Invitrogen

THRA Polyclonal Antibody

Tech Support

Datasheet

Protocols

Questions & Answers

Tech Support

Product Image Gallery

THRA Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of Thyroid Hormone Receptor alpha-1 (green) showing staining in the nucleus and cytoplasm of U251 cells (right) compared to a negative control without primary antibody (left). Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with a Thyroid Hormone Receptor alpha-1 polyclonal antibody (Product # PA1-211A) in 3% BSA-PBS at a dilution of 1:100 and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight-conjugated secondary antibody in PBS at room temperature in the dark. F-actin (red) was stained with a fluorescent red phalloidin and nuclei (blue) were stained with Hoechst or DAPI. Images were taken at a magnification of 60x.

THRA Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry analysis of Thyroid Hormone Receptor alpha-1 showing staining in the cytoplasm and weak staining in the nucleus of paraffin-embedded mouse thyroid tissue (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at room temperature, washed with ddH2O and PBS, and then probed with a Thyroid Hormone Receptor alpha-1 Rabbit Polyclonal Antibody (Product # PA1-211A) diluted in 3% BSA-PBS at a dilution of 1:20 for 1 hour at 37ºC in a humidified chamber. Tissues were washed extensively in PBST and detection was performed using an HRP-conjugated secondary antibody followed by colorimetric detection using a DAB kit. Tissues were counterstained with hematoxylin and dehydrated with ethanol and xylene to prep for mounting.

THRA Antibody in Western Blot (WB) — Western blot analysis of Thyroid Hormone Receptor alpha-1 was performed by loading 25 µg of A431 (lane 1), rat thyroid (lane 2) and mouse thyroid (lane 3) cell lysates onto an SDS polyacrylamide gel. Proteins were transferred to a PVDF membrane and blocked at 4°C overnight. The membrane was probed with a Thyroid Hormone Receptor alpha-1 polyclonal antibody (Product # PA1-211A) at a dilution of 1:500 overnight at 4°C, washed in TBST, and probed with an HRP-conjugated secondary antibody for 1 hr at room temperature in the dark. Chemiluminescent detection was performed using Pierce ECL Plus Western Blotting Substrate (Product # 32132). Results show a band at ~48 kDa.

THRA Antibody in Immunomicroscopy (IM) — Figure 5 Anti-fibrotic effects of TH are mediated through PPARGC1A. ( a )Quantitative RT-PCR analysis for Ppargc1a mRNA levels in theindicated treatment groups (means + SEM),* P < 0.001. ( b ) Lunghydroxyproline content, and quantitative RT-PCR analysis of collagen type 1,alpha 1 ( Col1a1 ) (c) and type 3, alpha 1( Col3a1 ) (d) mRNA levels in Ppargc1a -deficient( Ppargc1a -/- ) mice or wild-typelittermates ( Ppargc1a +/+ ) treated with aerosolized T3 followingintratracheal challenge with bleomycin or equivalent volume of normal saline.Data presented are from one of two independent experiments with similar resultsand are expressed as mean hydroxyproline content per lung (mug/gr lung)set + SEM, * P <0.001. ( e ) Masson's Trichrome staining of representativelung sections ( n = 3) from each group of miceindicated. Scale bars, 50 mum. ( f ) Immunofluorescenceanalysis for Mito-Tracker (red cationic dye that stains active mitochondria) andPPARGC1A (green) in A549 cells after pre-incubation with dronedarone for 24 hror saline and treatment with or without T3. Colocalization of PPARGC1A withMito-Tracker is denoted in yellow. Boxed regions are shown enlarged at upperright panels. Scale bars, 50mum, insets 10 mum. ( g )Immunoblot of PPARGC1A in A549 cell lysates from cells treated as described for f ( n = 2/group). Immunoblot gels werecropped and uncropped images of the immunoblot gels are in Supplementary Fig 4 .( h ) Immunofluorescence (left and upper right) and quantitativeanalysis (

