Product References
Angiotensin type 2 receptor activation promotes browning of white adipose tissue and brown adipogenesis.
Signal transduction and targeted therapy
Than A,Xu S,Li R,Leow MK,Sun L,Chen P
PA1-211A was used in Western Blotting to reveal the browning and brown adipogenic effects of angiotensin type 2 receptor and suggests a potential therapeutic target to combat obesity and related metabolic disorders.
Tue Feb 02 00:00:00 EST 2021
Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function.
Nature medicine
Yu G,Tzouvelekis A,Wang R,Herazo-Maya JD,Ibarra GH,Srivastava A,de Castro JPW,DeIuliis G,Ahangari F,Woolard T,Aurelien N,Arrojo E Drigo R,Gan Y,Graham M,Liu X,Homer RJ,Scanlan TS,Mannam P,Lee PJ,Herzog EL,Bianco AC,Kaminski N
Published figure using THRA polyclonal antibody (Product # PA1-211A) in Immunomicroscopy
Mon Jan 01 00:00:00 EST 2018
Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function.
Nature medicine
Yu G,Tzouvelekis A,Wang R,Herazo-Maya JD,Ibarra GH,Srivastava A,de Castro JPW,DeIuliis G,Ahangari F,Woolard T,Aurelien N,Arrojo E Drigo R,Gan Y,Graham M,Liu X,Homer RJ,Scanlan TS,Mannam P,Lee PJ,Herzog EL,Bianco AC,Kaminski N
Published figure using THRA polyclonal antibody (Product # PA1-211A) in Immunomicroscopy
Mon Jan 01 00:00:00 EST 2018
Effect of neonatal hypothyroidism on prepubertal mouse testis in relation to thyroid hormone receptor alpha 1 (THRα1).
General and comparative endocrinology
Sarkar D,Singh SK
PA1211A was used in immunohistochemistry - paraffin section and western blot to assess the effect of neonatal hypothyroidism on prepubertal Parkes strain mice testis relative to thyroid hormone receptor alpha 1
Fri Sep 15 00:00:00 EDT 2017
Changes in Hepatic TRβ Protein Expression, Lipogenic Gene Expression, and Long-Chain Acylcarnitine Levels During Chronic Hyperthyroidism and Triiodothyronine Withdrawal in a Mouse Model.
Thyroid : official journal of the American Thyroid Association
Ohba K,Sinha RA,Singh BK,Iannucci LF,Zhou J,Kovalik JP,Liao XH,Refetoff S,Sng JCG,Leow MK,Yen PM
PA1-211A was used in Western Blotting to determine the possible mechanism for hepatic gene desensitisation following multiple triiodothyronine injections, and to study the incomplete recovery of hepatic target gene transcription and their effects on metabolism.
Thu Jun 01 00:00:00 EDT 2017
Ligand Independent and Subtype-Selective Actions of Thyroid Hormone Receptors in Human Adipose Derived Stem Cells.
PloS one
Cvoro A,Bajic A,Zhang A,Simon M,Golic I,Sieglaff DH,Maletic-Savatic M,Korac A,Webb P
PA1211A was used in immunocytochemistry and western blot to define specific role for thyroid hormone receptor alpha and beta
Mon May 29 00:00:00 EDT 2017
Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium.
Autophagy
Yao J,Jia L,Khan N,Lin C,Mitter SK,Boulton ME,Dunaief JL,Klionsky DJ,Guan JL,Thompson DA,Zacks DN
PA1-211A was used in western blot to assess the relationship between reduced autophagy and age-related degeneration of the retinal pigment epithelium.
Fri Apr 22 00:00:00 EDT 2016
MuRF1 mono-ubiquitinates TRα to inhibit T3-induced cardiac hypertrophy in vivo.
Journal of molecular endocrinology
Wadosky KM,Berthiaume JM,Tang W,Zungu M,Portman MA,Gerdes AM,Willis MS
PA1-211A was used in western blot to assess inhibition of T3-induced cardiac hypertrophy in vivo by MuRF1 mono-ubiquitinating TR-alpha
Fri Apr 01 00:00:00 EDT 2016
Hypothyroidism advances mammary involution in lactating rats through inhibition of PRL signaling and induction of LIF/STAT3 mRNAs.
