|Immunohistochemistry (Paraffin) (IHC (P))||10 µg/ml|
|Western Blot (WB)||0.05-0.1 µg/ml|
|Tested Species reactivity||Human, Non-human primate, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (123 KATGKLIAQGRHTKHLGN 140) of THEM2 protein.|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
THEM2 is a 140 amino acid enzyme with hydrolase activity belonging to the thioesterase superfamily and UPF0152 (paal) family. Human THEM2 contains a hotdog-fold and forms a back-to-back tetramer with the active site located in an inter-subunit cleft. The biological function of THEM2 is yet unknown. The role of THEM2 and Pax3 (paired box gene 3) as PC-TP-interacting proteins has been determined by using yeast two-hybrid screening. Small interference RNA silencing data suggest that the gene encoding THEM2 is essential for the cell sustained proliferation. THEM2 is highly expressed in kidney, and moderately in liver, brain, large intestine, and small intestine. THEM2 is co-localized with microtubules and is implicated in the genetic background of developmental dyslexia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Acyl-CoA thioesterase 13; Acyl-coenzyme A thioesterase 13; HT012; hypothalamus protein HT012; PNAS-27; THEM2; Thioesterase superfamily member 2
Gene Aliases: ACOT13; HT012; PNAS-27; THEM2
UniProt ID: (Human) Q9NPJ3
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