Product Details

PA1-211A

Applications	Tested Dilution	Publications
Western Blot (WB)	1:200	View 25 publications 25 publications
Immunohistochemistry (IHC)	-	View 3 publications 3 publications
Immunohistochemistry (Paraffin) (IHC (P))	1:20-1:100	View 1 publication 1 publication
Immunocytochemistry (ICC/IF)	1:10-1:200	View 5 publications 5 publications
Immunomicroscopy (IM)	-	View 1 publication 1 publication
Gel Shift (GS)	1:10	View 2 publications 2 publications
Miscellaneous PubMed (Misc)	-	View 1 publication 1 publication

Product Specifications
Species Reactivity	Chicken, Human, Mouse, Rat
Published species	Human, Mouse, Non-human primate, Rat, Sheep, Xenopus
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Synthetic Peptide: E(403) V F E D Q E V(410)
Conjugate	Unconjugated
Form	Liquid
Concentration	Conc. Not Determined
Storage buffer	whole serum diluted in PBS
Contains	0.05% sodium azide
Storage conditions	-20° C, Avoid Freeze/Thaw Cycles
RRID	AB_325811

Product Specific Information

PA1-211A detects thyroid receptor (TR) from human, mouse, rat and chicken samples. This antibody does not detect TRv alpha -2 or TR beta-1.

PA1-211A has been successfully used in Western blot, IHC-P, ICC/IF and gel shift procedures. By Western blot, this antibody detects a ~48 kDa protein representing recombinant human TR alpha-1 expressed in E. coli. Gel shift experiments show that this product reacts with TR alpha-1 homodimers and TR alpha-1/retinoic X receptor (RXR) heterodimers.

PA1-211A immunizing peptide corresponds to amino acid residues 403-410 from human TR alpha-1. This sequence is completely conserved between human and rat TR alpha-1.

Target Information

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Angiotensin type 2 receptor activation promotes browning of white adipose tissue and brown adipogenesis.

Signal transduction and targeted therapy

Than A,Xu S,Li R,Leow MK,Sun L,Chen P

PA1-211A was used in Western Blotting to reveal the browning and brown adipogenic effects of angiotensin type 2 receptor and suggests a potential therapeutic target to combat obesity and related metabolic disorders.

Tue Feb 02 00:00:00 EST 2021

Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function.

Nature medicine

Yu G,Tzouvelekis A,Wang R,Herazo-Maya JD,Ibarra GH,Srivastava A,de Castro JPW,DeIuliis G,Ahangari F,Woolard T,Aurelien N,Arrojo E Drigo R,Gan Y,Graham M,Liu X,Homer RJ,Scanlan TS,Mannam P,Lee PJ,Herzog EL,Bianco AC,Kaminski N

Published figure using THRA polyclonal antibody (Product # PA1-211A) in Immunomicroscopy

Mon Jan 01 00:00:00 EST 2018

Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function.

Nature medicine

Published figure using THRA polyclonal antibody (Product # PA1-211A) in Immunomicroscopy

Mon Jan 01 00:00:00 EST 2018

Effect of neonatal hypothyroidism on prepubertal mouse testis in relation to thyroid hormone receptor alpha 1 (THRα1).

General and comparative endocrinology

Sarkar D,Singh SK

PA1211A was used in immunohistochemistry - paraffin section and western blot to assess the effect of neonatal hypothyroidism on prepubertal Parkes strain mice testis relative to thyroid hormone receptor alpha 1

Fri Sep 15 00:00:00 EDT 2017

Changes in Hepatic TRβ Protein Expression, Lipogenic Gene Expression, and Long-Chain Acylcarnitine Levels During Chronic Hyperthyroidism and Triiodothyronine Withdrawal in a Mouse Model.

Thyroid : official journal of the American Thyroid Association

Ohba K,Sinha RA,Singh BK,Iannucci LF,Zhou J,Kovalik JP,Liao XH,Refetoff S,Sng JCG,Leow MK,Yen PM

PA1-211A was used in Western Blotting to determine the possible mechanism for hepatic gene desensitisation following multiple triiodothyronine injections, and to study the incomplete recovery of hepatic target gene transcription and their effects on metabolism.

