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Proteintech
THEM4 Polyclonal Antibody
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Product Details
14692-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
THEM4 Fusion Protein Ag6244 (1-240 aa encoded by BC065277)
Conjugate
Form
Liquid
Concentration
0.63 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MLRSCAARL RTLGALCRPP VGRRLPGSEP RPELRSFSSE EVILKDCSVP NPSWNKDLRL LFDQFMKKCE DGSWKRLPSY KRTPTEWIQD FKTHFLDPKL MKEEQMSQAQ LFTRSFDDGL GFEYVMFYND IEKRMVCLFQ GGPYLEGPPG FIHGGAIATM IDATVGMCAM MAGGIVMTAN LNINYKRPIP LCSVVMINSQ LDKVEGRKFF VSCNVQSVDE KTLYSEATSL FIKLNPAKSL T (1-240 aa encoded by BC065277)
Target Information
THEM4, also known as CTMP, binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells. Hypermethylation of the THEM4 promoter and transcriptional downregulation of the gene has been reported in multiple glioblastomas, suggesting that epigenetic regulation of THEM4 may play a role in the progression of this cancer. Bioinformatic analysis, confirmed by in vitro testing, indicates that THEM4 is a broad-range, high activity acyl-CoA thioesterase. Recent reports have also indicated that TMEM4 is a mitochondrial protein whose overexpression is associated with an increase in mitochondrial membrane depolarization and caspase-3 and PARP cleavage, suggesting that THEM4 is involved in the apoptotic program.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acyl-CoA thioesterase THEM4; Acyl-coenzyme A thioesterase THEM4; C-terminal modulator protein; Carboxyl-terminal modulator protein; Thioesterase superfamily member 4
Gene Aliases: 2700077M13Rik; 4921507I02Rik; CTMP; RGD1304723; THEM4
UniProt ID: (Human) Q5T1C6, (Rat) Q566R0, (Mouse) Q3UUI3
Entrez Gene ID: (Human) 117145, (Rat) 361992, (Mouse) 75778
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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