Search
Invitrogen
TGM2 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-95256
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human TGM2 (7-34aa LERCDLELETNGRDHHTADLCREKLVVR).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: Rat Liver Tissue, Rat Ovary Tissue, HELA whole cell. IHC: mouse spleen tissue, rat spleen tissue, human intestinal cancer tissue, human mammary cancer tissue IHC-F: mouse spleen tissue, rat spleen tissue, human placenta tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
Transglutaminase (TGase) catalyses the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal b-sandwich, catalytic core and two C-terminal b-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer's disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Ab peptide, b-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C polypeptide; C polypeptide, protein-glutamine-gamma-glutamyltransferase; crosslinker; Erythrocyte transglutaminase; G alpha h; G(h); G-ALPHA-h; GNAH; Heart G alpha(h); hhG alpha(h); Isopeptidase TGM2; Protein G alpha(h); Protein G(h); Protein-glutamine deamidase TGM2; Protein-glutamine dopaminyltransferase TGM2; Protein-glutamine gamma-glutamyltransferase 2; Protein-glutamine histaminyltransferase TGM2; Protein-glutamine noradrenalinyltransferase TGM2; Protein-glutamine serotonyltransferase TGM2; protein-glutamine-gamma-glutamyltransferase; RP5-1054A22.2; TG C; TG(C); TG2; TGase 2; TGase C; TGase H; TGase II; TGase-2; TGase-H; TGC; Tissue transglutaminase; Tissue type transglutaminase; tissue-type transglutaminase; Transglutaminase 2 C polypeptide; transglutaminase 2, C polypeptide; Transglutaminase C; Transglutaminase H; Transglutaminase II; Transglutaminase-2; tTG; tTgase; unnamed protein product
Gene Aliases: G(h); G[a]h; hTG2; TG(C); TG2; TGase2; TgaseII; TGC; TGM2; tTG; tTGas
UniProt ID: (Human) P21980, (Rat) Q9WVJ6, (Mouse) P21981
Entrez Gene ID: (Human) 7052, (Rat) 56083, (Mouse) 21817
nucleotide binding
protein-glutamine gamma-glutamyltransferase activity
calcium ion binding
protein binding
GTP binding
peptidase activity
transferase activity
transferase activity, transferring acyl groups
hydrolase activity
metal ion binding
protein-glutamine glutaminase activity
peptide serotonyltransferase activity
histone serotonyltransferase activity
peptide dopaminyltransferase activity
histone dopaminyltransferase activity
peptide noradrenalinyltransferase activity
peptide histaminyltransferase activity
enzyme binding
protein domain specific binding
transaminase activity
transferase
chromatin remodeling
proteolysis
phospholipase C-activating G-protein coupled receptor signaling pathway
gene expression
dopamine secretion
peptide cross-linking
protein deamination
negative regulation of endoplasmic reticulum calcium ion concentration
regulation of apoptotic process
positive regulation of apoptotic process
apoptotic cell clearance
positive regulation of GTPase activity
positive regulation of cell adhesion
positive regulation of neurogenesis
positive regulation of small GTPase mediated signal transduction
protein homooligomerization
positive regulation of mitochondrial calcium ion concentration
bone development
branching involved in salivary gland morphogenesis
salivary gland cavitation
cellular response to cocaine
cellular response to dopamine
positive regulation of sprouting angiogenesis
cellular response to serotonin
regulation of apoptotic cell clearance
blood vessel remodeling
isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of smooth muscle cell proliferation
positive regulation of inflammatory response
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
G-protein coupled receptor signaling pathway
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support