Thu Jun 01 00:00:00 EDT 2017

Ligand Independent and Subtype-Selective Actions of Thyroid Hormone Receptors in Human Adipose Derived Stem Cells.

PloS one

Cvoro A,Bajic A,Zhang A,Simon M,Golic I,Sieglaff DH,Maletic-Savatic M,Korac A,Webb P

PA1211A was used in immunocytochemistry and western blot to define specific role for thyroid hormone receptor alpha and beta

Mon May 29 00:00:00 EDT 2017

Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium.

Autophagy

Yao J,Jia L,Khan N,Lin C,Mitter SK,Boulton ME,Dunaief JL,Klionsky DJ,Guan JL,Thompson DA,Zacks DN

PA1-211A was used in western blot to assess the relationship between reduced autophagy and age-related degeneration of the retinal pigment epithelium.

Fri Apr 22 00:00:00 EDT 2016

MuRF1 mono-ubiquitinates TRα to inhibit T3-induced cardiac hypertrophy in vivo.

Journal of molecular endocrinology

Wadosky KM,Berthiaume JM,Tang W,Zungu M,Portman MA,Gerdes AM,Willis MS

PA1-211A was used in western blot to assess inhibition of T3-induced cardiac hypertrophy in vivo by MuRF1 mono-ubiquitinating TR-alpha

Fri Apr 01 00:00:00 EDT 2016

Hypothyroidism advances mammary involution in lactating rats through inhibition of PRL signaling and induction of LIF/STAT3 mRNAs.

Molecular and cellular endocrinology

Campo Verde Arboccó F,Sasso CV,Actis EA,Carón RW,Hapon MB,Jahn GA

PA1-211A was used in western blot to examine the effects of hypothyroidism on late lactation

Tue Jan 05 00:00:00 EST 2016

PHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban.

The Journal of clinical investigation

Xie L,Pi X,Townley-Tilson WH,Li N,Wehrens XH,Entman ML,Taffet GE,Mishra A,Peng J,Schisler JC,Meissner G,Patterson C

PA1-211A was used in western blot to investigate how PHD2 and PHD3 modulate contractile function.

Wed Jul 01 00:00:00 EDT 2015

Luteal expression of thyroid hormone receptors during gestation and postpartum in the rat.

Thyroid : official journal of the American Thyroid Association

Navas PB,Redondo AL,Cuello-Carrión FD,Roig LM,Valdez SR,Jahn GA,Hapon MB

PA1-211A was used in western blot to study the gestational and post-partum expression of thyroid hormone recptors in rat corpora lutea

Sun Jun 01 00:00:00 EDT 2014

Differential regulation of steroidogenic enzyme genes by TRα signaling in testicular Leydig cells.

Molecular endocrinology (Baltimore, Md.)

Park E,Kim Y,Lee HJ,Lee K

PA1-211A was used in Immunohistochemistry to suggest a role of TRα/T3 in testicular steroidogenesis and may provide molecular mechanisms for the differential regulation of steroidogenic enzyme genes by thyroid hormone.

Sun Jun 01 00:00:00 EDT 2014

Inhibition of thyroid hormone receptor α1 impairs post-ischemic cardiac performance after myocardial infarction in mice.

Molecular and cellular biochemistry

Mourouzis I,Kostakou E,Galanopoulos G,Mantzouratou P,Pantos C

PA1-211A was used in western blot to study the deleterious effect of pharmacological inhibition of thyroid hormone receptor alpha1 on post-ischemic cardiac function in a murine model of myocardial infarction

Mon Jul 01 00:00:00 EDT 2013

The trifunctional protein mediates thyroid hormone receptor-dependent stimulation of mitochondria metabolism.

Molecular endocrinology (Baltimore, Md.)

Chocron ES,Sayre NL,Holstein D,Saelim N,Ibdah JA,Dong LQ,Zhu X,Cheng SY,Lechleiter JD

PA1-211A was used in western blot to study the role of mitochondrial trifunctional protein in thyroid hormone receptor-dependent stimulation of mitochondrial metabolism

Sun Jul 01 00:00:00 EDT 2012

Identical gene regulation patterns of T3 and selective thyroid hormone receptor modulator GC-1.