Molecular and cellular endocrinology
Campo Verde Arboccó F,Sasso CV,Actis EA,Carón RW,Hapon MB,Jahn GA
PA1-211A was used in western blot to examine the effects of hypothyroidism on late lactation
Tue Jan 05 00:00:00 EST 2016
PHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban.
The Journal of clinical investigation
Xie L,Pi X,Townley-Tilson WH,Li N,Wehrens XH,Entman ML,Taffet GE,Mishra A,Peng J,Schisler JC,Meissner G,Patterson C
PA1-211A was used in western blot to investigate how PHD2 and PHD3 modulate contractile function.
Wed Jul 01 00:00:00 EDT 2015
Luteal expression of thyroid hormone receptors during gestation and postpartum in the rat.
Thyroid : official journal of the American Thyroid Association
Navas PB,Redondo AL,Cuello-Carrión FD,Roig LM,Valdez SR,Jahn GA,Hapon MB
PA1-211A was used in western blot to study the gestational and post-partum expression of thyroid hormone recptors in rat corpora lutea
Sun Jun 01 00:00:00 EDT 2014
Differential regulation of steroidogenic enzyme genes by TRα signaling in testicular Leydig cells.
Molecular endocrinology (Baltimore, Md.)
Park E,Kim Y,Lee HJ,Lee K
PA1-211A was used in Immunohistochemistry to suggest a role of TRα/T3 in testicular steroidogenesis and may provide molecular mechanisms for the differential regulation of steroidogenic enzyme genes by thyroid hormone.
Sun Jun 01 00:00:00 EDT 2014
Inhibition of thyroid hormone receptor α1 impairs post-ischemic cardiac performance after myocardial infarction in mice.
Molecular and cellular biochemistry
Mourouzis I,Kostakou E,Galanopoulos G,Mantzouratou P,Pantos C
PA1-211A was used in western blot to study the deleterious effect of pharmacological inhibition of thyroid hormone receptor alpha1 on post-ischemic cardiac function in a murine model of myocardial infarction
Mon Jul 01 00:00:00 EDT 2013
The trifunctional protein mediates thyroid hormone receptor-dependent stimulation of mitochondria metabolism.
Molecular endocrinology (Baltimore, Md.)
Chocron ES,Sayre NL,Holstein D,Saelim N,Ibdah JA,Dong LQ,Zhu X,Cheng SY,Lechleiter JD
PA1-211A was used in western blot to study the role of mitochondrial trifunctional protein in thyroid hormone receptor-dependent stimulation of mitochondrial metabolism
Sun Jul 01 00:00:00 EDT 2012
Identical gene regulation patterns of T3 and selective thyroid hormone receptor modulator GC-1.
Endocrinology
Yuan C,Lin JZ,Sieglaff DH,Ayers SD,Denoto-Reynolds F,Baxter JD,Webb P
PA1-211A was used in western blot to investigate the pattern of GC-1 and T3-mediated gene expression in vivo and in vitro
Sun Jan 01 00:00:00 EST 2012
Cardiac PPARalpha Protein Expression is Constant as Alternate Nuclear Receptors and PGC-1 Coordinately Increase During the Postnatal Metabolic Transition.
PPAR research
Buroker NE,Ning XH,Portman M
PA1-211A was used in western blot to investigate the effect of postnatal metabolic transition on the expression of cardiac PPARalpha, alternate nuclear receptors and PGC-1
Thu Jul 14 00:00:00 EDT 2011
Thyroid hormone can favorably remodel the diabetic myocardium after acute myocardial infarction.
Molecular and cellular biochemistry
Kalofoutis C,Mourouzis I,Galanopoulos G,Dimopoulos A,Perimenis P,Spanou D,Cokkinos DV,Singh J,Pantos C
PA1-211A was used in western blot to investigate the effect of thyroid hormone on remodelling the diabetic myocardium
Wed Dec 01 00:00:00 EST 2010
Up-regulation of type 2 iodothyronine deiodinase in dilated cardiomyopathy.
