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THRA1 Polyclonal Antibody

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THRA1 Polyclonal Antibody

Product Details

BS-6221R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

Flow Cytometry (Flow)

1:20-1:100
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human THR, amino acids 81-180.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1; c-erb-A thyroid hormone receptor; c-erbA protooncogene; c-erbA-1; C-erbA-alpha; c-erbA-alpha2; c-erbAalpha; c-erbAalpha2; cerbA protein; cerbAalpha; E ERB-T-1; EAR-7; ERBA ALPHA; ERBA related 7; ERBA-related 7; MGC000261; MGC43240; Nuclear receptor subfamily 1 group A member 1; Oncogene ERBA; THRA; Thyroid hormone receptor alpha; thyroid hormone receptor alpha 1; thyroid hormone receptor alpha 1 (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1 formerly ERBA1); thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); TR; TR alpha 1; TR alpha 1+2; TR alpha 2; triiodothyronine receptor; unnamed protein product; V-erbA-related protein 7

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Gene Aliases: 6430529J03Rik; AR7; AW259572; c-erbA; c-ERBA-1; C-erba-alpha; CHNG6; EAR7; ERB-T-1; ERBA; ERBA1; NR1A1; Rvr; T3R[a]; T3Ralpha; THRA; THRA1; THRA2; THRalpha; THRalpha1; THRalpha2; TRalpha; TRalpha1; TRalpha2

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UniProt ID: (Human) P10827, (Mouse) P63058, (Rat) P63059

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Entrez Gene ID: (Human) 7067, (Mouse) 21833, (Rat) 81812

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding zinc ion binding TBP-class protein binding protein domain specific binding chromatin DNA binding sequence-specific DNA binding macromolecular complex binding metal ion binding thyroid hormone binding general transcription initiation factor binding steroid receptor RNA activator RNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding steroid hormone receptor activity single-stranded RNA binding thyroid hormone receptor activity transcription factor binding protein complex binding protein homodimerization activity transcription regulatory region DNA binding intronic transcription regulatory region DNA binding protein heterodimerization activity protein dimerization activity C4 zinc finger nuclear receptor DNA-binding transcription factor zinc finger transcription factor gene-specific transcriptional regulator
Process(es)
negative regulation of transcription from RNA polymerase II promoter cartilage condensation ossification thyroid hormone mediated signaling pathway regulation of thyroid hormone mediated signaling pathway positive regulation of thyroid hormone receptor signaling pathway regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter learning or memory regulation of heart contraction female courtship behavior response to cold hormone-mediated signaling pathway organ morphogenesis negative regulation of RNA polymerase II transcriptional preinitiation complex assembly cell differentiation erythrocyte differentiation thyroid gland development regulation of myeloid cell apoptotic process mRNA transcription from RNA polymerase II promoter negative regulation of transcription, DNA-templated positive regulation of female receptivity positive regulation of transcription from RNA polymerase II promoter retinoic acid receptor signaling pathway regulation of lipid catabolic process Type I pneumocyte differentiation positive regulation of cold-induced thermogenesis negative regulation of DNA-templated transcription, initiation transcription, DNA-templated positive regulation of myotube differentiation intracellular receptor signaling pathway cytoplasmic sequestering of transcription factor steroid hormone mediated signaling pathway negative regulation of sequence-specific DNA binding transcription factor activity kidney development liver development brain development lung development adrenal gland development response to nutrient levels response to drug digestive tract development embryonic organ development
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