Endocrinology

Yuan C,Lin JZ,Sieglaff DH,Ayers SD,Denoto-Reynolds F,Baxter JD,Webb P

PA1-211A was used in western blot to investigate the pattern of GC-1 and T3-mediated gene expression in vivo and in vitro

Sun Jan 01 00:00:00 EST 2012

Cardiac PPARalpha Protein Expression is Constant as Alternate Nuclear Receptors and PGC-1 Coordinately Increase During the Postnatal Metabolic Transition.

PPAR research

Buroker NE,Ning XH,Portman M

PA1-211A was used in western blot to investigate the effect of postnatal metabolic transition on the expression of cardiac PPARalpha, alternate nuclear receptors and PGC-1

Thu Jul 14 00:00:00 EDT 2011

Thyroid hormone can favorably remodel the diabetic myocardium after acute myocardial infarction.

Molecular and cellular biochemistry

Kalofoutis C,Mourouzis I,Galanopoulos G,Dimopoulos A,Perimenis P,Spanou D,Cokkinos DV,Singh J,Pantos C

PA1-211A was used in western blot to investigate the effect of thyroid hormone on remodelling the diabetic myocardium

Wed Dec 01 00:00:00 EST 2010

Up-regulation of type 2 iodothyronine deiodinase in dilated cardiomyopathy.

Cardiovascular research

Wang YY,Morimoto S,Du CK,Lu QW,Zhan DY,Tsutsumi T,Ide T,Miwa Y,Takahashi-Yanaga F,Sasaguri T

PA1-211A was used in western blot to investigate the possible mechanism of the pathogenesis of DCM caused by hyperthyroidism using a konck-in mouse model

Wed Sep 01 00:00:00 EDT 2010

Thyroid hormone receptor alpha1 downregulation in postischemic heart failure progression: the potential role of tissue hypothyroidism.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

Pantos C,Mourouzis I,Galanopoulos G,Gavra M,Perimenis P,Spanou D,Cokkinos DV

PA1-211A was used in western blot to investigate the downregulation of thyroid hormone receptor alpha1 in postischemic heart failure progression

Wed Sep 01 00:00:00 EDT 2010

Aging impairs myocardial fatty acid and ketone oxidation and modifies cardiac functional and metabolic responses to insulin in mice.

American journal of physiology. Heart and circulatory physiology

Hyyti OM,Ledee D,Ning XH,Ge M,Portman MA

PA1-211A was used in western blot to investigate the effect of aging on myocardial fatty acid, ketone oxidation, and insulin sensitivity in mice

Wed Sep 01 00:00:00 EDT 2010

TNF-alpha administration in neonatal cardiomyocytes is associated with differential expression of thyroid hormone receptors: a response prevented by T3.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

Pantos C,Xinaris C,Mourouzis I,Kokkinos AD,Cokkinos DV

PA1-211A was used in western blot to investigate the effect of tumor necrosis factor alpha administration on thyroid hormone receptors in neonatal cardiomyocytes

Wed Oct 01 00:00:00 EDT 2008

Inhibition of apoptotic potency by ligand stimulated thyroid hormone receptors located in mitochondria.

Apoptosis : an international journal on programmed cell death

Saelim N,Holstein D,Chocron ES,Camacho P,Lechleiter JD

PA1-211A was used in western blot to investigate the role of thyroid hormone receptors in apoptosis

Mon Oct 01 00:00:00 EDT 2007

De-phosphorylation of TRalpha-1 by p44/42 MAPK inhibition enhances T(3)-mediated GLUT5 gene expression in the intestinal cell line Caco-2 cells.