Cardiovascular research
Wang YY,Morimoto S,Du CK,Lu QW,Zhan DY,Tsutsumi T,Ide T,Miwa Y,Takahashi-Yanaga F,Sasaguri T
PA1-211A was used in western blot to investigate the possible mechanism of the pathogenesis of DCM caused by hyperthyroidism using a konck-in mouse model
Wed Sep 01 00:00:00 EDT 2010
Thyroid hormone receptor alpha1 downregulation in postischemic heart failure progression: the potential role of tissue hypothyroidism.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
Pantos C,Mourouzis I,Galanopoulos G,Gavra M,Perimenis P,Spanou D,Cokkinos DV
PA1-211A was used in western blot to investigate the downregulation of thyroid hormone receptor alpha1 in postischemic heart failure progression
Wed Sep 01 00:00:00 EDT 2010
Aging impairs myocardial fatty acid and ketone oxidation and modifies cardiac functional and metabolic responses to insulin in mice.
American journal of physiology. Heart and circulatory physiology
Hyyti OM,Ledee D,Ning XH,Ge M,Portman MA
PA1-211A was used in western blot to investigate the effect of aging on myocardial fatty acid, ketone oxidation, and insulin sensitivity in mice
Wed Sep 01 00:00:00 EDT 2010
TNF-alpha administration in neonatal cardiomyocytes is associated with differential expression of thyroid hormone receptors: a response prevented by T3.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
Pantos C,Xinaris C,Mourouzis I,Kokkinos AD,Cokkinos DV
PA1-211A was used in western blot to investigate the effect of tumor necrosis factor alpha administration on thyroid hormone receptors in neonatal cardiomyocytes
Wed Oct 01 00:00:00 EDT 2008
Inhibition of apoptotic potency by ligand stimulated thyroid hormone receptors located in mitochondria.
Apoptosis : an international journal on programmed cell death
Saelim N,Holstein D,Chocron ES,Camacho P,Lechleiter JD
PA1-211A was used in western blot to investigate the role of thyroid hormone receptors in apoptosis
Mon Oct 01 00:00:00 EDT 2007
De-phosphorylation of TRalpha-1 by p44/42 MAPK inhibition enhances T(3)-mediated GLUT5 gene expression in the intestinal cell line Caco-2 cells.
Biochemical and biophysical research communications
Mochizuki K,Sakaguchi N,Takabe S,Goda T
PA1-211A was used in EMSA to investigate the effect of U0126 on thyroid receptor alpha-1 phosphorylation status and GLUT5 expression in Caco-2 cells
Fri Aug 10 00:00:00 EDT 2007
Thyroid hormone attenuates cardiac remodeling and improves hemodynamics early after acute myocardial infarction in rats.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
Pantos C,Mourouzis I,Markakis K,Dimopoulos A,Xinaris C,Kokkinos AD,Panagiotou M,Cokkinos DV
PA1-211A was used in western blot to investigate the role of thyroid hormone on cardiac remodeling and myocardial performance in rat
Wed Aug 01 00:00:00 EDT 2007
Time-dependent changes in the expression of thyroid hormone receptor alpha 1 in the myocardium after acute myocardial infarction: possible implications in cardiac remodelling.
European journal of endocrinology
Pantos C,Mourouzis I,Xinaris C,Kokkinos AD,Markakis K,Dimopoulos A,Panagiotou M,Saranteas T,Kostopanagiotou G,Cokkinos DV
PA1-211A was used in western blot to investigate the expression of thyroid hormone receptor alpha 1 in the myocardium after acute myocardial infarction
Sun Apr 01 00:00:00 EDT 2007
The dominant negative thyroid hormone receptor beta-mutant {Delta}337T alters PPAR{alpha} signaling in heart.
American journal of physiology. Endocrinology and metabolism
Buroker NE,Young ME,Wei C,Serikawa K,Ge M,Ning XH,Portman MA
PA1-211A was used in western blot to investigate the effect of thyroid hormone receptor beta-mutant for PPAR alpha signaling in heart
Thu Feb 01 00:00:00 EST 2007
Thyroid hormone receptor isoforms localize to cardiac mitochondrial matrix with potential for binding to receptor elements on mtDNA.
Mitochondrion
Morrish F,Buroker NE,Ge M,Ning XH,Lopez-Guisa J,Hockenbery D,Portman MA
PA1-211A was used in western blot to study teh localization of thyroid hormone receptor isoforms in cardiac mitochondrial matrix
Thu Jun 01 00:00:00 EDT 2006
Thyroid hormone-mediated negative transcriptional regulation of Necdin expression.
