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Invitrogen
THOC5 Polyclonal Antibody
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FIGURE: 1 / 3
THOC5 Antibody (PA5-119821) in IHC (P)
Immunohistochemistry (Paraffin) analysis of paraffin-embedded human ovarian tumor tissue using THOC5 Polyclonal Antibody (Product # PA5-119821). The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the THOC5 antibody at a dilu... View More
Product Details
PA5-119821
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein within human THOC5 aa 1-200
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: NIH/3T3 cell lysate, PC-12 cell lysate, Hela cell lysate, HepG2 cell lysate, human ovarian tumor tissue, mouse brain tissue.
Subcellular Location: Nucleus, Cytoplasm.
Target Information
Component the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction beteen KSHV ORF57 protein and THOC4. UAP56 functions as a bridge between THOC4 and the THO complex. THOC5 in conjunction with THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA. May be involved in the differentiation of granulocytes and adipocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FMIP; Fms interacting protein; Fms-interacting protein; fSAP79; Functional spliceosome-associated protein 79; hTREX90; NF2/meningioma region protein pK1.3; Placental protein 39.2; PP39.2; serum/glucocorticoid regulated kinase 2; THO complex subunit 5; THO complex subunit 5 homolog
Gene Aliases: 1700060C24Rik; A430085L24Rik; C22orf19; Fmip; fSAP79; KIAA0983; PK1.3; Sgk2; THOC5
UniProt ID: (Human) Q13769, (Mouse) Q8BKT7, (Rat) Q68FX7
Entrez Gene ID: (Human) 8563, (Mouse) 107829, (Rat) 360972
termination of RNA polymerase II transcription
RNA export from nucleus
mRNA export from nucleus
RNA splicing
monocyte differentiation
mRNA 3'-end processing
positive regulation of DNA-templated transcription, elongation
viral mRNA export from host cell nucleus
primitive hemopoiesis
negative regulation of DNA damage checkpoint
cell morphogenesis
blastocyst development
mRNA processing
transport
regulation of gene expression
regulation of mRNA export from nucleus
stem cell division
cell differentiation
negative regulation of macrophage differentiation
mRNA transport
regulation of stem cell division
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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