Biochemical and biophysical research communications

Mochizuki K,Sakaguchi N,Takabe S,Goda T

PA1-211A was used in EMSA to investigate the effect of U0126 on thyroid receptor alpha-1 phosphorylation status and GLUT5 expression in Caco-2 cells

Fri Aug 10 00:00:00 EDT 2007

Thyroid hormone attenuates cardiac remodeling and improves hemodynamics early after acute myocardial infarction in rats.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

Pantos C,Mourouzis I,Markakis K,Dimopoulos A,Xinaris C,Kokkinos AD,Panagiotou M,Cokkinos DV

PA1-211A was used in western blot to investigate the role of thyroid hormone on cardiac remodeling and myocardial performance in rat

Wed Aug 01 00:00:00 EDT 2007

Time-dependent changes in the expression of thyroid hormone receptor alpha 1 in the myocardium after acute myocardial infarction: possible implications in cardiac remodelling.

European journal of endocrinology

Pantos C,Mourouzis I,Xinaris C,Kokkinos AD,Markakis K,Dimopoulos A,Panagiotou M,Saranteas T,Kostopanagiotou G,Cokkinos DV

PA1-211A was used in western blot to investigate the expression of thyroid hormone receptor alpha 1 in the myocardium after acute myocardial infarction

Sun Apr 01 00:00:00 EDT 2007

The dominant negative thyroid hormone receptor beta-mutant {Delta}337T alters PPAR{alpha} signaling in heart.

American journal of physiology. Endocrinology and metabolism

Buroker NE,Young ME,Wei C,Serikawa K,Ge M,Ning XH,Portman MA

PA1-211A was used in western blot to investigate the effect of thyroid hormone receptor beta-mutant for PPAR alpha signaling in heart

Thu Feb 01 00:00:00 EST 2007

Thyroid hormone receptor isoforms localize to cardiac mitochondrial matrix with potential for binding to receptor elements on mtDNA.

Mitochondrion

Morrish F,Buroker NE,Ge M,Ning XH,Lopez-Guisa J,Hockenbery D,Portman MA

PA1-211A was used in western blot to study teh localization of thyroid hormone receptor isoforms in cardiac mitochondrial matrix

Thu Jun 01 00:00:00 EDT 2006

Thyroid hormone-mediated negative transcriptional regulation of Necdin expression.

Journal of molecular endocrinology

Nygård M,Becker N,Demeneix B,Pettersson K,Bondesson M

PA1-211A was used in western blot to investigate the effect of thyroid hormone on Necdin expression

Thu Jun 01 00:00:00 EDT 2006

Nuclear localization of protein kinase C-alpha induces thyroid hormone receptor-alpha1 expression in the cardiomyocyte.

American journal of physiology. Heart and circulatory physiology

Kenessey A,Sullivan EA,Ojamaa K

PA1-211A was used in western blot to study the role of protein kinase C signaling in regulating the function of thyroid hormone receptor in the cardiomyocyte

Sun Jan 01 00:00:00 EST 2006

Thyroid hormone receptors alpha1 and beta1 are downregulated in the post-infarcted rat heart: consequences on the response to ischaemia-reperfusion.

Basic research in cardiology

Pantos C,Mourouzis I,Saranteas T,Paizis I,Xinaris C,Malliopoulou V,Cokkinos DV

PA1-211A was used in western blot to investigate the function of thyroid hormone signaling in the response of heart to ischaemia-reperfusion after myocardial infarction

Thu Sep 01 00:00:00 EDT 2005

Ligand-mediated decrease of thyroid hormone receptor-alpha1 in cardiomyocytes by proteosome-dependent degradation and altered mRNA stability.

American journal of physiology. Heart and circulatory physiology

Kenessey A,Ojamaa K

PA1-211A was used in western blot to study how T3 regulates the degradation of TR

Tue Feb 01 00:00:00 EST 2005

Multiple messenger ribonucleic acid variants regulate cell-specific expression of human thyroid hormone receptor beta1.

Molecular endocrinology (Baltimore, Md.)

Frankton S,Harvey CB,Gleason LM,Fadel A,Williams GR

PA1-211A was used in immunocytochemistry to demonstrate the function of human thyroid hormone receptor beta1 5-UTR mRNAs.

