLN HQGIQMVCET LTECWDHDPE ARLTAQCVAE RFSELEHLDR LSG
Positive Samples: Mouse spleen, Rat lung; Cellular Location: Cell membrane, Single-pass type I membrane protein
Transforming Growth Factor, beta receptor 2 (AAT3, FAA3, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TGFR-2, TGFbeta-RII) is a member of the TGF-beta family of receptor Serine/Threonine kinases. It is involved in the regulation of cell proliferation. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). TGFBR2 encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. TGFBR2 also has a pseudogene on chromosome 14.
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Protein Aliases: tbetaR-II; tgf beta receptor 2; TGF-beta receptor II; TGF-beta receptor type II; TGF-beta receptor type-2; TGF-beta type II receptor; TGFbeta RII; TGFR-2; TGFR2; transforming growth factor beta receptor type II; transforming growth factor, beta receptor II; transforming growth factor, beta receptor IIT; transforming growth factor-b type II receptor; Transforming growth factor-beta receptor type II; transforming growth factor-beta type II receptor
Gene Aliases: 1110020H15Rik; AU042018; DNIIR; RIIDN; TbetaR-II; TbetaRII; TBR-II; TGF-beta 2; Tgfbr2; Tgfbr2T
Molecular Function: serine/threonine protein kinase receptor