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Product Details
PA5-48328
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 208-237 amino acids from the Central region of human TGIF1.
Conjugate
Form
Liquid
Concentration
2.0 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2633786
Product Specific Information
Predicted to react with chicken based on sequence homology.
Target Information
TGIF is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5'-TG-3'-interacting factor 1; Homeobox protein TGIF1; TALE family homeobox; TALE homeobox TG-interacting factor; TG interacting factor 1; TGFB-induced factor homeobox 1; transforming growth factor-beta-induced factor
Gene Aliases: AA959811; AI462167; HPE4; TGIF; TGIF1
UniProt ID: (Human) Q15583, (Mouse) P70284
Entrez Gene ID: (Human) 7050, (Mouse) 21815
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcription corepressor activity
protein binding
co-SMAD binding
DNA binding
chromatin binding
JUN kinase binding
homeodomain transcription factor
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
multicellular organism development
response to drug
cellular response to growth factor stimulus
neural tube closure
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
determination of left/right symmetry
negative regulation of cell proliferation
dorsal/ventral pattern formation
regulation of gastrulation
negative regulation of gene expression
nodal signaling pathway
positive regulation of neuron differentiation
positive regulation of fibroblast proliferation
negative regulation of retinoic acid receptor signaling pathway
retina development in camera-type eye
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