Journal of molecular endocrinology
Nygård M,Becker N,Demeneix B,Pettersson K,Bondesson M
PA1-211A was used in western blot to investigate the effect of thyroid hormone on Necdin expression
Thu Jun 01 00:00:00 EDT 2006
Nuclear localization of protein kinase C-alpha induces thyroid hormone receptor-alpha1 expression in the cardiomyocyte.
American journal of physiology. Heart and circulatory physiology
Kenessey A,Sullivan EA,Ojamaa K
PA1-211A was used in western blot to study the role of protein kinase C signaling in regulating the function of thyroid hormone receptor in the cardiomyocyte
Sun Jan 01 00:00:00 EST 2006
Thyroid hormone receptors alpha1 and beta1 are downregulated in the post-infarcted rat heart: consequences on the response to ischaemia-reperfusion.
Basic research in cardiology
Pantos C,Mourouzis I,Saranteas T,Paizis I,Xinaris C,Malliopoulou V,Cokkinos DV
PA1-211A was used in western blot to investigate the function of thyroid hormone signaling in the response of heart to ischaemia-reperfusion after myocardial infarction
Thu Sep 01 00:00:00 EDT 2005
Ligand-mediated decrease of thyroid hormone receptor-alpha1 in cardiomyocytes by proteosome-dependent degradation and altered mRNA stability.
American journal of physiology. Heart and circulatory physiology
Kenessey A,Ojamaa K
PA1-211A was used in western blot to study how T3 regulates the degradation of TR
Tue Feb 01 00:00:00 EST 2005
Multiple messenger ribonucleic acid variants regulate cell-specific expression of human thyroid hormone receptor beta1.
Molecular endocrinology (Baltimore, Md.)
Frankton S,Harvey CB,Gleason LM,Fadel A,Williams GR
PA1-211A was used in immunocytochemistry to demonstrate the function of human thyroid hormone receptor beta1 5-UTR mRNAs.
Thu Jul 01 00:00:00 EDT 2004
Thyroid-hormone-dependent negative regulation of thyrotropin beta gene by thyroid hormone receptors: study with a new experimental system using CV1 cells.
The Biochemical journal
Nakano K,Matsushita A,Sasaki S,Misawa H,Nishiyama K,Kashiwabara Y,Nakamura H
PA1-211A was used in western blot to investigate the role of thyroid hormone receptors in regulation of thyrotropin beta gene
Mon Mar 01 00:00:00 EST 2004
TR expression and function in human bone marrow stromal and osteoblast-like cells.
The Journal of clinical endocrinology and metabolism
Siddiqi A,Parsons MP,Lewis JL,Monson JP,Williams GR,Burrin JM
PA1-211A was used in immunocytochemistry to investigate the functions of TR in human bone marrow stromal and osteoblast-like cells.
Fri Feb 01 00:00:00 EST 2002
Thyroid status affects number and localization of thyroid hormone receptor expressing mast cells in bone marrow.
Bone
Siebler T,Robson H,Bromley M,Stevens DA,Shalet SM,Williams GR
PA1-211A was used in immunohistochemistry to investigate the association between thyroid status and thyroid hormone receptor expressing mast cells
Tue Jan 01 00:00:00 EST 2002
Nucleocytoplasmic shuttling of the thyroid hormone receptor alpha.
Molecular endocrinology (Baltimore, Md.)
Bunn CF,Neidig JA,Freidinger KE,Stankiewicz TA,Weaver BS,McGrew J,Allison LA
PA1-211A was used in immunocytochemistry to study the nucleocytoplasmic translocation of the thyroid hormone receptor alpha.
Sun Apr 01 00:00:00 EST 2001
Expression of thyroid receptor isoforms in the human fetal central nervous system and the effects of intrauterine growth restriction.
Clinical endocrinology
Kilby MD,Gittoes N,McCabe C,Verhaeg J,Franklyn JA
PA1-211A was used in immunocytochemistry to investigate the effects of severe IUGR on the expression of TR isoforms in the human fetal central nervous system
Sun Oct 01 00:00:00 EDT 2000
Thyroid hormone inhibits the human prolactin gene promoter by interfering with activating protein-1 and estrogen stimulations.
Molecular endocrinology (Baltimore, Md.)
Pernasetti F,Caccavelli L,Van de Weerdt C,Martial JA,Muller M
PA1-211A was used in EMSA assay to investigate the role of thyroid hormone on hPRL gene transcription
Sun Jun 01 00:00:00 EDT 1997