Thu Jul 01 00:00:00 EDT 2004

Thyroid-hormone-dependent negative regulation of thyrotropin beta gene by thyroid hormone receptors: study with a new experimental system using CV1 cells.

The Biochemical journal

Nakano K,Matsushita A,Sasaki S,Misawa H,Nishiyama K,Kashiwabara Y,Nakamura H

PA1-211A was used in western blot to investigate the role of thyroid hormone receptors in regulation of thyrotropin beta gene

Mon Mar 01 00:00:00 EST 2004

TR expression and function in human bone marrow stromal and osteoblast-like cells.

The Journal of clinical endocrinology and metabolism

Siddiqi A,Parsons MP,Lewis JL,Monson JP,Williams GR,Burrin JM

PA1-211A was used in immunocytochemistry to investigate the functions of TR in human bone marrow stromal and osteoblast-like cells.

Fri Feb 01 00:00:00 EST 2002

Thyroid status affects number and localization of thyroid hormone receptor expressing mast cells in bone marrow.

Bone

Siebler T,Robson H,Bromley M,Stevens DA,Shalet SM,Williams GR

PA1-211A was used in immunohistochemistry to investigate the association between thyroid status and thyroid hormone receptor expressing mast cells

Tue Jan 01 00:00:00 EST 2002

Nucleocytoplasmic shuttling of the thyroid hormone receptor alpha.

Molecular endocrinology (Baltimore, Md.)

Bunn CF,Neidig JA,Freidinger KE,Stankiewicz TA,Weaver BS,McGrew J,Allison LA

PA1-211A was used in immunocytochemistry to study the nucleocytoplasmic translocation of the thyroid hormone receptor alpha.

Sun Apr 01 00:00:00 EST 2001

Expression of thyroid receptor isoforms in the human fetal central nervous system and the effects of intrauterine growth restriction.

Clinical endocrinology

Kilby MD,Gittoes N,McCabe C,Verhaeg J,Franklyn JA

PA1-211A was used in immunocytochemistry to investigate the effects of severe IUGR on the expression of TR isoforms in the human fetal central nervous system

Sun Oct 01 00:00:00 EDT 2000

Thyroid hormone inhibits the human prolactin gene promoter by interfering with activating protein-1 and estrogen stimulations.

Molecular endocrinology (Baltimore, Md.)

Pernasetti F,Caccavelli L,Van de Weerdt C,Martial JA,Muller M

PA1-211A was used in EMSA assay to investigate the role of thyroid hormone on hPRL gene transcription

Sun Jun 01 00:00:00 EDT 1997

Bioinformatics

Protein Aliases: avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1; c-erb-A protein; c-erb-A thyroid hormone receptor; c-erbA-1; C-erbA-alpha; c-erbA-alpha2; c-erbAalpha; c-erbAalpha2; cerbA protein; cerbAalpha; E ERB-T-1; EAR-7; ERBA ALPHA; ERBA related 7; ERBA-related 7; MGC000261; MGC43240; Nuclear receptor subfamily 1 group A member 1; Oncogene ERBA; Thyroid hormone receptor alpha; thyroid hormone receptor alpha 1; thyroid hormone receptor alpha 1 (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1 formerly ERBA1); thyroid hormone receptor beta; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); thyroid normone nuclear receptor alpha variant 1; TR alpha 1; TR alpha 1+2; TR alpha 2; triiodothyronine receptor; unnamed protein product; V-erbA-related protein 7

Gene Aliases: 6430529J03Rik; AR7; AW259572; c-ERBA-1; C-erba-alpha; CHNG6; EAR7; ERB-T-1; ERBA; ERBA1; NR1A1; Rvr; T3R[a]; T3Ralpha; THRA; THRA1; THRA2

UniProt ID: (Chicken) P04625, (Human) P10827, (Mouse) P63058, (Rat) P63059

Entrez Gene ID: (Chicken) 396251, (Human) 7067, (Mouse) 21833, (Rat) 81812

Molecular Function: C4 zinc finger nuclear receptor DNA-binding transcription factor zinc finger transcription factor gene-specific transcriptional regulator