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Invitrogen
TGIF Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-48328
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 208-237 amino acids from the Central region of human TGIF1.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
2.0 mg/mL
Amount
800 µg
Purification
Ammonium sulfate precipitation, Size-exclusion - Dialysis
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Predicted to react with chicken based on sequence homology.
Target Information
TGIF is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5'-TG-3'-interacting factor 1; TALE family homeobox; TALE homeobox TG-interacting factor; TG interacting factor 1; TGIF; transforming growth factor-beta-induced factor; unnamed protein product
Gene Aliases: HPE4; TGIF
UniProt ID: (Human) Q15583, (Mouse) P70284
Entrez Gene ID: (Human) 7050, (Mouse) 21815
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
co-SMAD binding
sequence-specific double-stranded DNA binding
JUN kinase binding
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
response to xenobiotic stimulus
negative regulation of gene expression
cellular response to growth factor stimulus
neural tube closure
determination of left/right symmetry
negative regulation of cell proliferation
dorsal/ventral pattern formation
regulation of gastrulation
nodal signaling pathway
positive regulation of neuron differentiation
positive regulation of fibroblast proliferation
negative regulation of retinoic acid receptor signaling pathway
retina development in camera-type eye
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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