PA1-216 detects the thyroid hormone receptor alpha 2 from human and mouse samples.
PA1-216 has been successfully used in Western blot, ICC/IF and immunohistochemistry (paraffin) procedures. By Western blot, this antibody detects bands at ~58 kDa representing Tra2 in mouse tissue. This antibody also detects a ~43 kDa protein which is believed to be non-specific.
The PA1-216 immunizing peptide corresponds to amino acid residues 455-469 from rat thyroid hormone receptor alpha 2.
Thyroid hormone receptor alpha 2 protein mediates the function of thyroid hormone. There are three forms of the thyroid hormone receptors known as alpha-1, alpha-2 and beta. Studies have suggested that these three forms of the thyroid hormone receptor are abundant in most tissues; however, none of these three thyroid hormone receptors were abundant in the liver, which is the major thyroid hormone-responsive organ. Therefore another type of thyroid hormone receptor is believed to be present in liver.
The identification of the several types of thyroid hormone receptor may explain the normal variation in thyroid hormone responsiveness of various organs and the selective tissue abnormalities found in the thyroid hormone resistance syndromes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: c-erbA-1; c-erbA-alpha; c-erbAalpha; EAR-7; ERBA-related 7; Nuclear receptor subfamily 1 group A member 1; Thyroid hormone receptor alpha; thyroid hormone receptor alpha 1; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); thyroid normone nuclear receptor alpha variant 1; TR alpha 1; TR Alpha 2; triiodothyronine receptor; V-erbA-related protein 7
Gene Aliases: 6430529J03Rik; AR7; AW259572; c-ERBA-1; C-erba-alpha; CHNG6; EAR7; ERB-T-1; ERBA; ERBA1; NR1A1; Rvr; T3R[a]; T3Ralpha; THRA; THRA1; THRA2