PA5-31594 targets THOC7 in IF and WB applications and shows reactivity with Human and mouse samples.
The PA5-31594 immunogen is recombinant protein fragment corresponding to a region within amino acids 6 and 193 of Human THOC7.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. UAP56 functions as a bridge between THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and THOC4.
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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: fSAP24; Functional spliceosome-associated protein 24; hTREX30; Ngg1 interacting factor 3 like 1 binding protein 1; Ngg1-interacting factor 3-like protein 1-binding protein 1; NIF3L1-binding protein 1; NIF3L1BP1; THO complex 7 homolog; THO complex subunit 7 homolog
Gene Aliases: fSAP24; hTREX30; NIF3L1BP1; THOC7