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Proteintech
TIA1 Polyclonal Antibody
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Product Details
12133-2-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TIA1 Fusion Protein Ag2778 (1-214 aa encoded by BC015944)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Amount
34.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MEDEMPKTL YVGNLSRDVT EALILQLFSQ IGPCKNCKMI MDTAGNDPYC FVEFHEHRHA AAALAAMNGR KIMGKEVKVN WATTPSSQKK DTSSSTVVST QRSQDHFHVF VGDLSPEITT EDIKAAFAPF GRISDARVVK DMATGKSKGY GFVSFFNKWD AENAIQQMGG QWLGGRQIRT NWATRKPPAP KSTYECRCIG EEKEMWNFGE KYARF (1-214 aa encoded by BC015944)
Target Information
Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cytotoxic granule associated RNA binding protein TIA1; cytotoxic granule-associated RNA binding protein 1; cytotoxic granule-associated RNA-binding protein 1; Nucleolysin TIA-1; Nucleolysin TIA-1 isoform p40; p40 TIA 1; p40-TIA-1; p40-TIA-1 (containing p15-TIA-1); RNA-binding protein TIA-1; T-cell-restricted intracellular antigen-1; TIA 1; TIA-1; TIA1 protein; TIAL1; TIAR; unnamed protein product
Gene Aliases: 2310050N03Rik; AI256674; ALS26; mTIA-1; Tia; TIA-1; TIA1; WDM
UniProt ID: (Human) P31483, (Mouse) P52912
Entrez Gene ID: (Human) 7072, (Rat) 312510, (Mouse) 21841
negative regulation of translation
negative regulation of cytokine biosynthetic process
regulation of mRNA splicing, via spliceosome
regulation of alternative mRNA splicing, via spliceosome
negative regulation of cytokine production
mRNA processing
apoptotic process
RNA splicing
stress granule assembly
protein localization to cytoplasmic stress granule
positive regulation of epithelial cell apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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