A suggested positive control is human kidney tissue lysate.
PA5-20060 can be used with blocking peptide PEP-0179.
TIRP is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TIRP, along with other molecules such as TRIF, MAL, and MyD88, serves as an adaptor protein that allows for the interaction and activation of the IL-1R-associated kinase (IRAK) family, the subsequent activation of TNF receptor associated factor (TRAF)-6, and ultimately the activation of NF-kappa-B. Expression of TIRP appears to be essential for TLR4 signalling.
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Protein Aliases: cytoplasmic adaptor; MyD88-4; NF-kappa-B-activating protein 502; Putative NF-kappa-B-activating protein 502; TAG; TICAM-2; TIR domain-containing adapter molecule 2; TIR domain-containing adapter protein; TMED7-TICAM2 read-through transcript; Toll-interleukin I receptor domain (TIR)-containing adaptor molecule (TICAM) 2; toll-like receptor adaptor molecule 2; Toll-like receptor adaptor protein 3; toll/interleukin-1 receptor (TIR) domain-containing adapter protein; Toll/interleukin-1 receptor domain-containing protein; TRAM adaptor with GOLD domain; TRIF-related adapter molecule; TRIF-related adapter molecule TRAM; TRIF-related adaptor molecule
Gene Aliases: B430113A10; MyD88-4; TICAM-2; TICAM2; TIRAP3; TIRP; TRAM; Trif