Immunogen sequence: VNLSVFCDHNY TVEDTMHQRK RIHQLEQQVE KLRKKLKTAQ QRCRRQERQL EKLKEVVHFQ KEKDDVSERG YVILPNDYF
Highest antigen sequence identity to the following orthologs - mouse 95%, rat 94%.
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 4833431A01Rik; nuclear proapoptotic factor; THAP domain containing, apoptosis associated protein 1; THAP domain protein 1; THAP domain-containing protein 1
Gene Aliases: DYT6; THAP1
UniProt ID: (Human) Q9NVV9
Entrez Gene ID: (Human) 55145
Molecular Function: zinc finger transcription factor