Synthetic peptide sequence: 7-34aa, LERCDLELETNGRDHHTADLCREKLVVR.
Reconstitution information: Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Transglutaminase (TGase) catalyzes the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal b-sandwich, catalytic core and two C-terminal b-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer's disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Ab peptide, b-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 184.108.40.206; C polypeptide; C polypeptide, protein-glutamine-gamma-glutamyltransferase; Protein-glutamine gamma-glutamyltransferase 2; protein-glutamine-gamma-glutamyltransferase; TG C; TG(C); TGase C; TGase H; TGase-2; TGC; TGM2; Tissue transglutaminase; tissue-type transglutaminase; transglutaminase 2, C polypeptide; Transglutaminase C; Transglutaminase H; Transglutaminase-2
Gene Aliases: G[a]h; TG(C); TG2; TGase2; TgaseII; TGC; TGM2; tTG; tTGas