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Invitrogen
THRA Polyclonal Antibody
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Product Details
PA5-33076
Product Specifications
Species Reactivity
Human,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 16 amino acid peptide from ligand-binding domain of human THRA.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Horse (94%); Hamster (88%); Rat (81%).
For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-erbA protooncogene; c-erbA-1; c-erbA-alpha; cerbA protein; cerbAalpha; E ERB-T-1; EAR-7; ERBA ALPHA; ERBA related 7; ERBA-related 7; MGC000261; MGC43240; Nuclear receptor subfamily 1 group A member 1; Oncogene ERBA; THRA; Thyroid hormone receptor alpha; thyroid hormone receptor alpha 1; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); TR; TR alpha 1+2; triiodothyronine receptor; unnamed protein product; V-erbA-related protein 7
Gene Aliases: AR7; c-erbA; c-ERBA-1; CHNG6; EAR7; ERB-T-1; ERBA; ERBA1; NR1A1; THRA; THRA1; THRA2; THRalpha; THRalpha1; THRalpha2; TRalpha; TRalpha1; TRalpha2
UniProt ID: (Human) P10827
Entrez Gene ID: (Human) 7067
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
TBP-class protein binding
protein domain specific binding
chromatin DNA binding
sequence-specific DNA binding
macromolecular complex binding
metal ion binding
thyroid hormone binding
general transcription initiation factor binding
negative regulation of transcription from RNA polymerase II promoter
cartilage condensation
ossification
thyroid hormone mediated signaling pathway
regulation of thyroid hormone mediated signaling pathway
positive regulation of thyroid hormone receptor signaling pathway
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
learning or memory
regulation of heart contraction
female courtship behavior
response to cold
hormone-mediated signaling pathway
organ morphogenesis
negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
cell differentiation
erythrocyte differentiation
thyroid gland development
regulation of myeloid cell apoptotic process
mRNA transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-templated
positive regulation of female receptivity
positive regulation of transcription from RNA polymerase II promoter
retinoic acid receptor signaling pathway
regulation of lipid catabolic process
Type I pneumocyte differentiation
positive regulation of cold-induced thermogenesis
negative regulation of DNA-templated transcription, initiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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